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Kaposi's sarcoma

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688: 700: 712: 463: 669: 587: 415: 407: 1149:, in which the main character was fired after his employers found out he was HIV-positive due to visible lesions. By the time KS lesions appear, likely, the immune system has already been severely weakened. It has been reported that only 6% of men who have sex with men are aware that KS is caused by a virus different from HIV. Thus, there is little community effort to prevent KSHV infection. Likewise, no systematic screening of organ donations is in place. 32: 1047: 2155:
Parravicini C, Olsen SJ, Capra M, Poli F, Sirchia G, Gao SJ, Berti E, Nocera A, Rossi E, Bestetti G, Pizzuto M, Galli M, Moroni M, Moore PS, Corbellino M (October 1997). "Risk of Kaposi's sarcoma-associated herpes virus transmission from donor allografts among Italian posttransplant Kaposi's sarcoma
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Blood tests to detect antibodies against KSHV have been developed and can be used to determine whether a person is at risk for transmitting the infection to their sexual partner, or whether an organ is infected before transplantation. However, these tests are not available except as research tools,
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Classic, endemic, immunosuppression therapy-related (also known as iatrogenic), and epidemic (also known as AIDS-related) sub-types are all described. Classic KS tends to affect older men in regions where KSHV is highly prevalent (Mediterranean, Eastern Europe, Middle East), is usually slow-growing,
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and may be flat or raised. Lesions can occur singly, multiply in a limited area, or may be widespread. Depending on the sub-type of disease and level of immune suppression, KS may worsen either gradually or quickly. Except for Classical KS where there is generally no immune suppression, KS is caused
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most commonly appears early on the toes and soles as reddish, violaceous, or bluish-black macules and patches that spread and coalesce to form nodules or plaques. A small percentage of these patients may have visceral lesions. In most cases the treatment involves surgical removal of the lesion. The
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patients in the 1980s, when its incidence grew rapidly. The tumor arises either when an HHV 8-infected organ is transplanted into someone who has not been exposed to the virus or when the transplant recipient already harbors pre-existing HHV 8 infection. Unlike classic Kaposi sarcoma, the site of
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In Europe and North America, KSHV is transmitted through saliva. Thus, kissing is a risk factor for transmission. Higher rates of transmission among gay and bisexual men have been attributed to "deep kissing" sexual partners with KSHV. Another alternative theory suggests that use of saliva as a
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With the decrease in the death rate among people with HIV/AIDS receiving new treatments in the 1990s, the rates and severity of epidemic KS also decreased. However, the number of people living with HIV/AIDS is increasing in the United States, and it is possible that the number of people with
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Weninger W, Partanen TA, Breiteneder-Geleff S, Mayer C, Kowalski H, Mildner M, et al. (February 1999). "Expression of vascular endothelial growth factor receptor-3 and podoplanin suggests a lymphatic endothelial cell origin of Kaposi's sarcoma tumor cells".
975:(HAART). Therefore, HAART is considered the cornerstone of therapy in AIDS-associated Kaposi sarcoma. However, in a certain percentage of such people, Kaposi sarcoma may recur after many years on HAART, especially if HIV is not completely suppressed. 699: 687: 314:
and most often affects only the legs. Endemic KS is most common in Sub-Saharan Africa and is more aggressive in children, while older adults present similarly to classic KS. Immunosuppression therapy-related KS generally occurs in people following
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Gill PS, Tulpule A, Espina BM, Cabriales S, Bresnahan J, Ilaw M, Louie S, Gustafson NF, Brown MA, Orcutt C, Winograd B, Scadden DT (June 1999). "Paclitaxel is safe and effective in the treatment of advanced AIDS-related Kaposi's sarcoma".
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or immunosuppression, treating the cause of the immune system dysfunction can slow or stop the progression of KS. In 40% or more of patients with AIDS-associated Kaposi sarcoma, the Kaposi lesions will shrink upon first starting
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and first described in 1981. This form of KS is over 300 times more common in AIDS patients than in renal transplant recipients. In this case, HHV 8 is sexually transmitted among people also at risk for sexually transmitted HIV
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Involvement can be common in those with transplant-related or AIDS-related KS, and it may occur in the absence of skin involvement. The gastrointestinal lesions may be silent or cause weight loss, pain, nausea/vomiting,
5667: 5652: 631:. The most typical feature of Kaposi sarcoma is the presence of spindle cells forming slits containing red blood cells. Mitotic activity is only moderate and pleomorphism is usually absent. The tumor is highly 3392: 575:
sexual lubricant might be a major mode for transmission. Prudent advice is to use commercial lubricants when needed and avoid deep kissing with partners with KSHV infection or whose status is unknown.
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Tappero JW, Berger TG, Kaplan LD, Volberding PA, Kahn JO (1991). "Cryotherapy for cutaneous Kaposi's sarcoma (KS) associated with acquired immune deficiency syndrome (AIDS): a phase II trial".
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Because of their highly visible nature, external lesions are sometimes the presenting symptom of AIDS. Kaposi sarcoma entered the awareness of the general public with the release of the film
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first described the cancer, the disease has been reported in five separate clinical settings, with different presentations, epidemiology, and prognoses. All of the forms are infected with
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Treatment is based on the sub-type, whether the condition is localized or widespread, and the person's immune function. Localized skin lesions may be treated by surgery, injections of
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KSHV is also transmissible via organ transplantation and blood transfusion. Testing for the virus before these procedures is likely to effectively limit iatrogenic transmission.
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and forms vascular channels that fill with blood cells, giving the tumor its characteristic bruise-like appearance. KSHV proteins are uniformly detected in KS cancer cells.
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The condition is relatively common in people with HIV/AIDS and following organ transplant. Over 35% of people with AIDS may be affected. KS was first described by
5682: 4815: 3113:"Propranolol Decreases Proliferation of Endothelial Cells Transformed by Kaposi's Sarcoma-Associated Herpesvirus and Induces Lytic Viral Gene Expression" 888:
presents with nodular, infiltrative, vascular masses on the extremities, mostly in men between the ages of 20 and 50, and is endemic in tropical Africa.
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Fenig E, Brenner B, Rakowsky E, Lapidoth M, Katz A, Sulkes A (October 1998). "Classic Kaposi sarcoma: experience at Rabin Medical Center in Israel".
635:, containing abnormally dense and irregular blood vessels, which leak red blood cells into the surrounding tissue and give the tumor its dark color. 2183:
Hladik W, Dollard SC, Mermin J, Fowlkes AL, Downing R, Amin MM, Banage F, Nzaro E, Kataaha P, Dondero TJ, Pellett PE, Lackritz EM (September 2006).
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Luppi M, Barozzi P, Schulz TF, Setti G, Staskus K, Trovato R, Narni F, Donelli A, Maiorana A, Marasca R, Sandrini S, Torelli G (November 2000).
349:(HAART) prevents and often treats KS. In certain cases the addition of chemotherapy may be required. With widespread disease, death may occur. 2073:. Manipulation of the immune response by Epstein-Barr virus and Kaposi's sarcoma-associated herpes virus: Consequences for tumor development. 705:
Micrograph of plaque stage, with bizarre vessels dissecting the upper dermis. There is erythrocyte extravasation and hemosiderin pigmentation.
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Sgadari C, Toschi E, Palladino C, Barillari G, Carlei D, Cereseto A, Ciccolella C, Yarchoan R, Monini P, Stürzl M, Ensoli B (July 2000).
2756:"Increasing Kaposi's sarcoma-associated herpesvirus seroprevalence with age in a highly Kaposi's sarcoma endemic region, Zambia in 1985" 2707:"Increasing Kaposi's sarcoma-associated herpesvirus seroprevalence with age in a highly Kaposi's sarcoma endemic region, Zambia in 1985" 5401: 5072: 547: 3278: 4473: 727:
Although KS may be suspected from the appearance of lesions and the patient's risk factors, a definite diagnosis can be made only by
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Micrograph of promontory sign in Kaposi's sarcoma in patch stage. Dilated irregular vascular channels surround a pre-existing vessel.
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Micrograph of tumor stage. Well-circumscribed spindle-cell tumor. Erythrocytes lie within poorly defined slit-like vascular spaces.
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Borkovic SP, Schwartz RA (December 1981). "Kaposi's sarcoma presenting in the homosexual man -- a new and striking phenomenon!".
2288:"Mesenchymal-to-endothelial transition in Kaposi sarcoma: a histogenetic hypothesis based on a case series and literature review" 1111: 958:
and, thus, there is little screening for persons at risk for becoming infected with KSHV, such as people following a transplant.
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is aggressive, occurring in children under 10 years of age, presenting with lymph node involvement, with or without skin lesions.
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and are different manifestations of the same disease but have differences in clinical aggressiveness, prognosis, and treatment.
