747:
1184:(IVIG) are the two main immunotherapy treatments for GBS. Plasmapheresis attempts to reduce the body's attack on the nervous system by filtering antibodies out of the bloodstream. Similarly, administration of IVIG neutralizes harmful antibodies and inflammation. These two treatments are equally effective, but a combination of the two is not significantly better than either alone. Plasmapheresis speeds recovery when used within four weeks of the onset of symptoms. IVIG works as well as plasmapheresis when started within two weeks of the onset of symptoms, and has fewer complications. IVIG is usually used first because of its ease of administration and safety; the risks include occasionally causing
806:
1336:
worse prognosis. On the nerve conduction study, the presence of conduction block predicts poorer outcome at 6 months. In those who have received intravenous immunoglobulins, a smaller increase in IgG in the blood two weeks after administration is associated with poorer mobility outcomes at six months than those whose IgG level increased substantially. If the disease continues to progress beyond four weeks, or there are multiple fluctuations in the severity (more than two in eight weeks), the diagnosis may be
573:
1157:(BBE), for instance, is part of the group of conditions now regarded as forms of Miller Fisher syndrome (anti-GQ1b antibody syndrome), as well as a related condition labelled "acute ataxic hypersomnolence" where coordination problems and drowsiness are present but no muscle weakness can be detected. BBE is characterized by the rapid onset of ophthalmoplegia, ataxia, and disturbance of consciousness, and may be associated with absent or decreased tendon reflexes and as well as
448:
4279:"Recurrent and chronic relapsing Guillain-Barré polyneuritis by P.K. Thomas, R.G. Lascelles, J.F. Hallpike and R.L. Hewer. From the Institute of Neurology and National Hospital, Queen Square, the Royal National Orthopaedic Hospital, and Guy's Hospital, London. Brain 1969; 92: 589–606; with An acute axonal form of Guillain-Barré polyneuropathy by T.E. Feasby, J.J. Gilbert, W.F. Brown, C.F. Bolton, A.F. Hahn, W.F. Koopman and D.W. Zochodne. Brain 1986; 109: 1115–1126"
425:(paraplegia or paraparesis). Involvement of the muscles that control the bladder and anus is unusual. In total, about a third of people with Guillain–Barré syndrome continue to be able to walk. Once the weakness has stopped progressing, it persists at a stable level ("plateau phase") before improvement occurs. The plateau phase can take between two days and six months, but the most common duration is a week. Pain-related symptoms affect more than half, and include
1391:
667:(H1N1 A/NJ/76); 8.8 cases per million (0.0088 per 1000) recipients developed it as a complication. GBS cases occurred in 362 patients during the 6 weeks after influenza vaccination of 45 million persons, an 8.8-fold increase over normal rates. The 1976 swine flu vaccination-induced GBS was an outlier; small increases in incidence have been observed in subsequent vaccination campaigns, but not to the same extent. The
312:. Typically, both sides of the body are involved, and the initial symptoms are changes in sensation or pain often in the back along with muscle weakness, beginning in the feet and hands, often spreading to the arms and upper body. The symptoms may develop over hours to a few weeks. During the acute phase, the disorder can be life-threatening, with about 15% of people developing weakness of the
2488:
896:, GD1a, GT1a, and GQ1b, with different antiganglioside antibodies being associated with particular features; for instance, GQ1b antibodies have been linked with Miller Fisher variant GBS and related forms including Bickerstaff encephalitis. The production of these antibodies after an infection probably is the result of
378:, together with supportive care, will lead to good recovery in the majority of cases. Recovery may take weeks to years, with about a third having some permanent weakness. Globally, death occurs in approximately 7.5% of those affected. Guillain–Barré syndrome is rare, at 1 or 2 cases per 100,000 people every year.
986:. Characteristic findings in Guillain–Barré syndrome are an elevated protein level, usually greater than 0.55 g/L, and fewer than 10 white blood cells per cubic millimeter of fluid ("albuminocytological dissociation"). This pattern distinguishes Guillain–Barré syndrome from other conditions (such as
1020:
Formal criteria exist for each of the main subtypes of
Guillain–Barré syndrome (AIDP and AMAN/AMSAN, see below), but these may misclassify some cases (particularly where there is reversible conduction failure) and therefore changes to these criteria have been proposed. Sometimes, repeated testing may
719:
issued a warning to the patients and healthcare providers. The incidence of GBS following the vaccination with the Oxford–AstraZeneca vaccine was originally reported as being lower than the incidence of GBS following a COVID-19 infection. More recent studies, however, found no measurable link between
675:
did not cause a significant increase in cases. In fact, "studies found a small increase of approximately 1 case per million vaccines above the baseline rate, which is similar to that observed after administration of seasonal influenza vaccines over the past several years." Natural influenza infection
1335:
There is a variation in the rate and extent of recovery. The prognosis of
Guillain–Barré syndrome is determined mainly by age (those over 40 may have a poorer outcome), and by the severity of symptoms after two weeks. Furthermore, those who experienced diarrhea before the onset of the disease have a
1283:
Physiotherapy interventions include strength, endurance, and gait training with graduated increases in mobility, maintenance of posture and alignment as well as joint function. Occupational therapy aims to improve everyday function with domestic and community tasks as well as driving and work. Home
1029:
A number of subtypes of
Guillain–Barré syndrome are recognized. Despite this, many people have overlapping symptoms that can make the classification difficult in individual cases. All types have partial forms. For instance, some people experience only isolated eye-movement or coordination problems;
925:
It has been suggested that a poor injection technique may also cause a direct injury to the axillary nerves adjacent to the injection site in deltoid muscle that may lead to peripheral neuropathy. The consequent vaccine transfection and translation in the nerves may spur an immune response against
1373:
In
Western countries, the number of new episodes per year has been estimated to be between 0.89 and 1.89 cases per 100,000 people. Children and young adults are less likely to be affected than the elderly: the relative risk increases by 20% for every decade of life. Men are more likely to develop
1459:
The understanding of the disease mechanism of
Guillain–Barré syndrome has evolved in recent years. Development of new treatments has been limited since immunotherapy was introduced in the 1980s and 1990s. Current research is aimed at demonstrating whether some people who have received IVIg might
1450:
for vaccine safety in 2009, but is mainly intended for research. Plasma exchange was first used in 1978, and its benefit was confirmed in larger studies in 1985. Intravenous immunoglobulins were introduced in 1988, and studies in the early 1990s demonstrated that they were no less effective than
1438:
type in 1951 and made further contributions with another paper in 1957. Guillain had reported on some of these features before their full description in 1938. Further subtypes have been described since then, such as the form featuring pure ataxia and the type causing pharyngeal-cervical-brachial
1381:
The distribution of subtypes varies between countries. In Europe and the United States, 60–80% of people with
Guillain–Barré syndrome have the demyelinating subtype (AIDP), and AMAN affects only a small number (6–7%). In Asia and Central and South America, that proportion is significantly higher
404:
The first symptoms of
Guillain–Barré syndrome are numbness, tingling, and pain, alone or in combination. This is followed by weakness of the legs and arms that affects both sides equally and worsens over time. The weakness can take half a day to over two weeks to reach maximum severity, and then
1343:
In research studies, the outcome from an episode of
Guillain–Barré syndrome is recorded on a scale from 0 to 6, where 0 denotes completely healthy; 1 very minor symptoms but able to run; 2 able to walk but not to run; 3 requiring a stick or other support; 4 confined to bed or chair; 5 requiring
943:
are supportive investigations commonly performed in the diagnosis of GBS. Testing for antiganglioside antibodies is often performed, but their contribution to diagnosis is usually limited. Blood tests are generally performed to exclude the possibility of another cause for weakness, such as a
455:
In children, particularly those younger than six years old, the diagnosis can be difficult and the condition is often initially mistaken (sometimes for up to two weeks) for other causes of pains and difficulty walking, such as viral infections, or bone and joint problems.
471:, respectively). However, a small proportion have normal reflexes in affected limbs before developing areflexia, and some may have exaggerated reflexes. In the Miller Fisher variant of Guillain–Barré syndrome (see below), a triad of weakness of the eye muscles,
908:
class; only a small proportion of people also produce IgG antibodies against bacterial substance cell wall substances (e.g. lipooligosaccharides) that cross react with human nerve cell gangliosides. It is not currently known how this process escapes
1495:. An antibody targeted against the anti-GD3 antiganglioside antibody has shown benefit in laboratory research. Given the role of the complement system in GBS, it has been suggested that complement inhibitors (such as the drug
1331:
Guillain–Barré syndrome can lead to death as a result of many complications: severe infections, blood clots, and cardiac arrest likely due to autonomic neuropathy. Despite optimum care, this occurs in about 5% of cases.
934:
The diagnosis of
Guillain–Barré syndrome depends on findings such as rapid development of muscle paralysis, absent reflexes, absence of fever, and absence of a likely cause. Cerebrospinal fluid analysis (through a
4588:
4573:
813:
The nerve dysfunction in
Guillain–Barré syndrome is caused by an immune attack on the nerve cells of the peripheral nervous system and their support structures. The nerve cells have their body (the soma) in the
2470:
1382:(30–65%). This may be related to the exposure to different kinds of infection, but also the genetic characteristics of that population. Miller Fisher variant is thought to be more common in Southeast Asia.
914:
921:
simultaneously (heterodimeric binding) and that this determines the response. Furthermore, the development of pathogenic antibodies may depend on the presence of other strains of bacteria in the bowel.
1164:
Whether isolated acute sensory loss can be regarded as a form of Guillain–Barré syndrome is a matter of dispute; this is a rare occurrence compared to GBS with muscle weakness but no sensory symptoms.
842:) where the axon is exposed. Different types of Guillain–Barré syndrome feature different types of immune attacks. The demyelinating variant (AIDP, see below) features damage to the myelin sheath by
4117:[On a syndrome of radiculoneuritis with hypoalbuminemia of the cerebrospinal fluid without cellular reaction. Remarks on the clinical and graphical characters of the tendon reflexes].
683:. On March 24, 2021, after reviewing several post-marketing observational studies, where an increased risk of Guillain–Barré syndrome was observed after 42 days following vaccination with the
405:
becomes steady. In one in five people, the weakness continues to progress for as long as four weeks. The muscles of the neck may also be affected, and about half experience involvement of the
1424:
diagnosed two soldiers with the illness and described the key diagnostic abnormality—albuminocytological dissociation—of increased spinal fluid protein concentration but a normal cell count.
