457:
1740:
606:. Among his contributions are the findings that cell surface receptors with tyrosine kinase activity signal across membrane by forming dimers when they bind to their growth factor activators. He discovered this in studies of the
1354:
856:
to develop ATP-like molecules that would compete with ATP for binding to the catalytic site of receptor tyrosine kinases in cancer treatment. In 1999, Sugen was acquired by
Pharmacia & Upjohn for $ 650 million and in 2003,
1284:
149:, which is important in many areas of cellular regulation, especially growth control and cancer. Schlessinger's work has led to an understanding of the mechanism of transmembrane signaling by receptor
1014:
485:
404:. He has lectured at many institutions, including the Harvey Society (in the 1993–1994 Harvey Lectures series) and the 2006 Keith R. Porter Lecture of the American Society for Cell Biology.
836:
lawsuit was initiated against Yale
University by Schlessinger's former secretary, Mary Beth Garceau, who alleged numerous episodes of harassment during her employment at Yale and claimed
285:
He is married to Irit Lax, also a professor in the pharmacology department at Yale. They each have two children by previous marriages. In a 2009 interview with a
Croatian daily newspaper
1872:
291:, he said, "Basically I am atheist. I grew up Jewish and I truly belong to the Jewish culture, but I'm not a follower of any world religion. Religion does not interest me at all."
385:
Schlessinger is the recipient of numerous prizes, including the
Michael Landau Prize (1973), the Sara Leady Prize (1980), the Hestrin Prize (1983), the Levinson Prize (1984), a
840:
failed to act upon her frequent complaints, causing her to resign. The case was settled out of court in mid-2007 and the terms of the settlement were not publicly disclosed.
575:, Schlessinger has authored over 450 scientific original and review articles in the areas of pharmacology, molecular biology, biochemistry, and structural biology, mostly on
614:
controls tyrosine kinase signaling by binding to phosphorylated tyrosines in activated receptors. One of the seminal findings in this work was his laboratory's cloning of
299:
Schlessinger was a member of the faculty of the
Weizmann Institute from 1978 to 1991 and was the Ruth and Leonard Simon Professor of Cancer Research in the department of
1877:
1288:
889:). Plexxikon, uses a pioneering structural biology-based platform for drug discovery. In April 2011, Plexxikon was acquired by the Japanese pharmaceutical company
1728:
913:
1026:
902:
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637:
as one of the world's top 30 most cited scientists (across all fields) in the 1990s. According to ISI, his papers have been cited a total of 76,699 times.
418:
selected
Schlessinger to receive its Award of Excellence for Clinical Development. In 2009, Schlessinger was given an award by then-President of Croatia
1897:
598:
Tyrosine kinases play a particularly important role in cancer, and several agents that block their activity are now used as anti-cancer drugs, such as
1042:
Ha-Kol (Glasilo Židovske zajednice u
Hrvatskoj); Joseph Schlessinger odlikovan visokim Hrvatskim odliÄŤjem; stranica 54; broj 111, listopad/rujan 2009.
422:
for outstanding service in promoting
Croatia in the international scientific community and for the contribution within Croatian biomedical sciences.
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489:
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142:, Connecticut, as well as the founding director of the school's new Cancer Biology Institute. His area of research is signaling through
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in the
Biomedicine category for "carving out the path that led to the development of a new class of successful cancer drugs."
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934:"Schlessinger Appointed Director of New Cancer Biology Institute at Yale – Yale Office of Public Affairs & Communication"
408:
339:
307:, from 1985 to 1990. In 1990, he was appointed as the Milton and Helen Kimmelman Professor and chairman of the department of
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION - FORM S-1- REGISTRATION STATEMENT KOLLTAN PHARMACEUTICALS, INC (filing)
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in 1974. From 1974 to 1976, he was a postdoctoral fellow in the
Departments of Chemistry and Applied Physics at
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signaling. Tyrosine kinase signaling plays a critical role in the control of many cellular processes including
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In April 2014, Kolltan received $ 60 million in equity financing. In September 2014, Kolltan filed for an
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1741:"What is the history of Arthur G. Altschul Jr and the latest information about Arthur G. Altschul Jr?"
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Kolltan Pharmaceuticals is an early-stage biotech that develops antibodies to treat solid tumors.
