351:
2012 Bulawa, C.E.; Connelly, S.; DeVit, M.; Wang, L. Weigel, C.;Fleming, J. Packman, J.; Powers, E.T.; Wiseman, R.L.; Foss, T.R.; Wilson, I.A.; Kelly, J.W.; Labaudiniere, R. “Tafamidis, A Potent and
Selective Transthyretin Kinetic Stabilizer That Inhibits the Amyloid Cascade” Proc. Natl. Acad. Sci.
322:
2002 Sawkar, A.R.; Cheng, W-C.; Beutler, E.: Wong, C.–H.: Balch, W.E.: Kelly, J.W. "Chemical
Chaperones Increase the Cellular Activity of N370S β-glucosidase: A Therapeutic Strategy for Gaucher Disease " Proc. Natl. Acad. Sci. 99, 15428-15433.
157:
He is former Dean of
Graduate Studies (2000–2008) and Vice President of Academic Affairs (2000–2006) and co-Chairman of Molecular Medicine and the Lita Annenberg Hazen Professor of Chemistry within the Skaggs Institute of Chemical Biology at The
347:
2011 Culyba, E.K.; Price, J.L.; Hanson, S.R.; Dhar, A,; Wong, C-H.; Gruebele, M.; Powers, E.T.; Kelly, J.W. “Protein Native State
Stabilization by Placing Aromatic Side Chains in N-Glycosylated Reverse Turns” Science 331, 571-575.
166:. His research focuses on understanding protein folding, misfolding and aggregation and on developing both chemical and biological strategies to ameliorate diseases caused by protein misfolding and/or aggregation.
355:
2013 Chen, W; Enck, S.; Price, J.L.; Powers, D.L.; Powers, E.T.; Wong, C-H.; Dyson, H.J.; Kelly, J.W. “The
Structural and Energetic Basis of Protein-Carbohydrate Interactions” J. Am. Chem. Soc. 135, 9877-9884.
338:
2008 Mu, T-W.; Ong, D.S.T.; Wang, Y-J; Balch, W. E.; Yates, J.R.; Segatori, L.; Kelly, J.W. .”Chemical and
Biological Approaches Synergize to Ameliorate Protein-Folding Diseases” Cell 134, 769-781.
332:
2005 Sekijima, Y., Wiseman, R.L., Matteson, J., Hammarström, P., Miller,S.R., Balch, W.E., Kelly, J.W. “Biological and
Chemical Basis for Tissue Selective Amyloid Disease”Cell 121, 73-85.
474:
Labaudiniere, Richard (2014). "Chapter 9: Discovery and
Development of Tafamidis for the Treatment of TTR Familial Amyloid Polyneuropathy". In Pryde, David C; Palmer, Michael J (eds.).
329:
2004 Deechongkit, S.; Nguyen, H.; Dawson, P.E.; Gruebele, M.; Kelly, J.W. “Context
Dependent Contributions of Backbone H-Bonding to β-Sheet Folding Energetics” Nature 430, 101-105.
326:
2003 Hammarstrom, P.; Wiseman, R. L.; Powers, E.T.; Kelly, J.W. "Prevention of
Transthyretin Amyloid Disease by Changing Protein Misfolding Energetics" Science 299, 713-716.
335:
2006 Fowler, D.M.; Koulov, A.V.; Alory-Jost, C.; Marks, M.S.; Balch, W.E; Kelly, J.W. "Functional Amyloid Formation Within Mammalian Tissue " PLoS Biology 4, 100-107.
423:
456:
1035:
531:
Breznitz, Shiri M.; O'Shea, Rory P.; Allen, Thomas J. (March 2008). "University Commercialization Strategies in the Development of Regional Bioclusters".
1025:
313:
1992 Colon, W.; Kelly, J.W. "Partial Denaturation of Transthyretin is Sufficient for Amyloid Fibril Formation In Vitro." Biochemistry, 31 8654-8660.
596:
316:
2001 Jager, M.; Nguyen, H.; Crane, J.C.; Kelly, J.W.; Gruebele, M. "The Folding Mechanism of a β-Sheet: The WW Domain" J. Mol. Biol., 311, 373-393.
1030:
1015:
62:
1060:
1055:
67:
341:
2008 Balch, W.E.; Morimoto, R.I.; Dillin, A.; Kelly, J.W. “Adapting Proteostasis For Disease Intervention” Science 319, 916-919.