637:
have been associated with GBS. GBS is known to occur after influenza, and influenza vaccination has been demonstrated to be associated with a reduced risk. The tropical flaviviral infections
4115:"Sur un syndrome de radiculonévrite avec hyperalbuminose du liquide céphalo-rachidien sans réaction cellulaire. Remarques sur les caractères cliniques et graphiques des réflexes tendineux"
1017:(EMG) and nerve conduction studies may be performed. In the first two weeks, these investigations may not show any abnormality. Neurophysiology studies are not required for the diagnosis.
436:
Many people with Guillain–Barré syndrome have experienced the signs and symptoms of an infection in the 3–6 weeks before the onset of the neurological symptoms. This may consist of
676:
is a stronger risk factor for the development of GBS than is influenza vaccination and the vaccination reduced the risk of GBS overall by lowering the risk of catching influenza.
971:, this may be indicative of GBS. In children, this feature is present in 95% of scans, but it is not specific to Guillain–Barré syndrome, so other confirmation is also needed.
3833:
5243:
4728:
2989:
1292:
input may be required in those with speech and swallowing problems, as well as to support communication in those who require ongoing breathing support (often through a
539:, is affected in two-thirds of people with Guillain–Barré syndrome, but the impact is variable. Twenty percent may experience severe blood-pressure fluctuations and
3090:"Inadvertent injection of COVID-19 vaccine into deltoid muscle vasculature may result in vaccine distribution to distance tissues and consequent adverse reactions"
998:. Elevated CSF protein levels are found in approximately 50% of patients in the first 3 days after onset of weakness, which increases to 80% after the first week.
953:
1397:, together with Barré and Strohl, described two cases of self-limiting acute paralysis with peculiar changes in the cerebrospinal fluid. He succeeded his teacher
1351:(HRQL) after an attack of Guillain–Barré syndrome can be significantly impaired. About a fifth are unable to walk unaided after six months, and many experience
900:, where the immune system is reacting to microbial substances, but the resultant antibodies also react with substances occurring naturally in the body. After a
5058:
1460:
benefit from a second course if the antibody levels measured in blood after treatment have shown only a small increase. Studies of the immunosuppressive drugs
869:
Various antibodies directed at nerve cells have been reported in Guillain–Barré syndrome. In the axonal subtype, these antibodies have been shown to bind to
1161:. The course of the disease is usually monophasic, but recurrent episodes have been reported. MRI abnormalities in the brainstem have been reported in 11%.
1137:
This variant occurs more commonly in men than in women (2:1 ratio). Cases typically occur in the spring and the average age of occurrence is 43 years old.
1083:
Rare in Europe and North America, a substantial proportion (30–65%) in Asia and Central and South America; sometimes called "Chinese paralytic syndrome"
734:, an antidepressant, had a very favorable safety profile but as a result of rare case reports of Guillain–Barré syndrome was withdrawn from the market.
590:
Two-thirds of people with Guillain–Barré syndrome have experienced an infection before the onset of the condition. Most commonly, these are episodes of
1368:
5090:
4351:"Guillain-Barré syndrome and Fisher syndrome: case definitions and guidelines for collection, analysis, and presentation of immunization safety data"
1337:
5722:
2842:"Peripheral neuropathy in COVID-19 is due to immune-mechanisms, pre-existing risk factors, anti-viral drugs, or bedding in the Intensive Care Unit"
3562:"Practice parameter: immunotherapy for Guillain-Barré syndrome: report of the Quality Standards Subcommittee of the American Academy of Neurology"
2713:
1256:(ADLs). Studies into the subject have been limited, but it is likely that intensive rehabilitation improves long-term symptoms. Teams may include
982:
envelops the brain and the spine, and lumbar puncture or spinal tap is the removal of a small amount of fluid using a needle inserted between the
723:
COVID-19 has been reported as causing peripheral neuropathy and more recently some evidence of aggravation of autoimmune disorders including GBS.
5872:
5236:
4721:
1626:
1252:
Following the acute phase, around 40% of people require intensive rehabilitation with the help of a multidisciplinary team to focus on improving
1001:
Repeating the lumbar puncture during the disease course is not recommended. The protein levels may rise after treatment has been administered.
3280:
Uncini A, Kuwabara S (August 2012). "Electrodiagnostic criteria for Guillain-Barrè syndrome: a critical revision and the need for an update".
5867:
5852:
4099:
1300:. Psychologists may provide counselling and support. Psychological interventions may also be required for anxiety, fear, and depression.
1557:
1323:
by a range of organisations under the umbrella of EPODIN (European Patient Organization for Disimmune & Inflammatory Neuropathies).
5229:
4714:
3416:
Wakerley, BR; Soon, D; Yuki, N (2013). "Atypical Bickerstaff brainstem encephalitis: ataxic hypersomnolence without ophthalmoplegia".
351:. The diagnosis is usually based on the signs and symptoms through the exclusion of alternative causes and supported by tests such as
5877:
5805:
5800:
5401:
4114:
1634:
963:
of the spinal cord is performed to distinguish between Guillain–Barré syndrome and other conditions causing limb weakness, such as
1875:
Eldar AH, Chapman J (April 2014). "Guillain Barré syndrome and other immune mediated neuropathies: diagnosis and classification".
612:
or CMV infections develop Guillain–Barré syndrome (0.25–0.65 per 1000 and 0.6–2.2 per 1000 episodes, respectively). The strain of
5756:
5030:
4540:
4144:
Fisher M (July 1956). "An unusual variant of acute idiopathic polyneuritis (syndrome of ophthalmoplegia, ataxia and areflexia)".
2816:
1154:
1013:
can exclude other causes of acute muscle weakness, as well as distinguish the different types of Guillain–Barré syndrome. Needle
712:
3813:
35:
Guillain–Barré–Strohl syndrome, Landry's paralysis, postinfectious polyneuritis, Acute Inflammatory Demyelinating Polyneuropathy
5578:
2324:
Lehmann HC, Hartung HP, Kieseier BC, Hughes RA (September 2010). "Guillain-Barré syndrome after exposure to influenza virus".
3330:
Wakerley BR, Uncini A, Yuki N (September 2014). "Guillain-Barré and Miller Fisher syndromes--new diagnostic classification".
1825:
van Doorn PA, Ruts L, Jacobs BC (October 2008). "Clinical features, pathogenesis, and treatment of Guillain-Barré syndrome".
1277:
707:, and may be a potential neurological complication of the disease. GBS has been reported as a very rare side effect of the
1475:
An animal model (experimental autoimmune neuritis in rats) is often used for studies, and some agents have shown promise:
359:. There are a number of subtypes based on the areas of weakness, results of nerve conduction studies, and the presence of
5038:
4603:
2234:
Carod-Artal FJ, Wichmann O, Farrar J, Gascón J (September 2013). "Neurological complications of dengue virus infection".
720:
COVID-19 infection and GBS, while correlations with a first dose of AstraZeneca or Janssen vaccines were still positive.
347:
insulation. Sometimes this immune dysfunction is triggered by an infection or, less commonly, by surgery, and rarely, by
3847:
Khan F, Ng L, Amatya B, Brand C, Turner-Stokes L (October 2010). "Multidisciplinary care for Guillain-Barré syndrome".
2740:"Autoimmune damage to the nerves following Covid vaccines: EMA issued warning to patients and healthcare professionals"
1435:
2441:
1402:
5795:
5573:
4524:
1551:
1465:
437:
3814:"Rehabilitation interventions in patients with acute demyelinating inflammatory polyneuropathy: a systematic review"
3373:
Mori M, Kuwabara S, Yuki N (January 2012). "Fisher syndrome: clinical features, immunopathogenesis and management".
913:
to gangliosides, which is meant to suppress the production of antibodies against the body's own substances. Not all
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4888:
1359:
and difficulty with work, education, hobbies and social activities. HRQL improves significantly in the first year.
5614:
5476:
5568:
4551:
Information on GBS from NGO EPODIN (European Patient Organization for Disimmune & Inflammatory Neuropathies)
3053:
Willison HJ, Goodyear CS (September 2013). "Glycolipid antigens and autoantibodies in autoimmune neuropathies".
926:
nerve cells potentially causing an autoimmune nerve damage, leading to conditions like Guillain–Barré syndrome.
598:. In many cases, the exact nature of the infection can be confirmed. Approximately 30% of cases are provoked by
5842:
5182:
4991:
476:
1510:. If the coonhound has not been around raccoons, the disease is called acute idiopathic polyradiculoneuritis.
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5053:
1488:
1308:
1074:
480:
5847:
5751:
2840:
Finsterer, Josef; Scorza, Fulvio Alexandre; Scorza, Carla Alessandra; Fiorini, Ana Claudia (19 July 2021).
1348:
577:
548:
1571:
491:
A quarter of all people with Guillain–Barré syndrome develop weakness of the breathing muscles leading to
5653:
5456:
5063:
5043:
4310:
Asbury AK, Cornblath DR (1990). "Assessment of current diagnostic criteria for Guillain-Barré syndrome".
1181:
595:
516:
2658:"Guillain-Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases"
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5362:
5192:
1253:
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Isolated muscle weakness without sensory symptoms in less than 10%; cranial nerve involvement uncommon
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5117:
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Ongoing specialist community support, information, advice, and guidance is available from a range of
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alone have not been found to be effective in speeding recovery and could potentially delay recovery.
917:
cause disease, and it has recently been suggested that some antibodies bind to more than one type of
716:
679:
In the United States, GBS after seasonal influenza vaccination is listed on the federal government's
668:
559:. Autonomic nervous system involvement can affect even those who do not have severe muscle weakness.
309:
663:
An increased incidence of Guillain–Barré syndrome followed influenza immunization that followed the
5628:
5397:
5383:
5143:
5122:
4614:
2990:"The Rise and Sudden Fall of Zimelidine: The First SSRI | 2020-11-16 | CARLAT PUBLISHING"
708:
528:
460:
325:
3994:
Darweesh SK, Polinder S, Mulder MJ, Baena CP, van Leeuwen N, Franco OH, et al. (March 2014).
3007:
Kuwabara S, Yuki N (December 2013). "Axonal Guillain-Barré syndrome: concepts and controversies".