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is more effective than either of those two therapies individually. Limited basic and clinical evidence suggest that topical
5603: 4551: 1064: 1090: 550:(KSHV), also called HHV-8, is present in almost 100% of Kaposi sarcoma lesions, whether HIV-related, classic, endemic, or 5693: 4801: 4635: 3974: 1586: 4726: 4544: 3875: 2475: 1565: 1130: 1408: 1097: 5003: 4578: 4523: 3984: 3361: 357: 478:
The mouth is involved in about 30% of cases, and is the initial site in 15% of AIDS-related KS. In the mouth, the
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of a Kaposi sarcoma showing the characteristic spindle cells, high vascularity, and intracellular hyaline globs.
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Ensoli B, Sirianni MC (1998). "Kaposi's sarcoma pathogenesis: a link between immunology and tumor biology".
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Garay SM, Belenko M, Fazzini E, Schinella R (January 1987). "Pulmonary manifestations of Kaposi's sarcoma".
539:, when the lesions are directly seen and often biopsied. Kaposi's sarcoma of the lung has a poor prognosis. 5623: 5569: 4561: 4303: 4058: 3749: 3679: 5809: 5613: 5504: 5249: 4983: 4793: 4721: 4053: 3584: 3539: 2803:
Qunibi W, Al-Furayh O, Almeshari K, Lin SF, Sun R, Heston L, Ross D, Rigsby M, Miller G (February 1998).
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Dezube BJ (October 1996). "Clinical presentation and natural history of AIDS--related Kaposi's sarcoma".
3299: 5303: 4993: 4988: 4931: 4406: 4126: 2805:"Serologic association of human herpesvirus eight with posttransplant Kaposi's sarcoma in Saudi Arabia" 2658:"The geographical distribution of Kaposi's sarcoma and of lymphomas in Africa before the AIDS epidemic" 2114:
Pauk J, Huang ML, Brodie SJ, Wald A, Koelle DM, Schacker T, Celum C, Selke S, Corey L (November 2000).
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People with a few local lesions can often be treated with local measures such as radiation therapy or
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Blumenfeld W, Egbert BM, Sagebiel RW (February 1985). "Differential diagnosis of Kaposi's sarcoma".
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Schwartz RA, Micali G, Nasca MR, Scuderi L (August 2008). "Kaposi sarcoma: a continuing conundrum".
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Kaposi sarcoma is not curable, but it can often be treatable for many years. In KS associated with
2571:"Classic Kaposi's sarcoma in Jews living in Israel, 1961-1989: a population-based incidence study" 5574: 5244: 4906: 4630: 4436: 4131: 3850: 3822: 3452: 1164:, where KSHV is widespread, KS has become the most frequently reported cancer in some countries. 1153: 1057: 1104: 4998: 4964: 4704: 4625: 4593: 4411: 4323: 3639: 1033:
AIDS-associated Kaposi sarcoma will again rise as these people live longer with HIV infection.
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They are typically found on the skin, but spread elsewhere is common, especially the mouth,
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Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS (December 1994).
387:. Growth can range from very slow to explosively fast, and is associated with significant 8: 5671: 5028: 4381: 4318: 4293: 4267: 4121: 4099: 3694: 3654: 3574: 2846:"Bone marrow failure associated with human herpesvirus 8 infection after transplantation" 1746: 1145: 398:
The lesions are painless, but become cosmetically disfiguring or interruptive to organs.
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Characteristic purple lesions of Kaposi's sarcoma on the nose of an HIV-positive female.
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positive hyaline bodies are often seen in the cytoplasm or sometimes extracellularly.
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Phillips AM, Jones AG, Osmond DH, Pollack LM, Catania JA, Martin JN (December 2008).
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Patch stage Kaposi's sarcoma. Red to brownish irregularly shaped macules and plaques.
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by the lesion). Kaposi's sarcoma skin lesions may be psychologically distressing.
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are nodules or blotches that may be red, purple, brown, or black, and are usually
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Cesarman E, Damania B, Krown SE, Martin J, Bower M, Whitby D (January 2019).
1157: 999: 873: 839: 823: 781: 500: 470:-positive person presenting with a Kaposi's sarcoma lesion with an overlying 353: 323: 199: 5661: 2546: 2529: 1676: 5543: 5375: 5298: 5288: 5235: 5195: 5186: 5034: 4782: 4777: 4712: 4490: 4451: 4361: 3933: 3913: 3728: 3723: 3713: 3554: 3341: 3264: 3223: 3187: 3146: 3097: 3048: 2871: 2555: 2425: 2331: 2210: 2141: 2100: 2051: 1827: 1812: 1532: 1486: 1390: 1330: 1218: 1021: 1007: 987: 983: 851: 838:
condition tends to be indolent and chronic, affecting elderly men from the
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and other vascular proliferations can be microscopically confused with KS.
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Sand M, Sand D, Thrandorf C, Paech V, Altmeyer P, Bechara FG (June 2010).
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that promote cancer cell proliferation and escape from the immune system.
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Iscovich J, Boffetta P, Winkelmann R, Brennan P, Azizi E (October 1998).
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Griffiths C, Barker J, Bleiker TO, Chalmers R, Creamer D (4 April 2016).
2201: 2184: 1828:"Psychosocial considerations in the therapy of epidemic Kaposi's sarcoma" 1011: 1003: 982:. Weak evidence suggests that antiretroviral therapy in combination with 979: 901: 617: 532: 479: 471: 447: 423: 286: 178: 2347:"Evidence for the origin of Kaposi's sarcoma from lymphatic endothelium" 876:
and is a more aggressive disease that infiltrates the skin extensively.
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Collins English Dictionary – Complete and Unabridged, 12th Edition 2014
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Laboratory Investigation; A Journal of Technical Methods and Pathology
1523: 1506: 430:. The lesions are usually as described above, but may occasionally be 5750: 5483: 5446: 5330: 4916: 4840: 4401: 4351: 4115: 3702: 3674: 3579: 3414: 3400: 614: 559: 555: 427: 392: 31: 2946: 1613: 1046: 5153: 5124: 5119: 5114: 4978: 4426: 4048: 4028: 3964: 3918: 3860: 3797: 3739: 3559: 3508: 3437: 3035:
Zimmerman EE, Crawford P (December 2012). "Cutaneous cryosurgery".
1652: 811: 496: 303: 227: 150: 1946:(June 1991). "Gastrointestinal malignancy in patients with AIDS". 5499: 5470: 5239: 5219: 5040: 4953: 4943: 4773: 4642: 4225: 4079: 3989: 3908: 3895: 3845: 3774: 3498: 3493: 3488: 2754:
Olsen SJ, Chang Y, Moore PS, Biggar RJ, Melbye M (October 1998).
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Olsen SJ, Chang Y, Moore PS, Biggar RJ, Melbye M (October 1998).
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Cook-Mozaffari P, Newton R, Beral V, Burkitt DP (December 1998).
2568: 2285: 991: 796: 598: 5698: 3159: 2655: 2530:"Classic Kaposi's sarcoma in Arabs--widening ethnic involvement" 2286:
Gurzu S, Ciortea D, Munteanu T, Kezdi-Zaharia I, Jung I (2008).
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around the tumor may produce swelling and pain. Variously sized
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Involvement of the airway can present with shortness of breath,
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in the 1980s. KSHV was discovered as a causative agent in 1994.
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Abdelmaksoud A, Filoni A, Giudice G, Vestita M (January 2017).
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and many parts of the body can be affected. KS is diagnosed by
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and mostly affects the skin. Epidemic KS occurs in people with
294: 290: 278: 162: 3064:"Treatment of Kaposi sarcoma in children with HIV-1 infection" 2465: 2016:
Ablashi DV, Chatlynne LG, Whitman JE, Cesarman E (July 2002).
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Cancer of the skin, integumentary lymph nodes, or other organs
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Beral V, Peterman TA, Berkelman RL, Jaffe HW (January 1990).
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Classic, endemic, immunosuppression therapy-related, epidemic
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and microscopic examination. Detection of the KSHV protein
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Drabell FG (2006). "Kaposi's Sarcoma and Renal Diseases".
2646: 2185:"Transmission of human herpesvirus 8 by blood transfusion" 2182: 1450: 1368: 1249:. S.v. "Kaposi's sarcoma." Retrieved August 15, 2017 from 1234:. S.v. "Kaposi's sarcoma." Retrieved August 15, 2017 from 2154: 1865:
França, Katlein; Jafferany, Mohammad (16 December 2016).
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The spindle cells of Kaposi sarcoma differentiate toward
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Despite its name, in general it is not considered a true
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had been described, but only rarely until the advent of
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Anglemyer A, Agrawal AK, Rutherford GW (January 2014).
2843: 1941: 1894:"Treating Kaposi's lesions in the HIV-infected patient" 627:
with a characteristic abnormal elongated shape, called
310:(HHV8 – also called KS-associated herpesvirus (KSHV)). 3239:"Mechanism of paclitaxel activity in Kaposi's sarcoma" 3110: 1650: 1504: 1180: 3111:
McAllister SC, Hanson RS, Manion RD (November 2015).
