Atorvastatin - Knowledge

1625:(AUC). This finding initially gave rise to concerns of toxicity, and in 2000, it was recommended that people taking atorvastatin should not consume grapefruit juice "in an unsupervised manner." Small studies (using mostly young participants) examining the effects of grapefruit juice consumption on mainly lower doses of atorvastatin have shown that grapefruit juice increases blood levels of atorvastatin, which could increase the risk of adverse effects. No studies assessing the impact of grapefruit juice consumption have included participants taking the highest dose of atorvastatin (80 mg daily), which is often prescribed for people with a history of 1198:) on atorvastatin has revealed that it may still be beneficial in reducing combined cardiac events, cardiac and all-cause mortality in those with a higher baseline LDL cholesterol >3.75 mmol/L. While the SHARP study suggested that LDL cholesterol-lowering treatments (e.g. statin/ezetimibe combination) are effective in reducing the risks of major atherosclerotic events in people with CKD including those on dialysis, the subgroup analysis of the people undergoing hemodialysis had revealed no significant benefits. Whether or not hemodialysis has any impact on the statin levels was not specifically addressed in these major trials. 2003: 1991: 1167:

lowering LDL cholesterol if taken in the evening. However, the only study included in the meta-analysis of atorvastatin in people with heart disease did not specifically investigate if morning or evening dosing was more effective for reducing LDL cholesterol. The trial did confirm that, irrespective of dosing time, atorvastatin is very effective at reducing total cholesterol, LDL cholesterol and triglycerides, and increasing HDL cholesterol levels. Hence, atorvastatin should be taken at the same time each day, at a time that is most convenient for the patient, so it does not compromise compliance.

1147:

catheterisation, coronary angiography (CAG) or percutaneous coronary intervention (PCI). A meta-analysis of 21 RCTs confirmed that high dose (80 mg) atorvastatin therapy is more effective than regular dose or low dose statin therapy at preventing CI-AKI. Atorvastatin therapy can also help to prevent in-hospital dialysis post CM administration, however there is no evidence that it reduces all-cause mortality associated with CI-AKI. Overall, the evidence concludes that statin therapy, irrespective of the dose, is still more effective than no treatment or placebo at reducing the risk of CI-AKI.

769: 746: 51: 1982:

genotype when treated with atorvastatin. Another genetic variant that showed genome wide significance in Caucasians was the SNP rs10455872 in the LPA gene that lead to higher Lp(a) levels which cause an apparent lower LDL-c response to atorvastatin. These studies were in Caucasian population, more research with a large cohort need to be conducted in different ethnicities to identify more polymorphisms that can affect atorvastatin pharmacokinetics and treatment response.

1742: 1637:) or in people at high risk of cardiovascular disease. People taking atorvastatin should consult with their doctor or pharmacist before consuming grapefruit juice, as the effects of grapefruit juice consumption on atorvastatin will vary according to factors such as the amount and frequency of juice consumption in addition to differences in juice components, quality and method of juice preparation between different batches or brands. 2162: 1311:

benefits of statin therapy in preventing fatal and non-fatal stroke, fatal coronary heart disease, and non-fatal myocardial infarction are significant. For most people the benefits of statin therapy far outweigh the risk of developing diabetes. A 2010 meta-analysis demonstrated that every 255 people treated with a statin for four years produced a reduction of 5.4 major coronary events and induced only one new case of diabetes.

1315:

low increase in muscle pain and weakness was present (5%) with no clear evidence of a dose-response relationship. Duration of treatment with atorvastatin is unlikely to increase the risk of muscle-related side effects as most occur within the first year of treatment, after which the risk is not increased further. The known cardiovascular benefits of atorvastatin over time outweigh the low risk of muscle-related side effects.

42: 8645: 1715:, high-dose atorvastatin treatment may play a plaque-stabilizing role. At high doses, statins have anti-inflammatory effects, incite reduction of the necrotic plaque core, and improve endothelial function, leading to plaque stabilization and, sometimes, plaque regression. There is a similar thought process with using high-dose atorvastatin as a form of secondary 6903: 2103:– was in the advanced stages of development. Nevertheless, Bruce Roth and his bosses, Roger Newton and Ronald Cresswell, in 1985, convinced company executives to move the compound into expensive clinical trials. Early results comparing atorvastatin to simvastatin demonstrated that atorvastatin appeared more potent and with fewer side effects. 6735:

Roth BD, Blankley CJ, Chucholowski AW, Ferguson E, Hoefle ML, Ortwine DF, et al. (1991). "Inhibitors of Cholesterol Biosynthesis. 3. Tetrahydro-4-hydroxy-6--2H-pyran 2-one Inhibitors of HMG-CoA Reductase. 2. Effects of Introducing Substituents at Positions Three and Four of the Pyrrole Nucleus".

