2260:
26:
551:, which are capable of developing into virtually any cell type in the human body. His discovery of induced pluripotent stem cells, or iPS cells, has since revolutionized the fields of developmental biology, stem cell research and both personalized and regenerative medicine. In 2012 Yamanaka was awarded the Nobel Prize in Physiology or Medicine.
398:, behavioral testing and automated high-throughput analyses. In addition, Gladstone investigators seek to accelerate the movement of basic science discoveries into clinical trials with efforts to bridge the so-called "Valley of Death". The research features an emphasis on the common threads linking the various diseases and treatments for them.
513:
prevents a type of brain cells from becoming "hyperactive". If not enough progranulin is available the hyperactivity can become toxic and result in extensive inflammation that kills brain cells and can lead to the development of FTD. Also showed that too much of another protein called TDP-43 plays a
2124:
Chengzhong Wang, Ramsey Najm, Qin Xu, Dah-eun Jeong, David Walker, Maureen E. Balestra, Seo Yeon Yoon, Heidi Yuan, Gang Li, Zachary A. Miller, Bruce L. Miller, Mary J. Malloy & Yadong Huang. Gain of toxic
Apolipoprotein E4 effects in Human iPSC-Derived Neurons Is Ameliorated by a Small-Molecule
230:
helped launch the Center for
Comprehensive Alzheimer's Disease Research, while the Roddenberry Foundation helped launch the Roddenberry Stem Cell Center for Biology and Medicine. Also in 2011, the independent and philanthropic Gladstone Foundation formed with the mission of expanding the financial
1007:
Perez-Bermejo, Juan A.; Kang, Serah; Rockwood, Sarah J.; Simoneau, Camille R.; Joy, David A.; Silva, Ana C.; Ramadoss, Gokul N.; Flanigan, Will R.; Fozouni, Parinaz; Li, Huihui; Chen, Pei-Yi; Nakamura, Ken; Whitman, Jeffrey D.; Hanson, Paul J.; McManus, Bruce M.; Ott, Melanie; Conklin, Bruce R.;
273:
Gladstone cardiovascular scientists research the spectrum of cardiovascular disease, utilizing developmental, chemical, and stem cell biology approaches, as well as genomics techniques, across a variety of research programs and institutes. Their research has included:
464:), and Alzheimer's disease (neurofibrillary tangles and amyloid-beta plaques)—discovering that rather than being the culprit of neuronal death, these aggregates are part of a defense mechanism that safely sequesters toxin proteins in the brain.
209:. Under inaugural president Robert Mahley—a cardiovascular scientist recruited from the National Institutes of Health—the institutes was launched with a $ 8 million trust from the late commercial real estate developer, J. David Gladstone.
259:
Gladstone is also home to eight centers for researchers from different institutes to collaborate. These centers focus on stem and iPS cell research, as well as neurodegenerative disease research and therapeutics.
554:
Since
Yamanaka's discovery, scientists at Gladstone have used iPS technology to research solutions for Huntington's disease and Alzheimer's disease, as well as create a new model for testing HIV/AIVD vaccines.
500:
Studying abnormal inflammatory responses by immune cells in the central nervous system—which may contribute to the progression of multiple sclerosis, neurodegenerative disorders and many other neurological
487:
can help prevent the destruction of brain cells, and how the p75 neurotrophin receptor —a protein involved in the development of brain cells— plays unexpected roles in both
Alzheimer's and Type 2 diabetes.
425:. Uncovered the molecular pathways that link apoE and Alzheimer's disease, and identifying new drugs that counteract detrimental effects of apoE4—the most important genetic risk factor for Alzheimer's.
344:
In 2020, two new institutes were formed; the
Gladstone Institute of Virology, and the Gladstone-UCSF Institute of Genomic Immunology, to study how viruses interact with human cells to cause disease.
1298:
Doitsh, Gilad; Galloway, Nicole L. K.; Geng, Xin; Yang, Zhiyuan; Monroe, Kathryn M.; Zepeda, Orlando; Hunt, Peter W.; Hatano, Hiroyu; Sowinski, Stefanie; Muñoz-Arias, Isa; Greene, Warner C. (2014).
594:(also known as "jumping genes", because they move around within the chromosomes of a single cell) residing in our DNA become more active when a skin cell is reprogrammed into an iPS cell.
