611:
588:
42:
3300:
1395:
1355:
842:
The parent compound of pomalidomide, thalidomide, was originally discovered to inhibit angiogenesis in 1994. Based upon this discovery, thalidomide was taken into clinical trials for cancer, leading to its ultimate FDA approval for multiple myeloma. Structure-activity studies revealed that amino
823:; and in combination with dexamethasone is indicated in the treatment of adults with relapsed and refractory multiple myeloma who have received at least two prior treatment regimens, including both lenalidomide and bortezomib, and have demonstrated disease progression on the last therapy.
843:
substituted thalidomide had improved antitumor activity, which was due to its ability to directly inhibit both the tumor cell and vascular compartments of myeloma cancers. This dual activity of pomalidomide makes it more efficacious than thalidomide
1011:
1672:
Streetly MJ, Gyertson K, Daniel Y, Zeldis JB, Kazmi M, Schey SA (April 2008). "Alternate day pomalidomide retains anti-myeloma effect with reduced adverse events and evidence of in vivo immunomodulation".
1041:
1380:
859:
Pomalidomide directly inhibits angiogenesis and myeloma cell growth. This dual effect is central to its activity in myeloma, rather than other pathways such as TNF alpha inhibition, since potent
826:
In the United States, pomalidomide is indicated, in combination with dexamethasone, for people with multiple myeloma who have received at least two prior therapies including lenalidomide and a
1604:
Lentzsch S, Rogers MS, LeBlanc R, Birsner AE, Shah JH, Treston AM, et al. (April 2002). "S-3-Amino-phthalimido-glutarimide inhibits angiogenesis and growth of B-cell neoplasias in mice".
1777:"Pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone alone for patients with relapsed and refractory multiple myeloma (MM-003): a randomised, open-label, phase 3 trial"
1003:
1240:
228:
1450:
830:
and have demonstrated disease progression on or within 60 days of completion of the last therapy; and is indicated for people with AIDS-related Kaposi sarcoma after failure of
1420:
1164:
1210:
1307:
1075:
1070:[Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).
680:
1033:
1540:
1372:
183:
1277:
748:
241:
115:
3325:
1825:
1569:
D'Amato RJ, Lentzsch S, Anderson KC, Rogers MS (December 2001). "Mechanism of action of thalidomide and 3-aminothalidomide in multiple myeloma".
795:
Pomalidomide was approved for medical use in the United States in
February 2013, and in the European Union in August 2013. It is available as a
1233:
1340:
1223:
Text was copied from this source which is copyright
European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
64:
3167:
3025:
1868:
704:
3177:
2863:
2304:
1753:
1442:
2784:
1724:
891:
have been reported for pomalidomide. These changes may contribute to pomalidomide's anti-angiogenic and anti-myeloma activities.
1412:
1156:
1127:
3330:
981:
1199:
1299:
831:
1067:
755:
132:
1063:
2727:
2097:
724:
1861:
1544:
819:
in the treatment of adults with multiple myeloma who have received at least one prior treatment regimen including
3136:
1265:
872:
385:
213:
96:
1749:
Pomalidomide
Therapy in Anemic Patients with Myelofibrosis: Results from a Phase-2 Randomized Multicenter Study
456:
1068:"RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial"
1933:
1271:
1071:
732:
InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
606:
507:
1097:
3340:
2042:
1854:
567:
556:
3290:
1912:
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1204:
939:
110:
583:
3320:
2970:
1332:
2965:
169:
54:
17:
1234:"Imnovid 1 mg Hard Capsules. Summary of Product Characteristics. 5.2 Pharmacokinetic properties"
2770:
2196:
1877:
777:
315:
3350:
3345:
3335:
2957:
1747:
691:
447:
1776:
496:
1485:
827:
516:
411:
354:
8:
2178:
1775:
Miguel JS, Weisel K, Moreau P, Lacy M, Song K, Delforge M, et al. (September 2013).
1004:"Pomalidomide Medicianz/ Pomalimed/ Pomalidomide Medsurge (Medicianz Healthcare Pty Ltd)"
910:
610:
587:
402:
176:
1489:
3127:
2228:
1817:
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1511:
1493:
943:
876:
781:
623:
436:
297:
196:
1034:"Prescription medicines: registration of new chemical entities in Australia, 2014"
3304:
3227:
3112:
325:
305:
3117:
2985:
2633:
2467:
2446:
2442:
2438:
2066:
1903:
1478:
Proceedings of the
National Academy of Sciences of the United States of America
884:
868:
789:
3314:
3267:
3197:
3107:
3014:
2800:
2500:
2422:
2374:
2354:
2212:
2128:
1979:
1945:
1399:
1359:
953:
932:
888:
880:
860:
812:
599:
33:
1717:"Promising Results From 2 Trials Highlighting Pomalidomide Presented At ASH"
3277:
3237:
3222:
3217:
2933:
2883:
2878:
2858:
2738:
2733:
2596:
2581:
2529:
2505:
2452:
2329:
2319:
2138:
2050:
2008:
1961:
1918:
1885:
1813:
1694:
1658:
1617:
1590:
1498:
820:
191:
41:
1525:
3272:
3212:
3202:
3192:
3092:
3082:
3072:
3067:
3032:
2943:
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2913:
2903:
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2806:
2776:
2762:
2757:
2743:
2686:
2644:
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2606:
2586:
2539:
2515:
2473:
2457:
2428:
2412:
2380:
2364:
2359:
2334:
2284:
2274:
2269:
2264:
2253:
2243:
2148:
2060:
2018:
2003:
1997:
1993:
1940:
82:
1120:"Imnovid 1 mg hard capsules - Summary of Product Characteristics (SmPC)"
476:
3262:
3257:
3242:
3182:
3172:
3157:
3152:
3147:
3097:
3087:
3077:
3042:
3020:
3006:
2918:
2908:
2898:
2888:
2873:
2816:
2811:
2790:
2705:
2700:
2658:
2652:
2553:
2510:
2406:
2396:
2349:
2339:
2314:
2309:
2299:
2294:
2289:
2279:
2238:
2223:
2218:
2202:
2143:
2123:
2072:
2032:
2013:
1955:
1804:
1507:
808:
656:
487:
1876:
3252:
3247:
3232:
3207:
3162:
3142:
3102:
3037:
3001:
2923:
2719:
2672:
2601:
2567:
2534:
2344:
2324:
2233:
2133:
1973:
1266:"Drug Approval Package: Pomalyst (pomalidomide) Capsules NDA #204026"
898:
816:
422:
367:
68:
1373:"FDA grants accelerated approval to pomalidomide for Kaposi sarcoma"
3187:
3062:
2751:
2259:
2169:
2105:
2027:
895:
864:
536:
467:
127:
679:
2680:
1720:
1568:
1398:
This article incorporates text from this source, which is in the
1358:
This article incorporates text from this source, which is in the
948:
342:
114:
2995:
2826:
1541:"From Thalidomide to Pomalyst: Better Living Through Chemistry"
1471:
834:(HAART) or in people with Kaposi sarcoma who are HIV-negative.