2207:

Ltd. voluntarily recalled 10-, 20- and 40-mg doses of its generic version of atorvastatin in the United States. The lots of atorvastatin, packaged in bottles of 90 and 500 tablets, were recalled due to possible contamination with very small glass particles similar to the size of a grain of sand (less

2049:

developed a cost-effective and scalable synthesis. In atorvastatin's case, a key element of the overall synthesis was ensuring stereochemical purity in the final drug substance, and hence establishing the first stereocenter became a key aspect of the overall design. The final commercial production of

1727:

The liver is the primary site of action of atorvastatin, as this is the principal site of both cholesterol synthesis and LDL clearance. It is the dosage of atorvastatin, rather than systemic medication concentration, which correlates with extent of LDL-C reduction. In a Cochrane systematic review the

2187:

In other countries, atorvastatin calcium is made in tablet form by generic medication makers under various brand names including Atoris, Atorlip, Atorva, Atorvastatin Teva, Atorvastatina Parke-Davis, Avas, Cardyl, Liprimar, Litorva, Mactor, Orbeos, Prevencor, Sortis, Stator, Tahor, Torid, Torvacard,

1327:

be assessed with laboratory tests before beginning atorvastatin treatment and repeated periodically as clinically indicated - usually a clinicians' judgement. Package inserts for this statin recommend actions should liver abnormalities be detected. Ultimately, this is the judgment of the prescribing

1314:

In some case and clinical studies mild muscle pain or weakness have been reported (around 3%), compared to a placebo. However, this increase was not related to statin therapy in 90% of cases in a large meta-analysis of randomized controlled trials. In patients taking higher statin doses, a similarly

1322:

Persistent liver enzyme abnormalities (usually elevated in hepatic transaminases) have been documented. Elevations threefold greater than normal were recorded in 0.5% of people treated with atorvastatin 10 mg-80 mg rather than placebo. Usage instructions in package inserts for this statin

1310:

is observed in a small number of people, and is an uncommon class effect of all statins. It appears it may be more likely in people who were already at a higher risk of developing diabetes before starting a statin due to multiple risk factors, for example raised fasting glucose levels. However, the

4624:

Sever PS, Dahlöf B, Poulter NR, Wedel H, Beevers G, Caulfield M, et al. (April 2003). "Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid

1981:

There are several studies showing genetic variants and variable response to atorvastatin. The polymorphisms that showed genome wide significance in Caucasian population were the SNPs in the apoE region; rs445925, rs7412, rs429358 and rs4420638 which showed variable LDL-c response depending on the

1386:

There have been rare reports of reversible memory loss and confusion with all statins, including atorvastatin; however, there has not been enough evidence to associate statin use with cognitive impairment, and the risks for cognition are likely outweighed by the beneficial effects of adherence to

1142:

There is evidence from systematic review and meta-analyses that statins, particularly atorvastatin, reduce both decline in kidney function (eGFR) and the severity of protein excretion in urine, with higher doses having greater effect. Data are conflicting for whether statins reduce risk of kidney

1190:

Hemodialysis: Although there has been moderate-to-high quality of evidence to show the lack of clear and significant clinical benefits of statins (including atorvastatin at a dose of 20mg) minimizing non-fatal myocardial infarction, stroke, and cardiovascular mortality in adults on hemodialysis

1377:

Atorvastatin has been associated with a small increase in fasting blood glucose levels over a 2-year period, particularly in patients with Type 2 Diabetes, however evidence is conflicting and clinical significance of this increase has not been determined. Regular blood glucose monitoring may be

1166:

Statins with shorter half-lives are more effective when taken in the evening, so their peak effect occurs when the body’s natural cholesterol production is at its highest. A recent meta-analysis suggested that statins with longer half-lives, including atorvastatin, may also be more effective at

1318:

Statin-induced rhabdomyolysis is rare, occurring in less than 0.1% of people who take statins. Statin induced rhabdomyolysis, as with other statin associated muscle symptoms, occurs most commonly in the first year of treatment but can occur at any time during treatment. Risk factors for statin

1146:

Prior to contrast medium (CM) administration, pre-treatment with atorvastatin therapy can reduce the risk of contrast-induced acute kidney injury (CI-AKI) in people with pre-existing chronic kidney disease (CKD) (eGFR < 60mL/min/1.73m2) who undergo interventional procedures such as cardiac

1191:(including those with diabetes and/or pre-existing cardiovascular diseases) despite the clinically relevant reduction in total/LDL cholesterol levels, there is evidence that people undergoing hemodialysis who received moderate intensity statin therapy had a lower risk of all-cause mortality. 3004:

Colhoun HM, Betteridge DJ, Durrington PN, Hitman GA, Neil HA, Livingstone SJ, et al. (2004). "Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial".

1176:

Geriatric: Plasma concentrations of atorvastatin in healthy elderly subjects are higher than those in young adults. However, clinical data suggests there is a similar reduction of LDL cholesterol and cardiovascular events at any dose in this population and adults younger than 65 years of

2212:

mm in size). The FDA received no reports of injury from the contamination. Ranbaxy also issued recalls of bottles of 10-milligram tablets in August 2012 and March 2014, due to concerns that the bottles might contain larger, 20-milligram tablets and thus cause potential dosing errors.

1242:: Small amounts of other statin medications have been found to pass into breast milk, although atorvastatin has not been studied specifically. Due to risk of disrupting a breastfeeding infant's metabolism of lipids, atorvastatin is not regarded as compatible with breastfeeding. 7756: 3747:

Ozaydin M, Dede O, Dogan A, Aslan SM, Altinbas A, Ozturk M, et al. (January 2006). "Effects of morning versus evening intake of atorvastatin on major cardiac event and restenosis rates in patients undergoing first elective percutaneous coronary intervention".