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Stress and Skin Disorders: Basic and Clinical Aspects
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http://www.thefreedictionary.com/Kaposi's+sarcoma
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http://www.thefreedictionary.com/Kaposi's+sarcoma
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In people with AIDS, Kaposi sarcoma is considered an
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HHV-8 is responsible for all varieties of KS. Since
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Andrews' Diseases of the Skin: Clinical Dermatology
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Random House Kernerman Webster's College Dictionary
356:in 1872. It became more widely known as one of the 326:, while the extent of disease may be determined by 117: 90: 61: 2223: 1891: 1557:Ferri's Clinical Advisor 2018 E-Book: 5 Books in 1 3401:Diseases of the skin and appendages by morphology 3034: 2698: 2501: 1892:Nichols CM, Flaitz CM, Hicks MJ (November 1993). 1614:"Idiopathisches multiples Pigmentsarkom der Haut" 593:of a Kaposi sarcoma showing its typical features. 5786: 2884: 2116:"Mucosal shedding of human herpesvirus 8 in men" 1294: 854:have a higher rate of KSHV/HHV-8 infection than 654:rather than blood vessel origin. The consistent 4695:Intravascular papillary endothelial hyperplasia 2994:Journal of Acquired Immune Deficiency Syndromes 2441:Archives of Pathology & Laboratory Medicine 1864: 923:that begin as one or several red to purple-red 609:of KS remains controversial. KS may arise as a 442:. Associated swelling may be from either local 25:Kaposi's sarcoma, multiple haemorrhagic sarcoma 3166:Journal of the American Academy of Dermatology 2497: 2495: 2493: 2491: 2489: 2487: 2345:Beckstead JH, Wood GS, Fletcher V (May 1985). 2250: 1371:Journal of the American Academy of Dermatology 5599:Asymmetric periflexural exanthem of childhood 4809: 4467: 3886:Pityriasis lichenoides et varioliformis acuta 3386: 1581: 1579: 1577: 662:supports the lymphatic nature of the lesion. 482:is most frequently affected, followed by the 4481: 3540:Dermatofibroma (benign fibrous histiocytoma) 2064: 2009: 1825: 1762: 1760: 1758: 1756: 1708:Hematology/Oncology Clinics of North America 3068:The Cochrane Database of Systematic Reviews 2534:Journal of Cancer Research and Therapeutics 2484: 1297:"Diagnosis and Treatment of Kaposi Sarcoma" 1272: 1270: 1268: 1266: 1264: 1262: 1260: 1258: 894:Immunosuppression-associated Kaposi sarcoma 5402:Papular purpuric gloves and socks syndrome 4816: 4802: 4474: 4460: 3393: 3379: 2065:Liang C, Lee JS, Jung JU (December 2008). 1898:Journal of the American Dental Association 1574: 1500: 1498: 1496: 1364: 1362: 1360: 750:Differential diagnosis of Kaposi's sarcoma 30: 3331: 3254: 3177: 3136: 3087: 2861: 2820: 2771: 2722: 2681: 2586: 2545: 2362: 2321: 2311: 2200: 2131: 2090: 2041: 1802: 1792: 1753: 1560:. Elsevier Health Sciences. p. 735. 1522: 1505:Hoffmann C, Sabranski M, Esser S (2017). 1476: 1402: 1400: 1358: 1356: 1354: 1352: 1350: 1348: 1346: 1344: 1342: 1340: 1320: 1208: 1198: 1131:Learn how and when to remove this message 489: 293:. The skin lesions are usually painless, 2279: 2224:Coffin JM, Hughes SH, Varmus HE (1997). 1948:The American Journal of Gastroenterology 1301:American Journal of Clinical Dermatology 1295:Schneider JW, Dittmer DP (August 2017). 1255: 585: 535:. The diagnosis is usually confirmed by 461: 413: 405: 5073:Kaposi's sarcoma-associated herpesvirus 3359:Kaposi sarcoma photo library at Dermnet 2929: 2388:Rosai and Ackerman's Surgical Pathology 1826:Holland, J. C.; Tross, S. (June 1987). 1547: 1493: 880:African lymphadenopathic Kaposi sarcoma 735:in tumor cells confirms the diagnosis. 548:Kaposi's sarcoma-associated herpesvirus 5787: 4753:Multifocal lymphangioendotheliomatosis 4193:Disseminated intravascular coagulation 2911: 1705: 1611: 1407:The Global Cancer Observatory (2019). 1397: 1337: 4797: 4455: 3374: 2620:American Journal of Clinical Oncology 2527: 2385: 1743:Taber's Cyclopedic Medical Dictionary 1553: 363: 5805:Connective and soft tissue neoplasms 5604:Post-vaccination follicular eruption 4552:Proliferating angioendotheliomatosis 3279:"Summary of Product Characteristics" 2502:James W, Berger T, Elston D (2005). 1618:Archiv für Dermatologie und Syphilis 1446: 1444: 1442: 1440: 1438: 1436: 1434: 1432: 1430: 1428: 1160:has been weakened. With the rise of 1069:adding citations to reliable sources 1040: 973:highly active antiretroviral therapy 510: 422:Commonly affected areas include the 347:highly active antiretroviral therapy 2850:The New England Journal of Medicine 2189:The New England Journal of Medicine 2120:The New England Journal of Medicine 13: 5800:Virus-related cutaneous conditions 5273: 4018: 3975:Postinflammatory hyperpigmentation 2934:. New York: Nova Biomedical Books. 919:typically presents with cutaneous 14: 5826: 4727:Acquired progressive lymphangioma 3876:Transient acantholytic dermatosis 3352: 2470:(Ninth ed.). p. 31.29. 2351:The American Journal of Pathology 1942:Danzig JB, Brandt LJ, Reinus JF, 1507:"HIV-Associated Kaposi's Sarcoma" 1425: 872:. This variant is not related to 817: 5619:Viral-associated trichodysplasia 5004:Modified varicella-like syndrome 4827:, symptoms and signs related to 3985:Idiopathic guttate hypomelanosis 3006:10.1097/00126334-199109000-00002 2822:10.1097/00007890-199802270-00024 2773:10.1097/00002030-199814000-00024 2724:10.1097/00002030-199814000-00024 2632:10.1097/00000421-199810000-00016 2588:10.1097/00002030-199815000-00019 1045: 886:African cutaneous Kaposi sarcoma 710: 698: 686: 667: 601:, which is a tumor arising from 86: 51: 5326:Epidermodysplasia verruciformis 4504:Blue rubber bleb nevus syndrome 3995:Hypopigmented mycosis fungoides 3271: 3230: 3194: 3153: 3104: 3055: 3028: 2985: 2938: 2923: 2917:Infections Causing Human Cancer 2905: 2878: 2837: 2796: 2747: 2611: 2562: 2521: 2459: 2432: 2404: 2379: 2338: 2253:Critical Reviews in Oncogenesis 2244: 2217: 2176: 2148: 2107: 2083:10.1016/j.semcancer.2008.09.003 2058: 1966: 1935: 1910:10.14219/jada.archive.1993.0231 1885: 1858: 1819: 1734: 1699: 1644: 1605: 1511:Oncology Research and Treatment 1457:Nature Reviews. Disease Primers 1183:"Cutaneous lesions of the nose" 1056:needs additional citations for 1027: 569: 216:Blue rubber bleb nevus syndrome 5341:Verrucae palmares et plantares 4236:Lichen sclerosis et atrophicus 3944:Subcorneal pustular dermatosis 3570:Infantile digital fibromatosis 3080:10.1002/14651858.CD009826.pub2 2468:Rook's textbook of dermatology 1288: 1240: 1225: 1174: 917:AIDS-associated Kaposi sarcoma 913:presentation is more variable. 