547:
346:
338:
334:
2694:
2547:
917:
670:
330:
1671:
1603:
572:
2666:
2614:
2575:
2561:
2115:
1989:
1413:"FDA approves pomalidomide for AIDS-related Kaposi sarcoma"
785:
527:
1472:
D'Amato RJ, Loughnan MS, Flynn E, Folkman J (April 1994).
2523:
1752:. 50th ASH Annual Meeting and Exposition. San Francisco.
807:
In the
European Union, pomalidomide, in combination with
1630:
1774:
393:
4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
3288:
928:
Phase I trial results showed tolerable side effects.
871:
do not inhibit myeloma cell growth or angiogenesis.
1631:Asatsuma-Okumura T, Ito T, Handa H (October 2019).
1327:
1325:
455:
966:
938:Phase III results showed significant extension of
931:Phase II clinical trials for multiple myeloma and
3312:
1322:
435:
1564:
1562:
410:
1633:"Molecular mechanisms of cereblon-based drugs"
1194:
1192:
1190:
1188:
1186:
1184:
1182:
974:"Pomalidomide (Pomalyst) Use During Pregnancy"
952:= 0.0002) in patients taking pomalidomide and
1862:
1474:"Thalidomide is an inhibitor of angiogenesis"
1151:
1149:
1147:
1145:
1559:
131:
1179:
712:C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)N
1869:
1855:
1142:
894:Like thalidomide, pomalidomide works as a
609:
586:
495:
1803:
1648:
1515:
1497:
837:
515:
3326:Drugs developed by Bristol Myers Squibb
1745:
582:
475:
341:-mediated; some minor contributions by
87:
14:
3313:
1756:from the original on 20 September 2018
1727:from the original on 20 September 2018
1538:
1310:from the original on 26 September 2021
1062:
1038:Therapeutic Goods Administration (TGA)
1008:Therapeutic Goods Administration (TGA)
854:
600:
284:
259:
105:
1850:
555:
272:
122:
73:
1831:from the original on 20 October 2021
1343:from the original on 15 January 2023
1213:from the original on 27 October 2020
1167:from the original on 20 October 2020
1130:from the original on 26 October 2020
984:from the original on 25 January 2021
946:(median 11.9 months vs. 7.8 months;
913:when administered during pregnancy.
832:highly active antiretroviral therapy
195:
1300:"2020 First Generic Drug Approvals"
535:
426:
24:
1453:from the original on 27 April 2023
1280:from the original on 29 March 2021
1239:. Celgene Europe Ltd. p. 22.
1078:from the original on 3 August 2023
1044:from the original on 10 April 2023
1014:from the original on 18 March 2023
923:
25:
3362:
1447:U.S. Food and Drug Administration
1377:U.S. Food and Drug Administration
1304:U.S. Food and Drug Administration
1246:from the original on 27 June 2016
222:
154:
3298:
1687:10.1111/j.1365-2141.2008.07013.x
1650:10.1016/j.pharmthera.2019.06.004
1393:
1353:
1157:"Pomalyst- pomalidomide capsule"
640:
634:
40:
1768:
1739:
1709:
1665:
1637:Pharmacology & Therapeutics
1624:
1597:
1532:
1465:
1435:
1423:from the original on 8 May 2023
1405:
1383:from the original on 9 May 2023
1365:
1292:
1258:
916:Pomalidomide is present in the
904:
802:
737:Key:UVSMNLNDYGZFPF-UHFFFAOYSA-N
1675:British Journal of Haematology
1443:"Cancer Accelerated Approvals"
1419:(Press release). 15 May 2020.
1226:
1112:
1098:"Pomalyst Product information"
1090:
1056:
1026:
996:
935:reported 'promising results'.
920:of people receiving the drug.
646:
628:
248:
235:
13:
1:
3331:Cereblon E3 ligase modulators
1796:10.1016/s1470-2045(13)70380-2
1746:Tefferi A (8 December 2008).