1020:
319:
2001 Hammarstrom, P.; Schneider, F.; Kelly, J.W. "Trans-Suppression of Misfolding In An Amyloid Disease" Science 293, 2459-2461.
1045:
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80:
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tafamidis up through submitting an application for marketing approval in Europe in early 2010. FoldRx was acquired by
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424:"Proteostasis, with San Diego Roots and Boston Home, Seeks Edge in Alzheimer's and Parkinson's"
151:
772:
1005:
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strategy; the structure was first published in 2003. In 2003 Kelly co-founded FoldRx with
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247:
2012 - American Chemical Society, Ralph F. Hirschmann Award in Peptide Chemistry
197:
170:
815:
377:
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Kelly has cofounded three biotechnology companies, FoldRx Pharmaceuticals with
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457:"J&J Creates Space at Janssen Labs for Life Sciences Entrepreneurs"
85:
130:) is an American businessman and chemist who is on the faculty of the
566:
189:
517:
975:
150:
at Chapel Hill (1986) and performed post-doctoral research at The
241:
2011 - American Peptide Society Rao Makineni Lectureship (Award)
478:. RSC Drug Discovery Series No. 38. Royal Society of Chemistry.
504:
Jones, Dan (October 29, 2010). "Modifying protein misfolding".
229:
2000 - SUNY at Fredonia Alumni Distinguished Achievement Award
205:
232:
2001 - American Chemical Society Arthur C. Cope Scholar Award
444:. Proteostasis Therapeutics via SEC Edgar. December 23, 2015.
604:
238:
2008 - American Peptide Society Vincent du Vigneaud Award
530:
265:
Jacob Heskel Gabbay Award in Biotechnology and Medicine
226:
1999 - Protein Society-Dupont Young Investigator Award
146:
Kelly received his Ph.D. in organic chemistry from the
395:
Borman, Stu (January 25, 2010). "Attacking Amyloids".
223:
1999 - Biophysical Society National Lecturer (Award)
192:was eventually discovered by Kelly's team using a
557:see Commencement address at: youtu.be/4YA7btif6A8
235:2006 - National Institutes of Health Merit Award
997:
269:2016 - Commencement address at SUNY Fredonia.
200:of MIT and the Whitehead Institute and FoldRx
173:in 2003, Proteostasis Therapeutics, Inc. with
1036:Businesspeople in the pharmaceutical industry
590:
181:in 2010, and Misfolding Diagnostics in 2012.
473:
244:2011 - Protein Society Emil T. Kaiser Award
16:American businessman and chemist (born 1960)
63:University of North Carolina at Chapel Hill
597:
583:
499:
497:
495:
184:His lab began looking for ways to inhibit
1026:American chemical industry businesspeople
421:
390:
388:
386:
533:Journal of Product Innovation Management
68:State University of New York at Fredonia
492:
454:
998:
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383:
373:
371:
369:
578:
503:
308:
278:2017 - Chemical Pioneer Award of the
274:American Academy of Arts and Sciences
1031:Businesspeople from New York (state)
1016:21st-century American businesspeople
455:Preston, Juliet (February 5, 2013).
211:
366:
344:2010 Wiley; died in a car crash
298:Breakthrough Prize in Life Sciences
81:Breakthrough Prize in Life Sciences
13:
380:, Scripps, Retrieved April 2, 2018
14:
1072:
1061:Wolf Prize in Chemistry laureates
1056:Scientists from New York (state)
545:10.1111/j.1540-5885.2008.00290.x
188:fibril formation in the 1990s.
560:
422:Timmerman, Luke (May 3, 2010).