410:An example of Kaposi's sarcoma 1: 5558:Hand, foot, and mouth disease 5053:Cytomegalic inclusion disease 3828:Epidermolysis bullosa simplex 3665:Langerhans cell histiocytosis 3312:Sexually Transmitted Diseases 2932:New Topics in Cancer Research 2265:10.1615/CritRevOncog.v9.i2.20 2034:10.1128/cmr.15.3.439-464.2002 2022:Clinical Microbiology Reviews 1720:10.1016/S0889-8588(05)70382-8 1167: 952: 5570:Foot-and-mouth disease virus 4599:Immunosuppression-associated 4562:Infantile hemangiopericytoma 4304:Systemic lupus erythematosus 4059:Systemic lupus erythematosus 3750:Systemic lupus erythematosus 3324:10.1097/OLQ.0b013e318182c91f 3204:Journal of Clinical Oncology 2963:10.1016/0140-6736(90)90001-L 2313:10.1371/journal.pone.0071530 1794:10.1371/journal.pone.0018397 961: 722: 581: 289:, in the mouth, or in other 281:that can form masses on the 7: 5614:Eruptive pseudoangiomatosis 5505:Congenital rubella syndrome 5250:Molluscum contagiosum virus 4722:Lymphangioma circumscriptum 3585:Lymphangioma circumscriptum 2863:10.1056/NEJM200011093431905 2506:(10th ed.). Saunders. 2133:10.1056/NEJM200011093431904 740:arteriovenous malformations 738:In differential diagnosis, 10: 5831: 4994:Disseminated herpes zoster 4932:Herpetic gingivostomatitis 4407:Mucous membrane pemphigoid 3256:10.4049/jimmunol.165.1.509 3216:10.1200/jco.1999.17.6.1876 3179:10.1016/j.jaad.2016.08.041 2915:(2006). "Rhadinoviruses". 2071:Seminars in Cancer Biology 1587:"Kaposi Sarcoma Treatment" 1383:10.1016/j.jaad.2008.05.001 1377:(2): 179–206, quiz 207–8. 1278:"Kaposi Sarcoma Treatment" 1036: 904:, which are inhibitors of 345:. In those with HIV/AIDS, 5730: 5638: 5591: 5541: 5516: 5481: 5454: 5445: 5412: 5373: 5349: 5262: 5228: 5205:Bovine papular stomatitis 5184: 5103: 5092: 5061: 5016: 4962: 4940: 4870: 4859: 4848: 4839: 4835: 4766: 4703: 4489: 4370: 4337: 4281: 4266: 4257: 4214: 4185: 4164: 4155: 4108: 4067: 4036: 4025: 4007: 3952: 3894: 3836: 3773: 3693: 3622: 3611: 3602: 3517: 3481: 3413: 3406: 3037:American Family Physician 2662:British Journal of Cancer 1871:. Springer. p. 216. 1591:National Cancer Institute 1469:10.1038/s41572-019-0060-9 1313:10.1007/s40257-017-0270-4 1282:National Cancer Institute 927:, rapidly progressing to 623:KS lesions contain tumor 426:, back, face, mouth, and 260: 252: 233: 209: 193: 177: 169: 156: 144: 43: 38: 29: 24: 5624:Gianotti–Crosti syndrome 5425:Merkel cell polyomavirus 5311:Laryngeal papillomatosis 4897:Herpes simplex keratitis 4741:Lymphangioleiomyomatosis 4584:African lymphadenopathic 4483:Tumours of blood vessels 4172:Thrombocytopenic purpura 3818:Dermatitis herpetiformis 3803:Acute contact dermatitis 3755:Pityriasis rubra pilaris 3680:Wiskott–Aldrich syndrome 3650:Lichen simplex chronicus 3530:Epidermal inclusion cyst 2390:(10th ed.). Mosby. 1187:Head & Face Medicine 542: 527:or chest pain, or as an 474:infection in their mouth 457: 256:42,000 (new cases, 2018) 5575:Boston exanthem disease 5245:Yaba monkey tumor virus 4927:Herpetiform esophagitis 4907:Neonatal herpes simplex 4437:Squamous-cell carcinoma 4432:Systemic histoplasmosis 3823:Porphyria cutanea tarda 3453:Squamous-cell carcinoma 2547:10.4103/0973-1482.80456 1677:10.1126/science.7997879 1154:opportunistic infection 401: 358:AIDS-defining illnesses 4999:Zoster-associated pain 4669:Universal angiomatosis 4636:Targeted hemosiderotic 4519:Endovascular papillary 4412:Cicatricial pemphigoid 4329:Acne keloidalis nuchae 4324:Folliculitis decalvans 2919:. Weinheim: Wiley-VCH. 898:calcineurin inhibitors 835:Classic Kaposi sarcoma 802:Bacillary angiomatosis 594: 505:intestinal obstruction 490:Gastrointestinal tract 475: 450:(obstruction of local 419: 411: 381:gastrointestinal tract 211:Differential diagnosis 5431:Merkel cell carcinoma 5354:Bovine papillomavirus 4314:Loose anagen syndrome 4241:Necrobiosis lipoidica 4177:Actinic/solar purpura 3851:Insect bite reactions 3640:Seborrheic dermatitis 3463:Merkel-cell carcinoma 3443:Molluscum contagiosum 3243:Journal of Immunology 1987:10.1378/chest.91.1.39 1749:. 2009. p. 1256. 1200:10.1186/1746-160X-6-7 589: 465: 417: 409: 316:organ transplantation 5773:Kaposi's sarcoma 5528:Alphavirus infection 5392:Erythema infectiosum 5169:Progressive vaccinia 5159:Generalized vaccinia 4984:Herpes zoster oticus 4509:Hemangioendothelioma 4137:Annulare centrifugum 3660:Glucagonoma syndrome 3458:Basal-cell carcinoma 3433:Seborrheic keratosis 3129:10.1128/JVI.01569-15 2674:10.1038/bjc.1998.717 2202:10.1056/NEJMoa055009 1838:(2 Suppl 3): 48–53. 1832:Seminars in Oncology 1741:"Kaposi's Sarcoma". 1065:improve this article 868:, mainly those from 787:Pneumocystis lesions 337:into the lesion, or 298:by a combination of 188:poor immune function 165:colored skin lesions 5029:Human herpesvirus 6 4382:Aphthous stomatitis 4319:Lichen planopilaris 4294:Androgenic alopecia 4100:Fixed drug eruption 3675:Pemphigus foliaceus 3575:Granular cell tumor 3117:Journal of Virology 2304:2013PLoSO...871530G 1785:2011PLoSO...618397J 1747:F. A. Davis Company 1669:1994Sci...266.1865C 1663:(5192): 1865–1869. 