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sequences. This analysis showed signals of "10 invariant and almost invariant glycines" as well as signals of hypervariable regions. Kabat produced the first numbering scheme in 1970.
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based upon variable regions. The scheme is useful when comparing these variable regions between antibodies. Its foundations were laid by the
American biomedical scientist
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108:"An Analysis of the Sequences of the Variable Regions of Bence Jones Proteins and Myeloma Light Chains and Their Implications for Antibody Complementarity"
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The KabatMan (Kabat
Sequence Database) is a database collecting antibody sequences.
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The basis for the Kabat numbering scheme was laid out by a 1970s paper aligning 77
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161:"bioinf.org.uk - Prof. Andrew C.R. Martin's group at UCL"
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83:"A description of the Kabat numbering scheme"
106:Wu, Tai Te; Kabat, Elvin A. (1970-08-01).
16:Biological scheme on numbering amino acids
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23:is a scheme for the numbering of
115:Journal of Experimental Medicine
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191:Chemical numbering schemes
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48:Chothia numbering system
201:Biological nomenclature
43:light chains in 1969.
21:Kabat numbering scheme
123:10.1084/jem.132.2.211
117:. pp. 211–250.
37:Bence Jones proteins
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165:www.bioinf.org.uk
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196:Antibodies
185:Categories
170:2023-02-22
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89:2013-07-26
69:References
29:antibodies
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