1702:
Armakola, M.; Higgins, M. J.; Figley, M. D.; Barmada, S. J.; Scarborough, E. A.; Diaz, Z.; Fang, X.; Shorter, J.; Krogan, N. J.; Finkbeiner, S.; Farese Jr, R. V.; Gitler, A. D. (2012).
514:
role in FTD disease progression. Importantly, Gladstone scientists have identified a means to suppress the toxic effects of TDP-43 for FTD and for another neurodegenerative disease:
163:
is an independent, non-profit biomedical research organization whose focus is to better understand, prevent, treat and cure cardiovascular, viral and neurological conditions such as
2183:
1832:
1962:
2400:
194:(UCSF), and located adjacent to UCSF's Mission Bay campus. The organization comprises five major institutes, as well as multiple centers focused on various areas of research.
982:
434:. Understanding how lowering brain levels of the tau protein improves memory and other cognitive functions in mice genetically engineered to mimic Alzheimer's disease.
2504:
2453:
480:. Studying mitochondria, the energy-producing subunits of cells, and their role in multiple neurodegenerative conditions, including Alzheimer's, Parkinson's and ALS.
1862:
2176:
219:
Dr. Mahley stepped down as president in 2010 to return to active research, and was replaced by R. Sanders
Williams (former Dean of the School of Medicine at
227:
2364:
1521:
1948:
1160:
1987:
1814:
2499:
1134:
1200:
Doitsh, Gilad; Cavrois, Marielle; Lassen, Kara G.; Zepeda, Orlando; Yang, Zhiyuan; Santiago, Mario L.; Hebbeler, Andrew M.; Greene, Warner C. (2010).
2325:
2315:
351:, including its long-term effects on the heart, and studying samples of SARS-CoV-2 variations appearing in California, and their resistances to the
2509:
2169:
1633:
942:
845:
108:
411:. Studying how damage to neurons affects their ability to communicate through chemical and electrical signals, which manifests as sub-clinical
1084:
723:
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898:
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281:
Studying various methods to repair damaged hearts, including creating heart cells from skin samples and converting scar tissue into muscle.
1551:
749:
2310:
1058:
2354:
467:
Investigating the network of brain cells that controls movement, and how its dysfunction leads to the symptoms of
Parkinson's disease.
872:
2494:
2192:
191:
1619:
778:
690:
607:; repurposing already-approved drugs for new uses and clinical trials, to speed up (and lower the cost of) drug development.
2369:
1010:"SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19"
2349:
2320:
1576:
2416:
1676:
1251:"Cell-to-Cell Transmission of HIV-1 Is Required to Trigger Pyroptotic Death of Lymphoid-Tissue-Derived CD4 T Cells"
1186:
2432:
1110:"Drug Approval Package: Truvada (emtricitabine 200 mg/tenofovir disoproxil fumarate 300 mg) NDA #021752Orig1s030"
1109:
1161:"Gladstone scientists discover how immune cells die during HIV infection; identify potential drug to block AIDS"
2427:
1412:
206:
415:-like seizures. Discovered a link between this process and many of the deficits linked to Alzheimer's disease.
1988:"Scientists Discover How Key Immune Cells Die During HIV Infection and Identify Potential Drug to Block AIDS"
528:
387:
284:
Exploring human evolution and metabolism to understand the human genome, and illnesses at the cellular level.
180:
1620:"Robotic microscope: a tinker's breakthrough / Neural disease researcher melds optics and computer software"
983:"Gladstone Institutes researchers use genetic clues to identify possible drug for treating heart conditions"
2395:
803:
562:
Reprogramming cardiac connective tissue located in the heart directly into beating cardiac muscle cells.
2359:
2284:
1833:"Gladstone Institute Release: Study Reveals A New Method To Address A Major Barrier To Eradicating HIV"
213:
924:
849:
495:
1949:"Reprogamming Cells Could Eliminate Dangers of Side Effects in Medicine, US News & World Report"
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635:
536:
49:
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1890:
580:
505:
449:
383:
379:
1202:"Abortive HIV Infection Mediates CD4 T Cell Depletion and Inflammation in Human Lymphoid Tissue"
2385:
2259:
2249:
2239:
1059:"SF's Gladstone Institutes splits research work in battle against coronavirus, future diseases"
584:
457:
406:
375:
371:
172:
1704:"Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models"
1522:"Pfizer, Moderna COVID-19 vaccines induce responses against 2 key variants, small study finds"
442:. Studying TDP-43, another protein that may contribute to diverse neurodegenerative disorders.