1583:10.1016/S0093-7754(01)90031-4
959:
887:as well as downregulation of
768:, sold under the brand names
1934:dihydroorotate dehydrogenase
1272:Food and Drug Administration
7:
1913:purine synthesis inhibitors
10:
3367:
1074:(published 4 April 2023).
780:used for the treatment of
618:Chemical and physical data
3055:
2983:
2956:
2841:
2484:
2186:
2177:
2168:
2161:
2114:
2098:IL-1 receptor antagonists
2096:
2087:
2041:
1972:
1902:
1893:
1539:Altman D (2 April 2013).
1417:National Cancer Institute
1337:National Cancer Institute
1205:European Medicines Agency
956:vs. dexamethasone alone.
940:progression-free survival
745:
720:
700:
690:
668:
655:
622:
617:
598:
566:
546:
526:
506:
486:
466:
446:
421:
401:
381:
376:
372:Urine (73%), faeces (15%)
366:
353:
324:
314:
304:
296:
244:(Immunosuppressive drugs)
212:
207:
182:
168:
142:
95:
81:
63:
53:
48:
39:
2971:Anti-lymphocyte globulin
2966:Anti-thymocyte globulin
1878:Immunosuppressive drugs
1072:Diário Oficial da União
909:Pomalidomide can cause
2771:Interleukin-6 receptor
2197:Complement component 5
1499:10.1073/pnas.91.9.4082
838:Origin and development
778:anti-cancer medication
1209:. 17 September 2018.
911:harm to unborn babies
1784:The Lancet. Oncology
1723:. 11 December 2008.
1571:Seminars in Oncology
1339:. 13 February 2013.
1306:. 23 February 2021.
828:proteasome inhibitor
1490:1994PNAS...91.4082D
1276:. 8 February 2013.
1163:. 7 December 2017.
1010:. 5 December 2022.
855:Mechanism of action
268:(Prescription only)
231:(Prescription only)
159: X (High risk)
36:
3341:Immunosuppressants
3128:Diroximel fumarate
2801:IL-2 receptor/CD25
2229:Certolizumab pegol
1882:Immunosuppressants
797:generic medication
32:
3286:
3285:
3133:Efgartigimod alfa
3123:Dimethyl fumarate
3051:
3050:
2979:
2978:
2952:
2951:
2157:
2156:
2083:
2082:
1924:Mycophenolic acid
1790:(11): 1055–1066.
1719:(Press release).
1066:(31 March 2023).
763:
762:
681:Interactive image
568:CompTox Dashboard
288:
276:
263:
251:
239:
226:
158:
125:
108:
59:Pomalyst, Imnovid
27:Chemical compound
16:(Redirected from
3358:
3303:
3302:
3301:
3294:
2929:Telimomab aritox
2832:Zolimomab aritox
2653:CD62L/L-selectin
2391:Immunoglobulin E
2184:
2183:
2175:
2174:
2166:
2165:
2094:
2093:
1900:
1899:
1871:
1864:
1857:
1848:
1847:
1841:
1840:
1838:
1836:
1830:
1807:
1781:
1772:
1766:
1765:
1763:
1761:
1743:
1737:
1736:
1734:
1732:
1713:
1707:
1706:
1669:
1663:
1662:
1652:
1628:
1622:
1621:
1601:
1595:
1594:
1566:
1557:
1556:
1554:
1552:
1543:. Archived from
1536:
1530:
1529:
1519:
1501:
1469:
1463:
1462:
1460:
1458:
1439:
1433:
1432:
1430:
1428:
1409:
1403:
1397:
1396:
1392:
1390:
1388:
1369:
1363:
1357:
1356:
1352:
1350:
1348:
1329:
1320:
1319:
1317:
1315:
1296:
1290:
1289:
1287:
1285:
1262:
1256:
1255:
1253:
1251:
1245:
1238:
1230:
1224:
1222:
1220:
1218:
1196:
1177:
1176:
1174:
1172:
1153:
1140:
1139:
1137:
1135:
1126:. 16 June 2020.
1116:
1110:
1109:
1107:
1105:
1094:
1088:
1087:
1085:
1083:
1060:
1054:
1053:
1051:
1049:
1040:. 21 June 2022.
1030:
1024:
1023:
1021:
1019:
1000:
994:
993:
991:
989:
970:
944:overall survival
877:interferon gamma
782:multiple myeloma
759:
758:
751:
683:
663:
648:
642:
636:
630:
613:
602:
591:
590:
576:
574:
559:
539:
519:
499:
479:
459:
439:
429:
428:
414:
358:
286:
283:
274:
271:
261:
258:
250:
247:
237:
234:
224:
221:
199:
156:
153:
135:
124:
121:
118:
107:
104:
91:
77:
44:
37:
35:
31:
21:
3366:
3365:
3361:
3360:
3359:
3357:
3356:
3355:
3321:Aromatic amines
3311:
3310:
3309:
3299:
3297:
3289:
3287:
3282:
3228:Rozanolixizumab
3113:Deucravacitinib
3047:
2975:
2948:
2837:
2486:
2480:
2188:
2153:
2110:
2089:
2079:
2037:
1977:
1968:
1904:Antimetabolites
1895:
1889:
1875:
1845:
1844:
1834:
1832:
1828:
1779:
1773:
1769:
1759:
1757:
1744:
1740:
1730:
1728:
1715:
1714:
1710:
1670:
1666:
1629:
1625:
1606:Cancer Research
1602:
1598:
1567:
1560:
1550:
1548:
1537:
1533:
1470:
1466:
1456:
1454:
1441:
1440:
1436:
1426:
1424:
1411:
1410:
1406:
1394:
1386:
1384:
1379:. 15 May 2020.