1502:
In animals it is called acute polyradiculoneuritis or "coonhound paralysis", and may onset in the
1240:
While pain is common in people with Guillain–Barré syndrome, studies comparing different types of
1060:
Sensory symptoms and muscle weakness, often with cranial nerve weakness and autonomic involvement
5857:
5501:
5264:
4950:
4844:
4541:
Information on GBS from UK Charity GAIN (Guillain–Barré and Associated Inflammatory Neuropathies)
3560:
Hughes RA, Wijdicks EF, Barohn R, Benson E, Cornblath DR, Hahn AF, et al. (September 2003).
1409:
1304:
964:
882:
664:
658:
182:
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Walgaard C, Jacobs BC, van Doorn PA (March 2011). "Emerging drugs for Guillain-Barré syndrome".
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389:
282:
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5018:
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4914:
4896:
4867:
4801:
4778:
2605:
Paterson RW, Brown RL, Benjamin L, Nortley R, Wiethoff S, Bharucha T, et al. (July 2020).
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Toscano G, Palmerini F, Ravaglia S, Ruiz L, Invernizzi P, Cuzzoni MG, et al. (June 2020).
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1442:
Diagnostic criteria were developed in the late 1970s after the series of cases associated with
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352:
317:
214:
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2656:
Abu-Rumeileh, Samir; Abdelhak, Ahmed; Foschi, Matteo; Tumani, Hayrettin; Otto, Markus (2021).
1541:
1224:(NIF). An FVC of less than 15 mL per kilogram body weight or an NIF of less than 60
873:, a group of substances found in peripheral nerves. A ganglioside is a molecule consisting of
805:
503:
in the blood. This life-threatening scenario is complicated by other medical problems such as
5202:
5077:
4982:
4811:
4493:
2607:"The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings"
1217:
680:
633:
605:
343:
in which the body's immune system mistakenly attacks the peripheral nerves and damages their
3950:
Hughes RA, Swan AV, Raphaël JC, Annane D, van Koningsveld R, van Doorn PA (September 2007).
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5785:
5769:
5679:
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5378:
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Hughes, Richard Ac; Brassington, Ruth; Gunn, Angela A.; van Doorn, Pieter A. (2016-10-24).
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Spasovski G, Vanholder R, Allolio B, Annane D, Ball S, Bichet D, et al. (March 2014).
2947:
2766:"Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection"
2505:
Ellul MA, Benjamin L, Singh B, Lant S, Michael BD, Easton A, et al. (September 2020).
2195:"Guillain-Barre Syndrome, Influenza, and Influenza Vaccination: The Epidemiologic Evidence"
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this is provided by GAIN (Guillain–Barré and Associated Inflammatory Neuropathies), in the
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8:
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4230:"Brain-stem encephalitis; further observations on a grave syndrome with benign prognosis"
3996:"Health-related quality of life in Guillain-Barré syndrome patients: a systematic review"
3603:"Intravenous immunoglobulins: in-depth review of excipients and acute kidney injury risk"
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1209:
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Other diagnostic entities are often included in the spectrum of Guillain–Barré syndrome.
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540:
492:
356:
340:
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2951:
2144:
van Doorn PA, Kuitwaard K, Walgaard C, van Koningsveld R, Ruts L, Jacobs BC (May 2010).
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van den Berg B, Walgaard C, Drenthen J, Fokke C, Jacobs BC, van Doorn PA (August 2014).
1665:"Population incidence of Guillain-Barré syndrome: a systematic review and meta-analysis"
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Sejvar JJ, Kohl KS, Gidudu J, Amato A, Bakshi N, Baxter R, et al. (January 2011).
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involved may determine the risk of GBS; different forms of the bacteria have different
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2797:
2714:"COVID-19 Vaccine Janssen: Guillain-Barré syndrome listed as a very rare side effect"
2695:
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2587:
2538:
2423:
2382:
2361:"Invited Commentary: Influenza Vaccine and Guillain-Barre Syndrome--Is There a Risk?"
2341:
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2216:
2175:
2117:
2096:"Bickerstaff brainstem encephalitis and Fisher syndrome: anti-GQ1b antibody syndrome"
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2013:
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463:, characteristic features are the reduced strength of muscles and reduced or absent
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4465:
4457:
4430:
4410:
4362:
4315:
4290:
4249:
4241:
4200:
4192:
4153:
4052:
4007:
3963:
3856:
3852:
3777:
3765:
3761:
3720:
3712:
3671:
3659:
3655:
3614:
3573:
3529:
3525:
3521:
3480:
3472:
3425:
3402:
3382:
3339:
3289:
3241:
3195:
3158:
3101:
3062:
3016:
2955:
2910:
2902:
2853:
2787:
2779:
2685:
2669:
2628:
2618:
2577:
2569:
2528:
2518:
2413:
2372:
2333:
2293:
2243:
2206:
2165:
2157:
2107:
2043:
2005:
1923:
1884:
1854:
1834:
1778:
1684:
1676:
1413:
1394:
1257:
1014:
983:
905:
859:
843:
830:, where the impulse is transferred to the muscle. Axons are wrapped in a sheath of
823:
623:
Links between other infections and GBS are less certain. Two other herpes viruses (
433:, and pain in the head and neck relating to irritation of the lining of the brain.
418:
385:
277:
100:
94:
54:
4366:
4072:
3476:
1114:
Weakness particularly of the throat muscles, and face, neck, and shoulder muscles
620:
on their surface, and some may induce illness (see below) while others will not.
5704:
5674:
5558:
5486:
5340:
5293:
4619:
4414:
3293:
2770:
2739:
2047:
1888:
1443:
1189:
952:
is often encountered in Guillain–Barré syndrome. This has been attributed to the
936:
839:
776:
692:
591:
410:
228:
218:
148:
48:
4674:
4157:
4029:
3199:
1446:
vaccination. These were refined in 1990. The case definition was revised by the
1421:
854:); this process is preceded by activation of a group of blood proteins known as
393:
5588:
5542:
5335:
5048:
5014:
4862:
4751:
2783:
2673:
2278:
1320:
1312:
1177:
1158:
684:
536:
500:
464:
406:
375:
364:
333:
236:
203:
Typically triggered by an infection; occasionally by surgery and by vaccination
4668:
4630:
4582:
4446:"Two cases of acute polyradiculoneuritis in dogs consuming a raw poultry diet"
3716:
3343:
2161:
1783:
1766:
5836:
5763:
5355:
5100:
4960:
4924:
4671:
4043:
Goetz CG (May 1998). "Georges Guillain's neurologic exploration of America".
3773:
3667:
3429:
3115:
3066:
2681:
2492:
2279:"Zika virus: a previously slow pandemic spreads rapidly through the Americas"
2112:
2095:
1427:
1375:
1316:
991:
783:
305:
4245:
4130:
2959:
2623:
1212:. The need for ventilatory support can be anticipated by measurement of two
5658:
5448:
5330:
5319:
5127:
5073:
4906:
4826:
4770:
4479:
4422:
4374:
4295:
4278:
4263:
4214:
4165:
4021:
3977:
3968:
3951:
3879:"GAIN Charity: Guillain-Barré Syndrome (GBS) & Associated Neuropathies"
3864:
3829:
3791:
3734:
3685:
3628:
3587:
3543:
3494:
3437:
3394:
3351:
3301:
3253:
3172:
3123:
3074:
3028:
2967:
2867:
2801:
2699:
2642:
2591:
2542:
2427:
2386:
2345:
2307:
2255:
2220:
2179:
2121:
2055:
2017:
1937:
1896:
1846:
1792:
1767:"Guillain-Barré syndrome: pathogenesis, diagnosis, treatment and prognosis"
1698:
1480:
1398:
1352:
1293:
1265:
949:
831:
788:
771:
766:
638:
572:
552:
468:
321:
4327:
4319:
4196:
4064:
4056:
3207:
2924:
2009:
447:
5345:
5325:
5309:
4793:
4649:
4461:
3578:
3561:
3147:"Clinical practice guideline on diagnosis and treatment of hyponatraemia"
3089:
2906:
2573:
2418:
2401:
2377:
2360:
2298:
2211:
2194:
2143:
995:
945:
870:
815:
382:
348:
4550:
3163:
3146:
5104:
4839:
4816:
4680:
4012:
3995:
3459:
Liu, Shuang; Dong, Chaoling; Ubogu, Eroboghene Ekamereno (2021-06-02).
3386:
3245:
1496:
1492:
1472:(IFN-β) have not demonstrated benefit to support their widespread use.
1430:
described the variant that bears his name in 1956. British neurologist
1213:
968:
851:
756:
731:
642:
532:
422:
329:
69:
4736:
4565:
4119:
Bulletins et Mémoires de la Société des Médecins des Hôpitaux de Paris
3619:
3602:
2463:
1680:
1244:
are insufficient to make a recommendation as to which should be used.
1140:
Generally normal, sometimes discrete changes in sensory conduction or
5197:
4660:
1503:
1297:
1285:
1241:
1185:
746:
504:
426:
414:
301:
243:
165:
4350:
495:, the inability to breathe adequately to maintain healthy levels of
339:
Although the cause is unknown, the underlying mechanism involves an
4694:
1507:
1390:
1276:. The team usually works under the supervision of a neurologist or
1141:
987:
874:
863:
751:
704:
544:
441:
4444:
Kim, Se-Hoon; Choi, Seo-In; Song, Kun-Ho; Seo, Kyoung-Won (2021).
2938:
Carlsson A (November 2001). "A paradigm shift in brain research".
1103:
Axonal polyneuropathy, reduced or absent sensory action potential
604:
bacteria, which cause diarrhea. A further 10% are attributable to
177:
Muscle weakness beginning in the feet and hands, usually ascending
5268:
2491:
This article incorporates text from this source, which is in the
1764:
1484:
1273:
918:
430:
4608:
4545:
3952:"Immunotherapy for Guillain-Barré syndrome: a systematic review"
2655:
2402:"Principal controversies in vaccine safety in the United States"
5637:
4577:
3750:"Pharmacological treatment for pain in Guillain-Barré syndrome"
3144:
2817:"Rise in Guillain-Barré syndrome following AstraZeneca vaccine"
2233:
1131:
1057:
Acute inflammatory demyelinating polyradiculoneuropathy (AIDP)
878:
847:
835:
793:
649:
infection has been found to be more common in people with GBS.