2120:

billion. Lipitor was on the market by 1996. By 2003, Lipitor had become the best selling pharmaceutical in the United States. From 1996 to 2012, under the trade name Lipitor, atorvastatin became the world's best-selling medication of all time, with more than $

1205:. Despite these concerns, a 2017 systematic review and analysis of available evidence has shown that statins, such as atorvastatin, are relatively safe to use in stable, asymptomatic cirrhosis and may even reduce the risk of liver disease progression and death. 3819:

Olsson AG, Schwartz GG, Szarek M, Luo D, Jamieson MJ (March 2007). "Effects of high-dose atorvastatin in patients > or =65 years of age with acute coronary syndrome (from the myocardial ischemia reduction with aggressive cholesterol lowering study)".

3616:

Keech A, Simes RJ, Barter P, Best J, Scott R, Taskinen MR, et al. (November 2005). "Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial".

3089:

Gentile S, Turco S, Guarino G, Sasso CF, Amodio M, Magliano P, et al. (December 2000). "Comparative efficacy study of atorvastatin vs simvastatin, pravastatin, lovastatin and placebo in type 2 diabetic patients with hypercholesterolaemia".

2083:, who was hired by Warner-Lambert as a chemist in 1982, had synthesized an "experimental compound" codenamed CI 981 – later called atorvastatin. It was first made in August 1985. Warner-Lambert management was concerned that atorvastatin was a 2672:

Nawrocki JW, Weiss SR, Davidson MH, Sprecher DL, Schwartz SL, Lupien PJ, et al. (May 1995). "Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor".

3354:

Xiong B, Nie D, Cao Y, Zou Y, Yao Y, Qian J, et al. (November 2017). "Preoperative Statin Treatment for the Prevention of Acute Kidney Injury in Patients Undergoing Cardiac Surgery: A Meta-Analysis of Randomised Controlled Trials".

1093:

of heart attack, stroke, and need for revascularization procedures in people who have risk factors such as age, smoking, high blood pressure, low HDL-C, and a family history of early heart disease, but have not yet developed evidence of

1728:

dose-related magnitude of atorvastatin on blood lipids was determined. Over the dose range of 10 to 80 mg/day total cholesterol was reduced by 27.0% to 37.9%, LDL cholesterol by 37.1% to 51.7% and triglycerides by 18.0% to 28.3%.

2112:

concluding the efficacy of statins in lowering cholesterol proving for the first time not only that a "statin reduced 'bad' LDL cholesterol but also that it led to a sharp drop in fatal heart attacks among people with heart disease."

2968:

Nissen SE, Tuzcu EM, Schoenhagen P, Brown BG, Ganz P, Vogel RA, et al. (March 2004). "Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial".

3310:

Amarenco P, Callahan A, Campese VM, Goldstein LB, Hennerici MG, Messig M, et al. (October 2014). "Effect of high-dose atorvastatin on renal function in subjects with stroke or transient ischemic attack in the SPARCL trial".

7746: 3397:

Zhou X, Dai J, Xu X, Wang Z, Xu H, Chen J, et al. (April 2019). "Comparative Efficacy of Statins for Prevention of Contrast-Induced Acute Kidney Injury in Patients With Chronic Kidney Disease: A Network Meta-Analysis".

2600:

McCrindle BW, Ose L, Marais AD (July 2003). "Efficacy and safety of atorvastatin in children and adolescents with familial hypercholesterolemia or severe hyperlipidemia: a multicenter, randomized, placebo-controlled trial".

1977:

may be linked to an increase in statin-related side effects with single nucleotide polymorphisms (SNPs) in the SLCO1B1 gene showing a 45 fold higher incidence of statin related myopathy than people without the polymorphism.

2845:

Mills EJ, Wu P, Chong G, Ghement I, Singh S, Akl EA, et al. (February 2011). "Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170,255 patients from 76 randomized trials".

2708:

Bakker-Arkema RG, Davidson MH, Goldstein RJ, Davignon J, Isaacsohn JL, Weiss SR, et al. (January 1996). "Efficacy and safety of a new HMG-CoA reductase inhibitor, atorvastatin, in patients with hypertriglyceridemia".

5963:"Recommendations for Management of Clinically Significant Drug-Drug Interactions With Statins and Select Agents Used in Patients With Cardiovascular Disease: A Scientific Statement From the American Heart Association" 883:

InChI=1S/C33H35FN2O5/c1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40)/t26-,27-/m1/s1

1930:

of 14 hours. Noteworthy, the HMG-CoA reductase inhibitory activity appears to have a half-life of 20–30 hours, which is thought to be due to the active metabolites. Atorvastatin is also a substrate of the intestinal

1964:

values that are 40% and 30% higher, respectively. Additionally, healthy elderly people show a greater pharmacodynamic response to atorvastatin at any dose; therefore, this population may have lower effective doses.

7303: 3783:

Collier DJ, Poulter NR, Dahlöf B, Sever PS, Wedel H, Buch J, et al. (March 2011). "Impact of atorvastatin among older and younger patients in the Anglo-Scandinavian Cardiac Outcomes Trial Lipid-Lowering Arm".