1371:
1370:
1366:
1354:
1346:
1344:
1331:
1330:
1323:
1313:
1311:
1298:
1297:
1293:
1283:
1281:
1264:
1263:
1259:
1249:
1247:
1243:
1236:
1232:
1231:
1227:
1216:
1214:
1198:
1197:
1180:
1170:
1168:
1155:
1154:
1143:
1133:
1131:
1118:
1117:
1113:
1103:
1101:
1100:. Health Canada
1096:
1095:
1091:
1081:
1079:
1061:
1057:
1047:
1045:
1032:
1031:
1027:
1017:
1015:
1002:
1001:
997:
987:
985:
980:. 14 May 2020.
972:
971:
967:
962:
926:
924:Clinical trials
907:
857:
840:
805:
754:
752:
749:(what is this?)
746:
741:
738:
733:
728:
727:
716:
713:
708:
707:
696:Racemic mixture
686:
661:
651:
645:
639:
633:
594:
570:
562:
542:
522:
502:
482:
462:
442:
425:
417:
397:
394:
389:
388:
356:
316:Protein binding
306:Bioavailability
298:Pharmacokinetic
292:
203:
171:
164:
145:
138:
28:
23:
22:
15:
12:
11:
5:
3364:
3354:
3353:
3348:
3343:
3338:
3333:
3328:
3323:
3308:
3307:
3284:
3283:
3281:
3280:
3275:
3270:
3265:
3260:
3255:
3250:
3245:
3240:
3235:
3230:
3225:
3220:
3215:
3210:
3205:
3200:
3195:
3190:
3185:
3180:
3175:
3170:
3165:
3160:
3155:
3150:
3145:
3140:
3137:+hyaluronidase
3130:
3125:
3120:
3118:Deuruxolitinib
3115:
3110:
3105:
3100:
3095:
3090:
3085:
3080:
3075:
3070:
3065:
3059:
3057:
3053:
3052:
3049:
3048:
3046:
3045:
3040:
3035:
3030:
3029:
3028:
3023:
3011:
3010:
3009:
3004:
2991:
2989:
2981:
2980:
2977:
2976:
2974:
2973:
2968:
2962:
2960:
2954:
2953:
2950:
2949:
2947:
2946:
2941:
2936:
2931:
2926:
2921:
2916:
2911:
2906:
2901:
2896:
2891:
2886:
2881:
2876:
2871:
2866:
2861:
2856:
2851:
2845:
2843:
2839:
2838:
2836:
2835:
2822:
2821:
2820:
2819:
2814:
2809:
2796:
2795:
2794:
2793:
2781:
2780:
2779:
2767:
2766:
2765:
2760:
2748:
2747:
2746:
2741:
2736:
2724:
2723:
2722:
2711:
2710:
2709:
2708:
2703:
2691:
2690:
2689:
2677:
2676:
2675:
2663:
2662:
2661:
2649:
2648:
2647:
2642:
2630:
2629:
2628:
2623:
2611:
2610:
2609:
2604:
2599:
2594:
2591:+hyaluronidase
2584:
2572:
2571:
2570:
2558:
2557:
2556:
2544:
2543:
2542:
2537:
2532:
2520:
2519:
2518:
2513:
2508:
2503:
2490:
2488:
2482:
2481:
2479:
2478:
2477:
2476:
2463:
2462:
2461:
2460:
2455:
2434:
2433:
2432:
2431:
2418:
2417:
2416:
2415:
2402:
2401:
2400:
2399:
2386:
2385:
2384:
2383:
2370:
2369:
2368:
2367:
2362:
2357:
2352:
2347:
2342:
2337:
2332:
2327:
2322:
2317:
2312:
2307:
2302:
2297:
2292:
2287:
2282:
2277:
2272:
2267:
2262:
2249:
2248:
2247:
2246:
2241:
2236:
2231:
2226:
2221:
2208:
2207:
2206:
2205:
2192:
2190:
2181:
2172:
2163:
2159:
2158:
2155:
2154:
2152:
2151:
2146:
2141:
2136:
2131:
2126:
2120:
2118:
2112:
2111:
2109:
2108:
2102:
2100:
2091:
2085:
2084:
2081:
2080:
2078:
2077:
2076:
2075:
2067:PDE4 inhibitor
2063:
2058:
2053:
2047:
2045:
2039:
2038:
2036:
2035:
2030:
2024:
2023:
2022:
2021:
2016:
2011:
2006:
1985:
1983:
1970:
1969:
1967:
1966:
1965:
1964:
1951:
1950:
1949:
1948:
1943:
1929:
1928:
1927:
1926:
1921:
1908:
1906:
1897:
1891:
1890:
1874:
1873:
1866:
1859:
1851:
1843:
1842:
1767:
1738:
1708:
1664:
1623:
1596:
1577:(6): 597–601.
1558:
1547:on 14 May 2021
1531:
1464:
1449:. 1 May 2023.
