2073:(IVIG) is the standard treatment for Kawasaki disease and is administered in high doses with marked improvement usually noted within 24 hours. If the fever does not respond, an additional dose may be considered. In rare cases, a third dose may be given. IVIG is most useful within the first seven days of fever onset, to prevent coronary artery aneurysm. IVIG given within the first 10 days of the disease reduces the risk of damage to the coronary arteries in children, without serious adverse effects. A 2023 systematic review and meta-analysis revealed that no prediction models of IVIG resistance in patients with Kawasaki disease could accurately distinguish the resistance. The largest clinical study to date on treatment of resistant Kawasaki disease has shown that
4565:
959:
4601:
827:
2229:
disease. Kawasaki disease is now recognized worldwide. Why cases began to emerge across all continents around the 1960s and 1970s is unclear. Possible explanations could include confusion with other diseases such as scarlet fever, and easier recognition stemming from modern healthcare factors such as the widespread use of antibiotics. In particular, old pathological descriptions from
Western countries of infantile polyarteritis nodosa coincide with reports of fatal cases of Kawasaki disease.
2225:
and reported 23 cases, of which 11 (48%) patients had abnormalities detected by an electrocardiogram. In 1974, the first description of this disorder was published in the
English-language literature. In 1976, Melish et al. described the same illness in 16 children in Hawaii. Melish and Kawasaki had independently developed the same diagnostic criteria for the disorder, which are still used today to make the diagnosis of classic Kawasaki disease.
53:
8607:
Sato T, Fujii Y, Fujiwara T, Hanaoka H, Hata A, KAICA trial
Investigators (March 2019). "Efficacy of primary treatment with immunoglobulin plus ciclosporin for prevention of coronary artery abnormalities in patients with Kawasaki disease predicted to be at increased risk of non-response to intravenous immunoglobulin (KAICA): a randomised controlled, open-label, blinded-endpoints, phase 3 trial".
1562:
1984:, or autoimmunity. Systemic vasculitides may be classified according to the type of cells involved in the proliferation, as well as the specific type of tissue damage occurring within the vein or arterial walls. Under this classification scheme for systemic vasculitis, Kawasaki disease is considered to be a necrotizing vasculitis (also called necrotizing angiitis), which may be identified
355:
2085:
at high doses until the fever subsides, and then is continued at a low dose when the patient returns home, usually for two months to prevent blood clots from forming. Except for
Kawasaki disease and a few other indications, aspirin is otherwise normally not recommended for children due to its association with
1599:. Establishing the diagnosis is difficult, especially early in the course of the illness, and frequently children are not diagnosed until they have seen several health-care providers. Many other serious illnesses can cause similar symptoms, and must be considered in the differential diagnosis, including
2205:
However, its incidence in the United States is increasing. Kawasaki disease is predominantly a disease of young children, with 80% of patients younger than five years of age. About 2,000–4,000 cases are identified in the U.S. each year (9 to 19 per 100,000 children younger than five years of age). In
2145:
Laboratory evidence of increased inflammation combined with demographic features (male sex, age less than six months or greater than eight years) and incomplete response to IVIG therapy create a profile of a high-risk patient with
Kawasaki disease. The likelihood that an aneurysm will resolve appears
2084:
therapy, particularly aspirin, remains an important part of the treatment (though questioned by some) but salicylates alone are not as effective as IVIG. There is limited evidence to indicate whether children should continue to receive salicylate as part of their treatment. Aspirin therapy is started
1968:
research suggests that
Kawasaki disease is associated with a response to a conventional antigen (rather than a superantigen) that involves both activation of the innate immune system and also features of an adaptive immune response. Identification of the exact nature of the immune process involved in
1023:
MI caused by thrombotic occlusion in an aneurysmal, stenotic, or both aneurysmal and stenotic coronary artery is the main cause of death from
Kawasaki disease. The highest risk of MI occurs in the first year after the onset of the disease. MI in children presents with different symptoms from those in
971:
as the most common cause of acquired heart disease in children. Coronary artery aneurysms occur as a sequela of the vasculitis in 20–25% of untreated children. It is first detected at a mean of 10 days of illness and the peak frequency of coronary artery dilation or aneurysms occurs within four weeks
7786:
Morris, Sapna Bamrah; Schwartz, Noah G.; Patel, Pragna; Abbo, Lilian; Beauchamps, Laura; Balan, Shuba; Lee, Ellen H.; Paneth-Pollak, Rachel; Geevarughese, Anita; Lash, Maura K.; Dorsinville, Marie S.; Ballen, Vennus; Eiras, Daniel P.; Newton-Cheh, Christopher; Smith, Emer; Robinson, Sara; Stogsdill,
2201:
Currently, Kawasaki disease is the most commonly diagnosed pediatric vasculitis in the world. By far, the highest incidence of
Kawasaki disease occurs in Japan, with the most recent study placing the attack rate at 218.6 per 100,000 children less than five years of age (about one in 450 children).
2118:
have also been used, especially when other treatments fail or symptoms recur, but in a randomized controlled trial, the addition of corticosteroid to immune globulin and aspirin did not improve outcome. Additionally, corticosteroid use in the setting of
Kawasaki disease is associated with increased
1392:
Genetic susceptibility is suggested by increased incidence among children of
Japanese descent around the world, and also among close and extended family members of affected people. Genetic factors are also thought to influence development of coronary artery aneurysms and response to treatment. The
8606:
Hamada H, Suzuki H, Onouchi Y, Ebata R, Terai M, Fuse S, Okajima Y, Kurotobi S, Hirai K, Soga T, Ishiguchi Y, Okuma Y, Takada N, Yanai M, Sato J, Nakayashiro M, Ayusawa M, Yamamoto E, Nomura Y, Hashimura Y, Ouchi K, Masuda H, Takatsuki S, Hirono K, Ariga T, Higaki T, Otsuki A, Terauchi M, Aoyagi R,
2224:
The disease was first reported by Tomisaku Kawasaki in a four-year-old child with a rash and fever at the Red Cross Hospital in Tokyo in January 1961, and he later published a report on 50 similar cases. Later, Kawasaki and colleagues were persuaded of definite cardiac involvement when they studied
2209:
In the United Kingdom, prior to 2000, it was diagnosed in fewer than one in every 25,000 people per year. Incidence of the disease doubled from 1991 to 2000, however, with four cases per 100,000 children in 1991 compared with a rise of eight cases per 100,000 in 2000. By 2017, this figure had risen
2150:
rather than saccular aneurysm morphology, and an aneurysm location in a distal coronary segment. The highest rate of progression to stenosis occurs among those who develop large aneurysms. The worst prognosis occurs in children with giant aneurysms. This severe outcome may require further treatment
2027:
in diameter. Kawasaki disease is also considered to be a primary childhood vasculitis, a disorder associated with vasculitis that mainly affects children under the age of 18. A recent, consensus-based evaluation of vasculitides occurring primarily in children resulted in a classification scheme for
1935:
Several reported cases suggest that this Kawasaki-like multisystem inflammatory syndrome is not limited to children; there is the possibility of an analogous disease in adults, which has been termed MIS-A. Some suspected patients have presented with positive test results for SARS-CoV-2 and reports
1378:
wind patterns, which suggests wind-borne transport of something capable of triggering an immunologic cascade when inhaled by genetically susceptible children. Winds blowing from central Asia correlate with numbers of new cases of Kawasaki disease in Japan, Hawaii, and San Diego. These associations
2141:
the patient will recover eventually), but the risk of coronary artery involvement is much greater, even many years later. Many cases of myocardial infarction in young adults have now been attributed to Kawasaki disease that went undiagnosed during childhood. Overall, about 2% of patients die from
1649:
Many children, especially infants, eventually diagnosed with Kawasaki disease, do not exhibit all of the above criteria. In fact, many experts now recommend treating for Kawasaki disease even if only three days of fever have passed and at least three diagnostic criteria are present, especially if
2228:
A question was raised whether the disease only started during the period between 1960 and 1970, but later a preserved heart of a seven-year-old boy who died in 1870 was examined and showed three aneurysms of the coronary arteries with clots, as well as pathologic changes consistent with Kawasaki
2127:
have been investigated as possible treatments, with variable outcomes. However, a Cochrane review published in 2017 (updated in 2022) found that, in children, the use of corticosteroids in the acute phase of KD was associated with improved coronary artery abnormalities, shorter hospital stays, a
2111:
after treatment initiation, further research is needed. Due to the potential involvement of the upregulated calcium-nuclear factor of activated T cells pathway in the development of the disease, a 2019 study found that the combination of ciclosporin and IVIG infusion can suppress coronary artery
334:
are involved, ongoing treatment or surgery may occasionally be required. Without treatment, coronary artery aneurysms occur in up to 25% and about 1% die. With treatment, the risk of death is reduced to 0.17%. People who have had coronary artery aneurysms after Kawasaki disease require lifelong
746:
erythematous rash, which is quite nonspecific. The rash varies over time and is characteristically located on the trunk; it may further spread to involve the face, extremities, and perineum. Many other forms of cutaneous lesions have been reported; they may include scarlatiniform, papular,
718:, which is often striking with sharp demarcation and often accompanied by painful, brawny edema of the dorsa of the hands or feet, so affected children frequently refuse to hold objects in their hands or to bear weight on their feet. Later, during the convalescent or the subacute phase,
381:
The first day of fever is considered the first day of the illness, and its duration is typically one to two weeks; in the absence of treatment, it may extend for three to four weeks. Prolonged fever is associated with a higher incidence of cardiac involvement. It responds partially to
730:
within two to three weeks after the onset of fever and may extend to include the palms and soles. Around 11% of children affected by the disease may continue skin-peeling for many years. One to two months after the onset of fever, deep transverse grooves across the nails may develop
972:
of onset. Aneurysms are classified into small (internal diameter of vessel wall <5 mm), medium (diameter ranging from 5–8 mm), and giant (diameter > 8 mm). Saccular and fusiform aneurysms usually develop between 18 and 25 days after the onset of illness.
2146:
to be determined in large measure by its initial size, in which the smaller aneurysms have a greater likelihood of regression. Other factors are positively associated with the regression of aneurysms, including being younger than a year old at the onset of Kawasaki disease,
818:
may be present and are manifested by the presence of inflammatory cells in the affected tissues. If left untreated, some symptoms will eventually relent, but coronary artery aneurysms will not improve, resulting in a significant risk of death or disability due to
1011:
concentrations, male sex, and age less than one year. Coronary artery lesions resulting from Kawasaki disease change dynamically with time. Resolution one to two years after the onset of the disease has been observed in half of vessels with coronary aneurysms.
1779:
Based on clinical findings, a diagnostic distinction may be made between the "classic" or "typical" presentation of Kawasaki disease and "incomplete" or "atypical" presentation of a "suspected" form of the disease. Regarding incomplete/atypical presentation,
405:
has been reported to be the most common symptom after fever. It typically involves the bulbar conjunctivae, is not accompanied by suppuration, and is not painful. This usually begins shortly after the onset of fever during the acute stage of the disease.
2179:, and rarely, other serious reactions. Overall, life-threatening complications resulting from therapy for Kawasaki disease are exceedingly rare, especially compared with the risk of nontreatment. Evidence indicates Kawasaki disease produces altered
1788:
of prolonged unexplained fever in childhood associated with any of the principal clinical features of the disease, and the diagnosis can be considered confirmed when coronary artery aneurysms are identified in such patients by echocardiography."
272:. Within three weeks of the onset, the skin from the hands and feet may peel, after which recovery typically occurs. The disease is the leading cause of acquired heart disease in children in developed countries, which include the formation of
2128:
decreased duration of clinical symptoms, and reduced inflammatory marker levels. Patient populations based in Asia, people with higher risk scores, and those receiving longer steroid treatment may have greater benefit from steroid use.
979:
regimens within the first 10 days of illness, 5% of children with Kawasaki disease develop at the least transient coronary artery dilation and 1% develop giant aneurysms. Death can occur either due to myocardial infarction secondary to
1383:
in winds and sea surface temperatures over the tropical eastern Pacific Ocean. Efforts have been made to identify a possible pathogen in air-filters flown at altitude above Japan. One source has been suggested in northeastern China.
2028:
these disorders, to distinguish them and suggest a more concrete set of diagnostic criteria for each. Within this classification of childhood vasculitides, Kawasaki disease is, again, a predominantly medium-sized vessel vasculitis.
5108:
Fuyama Y, Hamada R, Uehara R, Yano I, Fujiwara M, Matoba M, et al. (June 1996). "Long-term follow up of abdominal aortic aneurysm complicating Kawasaki disease: comparison of the effectiveness of different imaging methods".
4652:"Guidelines for long-term management of patients with Kawasaki disease. Report from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association"
1137:. This change in the vascular tone is secondary to endothelial dysfunction. In addition, children with Kawasaki disease, with or without coronary artery complications, may have a more adverse cardiovascular risk profile, such as
338:
Kawasaki disease is rare. It affects between 8 and 67 per 100,000 people under the age of five except in Japan, where it affects 124 per 100,000. Boys are more commonly affected than girls. The disorder is named after Japanese
2022:
Kawasaki disease may be further classified as a medium-sized vessel vasculitis, affecting medium- and small-sized blood vessels, such as the smaller cutaneous vasculature (veins and arteries in the skin) that range from 50 to
8958:
Akagi T, Ogawa S, Ino T, Iwasa M, Echigo S, Kishida K, et al. (August 2000). "Catheter interventional treatment in Kawasaki disease: A report from the Japanese Pediatric Interventional Cardiology Investigation group".
1066:-induced myocardial dysfunction, regardless of coronary involvement. These lesions mostly disappear with the resolution of acute illness, but a very small group of the lesions persist and progress. There is also late-onset
966:
Heart complications are the most important aspect of Kawasaki disease, which is the leading cause of heart disease acquired in childhood in the United States and Japan. In developed nations, it appears to have replaced
1364:(i.e. one commonly associated with excessive immune system activation). Current consensus favors an excessive immunologic response to a conventional antigen which usually provides future protection. Research points to
2077:
is more effective and safer than a second dose of IVIG in treating children with IVIG-resistant Kawasaki Disease, offering faster fever resolution and reduced hospitalization times without significant adverse events.
1764:
was historically used to detect coronary artery aneurysms, and remains the gold standard for their detection, but is rarely used today unless coronary artery aneurysms have already been detected by echocardiography.
9639:
9624:
2206:
the continental United States, Kawasaki disease is more common during the winter and early spring, boys with the disease outnumber girls by ≈1.5–1.7:1, and 76% of affected children are less than 5 years of age.
2174:
of symptoms may occur soon after initial treatment with IVIG. This usually requires rehospitalization and retreatment. Treatment with IVIG can cause allergic and nonallergic acute reactions, aseptic meningitis,
458:
is seen in 50% to 75% of children, whereas the other features are estimated to occur in 90%, but sometimes it can be the dominant presenting symptom. According to the diagnostic criteria, at least one impaired
463:≥ 15 mm in diameter should be involved. Affected lymph nodes are painless or minimally painful, nonfluctuant, and nonsuppurative; erythema of the neighboring skin may occur. Children with fever and neck
2136:
With early treatment, rapid recovery from the acute symptoms can be expected, and the risk of coronary artery aneurysms is greatly reduced. Untreated, the acute symptoms of Kawasaki disease are self-limited
1405:(SNPs), mostly found in genes with immune regulatory functions. The associated genes and their levels of expression appear to vary among different ethnic groups, both with Asian and non-Asian backgrounds.
7787:
Patricia; Lim, Sarah; Fox, Sharon E.; Richardson, Gillian; Hand, Julie; Oliver, Nora T.; Kofman, Aaron; Bryant, Bobbi; Ende, Zachary; Datta, Deblina; Belay, Ermias; Godfred-Cato, Shana (9 October 2020).
8783:
Beiser AS, Takahashi M, Baker AL, Sundel RP, Newburger JW (May 1998). "A predictive instrument for coronary artery aneurysms in Kawasaki disease. US Multicenter Kawasaki Disease Study Group".
4931:
Suzuki A, Kamiya T, Tsuchiya K, Sato I, Arakaki Y, Kohata T, Ono Y (February 1988). "Tricuspid and mitral regurgitation detected by color flow Doppler in the acute phase of Kawasaki disease".
2055:
Children with Kawasaki disease should be hospitalized and cared for by a physician who has experience with this disease. In an academic medical center, care is often shared between pediatric
1650:
other tests reveal abnormalities consistent with Kawasaki disease. In addition, the diagnosis can be made purely by the detection of coronary artery aneurysms in the proper clinical setting.
370:. This is the most prominent symptom of Kawasaki disease, and is a characteristic sign that the disease is in its acute phase; the fever normally presents as a high (above 39–40 °C) and
4160:
Fujiwara H, Fujiwara T, Kao TC, Ohshio G, Hamashima Y (June 1986). "Pathology of Kawasaki disease in the healed stage. Relationships between typical and atypical cases of Kawasaki disease".
5042:
Fukunaga S, Egashira A, Arinaga K, Akasu I, Kai E, Higashi T, et al. (March 1996). "Aortic valve replacement for aortic regurgitation due to Kawasaki disease. Report of two cases".
4615:
Terai M, Shulman ST (December 1997). "Prevalence of coronary artery abnormalities in Kawasaki disease is highly dependent on gamma globulin dose but independent of salicylate dose".
2067:
specialists (although no specific infectious agent has yet been identified). To prevent damage to coronary arteries, treatment should be started immediately following the diagnosis.
8818:
Fujiwara T, Fujiwara H, Hamashima Y (1987). "Size of coronary aneurysm as a determinant factor of the prognosis in Kawasaki disease: clinicopathologic study of coronary aneurysms".
425:
Kawasaki disease also presents with a set of mouth symptoms, the most characteristic of which are a red tongue, swollen lips with vertical cracking, and bleeding. The mucosa of the
5152:
Miyake T, Yokoyama T, Shinohara T, Seto S, Oiki M (August 1995). "Transient dilatation of the abdominal aorta in an infant with Kawasaki disease associated with thrombocytopenia".
7059:
Rodó, X; Curcoll, R; Robinson, M; Ballester, J; Burns, JC; Cayan, DR; Lipkin, WI; Williams, BL; Couto-Rodriguez, M; Nakamura, Y; Uehara, R; Tanimoto, H; Morguí, JA (3 June 2014).
4521:
Suzuki A, Kamiya T, Kuwahara N, Ono Y, Kohata T, Takahashi O, et al. (1986). "Coronary arterial lesions of Kawasaki disease: cardiac catheterization findings of 1100 cases".
2232:
In the United States and other developed nations, Kawasaki disease appears to have replaced acute rheumatic fever as the most common cause of acquired heart disease in children.
2194:
Kawasaki disease affects boys more than girls, with people of Asian ethnicity, particularly Japanese people. The higher incidence in Asian populations is thought to be linked to
8995:
4312:"Kawasaki disease: guidelines of the Italian Society of Pediatrics, part I – definition, epidemiology, etiopathogenesis, clinical expression and management of the acute phase"
1444:
have all been linked to susceptibility, prognosis, and risk of developing coronary artery aneurysms. Various other possible susceptibility genes have been proposed, including
7533:
Kuo HC, Liang CD, Wang CL, Yu HR, Hwang KP, Yang KD (October 2010). "Serum albumin level predicts initial intravenous immunoglobulin treatment failure in Kawasaki disease".
4443:
Burns JC, Wiggins JW, Toews WH, Newburger JW, Leung DY, Wilson H, Glodé MP (November 1986). "Clinical spectrum of Kawasaki disease in infants younger than 6 months of age".
2638:
1816:
The broadness of the differential diagnosis is a challenge to timely diagnosis of Kawasaki disease. Infectious and noninfectious conditions requiring consideration include:
935:
Adult onset of Kawasaki disease is rare. The presentation differs between adults and children: in particular, it seems that adults more often have cervical lymphadenopathy,
8685:
Newburger JW, Sleeper LA, McCrindle BW, Minich LL, Gersony W, Vetter VL, Atz AM, Li JS, Takahashi M, Baker AL, Colan SD, Mitchell PD, Klein GL, Sundel RP (February 2007).
5752:
Ohno S, Miyajima T, Higuchi M, Yoshida A, Matsuda H, Saheki Y, et al. (June 1982). "Ocular manifestations of Kawasaki's disease (mucocutaneous lymph node syndrome)".