841: 1589:

states that the combination of digoxin and atorvastatin is reasonable. In contrast to some other statins, atorvastatin does not interact with warfarin concentrations in a clinically meaningful way (similar to

1186:

Kidney impairment: Kidney disease has no statistically significant influence on plasma concentrations of atorvastatin and dose adjustment considerations should only be made in context of the patient's overall

5787:

Mazzu AL, Lasseter KC, Shamblen EC, Agarwal V, Lettieri J, Sundaresen P (October 2000). "Itraconazole alters the pharmacokinetics of atorvastatin to a greater extent than either cerivastatin or pravastatin".

2636:

Nissen SE, Nicholls SJ, Sipahi I, Libby P, Raichlen JS, Ballantyne CM, et al. (April 2006). "Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial".

1891:. As a substrate for the CYP3A4 isozyme, it has shown susceptibility to inhibitors and inducers of CYP3A4 to produce increased or decreased plasma concentrations, respectively. This interaction was tested 7688: 4923:

Amarenco P, Bogousslavsky J, Callahan A, Goldstein LB, Hennerici M, Rudolph AE, et al. (Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Investigators) (August 2006).

1116:

in people with established coronary artery disease. The effect is dose dependent and is amplified at higher doses. Close monitoring of liver function tests is required when high doses is used.

4371: 4491:

Sattar N, Preiss D, Murray HM, Welsh P, Buckley BM, de Craen AJ, et al. (February 2010). "Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials".

3855:

Wenger NK, Lewis SJ, Herrington DM, Bittner V, Welty FK (July 2007). "Outcomes of using high- or low-dose atorvastatin in patients 65 years of age or older with stable coronary heart disease".

5752:

Wägner AM, Jorba O, Bonet R, Ordóñez-Llanos J, Pérez A (July 2003). "Efficacy of atorvastatin and gemfibrozil, alone and in low dose combination, in the treatment of diabetic dyslipidemia".

4156:"The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial" 6997:

Scandinaviansimvastatinsurvival (November 1994). "Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)".

5539:

Graham DJ, Staffa JA, Shatin D, Andrade SE, Schech SD, La Grenade L, et al. (December 2004). "Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs".

1163:

to manage dyslipidemia in people who also have type 2 diabetes, and a high cardiovascular disease risk; however, there is limited clinical benefit noted for most cardiovascular outcomes.

6975: 1994:

Atorvastatin synthesis in commercial production (process) chemistry. The key step of establishing this medication's stereocenters, through initial use of an inexpensive natural product (

7723: 7270: 7442: 355: 5874:

Backman JT, Luurila H, Neuvonen M, Neuvonen PJ (August 2005). "Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolites".

2184:. Prices for the generic version did not drop to the level of other generics—$ 10 or less for a month's supply—until other manufacturers began to supply the medication in May 2012. 3709:

Maqsood MH, Messerli FH, Waters D, Skolnick AH, Maron DJ, Bangalore S (October 2022). "Timing of statin dose: a systematic review and meta-analysis of randomized clinical trials".

2263: 2884:

LaRosa JC, Grundy SM, Waters DD, Shear C, Barter P, Fruchart JC, et al. (April 2005). "Intensive lipid lowering with atorvastatin in patients with stable coronary disease".

1319:

induced rhabdomyolysis include older age, renal impairment, high dose statins and use of medications that reduce the breakdown of statins (such as CYP3A4 inhibitors) or fibrates.

5709:

Geng Q, Ren J, Chen H, Lee C, Liang W (March 2013). "Adverse events following statin-fenofibrate therapy versus statin alone: a meta-analysis of randomized controlled trials".

3931:

Stern RH, Yang BB, Horton M, Moore S, Abel RB, Olson SC (September 1997). "Renal dysfunction does not alter the pharmacokinetics or LDL-cholesterol reduction of atorvastatin".

1942:, plasma concentrations of atorvastatin are significantly affected by concurrent liver disease. People with Child-Pugh Stage A liver disease show a four-fold increase in both C 1183:

Gender: Plasma concentrations are generally higher in women than in men, but there is no clinically significant difference in the extent of LDL reduction between men and women.

5094:

Sukhija R, Prayaga S, Marashdeh M, Bursac Z, Kakar P, Bansal D, et al. (March 2009). "Effect of statins on fasting plasma glucose in diabetic and nondiabetic patients".

3448:"Comparative efficacy of pharmacological interventions for contrast-induced nephropathy prevention after coronary angiography: a network meta-analysis from randomized trials" 7814:"The $ 10 Billion Pill Hold the fries, please. Lipitor, the cholesterol-lowering medication, has become the bestselling pharmaceutical in history. Here's how Pfizer did it" 6834:"The $ 10 Billion Pill Hold the fries, please. Lipitor, the cholesterol-lowering medication, has become the bestselling pharmaceutical in history. Here's how Pfizer did it" 2488: 7292: 6805: 2332: 7536: 7144: 2785:

Marais AD, Firth JC, Bateman ME, Byrnes P, Martens C, Mountney J (August 1997). "Atorvastatin: an effective lipid-modifying agent in familial hypercholesterolemia".

