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meaning 'mark.' Thus, idiotype describes the distinctive sequence and region that makes any immunoglobulin/TCR unique from others of the same type which is its variable region.
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The term "idiotype" is sometimes used to describe the collection of multiple idiotopes, and therefore overall antigen binding capacity, possessed by an antibody.
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in 1984 largely for being the father of immune network theory. He defined idiotype as the set of epitopes on the V region of an antibody molecule, where
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sequences. They define the surface and properties of the variable region, determining the antigen specificity and therefore the idio
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The idiotype is based upon the variable region (labeled VL and VH in the diagram.)
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P-nucleotides (palindromic nucleotides at sites of single-strand breaks)
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The word "idiotype" became influential in immunology when
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of the molecule. Immunoglobulins or TCRs with a shared
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means an antigenic determinant. He also defined the "
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binding specificity and therefore structure of their
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43:but its sources remain unclear because it lacks
171:The word idiotype comes from two Greek roots,
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102:is a shared characteristic between a group of
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175:meaning 'private, distinctive, peculiar' and
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243:at the U.S. National Library of Medicine
74:Learn how and when to remove this message
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264:Southern Illinois University Carbondale
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146:. Antibody idiotype is determined by:
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195:Nobel Prize in Physiology or Medicine
255:Medical University of South Carolina
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128:complementarity-determining regions
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110:(TCR) molecules based upon the
618:Immunoglobulin class switching
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447:Polyclonal B cell response
207:symmetrical network theory
126:(immunoglobulins) contain
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245:Medical Subject Headings
241:Immunoglobulin+idiotypes
193:. Jerne was awarded the
29:This article includes a
58:more precise citations.
561:Tolerance in pregnancy
303:adaptive immune system
162:Somatic hypermutations
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596:Somatic hypermutation
430:Polyclonal antibodies
425:Monoclonal antibodies
229:Immune network theory
219:Allotype (immunology)
191:immune network theory
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613:Junctional diversity
381:Antigen presentation
224:Isotype (immunology)
153:Junctional diversity
608:V(D)J recombination
591:Affinity maturation
343:Antigenic variation
167:Etymology and usage
130:(CDRs) with unique
150:Gene rearrangement
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31:list of references
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385:professional APCs
142:are the same idio
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601:Clonal selection
573:Immune privilege
568:Immunodeficiency
523:Cross-reactivity
513:Hypersensitivity
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518:Inflammation
503:Alloimmunity
498:Autoimmunity
483:Immunity vs.
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435:Autoantibody
333:Superantigen
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64:January 2014
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50:Please help
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641:Lymphocytes
300:Lymphocytic
187:Niels Jerne
122:(TCRs) and
56:introducing
682:Substances
546:Peripheral
534:Inaction:
413:Antibodies
394:Macrophage
307:complement
132:amino acid
96:immunology
699:Cytolysin
689:Cytokines
536:Tolerance
485:tolerance
404:Immunogen
714:Category
649:Cellular
493:Immunity
491:Action:
474:Paratope
462:Idiotype
452:Allotype
420:Antibody
374:Mimotope
338:Allergen
321:Antigens
314:Lymphoid
260:Overview
251:Overview
213:See also
203:paratope
140:idiotope
100:idiotype
694:Opsonin
673:NK cell
661:Humoral
541:Central
508:Allergy
457:Isotype
357:Epitope
328:Antigen
199:epitope
124:B cells
120:T cells
112:antigen
52:improve
666:B cell
654:T cell
399:B cell
362:Linear
350:Hapten
247:(MeSH)
177:typos
98:, an
37:, or
305:and
173:idio
144:type
136:tope
627:HLA
623:MHC
262:at
253:at
106:or
94:In
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383:/
292:e
285:t
278:v
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