6672:"Monthly observation of the number of patients with Kawasaki disease and its incidence rates in Japan: chronological and geographical observation from nationwide surveys"
8915:
Ishii M, Ueno T, Akagi T, Baba K, Harada K, Hamaoka K, et al. (October 2001). "Guidelines for catheter intervention in coronary artery lesion in Kawasaki disease".
6145:
Muneuchi J, Kusuhara K, Kanaya Y, Ohno T, Furuno K, Kira R, et al. (January 2006). "Magnetic resonance studies of brain lesions in patients with Kawasaki disease".
9407:
Kawasaki T, Kosaki F, Okawa S, Shigematsu I, Yanagawa H (September 1974). "A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan".
5381:
Ooyanagi R, Fuse S, Tomita H, Takamuro M, Horita N, Mori M, Tsutsumi H (August 2004). "Pulse wave velocity and ankle brachial index in patients with Kawasaki disease".
4283:
5717:
Zulian F, Falcini F, Zancan L, Martini G, Secchieri S, Luzzatto C, Zacchello F (June 2003). "Acute surgical abdomen as presenting manifestation of Kawasaki disease".
3224:
Mori M, Imagawa T, Yasui K, Kanaya A, Yokota S (August 2000). "Predictors of coronary artery lesions after intravenous gamma-globulin treatment in Kawasaki disease".
3469:
Bachmeyer C, Turc Y, Curan D, Duval-Arnould M (January 2000). "Anterior uveitis as the initial sign of adult Kawasaki syndrome (mucocutaneous lymph node syndrome)".
908:
resolve at about one to two weeks after the onset of fever, but irritability, anorexia, and conjunctival injection persist. Desquamation of the fingers and toes and
7683:
1044:
was most common in older children. Most of these children had the attack occurring during sleep or at rest, and around one-third of attacks were asymptomatic.
2508:
McCrindle BW, Rowley AH, Newburger JW, Burns JC, Bolger AF, Gewitz M, Baker AL, Jackson MA, Takahashi M, Shah PB, Kobayashi T, Wu MH, Saji TT, Pahl E (2017).
2350:
9329:"P134 Collaborating with the National Congenital Anomaly and Rare Disease Registration Service to estimate national incidence of Kawasaki disease in England"
3178:
Rodriguez-Lozano AL, Rivas-Larrauri FE, Hernandez-Bautista VM, Yamazaki-Nakashimada MA (September 2012). "Fever is not always present in Kawasaki disease".
1016:
of the coronary artery, which occurs as a result of the healing process of the vessel wall, often leads to significant obstruction of the blood vessel and
8225:
7511:
3361:
6493:
2510:"Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association"
8650:
Sundel RP, Baker AL, Fulton DR, Newburger JW (June 2003). "Corticosteroids in the initial treatment of Kawasaki disease: report of a randomized trial".
7789:"Case Series of Multisystem Inflammatory Syndrome in Adults Associated with SARS-CoV-2 Infection — United Kingdom and United States, March–August 2020"
2103:
About 15-20% of children following the initial IVIG infusion show persistent or recurrent fever and are classified as IVIG-resistant. While the use of
1542:†A diagnosis of Kawasaki disease can be made if fever and only three changes are present if coronary artery disease is documented by two-dimensional
950:, have atypical presentations without the classic set of symptoms. Such presentations are associated with a higher risk of cardiac artery aneurysms.
378:. Recently, it is reported to be present in patients with atypical or incomplete Kawasaki disease; nevertheless, it is not present in 100% of cases.
9295:
7666:
2216:
Coronary artery aneurysms due to Kawasaki disease are believed to account for 5% of acute coronary syndrome cases in adults under 40 years of age.
5518:
3360:
Martínez Ruiz M, del Castillo Martín F, Borque Andrés C, García Miguel MJ, de José Gómez MI, Martínez Cortés F, Baquero Artigao F (October 2003).
5641:
Beiler HA, Schmidt KG, von Herbay A, Löffler W, Daum R (April 2001). "Ischemic small bowel strictures in a case of incomplete Kawasaki disease".
3534:
Kubota M, Usami I, Yamakawa M, Tomita Y, Haruta T (June 2008). "Kawasaki disease with lymphadenopathy and fever as sole initial manifestations".
252:, where medium-sized blood vessels become inflamed throughout the body. The fever typically lasts for more than five days and is not affected by
8144:
Guillevin L, Pagnoux C, Guilpain P (May 2007). "Classification des vascularites systémiques" [Classification of systemic vasculatides].
4244:
Tse SM, Silverman ED, McCrindle BW, Yeung RS (April 2002). "Early treatment with intravenous immunoglobulin in patients with Kawasaki disease".
10026:
303:
and blood tests may support the diagnosis. Diagnosis must take into account many other conditions that may present similar features, including
7616:
5857:
Farvardin M, Kashef S, Aleyasin S, Nabavizadeh SH, Sajjadi M, Safari M (2007). "Sudden unilateral blindness in a girl with Kawasaki disease".
10016:
9889:
9783:
3143:
Rowley AH, Gonzalez-Crussi F, Gidding SS, Duffy CE, Shulman ST (March 1987). "Incomplete Kawasaki disease with coronary artery involvement".
2119:
risk of coronary artery aneurysm, so its use is generally contraindicated in this setting. In cases of Kawasaki disease refractory to IVIG,
2044:
2016:
1925:
312:
9597:
5245:
Yang G, Thompson D, Warren A (February 2009). "Late-appearing brachiocephalic aneurysm: an atypical vascular sequella of Kawasaki disease".
8845:
Nakano H, Ueda K, Saito A, Nojima K (November 1985). "Repeated quantitative angiograms in coronary arterial aneurysm in Kawasaki disease".
6028:
Bailie NM, Hensey OJ, Ryan S, Allcut D, King MD (2001). "Bilateral subdural collections--an unusual feature of possible Kawasaki disease".
1909:
178:
6467:
7891:"SARS-CoV-2-Related Inflammatory Multisystem Syndrome in Children: Different or Shared Etiology and Pathophysiology as Kawasaki Disease?"
4966:
Akagi T, Kato H, Inoue O, Sato N, Imamura K (August 1990). "Valvular heart disease in Kawasaki syndrome: incidence and natural history".
4566:"The prevention of coronary artery aneurysm in Kawasaki disease: a meta-analysis on the efficacy of aspirin and immunoglobulin treatment"
2465:
1360:. Despite intensive search, no single pathogen has been identified. There has been debate as to whether the infectious agent might be a
519:
1929:
1216:
The neurological complications per central nervous system lesions are increasingly reported. The neurological complications found are
9561:
Taubert KA, Rowley AH, Shulman ST (1995). "A 10 year (1984–1993) United States hospital survey of Kawasaki disease". In Kato H (ed.).
10031:
9034:
8466:
9733:
8880:
Tatara K, Kusakawa S (November 1987). "Long-term prognosis of giant coronary aneurysm in Kawasaki disease: an angiographic study".
8555:
Yamaji N, da Silva Lopes K, Shoda T, Ishitsuka K, Kobayashi T, Ota E, Mori R, et al. (Cochrane Vascular Group) (August 2019).
7445:
2298:
1924:
is examining possible links with COVID-19. This emerging condition was named "paediatric multisystem inflammatory syndrome" by the
1572:
8348:
8114:
7617:
Sharma C, Ganigara M, Galeotti C, Burns J, Berganza FM, Hayes DA, Singh-Grewal D, Bharath S, Sajjan S, Bayry J (29 October 2021).
5429:"Novel and traditional cardiovascular risk factors in children after Kawasaki disease: implications for premature atherosclerosis"
299:, that is, it does not spread between people. Diagnosis is usually based on a person's signs and symptoms. Other tests such as an
9360:
991:
Many risk factors predicting coronary artery aneurysms have been identified, including persistent fever after IVIG therapy, low
3680:
Stamos JK, Corydon K, Donaldson J, Shulman ST (March 1994). "Lymphadenitis as the dominant manifestation of Kawasaki disease".
2848:
5003:"Mucocutaneous lymph node syndrome (Kawasaki disease): delayed aortic and mitral insufficiency secondary to active valvulitis"
3261:"A single intravenous infusion of gamma globulin as compared with four infusions in the treatment of acute Kawasaki syndrome"
2329:
2152:
4279:
1944:
Debate has occurred about whether Kawasaki disease should be viewed as a characteristic immune response to some infectious
1808:
has been proposed to categorize 'definite' (i.e. complete/incomplete), 'probable' and 'possible' cases of Kawasaki disease.
9313:
3100:
Fukushige J, Takahashi N, Ueda Y, Ueda K (October 1994). "Incidence and clinical features of incomplete Kawasaki disease".
2602:
2032:
1889:
2202:
At this present attack rate, more than one in 150 children in Japan will develop Kawasaki disease during their lifetimes.
1081:, with the timing ranging from several months to years after the onset of Kawasaki disease. Some of these lesions require
9654:
4896:
Kato H, Ichinose E, Kawasaki T (June 1986). "Myocardial infarction in Kawasaki disease: clinical analyses in 195 cases".
3957:
1792:
A further distinction between incomplete and atypical subtypes may also be made in the presence of non-typical symptoms.
7493:
5892:
Tomita S, Chung K, Mas M, Gidding S, Shulman ST (January 1992). "Peripheral gangrene associated with Kawasaki disease".
5557:
Yaniv L, Jaffe M, Shaoul R (September 2005). "The surgical manifestations of the intestinal tract in Kawasaki disease".
1936:
suggest intravenous immunoglobulin, anticoagulation, tocilizumab, plasmapheresis and steroids are potential treatments.
1380:
9996:
9935:
6110:
Fujiwara S, Yamano T, Hattori M, Fujiseki Y, Shimada M (1992). "Asymptomatic cerebral infarction in Kawasaki disease".
531:
4478:
Boven K, De Graeff-Meeder ER, Spliet W, Kuis W (August 1992). "Atypical Kawasaki disease: an often missed diagnosis".
2743:"Emerging Insights Into the Pathophysiology of Multisystem Inflammatory Syndrome Associated With COVID-19 in Children"
9950:
9914:
9776:
9140:
7332:
7192:
5993:
Aoki N (March 1988). "Subdural effusion in the acute stage of Kawasaki disease (Mucocutaneous lymph node syndrome)".
2639:"European consensus-based recommendations for the diagnosis and treatment of Kawasaki disease – the SHARE initiative"
2459:
17:
8415:
Baumer JH, Love SJ, Gupta A, Haines LC, Maconochie I, Dua JS, et al. (Cochrane Vascular Group) (October 2006).
422:
are another eye manifestation (detectable by a slit lamp, but are usually too small to be seen by the unaided eye).
362:
Kawasaki disease often begins with a high and persistent fever that is not very responsive to normal treatment with
9875:
7061:"Tropospheric winds from northeastern China carry the etiologic agent of Kawasaki disease from its source to Japan"
2036:
2008:
1976:, of the arteries and veins occurs throughout the body, usually caused by increased production of the cells of the
9945:
9563:
Kawasaki disease: Proceedings of the 5th International Kawasaki Disease Symposium, Fukuoka, Japan, 22–25 May 1995
8498:"High-Dose Aspirin is Associated with Anemia and Does Not Confer Benefit to Disease Outcomes in Kawasaki Disease"
4764:
Koren G, Lavi S, Rose V, Rowe R (March 1986). "Kawasaki disease: review of risk factors for coronary aneurysms".
1402:
1394:
9919:
8233:
7578:"Kawasaki disease and immunisation: Standardised case definition & guidelines for data collection, analysis"
7507:
4030:
Kwan YW, Leung CW (December 2005). "Pustulo-vesicular skin eruption in a child with probable Kawasaki disease".
2012:
1153:
9570:
7838:
Shaigany, Sheila; Gnirke, Marlis; Guttman, Allison; Chong, Hong; Meehan, Shane; Raabe, Vanessa (10 July 2020).
5334:"Relationship between carotid intima-media thickness and arterial stiffness in children after Kawasaki disease"
3956:
López Neyra A, Alvarez-Coca González J, Pérez Suárez E, Martínez Pérez J, Rubio Villanueva JL (December 2007).
3084:
1679:
928:
8258:
Oates-Whitehead RM, Baumer JH, Haines L, Love S, Maconochie IK, Gupta A, et al. (2003). Baumer JH (ed.).
2089:. Because children with Kawasaki disease will be taking aspirin for up to several months, vaccination against
778:
In the acute stage of Kawasaki disease, systemic inflammatory changes are evident in many organs. Joint pain (
9157:
8229:
1608:
1348:
are unusual in Kawasaki disease, it is thought that the trigger is more likely to be represented by a single
1169:
962:
X-ray showing aneurysmal enlargement of the coronary arteries, which is a complication in a Kawasaki syndrome
535:
308:
174:
6489:
2112:
abnormalities. Further research is needed to determine which patients would respond best to this treatment.
10001:
9769:
9051:
Checchia PA, Pahl E, Shaddy RE, Shulman ST (October 1997). "Cardiac transplantation for Kawasaki disease".
7712:"Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with Coronavirus Disease 2019 (COVID-19)"
1845:
1270:, or even a cerebral infarction with no neurological manifestations. Other neurological complications from
490:
9291:
9234:
3995:
González Pascual E, Villanueva Lamas J, Ros Viladoms J, Pons Odena M, Ruiz García-Diego S (January 1999).
1325:
The specific cause of Kawasaki disease is unknown. A plausible explanation is that it may be caused by an
9940:
9749:
7966:
7465:
1452:
region, but their significance is disputed. Genetic susceptibility to Kawasaki disease appears complex.
685:
10021:
9841:
3399:
Svobodová D, Slaný J, Pískovský T (2008). "" [Kawasaki disease and its ocular manifestations].
2792:"Multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2: a systematic review"
2070:
1893:
1781:
1352:, rather than a range of viral or bacterial agents. Various candidates have been implicated, including
1283:
877:, erythema of the oral mucosa, erythema and swelling of the hands and feet, rash, cervical adenopathy,
391:
9450:
Melish ME, Hicks RM, Larson EJ (June 1976). "Mucocutaneous lymph node syndrome in the United States".
3426:
Burns JC, Joffe L, Sargent RA, Glode MP (1985). "Anterior uveitis associated with Kawasaki syndrome".
988:
of a large coronary artery aneurysm. Death is most common two to 12 weeks after the onset of illness.
9906:
1921:
1206:
3177:
1337:
children. The pathogenesis is complex and incompletely understood. Various explanations exist. (See
9894:
9665:
9208:
8307:
Kuniyoshi Y, Tsujimoto Y, Banno M, Taito S, Ariie T, Takahashi N, Tokutake H, Takada T (May 2023).
6411:
5069:
Ravekes WJ, Colan SD, Gauvreau K, Baker AL, Sundel RP, van der Velde ME, et al. (April 2001).
4650:
Dajani AS, Taubert KA, Takahashi M, Bierman FZ, Freed MD, Ferrieri P, et al. (February 1994).
2156:
2040:
1841:
1583:
Since no specific laboratory test exists for Kawasaki disease, diagnosis must be based on clinical
1047:
912:
are seen during this stage, which generally lasts until about four weeks after the onset of fever.
455:
273:
111:
8309:"Prediction Models for Intravenous Immunoglobulin Resistance in Kawasaki Disease: A Meta-analysis"
3580:
Scardina GA, Fucà G, Carini F, Valenza V, Spicola M, Procaccianti P, et al. (December 2007).
9808:
2164:
1865:
1727:
1496:
1449:
1353:
1122:
106:
9823:
9256:
Holman, R. C. (2003). "Kawasaki Syndrome Hospitalizations in the United States, 1997 and 2000".
6236:
1121:
aneurysm. Other vascular complications can occur such as increased wall thickness and decreased
10006:
9851:
9800:
8349:"Comparing Two Treatments for IVIG-Resistant Kawasaki Disease - Evidence Update for Clinicians"
6463:
5544:
2195:
1961:
1869:
1857:
1785:
1334:
1157:
1106:
874:
799:
707:
659:
643:
626:
611:
583:
550:
468:
292:
165:
9705:
9489:
6416:"Searching for the cause of Kawasaki disease-cytoplasmic inclusion bodies provide new insight"
4808:"Long-term consequences of Kawasaki disease. A 10- to 21-year follow-up study of 594 patients"
3259:
Newburger JW, Takahashi M, Beiser AS, Burns JC, Bastian J, Chung KJ, et al. (June 1991).
2449:
1093:
Other Kawasaki disease complications have been described, such as aneurysm of other arteries:
9975:
9130:
8687:"Randomized trial of pulsed corticosteroid therapy for primary treatment of Kawasaki disease"
7660:
5468:
Senzaki H, Chen CH, Ishido H, Masutani S, Matsunaga T, Taketazu M, et al. (April 2005).
3996:
3581:
2100:
High-dose aspirin is associated with anemia and does not confer benefit to disease outcomes.
1861:
1837:
968:
820:
772:
411:
8179:
Jennette JC, Falk RJ (October 2000). "Do vasculitis categorization systems really matter?".
6909:
Rodó X, Ballester J, Cayan D, Melish ME, Nakamura Y, Uehara R, Burns JC (10 November 2011).
3724:
2210:
to 12 in 100,000 people with 419 diagnosed cases of Kawasaki disease in the United Kingdom.
9970:
9831:
9813:
8509:
7619:"Multisystem inflammatory syndrome in children and Kawasaki disease: a critical comparison"
7072:
7023:
6982:
6967:
6922:
5291:
Dhillon R, Clarkson P, Donald AE, Powe AJ, Nash M, Novelli V, et al. (November 1996).
4364:
Hirose O, Misawa H, Kijima Y, Yamada O, Arakaki Y, Kajino Y, et al. (March 1981). "".
4114:
Dajani AS, Taubert KA, Gerber MA, Shulman ST, Ferrieri P, Freed M, et al. (May 1993).
2352:
Guidance – Paediatric multisystem inflammatory syndrome temporally associated with COVID-19
2004:
1957:
1691:
1665:
1596:
1547:
1134:
1071:
1020:. This can eventually lead to heart muscle tissue death, i.e., myocardial infarction (MI).
917:
835:
823:. If treated quickly, this risk can be mostly avoided and the course of illness cut short.
739:
590:
499:
330:. Usually, with treatment, fever resolves within 24 hours and full recovery occurs. If the
8474:
3955:
3359:
927:
stage begins when all clinical signs of illness have disappeared, and continues until the
8:
10011:
9792:
9716:
9643:
9463:
7357:"EULAR/PReS endorsed consensus criteria for the classification of childhood vasculitides"
1695:
1616:
1422:
1314:
1217:
1210:
1165:
1138:
1110:
1025:
1017:
882:
752:
655:
467:
who do not respond to antibiotics should have Kawasaki disease considered as part of the
419:
8513:
7840:"An adult with Kawasaki-like multisystem inflammatory syndrome associated with COVID-19"
7076:
7027:
6986:
6926:
2290:
1932:. Guidance for diagnosis and reporting of cases has been issued by these organizations.
1464:
has been proposed as an early mechanistic factor during the acute phase of the disease.
1182:
changes associated with the disease have been described since the 1980s, being found as
9543:
9432:
9345:
9328:
9190:
9111:
9026:
8940:
8760:
8727:
8632:
8583:
8556:
8532:
8497:
8443:
8416:
8284:
8259:
8204:
8054:
8014:
7989:
7866:
7839:
7815:
7788:
7763:
7738:
7643:
7618:
7558:
7381:
7356:
7300:
7275:
7251:
7226:
7203:
7184:
7149:
7122:
7095:
7060:
6943:
6910:
6891:
6839:
6812:
6793:
6745:
6720:
6696:
6671:
6603:
6576:
6552:
6525:
6440:
6415:
6346:
6319:
6217:
6170:
5618:
5593:
5535:
5527:
5486:
5469:
5406:
5358:
5333:
5270:
5177:
5165:
5134:
5122:
4806:
Kato H, Sugimura T, Akagi T, Sato N, Hashino K, Maeno Y, et al. (September 1996).
4743:
4731:
4593:
4546:
4503:
4420:
4395:
4338:
4311:
4185:
4173:
4055:
3930:
3905:
3881:
3856:
3791:
3766:
3705:
3559:
3451:
3337:
3312:
3203:
3125:
3113:
2896:
2871:
2818:
2791:
2767:
2742:
2718:
2691:
2669:
2420:
2395:
2064:
1755:
1685:
1345:
1298:
1008:
958:
878:
803:
650:
639:
619:
566:
543:
449:
438:
296:
269:
85:
9648:
8893:
8796:
8620:
7856:
5944:
5222:
5205:
5086:
5019:
5002:
4909:
4777:
4718:
Harada K (December 1991). "Intravenous gamma-globulin treatment in Kawasaki disease".