1002:(such as liposomal 308:Human herpesvirus 8 306:) and infection by 184:Human herpesvirus 8 5810:Vascular neoplasia 5731:External resources 5507:("German measles") 5321:Bowenoid papulosis 4892:Herpes gladiatorum 4690:Pyogenic granuloma 4557:Hemangiopericytoma 4402:Pemphigus vulgaris 4231:Granuloma annulare 4095:Carcinoid syndrome 3980:Tuberous sclerosis 3939:Coccidioidomycosis 3813:Bullous pemphigoid 3808:Pemphigus vulgaris 3740:Secondary syphilis 3630:Contact dermatitis 3364:2010-11-08 at the 1630:10.1007/BF01830024 1162:HIV/AIDS in Africa 1080:"Kaposi's sarcoma" 870:sub-Saharan Africa 807:Pyogenic granuloma 744:pyogenic granuloma 603:mesenchymal tissue 595: 529:incidental finding 476: 420: 412: 364:Signs and symptoms 300:immune suppression 220:pyogenic granuloma 5782: 5781: 5632: 5631: 5587: 5586: 5583: 5582: 5553:Coxsackie A virus 5533:Chikungunya fever 5441: 5440: 5397:Reticulocytopenia 5369: 5368: 5258: 5257: 5164:Eczema vaccinatum 5088: 5087: 5041:Exanthema subitum 5012: 5011: 4989:Ophthalmic zoster 4954:B virus infection 4922:Eczema herpeticum 4791: 4790: 4758:Lymphangiomatosis 4717:lymphangiosarcoma 4579:African cutaneous 4449: 4448: 4445: 4444: 4289:Telogen effluvium 4253: 4252: 4249: 4248: 4210: 4209: 4206: 4205: 4151: 4150: 4003: 4002: 3871:Lichen spinulosus 3866:Keratosis pilaris 3745:Mycosis fungoides 3645:Stasis dermatitis 3635:Atopic dermatitis 3598: 3597: 3473:Trichoepithelioma 3448:Actinic keratosis 2513:978-0-7216-2921-6 2397:978-0-8089-2433-3 2237:978-0-87969-571-2 1878:978-3-319-46352-0 1612:Kaposi M (1872). 1554:Ferri FF (2017). 1524:10.1159/000455971 1141: 1140: 1133: 1115: 998:alpha, liposomal 648:endothelial cells 525:coughing up blood 511:Respiratory tract 452:lymphatic vessels 440:fungating lesions 385:respiratory tract 339:radiation therapy 268: 267: 243:radiation therapy 195:Diagnostic method 19:Medical condition 5822: 5636: 5635: 5452: 5451: 5278: 5271: 5270: 5265:Papillomaviridae 5101: 5100: 5078:Kaposi's sarcoma 5046:Roseola vaccinia 4967: 4947: 4902:Herpetic sycosis 4887:Herpetic whitlow 4875: 4868: 4867: 4857: 4856: 4846: 4845: 4837: 4836: 4818: 4811: 4804: 4795: 4794: 4606:Hemangioblastoma 4574:Kaposi's sarcoma 4476: 4469: 4462: 4453: 4452: 4387:Oral candidiasis 4264: 4263: 4162: 4161: 4090:Erythema nodosum 4034: 4033: 4023: 4022: 4016: 4015: 3960:Tinea versicolor 3798:Bullous impetigo 3735:Pityriasis rosea 3670:Lichen sclerosus 3655:Darier's disease 3620: 3619: 3609: 3608: 3565:Kaposi's sarcoma 3411: 3410: 3395: 3388: 3381: 3372: 3371: 3346: 3345: 3335: 3303: 3297: 3296: 3294: 3292: 3283: 3275: 3269: 3268: 3258: 3234: 3228: 3227: 3198: 3192: 3191: 3181: 3157: 3151: 3150: 3140: 3108: 3102: 3101: 3091: 3059: 3053: 3052: 3032: 3026: 3025: 2989: 2983: 2982: 2942: 2936: 2935: 2927: 2921: 2920: 2909: 2903: 2902: 2887:Arizona Medicine 2882: 2876: 2875: 2865: 2841: 2835: 2834: 2824: 2800: 2794: 2793: 2775: 2751: 2745: 2744: 2726: 2702: 2696: 2695: 2685: 2653: 2644: 2643: 2615: 2609: 2608: 2590: 2566: 2560: 2559: 2549: 2528:Kumar P (2011). 2525: 2519: 2517: 2499: 2482: 2481: 2463: 2457: 2456: 2436: 2430: 2429: 2408: 2402: 2401: 2386:Rosai J (2011). 2383: 2377: 2376: 2366: 2342: 2336: 2335: 2325: 2315: 2283: 2277: 2276: 2248: 2242: 2241: 2221: 2215: 2214: 2204: 2180: 2174: 2173: 2152: 2146: 2145: 2135: 2111: 2105: 2104: 2094: 2062: 2056: 2055: 2045: 2013: 2007: 2006: 1970: 1964: 1963: 1939: 1933: 1932: 1930: 1929: 1920:. Archived from 1889: 1883: 1882: 1862: 1856: 1855: 1823: 1817: 1816: 1806: 1796: 1764: 1751: 1750: 1745:. Vol. 21. 1738: 1732: 1731: 1703: 1697: 1696: 1648: 1642: 1641: 1609: 1603: 1602: 1600: 1598: 1593:. 1 October 2015 1583: 1572: 1571: 1551: 1545: 1544: 1526: 1502: 1491: 1490: 1480: 1453:"Kaposi sarcoma" 1448: 1423: 1422: 1420: 1418: 1413: 1409:"Kaposi sarcoma" 1404: 1395: 1394: 1366: 1335: 1334: 1324: 1292: 1286: 1285: 1274: 1253: 1244: 1238: 1229: 1223: 1222: 1212: 1202: 1178: 1136: 1129: 1125: 1122: 1116: 1114: 1073: 1049: 1041: 968:immunodeficiency 941:mucous membranes 856:European peoples 848:Eastern European 714: 702: 690: 671: 656:immunoreactivity 343:biologic therapy 302:(such as due to 271:Kaposi's sarcoma 247:biologic therapy 224:melanocytic nevi 136: 135: 132: 131: 128: 125: 122: 119: 114: 113: 110: 107: 104: 101: 98: 95: 92: 83: 82: 79: 78: 75: 72: 69: 66: 63: 60: 57: 34: 22: 21: 5830: 5829: 5825: 5824: 5823: 5821: 5820: 5819: 5785: 5784: 5783: 5778: 5777: 5726: 5725: 5647: 5633: 5628: 5609:Lipschütz ulcer 5579: 5537: 5512: 5477: 5457:Paramyxoviridae 5437: 5408: 5365: 5345: 5274: 5254: 5224: 5200:Milker's nodule 5180: 5132:Monkeypox virus 5084: 5057: 5008: 4963: 4958: 4941: 4936: 4871: 4831: 4825:Skin infections 4822: 4792: 4787: 4762: 4699: 4589:AIDS-associated 4499:Hemangiosarcoma 4485: 4480: 4450: 4441: 4373: 4366: 4333: 4299:Alopecia areata 4277: 4259: 4245: 4202: 4181: 4157: 4147: 4104: 4063: 4049:Viral exanthems 4027: 4011: 4009: 3999: 3970:Pityriasis alba 3948: 3890: 3832: 3769: 3689: 3685:Zinc deficiency 3615: 3613: 3594: 3522: 3513: 3477: 3468:Nevus sebaceous 3402: 3399: 3366:Wayback Machine 3355: 3350: 3349: 3304: 3300: 3290: 3288: 3281: 3277: 3276: 3272: 3235: 3231: 3199: 3195: 3158: 3154: 3123:(21): 11144–9. 3109: 3105: 3074:(1): CD009826. 3060: 3056: 3043:(12): 1118–24. 3033: 3029: 2990: 2986: 2957:(8682): 123–8. 2943: 2939: 2928: 2924: 2910: 2906: 2883: 2879: 2856:(19): 1378–85. 2842: 2838: 2809:Transplantation 2801: 2797: 2752: 2748: 2703: 2699: 2654: 2647: 2616: 2612: 2581:(15): 2067–72. 2567: 2563: 2526: 2522: 2514: 2500: 2485: 2478: 2464: 2460: 2437: 2433: 2409: 2405: 2398: 2384: 2380: 2343: 2339: 2284: 2280: 2249: 2245: 2238: 2222: 2218: 2181: 2177: 2153: 2149: 2126:(19): 1369–77. 2112: 2108: 2063: 2059: 2014: 2010: 1971: 1967: 1940: 1936: 1927: 1925: 1890: 1886: 1879: 1863: 1859: 1824: 1820: 1765: 1754: 1740: 1739: 1735: 1704: 1700: 1649: 1645: 1610: 1606: 1596: 1594: 1585: 1584: 1575: 1568: 1552: 1548: 1503: 1494: 1449: 1426: 1416: 1414: 1411: 1405: 1398: 1367: 1338: 1293: 1289: 1284:. 16 June 2017. 1276: 1275: 1256: 1245: 1241: 1230: 1226: 1179: 1175: 1170: 1137: 1126: 1120: 1117: 1074: 1072: 1062: 1050: 1039: 1030: 964: 955: 866:African peoples 820: 792:Dermatophytosis 752: 725: 718: 715: 706: 703: 694: 691: 682: 672: 584: 572: 554:. KSHV encodes 545: 513: 492: 460: 438:with resulting 404: 366: 328:medical imaging 277:) is a type of 204:medical imaging 140: 116: 89: 85: 54: 50: 20: 17: 12: 11: 5: 5828: 5818: 5817: 5812: 5807: 5802: 5797: 5780: 5779: 5776: 5775: 5764: 5747: 5735: 5734: 5732: 5728: 5727: 5724: 5723: 5712: 5701: 5690: 5679: 5664: 5648: 5643: 5642: 5640: 5639:Classification 5630: 5629: 5627: 5626: 5621: 5616: 5611: 5606: 5601: 5595: 5593: 5589: 5588: 5585: 5584: 5581: 5580: 5578: 5577: 5572: 5567: 5566: 5565: 5560: 5549: 5547: 5544:Picornaviridae 5539: 5538: 5536: 5535: 5530: 5524: 5522: 5514: 5513: 5511: 5510: 5509: 5508: 5502: 5489: 5487: 5479: 5478: 5476: 5475: 5474: 5473: 5462: 5460: 5449: 5443: 5442: 5439: 5438: 5436: 5435: 5434: 5433: 5420: 