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of neonatal neurons. Further, the expression of the chloride transporter, KCC2, is less in immature neurons, as a result of which there is the above-mentioned high intracellular chloride. On receiving a GABAergic stimulus, there is an efflux of
Chloride from the cell, resulting in depolarization of
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the cell. This causes the GDPs. Once the KCC2 expression is relatively high, as in the adult, mature neurons, the GDPs almost simultaneously disappear. The increased level of KCC2 expression in adult, mature neurons alone is not the reason for the disappearance of the GDPs, however.
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at early stages of development. These patterns of activity differ a lot from both the adult brain activity, and
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One of the main conditions for GDP development (that is met in premature but not adult brain) is that
35:) is a type of patterned spontaneous activity that can be observed in preparations of developing
109:"GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations"
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GDPs were postulated to be essential for the establishment and maturation of
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Ben-Ari Y, Gaiarsa JL, Tyzio R, Khazipov R (October 2007).
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81:. This is caused by a much higher concentration of
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66:connections in the immature brain .
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73:action on these stages should be
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18:Giant depolarizing potentials
55:they last for approximately
29:giant depolarizing potential
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153:Developmental neuroscience
125:10.1152/physrev.00017.2006
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119:(4): 1215–84.
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