4628:
4456:
4310:
Marchesi A, Tarissi de Jacobis I, Rigante D, Rimini A, Malorni W, et al. (2018).
4073:
Ulloa-Gutierrez R, Acón-Rojas F, Camacho-Badilla K, Soriano-Fallas A (December 2007).
4072:
3994:
3973:
3743:
3482:
3377:
3156:
2031:
It can also be classed as an autoimmune form of vasculitis. It is not associated with
9676:
9576:
9566:
9535:
9467:
9424:
9273:
9182:
9136:
9115:
9103:
9068:
9018:
9014:
8976:
8932:
8928:
8897:
8862:
8858:
8827:
8800:
8765:
8747:
8708:
8667:
8624:
8588:
8537:
8448:
8397:
8330:
8289:
8196:
8161:
8126:
8095:
8046:
8019:
7948:
7912:
7871:
7820:
7768:
7648:
7599:
7550:
7546:
7485:
7427:
7386:
7328:
7305:
7276:"Predisposing factors, pathogenesis and therapeutic intervention of Kawasaki disease"
7256:
7188:
7154:
7100:
7041:
6948:
6895:
6883:
6863:
6844:
6785:
6781:
6750:
6701:
6652:
6608:
6557:
6445:
6392:
6351:
6300:
6259:
6221:
6209:
6162:
6127:
6123:
6089:
6045:
6010:
6006:
5975:
5948:
5909:
5874:
5839:
5804:
5769:
5765:
5734:
5699:
5658:
5623:
5574:
5510:
5491:
5450:
5398:
5394:
5363:
5314:
5262:
5227:
5169:
5126:
5090:
5051:
5024:
4983:
4979:
4948:
4944:
4913:
4873:
4829:
4781:
4735:
4700:
4673:
4632:
4585:
4538:
4495:
4460:
4425:
4373:
4343:
4261:
4226:
4177:
4137:
4096:
4047:
4012:
3977:
3935:
3886:
3837:
3796:
3747:
3697:
3662:
3596:
3551:
3547:
3513:
3486:
3443:
3439:
3408:
3381:
3342:
3282:
3241:
3195:
3160:
3117:
3080:
3057:
3013:
3008:
2983:
2931:
2901:
2823:
2772:
2723:
2661:
2610:
2563:
2531:
2455:
2425:
2325:
2108:
1710:
1706:
1669:
1623:
1612:
1500:
1445:
1310:
1251:
1232:
1221:
1082:
885:. Myocarditis is common during this time, and a pericardial effusion may be present.
727:
511:
434:
383:
343:
331:
225:
152:
65:
9547:
9436:
9194:
9030:
8944:
8636:
8376:"Treatment of acute Kawasaki disease: aspirin's role in the febrile stage revisited"
8208:
8090:
8073:
8058:
8037:
Rigante D (2006). "Clinical overview of vasculitic syndromes in the pediatric age".
7562:
7355:
Ozen S, Ruperto N, Dillon MJ, Bagga A, Barron K, Davin JC, et al. (July 2006).
6797:
6189:
6174:
5928:
5410:
5274:
5181:
5138:
4747:
4597:
4550:
4189:
4059:
3832:
3815:
3709:
3657:
3640:
3563:
3455:
3129:
2844:
2673:
2319:
1996:, and proliferation of cells associated with inflammation in the inner layer of the
1152:
Gastrointestinal complications in Kawasaki disease are similar to those observed in
873:
febrile phase, which usually lasts for one to two weeks, is characterized by fever,
9727:
9527:
9459:
9416:
9340:
9265:
9172:
9095:
9060:
9010:
8968:
8924:
8889:
8854:
8792:
8755:
8743:
8739:
8698:
8659:
8616:
8578:
8573:
8568:
8527:
8517:
8438:
8433:
8428:
8387:
8320:
8279:
8271:
8188:
8153:
8085:
8009:
8001:
7902:
7861:
7851:
7810:
7800:
7758:
7750:
7638:
7630:
7589:
7542:
7417:
7376:
7368:
7295:
7287:
7246:
7238:
7198:
7180:
7144:
7134:
7090:
7080:
7031:
6990:
6938:
6930:
6875:
6834:
6824:
6777:
6740:
6732:
6691:
6683:
6642:
6598:
6588:
6547:
6537:
6435:
6427:
6382:
6341:
6331:
6290:
6251:
6201:
6158:
6154:
6119:
6079:
6037:
6002:
5940:
5901:
5866:
5831:
5796:
5761:
5726:
5689:
5650:
5613:
5605:
5570:
5566:
5502:
5481:
5440:
5390:
5353:
5345:
5304:
5254:
5217:
5161:
5118:
5082:
5014:
4975:
4940:
4905:
4863:
4819:
4773:
4727:
4663:
4624:
4577:
4530:
4507:
4487:
4452:
4415:
4407:
4333:
4323:
4253:
4216:
4169:
4127:
4086:
4039:
3969:
3925:
3917:
3876:
3868:
3827:
3786:
3778:
3739:
3689:
3652:
3543:
3504:
Smith LB, Newburger JW, Burns JC (February 1989). "Kawasaki syndrome and the eye".
3478:
3435:
3373:
3332:
3324:
3272:
3233:
3207:
3187:
3152:
3109:
3047:
3003:
2995:
2891:
2883:
2813:
2803:
2762:
2754:
2713:
2703:
2653:
2553:
2521:
2415:
2407:
2180:
2120:
1989:
1969:
Kawasaki disease could help guide research aimed at improving clinical management.
1953:
1714:
1543:
1259:
1126:
1114:
1055:
1000:
894:
870:
663:
407:
9738:
7711:
7594:
7577:
5835:
5800:
2657:
9670:
9365:
8522:
7754:
7739:"COVID-19 associated Kawasaki-like multisystem inflammatory syndrome in an adult"
7291:
5870:
5506:
5204:
Alves NR, Magalhães CM, Almeida R, Santos RC, Gandolfi L, Pratesi R (June 2011).
4091:
4074:
3872:
2887:
2558:
2541:
2526:
2509:
2160:
2124:
2115:
1881:
1805:
1751:
1720:
Echocardiogram may show subtle coronary artery changes or, later, true aneurysms.
1592:
1529:
1461:
1287:
1161:
1102:
1098:
1004:
913:
905:
732:
689:
445:
371:
284:
257:
91:
9309:
9132:
Cardiovascular Rheumatic Diseases, An Issue of Rheumatic Disease Clinics, E-Book
6813:"Understanding SARS-CoV-2-related multisystem inflammatory syndrome in children"
3765:
Do HJ, Baek JG, Kim HJ, Yeom JS, Park JS, Park ES, et al. (November 2009).
3277:
3260:
2808:
2618:
1482:
Fever of ≥5 days' duration associated with at least four† of these five changes
826:
9388:
Yamamoto T, Oya T, Watanabe A (1968). "Clinical features of Kawasaki disease".
7634:
7450:
7422:
7405:
7065:
Proceedings of the National Academy of Sciences of the United States of America
6768:
Freeman AF, Shulman ST (June 2001). "Recent developments in Kawasaki disease".
6647:
6630:
6387:
6370:
6318:
Carlton-Conway D, Ahluwalia R, Henry L, Michie C, Wood L, Tulloh R (May 2005).
6066:
Ichiyama T, Nishikawa M, Hayashi T, Koga M, Tashiro N, Furukawa S (July 1998).
5905:
5609:
5445:
5428:
4221:
4204:
3782:
2872:"Lifetime cardiovascular management of patients with previous Kawasaki disease"
2758:
2451:
Echocardiography in Pediatric and Congenital Heart Disease: From Fetus to Adult
2176:
1873:
1829:
1673:
1488:
1398:
1338:
1198:
1179:
1037:
909:
503:
402:
327:
300:
283:
While the specific cause is unknown, it is thought to result from an excessive
195:
158:
9681:
9633:
9099:
8275:
8260:"Intravenous immunoglobulin for the treatment of Kawasaki disease in children"
8192:
8157:
8005:
7139:
6879:
6829:
5258:
4411:
4328:
4043:
3328:
3191:
2708:
2411:
9990:
9580:
8751:
8325:
8308:
7684:"Multisystem inflammatory syndrome in children and adolescents with COVID-19"
7473:
6542:
6084:
6067:
5309:
5292:
4824:
4807:
4132:
4115:
2104:
2086:
1997:
1977:
1965:
1877:
1853:
1833:
1600:
1302:
1294:
1271:
1228:
1187:
1173:
811:
760:
555:
304:
170:
9531:
9515:
9177:
8972:
7907:
7890:
7372:
7085:
6736:
6593:
6255:
6188:
Wright H, Waddington C, Geddes J, Newburger JW, Burgner D (September 2008).
5694:
5677:
5654:
5349:
4868:
4851:
4668:
4651:
4257:
3582:"Oral necrotizing microvasculitis in a patient affected by Kawasaki disease"
3237:
2186:
Rarely, recurrence can occur in Kawasaki disease with or without treatment.
1903:
931:
returns to normal, usually at six to eight weeks after the onset of illness.
9860:
9539:
9277:
9269:
9186:
9107:
9064:
9022:
8980:
8936:
8769:
8712:
8671:
8628:
8592:
8541:
8452:
8401:
8392:
8375:
8334:
8293:
8200:
8165:
8130:
8099:
8050:
8023:
7952:
7916:
7875:
7824:
7805:
7772:
7652:
7603:
7554:
7489:
7431:
7390:
7309:
7260:
7158:
7104:
7045:
6952:
6887:
6848:
6789:
6754:
6705:
6656:
6612:
6561:
6449:
6396:
6369:
King WJ, Schlieper A, Birdi N, Cappelli M, Korneluk Y, Rowe PC (May 2000).
6355:
6336:
6304:
6263:
6213:
6205:
6166:
6049:
6041:
5952:
5878:
5843:
5738:
5703:
5662:
5627:
5578:
5514:
5495:
5454:
5402:
5367:
5266:
5231:
5094:
4704:
4581:
4429:
4347:
4265:
4230:
4100:
4051:
4016:
3981:
3939:
3890:
3841:
3800:
3666:
3600:
3555:
3490:
3412:
3385:
3346:
3245:
3199:
2905:
2827:
2776:
2727:
2665:
2614:
2567:
2535:
2429:
2060:
1897:
1658:
A physical examination will demonstrate many of the features listed above.
1584:
1512:
1361:
1279:
1191:
1118:
1067:
924:
795:
767:, and normally observed up to the fifth day of fever. However, it is never
719:
711:
575:
515:
375:
322:
Typically, initial treatment of Kawasaki disease consists of high doses of
265:
253:
74:
9428:
9420:
9072:
8901:
8866:
8831:
8804:
6687:
6131:
6093:
6014:
5979:
5913:
5808:
5773:
5524:. If this is an intentional citation to a retracted paper, please replace
5318:
5206:"Prospective study of Kawasaki disease complications: review of 115 cases"
5173:
5130:
5055:
5028:
4987:
4952:
4917:
4877:
4833:
4785:
4739:
4677:
4636:
4589:
4542:
4499:
4464:
4377:
4181:
4141:
3751:
3701:
3693:
3517:
3447:
3286:
3164:
3121:
3061:
3017:
2935:
1368:
ubiquitous virus, possibly one that enters through the respiratory tract.
1297:, can include attention deficits, learning deficits, emotional disorders (
985:
9700:
9201:
8996:"The role of coronary bypass operation on children with Kawasaki disease"
8703:
8686:
8663:
5927:
Tabarki B, Mahdhaoui A, Selmi H, Yacoub M, Essoussi AS (September 2001).
5730:
3921:
2999:
2097:
is required, as these infections are most likely to cause Reye syndrome.
1849:
1825:
1761:
1745:
1731:
1604:
1565:
1375:
1371:
1365:
1330:
1146:
1063:
807:
787:
715:
667:
599:
579:
571:
527:
387:
363:
277:
142:
95:
6431:
3364:[Incidence and clinical characteristics of Kawasaki's disease].
1836:
toxin-mediated diseases such as scarlet fever and toxic shock syndrome;
9722:
9485:
9471:
8374:
Hsieh KS, Weng KP, Lin CC, Huang TC, Lee CL, Huang SM (December 2004).
6864:"A Comprehensive Update on Kawasaki Disease Vasculitis and Myocarditis"
6670:
Nakamura Y, Yashiro M, Uehara R, Oki I, Watanabe M, Yanagawa H (2008).
5966:
Takagi K, Umezawa T, Saji T, Morooka K, Matsuo N (September 1990). "".
4534:
4491:
4309:
2081:
2074:
2056:
1973:
1949:
1913:
1885:
1821:
1737:
1723:
1591:, together with laboratory findings. Timely diagnosis requires careful
1457:
1374:
in the appearance of new cases of Kawasaki disease have been linked to
1255:
1243:
1240:
1194:
1059:
1041:
992:
981:
940:
843:
779:
681:
595:
559:
460:
426:
340:
249:
185:
78:
70:
9761:
9616:
6995:
6934:
6237:"Sensorineural hearing loss and Kawasaki disease: a prospective study"
5929:"Kawasaki disease with predominant central nervous system involvement"
5787:
Burke MJ, Rennebohm RM (1981). "Eye involvement in Kawasaki disease".
2047:). This form of categorization is relevant for appropriate treatment.
9711:
8117:[Primary childhood vasculitis--new classification criteria].
6966:
Ballester J, Burns JC, Cayan D, Nakamura Y, Uehara R, Rodó X (2013).
6295:
6279:"[Sensorineural hearing loss associated to Kawasaki Disease]"
6278:
4852:"Regression of coronary aneurysms in patients with Kawasaki syndrome"
4205:"Not just coronary arteritis, Kawasaki disease is a myocarditis, too"
3052:
3035:
2094:
2090:
1985:
1453:
1357:
1326:
1202:
936:
890:
886:
865:
The course of the disease can be divided into three clinical phases.
815:
783:
748:
523:
367:
288:
202:
8726:
Green, Jessica; Wardle, Andrew J.; Tulloh, Robert Mr (27 May 2022).
7967:"necrotizing vasculitis – definition of necrotizing vasculitis"
7036:
7011:
5070:
3362:"Incidencia y características clínicas de la enfermedad de Kawasaki"
1784:
guidelines state that Kawasaki disease "should be considered in the
9744:
8728:"Corticosteroids for the treatment of Kawasaki disease in children"
7242:
5822:
Anand S, Yang YC (2004). "Optic disc changes in Kawasaki disease".
5001:
Gidding SS, Shulman ST, Ilbawi M, Crussi F, Duffy CE (April 1986).
2147:
1993:
1981:
1945:
1917:
1630:
1626:
criteria must be met to establish the diagnosis. The criteria are:
1576:
1379:
are themselves modulated by seasonal and interannual events in the
1349:
1291:
1263:
1247:
1225:
1209:. It can also be found as necrotizing vasculitis, progressing into
1075:
1058:, are often observed in the acute phase of Kawasaki disease due to
1033:
1013:
901:
855:
851:
791:
756:
693:
677:
635:
631:
615:
607:
603:
507:
495:
464:
442:
316:
241:
99:
52:
9490:"Cases of morbid anatomy: aneurysms of coronary arteries in a boy"
8557:"TNF-α blockers for the treatment of Kawasaki disease in children"
8554:
7743:
Revista Española de Anestesiología y Reanimación (English Edition)
6317:
5856:
4564:
Durongpisitkul K, Gururaj VJ, Park JM, Martin CF (December 1995).
3767:"Kawasaki disease presenting as parotitis in a 3-month-old infant"
2035:, unlike other vasculitic disorders associated with them (such as
248:
and mainly affects children under 5 years of age. It is a form of
8115:"Primær vaskulitis i barnealderen – nye klassifikationskriterier"
6911:"Association of Kawasaki disease with tropospheric wind patterns"
3816:"Quadro/Chart 3: Secondary clinical findings of Kawasaki disease"
3142:
2320:
Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007).
2171:
1817:
1801:
1588:
1569:
1306:
1236:
1183:
1142:
996:
947:
859:
768:
743:
539:
395:
323:
261:
191:
9659:
9226:
6277:
Silva CH, Roscoe IC, Fernandes KP, Novaes RM, Lázari CS (2002).
1856:. Infectious conditions that can mimic Kawasaki disease include
1537:
Disease cannot be explained by some other known disease process
9883:
9869:
9628:
9601:
8684:
8257:
6187:
4563:
4477:
3468:
1768:
1741:
1410:
1275:
1097:
aneurysm, with a higher number of reported cases involving the
1094:
1078:
1051:
1029:
847:
430:
415:
220:
9086:
Saha A, Sarkar S (August 2018). "Recurrent Kawasaki Disease".
8417:"Salicylate for the treatment of Kawasaki disease in children"
7576:
Phuong LK, Bonetto C, Buttery J, et al. (December 2016).
7322:
5640:
3725:"Hydrops of the gallbladder associated with Kawasaki syndrome"
3723:
Suddleson EA, Reid B, Woolley MM, Takahashi M (October 1987).
9406:
8072:
Brandt HR, Arnone M, Valente NY, Sotto MN, Criado PR (2009).
7274:
Galeotti C, Kaveri SV, Cimaz R, Koné-Paut I, Bayry J (2016).
6631:"A framework for understanding Kawasaki disease pathogenesis"
6109:
4649:
3722:
3679:
3258:
2507:
2183:
that persists beyond the clinical resolution of the disease.
1928:, and "multisystem inflammatory syndrome in children" by the
1561:
1508:
1507:
One or more changes of the arms and legs, including redness,
1440:
1428:
1416:
1344:
Circumstantial evidence points to an infectious cause. Since
1130:
916:
aneurysms usually develop during this time, and the risk for
839:
245:
8306:
7969:. Free Online Medical Dictionary, Thesaurus and Encyclopedia
7273:
7058:
6065:
5041:
2024:
1499:, including throat redness, dry cracked lips, red lips, and
6965:
6409:
6235:
Knott PD, Orloff LA, Harris JP, Novak RE, Burns JC (2001).
5926:
5427:
Cheung YF, Yung TC, Tam SC, Ho MH, Chau AK (January 2004).
5203:
5151:
3903:
3857:"Periungual desquamation in patients with Kawasaki disease"
1771:
is rarely performed, as it is not necessary for diagnosis.
1521:
1434:
1267:
976:
764:
723:
354:
8782:
8649:
7837:
6371:"The effect of Kawasaki disease on cognition and behavior"
6368:
6276:
6144:
5751:
5716:
5470:"Arterial hemodynamics in patients after Kawasaki disease"
5380:
5000:
4442:
4243:
4113:
3904:
Michie C, Kinsler V, Tulloh R, Davidson S (October 2000).
3099:
2790:
Abrams JY, Godfred-Cato SE, Oster ME, et al. (2020).
9050:
8817:
7718:. Centers for Disease Control and Prevention. 15 May 2020
5467:
5290:
5068:
4159:
3997:"Enfermedad de Kawasaki: presentación de cincuenta casos"
3579:
3533:
2692:"Autoimmune and inflammatory diseases following COVID-19"
2358:, The Royal College of Paediatrics and Child Health, 2020
1904:
Kawasaki-like disease temporally associated with COVID-19
9516:"History of the worldwide emergence of Kawasaki disease"
8605:
8143:
8071:
8039:
European Review for Medical and Pharmacological Sciences
7227:"Kawasaki Disease: Global Burden and Genetic Background"
7123:"Dissecting Kawasaki disease: a state-of-the-art review"
6908:
6669:
6482:
5965:
4930:
4363:
2003:
Other diseases involving necrotizing vasculitis include
1456:
also seem to affect susceptibility and prognosis. At an
7987:
7785:
7472:
Shulman, Stanford T.; Taubert, Kathryn A. (June 1999).
7403:
7323:
Behrman RE, Kliegman R, Marcdante K, Jenson HB (2006).
6577:"The Epidemiology and Pathogenesis of Kawasaki Disease"
4520:
4116:"Diagnosis and therapy of Kawasaki disease in children"
3398:
2789:
7988:
Dillon MJ, Eleftheriou D, Brogan PA (September 2010).
7354:
7121:
Dietz SM, van Stijn D, Burgner D, et al. (2017).