1357:"IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV"
176:
2111:
1767:
1368:
1311:
1249:
Galloway, NL; Doitsh, G; Monroe, KM; Yang, Z; Muñoz-Arias, I; Levy, DN; Greene, WC (2015).
565:
Discovering new ways to use chemical compounds to convert cells from one type into another.
548:
8:
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154:
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1315:
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2088:
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2006:
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1332:
1299:
1275:
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1226:
1201:
1034:
1009:
604:
391:
205:
Gladstone
Institutes was founded in 1979 as a research and training facility housed at
1595:"Gladstone scientists identify role of key protein in ALS and frontotemporal dementia"
873:"Boost for biotech in S.F. / Gladstone Institutes to open Mission Bay research center"
603:
The
Gladstone Center for Translational Advancement was formed in 2017, and focuses on
336:
Studying how HIV integrates and replicates within the body, and how it kills lymphoid
278:
Determining the genetic factors of congenital birth defects in early heart development
2093:
2075:
2036:
1927:
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1733:
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671:
395:
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2067:
2026:
2018:
1917:
1785:
1775:
1723:
1715:
1493:
1477:
1466:"Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant"
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1327:
1319:
1270:
1262:
1221:
1213:
1029:
1021:
591:
453:
420:
359:
330:
Participating as a member of the Martin
Delaney Collaboratory to study HIV latency.
1552:"Gladstone researchers find epilepsy drug that may work for Alzheimer's patients"
1266:
1025:
686:
680:
631:
532:
220:
184:
1863:"Reversing a heart attack: scientists reprogram scar tissue into working muscle"
2022:
1922:
1905:
1904:
Higashi, Hiroyuki; Brüstle, Oliver; Daley, George Q.; Yamanaka, Shinya (2011).
1481:
1217:
659:
Alex Marson, MD, PhD — Director, Gladstone-UCSF Institute of Genomic Immunology
348:
316:. In 2011, Gladstone launched a $ 25 million initiative around HIV and aging.
304:
in response to the HIV/AIDS crisis. Since then the institute has also studied
223:). Deepak Srivastava became the institute's third president in January 2018.
2488:
2207:
2079:
2071:
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622:
Benoit Bruneau, PhD — Director, Gladstone Institute of Cardiovascular Disease
337:
164:
123:
110:
95:
83:
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212:
In 2004 the Gladstone Institutes moved to a new facility in San Francisco's
187:, to improve drug discovery, personalized medicine and tissue regeneration.
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study, which led to the FDA approval of Truvada for HIV prevention in 2012.
1634:"Latest News, Diets, Workouts, Healthy Recipes - MSN Health & Fitness"
25:
2458:
2448:
2279:
2125:
Structure Corrector. Nature Medicine, 2018 DOI: 10.1038/s41591-018-0004-z
2112:"Researchers Fix Genetic Risk Factor of Alzheimer's in Human Brain Cells"
1300:"Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection"
665:
662:
Lennart Mucke, MD — Director, Gladstone Institute of Neurological Disease
544:
540:
461:
448:. Helping to uncover the mystery behind protein aggregations—observed in
430:
305:
1323:
956:
644:
Steve Finkbeiner, MD, PhD— Director, Center for Systems and Therapeutics
370:
Research at Gladstone focuses on major neurological diseases including:
2213:
1963:"Future Alzheimer's Therapy: Scientists fix ApoE4 in human brain cells"
674:, PhD — Director, Gladstone Institute of Data Science and Biotechnology
309:
301:
89:
656:
Robert W. Mahley, MD, PhD — President emeritus and Senior Investigator
558:
Other work at the Data Science & Biotechnology Institute include:
347:
The Institute of Virology has been involved in research regarding the
175:. Its researchers study these diseases using techniques of basic and
1594:
576:
484:
412:
1719:
2054:
Yap, Jeremy K. Y.; Moriyama, Miyu; Iwasaki, Akiko (July 15, 2020).