508:
496:
472:
344:
269:
4519:. New York: Demos; ANN Press (American Academy of Neurology).
3878:
3641:
2034:
Ryan MM (December 2013). "Pediatric Guillain-Barré syndrome".
1134:, eye muscle weakness, areflexia but usually no limb weakness
586:, which triggers about 30% of cases of Guillain–Barré syndrome
80:
63:
5604:
5272:
5013:
4546:
Information on GBS from NGO GBS/CIDP Foundation International
1311:(NGOs), and Patient Advisory Groups around the world. In the
1097:
Severe muscle weakness similar to AMAN but with sensory loss
531:, which is involved in the control of body functions such as
126:
5251:
3902:
3232:
Rinaldi S (June 2013). "Update on Guillain-Barré syndrome".
2839:
2604:
2555:
2323:
1319:
it is provided by GBS/CIDP Foundation International, and in
451:
Various patterns of manifestation of Guillain–Barré syndrome
3993:
1996:
Yuki N, Hartung HP (June 2012). "Guillain-Barré syndrome".
819:
761:
479:
is normally unaffected in Guillain–Barré syndrome, but the
135:
106:
83:
3926:
3559:
2889:
Fagius J, Osterman PO, Sidén A, Wiholm BE (January 1985).
1439:
weakness. The axonal subtype was first described in 1986.
1296:). Nutritional support may be provided by the team and by
16:
Autoimmune disease affecting the peripheral nervous system
2888:
2146:"IVIG treatment and prognosis in Guillain-Barré syndrome"
893:
695:
to include warnings for risk of Guillain–Barré syndrome.
688:
645:
have also been associated with episodes of GBS. Previous
187:
Breathing difficulties, heart and blood pressure problems
115:
103:
66:
60:
3818:
European Journal of Physical and Rehabilitation Medicine
3748:
Liu, Jia; Wang, Lu-Ning; McNicol, Ewan D. (2015-04-09).
3510:"Intravenous immunoglobulin for Guillain-Barré syndrome"
1662:
698:
4400:
3949:
3186:
Ropper AH (April 1992). "The Guillain-Barré syndrome".
3048:
3046:
2891:"Guillain-Barré syndrome following zimeldine treatment"
2399:
1909:
1086:
Axonal polyneuropathy, normal sensory action potential
5059:
Hereditary neuropathy with liability to pressure palsy
3452:
2504:
1232:
are considered markers of severe respiratory failure.
1120:
Generally normal, sometimes axonal neuropathy in arms
608:(CMV, HHV-5). Despite this, only very few people with
4348:
2471:"New safety communication regarding Shingrix vaccine"
2193:
Vellozzi, C.; Iqbal, S.; Broder, K. (15 April 2014).
483:
subtype may feature drowsiness, sleepiness, or coma.
370:
In those with severe weakness, prompt treatment with
118:
4555:
3043:
2558:"Guillain-Barré Syndrome Associated with SARS-CoV-2"
1910:
Willison HJ, Jacobs BC, van Doorn PA (August 2016).
1034:
and have similar antiganglioside antibody patterns.
691:
required safety label changes from the manufacturer
519:
in 60% of those who require artificial ventilation.
132:
123:
112:
77:
4517:
Guillain–Barré syndrome: from diagnosis to recovery
4112:
3508:Hughes RA, Swan AV, van Doorn PA (September 2014).
3507:
2400:DeStefano F, Bodenstab HM, Offit PA (August 2019).
2192:
1824:
1760:
1758:
1756:
1754:
1752:
1750:
1748:
1746:
1744:
1742:
1740:
1738:
1736:
1734:
1732:
1730:
1728:
129:
109:
74:
57:
3329:
2895:Journal of Neurology, Neurosurgery, and Psychiatry
2100:Journal of Neurology, Neurosurgery, and Psychiatry
2089:
2087:
2085:
2083:
2081:
2079:
2077:
2075:
2073:
1726:
1724:
1722:
1720:
1718:
1716:
1714:
1712:
1710:
1708:
1663:Sejvar JJ, Baughman AL, Wise M, Morgan OW (2011).
1094:Acute motor and sensory axonal neuropathy (AMSAN)
5091:Chronic inflammatory demyelinating polyneuropathy
4178:
3846:
1338:chronic inflammatory demyelinating polyneuropathy
858:. In contrast, the axonal variant is mediated by
551:. Other associated problems are abnormalities in
5834:
5723:Transfusion-associated graft-versus-host disease
4092:Gazette Hebdomadaire de Médecine et de Chirurgie
3415:
3372:
3052:
1264:, speech language pathologists, social workers,
409:that supply the head and face; this may lead to
4396:
4394:
4392:
4390:
4388:
4386:
4384:
4309:
3989:
3987:
3698:
3325:
3323:
3321:
3319:
2139:
2137:
2135:
2133:
2131:
2093:
2070:
1705:
1412:first described the disorder in 1859. In 1916,
954:inappropriate secretion of antidiuretic hormone
904:infection, the body produces antibodies of the
881:-type sugars and containing various numbers of
475:, as well as absent reflexes can be found. The
328:, which can lead to dangerous abnormalities in
4514:
4443:
3747:
3279:
3227:
3225:
3223:
3221:
3219:
3217:
2319:
2317:
1820:
1818:
1816:
1814:
1812:
1810:
5237:
4722:
3692:
3644:"Corticosteroids for Guillain-Barré syndrome"
3275:
3273:
3271:
2393:
4381:
4106:
3984:
3458:
3316:
3006:
3000:
2276:
2128:
1874:
1658:
1656:
1654:
1652:
1123:Mostly GT1a, occasionally GQ1b, rarely GD1a
890:against which antibodies have been described
4227:
3849:The Cochrane Database of Systematic Reviews
3807:
3805:
3803:
3801:
3754:The Cochrane Database of Systematic Reviews
3648:The Cochrane Database of Systematic Reviews
3514:The Cochrane Database of Systematic Reviews
3214:
2314:
2029:
2027:
1995:
1991:
1989:
1987:
1985:
1983:
1981:
1979:
1977:
1975:
1973:
1971:
1969:
1967:
1903:
1870:
1868:
1866:
1864:
1807:
1543:Ferri's Clinical Advisor 2017: 5 Books in 1
1369:List of people with Guillain–Barré syndrome
950:abnormally low level of sodium in the blood
5244:
5230:
4729:
4715:
3811:
3594:
3461:"Immunotherapy of Guillain-Barré syndrome"
3268:
1965:
1963:
1961:
1959:
1957:
1955:
1953:
1951:
1949:
1947:
1621:
1619:
1617:
1615:
1613:
1611:
967:. If an MRI scan shows enhancement of the
956:, leading to relative retention of water.
703:GBS has been reported in association with
4469:
4294:
4253:
4204:
4011:
3967:
3781:
3724:
3675:
3618:
3577:
3555:
3553:
3533:
3484:
3162:
3105:
2914:
2857:
2791:
2689:
2632:
2622:
2581:
2532:
2522:
2417:
2376:
2297:
2227:
2210:
2169:
2111:
1927:
1782:
1688:
1649:
1609:
1607:
1605:
1603:
1601:
1599:
1597:
1595:
1593:
1591:
1546:. Elsevier Health Sciences. p. 529.
1535:
1533:
1531:
1529:
1527:
1525:
1523:
4276:
4088:"Note sur la paralysie ascendante aiguë"
4000:Journal of the Peripheral Nervous System
3798:
3366:
3234:Journal of the Peripheral Nervous System
3087:
2937:
2352:
2024:
1861:
1389:
1374:Guillain–Barré syndrome than women; the
1344:long-term respiratory support; 6 death.
1195:
1063:Most common in Europe and North America
804:
571:
522:
446:
5757:Allergic bronchopulmonary aspergillosis
4181:"Mesencephalitis and rhombencephalitis"
4179:Bickerstaff ER, Cloake PC (July 1951).
3465:Human Vaccines & Immunotherapeutics
3231:
2507:"Neurological associations of COVID-19"
1944:
1572:"Definition of GUILLAIN-BARRÉ SYNDROME"
1011:nerve conduction of electrical impulses
866:without direct lymphocyte involvement.
529:autonomic or involuntary nervous system
381:The syndrome is named after the French
5873:Syndromes affecting the nervous system
5835:
4143:
4113:Guillain G, Barré J, Strohl A (1916).
4085:
3701:"Guillain-Barré syndrome and variants"
3600:
3550:
3185:
2882:
2763:
2358:
1588:
1520:
1454:
809:Guillain–Barré syndrome – nerve damage
486:
392:, who, together with French physician
5579:Post-streptococcal glomerulonephritis
5225:
5164:
5012:
4749:
4710:
4450:Journal of Veterinary Medical Science
4042:
2706:
1539:
1506:7 to 10 days after transmission from
1111:Pharyngeal-cervical-brachial variant
1030:these are thought to be a subtype of
699:COVID-19 infection or vaccine related
399:
147:
3699:Dimachkie MM, Barohn RJ (May 2013).
2732:
2277:Gatherer D, Kohl A (February 2016).
2033:
1627:"Guillain–Barré Syndrome Fact Sheet"
1188:, or in rare cases, kidney failure.
1155:Bickerstaff's brainstem encephalitis
1024:
994:) in which both the protein and the
713:Oxford–AstraZeneca COVID-19 vaccines
5868:Peripheral nervous system disorders
5853:Cytomegalovirus-associated diseases
4146:The New England Journal of Medicine
3812:Khan F, Amatya B (September 2012).
3188:The New England Journal of Medicine
2814:
2562:The New England Journal of Medicine
1998:The New England Journal of Medicine
1378:for men is 1.78 compared to women.
946:low level of potassium in the blood
673:pandemic swine flu virus H1N1/PDM09
411:weakness of the muscles of the face
396:, described the condition in 1916.
13:
4750:
4508:
3375:Expert Review of Neurotherapeutics
2094:Shahrizaila N, Yuki N (May 2013).