6456:
6234:
6068:"Cerebral hypoperfusion during acute Kawasaki disease"
6027:
5107:
4691:
Kobayashi T, Inoue Y, Morikawa A (February 2008). "".
4690:
3425:
3223:
2741:
Lin J, Harahsheh AS, Raghuveer G, et al. (2023).
830:
Signs and symptoms and time course of Kawasaki disease
390:. However, when appropriate therapy is started –
8844:
8414:
7120:
6861:
6320:"Behaviour sequelae following acute Kawasaki disease"
5891:
5293:"Endothelial dysfunction late after Kawasaki disease"
4805:
2740:
1740:
may show white blood cells and protein in the urine (
1645:
swollen lymph node in the neck of at least 15 mm
9606:
9560:
7575:
5675:
4895:
46:
Kawasaki syndrome, mucocutaneous lymph node syndrome
9387:
7224:
6968:"Kawasaki disease and ENSO-driven wind circulation"
4849:
4693:
Nihon Rinsho. Japanese Journal of Clinical Medicine
4393:
3906:"Recurrent skin peeling following Kawasaki disease"
3814:Castro, P. A.; Urbano, L. M.; Costa, I. M. (2009).
3503:
2870:Brogan P, Burns JC, Cornish J, et al. (2020).
2447:
2213:In Japan, the rate is 240 in every 100,000 people.
1495:One or more changes of the mucous membranes of the
8957:
8914:
8496:Kuo HC, Lo MH, Hsieh KS, Guo MM, Huang YH (2015).
7316:
7225:Elakabawi K, Lin J, Jiao F, Guo N, Yuan Z (2020).
6190:"Facial nerve palsy complicating Kawasaki disease"
5678:"Intestinal pseudoobstruction in Kawasaki disease"
5244:
4965:
2869:
2637:de Graeff N, Groot N, Ozen S, et al. (2019).
2636:
2454:(2 ed.). John Wiley & Sons. p. 739.
1694:may show evidence of hepatic inflammation and low
1633:of the lips or oral cavity or cracking of the lips
1622:Classically, five days of fever plus four of five
1555:Source: Nelson's essentials of pediatrics, Review
706:In the acute phase of the disease, changes in the
60:A medical illustration depicting Kawasaki disease.
9449:
8725:
8373:
7888:
7220:
7218:
7216:
7214:
6523:
5859:Journal of Pediatric Ophthalmology and Strabismus
5824:Journal of Pediatric Ophthalmology and Strabismus
5789:Journal of Pediatric Ophthalmology and Strabismus
4763:
3999:[Kawasaki disease: A report of 50 cases]
3813:
3638:
3036:"General review and problems in Kawasaki disease"
1844:); systemic onset juvenile idiopathic arthritis;
9988:
8253:
8251:
7938:
7934:
7932:
7930:
7928:
7926:
7350:
7348:
7346:
7344:
7175:Son, MB; Sundel, RP (2016). "Kawasaki Disease".
6375:Archives of Pediatrics & Adolescent Medicine
5556:
4850:Takahashi M, Mason W, Lewis AB (February 1987).
3634:
3632:
3630:
2845:"Merck Manual, Online edition: Kawasaki Disease"
2107:(TNF-α) may reduce treatment resistance and the
738:The most common skin manifestation is a diffuse
6519:
6517:
6515:
6513:
6511:
5594:"A case of Kawasaki disease with colonic edema"
5426:
5422:
5420:
5199:
5197:
5195:
5193:
5191:
4389:
4387:
4305:
4303:
4301:
3951:
3949:
3628:
3626:
3624:
3622:
3620:
3618:
3616:
3614:
3612:
3610:
3575:
3573:
3529:
3527:
3306:
3304:
3302:
3300:
3298:
3296:
3219:
3217:
2977:
2975:
2973:
2971:
2969:
2967:
2965:
2685:
2683:
1018:the heart not receiving enough blood and oxygen
335:cardiological monitoring by specialized teams.
8879:
8074:"[Medium and large vessel vasculitis]"
7882:
7532:
7471:
7397:
7211:
6767:
6761:
6105:
6103:
6061:
6059:
5786:
5676:Akikusa JD, Laxer RM, Friedman JN (May 2004).
5286:
5284:
4891:
4889:
4887:
4845:
4843:
4801:
4799:
4797:
4795:
4759:
4757:
4359:
4357:
4155:
4153:
4151:
3639:Castro PA, Urbano LM, Costa IM (August 2009).
3029:
3027:
2963:
2961:
2959:
2957:
2955:
2953:
2951:
2949:
2947:
2945:
2917:
2915:
9890:Eosinophilic granulomatosis with polyangiitis
9777:
9509:
9507:
8987:
8951:
8908:
8678:
8643:
8495:
8489:
8467:"Kawasaki Disease Treatment & Management"
8367:
8300:
8248:
8220:
8218:
8172:
8137:
8112:
8065:
8030:
7981:
7923:
7569:
7526:
7410:Journal of the American College of Cardiology
7341:
7267:
7116:
7114:
6721:"Is Kawasaki disease an infectious disorder?"
6663:
6574:
5433:Journal of the American College of Cardiology
5007:Journal of the American College of Cardiology
4280:"Clinical manifestations of Kawasaki disease"
4209:Journal of the American College of Cardiology
3960:[Beau's lines and Kawasaki disease].
3854:
3764:
3589:Medicina Oral, Patologia Oral y Cirugia Bucal
2981:
2689:
2448:Lai WW, Mertens LL, Cohen MS, Geva T (2015).
2045:eosinophilic granulomatosis with polyangiitis
2017:eosinophilic granulomatosis with polyangiitis
1926:Royal College of Paediatrics and Child Health
782:) and swelling, frequently symmetrical, and
313:Multisystem inflammatory syndrome in children
9565:. Vol. 1093. Elsevier. pp. 34–38.
9400:
9149:
9044:
8873:
8838:
8820:Progress in Clinical and Biological Research
8811:
8776:
8178:
7665:: CS1 maint: multiple names: authors list (
7446:"Kawasaki disease – Diagnosis and treatment"
7404:Newburger JW, Takahashi M, Burns JC (2016).
6712:
6508:
6403:
6362:
6311:
6270:
6228:
6181:
6138:
6021:
5920:
5850:
5815:
5710:
5669:
5634:
5585:
5550:
5461:
5417:
5374:
5331:
5325:
5238:
5188:
5062:
4684:
4614:
4394:Wolff AE, Hansen KE, Zakowski L (May 2007).
4384:
4298:
4237:
4196:
4066:
4023:
3988:
3946:
3897:
3848:
3758:
3607:
3570:
3524:
3462:
3392:
3353:
3293:
3214:
3171:
3079:(3rd ed.). Saunders. pp. 365–422.
3074:
2680:
2600:
2596:
2594:
2592:
1393:exact genetic contribution remains unknown.
437:" appearance (marked redness with prominent
386:and does not cease with the introduction of
315:, a "Kawasaki-like" disease associated with
179:paediatric multisystem inflammatory syndrome
9520:International Journal of Rheumatic Diseases
9165:International Journal of Rheumatic Diseases
8732:The Cochrane Database of Systematic Reviews
8561:The Cochrane Database of Systematic Reviews
8421:The Cochrane Database of Systematic Reviews
8264:The Cochrane Database of Systematic Reviews
7706:
7704:
7678:
7676:
7170:
7168:
6804:
6725:International Journal of Rheumatic Diseases
6568:
6100:
6056:
5986:
5959:
5885:
5780:
5745:
5281:
5145:
5101:
5035:
4994:
4959:
4924:
4884:
4840:
4792:
4754:
4711:
4643:
4608:
4557:
4514:
4471:
4436:
4396:"Acute Kawasaki disease: not just for kids"
4354:
4148:
4107:
3716:
3673:
3497:
3419:
3310:
3252:
3136:
3093:
3075:Cassidy JT, Petty RE (1995). "Vasculitis".
3024:
2942:
2912:
2632:
2630:
2628:
2285:
2283:
2281:
2279:
2277:
2275:
2273:
2271:
2269:
2267:
2265:
398: – the fever subsides after two days.
9784:
9770:
9504:
9128:
9085:
8215:
7111:
6959:
6624:
6622:
6526:"How Should We Classify Kawasaki Disease?"
5538:|...|intentional=yes}}
5332:Cheung YF, Wong SJ, Ho MH (January 2007).
5071:"Aortic root dilation in Kawasaki disease"
2863:
2839:
2837:
2783:
2503:
2501:
2499:
2497:
2495:
2389:
2387:
2385:
2263:
2261:
2259:
2257:
2255:
2253:
2251:
2249:
2247:
2245:
2198:. Incidence rates vary between countries.
1930:Centers for Disease Control and Prevention
1515:around the nails, and generalized peeling
51:
9443:
9361:"Kawasaki disease in kids at record high"
9344:
9219:
9176:
8759:
8702:
8582:
8572:
8531:
8521:
8442:
8432:
8391:
8324:
8283:
8089:
8013:
7939:Guillevin L, Pagnoux C (March 2008). "".
7906:
7865:
7855:
7814:
7804:
7762:
7642:
7593:
7421:
7380:
7299:
7250:
7202:
7174:
7148:
7138:
7094:
7084:
7035:
7012:"Infectious disease: Blowing in the wind"
6994:
6942:
6862:Soni PR, Noval Rivas M, Arditi M (2020).
6855:
6838:
6828:
6744:
6695:
6646:
6602:
6592:
6551:
6541:
6439:
6386:
6345:
6335:
6294:
6083:
5821:
5693:
5617:
5485:
5444:
5357:
5308:
5221:
5018:
4867:
4823:
4667:
4419:
4337:
4327:
4220:
4131:
4090:
4029:
3958:"Líneas de Beau y enfermedad de Kawasaki"
3929:
3880:
3831:
3790:
3656:
3336:
3313:"Associated symptoms of kawasaki disease"
3276:
3051:
3007:
2895:
2817:
2807:
2766:
2717:
2707:
2589:
2557:
2525:
2493:
2491:
2489:
2487:
2485:
2483:
2481:
2479:
2477:
2475:
2419:
2383:
2381:
2379:
2377:
2375:
2373:
2371:
2369:
2367:
2365:
2345:
2343:
2341:
1811:
1639:swelling or erythema of the hands or feet
9452:American Journal of Diseases of Children
9135:. Elsevier Health Sciences. p. 66.
8993:
7736:
7701:
7673:
7165:
6030:European Journal of Paediatric Neurology
4079:The Pediatric Infectious Disease Journal
3861:The Pediatric Infectious Disease Journal
3506:The Pediatric Infectious Disease Journal
3033:
2921:
2625:
2443:
2441:
2439:
1560:
957:
825:
353:
9791:
9155:
8036:
7003:
6619:
6414:, Orenstein JM, Shulman ST (May 2008).
5210:Revista da Associação Médica Brasileira
3855:Wang S, Best BM, Burns JC (June 2009).
3536:Journal of Paediatrics and Child Health
2834:
2601:Modesti, AM; Plewa, MC (24 July 2019).
2468:from the original on 11 September 2017.
2313:
2242:
1748:) without evidence of bacterial growth.
1401:have together helped identify specific
1074:caused by thickening or deformation of
14:
9989:
9326:
9255:
8113:Herlin T, Nielsen S (September 2008).
7508:"Kawasaki Disease Diagnostic Criteria"
7009:
6810:
6770:Current Opinion in Infectious Diseases
6718:
5968:No to Hattatsu = Brain and Development
5591:
4717:
4202:
3311:Yun SH, Yang NR, Park SA (July 2011).
2472:
2362:
2338:
2324:. St. Louis: Mosby. pp. 1232–34.
2301:from the original on 11 September 2017
2142:complications of coronary vasculitis.
2033:anti-neutrophil cytoplasmic antibodies
1730:may show hydrops (enlargement) of the
1290:are thought to be caused by localised
763:were reported. It can be polymorphic,
441:). These mouth symptoms are caused by
10027:Vascular-related cutaneous conditions
9765:
9513:
9298:from the original on 9 February 2011.
7793:Morbidity and Mortality Weekly Report
6524:Marrani E, Burns JC, Cimaz R (2018).
6496:from the original on 12 December 2008
6470:from the original on 29 December 2008
2580:
2436:
2297:. NHLBI Health Topics. 11 June 2014.
2153:percutaneous transluminal angioplasty
1532:in the neck (>15 mm in size)
349:
319:, appears to have distinct features.
10017:Systemic connective tissue disorders
9464:10.1001/archpedi.1976.02120070025006
7327:. St. Louis, Mo: Elsevier Saunders.
6902:
5992:
4400:Journal of General Internal Medicine
4075:"Pustular rash in Kawasaki syndrome"
1920:, emerged in the US and Europe. The
1890:staphylococcal scalded skin syndrome
1804:safety monitoring, an international
984:in a coronary artery aneurysm or to
735:), and occasionally nails are shed.
9484:
8691:The New England Journal of Medicine
6635:Clinical Immunology (Orlando, Fla.)
3265:The New England Journal of Medicine
2982:Rowley AH, Shulman ST (July 1998).
2851:from the original on 2 January 2010
2393:
904:phase begins when fever, rash, and
244:of unknown cause that results in a
215:8–124 per 100,000 people under five
24:
9936:Acute hemorrhagic edema of infancy
9158:"The genetics of Kawasaki disease"
8847:The American Journal of Cardiology
8785:The American Journal of Cardiology
7514:from the original on 7 August 2016
7185:10.1016/B978-0-323-24145-8.00035-1
7177:Textbook of Pediatric Rheumatology
6628:
6244:American Journal of Otolaryngology
5487:10.1161/01.CIR.0000162483.51132.25
5166:10.1111/j.1442-200X.1995.tb03368.x
5123:10.1111/j.1442-200X.1996.tb03480.x
5075:The American Journal of Cardiology
5044:The Journal of Heart Valve Disease
4933:The American Journal of Cardiology
4732:10.1111/j.1442-200X.1991.tb02612.x
4286:from the original on 20 April 2012
4174:10.1111/j.1440-1827.1986.tb03119.x
3114:10.1111/j.1651-2227.1994.tb12985.x
3077:Textbook of pediatric rheumatology
1795:
346:, who first described it in 1967.
295:to those infections. It is not an
25:
10043:
9951:Cutaneous small-vessel vasculitis
9915:Cutaneous small-vessel vasculitis
9591:
9316:from the original on 26 May 2004.
9310:"Rare heart disease rate doubles"
9237:from the original on 12 July 2014
8078:Anais Brasileiros de Dermatologia
7889:McCrindle BW, Manlhiot C (2020).
7496:from the original on 17 May 2008.
5754:American Journal of Ophthalmology
5598:Journal of Korean Medical Science
4215:(14): 1507, author reply 1507–8.
3820:Anais Brasileiros de Dermatologia
3645:Anais Brasileiros de Dermatologia
3471:American Journal of Ophthalmology
1939:
1820:and other viral infections (e.g.
1653:
1642:red eyes (conjunctival injection)
1305:), and internalization problems (
975:Even when treated with high-dose
893:are generally not yet visible by
238:mucocutaneous lymph node syndrome
10032:Diseases named after discoverers
9876:Granulomatosis with polyangiitis
9554:
9478:
9381:
9353:
9346:10.1093/rheumatology/keaa111.129
9320:
9302:
9284:
9249:
9122:
9079:
9015:10.1097/00019501-200212000-00009
8929:10.1046/j.1442-200X.2001.01464.x
8719:
8599:
8548:
8459:
8408:
8341:
8106:
7959:
7831:
7779:
7730:
7610:
7547:10.1111/j.1651-2227.2010.01875.x
7500:
7438:
7361:Annals of the Rheumatic Diseases
7052:
6782:10.1097/00001432-200106000-00017
5395:10.1111/j.1442-200x.2004.01929.x
5338:Archives of Disease in Childhood
3910:Archives of Disease in Childhood
3548:10.1111/j.1440-1754.2008.01310.x
3440:10.1097/00006454-198505000-00010
2037:granulomatosis with polyangiitis
2009:granulomatosis with polyangiitis
1064:inflammation of the heart muscle
946:Some children, especially young
256:. Other common symptoms include
9946:Bullous small vessel vasculitis
9327:Rutter, Megan (20 April 2020).
9129:Brasington, Richard D. (2014).
8091:10.1590/S0365-05962009000100008
7990:"Medium-size-vessel vasculitis"
7325:Nelson essentials of pediatrics
4272:
3833:10.1590/S0365-05962009000400002
3807:
3658:10.1590/S0365-05962009000400002
3068:
2734:
2189:
1988:by the occurrence of necrosis (
1403:single nucleotide polymorphisms
1395:Genome-wide association studies
1329:that triggers an inappropriate
1060:inflammation of the heart valve
1024:adults. The main symptoms were
27:Disease found in young children
9292:"BBC Health: Kawasaki Disease"
8744:10.1002/14651858.CD011188.pub3
8574:10.1002/14651858.CD012448.pub2
8434:10.1002/14651858.CD004175.pub2
8226:"Who Kawasaki Disease Affects"
7737:Elouardi, Y (7 January 2022).
7127:European Journal of Pediatrics
6575:Rowley AH, Shulman ST (2018).
6466:. American Heart Association.
6159:10.1016/j.braindev.2005.04.003
5592:Kim MY, Noh JH (August 2008).
5571:10.1016/j.jpedsurg.2005.05.063
4480:European Journal of Pediatrics
4032:European Journal of Pediatrics
2574:
1800:For study purposes, including
1713:dysfunction or, occasionally,
1702:Other optional tests include:
1680:Erythrocyte sedimentation rate
13:
1:
8894:10.1016/S0022-3476(87)80246-9
8797:10.1016/S0002-9149(98)00116-7
8621:10.1016/S0140-6736(18)32003-8
8080:(in English and Portuguese).
7857:10.1016/S0140-6736(20)31526-9
7595:10.1016/j.vaccine.2016.09.025
6285:(in English and Portuguese).
5945:10.1016/S0887-8994(01)00290-9
5836:10.3928/0191-3913-20040501-12
5801:10.3928/0191-3913-19810901-04
5223:10.1016/s2255-4823(11)70062-5
5087:10.1016/S0002-9149(00)01541-1
5020:10.1016/S0735-1097(86)80354-0
4910:10.1016/S0022-3476(86)80928-3
4778:10.1016/S0022-3476(86)80878-2
4629:10.1016/S0022-3476(97)70038-6
4457:10.1016/S0022-3476(86)80689-8
4316:Italian Journal of Pediatrics
4005:Anales Espanoles de Pediatria
3974:10.1016/s1695-4033(07)70817-2
3744:10.1016/S0022-3468(87)80600-0
3483:10.1016/S0002-9394(99)00285-8
3378:10.1016/S1695-4033(03)78190-9
3157:10.1016/S0022-3476(87)80503-6
2988:Clinical Microbiology Reviews
2922:Kawasaki T (March 1967). "".
2235:
1609:juvenile idiopathic arthritis
1333:cascade in a small number of
1170:intestinal pseudo-obstruction
536:intestinal pseudo-obstruction
374:, and is followed by extreme
309:juvenile rheumatoid arthritis
207:Mortality 0.2% with treatment
175:juvenile rheumatoid arthritis
9088:Indian Journal of Pediatrics
8994:Kitamura S (December 2002).
8859:10.1016/0002-9149(85)90767-2
8523:10.1371/journal.pone.0144603
8181:Current Rheumatology Reports
7755:10.1016/j.redare.2020.11.009
7292:10.1016/j.drudis.2016.08.004
6975:Geophysical Research Letters
6868:Current Rheumatology Reports
6420:Nature Reviews. Microbiology
6124:10.1016/0887-8994(92)90077-C
6007:10.1016/0090-3019(88)90009-2
5894:Clinical Infectious Diseases
5871:10.3928/01913913-20070901-06
5766:10.1016/0002-9394(82)90465-2
5643:Journal of Pediatric Surgery
5559:Journal of Pediatric Surgery
5507:10.1161/CIR.0b013e31825f6499
4980:10.1016/0002-8703(90)90081-8
4945:10.1016/0002-9149(88)90950-2
4092:10.1097/INF.0b013e31814619ec
3873:10.1097/INF.0b013e3181945984
3732:Journal of Pediatric Surgery
3641:"[Kawasaki disease]"
3428:Pediatric Infectious Disease
2888:10.1136/heartjnl-2019-315925
2696:Nature Reviews. Rheumatology
2690:Galeotti C, Bayry J (2020).