246:
in 1968 (magna cum laude), and an MSc degree in chemistry (also magna cum laude) in 1970 from the
1802:
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1529:
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532:
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The family moved to Israel in 1948. Schlessinger served his compulsory military service with the
216:, where another son, Darko David, was born. Imre Schlessinger once made a joke at the expense of
1842:
1827:
1332:
198:
139:
1015:"Joseph Schlessinger: Borio sam se za Izrael, izumio Sutent. Sad mogu natrag u svoju Hrvatsku"
869:), approved by the FDA for treating gastrointestinal stromal tumors and renal cell carcinoma.
343:
1058:
273:, among others. From 1977 to 1978, he was a visiting fellow in the immunology branch of the
1817:
1604:
1115:
1803:
Yale School of Medicine appoints Joseph Schlessinger, formerly of NYU, Pharmacology Chair.
768:"Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma"
8:
1778:
Genetic Engineering and Biotechnology News: "Celldex to Acquire Kolltan for Up to $ 235M"
401:
55:
1795:
1530:
Yale ex-secretary sues for sex harassment From publication: "Women in Higher Education"
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988:
963:
865:. One of the pipeline products (SU11248) was ultimately developed by Pfizer as Sutent (
802:
767:
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323:
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from 1985 to 1991. In addition, he was a research director for Rorer Biotechnology in
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and was commissioned an officer. As part of his reserve duty he participated in the
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parachute. He was named for his grandfather. After World War II the family moved to
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651:(20 April 1990). "Signal transduction by receptors with tyrosine kinase activity".
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389:(1995), the Antoine Lacassagne Prize (1995), the Taylor Prize (2000), and the
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for $ 805 million and an additional $ 130 m in potential milestone payments.
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listed him as number 14 in the "Giants of Science". He received, along with
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Gideon Bollag; Peter Hirth; James Tsai; et al. (30 September 2010).
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1429:"Personal Page for Schlessinger at Croatian Academy of Science and Arts"
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1206:
785:
1403:"List of Corresponding Members of Croatian Academy or Science and Arts"
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and how the resulting signals control cell growth and differentiation.
127:
1704:"Cancer biotech Kolltan Pharmaceuticals files for an $ 86 million IPO"
349:
He is a member of the editorial boards of several journals, including
1542:"Alleged Harassment by Renowned Researcher Prompts Suit Against Yale"
878:
866:
858:
239:
186:
319:'s Skirball Institute for Biomolecular Medicine, from 1998 to 2001.
194:
1766:"Cancer biotech Kolltan Pharmaceuticals withdraws $ 86 million IPO"
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143:
1518:
University of Hartford Media Watch (27 November - 4 December 2006)
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When Schlessinger was born on 26 March 1945 he was wrapped in a
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and in January 2015, they withdrew the IPO. In November 2016,
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In 2007, Schlessinger co-founded Kolltan Pharmaceuticals with
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from the article and its talk page, especially if potentially
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Los Angeles Times: "Pharmacia to Buy Sugen for $ 650 Million"
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1080:
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853:
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Pfizer corporate website: "2003:Pfizer and Pharmacia Merger"
1661:
1355:"NCBI Pubmed Citation of Harvey Lecture by J. Schlessinger"
626:
615:
166:
1073:
610:(EGFR). He was also instrumental in understanding how the
1873:
Members of the United States National Academy of Sciences
1729:"Startup's cancer therapy preps for 2014 clinical trials"
1472:
909:
1617:
1116:"Schlessinger's Departmental website at Yale University"
646:
952:
1246:
1244:
1242:
1240:
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1236:
185:; Imre's first wife and child had been deported to
1878:Foreign members of the Russian Academy of Sciences
958:
852:and Steven Evans-Freke) the biotechnology company
1233:
936:. Opac.yale.edu. 13 December 2010. Archived from
1809:
1053:
1051:
115:(born Josip Schlessinger; 26 March 1945) is a
1473:Nancy Imelda Schafer, ISI (18 October 2004).
964:"Cell Signaling by Receptor Tyrosine Kinases"
707:"Cell signaling by receptor tyrosine kinases"
220:and was sentenced to several months in jail.
193:; her first husband had been murdered by the
446:
441:BBVA Foundation Frontiers of Knowledge Award
326:Professor and chairman of the department of
1903:Members of the National Academy of Medicine
1048:
407:In 2009, he was elected as a Member of the
1520:, hartford.edu; accessed 28 February 2016.