1637:from the original on 5 August 2016
1004:
888:groups. The key four gangliosides
838:. Between Schwann cells are gaps (
737:
567:
543:, sometimes to the point that the
481:Bickerstaff brainstem encephalitis
14:
5889:
5796:Autoimmune polyendocrine syndrome
4534:
3907:GBS/CIDP Foundation International
3151:European Journal of Endocrinology
2475:U.S. Food and Drug Administration
1466:brain-derived neurotrophic factor
1401:as professor of neurology at the
1247:
438:upper respiratory tract infection
5878:Diseases named after discoverers
5433:Hemolytic disease of the newborn
4889:lateral cutaneous nerve of thigh
4403:Expert Opinion on Emerging Drugs
4277:Compston, Alastair (July 2016).
4102:from the original on 2017-02-27.
3836:from the original on 2015-08-26.
3107:10.1136/postgradmedj-2021-141119
2486:
2365:American Journal of Epidemiology
1560:from the original on 2016-08-21.
1340:, which is treated differently.
1200:Respiratory failure may require
1172:
745:
652:
541:irregularities in the heart beat
99:
53:
5615:Subacute bacterial endocarditis
5477:Immune thrombocytopenic purpura
4515:Steinberg GJ, Parry JS (2006).
4486:
4437:
4342:
4303:
4270:
4221:
4172:
4137:
4079:
4036:
3943:
3919:
3895:
3871:
3840:
3741:
3635:
3501:
3409:
3179:
3138:
3081:
2982:
2931:
2859:10.1590/0004-282X-ANP-2021-0030
2833:
2808:
2757:
2649:
2598:
2549:
2498:
2434:
2326:The Lancet. Infectious Diseases
2286:The Journal of General Virology
2270:
2186:
1362:
1288:, and splints may be provided.
1089:GM1a/b, GD1a & GalNac-GD1a
974:
864:cell membrane covering the axon
726:
517:bleeding in the digestive tract
363:. It is classified as an acute
5183:Complex regional pain syndrome
4992:Template:Cranial nerve disease
3857:10.1002/14651858.CD008505.pub2
3766:10.1002/14651858.CD009950.pub3
3660:10.1002/14651858.CD001446.pub5
3607:American Journal of Nephrology
3526:10.1002/14651858.CD002063.pub6
3088:Merchant, Hamid (2022-07-01).
2150:Journal of Clinical Immunology
1564:
1349:health-related quality of life
1204:and breathing support through
1:
5695:Postorgasmic illness syndrome
5054:Hereditary spastic paraplegia
4367:10.1016/j.vaccine.2010.06.003
3477:10.1080/21645515.2018.1493415
3418:J Neurol Neurosurg Psychiatry
3021:10.1016/S1474-4422(13)70215-1
2846:Arquivos de Neuro-Psiquiatria
2524:10.1016/S1474-4422(20)30221-0
2442:"Vaccine Injury Table - HRSA"
2338:10.1016/S1473-3099(10)70140-7
2248:10.1016/S1474-4422(13)70150-9
2036:Current Opinion in Pediatrics
1929:10.1016/S0140-6736(16)00339-1
1839:10.1016/S1474-4422(08)70215-1
1513:
1075:Acute motor axonal neuropathy
1066:Demyelinating polyneuropathy
800:Structure of a typical neuron
473:abnormalities in coordination
256:2 per 100,000 people per year
5752:Hypersensitivity pneumonitis
4415:10.1517/14728214.2011.531699
4228:Bickerstaff ER (June 1957).
3294:10.1016/j.clinph.2012.01.025
3094:Postgraduate Medical Journal
2406:Clinical Infectious Diseases
2199:Clinical Infectious Diseases
2048:10.1097/MOP.0b013e328365ad3f
1889:10.1016/j.autrev.2014.01.033
1491:enzyme), and the heart drug
1326:
1309:Non-Government Organisations
1216:-based breathing tests: the
1167:
929:
578:scanning electron microscope
440:(rhinitis, sore throat), or
7:
5818:Systemic autoimmune disease
5654:Allergic contact dermatitis
5574:Hypersensitivity vasculitis
5457:Autoimmune hemolytic anemia
5064:Familial amyloid neuropathy
5039:Charcot–Marie–Tooth disease
4158:10.1056/NEJM195607122550201
3200:10.1056/NEJM199204233261706
1410:Jean-Baptiste Octave Landry
1280:directing treatment goals.
1270:allied health professionals
1182:intravenous immunoglobulins
1052:Antiganglioside antibodies
862:and complement against the
818:and a long projection (the
596:respiratory tract infection
419:weakness of the eye muscles
372:intravenous immunoglobulins
248:Weeks to years for recovery
10:
5894:
5324:common allergies include:
5193:Nerve compression syndrome
2784:10.1038/s41591-021-01556-7
2674:10.1007/s00415-020-10124-x
1405:hospital in Paris in 1925.
1385:
1366:
1284:modifications, gait aids,
1254:activities of daily living
1222:negative inspiratory force
961:magnetic resonance imaging
915:antiganglioside antibodies
877:bound to a small group of
656:
631:/HHV-3) and the bacterium
233:intravenous immunoglobulin
5778:
5744:
5735:
5713:
5667:
5646:
5627:
5597:
5551:
5536:
5495:
5447:
5440:
5426:
5396:
5371:
5286:
5263:
5175:
5171:
5165:
5160:
5136:
5118:Pectoralis minor syndrome
5099:
5072:
5029:
5025:
5008:
4981:
4959:
4941:
4923:
4905:
4887:
4880:
4853:
4825:
4792:
4769:
4762:
4758:
4745:
4739:peripheral nervous system
4737:Diseases relating to the
4640:
4559:
3717:10.1016/j.ncl.2013.01.005
3601:Dantal J (October 2013).
3344:10.1038/nrneurol.2014.138
3332:Nature Reviews. Neurology
2718:European Medicines Agency
2162:10.1007/s10875-010-9407-4
1912:"Guillain-Barré syndrome"
1784:10.1038/nrneurol.2014.121
1771:Nature Reviews. Neurology
1290:Speech-language pathology
1202:intubation of the trachea
1049:Nerve conduction studies
824:electrical nerve impulses
717:European Medicines Agency
669:2009 flu pandemic vaccine
562:
549:pacemaker-based treatment
310:peripheral nervous system
268:
260:
252:
242:
224:
207:
199:
191:
181:
171:
159:
39:
31:
26:
5569:Henoch–Schönlein purpura
5384:Eosinophilic esophagitis
5144:Alcoholic polyneuropathy
5123:Thoracic outlet syndrome
3430:10.1136/jnnp-2013-304993
3282:Clinical Neurophysiology
3067:10.1016/j.it.2013.05.001
2764:Patone, Martina (2021).
2113:10.1136/jnnp-2012-302824
1278:rehabilitation physician
941:nerve conduction studies
557:reactivity of the pupils
513:blood clots in the lungs
461:neurological examination
353:nerve conduction studies
326:autonomic nervous system
215:nerve conduction studies
5685:Hashimoto's thyroiditis
5472:Guillain–Barré syndrome
5086:Guillain–Barré syndrome
5044:Dejerine–Sottas disease
4845:Cheiralgia paresthetica
4686:Guillain–Barré syndrome
4246:10.1136/bmj.1.5032.1384
4234:British Medical Journal
4185:British Medical Journal
2994:www.thecarlatreport.com
2960:10.1126/science.1066969
1576:www.merriam-webster.com
1262:occupational therapists
1235:
1128:Miller Fisher syndrome
996:cell count are elevated
965:spinal cord compression
665:1976 swine flu outbreak
659:1976 swine flu outbreak
415:swallowing difficulties
355:and examination of the
322:changes in the function
320:. Some are affected by
294:Guillain–Barré syndrome
27:Guillain–Barré syndrome
5786:Autoimmune adrenalitis
5188:Mononeuritis multiplex
5113:Brachial plexus injury
5019:Polyradiculoneuropathy
4943:superior gluteal nerve
4915:Tarsal tunnel syndrome
4897:Meralgia paraesthetica
4802:Ulnar nerve entrapment
4779:Carpal tunnel syndrome
2359:Nelson, K. E. (2012).
1448:Brighton Collaboration
1406:
1206:mechanical ventilation
1032:Miller Fisher syndrome
937:lumbar spinal puncture
886:-acetylneuraminic acid
828:neuromuscular junction
810:
629:varicella zoster virus
587:
477:level of consciousness
452:
421:. In 8%, the weakness
318:mechanical ventilation
264:7.5% of those affected
195:Rapid (hours to weeks)
5843:1976 health disasters
5203:Peripheral neuropathy
5078:demyelinating disease
4812:Ulnar tunnel syndrome
4494:"Coonhound Paralysis"
4320:10.1002/ana.410270707
4197:10.1136/bmj.2.4723.77
4057:10.1212/WNL.50.5.1451
3009:The Lancet. Neurology
2624:10.1093/brain/awaa240
2511:The Lancet. Neurology
2236:The Lancet. Neurology
2010:10.1056/NEJMra1114525
1827:The Lancet. Neurology
1487:(an inhibitor of the
1462:mycophenolate mofetil
1393:
1218:forced vital capacity
1069:No clear association
808:
634:Mycoplasma pneumoniae
575:
523:Autonomic dysfunction
450:
423:affects only the legs
5791:Autoimmune hepatitis
5770:Transplant rejection
5680:Giant cell arteritis
5610:Rheumatoid arthritis
5467:Goodpasture syndrome
5379:Autoimmune urticaria
4951:Trendelenburg's sign
4462:10.1292/jvms.20-0522
4296:10.1093/brain/aww127
4098:: 472–474, 486–488.
3969:10.1093/brain/awm004
3579:10.1212/WNL.61.6.736
3055:Trends in Immunology
2907:10.1136/jnnp.48.1.65
2662:Journal of Neurology
2574:10.1056/NEJMc2009191
2299:10.1099/jgv.0.000381
1877:Autoimmunity Reviews
1499:) may be effective.
1418:Jean Alexandre Barré
1046:Population affected
681:vaccine injury table
601:Campylobacter jejuni
583:Campylobacter jejuni
429:, painful tingling,
390:Jean Alexandre Barré
283:Jean Alexandre Barré
5848:Autoimmune diseases
5257:autoimmune diseases
4969:Piriformis syndrome
4855:long thoracic nerve
4498:VCA Animal Hospital
4314:. 27 Suppl: S21-4.