2559:10.1161/CIR.0000000000000703
2527:10.1161/CIR.0000000000000484
2131:
2050:
1916:, the virus responsible for
1846:Rocky Mountain spotted fever
1467:
1381:El Niño–Southern Oscillation
1274:involvement are reported as
710:can include erythema of the
268:, or soles of the feet, and
7:
9941:Cryoglobulinemic vasculitis
7623:Nature Reviews Rheumatology
3278:10.1056/NEJM199106063242305
3034:Kawasaki T (January 1995).
2809:10.1016/j.jpeds.2020.08.003
2658:10.1093/rheumatology/key344
1964:immune pathways). Overall,
1774:
1387:
477:Less common manifestations
429:may be bright red, and the
260:in the neck, a rash in the
10:
10048:
9842:Thromboangiitis obliterans
8230:Children's Hospital Boston
7635:10.1038/s41584-021-00709-9
7423:10.1016/j.jacc.2015.12.073
6817:Nature Reviews. Immunology
6648:10.1016/j.clim.2020.108385
6490:"Kawasaki Disease: Causes"
6388:10.1001/archpedi.154.5.463
5610:10.3346/jkms.2008.23.4.723
5547:due to ethical violations.
5446:10.1016/j.jacc.2003.08.030
4222:10.1016/j.jacc.2009.11.067
3783:10.4070/kcj.2009.39.11.502
3771:Korean Circulation Journal
3317:Korean Circulation Journal
3180:Rheumatology International
2759:10.1016/j.cjca.2023.01.002
2219:
2071:Intravenous immunoglobulin
1894:toxic epidermal necrolysis
1782:American Heart Association
1397:and studies of individual
1284:sensorineural hearing loss
953:
392:intravenous immunoglobulin
9997:Ailments of unknown cause
9963:
9928:
9907:Type III hypersensitivity
9905:
9859:
9850:
9822:
9799:
9691:
9610:
9494:St Bartholomew's Hosp Rep
9100:10.1007/s12098-017-2567-y
8961:The Journal of Pediatrics
8882:The Journal of Pediatrics
8652:The Journal of Pediatrics
8276:10.1002/14651858.CD004000
8193:10.1007/s11926-000-0044-4
8158:10.1016/j.lpm.2007.01.035
8006:10.1007/s00467-009-1336-1
7484:(11): 3093–102, 3107–08.
7478:American Family Physician
7140:10.1007/s00431-017-2937-5
6880:10.1007/s11926-020-0882-1
6830:10.1038/s41577-020-0367-5
5719:The Journal of Pediatrics
5259:10.1007/s00246-008-9296-y
5154:Acta Paediatrica Japonica
5111:Acta Paediatrica Japonica
4898:The Journal of Pediatrics
4766:The Journal of Pediatrics
4720:Acta Paediatrica Japonica
4617:The Journal of Pediatrics
4445:The Journal of Pediatrics
4412:10.1007/s11606-006-0100-5
4329:10.1186/s13052-018-0536-3
4246:The Journal of Pediatrics
4044:10.1007/s00431-005-1715-y
3329:10.4070/kcj.2011.41.7.394
3226:The Journal of Pediatrics
3192:10.1007/s00296-011-2123-4
3145:The Journal of Pediatrics
2796:The Journal of Pediatrics
2709:10.1038/s41584-020-0448-7
2609:. StatPearls Publishing.
2412:10.3349/ymj.2006.47.6.759
2322:Dermatology: 2-Volume Set
1922:World Health Organization
1487:Bilateral nonsuppurative
1320:
1207:ocular artery obstruction
699:
476:
403:conjunctival inflammation
358:Signs of Kawasaki disease
274:coronary artery aneurysms
219:
211:
201:
184:
164:
151:
141:
133:
125:
117:
112:Coronary artery aneurysms
105:
84:
64:
59:
50:
42:
37:
9895:Microscopic polyangiitis
9739:Disease Kawasaki Disease
9213:ucsfbenioffchildrens.org
8917:Pediatrics International
8326:10.1542/peds.2022-059175
6543:10.3389/fimmu.2018.02974
6085:10.1161/01.STR.29.7.1320
5906:10.1093/clinids/14.1.121
5383:Pediatrics International
5310:10.1161/01.cir.94.9.2103
4825:10.1161/01.cir.94.6.1379
4133:10.1161/01.CIR.87.5.1776
2585:. StatPearls Publishing.
2394:Kim DS (December 2006).
2157:coronary artery stenting
2041:microscopic polyangiitis
2013:Henoch–Schönlein purpura
1956:disease (i.e. involving
1842:Stevens Johnson syndrome
1356:infection by some novel
1154:Henoch–Schönlein purpura
1088:
1048:Valvular insufficiencies
456:Cervical lymphadenopathy
9532:10.1111/1756-185X.13214
9178:10.1111/1756-185X.13218
9003:Coronary Artery Disease
8973:10.1067/mpd.2000.107164
7908:10.1001/jama.2020.10370
7373:10.1136/ard.2005.046300
7179:. pp. 467–483.e6.
7086:10.1073/pnas.1400380111
7010:Frazer J (April 2012).
6811:Rowley AH (June 2020).
6737:10.1111/1756-185X.13213
6676:Journal of Epidemiology
6594:10.3389/fped.2018.00374
6581:Frontiers in Pediatrics
6530:Frontiers in Immunology
6256:10.1053/ajot.2001.26495
6147:Brain & Development
5695:10.1542/peds.113.5.e504
5655:10.1053/jpsu.2001.22311
5350:10.1136/adc.2006.096628
4869:10.1161/01.CIR.75.2.387
4669:10.1161/01.cir.89.2.916
4366:Journal of Cardiography
4258:10.1067/mpd.2002.122469
4203:Dahdah N (April 2010).
4162:Pathology International
3238:10.1067/mpd.2000.107890
2165:cardiac transplantation
1910:a Kawasaki-like disease
1866:retropharyngeal abscess
1728:computerized tomography
1497:upper respiratory tract
1354:upper respiratory tract
1335:genetically predisposed
753:multiform-like erythema
700:Source: review, table.
301:ultrasound of the heart
293:genetically predisposed
159:ultrasound of the heart
147:Age of < 5 years old
9270:10.1542/peds.112.3.495
9065:10.1542/peds.100.4.695
8393:10.1542/peds.2004-1037
7806:10.15585/mmwr.mm6940e1
6337:10.1186/1471-2431-5-14
6206:10.1542/peds.2007-3238
6042:10.1053/ejpn.2001.0469
4968:American Heart Journal
4582:10.1542/peds.96.6.1057
3401:Casopis Lekaru Ceskych
3040:Japanese Heart Journal
2552:(5): e181–e184. 2019.
2400:Yonsei Medical Journal
2196:genetic susceptibility
1912:following exposure to
1870:cervical lymphadenitis
1858:periorbital cellulitis
1812:Differential diagnosis
1786:differential diagnosis
1580:
1476:Criteria for diagnosis
1454:Gene–gene interactions
1158:intestinal obstruction
1109:aneurysm, aneurysm of
1107:brachiocephalic artery
963:
875:conjunctival injection
831:
726:usually begins in the
708:peripheral extremities
660:influenza-like illness
644:sensorineural deafness
612:interstitial nephritis
584:valvular heart disease
469:differential diagnoses
359:
166:Differential diagnosis
9421:10.1542/peds.54.3.271
9312:. BBC. 17 June 2002.
7941:La Revue du Praticien
6688:10.2188/jea.JE2008030
5530:|...}}
5501:(Retracted, see
3694:10.1542/peds.93.3.525
2646:Rheumatology (Oxford)
1862:peritonsillar abscess
1840:reactions (including
1838:drug hypersensitivity
1754:may show evidence of
1709:may show evidence of
1564:
1301:, fear of night, and
999:concentrations, high
969:acute rheumatic fever
961:
829:
821:myocardial infarction
412:slit-lamp examination
410:may be present under
357:
9971:Goodpasture syndrome
9832:Polyarteritis nodosa
9814:Giant cell arteritis
9809:Takayasu's arteritis
9500:: 141–8, See p. 148.
8704:10.1056/NEJMoa061235
8664:10.1067/mpd.2003.191
8615:(10176): 1128–1137.
8471:Medscape – EMedicine
8119:Ugeskrift for Laeger
7994:Pediatric Nephrology
7280:Drug Discovery Today
5731:10.1067/mpd.2003.232
5247:Pediatric Cardiology
4523:Pediatric Cardiology
3922:10.1136/adc.83.4.353
3000:10.1128/CMR.11.3.405
2005:polyarteritis nodosa
1908:In 2020, reports of
1696:serum albumin levels
1692:Liver function tests
1666:Complete blood count
1597:physical examination
1579:= 6.5 mm in diameter
1548:coronary angiography
1524:, primarily truncal
1135:brachioradial artery
1072:mitral insufficiency
995:concentrations, low
982:blood clot formation
889:may be present, but
836:nonspecific symptoms
433:may have a typical "
420:Keratic precipitates
291:in children who are
10002:Autoimmune diseases
9793:Systemic vasculitis
9227:"Kawasaki Syndrome"
8514:2015PLoSO..1044603K
8236:on 23 November 2008
7231:Cardiology Research
7077:2014PNAS..111.7952R
7028:2012Natur.484...21F
6987:2013GeoRL..40.2284B
6927:2011NatSR...1E.152R
6432:10.1038/nrmicro1853
6283:Jornal de Pediatria
6112:Pediatric Neurology
5933:Pediatric Neurology
3962:Anales de Pediatria
3366:Anales de Pediatria
2984:"Kawasaki syndrome"
1717:due to myocarditis.
1617:infantile acrodynia
1501:"strawberry" tongue
1315:aggressive behavior
1246:, manifesting with
1218:meningoencephalitis
1211:peripheral gangrene
1166:intestinal ischemia
1139:high blood pressure
883:hepatic dysfunction
722:of the fingers and
656:Shortness of breath
520:hydrops gallbladder
366:(acetaminophen) or
157:Based on symptoms,
90:Fever > 5 days,
9976:Sneddon's syndrome
9692:External resources
9209:"Kawasaki Disease"
9156:Onouchi Y (2018).
8477:on 3 February 2009
8319:(5): e2022059175.
8152:(5 Pt 2): 845–53.
7474:"Kawasaki Disease"
7406:"Kawasaki Disease"
6915:Scientific Reports
6719:Rowley AH (2018).
6464:"Kawasaki Disease"
5995:Surgical Neurology
4535:10.1007/BF02315475
4492:10.1007/BF01957725
2603:"Kawasaki Disease"
2581:Owens, AM (2023).
2396:"Kawasaki disease"
2291:"Kawasaki Disease"
2105:TNF alpha blockers
2065:infectious disease
1952:process, or as an
1756:aseptic meningitis
1686:C-reactive protein
1581:
1299:emotional lability
1288:Behavioral changes
1050:, particularly of
964:
929:sedimentation rate
887:Coronary arteritis
879:aseptic meningitis
832:
804:aseptic meningitis
688:vaccination site,
640:aseptic meningitis
620:nephrotic syndrome
544:splenic infarction
450:fibrinoid necrosis
439:gustative papillae
360:
350:Signs and symptoms
297:infectious disease
10022:Vascular diseases
9984:
9983:
9959:
9958:
9759:
9758:
9514:Burns JC (2018).
9294:. 31 March 2009.
9040:on 9 August 2017.
7850:(10246): e8–e10.
7799:(40): 1450–1456.
7716:emergency.cdc.gov
6996:10.1002/grl.50388
6935:10.1038/srep00152
3647:(in Portuguese).
2520:(17): e927–e999.
2331:978-1-4160-2999-1
2109:infusion reaction
1972:Inflammation, or
1707:Electrocardiogram
1688:will be elevated.
1682:will be elevated.
1670:normocytic anemia
1636:rash on the trunk
1613:mercury poisoning
1559:
1558:
1530:Large lymph nodes
1233:cerebral ischemia
1222:subdural effusion
1083:valve replacement
728:periungual region
704:
703:
512:liver dysfunction
435:strawberry tongue
384:antipyretic drugs
344:Tomisaku Kawasaki
332:coronary arteries
258:large lymph nodes
254:usual medications
231:
230:
226:Tomisaku Kawasaki
153:Diagnostic method
92:large lymph nodes
32:Medical condition
18:Kawasaki syndrome
16:(Redirected from
10039:
9857:
9856:
9837:Kawasaki disease
9786:
9779:
9772:
9763:
9762:
9728:Kawasaki disease
9608:
9607:
9598:Kawasaki disease
9585:
9584:
9558:
9552:
9551:
9511:
9502:
9501:
9482:
9476:
9475:
9447:
9441:
9440:
9404:
9398:
9397:
9385:
9379:
9378:
9376:
9374:
9357:
9351:
9350:
9348:
9339:(Supplement_2).
9324:
9318:
9317:
9306:
9300:
9299:
9288:
9282:
9281:
9253:
9247:
9246:
9244:
9242:
9223:
9217:
9216:
9205:
9199:
9198:
9180:
9162:
9153:
9147:
9146:
9126:
9120:
9119:
9083:
9077:
9076:
9048:
9042:
9041:
9039:
9033:. Archived from
9000:
8991:
8985:
8984:
8955:
8949:
8948:
8912:
8906:
8905:
8877:
8871:
8870:
8842:
8836:
8835:
8815:
8809:
8808:
8780:
8774:
8773:
8763:
8723:
8717:
8716:
8706:
8682:
8676:
8675:
8647:
8641:
8640:
8603:
8597:
8596:
8586:
8576:
8552:
8546:
8545:
8535:
8525:
8508:(12): e0144603.
8493:
8487:
8486:
8484:
8482:
8473:. Archived from
8463:
8457:
8456:
8446:
8436:
8412:
8406:
8405:
8395:
8371:
8365:
8364:
8362:
8360:
8345:
8339:
8338:
8328:
8304:
8298:
8297:
8287:
8255:
8246:
8245:
8243:
8241:
8232:. Archived from
8222:
8213:
8212:
8176:
8170:
8169:
8141:
8135:
8134:
8110:
8104:
8103:
8093:
8069:
8063:
8062:
8034:
8028:
8027:
8017:
7985:
7979:
7978:
7976:
7974:
7963:
7957:
7956:
7936:
7921:
7920:
7910:
7886:
7880:
7879:
7869:
7859:
7835:
7829:
7828:
7818:
7808:
7783:
7777:
7776:
7766:
7734:
7728:
7727:
7725:
7723:
7708:
7699:
7698:
7696:
7694:
7680:
7671:
7670:
7664:
7656:
7646:
7614:
7608:
7607:
7597:
7573:
7567:
7566:
7535:Acta Paediatrica
7530:
7524:
7523:
7521:
7519:
7504:
7498:
7497:
7469:
7463:
7462:
7460:
7458:
7442:
7436:
7435:
7425:
7401:
7395:
7394:
7384:
7352:
7339:
7338:
7320:
7314:
7313:
7303:
7271:
7265:
7264:
7254:
7222:
7209:
7208:
7206:
7172:
7163:
7162:
7152:
7142:
7118:
7109:
7108:
7098:
7088:
7056:
7050:
7049:
7039:
7007:
7001:
7000:
6998:
6972:
6963:
6957:
6956:
6946:
6906:
6900:
6899:
6859:
6853:
6852:
6842:
6832:
6808:
6802:
6801:
6765:
6759:
6758:
6748:
6716:
6710:
6709:
6699:
6667:
6661:
6660:
6650:
6626:
6617:
6616:
6606:
6596:
6572:
6566:
6565:
6555:
6545:
6521:
6506:
6505:
6503:
6501:
6486:
6480:
6479:
6477:
6475:
6460:
6454:
6453:
6443:
6407:
6401:
6400:
6390:
6366:
6360:
6359:
6349:
6339:
6315:
6309:
6308:
6298:
6296:10.2223/JPED.669
6274:
6268:
6267:
6241:
6232:
6226:
6225:
6185:
6179:
6178:
6142:
6136:
6135:
6107:
6098:
6097:
6087:
6063:
6054:
6053:
6025:
6019:
6018:
5990:
5984:
5983:
5963:
5957:
5956:
5924:
5918:
5917:
5889:
5883:
5882:
5854:
5848:
5847:
5819:
5813:
5812:
5784:
5778:
5777:
5749:
5743:
5742:
5714:
5708:
5707:
5697:
5673:
5667:
5666:
5638:
5632:
5631:
5621:
5589:
5583:
5582:
5554:
5548:
5543:
5541:
5539:
5531:
5520:Retraction Watch
5499:
5489:
5465:
5459:
5458:
5448:
5424:
5415:
5414:
5378:
5372:
5371:
5361:
5329:
5323:
5322:
5312:
5288:
5279:
5278:
5242:
5236:
5235:
5225:
5201:
5186:
5185:
5149:
5143:
5142:
5105:
5099:
5098:
5066:
5060:
5059:
5039:
5033:
5032:
5022:
4998:
4992:
4991:
4963:
4957:
4956:
4928:
4922:
4921:
4893:
4882:
4881:
4871:
4847:
4838:
4837:
4827:
4803:
4790:
4789:
4761:
4752:
4751:
4715:
4709:
4708:
4688:
4682:
4681:
4671:
4647:
4641:
4640:
4612:
4606:
4605:
4600:. Archived from
4561:
4555:
4554:
4518:
4512:
4511:
4475:
4469:
4468:
4440:
4434:
4433:
4423:
4391:
4382:
4381:
4361:
4352:
4351:
4341:
4331:
4307:
4296:
4295:
4293:
4291:
4276:
4270:
4269:
4241:
4235:
4234:
4224:
4200:
4194:
4193:
4157:
4146:
4145:
4135:
4111:
4105:
4104:
4094:
4070:
4064:
4063:
4027:
4021:
4020:
4002:
3992:
3986:
3985:
3953:
3944:
3943:
3933:
3901:
3895:
3894:
3884:
3852:
3846:
3845:
3835:
3811:
3805:
3804:
3794:
3762:
3756:
3755:
3729:
3720:
3714:
3713:
3677:
3671:
3670:
3660:
3636:
3605:
3604:
3586:
3577:
3568:
3567:
3531:
3522:
3521:
3501:
3495:
3494:
3466:
3460:
3459:
3423:
3417:
3416:
3396:
3390:
3389:
3357:
3351:
3350:
3340:
3308:
3291:
3290:
3280:
3256:
3250:
3249:
3221:
3212:
3211:
3175:
3169:
3168:
3140:
3134:
3133:
3102:Acta Paediatrica
3097:
3091:
3090:
3072:
3066:
3065:
3055:
3053:10.1536/ihj.36.1
3031:
3022:
3021:
3011:
2979:
2940:
2939:
2919:
2910:
2909:
2899:
2867:
2861:
2860:
2858:
2856:
2841:
2832:
2831:
2821:
2811:
2787:
2781:
2780:
2770:
2738:
2732:
2731:
2721:
2711:
2687:
2678:
2677:
2643:
2634:
2623:
2622:
2617:. Archived from
2598:
2587:
2586:
2583:Kawasaki Disease
2578:
2572:
2571:
2561:
2539:
2529:
2505:
2470:
2469:
2445:
2434:
2433:
2423:
2391:
2360:
2359:
2357:
2347:
2336:
2335:
2317:
2311:
2310:
2308:
2306:
2287:
2181:lipid metabolism
2121:cyclophosphamide
2063:, and pediatric
1954:autoinflammatory
1852:infections; and
1611:, and childhood
1544:echocardiography
1477:
1472:
1471:
1260:mental confusion
1127:carotid arteries
1115:femoral arteries
1056:tricuspid valves
1001:white-blood-cell
895:echocardiography
881:, diarrhea, and
786:can also occur.
664:pleural effusion
474:
473:
427:mouth and throat
418:can occur, too.
408:Anterior uveitis
234:Kawasaki disease
194:and intravenous
121:< 5 years old
55:
38:Kawasaki disease
35:
34:
21:
10047:
10046:
10042:
10041:
10040:
10038:
10037:
10036:
9987:
9986:
9985:
9980:
9955:
9924:
9901:
9846:
9818:
9795:
9790:
9760:
9755:
9754:
9687:
9686:
9619:
9594:
9589:
9588:
9573:
9559:
9555:
9512:
9505:
9483:
9479:
9448:
9444:
9405:
9401:
9392:(in Japanese).