1434:
1404:
1364:
1333:"Pomalidomide"
1321:
1291:
1257:
1225:
1200:"Imnovid EPAR"
1178:
1141:
1111:
1089:
1055:
1025:
995:
964:
963:
961:
958:
925:
922:
906:
903:
869:pentoxifylline
861:TNF inhibitors
856:
853:
839:
836:
804:
801:
790:Kaposi sarcoma
761:
760:
743:
742:
740:
739:
736:
734:
731:
723:
722:
721:
718:
717:
715:
714:
711:
703:
702:
701:
698:
697:
694:
688:
687:
685:
684:
676:
674:
666:
665:
659:
653:
652:
649:
643:
637:
631:
626:
620:
619:
615:
614:
604:
596:
595:
593:
592:
584:DTXSID40893458
579:
577:
564:
563:
561:
560:
552:
550:
544:
543:
541:
540:
532:
530:
524:
523:
521:
520:
512:
510:
504:
503:
501:
500:
492:
490:
484:
483:
481:
480:
472:
470:
464:
463:
461:
460:
452:
450:
444:
443:
441:
440:
432:
430:
419:
418:
416:
415:
407:
405:
399:
398:
396:
395:
392:
384:
383:
382:
379:
378:
374:
373:
370:
364:
363:
360:
351:
350:
328:
322:
321:
318:
312:
311:
310:73% (at least)
308:
302:
301:
294:
293:
291:
290:
281:
269:
256:
245:
232:
218:
216:
210:
209:
205:
204:
202:
201:
188:
186:
180:
179:
174:
172:administration
166:
165:
163:
162:
160:
150:
148:
140:
139:
137:
136:
119:
101:
99:
93:
92:
85:
79:
78:
71:
61:
60:
57:
51:
50:
46:
45:
26:
9:
6:
4:
3:
2:
3363:
3352:
3349:
3347:
3344:
3342:
3339:
3337:
3334:
3332:
3329:
3327:
3324:
3322:
3319:
3318:
3316:
3306:
3296:
3295:
3292:
3279:
3276:
3274:
3271:
3269:
3268:Tildrakizumab
3266:
3264:
3261:
3259:
3256:
3254:
3251:
3249:
3246:
3244:
3241:
3239:
3236:
3234:
3231:
3229:
3226:
3224:
3221:
3219:
3216:
3214:
3211:
3209:
3206:
3204:
3201:
3199:
3198:Pegcetacoplan
3196:
3194:
3191:
3189:
3186:
3184:
3181:
3179:
3176:
3174:
3171:
3169:
3166:
3164:
3161:
3159:
3156:
3154:
3151:
3149:
3146:
3144:
3141:
3138:
3134:
3131:
3129:
3126:
3124:
3121:
3119:
3116:
3114:
3111:
3109:
3108:Darvadstrocel
3106:
3104:
3101:
3099:
3096:
3094:
3091:
3089:
3086:
3084:
3081:
3079:
3076:
3074:
3071:
3069:
3066:
3064:
3061:
3060:
3058:
3054:
3044:
3041:
3039:
3036:
3034:
3031:
3027:
3024:
3022:
3019:
3018:
3017:
3016:
3015:TNF inhibitor
3012:
3008:
3005:
3003:
3000:
2999:
2998:
2997:
2993:
2992:
2990:
2987:
2982:
2972:
2969:
2967:
2964:
2963:
2961:
2959:
2955:
2945:
2942:
2940:
2937:
2935:
2932:
2930:
2927:
2925:
2922:
2920:
2917:
2915:
2912:
2910:
2907:
2905:
2902:
2900:
2897:
2895:
2892:
2890:
2887:
2885:
2882:
2880:
2877:
2875:
2872:
2870:
2867:
2865:
2862:
2860:
2857:
2855:
2852:
2850:
2847:
2846:
2844:
2840:
2833:
2829:
2828:
2824:
2823:
2818:
2815:
2813:
2810:
2808:
2805:
2804:
2803:
2802:
2798:
2797:
2792:
2789:
2788:
2787:
2786:
2782:
2778:
2775:
2774:
2773:
2772:
2768:
2764:
2761:
2759:
2756:
2755:
2754:
2753:
2749:
2745:
2742:
2740:
2737:
2735:
2732:
2731:
2730:
2729:
2725:
2721:
2718:
2717:
2716:
2713:
2712:
2707:
2704:
2702:
2699:
2698:
2697:
2696:
2692:
2688:
2685:
2684:
2683:
2682:
2681:CD147/Basigin
2678:
2674:
2671:
2670:
2669:
2668:
2664:
2660:
2657:
2656:
2655:
2654:
2650:
2646:
2643:
2641:
2638:
2637:
2636:
2635:
2631:
2627:
2624:
2622:
2619:
2618:
2617:
2616:
2612:
2608:
2605:
2603:
2600:
2598:
2595:
2592:
2588:
2585:
2583:
2580:
2579:
2578:
2577:
2573:
2569:
2566:
2565:
2564:
2563:
2559:
2555:
2552:
2551:
2550:
2549:
2545:
2541:
2538:
2536:
2533:
2531:
2528:
2527:
2526:
2525:
2521:
2517:
2514:
2512:
2509:
2507:
2504:
2502:
2501:Muromonab-CD3
2499:
2498:
2497:
2496:
2492:
2491:
2489:
2483:
2475:
2472:
2471:
2470:
2469:
2465:
2464:
2459:
2456:
2454:
2451:
2450:
2449:
2448:
2444:
2440:
2436:
2435:
2430:
2427:
2426:
2425:
2424:
2420:
2419:
2414:
2411:
2410:
2409:
2408:
2404:
2403:
2398:
2395:
2394:
2393:
2392:
2388:
2387:
2382:
2379:
2378:
2377:
2376:
2375:Interleukin 5
2372:
2371:
2366:
2363:
2361:
2358:
2356:
2355:Tildrakizumab
2353:
2351:
2348:
2346:
2343:
2341:
2338:
2336:
2333:
2331:
2328:
2326:
2323:
2321:
2318:
2316:
2313:
2311:
2308:
2306:
2303:
2301:
2298:
2296:
2293:
2291:
2288:
2286:
2283:
2281:
2278:
2276:
2273:
2271:
2268:
2266:
2263:
2261:
2258:
2257:
2256:
2255:
2251:
2250:
2245:
2242:
2240:
2237:
2235:
2232:
2230:
2227:
2225:
2222:
2220:
2217:
2216:
2215:
2214:
2210:
2209:
2204:
2201:
2200:
2199:
2198:
2194:
2193:
2191:
2189:(noncellular)
2185:
2182:
2180:
2176:
2173:
2171:
2167:
2164:
2162:Extracellular
2160:
2150:
2147:
2145:
2142:
2140:
2137:
2135:
2132:
2130:
2129:Ridaforolimus
2127:
2125:
2122:
2121:
2119:
2117:
2113:
2107:
2104:
2103:
2101:
2099:
2095:
2092:
2088:Intracellular
2086:
2074:
2071:
2070:
2069:
2068:
2064:
2062:
2059:
2057:
2054:
2052:
2049:
2048:
2046:
2044:
2040:
2034:
2031:
2029:
2026:
2025:
2020:
2017:
2015:
2012:
2010:
2007:
2005:
2002:
2001:
2000:
1999:
1995:
1991:
1987:
1986:
1984:
1981:
1975:
1971:
1963:
1960:
1959:
1958:
1957:
1953:
1952:
1947:
1946:Teriflunomide
1944:
1942:
1939:
1938:
1936:
1935:
1931:
1930:
1925:
1922:
1920:
1917:
1916:
1915:
1914:
1910:
1909:
1907:
1905:
1901:
1898:
1894:Intracellular
1892:
1887:
1883:
1879:
1872:
1867:
1865:
1860:
1858:
1853:
1852:
1849:
1827:
1823:
1819:
1815:
1811:
1806:
1801:
1797:
1793:
1789:
1785:
1778:
1771:
1755:
1751:
1750:
1742:
1726:
1722:
1718:
1712:
1704:
1700:
1696:
1692:
1688:
1684:
1680:
1676:
1668:
1660:
1656:
1651:
1646:
1642:
1638:
1634:
1627:
1619:
1615:
1612:(8): 2300–5.
1611:
1607:
1600:
1592:
1588:
1584:
1580:
1576:
1572:
1565:
1563:
1546:
1542:
1535:
1527:
1523:
1518:
1513:
1509:
1505:
1500:
1495:
1491:
1487:
1484:(9): 4082–5.
1483:
1479:
1475:
1468:
1452:
1448:
1444:
1438:
1422:
1418:
1414:
1408:
1401:
1400:public domain
1382:
1378:
1374:
1368:
1361:
1360:public domain
1342:
1338:
1334:
1328:
1326:
1309:
1305:
1301:
1295:
1279:
1275:
1273:
1267:
1261:
1242:
1235:
1229:
1212:
1208:
1206:
1201:
1195:
1193:
1191:
1189:
1187:
1185:
1183:
1166:
1162:
1158:
1152:
1150:
1148:
1146:
1129:
1125:
1121:
1115:
1099:
1093:
1077:
1073:
1069:
1065:
1059:
1043:
1039:
1035:
1029:
1013:
1009:
1005:
999:
983:
979:
975:
969:
965:
957:
955:
954:dexamethasone
951:
950:
945:
941:
936:
934:
933:myelofibrosis
929:
921:
919:
914:
912:
902:
900:
897:
892:
890:
886:
882:
878:
874:
870:
866:
862:
852:
850:
846:
835:
833:
829:
824:
822:
818:
814:
813:dexamethasone
810:
800:
798:
793:
791:
787:
783:
779:
775:
771:
767:
757:
750:
744:
735:
730:
729:
726:
719:
710:
709:
706:
699:
695:
693:
689:
682:
678:
677:
675:
672:
667:
660:
658:
654:
627:
625:
621:
616:
612:
608:
605:
603:
601:ECHA InfoCard
597:
589:
585:
581:
580:
578:
569:
565:
558:
554:
553:
551:
549:
545:
538:
534:
533:
531:
529:
525:
518:
514:
513:
511:
509:
505:
498:
494:
493:
491:
489:
485:
478:
474:
473:
471:
469:
465:
458:
454:
453:
451:
449:
445:
438:
434:
433:
431:
424:
420:
413:
409:
408:
406:
404:
400:
391:
390:
387:
380:
375:
371:
369:
365:
361:
359:
352:
348:
344:
340:
336:
332:
329:
327:
323:
319:
317:
313:
309:
307:
303:
299:
295:
289: Rx-only
282:
280:
270:
267:
257:
255:
246:
243:
233:
230:
220:
219:
217:
215:
211:
206:
198:
193:
190:
189:
187:
185:
181:
178:
175:
173:
167:
161:
152:
151:
149:
147:
141:
134:
129:
120:
117:
112:
103:
102:
100:
98:
94:
90:
86:
84:
80:
76:
72:
70:
66:
62:
58:
56:
52:
49:Clinical data
47:
43:
38:
30:
19:
3351:Phthalimides
3346:Orphan drugs
3336:Glutarimides
3278:Upadacitinib
3238:Satralizumab
3223:Ritlecitinib
3218:Risankizumab
3013:
2994:
2934:Teprotumumab
2884:Inebilizumab
2879:Fontolizumab
2859:Atorolimumab
2827:T-lymphocyte
2825:
2799:
2783:
2769:
2750:
2739:Lerdelimumab
2734:Bertilimumab
2726:
2714:
2693:
2679:
2665:
2651:
2632:
2613:
2597:Pascolizumab
2582:Obinutuzumab
2574:
2560:
2546:
2530:Clenoliximab
2522:
2506:Otelixizumab
2493:
2466:
2453:Lebrikizumab
2437:
2421:
2405:
2389:
2373:
2330:Satralizumab
2320:Risankizumab
2252:
2211:
2195:
2187:Serum target
2139:Temsirolimus
2065:
2056:Pomalidomide
2055:
2051:Lenalidomide
2009:Pimecrolimus
1988:
1962:Methotrexate
1954:
1932:
1919:Azathioprine
1911:
1896:(initiation)
1833:. Retrieved
1787:
1783:
1770:
1758:. Retrieved
1748:
1741:
1729:. Retrieved
1711:
1681:(1): 41–51.