1700:. This increases LDL uptake by the hepatocytes, decreasing the amount of LDL-cholesterol in the blood. Like other statins, atorvastatin also reduces blood levels of 7203: 6936: 6642:

Thompson JF, Man M, Johnson KJ, Wood LS, Lira ME, Lloyd DB, et al. (2005). "An association study of 43 SNPs in 16 candidate genes with atorvastatin response".

6292:

Liberale L, Carbone F, Montecucco F, Sahebkar A (May 2020). "Statins reduce vascular inflammation in atherogenesis: A review of underlying molecular mechanisms".

7336: 5674:

Enger C, Gately R, Ming EE, Niemcryk SJ, Williams L, McAfee AT (December 2010). "Pharmacoepidemiology safety study of fibrate and statin concomitant therapy".

4873:"Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12,064 survivors of myocardial infarction: a double-blind randomised trial" 1581:, leading to alterations in effect or a requirement for clinical monitoring. The increase in digoxin levels due to atorvastatin is a 1.2 fold elevation in the 8251: 6010:

Schwartz JB (February 2009). "Effects of vitamin D supplementation in atorvastatin-treated patients: a new drug interaction with an unexpected consequence".

1458:, may increase serum concentrations of atorvastatin, which may lead to adverse reactions. This is less likely to happen with other CYP3A4 inhibitors such as 230: 7674: 5059:

Newman CB, Palmer G, Silbershatz H, Szarek M (September 2003). "Safety of atorvastatin derived from analysis of 44 completed trials in 9,416 patients".

6267: 2169:

Atorvastatin calcium tablets are sold under the brand name Lipitor. Pfizer also packages the medication in combination with other medications, such as

7651: 7086: 5188:"Effect of atorvastatin on glycaemia progression in patients with diabetes: an analysis from the Collaborative Atorvastatin in Diabetes Trial (CARDS)" 3135:"Impact of statin therapy on coronary plaque composition: a systematic review and meta-analysis of virtual histology intravascular ultrasound studies" 6201:

Lilja JJ, Kivistö KT, Neuvonen PJ (August 1999). "Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin".

4309: 7359: 7878: 4333:"Exposure of atorvastatin is unchanged but lactone and acid metabolites are increased several-fold in patients with atorvastatin-induced myopathy" 1899:, a known CYP3A4 isozyme inhibitor, which resulted in increased plasma concentrations of atorvastatin. It is also an inhibitor of cytochrome 3A4. 7262: 7174: 7118: 2116:

In 1996, Warner-Lambert entered into a co-marketing agreement with Pfizer to sell Lipitor, and in 2000, Pfizer acquired Warner-Lambert for $ 90.2

1423:

in combination with statins or as monotherapy. While studies have suggested that the combined use of statins and the fibrate drug class (such as

7114: 2921:"Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis" 6965: 4673:"Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials" 2149:(PPACA) in the United States, health plans may cover the costs of atorvastatin 10 mg and 20 mg for adults aged 40–75 years based on 7712: 7386: 2569: 2445:

The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023)

1853:

of atorvastatin is approximately 381 L. It is highly protein bound (≥98%), and studies have shown it is likely secreted in human breastmilk.

127: 7513: 6873: 7450: 4722:"Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials" 4448:

Thakker D, Nair S, Pagada A, Jamdade V, Malik A (October 2016). "Statin use and the risk of developing diabetes: a network meta-analysis".

4205:"Statin Use and Risk of Cirrhosis and Related Complications in Patients With Chronic Liver Diseases: A Systematic Review and Meta-analysis" 2150: 855: 7420: 2006:

Atorvastatin synthesis during discovery chemistry. The key step of establishing stereocenters, using of a chiral ester auxiliary approach.

2418: 4332: 3892:"Pharmacokinetics of atorvastatin and its metabolites after single and multiple dosing in hypercholesterolaemic haemodialysis patients" 2573: 2379: 2146: 3516:"Beneficial effect of statin on preventing contrast-induced acute kidney injury in patients with renal insufficiency: A meta-analysis" 8545: 1072: 5831:

Neuvonen PJ, Niemi M, Backman JT (December 2006). "Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance".

1395:

A 2012 meta-analysis found that statin therapy might reduce the risk of pancreatitis in people with normal or mildly elevated blood

1065: 8130: 7480: 5504:

Cui Y, Zong H, Yan H, Zhang Y (June 2014). "The effect of statins on erectile dysfunction: a systematic review and meta-analysis".

3050:"Analysis of efficacy and safety in patients aged 65–75 years at randomization: Collaborative Atorvastatin Diabetes Study (CARDS)" 1818:, which is the main cause for the low systemic availability. Administration of atorvastatin with food produces a 25% reduction in 1265:. When rhabdomyolysis is suspected or diagnosed, atorvastatin therapy is discontinued immediately. The likelihood of developing a 1826: 1622: 1582: 1130:

therapy was significantly superior compared to moderate or low-intensity statin therapy in reducing plaque volume in people with

7540: 6797: 2324: 2129:

years. and $ 13 billion a year at its peak, Lipitor alone "provided up to a quarter of Pfizer Inc.'s annual revenue for years."