9386:
9382:
9372:
9370:
9369:. 17 March 2012
9366:The Japan Times
9359:
9358:
9354:
9325:
9321:
9308:
9307:
9303:
9290:
9289:
9285:
9254:
9250:
9240:
9238:
9225:
9224:
9220:
9207:
9206:
9202:
9160:
9154:
9150:
9143:
9127:
9123:
9084:
9080:
9049:
9045:
9037:
8998:
8992:
8988:
8956:
8952:
8913:
8909:
8878:
8874:
8843:
8839:
8816:
8812:
8781:
8777:
8738:(5): CD011188.
8724:
8720:
8683:
8679:
8648:
8644:
8604:
8600:
8567:(8): CD012448.
8553:
8549:
8494:
8490:
8480:
8478:
8465:
8464:
8460:
8427:(4): CD004175.
8413:
8409:
8372:
8368:
8358:
8356:
8347:
8346:
8342:
8305:
8301:
8270:(4): CD004000.
8256:
8249:
8239:
8237:
8224:
8223:
8216:
8177:
8173:
8146:Presse Médicale
8142:
8138:
8125:(36): 2784–87.
8111:
8107:
8070:
8066:
8035:
8031:
7986:
7982:
7972:
7970:
7965:
7964:
7960:
7937:
7924:
7887:
7883:
7836:
7832:
7784:
7780:
7735:
7731:
7721:
7719:
7710:
7709:
7702:
7692:
7690:
7682:
7681:
7674:
7658:
7657:
7629:(12): 731–748.
7615:
7611:
7588:(51): 6582–96.
7574:
7570:
7541:(10): 1578–83.
7531:
7527:
7517:
7515:
7506:
7505:
7501:
7470:
7466:
7456:
7454:
7444:
7443:
7439:
7416:(14): 1738–49.
7402:
7398:
7353:
7342:
7335:
7321:
7317:
7272:
7268:
7223:
7212:
7195:
7173:
7166:
7133:(8): 995–1009.
7119:
7112:
7057:
7053:
7037:10.1038/484021a
7022:(7392): 21–23.
7008:
7004:
6970:
6964:
6960:
6907:
6903:
6860:
6856:
6809:
6805:
6766:
6762:
6717:
6713:
6668:
6664:
6627:
6620:
6573:
6569:
6522:
6509:
6499:
6497:
6492:. Mayo Clinic.
6488:
6487:
6483:
6473:
6471:
6462:
6461:
6457:
6408:
6404:
6367:
6363:
6316:
6312:
6275:
6271:
6239:
6233:
6229:
6186:
6182:
6143:
6139:
6108:
6101:
6064:
6057:
6026:
6022:
5991:
5987:
5970:(in Japanese).
5964:
5960:
5925:
5921:
5890:
5886:
5855:
5851:
5820:
5816:
5785:
5781:
5750:
5746:
5715:
5711:
5674:
5670:
5639:
5635:
5590:
5586:
5555:
5551:
5533:
5525:
5523:
5500:
5480:(16): 2119–25.
5466:
5462:
5425:
5418:
5379:
5375:
5330:
5326:
5289:
5282:
5243:
5239:
5202:
5189:
5150:
5146:
5106:
5102:
5067:
5063:
5040:
5036:
4999:
4995:
4964:
4960:
4929:
4925:
4894:
4885:
4848:
4841:
4804:
4793:
4762:
4755:
4716:
4712:
4695:(in Japanese).
4689:
4685:
4648:
4644:
4613:
4609:
4562:
4558:
4519:
4515:
4476:
4472:
4441:
4437:
4392:
4385:
4368:(in Japanese).
4362:
4355:
4308:
4299:
4289:
4287:
4278:
4277:
4273:
4242:
4238:
4201:
4197:
4158:
4149:
4112:
4108:
4071:
4067:
4028:
4024:
4000:
3993:
3989:
3954:
3947:
3902:
3898:
3853:
3849:
3812:
3808:
3763:
3759:
3727:
3721:
3717:
3678:
3674:
3637:
3608:
3584:
3578:
3571:
3532:
3525:
3502:
3498:
3467:
3463:
3424:
3420:
3397:
3393:
3358:
3354:
3309:
3294:
3257:
3253:
3222:
3215:
3176:
3172:
3141:
3137:
3108:(10): 1057–60.
3098:
3094:
3087:
3073:
3069:
3032:
3025:
2980:
2943:
2920:
2913:
2868:
2864:
2854:
2852:
2843:
2842:
2835:
2788:
2784:
2739:
2735:
2688:
2681:
2641:
2635:
2626:
2599:
2590:
2579:
2575:
2540:
2506:
2473:
2462:
2446:
2437:
2392:
2363:
2355:
2349:
2348:
2339:
2332:
2318:
2314:
2304:
2302:
2289:
2288:
2243:
2238:
2222:
2192:
2161:bypass grafting
2134:
2125:plasma exchange
2116:Corticosteroids
2053:
1942:
1906:
1882:rheumatic fever
1814:
1806:case definition
1798:
1796:Case definition
1777:
1752:Lumbar puncture
1672:and eventually
1656:
1575:, with largest
1475:
1470:
1462:DNA methylation
1460:level, altered
1399:candidate genes
1390:
1372:Seasonal trends
1366:an unidentified
1323:
1145:, and abnormal
1103:axillary artery
1099:abdominal aorta
1091:
1005:high band count
956:
914:Coronary artery
906:lymphadenopathy
834:Other reported
532:intussusception
485:Manifestations
446:microvasculitis
352:
285:immune response
236:(also known as
33:
28:
23:
22:
15:
12:
11:
5:
10045:
10035:
10034:
10029:
10024:
10019:
10014:
10009:
10004:
9999:
9982:
9981:
9979:
9978:
9973:
9967:
9965:
9961:
9960:
9957:
9956:
9954:
9953:
9948:
9943:
9938:
9932:
9930:
9926:
9925:
9923:
9922:
9920:IgA vasculitis
9917:
9911:
9909:
9903:
9902:
9900:
9899:
9898:
9897:
9892:
9880:
9879:
9878:
9865:
9863:
9854:
9848:
9847:
9845:
9844:
9839:
9834:
9828:
9826:
9820:
9819:
9817:
9816:
9811:
9805:
9803:
9797:
9796:
9789:
9788:
9781:
9774:
9766:
9757:
9756:
9753:
9752:
9741:
9730:
9719:
9717:article/965367
9708:
9696:
9695:
9693:
9689:
9688:
9685:
9684:
9673:
9662:
9651:
9636:
9620:
9615:
9614:
9612:
9611:Classification
9605:
9604:
9593:
9592:External links
9590:
9587:
9586:
9571:
9553:
9503:
9477:
9458:(6): 599–607.
9442:
9399:
9390:Shonika Rinsho
9380:
9352:
9319:
9301:
9283:
9264:(3): 495–501.
9248:
9218:
9200:
9148:
9141:
9121:
9078:
9043:
8986:
8950:
8907:
8872:
8853:(13): 846–51.
8837:
8810:
8791:(9): 1116–20.
8775:
8718:
8677:
8642:
8598:
8547:
8488:
8458:
8407:
8386:(6): e689–93.
8366:
8340:
8299:
8247:
8214:
8171:
8136:
8105:
8064:
8029:
8000:(9): 1641–52.
7980:
7958:
7922:
7901:(3): 246–248.
7881:
7830:
7778:
7729:
7700:
7672:
7609:
7568:
7525:
7499:
7464:
7451:mayoclinic.org
7437:
7396:
7340:
7333:
7315:
7286:(11): 1850–7.
7266:
7243:10.14740/cr993
7210:
7193:
7164:
7110:
7071:(22): 7952–7.
7051:
7002:
6981:(10): 2284–9.
6958:
6901:
6854:
6803:
6760:
6711:
6662:
6629:Lo MS (2020).
6618:
6567:
6507:
6481:
6455:
6426:(5): 394–401.
6402:
6361:
6324:BMC Pediatrics
6310:
6269:
6227:
6180:
6137:
6099:
6055:
6020:
5985:
5958:
5919:
5884:
5849:
5814:
5779:
5744:
5709:
5668:
5633:
5584:
5549:
5460:
5416:
5389:(4): 398–402.
5373:
5324:
5280:
5237:
5216:(3): 295–300.
5187:
5144:
5100:
5061:
5034:
4993:
4958:
4923:
4883:
4839:
4818:(6): 1379–85.
4791:
4753:
4710:
4683:
4642:
4607:
4604:on 2 May 2020.
4576:(6): 1057–61.
4556:
4513:
4470:
4435:
4383:
4353:
4297:
4271:
4236:
4195:
4147:
4126:(5): 1776–80.
4106:
4085:(12): 1163–5.
4065:
4022:
4007:(in Spanish).
3987:
3964:(in Spanish).
3945:
3896:
3847:
3806:
3757:
3715:
3672:
3606:
3569:
3523:
3496:
3461:
3434:(3): 258–261.
3418:
3391:
3368:(in Spanish).
3352:
3292:
3271:(23): 1633–9.
3251:
3213:
3186:(9): 2953–54.
3170:
3135:
3092:
3085:
3067:
3023:
2941:
2930:(3): 178–222.
2911:
2862:
2833:
2782:
2753:(6): 793–802.
2733:
2702:(8): 413–414.
2679:
2624:
2621:on 6 May 2020.
2588:
2573:
2471:
2460:
2435:
2361:
2337:
2330:
2312:
2240:
2239:
2237:
2234:
2221:
2218:
2191:
2188:
2177:fluid overload
2133:
2130:
2052:
2049:
1986:histologically
1941:
1940:Classification
1938:
1905:
1902:
1874:parvovirus B19
1830:staphylococcal
1813:
1810:
1797:
1794:
1776:
1773:
1766:
1765:
1759:
1749:
1735:
1721:
1718:
1700:
1699:
1689:
1683:
1677:
1674:thrombocytosis
1655:
1654:Investigations
1652:
1647:
1646:
1643:
1640:
1637:
1634:
1593:history-taking
1557:
1556:
1552:
1551:
1539:
1538:
1534:
1533:
1526:
1525:
1517:
1516:
1504:
1503:
1492:
1491:
1489:conjunctivitis
1484:
1483:
1479:
1478:
1469:
1466:
1389:
1386:
1339:Classification
1322:
1319:
1199:optic neuritis
1123:distensibility
1090:
1087:
1038:abdominal pain
955:
952:
933:
932:
921:
910:thrombocytosis
898:
759:lesions; even
702:
701:
697:
696:
675:
671:
670:
653:
647:
646:
629:
623:
622:
593:
587:
586:
569:
563:
562:
553:
547:
546:
504:abdominal pain
493:
487:
486:
483:
479:
478:
351:
348:
328:immunoglobulin
287:to particular
229:
228:
223:
217:
216:
213:
209:
208:
205:
199:
198:
196:immunoglobulin
188:
182:
181:
168:
162:
161:
155:
149:
148:
145:
139:
138:
135:
131:
130:
127:
123:
122:
119:
115:
114:
109:
103:
102:
88:
82:
81:
68:
62:
61:
57:
56:
48:
47:
44:
40:
39:
31:
26:
9:
6:
4:
3:
2:
10044:
10033:
10030:
10028:
10025:
10023:
10020:
10018:
10015:
10013:
10010:
10008:
10007:Inflammations
10005:
10003:
10000:
9998:
9995:
9994:
9992:
9977:
9974:
9972:
9969:
9968:
9966:
9962:
9952:
9949:
9947:
9944:
9942:
9939:
9937:
9934:
9933:
9931:
9927:
9921:
9918:
9916:
9913:
9912:
9910:
9908:
9904:
9896:
9893:
9891:
9888:
9887:
9886:
9885:
9881:
9877:
9874:
9873:
9872:
9871:
9867:
9866:
9864:
9862:
9858:
9855:
9853:
9849:
9843:
9840:
9838:
9835:
9833:
9830:
9829:
9827:
9825:
9824:Medium vessel
9821:
9815:
9812:
9810:
9807:
9806:
9804:
9802:
9798:
9794:
9787:
9782:
9780:
9775:
9773:
9768:
9767:
9764:
9751:
9747:
9746:
9742:
9740:
9736:
9735:
9731:
9729:
9725:
9724:
9720:
9718:
9714:
9713:
9709:
9707:
9703:
9702:
9698:
9697:
9694:
9690:
9683:
9679:
9678:
9674:
9672:
9668:
9667:
9663:
9661:
9657:
9656:
9652:
9650:
9646:
9645:
9641:
9637:
9635:
9631:
9630:
9626:
9622:
9621:
9618:
9613:
9609:
9603:
9599:
9596:
9595:
9582:
9578:
9574:
9568:
9564:
9557:
9549:
9545:
9541:
9537:
9533:
9529:
9525:
9521:
9517:
9510:
9508:
9499:
9495:
9491:
9487:
9481:
9473:
9469:
9465:
9461:
9457:
9453:
9446:
9438:
9434:
9430:
9426:
9422:
9418:
9415:(3): 271–76.
9414:
9410:
9403:
9395:
9391:
9384:
9368:
9367:
9362:
9356:
9347:
9342:
9338:
9334:
9330:
9323:
9315:
9311:
9305:
9297:
9293:
9287:
9279:
9275:
9271:
9267:
9263:
9259:
9252:
9236:
9232:
9228:
9222:
9214:
9210:
9204:
9196:
9192:
9188:
9184:
9179:
9174:
9170:
9166:
9159:
9152:
9144:
9142:9780323296991
9138:
9134:
9133:
9125:
9117:
9113:
9109:
9105:
9101:
9097:
9094:(8): 693–94.
9093:
9089:
9082:
9074:
9070:
9066:
9062:
9059:(4): 695–99.
9058:
9054:
9047:
9036:
9032:
9028:
9024:
9020:
9016:
9012:
9009:(8): 437–47.
9008:
9004:
8997:
8990:
8982:
8978:
8974:
8970:
8967:(2): 181–86.
8966:
8962:
8954:
8946:
8942:
8938:
8934:
8930:
8926:
8923:(5): 558–62.
8922:
8918:
8911:
8903:
8899:
8895:
8891:
8888:(5): 705–10.
8887:
8883:
8876:
8868:
8864:
8860:
8856:
8852:
8848:
8841:
8833:
8829:
8825:
8821:
8814:
8806:
8802:
8798:
8794:
8790:
8786:
8779:
8771:
8767:
8762:
8757:
8753:
8749:
8745:
8741:
8737:
8733:
8729:
8722:
8714:
8710:
8705:
8700:
8697:(7): 663–75.
8696:
8692:
8688:
8681:
8673:
8669:
8665:
8661:
8658:(6): 611–16.
8657:
8653:
8646:
8638:
8634:
8630:
8626:
8622:
8618:
8614:
8610:
8602:
8594:
8590:
8585:
8580:
8575:
8570:
8566:
8562:
8558:
8551:
8543:
8539:
8534:
8529:
8524:
8519:
8515:
8511:
8507:
8503:
8499:
8492:
8476:
8472:
8468:
8462:
8454:
8450:
8445:
8440:
8435:
8430:
8426:
8422:
8418:
8411:
8403:
8399:
8394:
8389:
8385:
8381:
8377:
8370:
8354:
8353:www.pcori.org
8350:
8344:
8336:
8332:
8327:
8322:
8318:
8314:
8310:
8303:
8295:
8291:
8286:
8281:
8277:
8273:
8269:
8265:
8261:
8254:
8252:
8235:
8231:
8227:
8221:
8219:
8210:
8206:
8202:
8198:
8194:
8190:
8187:(5): 430–38.
8186:
8182:
8175:
8167:
8163:
8159:
8155:
8151:
8148:(in French).
8147:
8140:
8132:
8128:
8124:
8121:(in Danish).
8120:
8116:
8109:
8101:
8097:
8092:
8087:
8083:
8079:
8075:
8068:
8060:
8056:
8052:
8048:
8045:(6): 337–45.
8044:
8040:
8033:
8025:
8021:
8016:
8011:
8007:
8003:
7999:
7995:
7991:
7984:
7968:
7962:
7954:
7950:
7947:(5): 480–86.
7946:
7943:(in French).
7942:
7935:
7933:
7931:
7929:
7927:
7918:
7914:
7909:
7904:
7900:
7896:
7892:
7885:
7877:
7873:
7868:
7863:
7858:
7853:
7849:
7845:
7841:
7834:
7826:
7822:
7817:
7812:
7807:
7802:
7798:
7794:
7790:
7782:
7774:
7770:
7765:
7760:
7756:
7752:
7748:
7744:
7740:
7733:
7717:
7713:
7707:
7705:
7689:
7685:
7679:
7677:
7668:
7662:
7654:
7650:
7645:
7640:
7636:
7632:
7628:
7624:
7620:
7613:
7605:
7601:
7596:
7591:
7587:
7583:
7579:
7572:
7564:
7560:
7556:
7552:
7548:
7544:
7540:
7536:
7529:
7513:
7509:
7503:
7495:
7491:
7487:
7483:
7479:
7475:
7468:
7453:
7452:
7447:
7441:
7433:
7429:
7424:
7419:
7415:
7411:
7407:
7400:
7392:
7388:
7383:
7378:
7374:
7370:
7367:(7): 936–41.
7366:
7362:
7358:
7351:
7349:
7347:
7345:
7336:
7334:1-4160-0159-X
7330:
7326:
7319:
7311:
7307:
7302:
7297:
7293:
7289:
7285:
7281:
7277:
7270:
7262:
7258:
7253:
7248:
7244:
7240:
7236:
7232:
7228:
7221:
7219:
7217:
7215:
7205:
7200:
7196:
7194:9780323241458
7190:
7186:
7182:
7178:
7171:
7169:
7160:
7156:
7151:
7146:
7141:
7136:
7132:
7128:
7124:
7117:
7115:
7106:
7102:
7097:
7092:
7087:
7082:
7078:
7074:
7070:
7066:
7062:
7055:
7047:
7043:
7038:
7033:
7029:
7025:
7021:
7017:
7013:
7006:
6997:
6992:
6988:
6984:
6980:
6976:
6969:
6962:
6954:
6950:
6945:
6940:
6936:
6932:
6928:
6924:
6920:
6916:
6912:
6905:
6897:
6893:
6889:
6885:
6881:
6877:
6873:
6869:
6865:
6858:
6850:
6846:
6841:
6836:
6831:
6826:
6822:
6818:
6814:
6807:
6799:
6795:
6791:
6787:
6783:
6779:
6776:(3): 357–61.
6775:
6771:
6764:
6756:
6752:
6747:
6742:
6738:
6734:
6730:
6726:
6722:
6715:
6707:
6703:
6698:
6693:
6689:
6685:
6681:
6677:
6673:
6666:
6658:
6654:
6649:
6644:
6640:
6636:
6632:
6625:
6623:
6614:
6610:
6605:
6600:
6595:
6590:
6586:
6582:
6578:
6571:
6563:
6559:
6554:
6549:
6544:
6539:
6535:
6531:
6527:
6520:
6518:
6516:
6514:
6512:
6495:
6491:
6485:
6469:
6465:
6459:
6451:
6447:
6442:
6437:
6433:
6429:
6425:
6421:
6417:
6413:
6406:
6398:
6394:
6389:
6384:
6380:
6376:
6372:
6365:
6357:
6353:
6348:
6343:
6338:
6333:
6329:
6325:
6321:
6314:
6306:
6302:
6297:
6292:
6288:
6284:
6280:
6273:
6265:
6261:
6257:
6253:
6249:
6245:
6238:
6231:
6223:
6219:
6215:
6211:
6207:
6203:
6200:(3): e783–5.
6199:
6195:
6191:
6184:
6176:
6172:
6168:
6164:
6160:
6156:
6152:
6148:
6141:
6133:
6129:
6125:
6121:
6117:
6113:
6106:
6104:
6095:
6091:
6086:
6081:
6078:(7): 1320–1.
6077:
6073:
6069:
6062:
6060:
6051:
6047:
6043:
6039:
6035:
6031:
6024:
6016:
6012:
6008:
6004:
6000:
5996:
5989:
5981:
5977:
5974:(5): 429–35.
5973:
5969:
5962:
5954:
5950:
5946:
5942:
5939:(3): 239–41.
5938:
5934:
5930:
5923:
5915:
5911:
5907:
5903:
5899:
5895:
5888:
5880:
5876:
5872:
5868:
5865:(5): 303–04.
5864:
5860:
5853:
5845:
5841:
5837:
5833:
5829:
5825:
5818:
5810:
5806:
5802:
5798:
5794:
5790:
5783:
5775:
5771:
5767:
5763:
5759:
5755:
5748:
5740:
5736:
5732:
5728:
5724:
5720:
5713:
5705:
5701:
5696:
5691:
5688:(5): e504–6.