1678:
1674:
1667:
1640:
1636:
1626:
1609:
1605:
1599:
1574:
1570:
1549:. Retrieved
1545:the original
1534:
1481:
1477:
1467:
1455:. Retrieved
1446:
1437:
1425:. Retrieved
1416:
1407:
1385:. Retrieved
1376:
1367:
1345:. Retrieved
1336:
1312:. Retrieved
1303:
1294:
1284:21 September
1282:. Retrieved
1269:
1260:
1248:. Retrieved
1228:
1217:21 September
1215:. Retrieved
1203:
1171:21 September
1169:. Retrieved
1160:
1134:21 September
1132:. Retrieved
1123:
1114:
1102:. Retrieved
1092:
1080:. Retrieved
1058:
1046:. Retrieved
1037:
1028:
1016:. Retrieved
1007:
998:
988:21 September
986:. Retrieved
977:
968:
947:
937:
930:
927:
915:
908:
905:Side effects
893:
873:Upregulation
858:
848:
844:
841:
825:
821:lenalidomide
806:
803:Medical uses
794:
773:
769:
766:Pomalidomide
765:
764:
753:
747:
355:Elimination
214:Legal status
208:Legal status
133:Pomalidomide
97:License data
34:Pomalidomide
29:
3273:Tofacitinib
3213:Ravulizumab
3203:Pirfenidone
3193:Peficitinib
3093:Canakinumab
3083:Briakinumab
3073:Bimekizumab
3068:Baricitinib
3033:Aflibercept
2944:Vepalimomab
2939:Vapaliximab
2914:Rovelizumab
2904:Pexelizumab
2894:Morolimumab
2869:Cedelizumab
2854:Anifrolumab
2849:Alemtuzumab
2807:Basiliximab
2777:Tocilizumab
2763:Vedolizumab
2758:Natalizumab
2744:Metelimumab
2687:Gavilimomab
2645:Toralizumab
2640:Teneliximab
2626:Lumiliximab
2621:Gomiliximab
2607:Ublituximab
2587:Ocrelizumab
2540:Zanolimumab
2516:Visilizumab
2474:Secukinumab
2458:Ustekinumab
2429:Elsilimomab
2413:Faralimomab
2381:Mepolizumab
2365:Ustekinumab
2360:Tocilizumab
2335:Secukinumab
2285:Canakinumab
2275:Briakinumab
2270:Bimekizumab
2265:Basiliximab
2254:Interleukin
2244:Nerelimomab
2149:Zotarolimus
2090:(reception)
2061:Thalidomide
2019:Voclosporin
2004:Ciclosporin
1998:Calcineurin
1994:Cyclophilin
1941:Leflunomide
1937:inhibitors
1835:2 September
1805:2318/150538
1643:: 132–139.
1104:16 December
901:modulator.
664: g·mol
607:100.232.884
557:ChEMBL43452
377:Identifiers
83:MedlinePlus
55:Trade names
3315:Categories
3263:Sutimlimab
3258:Spesolimab
3243:Siltuximab
3183:Olokizumab
3173:Ixekizumab
3168:Itacitinib
3158:Guselkumab
3153:Fingolimod
3148:Filgotinib
3098:Crovalimab
3088:Brodalumab
3078:Blisibimod
3043:Rilonacept
3026:Opinercept
3021:Etanercept
3007:Belatacept
2958:Polyclonal
2919:Siplizumab
2909:Reslizumab
2899:Ofatumumab
2889:Maslimomab
2874:Emapalumab
2817:Inolimomab
2812:Daclizumab
2791:Odulimomab
2706:Ruplizumab
2701:Frexalimab
2659:Aselizumab
2554:Efalizumab
2511:Teplizumab
2407:Interferon
2397:Omalizumab
2350:Spesolimab
2340:Siltuximab
2315:Rilonacept
2310:Olokizumab
2300:Ixekizumab
2295:Guselkumab
2290:Daclizumab
2280:Brodalumab
2239:Infliximab
2224:Afelimomab
2219:Adalimumab
2203:Eculizumab
2179:Monoclonal
2170:Antibodies
2144:Umirolimus
2124:Everolimus
2073:Apremilast
2033:Gusperimus
2014:Tacrolimus
1982:inhibitors
1974:Macrolides
1956:antifolate
1760:28 October
1731:28 October
960:References
863:including
809:bortezomib
669:3D model (
657:Molar mass
517:D2UX06XLB5
488:ChemSpider
448:IUPHAR/BPS
412:19171-19-8
403:CAS Number
386:IUPAC name
326:Metabolism
3253:Sirukumab
3248:Siponimod
3233:Sarilumab
3208:Ponesimod
3178:Netakimab
3163:Iptacopan
3143:Etrasimod
3103:Danicopan
3038:Alefacept
3002:Abatacept
2924:Talizumab
2864:Begelomab
2720:Belimumab
2673:Galiximab
2602:Rituximab
2568:Erlizumab
2535:Keliximab
2345:Sirukumab
2325:Sarilumab
2305:Netakimab