5418: 5415:Polyomaviridae 5410: 5409: 5407: 5406: 5405: 5404: 5399: 5394: 5386:Parvovirus B19 5381: 5379: 5371: 5370: 5367: 5366: 5364: 5363: 5362: 5361: 5359:Equine sarcoid 5350: 5347: 5346: 5344: 5343: 5338: 5336:Pigmented wart 5333: 5328: 5323: 5318: 5316:Butcher's wart 5313: 5308: 5307: 5306: 5296: 5294:Heck's disease 5291: 5281: 5279: 5268: 5260: 5259: 5256: 5255: 5253: 5252: 5247: 5242: 5232: 5230: 5226: 5225: 5223: 5222: 5217: 5212: 5207: 5202: 5192: 5190: 5182: 5181: 5179: 5178: 5173: 5172: 5171: 5166: 5161: 5156: 5149:Vaccinia virus 5146: 5141: 5140: 5139: 5129: 5128: 5127: 5122: 5111: 5109: 5098: 5090: 5089: 5086: 5085: 5083: 5082: 5081: 5080: 5069: 5067: 5059: 5058: 5056: 5055: 5050: 5049: 5048: 5043: 5024: 5022: 5014: 5013: 5010: 5009: 5007: 5006: 5001: 4996: 4991: 4986: 4981: 4976: 4970: 4968: 4960: 4959: 4957: 4956: 4950: 4948: 4938: 4937: 4935: 4934: 4929: 4924: 4919: 4914: 4912:Genital herpes 4909: 4904: 4899: 4894: 4889: 4884: 4882:Herpes simplex 4878: 4876: 4865: 4854: 4843: 4833: 4832: 4821: 4820: 4813: 4806: 4798: 4789: 4788: 4786: 4785: 4780: 4770: 4768: 4764: 4763: 4761: 4760: 4755: 4750: 4748:Cystic hygroma 4745: 4744: 4743: 4731: 4730: 4729: 4724: 4709: 4707: 4701: 4700: 4698: 4697: 4692: 4687: 4686: 4685: 4680: 4670: 4667: 4666: 4665: 4660: 4655: 4650: 4640: 4639: 4638: 4633: 4628: 4623: 4618: 4608: 4603: 4602: 4601: 4596: 4591: 4586: 4581: 4571: 4566: 4565: 4564: 4554: 4549: 4548: 4547: 4542: 4536: 4531: 4526: 4521: 4516: 4506: 4501: 4495: 4493: 4487: 4486: 4479: 4478: 4471: 4464: 4456: 4447: 4446: 4443: 4442: 4440: 4439: 4434: 4429: 4424: 4422:Coxsackievirus 4419: 4414: 4409: 4404: 4399: 4394: 4389: 4384: 4378: 4376: 4368: 4367: 4365: 4364: 4359: 4354: 4349: 4343: 4341: 4335: 4334: 4332: 4331: 4326: 4321: 4316: 4311: 4306: 4301: 4296: 4291: 4285: 4283: 4279: 4278: 4276: 4275: 4272: 4270: 4261: 4255: 4254: 4251: 4250: 4247: 4246: 4244: 4243: 4238: 4233: 4228: 4218: 4216: 4212: 4211: 4208: 4207: 4204: 4203: 4201: 4200: 4195: 4189: 4187: 4183: 4182: 4180: 4179: 4174: 4168: 4166: 4159: 4153: 4152: 4149: 4148: 4146: 4145: 4139: 4134: 4132:Gyratum repens 4129: 4124: 4118: 4112: 4110: 4106: 4105: 4103: 4102: 4097: 4092: 4087: 4082: 4077: 4071: 4069: 4065: 4064: 4062: 4061: 4056: 4054:Toxic erythema 4051: 4046: 4044:Drug eruptions 4040: 4038: 4031: 4020: 4013: 4005: 4004: 4001: 4000: 3998: 3997: 3992: 3987: 3982: 3977: 3972: 3967: 3962: 3956: 3954: 3950: 3949: 3947: 3946: 3941: 3936: 3931: 3926: 3921: 3916: 3911: 3906: 3900: 3898: 3892: 3891: 3889: 3888: 3883: 3881:Lichen nitidus 3878: 3873: 3868: 3863: 3858: 3853: 3848: 3842: 3840: 3834: 3833: 3831: 3830: 3825: 3820: 3815: 3810: 3805: 3800: 3795: 3790: 3785: 3783:Herpes simplex 3779: 3777: 3771: 3770: 3768: 3767: 3762: 3757: 3752: 3747: 3742: 3737: 3732: 3726: 3721: 3716: 3711: 3705: 3699: 3697: 3691: 3690: 3688: 3687: 3682: 3677: 3672: 3667: 3662: 3657: 3652: 3647: 3642: 3637: 3632: 3626: 3624: 3617: 3606: 3600: 3599: 3596: 3595: 3593: 3592: 3587: 3582: 3577: 3572: 3567: 3562: 3557: 3552: 3547: 3542: 3537: 3532: 3526: 3524: 3515: 3514: 3512: 3511: 3506: 3501: 3496: 3491: 3485: 3483: 3479: 3478: 3476: 3475: 3470: 3465: 3460: 3455: 3450: 3445: 3440: 3435: 3430: 3425: 3419: 3417: 3408: 3404: 3403: 3398: 3397: 3390: 3383: 3375: 3369: 3368: 3354: 3353:External links 3351: 3348: 3347: 3318:(12): 1011–4. 3298: 3270: 3229: 3210:(6): 1876–83. 3193: 3172:(1): 153–155. 3152: 3103: 3054: 3027: 2984: 2937: 2922: 2904: 2877: 2836: 2795: 2766:(14): 1921–5. 2746: 2717:(14): 1921–5. 2697: 2668:(11): 1521–8. 2645: 2626:(5): 498–500. 2610: 2561: 2520: 2512: 2483: 2476: 2458: 2447:(2): 123–127. 2431: 2420:(2): 243–251. 2403: 2396: 2378: 2357:(2): 294–300. 2337: 2278: 2243: 2236: 2216: 2195:(13): 1331–8. 2175: 2147: 2106: 2077:(6): 423–436. 2057: 2028:(3): 439–464. 2008: 1965: 1934: 1884: 1877: 1857: 1818: 1752: 1733: 1698: 1643: 1624:(2): 265–273. 1604: 1573: 1566: 1546: 1492: 1424: 1396: 1336: 1307:(4): 529–539. 1287: 1254: 1239: 1224: 1172: 1171: 1169: 1166: 1139: 1138: 1053: 1051: 1044: 1038: 1035: 1029: 1026: 1000:anthracyclines 963: 960: 954: 951: 950: 949: 914: 908:function) for 891: 890: 889: 883: 859: 844:Arab countries 819: 818:Classification 816: 815: 814: 809: 804: 799: 794: 789: 784: 779: 777:Histoplasmosis 774: 772:Cryptococcosis 769: 764: 751: 748: 724: 721: 720: 719: 716: 709: 707: 704: 697: 695: 692: 685: 683: 673: 666: 650:, probably of 583: 580: 571: 568: 544: 541: 512: 509: 491: 488: 459: 456: 436:skin breakdown 403: 400: 365: 362: 266: 265: 262: 258: 257: 254: 250: 249: 235: 231: 230: 213: 207: 206: 197: 191: 190: 181: 175: 174: 171: 167: 166: 160: 154: 153: 148: 142: 141: 139: 138: 47: 45: 41: 40: 36: 35: 27: 26: 18: 15: 9: 6: 4: 3: 2: 5827: 5816: 5813: 5811: 5808: 5806: 5803: 5801: 5798: 5796: 5793: 5792: 5790: 5774: 5770: 5769: 5765: 5763: 5760: 5757: 5753: 5752: 5748: 5746: 5742: 5741: 5737: 5736: 5733: 5729: 5722: 5718: 5717: 5713: 5711: 5707: 5706: 5702: 5700: 5696: 5695: 5691: 5689: 5685: 5684: 5680: 5678: 5674: 5673: 5669: 5665: 5663: 5659: 5658: 5654: 5650: 5649: 5646: 5641: 5637: 5625: 5622: 5620: 5617: 5615: 5612: 5610: 5607: 5605: 5602: 5600: 5597: 5596: 5594: 5590: 5576: 5573: 5571: 5568: 5564: 5561: 5559: 5556: 5555: 5554: 5551: 5550: 5548: 5546: 5545: 5540: 5534: 5531: 5529: 5526: 5525: 5523: 5521: 5520: 5515: 5506: 5503: 5501: 5498: 5497: 5496: 5495: 5494:Rubella virus 5491: 5490: 5488: 5486: 5485: 5484:Matonaviridae 5480: 5472: 5469: 5468: 5467: 5464: 5463: 5461: 5459: 5458: 5453: 5450: 5448: 5444: 5432: 5429: 5428: 5427: 5426: 5422: 5421: 5419: 5417: 5416: 5411: 5403: 5400: 5398: 5395: 5393: 5390: 5389: 5388: 5387: 5383: 5382: 5380: 5378: 5377: 5372: 5360: 5357: 5356: 5355: 5352: 5351: 5348: 5342: 5339: 5337: 5334: 5332: 5331:Verruca plana 5329: 5327: 5324: 5322: 5319: 5317: 5314: 5312: 5309: 5305: 5302: 5301: 5300: 5297: 5295: 5292: 5290: 5286: 5283: 5282: 5280: 5277: 5272: 5269: 5267: 5266: 5261: 5251: 5248: 5246: 5243: 5241: 5237: 5234: 5233: 5231: 5227: 5221: 5218: 5216: 5213: 5211: 5208: 5206: 5203: 5201: 5197: 5194: 5193: 5191: 5189: 5188: 5183: 5177: 5174: 5170: 5167: 5165: 5162: 5160: 5157: 5155: 5152: 5151: 5150: 5147: 5145: 5142: 5138: 5135: 5134: 5133: 5130: 5126: 5123: 5121: 5118: 5117: 5116: 5113: 5112: 5110: 5108: 5107: 