1906:"The Nomenclature System Should be Sustainable, but Also Practical"
750:"Gladstone, Jesse Dylan collaborate as research institute rebrands"
531:
technology by one of its senior investigators, 2012 Nobel Laureate
510:
313:
297:
168:
2191:
2156:
2056:"Inflammasomes and Pyroptosis as Therapeutic Targets for COVID-19"
1655:"NIH-funded Researchers Show Possible Trigger for MS Nerve Damage"
1135:"Federal funds may help Gladstone to solve problem of HIV latency"
333:
Studying the "accelerated aging" effects associated with HIV/AIDS.
144:
1463:
1439:
1006:
569:
535:. In 2006, Yamanaka discovered the technology, by which ordinary
475:
352:
2305:
647:
Warner Greene, MD, PhD — Director, Center for HIV Cure Research
356:
190:
Founded in 1979, Gladstone is academically affiliated with the
179:. Another focus at Gladstone is building on the development of
2401:
University of California, San Francisco Fetal Treatment Center
1440:"Bay Area researchers probe how coronavirus attacks the heart"
1355:
Monroe, KM; Yang, Z; Johnson, JR; et al. (January 2014).
446:
Protein aggregates and their role in neurodegenerative disease
527:
Another focus at Gladstone is building on the development of
438:
324:
197:
The current president of the institute is Deepak Srivastava.
1815:"Gurdon and Yamanaka Win Nobel Prize for Stem Cell Research"
1701:
183:
technology by one of its investigators, 2012 Nobel Laureate
1903:
2007:"Dissecting How CD4 T Cells Are Lost During HIV Infection"
1669:
1199:
515:
1248:
1614:
1612:
677:
Deepak Srivastava, MD — President, Gladstone Institutes
1885:
1883:
1297:
1806:
715:
668:, MD, PhD — Director, Gladstone Institute of Virology
2365:
UCSF Helen Diller Family Comprehensive Cancer Center
1609:
1187:"FDA panel backs drug to prevent HIV infection risk"
772:
770:
1880:
1649:
1647:
1577:"Studies tie abnormal protein build-up to dementia"
2128:
2053:
689:— MD, PhD — Senior Investigator. Awarded the 2012
239:Gladstone Institutes consists of five institutes:
2505:Research institutes in the San Francisco Bay Area
2326:Center for Tobacco Control Research and Education
2316:California Institute for Quantitative Biosciences
1626:
1354:
767:
579:to create human models to research solutions for
296:In 1991, Gladstone expanded its focus to include
2486:
2136:"The Nobel Prize in Physiology or Medicine 2012"
1644:
1587:
1413:"Gladstone-UCSF Institute of Genomic Immunology"
1943:
1941:
1856:
1854:
1760:Proceedings of the National Academy of Sciences
1545:
1543:
2194:University of California, San Francisco (UCSF)
1749:
1747:
899:"Williams spins science into fundraising gold"
634:, PhD — Senior Investigator. Awarded the 2020
619:Katerina Akassoglou, PhD — Senior Investigator
615:Current researchers at the institute include:
287:Studying the effects of COVID-19 on the heart.
2177:
1464:Deng, Xianding; et al. (June 24, 2021).
981:Ashley, Dan; Didion, Tim (January 29, 2021).
838:
829:
827:
825:
641:Barbara Engelhardt, PhD — Senior Investigator
394:. This research incorporates animal models,
252:Institute of Data Science & Biotechnology
2004:
1938:
1851:
1540:
1437:
1085:"Gladstone boosts funding, science and fame"
980:
804:"Profile: The J. David Gladstone institutes"
779:"Gladstone to announce new stem cell center"
724:"Gladstone boosts funding, science and fame"
2311:Bixby Center for Global Reproductive Health
1744:
1677:"Researchers Lasso TDP-43 With RNA Lariats"
1438:Ashley, Dan; Didion, Tim (March 27, 2021).
