50:
155:
Working Group on
Incidental Findings published preliminary guidelines for clinical laboratories that perform clinical exome and genome sequencing. They outlined a list of "medically actionable" pathogenic gene mutations, mostly monogenetic or single-gene disorders, which were significantly associated
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incidental brain findings increasing with age. Even in healthy subjects acting as controls in research incidental findings are not rare. As most neuroimaging studies are performed in adults, less is known about the prevalence incidental findings in children. A study in 2017 in nearly 4000 children
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Unintentional genetic findings (aka "incidentalomes") are more commonly encountered with the advent of biomedical technologies capable of quickly and reliably performing genomic analysis, such as whole-genome sequencing. As with medical imaging, the capacity to measure biologic information in the
33:
are previously undiagnosed medical or psychiatric conditions that are discovered unintentionally and during evaluation for a medical or psychiatric condition. Such findings may occur in a variety of settings, including routine medical care, during
724:
Green, Robert C.; Berg, Jonathan S.; Grody, Wayne W.; Kalia, Sarah S.; Korf, Bruce R.; Martin, Christa L.; McGuire, Amy L.; Nussbaum, Robert L.; O’Daniel, Julianne M. (July 2013).
54:
84:; however a small percentage do turn out to be malignant. Incidentalomas are common, with up to 7% of all patients over 60 harboring a benign growth, often of the
131:. They often remain undiagnosed, and are often an incidental finding during autopsy. Microadenomas (<10mm) have an estimated prevalence of 16.7% (14.4% in
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Furtado CD, Aguirre DA, Sirlin CB, et al. (2005). "Whole-body CT screening: spectrum of findings and recommendations in 1192 patients".
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between 8 and 12 reported that approximately 1 in 200 children showed asymptomatic incidental findings that required clinical follow-up.
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with important medical diagnoses and which should be reported to the patient "regardless of the proband’s phenotype or age".
17:
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67:
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103:" as part of health screening programs, the chance of finding incidentalomas is expected to increase.
726:"ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing"
385:"Incidental findings on brain magnetic resonance imaging: systematic review and meta-analysis"
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form of genetic variation may exceed the scientific understanding of what the findings mean.
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may have abnormal findings that need further evaluation and with the increase of "whole-body
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Undiagnosed medical or psychiatric conditions discovered unintentionally during evaluation
8:
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Ezzat S, Asa SL, Couldwell WT, Barr CE, Dodge WE, Vance ML, McCutcheon IE (August 2004).
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found by coincidence which is often benign and does not cause any clinically significant
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Kohane, Isaac S.; Masys, Daniel R.; Altman, Russ B. (2006-07-12). "The
Incidentalome".
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322:"President's Bioethics Panel Weighs in on How U.S. Should Handle Incidental Findings"
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532:"Incidental Findings on Brain Imaging in the General Pediatric Population"
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630:"Practical pituitary pathology: what does the pathologist need to know?"
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Incidental findings in neuroimaging are common, with the prevalence of
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434:"A system for addressing incidental findings in neuroimaging research"
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273:"Incidental findings in genetics research using archived DNA"
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483:"Incidental findings on brain and spine imaging in children"
581:"The prevalence of pituitary adenomas: a systematic review"
175:"The Law of Incidental Findings in Human Subjects Research"
55:
Presidential
Commission for the Study of Bioethical Issues
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383:
Ladd SC, Warlow C, Wardlaw JM, et al. (Aug 2009).
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Cramer SC, Wu J, Hanson JA, et al. (Apr 2011).
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224:"Autopsy after traumatic death--a shifting paradigm"
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222:Light TD, Royer NA, Zabell J, et al. (2011).
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153:American College of Medical Genetics and Genomic
92:is used for the analysis of unrelated symptoms.
530:Jansen PR, van der Lugt A, White T (Oct 2017).
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173:Wolf S.M.; Paradise J.; Caga-anan C. (2008).
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127:, and account for about 15% of intracranial
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179:Journal of Law, Medicine & Ethics
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320:Couzin-Frankel, Jennifer (2013).
450:10.1016/j.neuroimage.2010.11.091
289:10.1111/j.1748-720X.2008.00271.x
191:10.1111/j.1748-720X.2008.00281.x
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536:New England Journal of Medicine
481:Maher CO, Piatt JH (Apr 2015).
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31:Incidental medical findings
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68:Incidental imaging finding
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362:10.1148/radiol.2372041741
240:10.1016/j.jss.2009.07.009
88:, which is detected when
119:Pituitary adenomas are
687:10.1001/jama.296.2.212
634:Arch. Pathol. Lab. Med
628:Asa SL (August 2008).
500:10.1542/peds.2015-0071
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57:on incidental findings
135:studies and 22.5% in
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38:, during post-mortem
730:Genetics in Medicine
548:10.1056/NEJMc1710724
788:Medical terminology
742:10.1038/gim.2013.73
327:news.sciencemag.org
271:Clayton EW (2008).
36:biomedical research
598:10.1002/cncr.20412
493:(4): e1084–e1096.
123:that occur in the
90:diagnostic imaging
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18:Incidental finding
542:(16): 1593–1595.
401:10.1136/bmj.b3016
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107:Neuroimaging
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42:, or during
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333:13 December
101:CT scanning
659:2008-09-03
557:1887/92310
487:Pediatrics
438:NeuroImage
228:J Surg Res
160:References
139:studies).
137:radiologic
113:neoplastic
750:1530-0366
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395:: b3016.
350:Radiology
129:neoplasms
782:Category
768:23788249
703:16835427
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566:29045203
509:25825535
468:21224007
419:19687093
370:16170016
307:18547196
258:20031159
209:18547206
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759:3727274
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675:JAMA
650:PMID
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335:2013
303:PMID
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738:doi
683:doi
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552:hdl
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