397:Chemical & Engineering News
1021:21st-century American chemists
551:
524:
476:Orphan Drugs and Rare Diseases
467:
448:
434:
415:
280:American Institute of Chemists
1:
506:Nature Reviews Drug Discovery
359:
292:National Academy of Inventors
252:Murray Goodman Memorial Prize
1046:People from Medina, New York
567:Wolf Prize in Chemistry 2023
148:University of North Carolina
141:
7:
194:structure-based drug design
10:
1077:
286:Royal Society of Chemistry
258:Royal Society of Chemistry
160:Scripps Research Institute
132:Scripps Research Institute
107:Scripps Research Institute
1041:American organic chemists
944:
861:
798:
729:
636:
613:
409:10.1021/cen-v088n004.p030
126:(born August 23, 1960 in
117:
99:
92:
76:
55:
30:
23:
1051:Scripps Research faculty
877:Krzysztof Matyjaszewski
607:Wolf Prize in Chemistry
304:Wolf Prize in Chemistry
250:2012 - the Biopolymers
152:Rockefeller University
773:Samuel J. Danishefsky
290:2017 - Fellow of the
284:2017 - Fellow of the
272:2016 - Member of the
260:Jeremy Knowles Award
710:Raphael David Levine
656:John Charles Polanyi
164:La Jolla, California
136:La Jolla, California
970:Benjamin F. Cravatt
966:Carolyn R. Bertozzi
931:Stephen L. Buchwald
670:Harden M. McConnell
666:Herbert S. Gutowsky
952:Leslie Leiserowitz
848:William E. Moerner
820:K. Barry Sharpless
690:Albert Eschenmoser
660:George C. Pimentel
309:Significant Papers
993:
992:
962:Bonnie L. Bassler
915:Robert G. Bergman
887:Charles M. Lieber
783:Gabor A. Somorjai
720:Alan R. Battersby
696:David C. Phillips
686:Elias James Corey
680:Rudolph A. Marcus
605:Laureates of the
485:978-1-84973-806-4
378:Faculty biography
212:Honors and awards
208:later that year.
121:
120:
94:Scientific career
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984:Jeffery W. Kelly
909:Stuart Schreiber
893:Robert S. Langer
806:F. Albert Cotton
737:Richard R. Ernst
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352:109, 9629-9634.
179:Richard Morimoto
128:Medina, New York
124:Jeffery W. Kelly
48:Medina, New York
44:
40:
38:
25:Jeffery W. Kelly
21:
20:
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996:
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935:John F. Hartwig
883:Paul Alivisatos
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832:Richard N. Zare
794:
789:Raymond Lemieux
741:Alexander Pines
725:
632:
609:
603:
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572:
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518:10.1038/nrd3316
512:(11): 825–827.
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198:Susan Lindquist
171:Susan Lindquist
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56:Alma mater
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41:August 23, 1960
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905:K. C. Nicolaou
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873:Ching Wan Tang
869:Stuart A. Rice
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812:Henri B. Kagan
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759:Richard Lerner
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539:(2): 129–142.
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218:Searle Scholar
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925:Makoto Fujita
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921:Omar M. Yaghi
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899:Chi-Huey Wong
897:
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826:Harry B. Gray
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769:Gilbert Stork
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763:Peter Schultz
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674:John S. Waugh
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621:Carl Djerassi
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175:Andrew Dillin
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43:(age 64)
33:
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22:
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983:
980:Hiroaki Suga
842:George Feher
816:RyĹŤji Noyori
779:Gerhard Ertl
753:Ahmed Zewail
650:Joseph Chatt
644:Henry Eyring
562:
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403:(4): 30–32.
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100:Institutions
93:
18:
1006:1960 births
627:Herman Mark
154:(1986–89).
1000:Categories
956:Meir Lahav
838:Ada Yonath
747:John Pople
700:David Blow
442:"Form S-1"
360:References
86:Wolf Prize
37:1960-08-23
202:developed
190:Tafamidis
142:Biography
976:Chuan He
844:(2006/7)
775:(1995/6)
765:(1994/5)
682:(1984/5)
676:(1983/4)
461:Xconomy
428:Xconomy
302:2023 -
296:2022 -
263:2016 -
256:2016 -
216:1991 -
986:(2023)
972:(2022)
958:(2021)
937:(2019)
927:(2018)
917:(2017)
911:(2016)
901:(2014)
895:(2013)
889:(2012)
879:(2011)
854:(2008)
834:(2005)
828:(2004)
822:(2001)
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755:(1993)
749:(1992)
743:(1991)
722:(1989)
712:(1988)
702:(1987)
692:(1986)
662:(1982)
652:(1981)
646:(1980)
629:(1979)
623:(1978)
482:
220:Award
206:Pfizer
88:(2023)
83:(2022)
77:Awards
50:, U.S.
945:2020s
862:2010s
799:2000s
730:1990s
637:1980s
614:1970s
480:ISBN
177:and
31:Born
541:doi
514:doi
405:doi
162:in
134:in
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978:/
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