941:: CS1 maint: numeric names: authors list (
234:
2184:
2170:
1891:"Skin cells reprogrammed into brain cells"
848:. The Gladstone Institutes. Archived from
822:
701:Anatol Kreitzer, PhD — Senior Investigator
650:Yadong Huang MD, PhD — Senior Investigator
543:from skin) could be "reprogrammed" into a
291:
24:
2500:Medical research institutes in California
2087:
2030:
1921:
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1727:
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1388:
1331:
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1179:
1033:
890:
598:
268:
2391:UC Berkeley – UCSF Joint Medical Program
1980:
1050:
834:http://www.pnas.org/content/103/15/5641/
704:Todd McDevitt, PhD — Senior Investigator
2510:University of California, San Francisco
2355:UCSF Betty Irene Moore Women's Hospital
1569:
1056:
925:"New President at Gladstone Institutes"
653:Nevan Krogan, PhD — Senior Investigator
625:Bruce Conklin, MD — Senior Investigator
522:
365:
192:University of California, San Francisco
2487:
1860:
922:
776:
2330:Osher Center for Integrative Medicine
2165:
1967:Neuroscience from Technology Networks
1549:
896:
747:
721:
691:Nobel Prize in Physiology or Medicine
628:Sheng Ding, PhD — Senior Investigator
2370:Langley Porter Psychiatric Institute
1812:
1753:
1008:McDevitt, Todd C. (April 21, 2021).
870:
263:
2321:Center for Cerebrovascular Research
1861:Wilcox, Christie (April 18, 2012).
1189:. CBS Evening News. August 8, 2013.
568:Direct reprogramming of cells into
401:Current research programs include:
390:(ALS, or Lou Gehrig's disease) and
243:Institute of Cardiovascular Disease
13:
1813:Wade, Nicholas (October 8, 2012).
1167:(Press release). December 18, 2013
14:
2521:
2417:Community Regional Medical Center
2150:
1597:(Press release). January 12, 2010
1082:
777:Allday, Erin (October 19, 2011).
249:Institute of Neurological Disease
79:1650 Owens St., San Francisco, CA
2350:UCSF Benioff Children's Hospital
2258:
1754:Nair, Prashant (June 12, 2012).
957:"Science | Gladstone Institutes"
871:Levy, Dan (September 10, 2004).
340:, the fundamental cause of AIDS.
2495:Independent research institutes
2433:San Francisco VA Medical Center
2118:
2104:
2047:
2005:Doitsh, G.; Greene, WC (2016).
1998:
1955:
1951:. U.S. News & World Report.
1897:
1825:
1695:
1514:
1457:
1431:
1405:
1348:
1291:
1242:
1193:
1153:
1127:
1102:
1076:
1057:Fimrite, Peter (May 13, 2020).
1000:
974:
949:
547:state—i.e., a state similar to
255:Institute of Genomic Immunology
2428:San Francisco General Hospital
1014:Science Translational Medicine
916:
864:
796:
741:
610:
231:resources for the institutes.
207:San Francisco General Hospital
1:
1550:Leuty, Ron (August 6, 2012).
897:Leuty, Ron (April 29, 2011).
708:
529:induced pluripotent stem cell
388:amyotrophic lateral sclerosis
319:Their research has included:
181:induced pluripotent stem cell
2396:UCSF Alliance Health Project
1756:"Profile of Shinya Yamanaka"
1565:– via bizjournals.com.
1556:San Francisco Business Times
1267:10.1016/j.celrep.2015.08.011
1089:San Francisco Business Times
1026:10.1126/scitranslmed.abf7872
808:San Francisco Business Times
763:– via bizjournals.com.
754:San Francisco Business Times
748:Leuty, Ron (July 24, 2012).
722:Leuty, Ron (July 27, 2012).
228:S.D. Bechtel, Jr. Foundation
7:
683:, PhD — Senior Investigator
572:and neural precursor cells.
10:
2526:
2360:UCSF Bakar Cancer Hospital
2023:10.1016/j.chom.2016.02.012
1923:10.1016/j.stem.2011.05.010
1681:Alzheimer's Research Forum
1482:10.1016/j.cell.2021.04.025
1218:10.1016/j.cell.2010.11.001
509:. Showed a protein called
214:Mission Bay, San Francisco
200:
152:
2468:
2441:
2409:
2378:
2337:
2298:
2267:
2256:
2222:
2201:
923:January 15, Sam Hawgood.