7840: 7620: 7053: 2241: 2054:

approach, where the stereochemistry of the first alcohol functional group was carried into the synthesis—through the choice of

8599: 6781: 6711: 5469:

Kostis JB, Dobrzynski JM (July 2014). "The effect of statins on erectile dysfunction: a meta-analysis of randomized trials".

2829: 2518: 2482: 1050: 1008: 968: 7871: 1614:

components are known inhibitors of intestinal CYP3A4. Drinking grapefruit juice with atorvastatin may cause an increase in

1059: 7140: 6921: 1134:. The SATURN trial, which compared the effects of high-dose atorvastatin and rosuvastatin, also confirmed these findings. 7240: 7196: 4819:"Unintended effects of statins from observational studies in the general population: systematic review and meta-analysis" 4577:"Predictors of new-onset diabetes in patients treated with atorvastatin: results from 3 large randomized clinical trials" 3486: 1841:

and AUC by 30% each. However, time of administration does not affect the plasma LDL-C-lowering efficacy of atorvastatin.

5444: 5390: 932:

Common side effects include joint pain, diarrhea, heartburn, nausea, and muscle pains. Serious side effects may include

900: 178: 8685: 7813: 6833: 6586:"Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a)" 2176:

Pfizer's U.S. patent on Lipitor expired on 30 November 2011. Initially, generic atorvastatin was manufactured only by

8675: 7328: 2412: 1799:

Atorvastatin undergoes rapid absorption when taken orally, with an approximate time to maximum plasma concentration (

1781: 1483: 875: 8616: 7909: 4405:

Williams D, Feely J (2002). "Pharmacokinetic-pharmacodynamic drug interactions with HMG-CoA reductase inhibitors".

7263:"Recommendation: Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Preventive Medication" 1236:: Atorvastatin is unlikely to cause fetal anomalies but may be associated with low birth weight and preterm labor. 7864: 2188:

Torvast, Totalip, Tulip, Xarator, and Zarator. Pfizer also makes its own generic version under the name Zarator.

487: 340: 159: 1020: 1016: 6901:, Roth BD, "Trans-6--4-hydroxypyran-2-one inhibitors of cholesterol synthesis", issued 21 July 1987 3272:

Geng Q, Ren J, Song J, Li S, Chen H (August 2014). "Meta-analysis of the effect of statins on renal function".

1763: 5288:"Use of statins and the risk of dementia and mild cognitive impairment: A systematic review and meta-analysis" 2099:). Mevacor, which was first marketed in 1987, was the industry's first statin and Merck's synthetic version – 566: 1759: 1550:; these increases should be considered when selecting an oral contraceptive for a woman taking atorvastatin. 2746:"The anti-atherosclerotic effects of lipid lowering with atorvastatin in patients with hypercholesterolemia" 1935:

efflux transporter, which pumps the medication back into the intestinal lumen during medication absorption.

8680: 8134: 7900: 7643: 7616: 7082: 7075: 4107:"Atorvastatin and low-density lipoprotein cholesterol in type 2 diabetes mellitus patients on hemodialysis" 2019: 967:

Atorvastatin was patented in 1986, and approved for medical use in the United States in 1996. It is on the

764: 617: 5186:

Livingstone SJ, Looker HC, Akbar T, Betteridge DJ, Durrington PN, Hitman GA, et al. (February 2016).

4301: 1510:, which are CYP3A4 inducers, can decrease the plasma concentrations of atorvastatin. Only rarely, though, 7363: 6428:

Gaspardone A, Arca M (1 November 2007). "Atorvastatin: its clinical role in cerebrovascular prevention".

1960:

years old) exhibit altered pharmacokinetics of atorvastatin compared to young adults, with mean AUC and C

725: 4969:"A Narrative Review of Statin-Induced Rhabdomyolysis: Molecular Mechanism, Risk Factors, and Management" 8635: 7166: 6694:

Roth BD (2002). "1 the Discovery and Development of Atorvastatin, A Potent Novel Hypolipidemic Agent".

6584:

Deshmukh HA, Colhoun HM, Johnson T, McKeigue PM, Betteridge DJ, Durrington PN, et al. (May 2012).

2027: 1586: 686: 6898: 6524:"Genetic factors affecting statin concentrations and subsequent myopathy: a HuGENet systematic review" 2034:

to set the stereochemistry of the first of the two alcohol functional groups via a diastereoselective

1253:

is suspected or diagnosed after dosing of atorvastatin has begun. Very rarely, atorvastatin may cause

8560: 7507: 7229:"Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Recommendation Statement" 6151:"Serum concentrations and clinical effects of atorvastatin in patients taking grapefruit juice daily" 4015:

Fellström BC, Jardine AG, Schmieder RE, Holdaas H, Bannister K, Beutler J, et al. (April 2009).

2440: 2002: 1923: 1671: 5237:"Do statins impair cognition? A systematic review and meta-analysis of randomized controlled trials" 8459: 8425: 8340: 8082: 3184:

Nicholls SJ, Ballantyne CM, Barter PJ, Chapman MJ, Erbel RM, Libby P, et al. (December 2011).

3048:

Neil HA, DeMicco DA, Luo D, Betteridge DJ, Colhoun HM, Durrington PN, et al. (November 2006).

2042: 1705: 1143:

failure. Statins, including atorvastatin, before heart surgery do not prevent acute kidney injury.