2234:Golimumab
2134:Sirolimus
1250:21 August
1082:15 August
978:Drugs.com
899:E3 ligase
817:indicated
788:-related
692:Chirality
368:Excretion
362:7.5 hours
357:half-life
170:Routes of
144:Pregnancy
75:Monograph
69:Drugs.com
3305:Medicine
3188:Ozanimod
3063:Avacopan
3056:Unsorted
2842:Unsorted
2752:Integrin
2485:Cellular
2260:Anakinra
2106:Anakinra
2028:Abetimus
1880: /
1826:Archived
1814:24007748
1754:Archived
1725:Archived
1703:37073246
1695:18324965
1659:31202702
1618:11956087
1591:11740816
1451:Archived
1421:Archived
1381:Archived
1341:Archived
1308:Archived
1278:Archived
1241:Archived
1211:Archived
1165:Archived
1161:DailyMed
1128:Archived
1076:Archived
1048:10 April
1042:Archived
1012:Archived
982:Archived
896:cereblon
865:rolipram
845:in vitro
776:, is an
770:Pomalyst
756:(verify)
468:DrugBank
333:(mostly
242:Class C3
184:ATC code
177:By mouth
146:category
128:DailyMed
2984:-cept (
1822:4526729
1721:Celgene
1526:7513432
1508:2364596
1486:Bibcode
1018:9 April
849:in vivo
774:Imnovid
662:273.248
624:Formula
477:DB08910
423:PubChem
343:CYP2C19
252::
200:)
194: (
192:L04AX06
130::
113::
89:a613030
18:Imnovid
3291:Portal
2996:CTLA-4
2986:Fusion
2487:target
2468:IL-17A
2445:, and
1978:other
1820:
1812:
1701:
1693:
1657:
1616:
1589:
1551:14 May
1524:
1514:
1506:
1457:12 May
1427:12 May
1387:12 May
1347:12 May
1314:12 May
1064:Anvisa
942:, and
705:SMILES
548:ChEMBL
537:D08976
497:118785
437:134780
347:CYP2D6
339:CYP3A4
337:- and
335:CYP1A2
320:12–44%
279:℞-only
277:
264:
254:℞-only
240:
227:
126:
116:by INN
109:
2785:LFA-1
2695:CD154
2548:CD11a
2447:IL-23
2443:IL-13
2439:IL-12
2043:IMiDs
1829:(PDF)
1818:S2CID
1780:(PDF)
1699:S2CID
1517:43727
1504:JSTOR
1274:(FDA)
1270:U.S.
1244:(PDF)
1237:(PDF)
1207:(EMA)
1124:(emc)
918:semen
885:IL-10
815:, is
725:InChI
671:JSmol
331:Liver
2715:BLyS
2667:CD80
2634:CD40
2615:CD23
2576:CD20
2562:CD18
2423:IL-6
2116:mTOR
1990:FKBP
1980:IL-2
1837:2019
1810:PMID
1762:2012
1733:2012
1691:PMID
1655:PMID
1614:PMID
1587:PMID
1553:2021
1522:PMID
1459:2023
1429:2023
1389:2023
1349:2023
1316:2023
1286:2020
1252:2016
1219:2020
1173:2020
1136:2020
1106:2023
1084:2023
1050:2023
1020:2023
990:2020
889:IL-6
883:and
881:IL-2
867:and
847:and
811:and
786:AIDS
784:and
772:and
528:KEGG
508:UNII
457:7348
345:and
300:data
65:AHFS
2728:CAT
2524:CD4
2495:CD3
2213:TNF
1886:L04
1800:hdl
1792:doi
1683:doi
1679:141
1645:doi
1641:202
1579:doi
1512:PMC
1494:doi
875:of
573:EPA
427:CID
266:POM
197:WHO
111:EMA
3317::
2441:,
1824:.
1816:.
1808:.
1798:.
1788:14
1786:.
1782:.
1697:.
1689:.
1677:.
1653:.
1639:.
1635:.
1610:62
1608:.
1585:.
1575:28
1573:.
1561:^
1520:.
1510:.
1502:.
1492:.
1482:91
1480:.
1476:.
1445:.
1415:.
1375:.
1335:.
1324:^
1302:.
1268:.
1202:.
1181:^
1159:.
1144:^
1122:.
1036:.
1006:.
976:.
879:,
851:.
799:.
792:.
638:11
632:13
285:EU
273:US
260:UK
249:CA
236:BR
229:S4
223:AU
155:AU
123:US
106:EU
3293::
3139:)
3135:(
2988:)
2834:)
2830:(
2593:)
2589:(
1996:/
1992:/
1976:/
1888:)
1884:(
1870:e
1863:t
1856:v
1839:.
1802::
1794::
1764:.
1735:.
1705:.
1685::
1661:.
1647::
1620:.
1593:.
1581::
1555:.
1528:.
1496::
1488::
1461:.
1431:.
1402:.
1391:.
1362:.
1351:.
1318:.
1288:.
1254:.
1221:.
1175:.
1138:.
1108:.
1086:.
1052:.
1022:.
992:.
949:p
673:)
650:4
647:O
644:3
641:N
635:H
629:C
575:)
571:(
349:)
287::
275::
262::
238::
225::
157::
67:/
20:)
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