496:neurodegenerative disease
139:
102:
74:
66:
58:
48:
40:
32:
23:
2230:UCSF School of Dentistry
2072:10.4049/jimmunol.2000513
929:Office of the Chancellor
636:Nobel Prize in Chemistry
429:Alzheimer's disease and
419:Alzheimer's disease and
235:Organizational structure
153:Not to be confused with
2410:Affiliated institutions
2245:UCSF School of Pharmacy
2235:UCSF School of Medicine
1781:10.1073/pnas.1121498109
1381:10.1126/science.1243640
1063:San Francisco Chronicle
506:Frontotemporal dementia
380:frontotemporal dementia
292:Virology and immunology
145:gladstoneinstitutes.org
2386:The Mpowerment Project
2250:UCSF Graduate Division
2240:UCSF School of Nursing
1114:www.accessdata.fda.gov
599:Translational research
409:and network disruption
269:Cardiovascular disease
2060:Journal of Immunology
1638:healthyliving.msn.com
846:"The Gladstone Story"
697:Former researchers:
590:Studying whether the
539:adult cells (such as
246:Institute of Virology
177:translational science
2423:Gladstone Institutes
1994:. December 18, 2013.
1657:. September 24, 2015
1476:(13): 3426–3437.e8.
852:on December 11, 2014
581:Huntington's disease
549:embryonic stem cells
523:Stem cell technology
450:Huntington's disease
384:Huntington's disease
366:Neurological disease
161:Gladstone Institutes
124:37.7676°N 122.3941°W
19:Gladstone Institutes
2345:UCSF Medical Center
1867:Scientific American
1772:2012PNAS..109.9223N
1373:2014Sci...343..428M
1324:10.1038/nature12940
1316:2014Natur.505..509D
903:www.bizjournals.com
810:. February 25, 2007
728:www.bizjournals.com
585:Alzheimer's disease
458:Parkinson's disease
407:Alzheimer's disease
376:Parkinson's disease
372:Alzheimer's disease
323:Leading the global
173:Alzheimer's disease
155:Gatestone Institute
120: /
20:
2275:Marin Commute Club
1819:The New York Times
1683:. November 6, 2012
1581:The New York Times
1444:ABC7 San Francisco
987:ABC7 San Francisco
605:drug repositioning
392:multiple sclerosis
129:37.7676; -122.3941
18:
2482:
2481:
2011:Cell Host Microbe
1766:(24): 9223–9225.
1714:(12): 1302–1309.
1622:. March 28, 2005.
1310:(7484): 509–514.
1020:(590): eabf7872.
672:Katherine Pollard
396:electrophysiology
264:Research programs
151:
150:
44:Deepak Srivastava
2517:
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2114:. April 9, 2018.
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1992:UC San Francisco
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1367:(6169): 428–32.
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483:researching how
454:inclusion bodies
421:apolipoprotein E
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1893:. June 7, 2012.
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1708:Nature Genetics
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1417:The Stem Cellar
1411:
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1296:
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1261:(10): 1555–63.
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1141:. July 12, 2011
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681:Leor Weinberger
632:Jennifer Doudna
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2151:External links
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2140:Nobelprize.org
2127:
2117:
2103:
2066:(2): 307–312.
2046:
1997:
1979:
1954:
1937:
1916:(6): 606–607.
1910:Cell Stem Cell
1896:
1879:
1850:
1839:. May 12, 2017
1824:
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1528:. May 17, 2021
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2017:(3): 280–91.
2016:
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1419:. May 8, 2020
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226:In 2011, the
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186:
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165:heart failure
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133:
105:
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96:United States
91:
85:
84:San Francisco
77:
73:
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53:
51:
47:
43:
39:
35:
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2461:(Chancellor)
2422:
2290:UCSF Library
2203:
2139:
2130:
2120:
2106:
2063:
2059:
2049:
2014:
2010:
2000:
1991:
1982:
1970:. Retrieved
1966:
1957:
1913:
1909:
1899:
1870:. Retrieved
1866:
1841:. Retrieved
1836:
1827:
1818:
1808:
1763:
1759:
1711:
1707:
1697:
1685:. Retrieved
1680:
1671:
1659:. Retrieved
1637:
1628:
1599:. Retrieved
1589:
1580:
1571:
1559:. Retrieved
1555:
1530:. Retrieved
1526:FiercePharma
1525:
1516:
1473:
1469:
1459:
1449:September 8,
1447:. Retrieved
1443:
1433:
1421:. Retrieved
1416:
1407:
1364:
1360:
1350:
1307:
1303:
1293:
1258:
1254:
1244:
1209:
1205:
1195:
1181:
1169:. Retrieved
1164:
1155:
1143:. Retrieved
1138:
1129:
1117:. Retrieved
1113:
1104:
1092:. Retrieved
1088:
1083:Leuty, Ron.