1044: 741: 7390: 6862: 6245: 4871:

Armitage J, Bowman L, Wallendszus K, Bulbulia R, Rahimi K, Haynes R, et al. (November 2010).

1337:

The following have been shown to occur in 1–10% of people taking atorvastatin in clinical trials:

975:. In 2022, it was the most commonly prescribed medication in the United States, with more than 109 8604: 8484: 8479: 8454: 8421: 8383: 8167: 8086: 8022: 7949: 7835: 7718: 7502: 7446: 7048: 3133:

Banach M, Serban C, Sahebkar A, Mikhailidis DP, Ursoniu S, Ray KK, et al. (September 2015).

2170: 1990: 1830: 1752: 1712: 1557: 1131: 1095: 1078: 1028: 394: 216: 117: 17: 6149:

Reddy P, Ellington D, Zhu Y, Zdrojewski I, Parent SJ, Harmatz JS, et al. (September 2011).

6097:

Ando H, Tsuruoka S, Yanagihara H, Sugimoto K, Miyata M, Yamazoe Y, et al. (November 2005).

925:. For the prevention of cardiovascular disease, statins are a first-line treatment. It is taken 8700: 8469: 8464: 7412: 4671:

Baigent C, Blackwell L, Emberson J, Holland LE, Reith C, Bhala N, et al. (November 2010).

1850: 1626: 1220: 992: 918: 707: 6772:

Li JJ, Johnson DS, Sliskovic DR, Roth BD (2004). "Chapter 9. Atorvastatin Calcium (Lipitor)".

4720:

Reith C, Baigent C, Blackwell L, Emberson J, Spata E, Davies K, et al. (September 2022).

3567:"Meta-analysis of rosuvastatin efficacy in prevention of contrast-induced acute kidney injury" 2472: 2402: 2264:"Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017" 666: 8474: 7941: 7747:"Indian drugmaker Ranbaxy recalls more than 64,000 bottles of its generic version of Lipitor" 5345:

Samaras K, Makkar SR, Crawford JD, Kochan NA, Slavin MJ, Wen W, et al. (November 2019).

5018:

Kashani A, Phillips CO, Foody JM, Wang Y, Mangalmurti S, Ko DT, et al. (December 2006).

3890:

Lins RL, Matthys KE, Verpooten GA, Peeters PC, Dratwa M, Stolear JC, et al. (May 2003).

1883:

metabolites. The ortho- and parahydroxylated metabolites are responsible for 70% of systemic

1815: 1679: 1630: 1289: 1105: 557: 7562: 5235:

Ott BR, Daiello LA, Dahabreh IJ, Springate BA, Bixby K, Murali M, et al. (March 2015).

3868: 2565: 2371: 1922:

elimination follows hepatic and/or extrahepatic metabolism. There does not appear to be any

521: 8515: 8241: 8100: 5299: 5020:"Risks associated with statin therapy: a systematic overview of randomized clinical trials" 4776:

LaRosa JC, Grundy SM, Waters DD, Shear C, Barter P, Fruchart JC, et al. (April 2005).

4154:

Baigent C, Landray MJ, Reith C, Emberson J, Wheeler DC, Tomson C, et al. (June 2011).

2204: 2181: 2065: 2015: 1974: 1556:

can rarely decrease the plasma concentrations of statin medications, but do not affect the

1408: 1101: 1004: 626: 606: 454: 5961:

Wiggins BS, Saseen JJ, Page RL, Reed BN, Sneed K, Kostis JB, et al. (November 2016).

1538:, which are also CYP3A4 inducers, can decrease the plasma concentrations of atorvastatin. 1439:, there is insufficient evidence to firmly establish this association with atorvastatin. 8: 7887: 7751: 7584: 6338:

Rosa GM, Carbone F, Parodi A, Massimelli EA, Brunelli C, Mach F, et al. (May 2014).

5139:"Statin therapy on glycemic control in type 2 diabetic patients: A network meta-analysis" 4575:

Waters DD, Ho JE, DeMicco DA, Breazna A, Arsenault BJ, Wun CC, et al. (April 2011).

3660:

Ginsberg HN, Elam MB, Lovato LC, Crouse JR, Leiter LA, Linz P, et al. (April 2010).

1819: 1615: 1258: 512: 223: 7472: 5303: 768: 745: 8499: 7945: 7818: 7022: 6970: 6838: 6667: 6612: 6548: 6523: 6499: 6453: 6369: 6317: 6226: 6175: 6150: 6123: 6098: 6035: 5992: 5899: 5856: 5813: 5734: 5656: 5608: 5583: 5564: 5412:

Preiss D, Tikkanen MJ, Welsh P, Ford I, Lovato LC, Elam MB, et al. (August 2012).

5322: 5263: 5212: 5187: 5168: 5119: 4995: 4968: 4897: 4872: 4845: 4746: 4721: 4697: 4672: 4650: 4606: 4516: 4473: 4430: 4363: 4278: 4269: 4253: 4229: 4204: 4180: 4155: 4131: 4106: 4082: 4057: 3956: 3944: 3686: 3661: 3642: 3593: 3542: 3478: 3423: 3336: 3161: 3115: 3030: 1667: 1539: 1090: 1040: 972: 189: 7796: 7010: 6703: 6099:"Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin" 5072: 5036: 5019: 4888: 4737: 4688: 4638: 4552: 4535: 4504: 4331:

Hermann M, Bogsrud MP, Molden E, Asberg A, Mohebi BU, Ose L, et al. (June 2006).