5687:
5683:
5679:
5672:
5664:
5660:
5656:
5652:
5649:(4): 648–50.
5648:
5644:
5637:
5629:
5625:
5620:
5615:
5611:
5607:
5603:
5599:
5595:
5588:
5580:
5576:
5572:
5568:
5564:
5560:
5553:
5546:
5537:
5529:
5522:
5521:
5516:
5512:
5508:
5504:
5497:
5493:
5488:
5483:
5479:
5475:
5471:
5464:
5456:
5452:
5447:
5442:
5438:
5434:
5430:
5423:
5421:
5412:
5408:
5404:
5400:
5396:
5392:
5388:
5384:
5377:
5369:
5365:
5360:
5355:
5351:
5347:
5343:
5339:
5335:
5328:
5320:
5316:
5311:
5306:
5303:(9): 2103–6.
5302:
5298:
5294:
5287:
5285:
5276:
5272:
5268:
5264:
5260:
5256:
5252:
5248:
5241:
5233:
5229:
5224:
5219:
5215:
5211:
5207:
5200:
5198:
5196:
5194:
5192:
5183:
5179:
5175:
5171:
5167:
5163:
5159:
5155:
5148:
5140:
5136:
5132:
5128:
5124:
5120:
5116:
5112:
5104:
5096:
5092:
5088:
5084:
5081:(7): 919–22.
5080:
5076:
5072:
5065:
5057:
5053:
5049:
5045:
5038:
5030:
5026:
5021:
5016:
5012:
5008:
5004:
4997:
4989:
4985:
4981:
4977:
4974:(2): 366–72.
4973:
4969:
4962:
4954:
4950:
4946:
4942:
4939:(4): 386–90.
4938:
4934:
4927:
4919:
4915:
4911:
4907:
4903:
4899:
4892:
4890:
4888:
4879:
4875:
4870:
4865:
4862:(2): 387–94.
4861:
4857:
4853:
4846:
4844:
4835:
4831:
4826:
4821:
4817:
4813:
4809:
4802:
4800:
4798:
4796:
4787:
4783:
4779:
4775:
4772:(3): 388–92.
4771:
4767:
4760:
4758:
4749:
4745:
4741:
4737:
4733:
4729:
4726:(6): 805–10.
4725:
4721:
4714:
4706:
4702:
4698:
4694:
4687:
4679:
4675:
4670:
4665:
4662:(2): 916–22.
4661:
4657:
4653:
4646:
4638:
4634:
4630:
4626:
4623:(6): 888–93.
4622:
4618:
4611:
4603:
4599:
4595:
4591:
4587:
4583:
4579:
4575:
4571:
4567:
4560:
4552:
4548:
4544:
4540:
4536:
4532:
4528:
4524:
4517:
4509:
4505:
4501:
4497:
4493:
4489:
4486:(8): 577–80.
4485:
4481:
4474:
4466:
4462:
4458:
4454:
4451:(5): 759–63.
4450:
4446:
4439:
4431:
4427:
4422:
4417:
4413:
4409:
4405:
4401:
4397:
4390:
4388:
4379:
4375:
4372:(1): 89–104.
4371:
4367:
4360:
4358:
4349:
4345:
4340:
4335:
4330:
4325:
4321:
4317:
4313:
4306:
4304:
4302:
4285:
4281:
4275:
4267:
4263:
4259:
4255:
4251:
4247:
4240:
4232:
4228:
4223:
4218:
4214:
4210:
4206:
4199:
4191:
4187:
4183:
4179:
4175:
4171:
4168:(6): 857–67.
4167:
4163:
4156:
4154:
4152:
4143:
4139:
4134:
4129:
4125:
4121:
4117:
4110:
4102:
4098:
4093:
4088:
4084:
4080:
4076:
4069:
4061:
4057:
4053:
4049:
4045:
4041:
4038:(12): 770–1.
4037:
4033:
4026:
4018:
4014:
4010:
4006:
3998:
3991:
3983:
3979:
3975:
3971:
3967:
3963:
3959:
3952:
3950:
3941:
3937:
3932:
3927:
3923:
3919:
3915:
3911:
3907:
3900:
3892:
3888:
3883:
3878:
3874:
3870:
3866:
3862:
3858:
3851:
3843:
3839:
3834:
3829:
3826:(4): 317–29.
3825:
3821:
3817:
3810:
3802:
3798:
3793:
3788:
3784:
3780:
3777:(11): 502–4.
3776:
3772:
3768:
3761:
3753:
3749:
3745:
3741:
3738:(10): 956–9.
3737:
3733:
3726:
3719:
3711:
3707:
3703:
3699:
3695:
3691:
3687:
3683:
3676:
3668:
3664:
3659:
3654:
3651:(4): 317–29.
3650:
3646:
3642:
3635:
3633:
3631:
3629:
3627:
3625:
3623:
3621:
3619:
3617:
3615:
3613:
3611:
3602:
3598:
3595:(8): E560–4.
3594:
3590:
3583:
3576:
3574:
3565:
3561:
3557:
3553:
3549:
3545:
3542:(6): 359–62.
3541:
3537:
3530:
3528:
3519:
3515:
3511:
3507:
3500:
3492:
3488:
3484:
3480:
3476:
3472:
3465:
3457:
3453:
3449:
3445:
3441:
3437:
3433:
3429:
3422:
3414:
3410:
3406:
3402:
3395:
3387:
3383:
3379:
3375:
3372:(4): 323–27.
3371:
3367:
3363:
3356:
3348:
3344:
3339:
3334:
3330:
3326:
3322:
3318:
3314:
3307:
3305:
3303:
3301:
3299:
3297:
3288:
3284:
3279:
3274:
3270:
3266:
3262:
3255:
3247:
3243:
3239:
3235:
3232:(2): 177–80.
3231:
3227:
3220:
3218:
3209:
3205:
3201:
3197:
3193:
3189:
3185:
3181:
3174:
3166:
3162:
3158:
3154:
3151:(3): 409–13.
3150:
3146:
3139:
3131:
3127:
3123:
3119:
3115:
3111:
3107:
3103:
3096:
3088:
3082:
3078:
3071:
3063:
3059:
3054:
3049:
3045:
3041:
3037:
3030:
3028:
3019:
3015:
3010:
3005:
3001:
2997:
2994:(3): 405–14.
2993:
2989:
2985:
2978:
2976:
2974:
2972:
2970:
2968:
2966:
2964:
2962:
2960:
2958:
2956:
2954:
2952:
2950:
2948:
2946:
2937:
2933:
2929:
2925:
2918:
2916:
2907:
2903:
2898:
2893:
2889:
2885:
2882:(6): 411–20.
2881:
2877:
2873:
2866:
2850:
2846:
2840:
2838:
2829:
2825:
2820:
2815:
2810:
2805:
2801:
2797:
2793:
2786:
2778:
2774:
2769:
2764:
2760:
2756:
2752:
2748:
2747:Can J Cardiol
2744:
2737:
2729:
2725:
2720:
2715:
2710:
2705:
2701:
2697:
2693:
2686:
2684:
2675:
2671:
2667:
2663:
2659:
2655:
2652:(4): 672–82.
2651:
2647:
2640:
2633:
2631:
2629:
2620:
2616:
2612:
2608:
2604:
2597:
2595:
2593:
2584:
2577:
2569:
2565:
2560:
2555:
2551:
2547:
2543:
2537:
2533:
2528:
2523:
2519:
2515:
2511:
2504:
2502:
2500:
2498:
2496:
2494:
2492:
2490:
2488:
2486:
2484:
2482:
2480:
2478:
2476:
2467:
2463:
2461:9781118742488
2457:
2453:
2452:
2444:
2442:
2440:
2431:
2427:
2422:
2417:
2413:
2409:
2406:(6): 759–72.
2405:
2401:
2397:
2390:
2388:
2386:
2384:
2382:
2380:
2378:
2376:
2374:
2372:
2370:
2368:
2366:
2354:
2353:
2346:
2344:
2342:
2333:
2327:
2323:
2316:
2300:
2296:
2295:PubMed Health
2292:
2286:
2284:
2282:
2280:
2278:
2276:
2274:
2272:
2270:
2268:
2266:
2264:
2262:
2260:
2258:
2256:
2254:
2252:
2250:
2248:
2246:
2241:
2233:
2230:
2226:
2217:
2214:
2211:
2207:
2203:
2199:
2197:
2187:
2184:
2182:
2178:
2173:
2168:
2166:
2162:
2158:
2154:
2149:
2143:
2140:
2129:
2126:
2122:
2117:
2113:
2110:
2106:
2101:
2098:
2096:
2092:
2088:
2087:Reye syndrome
2083:
2079:
2076:
2072:
2068:
2066:
2062:
2058:
2048:
2046:
2042:
2038:
2034:
2029:
2026:
2020:
2018:
2014:
2010:
2006:
2001:
1999:
1998:vascular wall
1995:
1991:
1987:
1983:
1979:
1978:immune system
1975:
1970:
1967:
1966:immunological
1963:
1959:
1955:
1951:
1947:
1937:
1933:
1931:
1927:
1923:
1919:
1915:
1911:
1901:
1899:
1895:
1891:
1887:
1883:
1879:
1878:mononucleosis
1875:
1871:
1867:
1863:
1859:
1855:
1854:leptospirosis
1851:
1847:
1843:
1839:
1835:
1834:streptococcal
1831:
1827:
1823:
1819:
1809:
1807:
1803:
1793:
1790:
1787:
1783:
1772:
1770:
1763:
1760:
1757:
1753:
1750:
1747:
1743:
1739:
1736:
1733:
1729:
1725:
1722:
1719:
1716:
1712:
1708:
1705:
1704:
1703:
1697:
1693:
1690:
1687:
1684:
1681:
1678:
1675:
1671:
1667:
1664:
1663:
1662:
1659:
1651:
1644:
1641:
1638:
1635:
1632:
1629:
1628:
1627:
1625:
1620:
1618:
1614:
1610:
1606:
1602:
1601:scarlet fever
1598:
1595:and thorough
1594:
1590:
1586:
1578:
1574:
1571:
1567:
1563:
1554:
1553:
1549:
1545:
1541:
1540:
1536:
1535:
1531:
1528:
1527:
1523:
1520:Polymorphous
1519:
1518:
1514:
1510:
1506:
1505:
1502:
1498:
1494:
1493:
1490:
1486:
1485:
1481:
1480:
1474:
1473:
1465:
1463:
1459:
1455:
1451:
1447:
1446:polymorphisms
1443:
1442:
1437:
1436:
1431:
1430:
1425:
1424:
1419:
1418:
1413:
1412:
1406:
1404:
1400:
1396:
1385:
1382:
1377:
1373:
1369:
1367:
1363:
1359:
1355:
1351:
1347:
1342:
1340:
1336:
1332:
1328:
1318:
1316:
1312:
1308:
1304:
1303:night terrors
1300:
1296:
1295:hypoperfusion
1293:
1289:
1285:
1281:
1277:
1273:
1272:cranial nerve
1269:
1265:
1261:
1257:
1253:
1249:
1245:
1242:
1238:
1234:
1230:
1229:hypoperfusion
1227:
1223:
1219:
1214:
1212:
1208:
1204:
1200:
1196:
1193:
1189:
1188:iridocyclitis
1185:
1181:
1177:
1175:
1174:acute abdomen
1171:
1167:
1163:
1159:
1155:
1150:
1148:
1144:
1140:
1136:
1132:
1128:
1124:
1120:
1116:
1112:
1108:
1104:
1100:
1096:
1086:
1084:
1080:
1077:
1073:
1069:
1065:
1061:
1057:
1053:
1049:
1045:
1043:
1039:
1035:
1031:
1027:
1021:
1019:
1015:
1010:
1006:
1002:
998:
994:
989:
987:
983:
978:
973:
970:
960:
951:
949:
944:
942:
938:
930:
926:
922:
919:
915:
911:
907:
903:
899:
896:
892:
888:
884:
880:
876:
872:
868:
867:
866:
863:
861:
857:
853:
849:
845:
841:
837:
828:
824:
822:
817:
813:
812:lymphadenitis
809:
805:
801:
797:
793:
789:
785:
781:
776:
774:
770:
766:
762:
761:micropustules
758:
754:
750:
745:
741:
736:
734:
729:
725:
721:
717:
713:
709:
698:
695:
692:, and finger
691:
687:
683:
679:
676:
673:
672:
669:
665:
661:
657:
654:
652:
649:
648:
645:
641:
637:
633:
630:
628:
625:
624:
621:
617:
613:
609:
605:
601:
597:
594:
592:
589:
588:
585:
581:
577:
573:
570:
568:
565:
564:
561:
557:
556:Polyarthritis
554:
552:
549:
548:
545:
541:
537:
533:
529:
525:
521:
517:
513:
509:
505:
501:
497:
494:
492:
489:
488:
484:
481:
480:
475:
472:
470:
466:
462:
457:
453:
451:
447:
444:
440:
436:
432:
428:
423:
421:
417:
413:
409:
404:
399:
397:
393:
389:
385:
379:
377:
373:
369:
365:
356:
347:
345:
342:
336:
333:
329:
325:
320:
318:
314:
310:
306:
305:scarlet fever
302:
298:
294:
290:
286:
281:
279:
275:
271:
267:
263:
259:
255:
251:
247:
243:
239:
235:
227:
224:
222:
218:
214:
210:
206:
204:
200:
197:
193:
189:
187:
183:
180:
176:
172:
171:Scarlet fever
169:
167:
163:
160:
156:
154:
150:
146:
144:
140:
136:
132:
128:
124:
120:
116:
113:
110:
108:
107:Complications
104:
101:
97:
93:
89:
87:
83:
80:
76:
72:
69:
67:
63:
58:
54:
49:
45:
41:
36:
30:
19:
9882:
9868:
9861:Pauci-immune
9852:Small vessel
9836:
9801:Large vessel
9743:
9732:
9721:
9710:
9699:
9675:
9664:
9653:
9638:
9623:
9562:
9556:
9526:(1): 13–15.
9523:
9519:
9497:
9493:
9480:
9455:
9451:
9445:
9412:
9408:
9402:
9393:
9389:
9383:
9371:. Retrieved
9364:
9355:
9336:
9333:Rheumatology
9332:
9322:
9304:
9286:
9261:
9257:
9251:
9239:. Retrieved
9230:
9221:
9212:
9203:
9171:(1): 26–30.
9168:
9164:
9151:
9131:
9124:
9091:
9087:
9081:
9056:
9052:
9046:
9035:the original
9006:
9002:
8989:
8964:
8960:
8953:
8920:
8916:
8910:
8885:
8881:
8875:
8850:
8846:
8840:
8823:
8819:
8813:
8788:
8784:
8778:
8735:
8731:
8721:
8694:
8690:
8680:
8655:
8651:
8645:
8612:
8608:
8601:
8564:
8560:
8550:
8505:
8501:
8491:
8479:. Retrieved
8475:the original
8470:
8461:
8424:
8420:
8410:
8383:
8379:
8369:
8357:. Retrieved
8355:. 9 May 2024
8352:
8343:
8316:
8312:
8302:
8267:
8263:
8238:. Retrieved
8234:the original
8184:
8180:
8174:
8149:
8145:
8139:
8122:
8118:
8108:
8084:(1): 55–67.
8081:
8077:
8067:
8042:
8038:
8032:
7997:
7993:
7983:
7971:. Retrieved
7961:
7944:
7940:
7898:
7894:
7884:
7847:
7843:
7833:
7796:
7792:
7781:
7749:(1): 43–47.
7746:
7742:
7732:
7720:. Retrieved
7715:
7691:. Retrieved
7687:
7661:cite journal
7626:
7622:
7612:
7585:
7581:
7571:
7538:
7534:
7528:
7516:. Retrieved
7502:
7481:
7477:
7467:
7455:. Retrieved
7449:
7440:
7413:
7409:
7399:
7364:
7360:
7324:
7318:
7283:
7279:
7269:
7234:
7230:
7176:
7130:
7126:
7068:
7064:
7054:
7019:
7015:
7005:
6978:
6974:
6961:
6918:
6914:
6904:
6871:
6867:
6857:
6823:(8): 453–4.
6820:
6816:
6806:
6773:
6769:
6763:
6731:(1): 20–25.
6728:
6724:
6714:
6682:(6): 273–9.
6679:
6675:
6665:
6638:
6634:
6584:
6580:
6570:
6533:
6529:
6498:. Retrieved
6484:
6472:. Retrieved
6458:
6423:
6419:
6405:
6381:(5): 463–8.
6378:
6374:
6364:
6327:
6323:
6313:
6289:(1): 71–74.
6286:
6282:
6272:
6250:(5): 343–8.
6247:
6243:
6230:
6197:
6193:
6183:
6153:(1): 30–33.
6150:
6146:
6140:
6118:(3): 235–6.
6115:
6111:
6075:
6071:
6036:(2): 79–81.
6033:
6029:
6023:
6001:(3): 216–7.
5998:
5994:
5988:
5971:
5967:
5961:
5936:
5932:
5922:
5900:(1): 121–6.
5897:
5893:
5887:
5862:
5858:
5852:
5830:(3): 177–9.
5827:
5823:
5817:
5792:
5788:
5782:
5760:(6): 713–7.
5757:
5753:
5747:
5725:(6): 731–5.
5722:
5718:
5712:
5685:
5681:
5671:
5646:
5642:
5636:
5604:(4): 723–6.
5601:
5597:
5587:
5562:
5558:
5552:
5534:{{
5526:{{
5519:
5517:,
5477:
5473:
5463:
5439:(1): 120–4.
5436:
5432:
5386:
5382:
5376:
5344:(1): 43–47.
5341:
5337:
5327:
5300:
5296:
5253:(2): 197–9.
5250:
5246:
5240:
5213:
5209:
5160:(4): 521–5.
5157:
5153:
5147:
5117:(3): 252–5.
5114:
5110:
5103:
5078:
5074:
5064:
5050:(2): 231–4.
5047:
5043:
5037:
5013:(4): 894–7.
5010:
5006:
4996:
4971:
4967:
4961:
4936:
4932:
4926:
4904:(6): 923–7.
4901:
4897:
4859:
4855:
4815:
4811:
4769:
4765:
4723:
4719:
4713:
4699:(2): 332–7.
4696:
4692:
4686:
4659:
4655:
4645:
4620:
4616:
4610:
4602:the original
4573:
4569:
4559:
4526:
4522:
4516:
4483:
4479:
4473:
4448:
4444:
4438:
4406:(5): 681–4.
4403:
4399:
4369:
4365:
4319:
4315:
4288:. Retrieved
4274:
4252:(4): 450–5.
4249:
4245:
4239:
4212:
4208:
4198:
4165:
4161:
4123:
4119:
4109:
4082:
4078:
4068:
4035:
4031:
4025:
4011:(1): 39–43.
4008:
4004:
3990:
3968:(6): 610–1.
3965:
3961:
3916:(4): 353–5.
3913:
3909:
3899:
3867:(6): 538–9.
3864:
3860:
3850:
3823:
3819:
3809:
3774:
3770:
3760:
3735:
3731:
3718:
3688:(3): 525–8.
3685:
3681:
3675:
3648:
3644:
3592:
3588:
3539:
3535:
3512:(2): 116–8.
3509:
3505:
3499:
3477:(1): 101–2.
3474:
3470:
3464:
3431:
3427:
3421:
3407:(3): 162–4.
3404:
3403:(in Czech).
3400:
3394:
3369:
3365:
3355:
3323:(7): 394–8.
3320:
3316:
3268:
3264:
3254:
3229:
3225:
3183:
3179:
3173:
3148:
3144:
3138:
3105:
3101:
3095:
3076:
3070:
3043:
3039:
2991:
2987:
2927:
2923:
2879:
2875:
2865:
2853:. Retrieved
2802:: 45–54.e1.