4312:Annals of Neurology
3164:10.1530/EJE-13-1020
2952:2001Sci...294.1021C
1455:Research directions
1258:physical therapists
1210:intensive care unit
1196:Respiratory failure
1009:Directly assessing
980:Cerebrospinal fluid
618:lipopolysaccharides
555:and changes in the
493:respiratory failure
487:Respiratory failure
357:cerebrospinal fluid
341:autoimmune disorder
300:) is a rapid-onset
213:Based on symptoms,
149:[ɡilɛ̃baʁe]
5700:Reactive arthritis
5690:Multiple sclerosis
5584:Reactive arthritis
5482:Pemphigus vulgaris
5462:Bullous pemphigoid
5363:Penicillin allergy
5299:Allergic urticaria
4784:Ape hand deformity
4641:External resources
4086:Landry JB (1859).
4013:10.1111/jns5.12051
3705:Neurologic Clinics
3387:10.1586/ern.11.182
3246:10.1111/jns5.12020
2815:UCL (2022-05-30).
2419:10.1093/cid/ciz135
2378:10.1093/aje/kws194
2212:10.1093/cid/ciu005
2156:(Suppl 1): S74-8.
1477:glatiramer acetate
1407:
1321:The European Union
1208:, generally on an
1186:liver inflammation
811:
625:Epstein–Barr virus
588:
580:-derived image of
469:hypo- or areflexia
453:
400:Signs and symptoms
361:certain antibodies
5830:
5829:
5826:
5825:
5731:
5730:
5623:
5622:
5532:
5531:
5528:
5527:
5520:Pernicious anemia
5515:Myasthenia gravis
5392:
5391:
5315:Atopic dermatitis
5304:Allergic rhinitis
5219:
5218:
5215:
5214:
5211:
5210:
5156:
5155:
5152:
5151:
5004:
5003:
5000:
4999:
4977:
4976:
4876:
4875:
4835:Radial neuropathy
4704:
4703:
3962:(Pt 9): 2245–57.
3620:10.1159/000354893
3471:(11): 2568–2579.
2778:(12): 2144–2153.
2617:(10): 3104–3120.
2568:(26): 2574–2576.
2371:(11): 1129–1132.
1922:(10045): 717–27.
1681:10.1159/000324710
1669:Neuroepidemiology
1540:Ferri FF (2016).
1451:plasma exchange.
1432:Edwin Bickerstaff
1151:
1150:
1025:Clinical subtypes
911:central tolerance
898:molecular mimicry
844:white blood cells
647:hepatitis E virus
509:severe infections
314:breathing muscles
291:
290:
209:Diagnostic method
21:Medical condition
5885:
5863:Myelin disorders
5813:Sjögren syndrome
5742:
5741:
5644:
5643:
5549:
5548:
5445:
5444:
5424:
5423:
5284:
5283:
5253:Hypersensitivity
5246:
5239:
5232:
5223:
5222:
5173:
5172:
5162:
5161:
5049:Refsum's disease
5027:
5026:
5010:
5009:
4933:Morton's neuroma
4885:
4884:
4767:
4766:
4760:
4759:
4747:
4746:
4731:
4724:
4717:
4708:
4707:
4557:
4556:
4530:
4502:
4501:
4490:
4484:
4483:
4473:
4441:
4435:
4434:
4398:
4379:
4378:
4346:
4340:
4339:
4307:
4301:
4300:
4298:
4289:(7): 2096–2100.
4274:
4268:
4267:
4257:
4240:(5032): 1384–7.
4225:
4219:
4218:
4208:
4176:
4170:
4169:
4141:
4135:
4134:
4110:
4104:
4103:
4083:
4077:
4076:
4040:
4034:
4033:
4015:
3991:
3982:
3981:
3971:
3947:
3941:
3940:
3938:
3937:
3923:
3917:
3916:
3914:
3913:
3899:
3893:
3892:
3890:
3889:
3875:
3869:
3868:
3851:(10): CD008505.
3844:
3838:
3837:
3809:
3796:
3795:
3785:
3745:
3739:
3738:
3728:
3696:
3690:
3689:
3679:
3654:(10): CD001446.
3639:
3633:
3632:
3622:
3598:
3592:
3591:
3581:
3557:
3548:
3547:
3537:
3520:(10): CD002063.
3505:
3499:
3498:
3488:
3456:
3450:
3449:
3413:
3407:
3406:
3370:
3364:
3363:
3327:
3314:
3313:
3277:
3266:
3265:
3229:
3212:
3211:
3183:
3177:
3176:
3166:
3142:
3136:
3135:
3109:
3085:
3079:
3078:
3050:
3041:
3040:
3004:
2998:
2997:
2986:
2980:
2979:
2946:(5544): 1021–4.
2935:
2929:
2928:
2918:
2886:
2880:
2879:
2861:
2837:
2831:
2830:
2828:
2827:
2812:
2806:
2805:
2795:
2761:
2755:
2754:
2752:
2751:
2736:
2730:
2729:
2727:
2725:
2710:
2704:
2703:
2693:
2668:(4): 1133–1170.
2653:
2647:
2646:
2636:
2626:
2602:
2596:
2595:
2585:
2553:
2547:
2546:
2536:
2526:
2502:
2496:
2490:
2489:
2485:
2483:
2482:
2467:
2461:
2460:
2458:
2456:
2451:. March 22, 2017
2446:
2438:
2432:
2431:
2421:
2397:
2391:
2390:
2380:
2356:
2350:
2349:
2321:
2312:
2311:
2301:
2283:
2274:
2268:
2267:
2231:
2225:
2224:
2214:
2205:(8): 1149–1155.
2190:
2184:
2183:
2173:
2141:
2126:
2125:
2115:
2091:
2068:
2067:
2031:
2022:
2021:
2004:(24): 2294–304.
1993:
1942:
1941:
1931:
1907:
1901:
1900:
1872:
1859:
1858:
1822:
1805:
1804:
1786:
1762:
1703:
1702:
1692:
1660:
1647:
1646:
1644:
1642:
1633:. June 1, 2016.
1623:
1586:
1585:
1583:
1582:
1568:
1562:
1561:
1537:
1428:C. Miller Fisher
1414:Georges Guillain
1395:Georges Guillain
1037:
1036:
1015:electromyography
984:lumbar vertebrae
840:nodes of Ranvier
749:
545:heart beat stops
386:Georges Guillain
278:Georges Guillain
151:
146:
142:
141:
138:
137:
134:
131:
128:
125:
121:
120:
117:
114:
111:
108:
105:
98:
90:
89:
86:
85:
82:
79:
76:
72:
71:
68:
65:
62:
59:
52:
24:
23:
5893:
5892:
5888:
5887:
5886:
5884:
5883:
5882:
5833:
5832:
5831:
5822:
5774:
5737:
5727:
5709:
5705:Type 1 diabetes
5675:Coeliac disease
5663:
5635:
5619:
5593:
5559:Arthus reaction
5540:
5524:
5510:Graves' disease
5491:
5487:Rheumatic fever
5436:
5404:
5388:
5367:
5294:Allergic asthma
5275:
5259:
5250:
5220:
5207:
5167:
5148:
5132:
5095:
5068:
5021:
4996:
4973:
4955:
4937:
4919:
4901:
4872:
4849:
4821:
4788:
4754:
4741:
4735:
4705:
4700:
4699:
4636:
4635:
4568:
4537:
4527:
4511:
4509:Further reading
4506:
4505:
4492:
4491:
4487:
4442:
4438:
4399:
4382:
4347:
4343:
4308:
4304:
4275:
4271:
4226:
4222:
4191:(4723): 77–81.
4177:
4173:
4142:
4138:
4111:
4107:
4084:
4080:
4041:
4037:
3992:
3985:
3948:
3944:
3935:
3933:
3925:
3924:
3920:
3911:
3909:
3901:
3900:
3896:
3887:
3885:
3877:
3876:
3872:
3845:
3841:
3810:
3799:
3760:(4): CD009950.
3746:
3742:
3697:
3693:
3640:
3636:
3599:
3595:
3558:
3551:
3506:
3502:
3457:
3453:
3414:
3410:
3371:
3367:
3328:
3317:
3278:
3269:
3230:
3215:
3184:
3180:
3143:
3139:
3086:
3082:
3051:
3044:
3005:
3001:
2988:
2987:
2983:
2936:
2932:
2887:
2883:
2852:(10): 924–928.
2838:
2834:
2825:
2823:
2813:
2809:
2771:Nature Medicine
2762:
2758:
2749:
2747:
2738:
2737:
2733:
2723:
2721:
2712:
2711:
2707:
2654:
2650:
2603:
2599:
2554:
2550:
2503:
2499:
2487:
2480:
2478:
2469:
2468:
2464:
2454:
2452:
2444:
2440:
2439:
2435:
2398:
2394:
2357:
2353:
2322:
2315:
2281:
2275:
2271:
2232:
2228:
2191:
2187:
2142:
2129:
2092:
2071:
2032:
2025:
1994:
1945:
1908:
1904:
1883:(4–5): 525–30.