1449:
896:
488:about living persons that is unsourced or
336:United States National Academy of Sciences
1898:Israeli people of Croatian-Jewish descent
1754:"With $ 60 million, cancer drug develops"
1452:"Guardian article, The Giants of Science"
1254:. Hcr3.isiknowledge.com. 31 December 2011
1140:. .nationalacademies.org. 24 October 2005
1138:"News release from Institute of Medicine"
987:
801:
740:
629:, which is critical for signaling by the
559:Learn how and when to remove this message
380:
1731:, hartfordbusiness.com, 13 January 2014.
1570:"Another Lawsuit Against the University"
1219:"AAAS/Science STKE Editorial Board page"
238:Schlessinger received his BSc degree in
199:labor camp on the Adriatic island of Rab
1743:, chicagotribune.com, 27 December 2015.
1038:
1036:
848:In 1991, Schlessinger co-founded (with
189:. Schlessinger's mother Rivka was from
1810:
1532:, accessmylibrary.com, 1 January 2007.
1499:. Isihighlycited.com. 31 December 2011
1497:"ISI Highly Cited Scientists Database"
1454:. London, UK: Education.guardian.co.uk
1118:. Info.med.yale.edu. 28 September 2010
1061:. Info.med.yale.edu. 28 September 2010
640:
313:New York University School of Medicine
1684:"Daiichi Sankyo to Acquire Plexxikon"
409:Croatian Academy of Sciences and Arts
340:American Academy of Arts and Sciences
201:in 1943 and joined a group of Jewish
130:and biophysician. He is chair of the
1033:
1009:
1007:
916:acquired Kolltan for $ 235 million.
450:
13:
1756:, yaledailynews.com, 4 April 2014.
1357:. Ncbi.nlm.nih.gov. 3 October 2011
887:University of California, Berkeley
334:since 2001. He was elected to the
294:
14:
1914:
1787:
1640:"FDA news announcement on Sutent"
1287:. Dan David Prize. Archived from
1004:
877:In 2001, Schlessinger co-founded
631:Fibroblast growth factor receptor
1706:, nasdaq.com, 12 September 2014.
1558:"Univ. faces harassment lawsuit"
1450:Ian Sample (25 September 2003).
633:. In 2001, he was ranked by the
625:Another is the lab's cloning of
608:epidermal growth factor receptor
455:
280:
1868:Yale School of Medicine faculty
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1211:
1200:
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962:; Schlessinger, Joseph (2010).
591:, as well as cell survival and
161:Josip Schlessinger was born in
16:American biochemist (born 1945)
1768:, nasdaq.com, 28 January 2015.
1607:; retrieved 29 September 2015.
1560:, Yale Daily News, 1 Dec. 2006
1405:. Info.hazu.hr. Archived from
1184:. Molecule.org. Archived from
1182:"Molecular Cell masthead link"
1152:
1130:
1108:
926:
827:
416:Hope Funds for Cancer Research
253:He obtained his PhD degree in
248:Hebrew University of Jerusalem
165:to Jewish parents. His father
1:
1546:Chronicle of Higher Education
1313:. Eurekalert.org. 24 May 2006
1285:"Joseph Schlessinger profile"
1094:"Schlessinger Lab: Biography"
919:
305:King of Prussia, Pennsylvania
259:Weizmann Institute of Science
1888:Yugoslav emigrants to Israel
1883:Croatian emigrants to Israel
872:
667:10.1016/0092-8674(90)90801-K
466:biography of a living person
156:
7:
1207:J. Cell Biol. Masthead site
493:must be removed immediately
396:In 2002, he was granted an
315:. He served as director of
10:
1919:
1642:. Fda.gov. 26 January 2006
1379:. Ascb.org. Archived from
1377:"Porter lecture laureates"
980:10.1016/j.cell.2010.06.011
725:10.1016/J.CELL.2010.06.011
197:. Imre and Rivka met in a
1273:Taylor Prize announcement
447:Publications and research
275:National Cancer Institute
106:
96:
89:
73:
63:
30:
23:
1863:Jewish American atheists
1311:"Dan David announcement"
843:
1475:"ISI InCites Interview"
897:Kolltan Pharmaceuticals
364:Journal of Cell Biology
332:Yale School of Medicine
1575:8 October 2007 at the
1335:. Research.haifa.ac.il
480:Please help by adding
381:Awards and recognition
138:School of Medicine in
1333:"University of Haifa"
1221:. Stke.sciencemag.org
508:"Joseph Schlessinger"
344:Institute of Medicine
1838:American biochemists
1718:, 12 September 2014.