2799:
2795:
2785:
2750:
2746:
2736:
2699:
2695:
2649:
2645:
2619:the original
2606:
2582:
2576:
2549:
2545:
2542:"Correction"
2517:
2513:
2450:
2403:
2399:
2351:
2321:
2315:
2303:. Retrieved
2294:
2231:
2227:
2223:
2215:
2212:
2208:
2204:
2200:
2193:
2190:Epidemiology
2185:
2169:
2144:
2138:
2135:
2114:
2102:
2099:
2080:
2069:
2061:rheumatology
2059:, pediatric
2054:
2030:
2021:
2002:
1971:
1960:rather than
1943:
1934:
1907:
1898:Lyme disease
1815:
1799:
1791:
1778:
1767:
1701:
1661:Blood tests
1660:
1657:
1648:
1621:
1582:
1513:skin peeling
1439:
1433:
1427:
1421:
1415:
1409:
1407:
1391:
1376:tropospheric
1370:
1362:superantigen
1343:
1324:
1280:facial palsy
1215:
1192:conjunctival
1178:
1151:
1119:renal artery
1092:
1046:
1022:
990:
974:
965:
945:
934:
925:convalescent
918:sudden death
864:
833:
796:pericarditis
777:
749:urticariform
737:
733:Beau's lines
720:desquamation
705:
690:Beau's lines
576:pericarditis
516:pancreatitis
454:
424:
400:
380:
376:irritability
361:
341:pediatrician
337:
321:
282:
264:area, lips,
237:
233:
232:
143:Risk factors
75:Rheumatology
29:
9701:MedlinePlus
7688:www.who.int
7237:(1): 9–14.
6410:Rowley AH,
5795:(5): 7–11.
5565:(9): e1–4.
5474:Circulation
5297:Circulation
4856:Circulation
4812:Circulation
4656:Circulation
4120:Circulation
3046:(1): 1–12.
2546:Circulation
2514:Circulation
2163:, and even
1850:rickettsial
1826:enterovirus
1762:Angiography
1746:proteinuria
1732:gallbladder
1711:ventricular
1668:may reveal
1605:toxic shock
1566:Angiography
1346:recurrences
1331:immunologic
1156:, such as:
1147:serum lipid
920:is highest.
808:pneumonitis
788:Myocarditis
668:atelectasis
600:prostatitis
580:tachycardia
572:Myocarditis
528:cholangitis
443:necrotizing
388:antibiotics
364:paracetamol
278:myocarditis
221:Named after
118:Usual onset
96:sore throat
43:Other names
10012:Pediatrics
9991:Categories
9723:Patient UK
9677:DiseasesDB
9572:0444822003
9409:Pediatrics
9258:Pediatrics
9053:Pediatrics
8826:: 519–20.
8609:The Lancet
8380:Pediatrics
8313:Pediatrics
7844:The Lancet
6641:: 108385.
6194:Pediatrics
5682:Pediatrics
4570:Pediatrics
4529:(1): 3–9.
4322:(1): 102.
4290:1 December
3682:Pediatrics
3086:0721652441
2607:StatPearls
2236:References
2082:Salicylate
2075:infliximab
2057:cardiology
1974:vasculitis
1950:autoimmune
1914:SARS-CoV-2
1886:meningitis
1822:adenovirus
1738:Urinalysis
1724:Ultrasound
1715:arrhythmia
1624:diagnostic
1607:syndrome,
1458:epigenetic
1311:depressive
1256:hemiplegia
1244:infarction
1241:cerebellar
1195:hemorrhage
1164:swelling,
1105:aneurysm,
1042:chest pain
993:hemoglobin
941:arthralgia
844:rhinorrhea
800:valvulitis
780:arthralgia
682:induration
596:Urethritis
560:arthralgia
500:chest pain
461:lymph node
401:Bilateral
289:infections
250:vasculitis
186:Medication
79:Immunology
71:Pediatrics
9929:Ungrouped
9712:eMedicine
9581:0531-5131
9396:: 291–97.
9241:18 August
9116:186231502
8752:1469-493X
8240:4 January
7457:5 October
6896:211034768
6500:3 January
6474:3 January
6330:(1): 14.
6222:207161115
5545:Retracted
5536:retracted
5528:retracted
2855:26 August
2305:26 August
2132:Prognosis
2095:influenza
2091:varicella
2051:Treatment
2023:100
1848:or other
1468:Diagnosis
1358:RNA virus
1327:infection
1203:amaurosis
1149:profile.
1014:Narrowing
937:hepatitis
891:aneurysms
816:hepatitis
784:arthritis
773:vesicular
765:not itchy
524:parotitis
372:remittent
368:ibuprofen
212:Frequency
203:Prognosis
129:~ 3 weeks
66:Specialty
9745:Orphanet
9548:34446653
9540:29152909
9488:(1871).
9437:13221240
9373:28 April
9314:Archived
9296:Archived
9278:12949272
9235:Archived
9195:37677965
9187:29152908
9108:29238944
9031:29371025
9023:12544719
8981:10931409
8945:39330448
8937:11737728
8770:35622534
8713:17301297
8672:12838187
8637:72335365
8629:30853151
8593:31425625
8542:26658843
8502:PLOS ONE
8453:17054199
8402:15545617
8335:37092277
8294:14584002
8209:25260955
8201:11123094
8166:17408915
8131:18761873
8100:19377760
8059:15223179
8051:17274537
8024:19946711
7953:18524103
7917:32511667
7876:32659211
7825:33031361
7773:35031265
7653:34716418
7604:27863715
7563:13412642
7555:20491705
7512:Archived
7494:Archived
7490:10392592
7432:27056781
7391:16322081
7310:27506874
7261:32095191
7159:28656474
7105:24843117
7046:22481336
6953:22355668
6888:32020498
6874:(2): 6.
6849:32546853
6798:24155085
6790:11964855
6755:29105346
6706:19075496
6657:32173601
6613:30619784
6562:30619331
6536:: 2974.
6494:Archived
6468:Archived
6450:18364728
6412:Baker SC
6397:10807296
6356:15916701
6305:14647816
6264:11562886
6214:18678602
6175:19461613
6167:15967620
6050:11589317
5953:11587880
5879:17913174
5844:15206604
5739:12838207
5704:15121996
5663:11283899
5628:18756065
5579:16150324
5515:22689940
5496:15851619
5455:14715193
5411:21586626
5403:15310302
5368:16820386
5275:11627024
5267:18704549
5232:21691693
5182:30747089
5139:30968335
5095:11274955
4748:56991692
4705:18260333
4598:22210926
4551:20301847
4430:17443379
4348:30157897
4284:Archived
4266:12006960
4231:20359606
4190:12989507
4101:18043462
4060:22194695
4052:16010565
4017:10083641
3982:18053534
3940:10999876
3891:19483521
3842:19851663
3801:19997548
3710:32616639
3667:19851663
3601:18059239
3564:32280647
3556:18476929
3491:10653425
3456:40875550
3413:18401983
3386:14519302
3347:21860641
3246:10931408
3200:21881982
3130:40359434
2906:31843876
2849:Archived
2847:. 2014.
2828:32768466
2777:36626979
2728:32499548
2674:54477877
2666:30535127
2615:30725848
2568:31356128
2536:28356445
2466:Archived
2430:17191303
2299:Archived
2151:such as
2148:fusiform
1994:fibrosis
1992:death),
1982:pathogen
1962:adaptive
1948:, as an
1946:pathogen
1918:COVID-19
1775:Subtypes
1631:erythema
1589:symptoms
1577:aneurysm
1568:showing
1509:swelling
1408:SNPs in
1388:Genetics
1350:pathogen
1292:cerebral
1264:lethargy
1248:seizures
1226:cerebral
1076:fibrosed
1034:vomiting
902:subacute
856:headache
852:vomiting
838:include
792:diarrhea
757:purpuric
694:gangrene
678:Erythema
636:semicoma
632:Lethargy
616:orchitis
608:priapism
604:cystitis
508:vomiting
496:Diarrhea
465:adenitis
317:COVID-19
270:red eyes
242:syndrome
126:Duration
100:diarrhea
94:, rash,
86:Symptoms
9671:D009080
9429:4153258
9073:9310527
8902:3668739
8867:4061324
8832:3423060
8805:9605052
8761:9139689
8584:6953355
8533:4686074
8510:Bibcode
8444:8765111
8359:30 June
8285:6544780
8015:2908435
7867:7351414
7816:7561225
7764:8739010
7644:8554518
7582:Vaccine
7382:1798210
7301:7185772
7252:7011927
7204:7161397
7150:5511310
7096:4050536
7073:Bibcode
7024:Bibcode
6983:Bibcode
6944:3240972
6923:Bibcode
6921:: 152.
6840:7296515
6746:5777874
6697:4771612
6604:6298241
6587:: 374.
6553:6302019
6441:7097362
6347:1156909
6132:1622525
6094:9660380
6015:3344468
5980:2223179
5914:1571415
5809:7299613
5774:7201245
5619:2526417
5359:2083125
5319:8901658
5174:7572158
5131:8741316
5056:8665019
5029:3958349
4988:2382613
4953:3341217
4918:3712157
4878:3802442
4834:8822996
4786:3950818
4740:1801561
4678:8313588
4637:9427895
4590:7491221
4543:3774580
4508:6125622
4500:1505575
4465:3772656
4421:1852903
4378:7264399
4339:6116535
4182:3766134
4142:8491037
3931:1718513
3882:2738931
3792:2790127
3752:3316594
3702:8115224
3518:2468129
3448:4039819
3338:3152734
3287:1709446
3208:1471650
3165:3819942
3122:7841704
3062:7760506
3018:9665974
2936:6062087
2924:Arerugi
2897:7057818
2819:7403869
2768:9824951
2719:7271827
2421:2687814
2220:History
2172:relapse
1818:measles
1802:vaccine
1570:ectatic
1448:in the
1307:anxious
1237:infarct
1184:uveitis
1143:obesity
1007:, high
1003:count,
997:albumin
986:rupture
954:Cardiac
948:infants
860:seizure
769:bullous
744:papular
740:macular
540:ascites
482:System
396:aspirin
324:aspirin
262:genital
240:) is a
192:Aspirin
137:Unknown
9884:p-ANCA
9870:c-ANCA
9706:000989
9660:611775
9602:Curlie
9579:
9569:
9546:
9538:
9486:Gee SJ
9470:
9435:
9427:
9276:
9193:
9185:
9139:
9114:
9106:
9071:
9029:
9021:
8979:
8943:
8935:
8900:
8865:
8830:
8803:
8768:
8758:
8750:
8711:
8670:
8635:
8627:
8591:
8581:
8540:
8530:
8451:
8441:
8400:
8333:
8292:
8282:
8207:
8199:
8164:
8129:
8098:
8057:
8049:
8022:
8012:
7973:19 May
7951:
7915:
7874:
7864:
7823:
7813:
7771:
7761:
7722:15 May
7693:16 May
7651:
7641:
7602:
7561:
7553:
7518:30 May
7488:
7430:
7389:
7379:
7331:
7308:
7298:
7259:
7249:
7201:
7191:
7157:
7147:
7103:
7093:
7044:
7016:Nature
6951:
6941:
6894:
6886:
6847:
6837:
6796:
6788:
6753:
6743:
6704:
6694:
6655:
6611:
6601:
6560:
6550:
6448:
6438:
6395:
6354:
6344:
6303:
6262:
6220:
6212:
6173:
6165:
6130:
6092:
6072:Stroke
6048:
6013:
5978:
5951:
5912:
5877:
5842:
5807:
5772:
5737:
5702:
5661:
5626:
5616:
5577:
5513:
5509:,
5494:
5453:
5409:
5401:
5366:
5356:
5317:
5273:
5265:
5230:
5180:
5172:
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5027:
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4832:
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4676:
4635:
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4541:
4506:
4498:
4463:
4428:
4418:
4376:
4346:
4336:
4264:
4229:
4188:
4180:
4140:
4099:
4058:
4050:
4015:
3980:
3938:
3928:
3889:
3879:
3840:
3799:
3789:
3750:
3708:
3700:
3665:
3599:
3562:
3554:
3516:
3489:
3454:
3446:
3411:
3384:
3345:
3335:
3285:
3244:
3206:
3198:
3163:
3128:
3120:
3083:
3060:
3016:
3006:
2934:
2904:
2894:
2826:
2816:
2775:
2765:
2726:
2716:
2672:
2664:
2613:
2566:
2534:
2458:
2428:
2418:
2328:
2043:, and
2015:, and
1990:tissue
1958:innate
1896:, and
1769:Biopsy
1742:pyuria
1411:FCGR2A
1321:Causes
1282:, and
1276:ataxia
1252:chorea
1205:, and
1172:, and
1133:, and
1117:, and
1095:aortic
1079:valves
1068:aortic
1052:mitral
1036:, and
1030:unrest
939:, and
858:, and
848:sputum
814:, and
755:, and
642:, and
431:tongue
416:Iritis
134:Causes
9964:Other
9649:446.1
9634:M30.3
9544:S2CID
9433:S2CID
9191:S2CID
9161:(pdf)
9112:S2CID
9038:(PDF)
9027:S2CID
8999:(PDF)
8941:S2CID
8633:S2CID
8481:8 May
8205:S2CID
8055:S2CID
7559:S2CID
6971:(PDF)
6892:S2CID
6794:S2CID
6240:(PDF)
6218:S2CID
6171:S2CID
5532:with
5407:S2CID
5271:S2CID
5178:S2CID
5135:S2CID
4744:S2CID
4594:S2CID
4547:S2CID
4504:S2CID
4186:S2CID
4056:S2CID
4001:(PDF)
3728:(PDF)
3706:S2CID
3585:(PDF)
3560:S2CID
3452:S2CID
3204:S2CID
3126:S2CID
3009:88887
2876:Heart
2670:S2CID
2642:(PDF)
2356:(PDF)
1980:to a
1585:signs
1441:ORAI1
1429:ITPKC
1417:CASP3
1162:colon
1131:aorta
1111:iliac
1089:Other
1026:shock
871:acute
840:cough
716:soles
712:palms
674:Skin
448:with
266:palms
246:fever
190:Oral
9750:2331
9734:NORD
9682:7121
9666:MeSH
9655:OMIM
9644:9-CM
9577:ISSN
9567:ISBN
9536:PMID
9472:7134
9468:PMID
9425:PMID
9375:2020
9274:PMID
9243:2014
9183:PMID
9137:ISBN
9104:PMID
9069:PMID
9019:PMID
8977:PMID
8933:PMID
8898:PMID
8863:PMID
8828:PMID
8801:PMID
8766:PMID
8748:ISSN
8736:2022
8709:PMID
8668:PMID
8625:PMID
8589:PMID
8565:2019
8538:PMID
8483:2020
8449:PMID
8425:2010
8398:PMID
8361:2024
8331:PMID
8290:PMID
8268:2021
8242:2009
8197:PMID
8162:PMID
8127:PMID
8096:PMID
8047:PMID
8020:PMID
7975:2010
7949:PMID
7913:PMID
7895:JAMA
7872:PMID
7821:PMID
7769:PMID
7724:2020
7695:2020
7667:link
7649:PMID
7600:PMID
7551:PMID
7520:2016
7486:PMID
7459:2018
7428:PMID
7387:PMID
7329:ISBN
7306:PMID
7257:PMID
7189:ISBN
7155:PMID
7101:PMID
7042:PMID
6949:PMID
6884:PMID
6845:PMID
6786:PMID
6751:PMID
6702:PMID
6653:PMID
6609:PMID
6558:PMID
6502:2009
6476:2009
6446:PMID
6393:PMID
6352:PMID
6301:PMID
6260:PMID
6210:PMID
6163:PMID
6128:PMID
6090:PMID
6046:PMID
6011:PMID
5976:PMID
5949:PMID
5910:PMID
5875:PMID
5840:PMID
5805:PMID
5770:PMID
5735:PMID
5700:PMID
5659:PMID
5624:PMID
5575:PMID
5511:PMID
5492:PMID
5451:PMID
5399:PMID
5364:PMID
5315:PMID
5263:PMID
5228:PMID
5170:PMID
5127:PMID
5091:PMID
5052:PMID
5025:PMID
4984:PMID
4949:PMID
4914:PMID
4874:PMID
4830:PMID
4782:PMID
4736:PMID
4701:PMID
4674:PMID
4633:PMID
4586:PMID
4539:PMID
4496:PMID
4461:PMID
4426:PMID
4374:PMID
4344:PMID
4292:2011
4262:PMID
4227:PMID
4178:PMID
4138:PMID
4097:PMID
4048:PMID
4013:PMID
3978:PMID
3936:PMID
3887:PMID
3838:PMID
3797:PMID
3748:PMID
3698:PMID
3663:PMID
3597:PMID
3552:PMID
3514:PMID
3487:PMID
3444:PMID
3409:PMID
3382:PMID
3343:PMID
3283:PMID
3242:PMID
3196:PMID
3161:PMID
3118:PMID
3081:ISBN
3058:PMID
3014:PMID
2932:PMID
2902:PMID
2857:2016
2824:PMID
2773:PMID
2724:PMID
2662:PMID
2611:PMID
2564:PMID
2532:PMID
2456:ISBN
2426:PMID
2326:ISBN
2307:2016
2139:i.e.
2123:and
2093:and
1832:and
1744:and
1587:and
1522:rash
1438:and
1435:CD40
1268:coma
1266:and
1235:and
1113:and
977:IVIG
923:The
900:The
869:The
724:toes
714:and
680:and
558:and
394:and
326:and
307:and
276:and
9640:ICD
9625:ICD
9600:at
9528:doi
9460:doi
9456:130
9417:doi
9341:doi
9266:doi
9262:112
9231:CDC
9173:doi
9096:doi
9061:doi
9057:100
9011:doi
8969:doi
8965:137
8925:doi
8890:doi
8886:111
8855:doi
8824:250
8793:doi
8756:PMC
8740:doi
8699:doi
8695:356
8660:doi
8656:142
8617:doi
8613:393
8579:PMC
8569:doi
8528:PMC
8518:doi
8439:PMC
8429:doi
8388:doi
8384:114
8321:doi
8317:151
8280:PMC
8272:doi
8189:doi
8154:doi
8123:170
8086:doi
8010:PMC
8002:doi
7903:doi
7899:324
7862:PMC
7852:doi
7848:396
7811:PMC
7801:doi
7759:PMC
7751:doi
7639:PMC
7631:doi
7590:doi
7543:doi
7418:doi
7377:PMC
7369:doi
7296:PMC
7288:doi
7247:PMC
7239:doi
7199:PMC
7181:doi
7145:PMC
7135:doi
7131:176
7091:PMC
7081:doi
7069:111
7032:doi
7020:484
6991:doi
6939:PMC
6931:doi
6876:doi
6835:PMC
6825:doi
6778:doi
6741:PMC
6733:doi
6692:PMC
6684:doi
6643:doi
6639:214
6599:PMC
6589:doi
6548:PMC
6538:doi
6436:PMC
6428:doi
6383:doi
6379:154
6342:PMC
6332:doi
6291:doi
6252:doi
6202:doi
6198:122
6155:doi
6120:doi
6080:doi
6038:doi
6003:doi
5941:doi
5902:doi
5867:doi
5832:doi
5797:doi
5762:doi
5727:doi
5723:142
5690:doi
5686:113
5651:doi
5614:PMC
5606:doi
5567:doi
5503:doi
5482:doi
5478:111
5441:doi
5391:doi
5354:PMC
5346:doi
5305:doi
5255:doi
5218:doi
5162:doi
5119:doi
5083:doi
5015:doi
4976:doi
4972:120
4941:doi
4906:doi
4902:108
4864:doi
4820:doi
4774:doi
4770:108
4728:doi
4664:doi
4625:doi
4621:131
4578:doi
4531:doi
4488:doi
4484:151
4453:doi
4449:109
4416:PMC
4408:doi
4334:PMC
4324:doi
4254:doi
4250:140
4217:doi
4170:doi
4128:doi
4087:doi
4040:doi
4036:164
3970:doi
3926:PMC
3918:doi
3877:PMC
3869:doi
3828:doi
3787:PMC
3779:doi
3740:doi
3690:doi
3653:doi
3544:doi
3479:doi
3475:129
3436:doi
3405:147
3374:doi
3333:PMC
3325:doi
3273:doi
3269:324
3234:doi
3230:137
3188:doi
3153:doi
3149:110
3110:doi
3048:doi
3004:PMC
2996:doi
2892:PMC
2884:doi
2880:106
2814:PMC
2804:doi
2800:226
2763:PMC
2755:doi
2714:PMC
2704:doi
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2550:140
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2416:PMC
2408:doi
1828:);
1726:or
1619:).
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1546:or
1450:HLA
1423:BLK
1317:).
1313:or
1180:Eye
1125:of
1070:or
1062:or
1054:or
1009:CRP
771:or
686:BCG
684:at
627:CNS
567:CVS
551:MSS
491:GIT
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