1078:
1066:. Retrieved
1062:
1052:
1017:
1013:
1002:
990:. Retrieved
986:
976:
964:. Retrieved
960:
951:
928:
918:
908:February 19,
906:. Retrieved
902:
892:
882:February 19,
880:. Retrieved
876:
866:
856:November 27,
854:. Retrieved
850:the original
840:
812:. Retrieved
807:
798:
788:February 19,
786:. Retrieved
782:
757:. Retrieved
753:
743:
733:February 19,
731:. Retrieved
727:
717:
696:
614:
602:
557:
553:
526:
504:
492:Inflammation
490:
472:Mitochondria
470:
445:
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400:
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346:
343:
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295:
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211:
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196:
189:
160:
159:
70:$ 80 million
15:
2459:Sam Hawgood
2449:Hugh Toland
2338:UCSF Health
2285:Mission Bay
2280:Mount Sutro
1872:October 27,
1843:October 26,
1687:October 27,
1661:October 27,
1601:October 27,
1561:October 27,
966:October 26,
814:October 27,
666:Melanie Ott
611:Researchers
545:pluripotent
541:fibroblasts
511:progranulin
501:conditions.
478:dysfunction
462:Lewy bodies
338:CD4 T-cells
306:hepatitis C
127: /
115:122°23′39″W
103:Coordinates
33:Established
2489:Categories
2215:California
2204:Located in
1532:October 7,
1423:August 30,
1094:August 20,
709:References
310:Zika virus
302:immunology
112:37°46′03″N
90:California
2223:Academics
2080:1550-6606
1490:0092-8674
1171:August 4,
1145:August 4,
1119:August 4,
1068:August 4,
577:iPS cells
485:autophagy
413:epileptic
41:President
2419:(Fresno)
2379:Projects
2299:Research
2098:32493814
2041:26962940
1932:21624802
1837:BioSpace
1800:22619323
1738:23104007
1508:33991487
1399:24356113
1342:24356306
1285:26321639
1255:Cell Rep
1236:21111238
1165:UCSF.edu
1044:33723017
992:July 15,
937:cite web
759:June 26,
476:synaptic
360:vaccines
314:COVID-19
298:virology
169:HIV/AIDS
75:Location
2473:Founded
2089:7343621
2032:4835240
1972:July 8,
1791:3386100
1768:Bibcode
1729:3510335
1499:8057738
1390:3976200
1369:Bibcode
1361:Science
1333:4047036
1312:Bibcode
1276:4565731
1227:3026834
1035:8128284
570:neurons
382:(FTD),
353:Moderna
201:History
140:Website
50:Faculty
2475:: 1864
2454:Police
2442:Topics
2306:Biohub
2268:Campus
2096:
2086:
2078:
2039:
2029:
1930:
1798:
1788:
1736:
1726:
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1304:Nature
1283:
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1234:
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1042:
1032:
877:SFGate
783:SFGate
575:Using
439:TDP-43
423:(apoE)
357:Pfizer
312:, and
67:Budget
325:iPrEx
59:Staff
2094:PMID
2076:ISSN
2037:PMID
1974:2021
1928:PMID
1874:2022
1845:2021
1796:PMID
1734:PMID
1689:2022
1663:2022
1603:2022
1563:2022
1534:2021
1504:PMID
1486:ISSN
1470:Cell
1451:2021
1425:2021
1395:PMID
1338:PMID
1281:PMID
1232:PMID
1206:Cell
1173:2021
1147:2021
1121:2021
1096:2021
1070:2021
1040:PMID
994:2021
968:2021
943:link
910:2020
884:2020
858:2014
816:2022
790:2020
761:2019
735:2020
583:and
494:and
474:and
355:and
300:and
171:and
36:1979
2084:PMC
2068:doi
2064:205
2027:PMC
2019:doi
1918:doi
1786:PMC
1776:doi
1764:109
1724:PMC
1716:doi
1494:PMC
1478:doi
1474:184
1385:PMC
1377:doi
1365:343
1328:PMC
1320:doi
1308:505
1271:PMC
1263:doi
1222:PMC
1214:doi
1210:143
1030:PMC
1022:doi
516:ALS
456:),
431:tau
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