5102: 5099: 5097: 5096: 5091: 5079: 5076: 5075: 5074: 5071: 5070: 5068: 5066: 5065: 5060: 5054: 5051: 5047: 5044: 5042: 5039: 5038: 5037: 5036: 5031: 5030: 5026: 5025: 5023: 5021: 5020: 5015: 5005: 5002: 5000: 4997: 4995: 4992: 4990: 4987: 4985: 4982: 4980: 4979:Herpes zoster 4977: 4975: 4972: 4971: 4969: 4966: 4961: 4955: 4952: 4951: 4949: 4946: 4945: 4939: 4933: 4930: 4928: 4925: 4923: 4920: 4918: 4915: 4913: 4910: 4908: 4905: 4903: 4900: 4898: 4895: 4893: 4890: 4888: 4885: 4883: 4880: 4879: 4877: 4874: 4869: 4866: 4864: 4863: 4858: 4855: 4853: 4852: 4851:Herpesviridae 4847: 4844: 4842: 4838: 4834: 4830: 4826: 4819: 4814: 4812: 4807: 4805: 4800: 4799: 4796: 4784: 4781: 4779: 4775: 4772: 4771: 4769: 4765: 4759: 4756: 4754: 4751: 4749: 4746: 4742: 4739: 4738: 4737: 4736: 4732: 4728: 4725: 4723: 4720: 4719: 4718: 4714: 4711: 4710: 4708: 4706: 4702: 4696: 4693: 4691: 4688: 4684: 4681: 4679: 4676: 4675: 4674: 4673:Angiokeratoma 4671: 4668: 4664: 4661: 4659: 4656: 4654: 4651: 4649: 4646: 4645: 4644: 4641: 4637: 4634: 4632: 4629: 4627: 4624: 4622: 4619: 4617: 4614: 4613: 4612: 4609: 4607: 4604: 4600: 4597: 4595: 4592: 4590: 4587: 4585: 4582: 4580: 4577: 4576: 4575: 4572: 4570: 4567: 4563: 4560: 4559: 4558: 4555: 4553: 4550: 4546: 4543: 4540: 4537: 4535: 4532: 4530: 4527: 4525: 4522: 4520: 4517: 4515: 4512: 4511: 4510: 4507: 4505: 4502: 4500: 4497: 4496: 4494: 4492: 4488: 4484: 4477: 4472: 4470: 4465: 4463: 4458: 4457: 4454: 4438: 4435: 4433: 4430: 4428: 4425: 4423: 4420: 4418: 4415: 4413: 4410: 4408: 4405: 4403: 4400: 4398: 4395: 4393: 4392:Lichen planus 4390: 4388: 4385: 4383: 4380: 4379: 4377: 4375: 4369: 4363: 4360: 4358: 4355: 4353: 4350: 4348: 4347:Onychomycosis 4345: 4344: 4342: 4340: 4336: 4330: 4327: 4325: 4322: 4320: 4317: 4315: 4312: 4310: 4309:Tinea capitis 4307: 4305: 4302: 4300: 4297: 4295: 4292: 4290: 4287: 4286: 4284: 4280: 4274: 4273: 4271: 4269: 4265: 4262: 4258:Miscellaneous 4256: 4242: 4239: 4237: 4234: 4232: 4229: 4227: 4223: 4220: 4219: 4217: 4213: 4199: 4196: 4194: 4191: 4190: 4188: 4184: 4178: 4175: 4173: 4170: 4169: 4167: 4163: 4160: 4156:Nonblanchable 4154: 4143: 4140: 4138: 4135: 4133: 4130: 4128: 4125: 4123: 4119: 4117: 4114: 4113: 4111: 4107: 4101: 4098: 4096: 4093: 4091: 4088: 4086: 4083: 4081: 4078: 4076: 4073: 4072: 4070: 4066: 4060: 4057: 4055: 4052: 4050: 4047: 4045: 4042: 4041: 4039: 4035: 4032: 4030: 4024: 4021: 4017: 4014: 4006: 3996: 3993: 3991: 3988: 3986: 3983: 3981: 3978: 3976: 3973: 3971: 3968: 3966: 3963: 3961: 3958: 3957: 3955: 3953:Hypopigmented 3951: 3945: 3942: 3940: 3937: 3935: 3932: 3930: 3927: 3925: 3922: 3920: 3917: 3915: 3912: 3910: 3907: 3905: 3904:Acne vulgaris 3902: 3901: 3899: 3897: 3893: 3887: 3884: 3882: 3879: 3877: 3874: 3872: 3869: 3867: 3864: 3862: 3859: 3857: 3856:Lichen planus 3854: 3852: 3849: 3847: 3844: 3843: 3841: 3839: 3835: 3829: 3826: 3824: 3821: 3819: 3816: 3814: 3811: 3809: 3806: 3804: 3801: 3799: 3796: 3794: 3791: 3789: 3788:Herpes zoster 3786: 3784: 3781: 3780: 3778: 3776: 3772: 3766: 3763: 3761: 3760:Parapsoriasis 3758: 3756: 3753: 3751: 3748: 3746: 3743: 3741: 3738: 3736: 3733: 3730: 3727: 3725: 3722: 3720: 3717: 3715: 3712: 3710: 3706: 3704: 3701: 3700: 3698: 3696: 3692: 3686: 3683: 3681: 3678: 3676: 3673: 3671: 3668: 3666: 3663: 3661: 3658: 3656: 3653: 3651: 3648: 3646: 3643: 3641: 3638: 3636: 3633: 3631: 3628: 3627: 3625: 3621: 3618: 3610: 3607: 3605: 3601: 3591: 3588: 3586: 3583: 3581: 3578: 3576: 3573: 3571: 3568: 3566: 3563: 3561: 3558: 3556: 3553: 3551: 3548: 3546: 3543: 3541: 3538: 3536: 3533: 3531: 3528: 3527: 3525: 3520: 3516: 3510: 3507: 3505: 3502: 3500: 3497: 3495: 3492: 3490: 3487: 3486: 3484: 3480: 3474: 3471: 3469: 3466: 3464: 3461: 3459: 3456: 3454: 3451: 3449: 3446: 3444: 3441: 3439: 3436: 3434: 3431: 3429: 3426: 3424: 3421: 3420: 3418: 3416: 3412: 3409: 3405: 3396: 3391: 3389: 3384: 3382: 3377: 3376: 3373: 3367: 3363: 3360: 3357: 3356: 3343: 3339: 3334: 3329: 3325: 3321: 3317: 3313: 3309: 3302: 3287: 3280: 3274: 3266: 3262: 3257: 3252: 3249:(1): 509–17. 3248: 3244: 3240: 3233: 3225: 3221: 3217: 3213: 3209: 3205: 3197: 3189: 3185: 3180: 3175: 3171: 3167: 3163: 3156: 3148: 3144: 3139: 3134: 3130: 3126: 3122: 3118: 3114: 3107: 3099: 3095: 3090: 3085: 3081: 3077: 3073: 3069: 3065: 3058: 3050: 3046: 3042: 3038: 3031: 3023: 3019: 3015: 3011: 3007: 3003: 3000:(9): 839–46. 2999: 2995: 2988: 2980: 2976: 2972: 2968: 2964: 2960: 2956: 2952: 2948: 2941: 2933: 2926: 2918: 2914: 2908: 2900: 2896: 2893:(12): 902–4. 2892: 2888: 2881: 2873: 2869: 2864: 2859: 2855: 2851: 2847: 2840: 2832: 2828: 2823: 2818: 2814: 2810: 2806: 2799: 2791: 2787: 2783: 2779: 2774: 2769: 2765: 2761: 2757: 2750: 2742: 2738: 2734: 2730: 2725: 2720: 2716: 2712: 2708: 2701: 2693: 2689: 2684: 2679: 2675: 2671: 2667: 2663: 2659: 2652: 2650: 2641: 2637: 2633: 2629: 2625: 2621: 2614: 2606: 2602: 2598: 2594: 2589: 2584: 2580: 2576: 2572: 2565: 2557: 2553: 2548: 2543: 2539: 2535: 2531: 2524: 2515: 2509: 2505: 2498: 2496: 2494: 2492: 2490: 2488: 2479: 2477:9781118441190 2473: 2469: 2462: 2454: 2450: 2446: 2442: 2435: 2427: 2423: 2419: 2415: 2407: 2399: 2393: 2389: 2382: 2374: 2370: 2365: 2360: 2356: 2352: 2348: 2341: 2333: 2329: 2324: 2319: 2314: 2309: 2305: 2301: 2298:(8): e71530. 2297: 2293: 2289: 2282: 2274: 2270: 2266: 2262: 2259:(2): 107–24. 2258: 2254: 2247: 2239: 2233: 2229: 2228: 2220: 2212: 2208: 2203: 2198: 2194: 2190: 2186: 2179: 2171: 2167: 2164:(7): 2826–9. 2163: 2159: 2151: 2143: 2139: 2134: 2129: 2125: 2121: 2117: 2110: 2102: 2098: 2093: 2088: 2084: 2080: 2076: 2072: 2068: 2061: 2053: 2049: 2044: 2039: 2035: 2031: 2027: 2023: 2019: 2012: 2004: 2000: 1996: 1992: 1988: 1984: 1980: 1976: 1969: 1961: 1957: 1953: 1949: 1945: 1938: 1924:on 2007-09-29 1923: 1919: 1915: 1911: 1907: 1904:(11): 78–84. 1903: 1899: 1895: 1888: 1880: 1874: 1870: 1869: 1861: 1853: 1849: 1845: 1841: 1837: 1833: 1829: 1822: 1814: 1810: 1805: 1800: 1795: 1790: 1786: 1782: 1779:(4): e18397. 1778: 1774: 1770: 1763: 1761: 1759: 1757: 1748: 1744: 1737: 1729: 1725: 1721: 1717: 1714:(5): 1023–9. 