38:
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Hopper, Christopher P.; De La Cruz, Ladie
Kimberly; Lyles, Kristin V.; Wareham, Lauren K.; Gilbert, Jack A.; Eichenbaum, Zehava; Magierowski, Marcin; Poole, Robert K.; Wollborn, Jakob; Wang, Binghe (2020-12-23).
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Penteado, Filipe; Lopes, Eric F.; Alves, Diego; Perin, Gelson; Jacob, Raquel G.; Lenardão, Eder J. (16 April 2019). "α-Keto Acids: Acylating Agents in
Organic Synthesis".
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Hewitson, K.S.; McNeill, L.A.; Elkins, J.M.; Schofield, C.J. (1 June 2003). "The role of iron and 2-oxoglutarate oxygenases in signalling".
310:
Franz
Dietrich Klingler, Wolfgang Ebertz "Oxocarboxylic Acids" in Ullmann's Encyclopedia of Industrial Chemistry 2005, Wiley-VCH, Weinheim.
96:). In several cases, the keto group is hydrated. The alpha-keto acids are especially important in biology as they are involved in the
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144:
331:
205:
Gamma-keto acids, Gamma-ketoacids, or 4-oxoacids have the ketone group at the third carbon from the carboxylic acid.
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Keto acids appear in a wide variety of anabolic pathways in metabolism. For instance, in plants (specifically, in
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Nelson, D. L.; Cox, M. M. "Lehninger, Principles of
Biochemistry" 3rd Ed. Worth Publishing: New York, 2000.
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194:, have the ketone group at the second carbon from the carboxylic acid. They generally form by the
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198:. The presence of the keto group at the beta position allows them to easily undergo thermal
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levels are low, stored fats and proteins are the primary source of energy production.
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225:), 5-oxo-octanoic acid is converted in enzymatic and non-enzymatic steps into the
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Kerber, Robert C.; Fernando, Marian S. (October 2010). "α-Oxocarboxylic Acids".
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have the keto group adjacent to the carboxylic acid. They often arise by
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Alpha keto acids are used primarily as energy for liver cells and in
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to the same. Alpha-keto acids possesses extensive chemistry as
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549:"5-Oxo-octanoic acid and 5-oxo-octanal, precursors of coniine"
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390:"Role of Carbon Monoxide in Host–Gut Microbiome Communication"
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Journal of the
Chemical Society D: Chemical Communications
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Beta-keto acids, beta-ketoacids, or 3-oxoacids, such as
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27:
Organic compounds with a –COOH group and a C=O group
267:can be deaminated to produce alpha keto acids and
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442:
131:agents. Furthermore, alpha-keto acids such as
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587:at the U.S. National Library of Medicine
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153:, pervasive intermediate in metabolism.
14:
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304:
173:. Alpha-ketoglutarate participates in
111:Alpha-keto acids, alpha-ketoacids, or
507:"Functional Group Exchange Reactions"
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147:scaffold. Important representatives:
107:Common types of keto acids include:
169:, a 5-carbon ketoacid derived from
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519:10.1016/b978-0-12-800720-4.00003-9
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547:Leete, E.; Olson, J. O. (1970).
472:Biochemical Society Transactions
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445:Journal of Chemical Education
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123:, and reciprocally, they are
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406:10.1021/acs.chemrev.0c00586
358:10.1021/acs.chemrev.8b00782
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135:are endogenous sources for
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621:
505:Smith, Michael B. (2017),
29:
513:, Elsevier, p. 137,
181:. It is commonly used in
589:Medical Subject Headings
316:10.1002/14356007.a18_313
30:Not to be confused with
167:alpha-ketoglutaric acid
98:Krebs citric acid cycle
249:Glucogenic amino acids
53:
278:, also in the liver.
265:Ketogenic amino acids
251:from proteins and/or
159:, a component of the
143:) and pharmaceutical
117:oxidative deamination
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561:10.1039/C29700001651
276:fatty acid synthesis
196:Claisen condensation
177:by functioning as a
400:(24): 13273–13311.
484:10.1042/bst0310510
133:phenylpyruvic acid
54:
555:(23): 1651–1652.
528:978-0-12-800720-4
511:Organic Synthesis
457:10.1021/ed1003096
451:(10): 1079–1084.
352:(12): 7113–7278.
259:are converted to
78:organic compounds
58:organic chemistry
16:(Redirected from
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346:Chemical Reviews
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192:acetoacetic acid
157:oxaloacetic acid
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46:acetoacetic acid
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200:decarboxylation
141:gasotransmitter
137:carbon monoxide
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80:that contain a
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579:External links
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288:Ulosonic acids
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239:When ingested
223:fool's parsley
219:pitcher plants
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209:is an example.
207:Levulinic acid
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183:transamination
175:cell signaling
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68:(also called
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245:carbohydrate
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151:pyruvic acid
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42:Pyruvic acid
161:Krebs cycle
121:amino acids
605:Keto acids
585:Keto+Acids
534:2022-06-01
299:References
293:Pseudoacid
185:reactions.
125:precursors
113:2-oxoacids
102:glycolysis
62:keto acids
569:0577-6171
430:224824871
414:0009-2665
374:119535331
234:alkaloids
229:class of
129:acylation
70:oxo acids
66:ketoacids
599:Category
492:12773146
422:33089988
366:30990680
282:See also
253:Glycerol
179:coenzyme
88:) and a
74:oxoacids
52:(bottom)
18:Ketoacid
261:glucose
231:coniine
215:hemlock
145:prodrug
100:and in
94:>C=O
92:group (
84:group (
44:(top),
32:oxyacid
591:(MeSH)
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428:
420:
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372:
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241:sugars
227:cyclic
221:, and
139:(as a
90:ketone
76:) are
426:S2CID
370:S2CID
255:from
86:−COOH
565:ISSN
523:ISBN
488:PMID
418:PMID
410:ISSN
362:PMID
328:ISBN
243:and
48:and
557:doi
515:doi
480:doi
453:doi
402:doi
398:120
354:doi
350:119
312:doi
119:of
72:or
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