1662:"Plexxikon web site"
1581:Yale Alumni Magazine
1160:"Cell masthead link"
914:Celldex Therapeutics
486:Contentious material
342:in 2001, and to the
1853:Israeli biochemists
1823:People from Topusko
1548:], 2 December 2006.
1409:on 25 February 2010
1252:"CV on ISI Website"
1029:on 16 October 2012.
960:Lemmon, Mark Andrew
903:Arthur Altschul Jr.
786:10.1038/NATURE09454
703:Joseph Schlessinger
641:Select publications
425:In September 2003,
402:University of Haifa
113:Joseph Schlessinger
56:Republic of Croatia
25:Joseph Schlessinger
1291:on 29 January 2012
581:cell proliferation
464:This section of a
398:honorary doctorate
324:William H. Prusoff
317:NYU Medical Center
263:Cornell University
179:Kingdom of Hungary
175:Kingdom of Hungary
35:Josip Schlessinger
1848:Croatian atheists
1833:American atheists
834:sexual harassment
569:
568:
561:
543:
469:needs additional
375:Science Signaling
110:
109:
91:Scientific career
1910:
1893:Israeli atheists
1799:
1798:
1796:Official website
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1618:"Sutent website"
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1188:on 16 April 2008
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1030:
1025:. Archived from
1011:
1002:
1001:
991:
974:(7): 1117–1134.
956:
950:
949:
947:
945:
930:
861:was acquired by
823:
805:
762:
744:
705:(25 June 2010).
694:
635:ISI Highly Cited
620:Adaptor proteins
564:
557:
553:
550:
544:
542:
501:
482:reliable sources
459:
458:
451:
338:in 2000, to the
322:He has been the
267:Ithaca, New York
210:British military
151:tyrosine kinases
48:
44:
42:
21:
20:
1918:
1917:
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1911:
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1858:Jewish chemists
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1780:2 November 2016
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1664:. Plexxikon.com
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1595:, 16 June 1999.
1591:
1587:
1577:Wayback Machine
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1021:(in Croatian).
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1005:
957:
953:
943:
941:
940:on 24 July 2011
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931:
927:
922:
899:
875:
846:
838:Yale University
830:
780:(7315): 596–9.
643:
585:differentiation
577:tyrosine kinase
565:
554:
548:
545:
502:
500:
479:
460:
456:
449:
433:Charles Sawyers
391:Dan David Prize
387:Ciba-Drew Award
383:
297:
295:Academic career
283:
269:, working with
159:
147:phosphorylation
136:Yale University
85:
82:Dan David Prize
78:Ciba-Drew Award
68:
59:
54:, (present-day
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1788:External links
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1727:Pablo Robles,
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1585:
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1488:
1477:. In-cites.com
1465:
1442:
1431:. Info.hazu.hr
1420:
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1368:
1346:
1324:
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1265:
1232:
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1199:
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1129:
1107:
1096:. Med.yale.edu
1072:
1059:"The long war"
1047:
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924:
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898:
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891:Daiichi Sankyo
874:
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829:
826:
825:
824:
763:
719:(7): 1117–34.
695:
649:J Schlessinger
642:
639:
567:
566:
490:poorly sourced
463:
461:
454:
448:
445:
382:
379:
358:Molecular Cell
296:
293:
282:
279:
233:Yom Kippur War
225:Golani Brigade
158:
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134:Department at
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45:26 March 1945
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1620:. Sutent.com
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101:Pharmacology
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1689:28 February
1019:jutarnji.hr
832:In 2006, a
828:Controversy
647:A Ullrich;
439:, the 2014
437:Tony Hunter
229:Six-Day War
64:Nationality
1812:Categories
1752:J.R. Reed
1668:16 January
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1162:. Cell.com
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1100:16 January
1065:16 January
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920:References
618:and other
612:SH2 domain
589:metabolism
519:newspapers
367:, and the
301:immunology
255:biophysics
169:came from
128:biochemist
41:1945-03-26
879:Plexxikon
873:Plexxikon
867:Sunitinib
859:Pharmacia
820:Q24597152
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400:from the
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346:in 2005.
257:from the
240:Chemistry
203:Partisans
187:Auschwitz
171:Szalatnok
157:Biography
140:New Haven
1573:Archived
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600:Imatinib
497:libelous
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144:tyrosine
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311:at the
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