1713: 1709: 1702: 1694: 1690: 1686: 1682: 1678: 1674: 1670: 1666: 1662: 1658: 1654: 1647: 1639: 1635: 1631: 1627: 1623: 1619: 1615: 1608: 1592: 1588: 1582: 1580: 1578: 1569: 1567:9780323529570 1563: 1559: 1558: 1550: 1542: 1538: 1534: 1530: 1525: 1520: 1516: 1512: 1508: 1501: 1499: 1497: 1488: 1484: 1479: 1474: 1470: 1466: 1462: 1458: 1454: 1447: 1445: 1443: 1441: 1439: 1437: 1435: 1433: 1431: 1429: 1410: 1403: 1401: 1392: 1388: 1384: 1380: 1376: 1372: 1365: 1363: 1361: 1359: 1357: 1355: 1353: 1351: 1349: 1347: 1345: 1343: 1341: 1332: 1328: 1323: 1318: 1314: 1310: 1306: 1302: 1298: 1291: 1283: 1279: 1273: 1271: 1269: 1267: 1265: 1263: 1261: 1259: 1252: 1248: 1243: 1237: 1233: 1228: 1220: 1216: 1211: 1206: 1201: 1196: 1192: 1188: 1184: 1177: 1173: 1165: 1163: 1159: 1158:immune system 1155: 1150: 1148: 1147: 1135: 1132: 1124: 1121:November 2020 1113: 1110: 1106: 1103: 1099: 1096: 1092: 1089: 1085: 1082: –  1081: 1077: 1076:Find sources: 1070: 1066: 1060: 1059: 1054:This section 1052: 1048: 1043: 1042: 1034: 1025: 1023: 1019: 1017: 1013: 1009: 1005: 1001: 997: 993: 989: 988:beta-blockers 985: 981: 976: 974: 969: 959: 946: 942: 938: 934: 930: 926: 922: 918: 915: 911: 907: 903: 902:ciclosporines 899: 895: 892: 887: 884: 881: 878: 877: 875: 874:HIV infection 871: 867: 863: 860: 857: 853: 849: 845: 841: 840:Mediterranean 836: 833: 832: 831: 829: 825: 824:Moritz Kaposi 813: 810: 808: 805: 803: 800: 798: 795: 793: 790: 788: 785: 783: 782:Leishmaniasis 780: 778: 775: 773: 770: 768: 765: 762: 759: 758: 757: 756: 747: 745: 741: 736: 734: 730: 713: 708: 701: 696: 689: 684: 680: 679:H&E stain 676: 670: 665: 664: 663: 661: 657: 653: 649: 644: 642: 638: 634: 630: 629:spindle cells 626: 621: 619: 616: 612: 608: 604: 600: 592: 588: 579: 576: 567: 565: 564:circular RNAs 561: 557: 553: 549: 540: 538: 534: 530: 526: 522: 518: 508: 506: 502: 501:malabsorption 498: 487: 485: 481: 473: 469: 464: 455: 453: 449: 445: 441: 437: 433: 429: 425: 416: 408: 399: 396: 394: 390: 386: 382: 377: 375: 371: 361: 359: 355: 354:Moritz Kaposi 350: 348: 344: 340: 336: 331: 329: 325: 324:tissue biopsy 321: 317: 311: 309: 305: 301: 296: 292: 288: 284: 280: 276: 272: 264:20,000 (2018) 263: 259: 255: 251: 248: 244: 240: 236: 232: 229: 225: 221: 217: 214: 212: 208: 205: 201: 200:Tissue biopsy 198: 196: 192: 189: 185: 182: 180: 176: 172: 168: 164: 161: 159: 155: 152: 149: 147: 143: 134: 81: 49: 48: 46: 44:Pronunciation 42: 37: 33: 28: 23: 5815:Rare cancers 5766: 5749: 5738: 5714: 5703: 5692: 5681: 5666: 5651: 5542: 5517: 5492: 5482: 5455: 5423: 5413: 5384: 5376:Parvoviridae 5374: 5299:Genital wart 5289:plantar wart 5263: 5236:Yatapoxvirus 5210:Pseudocowpox 5196:Farmyard pox 5185: 5104: 5093: 5077: 5062: 5035:Roseolovirus 5033: 5027: 5017: 4942: 4860: 4849: 4783:Angiofibroma 4778:angiosarcoma 4733: 4713:Lymphangioma 4631:Microvenular 4573: 4545:Spindle cell 4491:Blood vessel 4362:Ingrown nail 3934:Dermatophyte 3929:Gonococcemia 3914:Folliculitis 3564: 3555:Neurofibroma 3523:subcutaneous 3315: 3311: 3301: 3289:. Retrieved 3285: 3273: 3246: 3242: 3232: 3207: 3203: 3196: 3169: 3165: 3155: 3120: 3116: 3106: 3071: 3067: 3057: 3040: 3036: 3030: 2997: 2993: 2987: 2954: 2950: 2940: 2931: 2925: 2916: 2907: 2890: 2886: 2880: 2853: 2849: 2839: 2815:(4): 583–5. 2812: 2808: 2798: 2763: 2759: 2749: 2714: 2710: 2700: 2665: 2661: 2623: 2619: 2613: 2578: 2574: 2564: 2537: 2533: 2523: 2503: 2467: 2461: 2444: 2440: 2434: 2417: 2413: 2406: 2387: 2381: 2354: 2350: 2340: 2295: 2291: 2281: 2256: 2252: 2246: 2227:Retroviruses 2226: 2219: 2192: 2188: 2178: 2161: 2157: 2150: 2123: 2119: 2109: 2074: 2070: 2060: 2025: 2021: 2011: 1981:(1): 39–43. 1978: 1974: 1968: 1954:(6): 715–8. 1951: 1947: 1937: 1926:. Retrieved 1922:the original 1901: 1897: 1887: 1867: 1860: 1835: 1831: 1821: 1776: 1772: 1742: 1736: 1711: 1707: 1701: 1660: 1656: 1646: 1621: 1617: 1607: 1595:. Retrieved 1590: 1556: 1549: 1517:(3): 94–98. 1514: 1510: 1460: 1456: 1415:. Retrieved 1374: 1370: 1304: 1300: 1290: 1281: 1246: 1242: 1231: 1227: 1190: 1186: 1176: 1151: 1146:Philadelphia 1144: 1142: 1127: 1118: 1108: 1101: 1094: 1087: 1075: 1063:Please help 1058:verification 1055: 1031: 1028:Epidemiology 1022:Alitretinoin 1020: 1008:daunorubicin 984:chemotherapy 977: 965: 956: 916: 893: 885: 879: 861: 852:Israeli Jews 834: 821: 767:Histiocytoma 754: 753: 737: 726: 652:lymph vessel 645: 637:Inflammation 628: 622: 607:histogenesis 596: 577: 573: 570:Transmission 546: 537:bronchoscopy 514: 493: 477: 444:inflammation 421: 397: 378: 367: 351: 335:chemotherapy 332: 312: 274: 270: 269: 239:chemotherapy 179:Risk factors 5740:MedlinePlus 5519:Togaviridae 4683:Angiolipoma 4653:Seriginosum 4626:Glomeruloid 4569:Venous lake 4524:Epithelioid 4417:Herpesvirus 4397:Leukoplakia 4222:Scleroderma 4109:Specialized 4037:Generalized 4012:involvement 3924:Candidiasis 3616:involvement 3590:Myxoid cyst 3438:Acrochordon 2540:(1): 92–4. 2156:patients". 1597:18 December 1012:thalidomide 1004:doxorubicin 980:cryosurgery 618:endothelium 533:chest x-ray 480:hard palate 472:candidiasis 448:lymphoedema 424:lower limbs 287:lymph nodes 5789:Categories 5768:Patient UK 5716:DiseasesDB 5563:Herpangina 5176:Buffalopox 5095:Poxviridae 4974:Chickenpox 4678:of Mibelli 4611:Hemangioma 4529:Kaposiform 4357:Paronychia 4198:Vasculitis 4122:Multiforme 4120:Erythema ( 4075:Cellulitis 4026:Blanchable 3775:Blistering 3765:Ichthyosis 3623:Eczematous 3535:Hemangioma 1928:2007-06-11 1168:References 1091:newspapers 1016:paclitaxel 996:interferon 990:, such as 953:Prevention 948:infection. 910:transplant 862:Endemic KS 675:Micrograph 660:podoplanin 591:Micrograph 552:iatrogenic 5751:eMedicine 5592:Ungrouped 5447:RNA virus 5137:Monkeypox 4917:Cold sore 4841:DNA virus 4705:Lymphatic 4621:Cavernous 4616:Capillary 4534:Infantile 4514:Composite 4352:Psoriasis 4260:disorders 4215:Indurated 4116:Urticaria 4068:Localized 4010:epidermal 3793:Varicella 3703:Psoriasis 3614:epidermal 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Index


/kæˈpsiz/
/ˈkɑːpəsiz,ˈkæpə-/
Specialty
Oncology
Symptoms
Purple
Risk factors
Human herpesvirus 8
poor immune function
Diagnostic method
Tissue biopsy
medical imaging
Differential diagnosis
Blue rubber bleb nevus syndrome
pyogenic granuloma
melanocytic nevi
melanoma
chemotherapy
radiation therapy
biologic therapy
cancer
skin
lymph nodes
organs
purple
immune suppression
HIV/AIDS
Human herpesvirus 8
organ transplantation

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