1873:
1862:
1823:
1808:
1763:
1706:
1661:
1650:
1640:
1638:
1625:
1624:
1589:
1580:
1578:
1570:
1569:
1565:
1554:
1538:
1521:
1516:
1470:interferon beta
1457:
1388:
1371:
1365:
1329:
1250:
1242:pain medication
1238:
1229:
1198:
1190:Glucocorticoids
1175:
1170:
1159:Babinski's sign
1027:
1007:
1005:Neurophysiology
977:
959:In many cases,
932:
822:) that carries
803:
802:
801:
798:
797:
796:
791:
786:
781:
778:
774:
769:
764:
759:
754:
740:
738:Pathophysiology
729:
701:
693:GlaxoSmithKline
661:
655:
606:cytomegalovirus
592:gastroenteritis
570:
568:Infection onset
565:
525:
489:
465:tendon reflexes
402:
302:muscle weakness
287:
229:Supportive care
219:lumbar puncture
155:
144:
143:
122:
102:
93:
92:
91:
73:
56:
47:
46:
22:
17:
12:
11:
5:
5891:
5881:
5880:
5875:
5870:
5865:
5860:
5858:Medical triads
5855:
5850:
5845:
5828:
5827:
5824:
5823:
5821:
5820:
5815:
5810:
5809:
5808:
5803:
5793:
5788:
5782:
5780:
5776:
5775:
5773:
5772:
5767:
5761:
5760:
5759:
5748:
5746:
5739:
5733:
5732:
5729:
5728:
5726:
5725:
5719:
5717:
5711:
5710:
5708:
5707:
5702:
5697:
5692:
5687:
5682:
5677:
5671:
5669:
5665:
5664:
5662:
5661:
5656:
5650:
5648:
5641:
5625:
5624:
5621:
5620:
5618:
5617:
5612:
5607:
5601:
5599:
5595:
5594:
5592:
5591:
5589:Serum sickness
5586:
5581:
5576:
5571:
5566:
5561:
5555:
5553:
5546:
5543:Immune complex
5534:
5533:
5530:
5529:
5526:
5525:
5523:
5522:
5517:
5512:
5506:
5504:
5493:
5492:
5490:
5489:
5484:
5479:
5474:
5469:
5464:
5459:
5453:
5451:
5442:
5438:
5437:
5435:
5430:
5428:
5421:
5420:
5419:
5418:
5417:
5412:
5394:
5393:
5390:
5389:
5387:
5386:
5381:
5375:
5373:
5369:
5368:
5366:
5365:
5360:
5359:
5358:
5353:
5348:
5343:
5338:
5333:
5328:
5317:
5312:
5307:
5301:
5296:
5290:
5288:
5281:
5261:
5260:
5249:
5248:
5241:
5234:
5226:
5217:
5216:
5213:
5212:
5209:
5208:
5206:
5205:
5200:
5195:
5190:
5185:
5179:
5177:
5169:
5168:
5158:
5157:
5154:
5153:
5150:
5149:
5147:
5146:
5140:
5138:
5134:
5133:
5131:
5130:
5125:
5120:
5115:
5109:
5107:
5097:
5096:
5094:
5093:
5088:
5082:
5080:
5070:
5069:
5067:
5066:
5061:
5056:
5051:
5046:
5041:
5035:
5033:
5023:
5022:
5015:Polyneuropathy
5006:
5005:
5002:
5001:
4998:
4997:
4995:
4994:
4987:
4985:
4983:Cranial nerves
4979:
4978:
4975:
4974:
4972:
4971:
4965:
4963:
4957:
4956:
4954:
4953:
4947:
4945:
4939:
4938:
4936:
4935:
4929:
4927:
4921:
4920:
4918:
4917:
4911:
4909:
4903:
4902:
4900:
4899:
4893:
4891:
4882:
4878:
4877:
4874:
4873:
4871:
4870:
4868:Backpack palsy
4865:
4863:Winged scapula
4859:
4857:
4851:
4850:
4848:
4847:
4842:
4837:
4831:
4829:
4823:
4822:
4820:
4819:
4814:
4809:
4807:Froment's sign
4804:
4798:
4796:
4790:
4789:
4787:
4786:
4781:
4775:
4773:
4764:
4756:
4755:
4752:Mononeuropathy
4743:
4742:
4734:
4733:
4726:
4719:
4711:
4702:
4701:
4698:
4697:
4688:
4677:
4657:
4645:
4644:
4642:
4638:
4637:
4634:
4633:
4622:
4611:
4600:
4585:
4569:
4564:
4563:
4561:
4560:Classification
4554:
4553:
4548:
4543:
4536:
4535:External links
4533:
4532:
4531:
4525:
4510:
4507:
4504:
4503:
4485:
4456:(3): 465–468.
4436:
4380:
4361:(3): 599–612.
4341:
4302:
4269:
4220:
4171:
4136:
4105:
4078:
4035:
3983:
3942:
3918:
3894:
3870:
3839:
3797:
3740:
3711:(2): 491–510.
3691:
3634:
3593:
3549:
3500:
3451:
3424:(11): 1206–7.
3408:
3365:
3315:
3288:(8): 1487–95.
3267:
3213:
3194:(17): 1130–6.
3178:
3137:
3080:
3042:
3015:(12): 1180–8.
2999:
2981:
2930:
2881:
2832:
2807:
2756:
2731:
2720:. 22 July 2021
2705:
2648:
2597:
2548:
2517:(9): 767–783.
2497:
2462:
2433:
2412:(4): 726–731.
2392:
2351:
2313:
2292:(2): 269–273.
2269:
2242:(9): 906–919.
2226:
2185:
2127:
2069:
2023:
1943:
1902:
1860:
1833:(10): 939–50.
1806:
1704:
1648:
1587:
1563:
1552:
1518:
1517:
1515:
1512:
1456:
1453:
1434:described the
1387:
1384:
1364:
1361:
1328:
1325:
1313:United Kingdom
1249:
1248:Rehabilitation
1246:
1237:
1234:
1227:
1220:(FVC) and the
1197:
1194:
1178:Plasmapheresis
1174:
1171:
1169:
1166:
1149:
1148:
1145:
1138:
1135:
1129:
1125:
1124:
1121:
1118:
1115:
1112:
1108:
1107:
1104:
1101:
1098:
1095:
1091:
1090:
1087:
1084:
1081:
1078:
1071:
1070:
1067:
1064:
1061:
1058:
1054:
1053:
1050:
1047:
1044:
1041:
1026:
1023:
1006:
1003:
976:
973:
931:
928:
860:IgG antibodies
799:
792:
787:
782:
775:
770:
765:
760:
755:
750:
744:
743:
742:
741:
739:
736:
728:
725:
700:
697:
687:Shingrix, the
685:Zoster vaccine
654:
651:
569:
566:
564:
561:
537:blood pressure
524:
521:
501:carbon dioxide
488:
485:
417:and sometimes
407:cranial nerves
401:
398:
376:plasmapheresis
365:polyneuropathy
334:blood pressure
304:caused by the
289:
288:
286:
285:
280:
274:
272:
266:
265:
262:
258:
257:
254:
250:
249:
246:
240:
239:
237:plasmapheresis
226:
222:
221:
211:
205:
204:
201:
197:
196:
193:
189:
188:
185:
179:
178:
175:
169:
168:
163:
157:
156:
154:
153:
43:
41:
37:
36:
33:
29:
28:
20:
15:
9:
6:
4:
3:
2:
5890:
5879:
5876:
5874:
5871:
5869:
5866:
5864:
5861:
5859:
5856:
5854:
5851:
5849:
5846:
5844:
5841:
5840:
5838:
5819:
5816:
5814:
5811:
5807:
5804:
5802:
5799:
5798:
5797:
5794:
5792:
5789:
5787:
5784:
5783:
5781:
5777:
5771:
5768:
5765:
5764:Latex allergy
5762:
5758:
5755:
5754:
5753:
5750:
5749:
5747:
5743:
5740:
5734:
5724:
5721:
5720:
5718:
5716:
5712:
5706:
5703:
5701:
5698:
5696:
5693:
5691:
5688:
5686:
5683:
5681:
5678:
5676:
5673:
5672:
5670:
5666:
5660:
5657:
5655:
5652:
5651:
5649:
5645:
5642:
5639:
5634:
5633:cell-mediated
5630:
5626:
5616:
5613:
5611:
5608:
5606:
5603:
5602:
5600:
5596:
5590:
5587:
5585:
5582:
5580:
5577:
5575:
5572:
5570:
5567:
5565:
5564:Farmer's lung
5562:
5560:
5557:
5556:
5554:
5550:
5547:
5544:
5539:
5535:
5521:
5518:
5516:
5513:
5511:
5508:
5507:
5505:
5503:
5499:
5494:
5488:
5485:
5483:
5480:
5478:
5475:
5473:
5470:
5468:
5465:
5463:
5460:
5458:
5455:
5454:
5452:
5450:
5446:
5443:
5439:
5434:
5431:
5429:
5425:
5422:
5416:
5413:
5411:
5408:
5407:
5406:
5405:
5403:
5399:
5395:
5385:
5382:
5380:
5377:
5376:
5374:
5370:
5364:
5361:
5357:
5354:
5352:
5349:
5347:
5344:
5342:
5339:
5337:
5334:
5332:
5329:
5327:
5323:
5322:
5321:
5318:
5316:
5313:
5311:
5308:
5305:
5302:
5300:
5297:
5295:
5292:
5291:
5289:
5285:
5282:
5279:
5274:
5270:
5266:
5262:
5258:
5254:
5247:
5242:
5240:
5235:
5233:
5228:
5227:
5224:
5204:
5201:
5199:
5196:
5194:
5191:
5189:
5186:
5184:
5181:
5180:
5178:
5174:
5170:
5163:
5159:
5145:
5142:
5141:
5139:
5135:
5129:
5126:
5124:
5121:
5119:
5116:
5114:
5111:
5110:
5108:
5106:
5102:
5101:Radiculopathy
5098:
5092:
5089:
5087:
5084:
5083:
5081:
5079:
5075:
5071:
5065:
5062:
5060:
5057:
5055:
5052:
5050:
5047:
5045:
5042:
5040:
5037:
5036:
5034:
5032:
5028:
5024:
5020:
5016:
5011:
5007:
4993:
4989:
4988:
4986:
4984:
4980:
4970:
4967:
4966:
4964:
4962:
4961:sciatic nerve
4958:
4952:
4949:
4948:
4946:
4944:
4940:
4934:
4931:
4930:
4928:
4926:
4925:plantar nerve
4922:
4916:
4913:
4912:
4910:
4908:
4904:
4898:
4895:
4894:
4892:
4890:
4886:
4883:
4879:
4869:
4866:
4864:
4861:
4860:
4858:
4856:
4852:
4846:
4843:
4841:
4838:
4836:
4833:
4832:
4830:
4828:
4824:
4818:
4815:
4813:
4810:
4808:
4805:
4803:
4800:
4799:
4797:
4795:
4791:
4785:
4782:
4780:
4777:
4776:
4774:
4772:
4768:
4765:
4761:
4757:
4753:
4748:
4744:
4740:
4732:
4727:
4725:
4720:
4718:
4713:
4712:
4709:
4696:
4692:
4689:
4687:
4683:
4682:
4678:
4676:
4673:
4670:
4667:
4663:
4662:
4658:
4656:
4652:
4651:
4647:
4646:
4643:
4639:
4632:
4628:
4627:
4623:
4621:
4617:
4616:
4612:
4610:
4606:
4605:
4601:
4599:
4595:
4594:
4590:
4586:
4584:
4580:
4579:
4575:
4571:
4570:
4567:
4562:
4558:
4552:
4549:
4547:
4544:
4542:
4539:
4538:
4528:
4526:9781932603569
4522:
4518:
4513:
4512:
4499:
4495:
4489:
4481:
4477:
4472:
4467:
4463:
4459:
4455:
4451:
4447:
4440:
4432:
4428:
4424:
4420:
4416:
4412:
4409:(1): 105–20.
4408:
4404:
4397:
4395:
4393:
4391:
4389:
4387:
4385:
4376:
4372:
4368:
4364:
4360:
4356:
4352:
4345:
4337:
4333:
4329:
4325:
4321:
4317:
4313:
4306:
4297:
4292:
4288:
4284:
4280:
4273:
4265:
4261:
4256:
4251:
4247:
4243:
4239:
4235:
4231:
4224:
4216:
4212:
4207:
4202:
4198:
4194:
4190:
4186:
4182:
4175:
4167:
4163:
4159:
4155:
4151:
4147:
4140:
4132:
4128:
4124:
4121:(in French).
4120:
4116:
4109:
4101:
4097:
4093:
4089:
4082:
4074:
4070:
4066:
4062:
4058:
4054:
4051:(5): 1451–5.
4050:
4046:
4039:
4031:
4027:
4023:
4019:
4014:
4009:
4005:
4001:
3997:
3990:
3988:
3979:
3975:
3970:
3965:
3961:
3957:
3953:
3946:
3932:
3928:
3922:
3908:
3904:
3898:
3884:
3880:
3874:
3866:
3862:
3858:
3854:
3850:
3843:
3835:
3831:
3827:
3824:(3): 507–22.
3823:
3819:
3815:
3808:
3806:
3804:
3802:
3793:
3789:
3784:
3779:
3775:
3771:
3767:
3763:
3759:
3755:
3751:
3744:
3736:
3732:
3727:
3722:
3718:
3714:
3710:
3706:
3702:
3695:
3687:
3683:
3678:
3673:
3669:
3665:
3661:
3657:
3653:
3649:
3645:
3638:
3630:
3626:
3621:
3616:
3613:(4): 275–84.
3612:
3608:
3604:
3597:
3589:
3585:
3580:
3575:
3572:(6): 736–40.
3571:
3567:
3563:
3556:
3554:
3545:
3541:
3536:
3531:
3527:
3523:
3519:
3515:
3511:
3504:
3496:
3492:
3487:
3482:
3478:
3474:
3470:
3466:
3462:
3455:
3447:
3443:
3439:
3435:
3431:
3427:
3423:
3419:
3412:
3404:
3400:
3396:
3392:
3388:
3384:
3380:
3376:
3369:
3361:
3357:
3353:
3349:
3345:
3341:
3338:(9): 537–44.
3337:
3333:
3326:
3324:
3322:
3320:
3311:
3307:
3303:
3299:
3295:
3291:
3287:
3283:
3276:
3274:
3272:
3263:
3259:
3255:
3251:
3247:
3243:
3240:(2): 99–112.
3239:
3235:
3228:
3226:
3224:
3222:
3220:
3218:
3209:
3205:
3201:
3197:
3193:
3189:
3182:
3174:
3170:
3165:
3160:
3156:
3152:
3148:
3141:
3133:
3129:
3125:
3121:
3117:
3113:
3108:
3103:
3099:
3095:
3091:
3084:
3076:
3072:
3068:
3064:
3060:
3056:
3049:
3047:
3038:
3034:
3030:
3026:
3022:
3018:
3014:
3010:
3003:
2995:
2991:
2985:
2977:
2973:
2969:
2965:
2961:
2957:
2953:
2949:
2945:
2941:
2934:
2926:
2922:
2917:
2912:
2908:
2904:
2900:
2896:
2892:
2885:
2877:
2873:
2869:
2865:
2860:
2855:
2851:
2847:
2843:
2836:
2822:
2818:
2811:
2803:
2799:
2794:
2789:
2785:
2781:
2777:
2773:
2772:
2767:
2760:
2745:
2741:
2735:
2719:
2715:
2709:
2701:
2697:
2692:
2687:
2683:
2679:
2675:
2671:
2667:
2663:
2659:
2652:
2644:
2640:
2635:
2630:
2625:
2620:
2616:
2612:
2608:
2601:
2593:
2589:
2584:
2579:
2575:
2571:
2567:
2563:
2559:
2552:
2544:
2540:
2535:
2530:
2525:
2520:
2516:
2512:
2508:
2501:
2494:
2493:public domain
2476:
2472:
2466:
2450:
2443:
2437:
2429:
2425:
2420:
2415:
2411:
2407:
2403:
2396:
2388:
2384:
2379:
2374:
2370:
2366:
2362:
2355:
2347:
2343:
2339:
2335:
2332:(9): 643–51.
2331:
2327:
2320:
2318:
2309:
2305:
2300:
2295:
2291:
2287:
2280:
2273:
2265:
2261:
2257:
2253:
2249:
2245:
2241:
2237:
2230:
2222:
2218:
2213:
2208:
2204:
2200:
2196:
2189:
2181:
2177:
2172:
2167:
2163:
2159:
2155:
2151:
2147:
2140:
2138:
2136:
2134:
2132:
2123:
2119:
2114:
2109:
2106:(5): 576–83.
2105:
2101:
2097:
2090:
2088:
2086:
2084:
2082:
2080:
2078:
2076:
2074:
2065:
2061:
2057:
2053:
2049:
2045:
2042:(6): 689–93.
2041:
2037:
2030:
2028:
2019:
2015:
2011:
2007:
2003:
1999:
1992:
1990:
1988:
1986:
1984:
1982:
1980:
1978:
1976:
1974:
1972:
1970:
1968:
1966:
1964:
1962:
1960:
1958:
1956:
1954:
1952:
1950:
1948:
1939:
1935:
1930:
1925:
1921:
1917:
1913:
1906:
1898:
1894:
1890:
1886:
1882:
1878:
1871:
1869:
1867:
1865:
1856:
1852:
1848:
1844:
1840:
1836:
1832:
1828:
1821:
1819:
1817:
1815:
1813:
1811:
1802:
1798:
1794:
1790:
1785:
1780:
1777:(8): 469–82.
1776:
1772:
1768:
1761:
1759:
1757:
1755:
1753:
1751:
1749:
1747:
1745:
1743:
1741:
1739:
1737:
1735:
1733:
1731:
1729:
1727:
1725:
1723:
1721:
1719:
1717:
1715:
1713:
1711:
1709:
1700:
1696:
1691:
1686:
1682:
1678:
1675:(2): 123–33.
1674:
1670:
1666:
1659:
1657:
1655:
1653:
1636:
1632:
1628:
1622:
1620:
1618:
1616:
1614:
1612:
1610:
1608:
1606:
1604:
1602:
1600:
1598:
1596:
1594:
1592:
1577:
1573:
1567:
1559:
1555:
1553:9780323448383
1549:
1545:
1544:
1536:
1534:
1532:
1530:
1528:
1526:
1524:
1519:
1511:
1509:
1505:
1500:
1498:
1494:
1490:
1486:
1482:
1478:
1473:
1471:
1467:
1463:
1452:
1449:
1445:
1440:
1437:
1433:
1429:
1425:
1423:
1419:
1415:
1411:
1404:
1400:
1396:
1392:
1383:
1379:
1377:
1376:relative risk
1370:
1360:
1358:
1354:
1350:
1345:
1341:
1339:
1333:
1324:
1322:
1318:
1314:
1310:
1306:
1301:
1299:
1295:
1291:
1287:
1281:
1279:
1275:
1271:
1267:
1266:psychologists
1263:
1259:
1255:
1245:
1243:
1233:
1231:
1223:
1219:
1215:
1211:
1207:
1203:
1193:
1191:
1187:
1183:
1179:
1173:Immunotherapy
1165:
1162:
1160:
1156:
1146:
1143:
1139:
1136:
1133:
1130:
1127:
1126:
1122:
1119:
1116:
1113:
1110:
1109:
1105:
1102:
1099:
1096:
1093:
1092:
1088:
1085:
1082:
1079:
1076:
1073:
1072:
1068:
1065:
1062:
1059:
1056:
1055:
1051:
1048:
1045:
1042:
1039:
1038:
1035:
1033:
1022:
1018:
1016:
1012:
1002:
999:
997:
993:
992:poliomyelitis
989:
985:
981:
972:
970:
966:
962:
957:
955:
951:
947:
942:
938:
927:
923:
920:
916:
912:
907:
903:
902:Campylobacter
899:
895:
891:
887:
885:
880:
876:
872:
867:
865:
861:
857:
853:
849:
848:T lymphocytes
845:
841:
837:
834:that contain
833:
832:Schwann cells
829:
825:
821:
817:
807:
795:
794:Myelin sheath
790:
785:
784:Axon terminal
780:
773:
768:
763:
758:
753:
748:
735:
733:
724:
721:
718:
714:
710:
706:
696:
694:
690:
686:
682:
677:
674:
670:
666:
660:
653:Vaccine onset
650:
648:
644:
640:
636:
635:
630:
626:
621:
619:
615:
614:Campylobacter
611:
610:Campylobacter
607:
603:
602:
597:
593:
585:
584:
579:
574:
560:
558:
554:
550:
547:and requires
546:
542:
538:
534:
530:
520:
518:
514:
510:
506:
502:
498:
494:
484:
482:
478:
474:
470:
466:
462:
457:
449:
445:
443:
439:
434:
432:
428:
424:
420:
416:
412:
408:
397:
395:
391:
387:
384:
379:
377:
373:
368:
366:
362:
358:
354:
350:
346:
342:
337:
335:
331:
327:
323:
319:
315:
311:
308:damaging the
307:
306:immune system
303:
299:
295:
284:
281:
279:
276:
275:
273:
271:
267:
263:
259:
255:
251:
247:
245:
241:
238:
234:
230:
227:
223:
220:
216:
212:
210:
206:
202:
198:
194:
190:
186:
184:
183:Complications
180:
176:
174:
170:
167:
164:
162:
158:
150:
140:
96:
88:
50:
45:
44:
42:
40:Pronunciation
38:
34:
30:
25:
19:
5659:Mantoux test
5471:
5320:Food allergy
5128:Phantom limb
5085:
4907:tibial nerve
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