4171: 3630: 3018: 2945: 2920: 2744:

Ozaki K, Kubo T, Imaki R, Shinagawa H, Fukaya H, Ohtaki K, et al. (August 2006).

2614: 8690: 8665: 8494: 8163: 8120: 8018: 7800: 7612: 7014: 6777: 6754: 6717: 6707: 6659: 6617: 6553: 6504: 6457: 6445: 6441: 6410: 6361: 6321: 6309: 6218: 6180: 6166: 6128: 6114: 6076: 6027: 5984: 5940: 5891: 5848: 5805: 5769: 5726: 5691: 5648: 5613: 5556: 5521: 5486: 5436: 5368: 5327: 5268: 5217: 5160: 5111: 5076: 5041: 5000: 4946: 4902: 4850: 4799: 4778:"Intensive lipid lowering with atorvastatin in patients with stable coronary disease" 4751: 4702: 4642: 4598: 4557: 4508: 4465: 4422: 4418: 4355: 4283: 4234: 4185: 4136: 4105:

März W, Genser B, Drechsler C, Krane V, Grammer TB, Ritz E, et al. (June 2011).

4087: 4038: 3997: 3948: 3913: 3872: 3837: 3801: 3765: 3726: 3691: 3634: 3598: 3547: 3470: 3415: 3372: 3328: 3289: 3251: 3230:"Effect of Statins on Kidney Disease Outcomes: A Systematic Review and Meta-analysis" 3207: 3166: 3107: 3103: 3071: 3022: 2986: 2950: 2901: 2863: 2825: 2802: 2767: 2726: 2722: 2690: 2654: 2618: 2478: 2408: 2046: 1884: 1811: 1800: 1716: 1688: 1663: 1567: 1282: 1195: 1113: 949: 697: 381: 368: 151: 7829: 7042: 6373: 6039: 5996: 5860: 5817: 5660: 5568: 5172: 4610: 4520: 4477: 4367: 3646: 3427: 3119: 3034: 2540: 2233: 1814:

activity is approximately 30%. Atorvastatin undergoes high intestinal clearance and

8695: 7792: 7684: 7679: 7026: 7006: 6746: 6699: 6671: 6651: 6607: 6597: 6543: 6535: 6494: 6489: 6484: 6472: 6437: 6400: 6351: 6301: 6257: 6230: 6210: 6170: 6162: 6118: 6110: 6066: 6019: 5974: 5930: 5903: 5883: 5840: 5797: 5761: 5738: 5718: 5683: 5640: 5603: 5595: 5548: 5513: 5478: 5428: 5358: 5317: 5307: 5258: 5248: 5207: 5199: 5150: 5123: 5103: 5068: 5031: 4990: 4980: 4936: 4892: 4884: 4840: 4830: 4789: 4741: 4733: 4692: 4684: 4654: 4634: 4588: 4547: 4500: 4457: 4434: 4414: 4347: 4273: 4265: 4224: 4216: 4175: 4167: 4126: 4118: 4077: 4069: 4028: 3987: 3940: 3903: 3864: 3829: 3793: 3757: 3718: 3681: 3673: 3626: 3588: 3578: 3537: 3527: 3482: 3462: 3407: 3364: 3340: 3320: 3281: 3241: 3197: 3156: 3146: 3099: 3061: 3014: 2978: 2940: 2932: 2893: 2855: 2794: 2757: 2718: 2682: 2646: 2610: 2448: 2031: 1692:

cholesterol synthesis, increasing expression of low-density lipoprotein receptors (

1659: 1611: 1547: 1032: 781: 419: 323: 313: 303: 293: 283: 273: 263: 253: 243: 68: 6214: 5687: 4817:

Macedo AF, Taylor FC, Casas JP, Adler A, Prieto-Merino D, Ebrahim S (March 2014).

3974:

Wanner C, Krane V, März W, Olschewski M, Mann JF, Ruf G, et al. (July 2005).

3960: 3833: 3761: 3285: 2510: 1946:

and AUC. People with Child Pugh stage B liver disease show a 16-fold increase in C

546: 50: 8649: 8379: 8195: 6868: 6696:

The discovery and development of atorvastatin, a potent novel hypolipidemic agent

6405: 6388: 6305: 6262: 5979: 5962: 5107: 3797: 3324: 2650: 2084: 2055: 1888: 1866: 1807: 1307: 1246: 1120: 437: 427: 3976:"Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis" 3532: 3515: 8670: 8610: 8336: 8176: 5887: 5844: 5363: 5346: 5312: 5287: 5286:

Chu CS, Tseng PT, Stubbs B, Chen TY, Tang CH, Li DJ, et al. (April 2018).

4593: 4576: 4351: 3246: 3229: 2088: 2035: 2011: 1932: 1880: 1543: 1475: 1436: 1420: 1324: 1254: 1156: 933: 137: 7856: 7228: 5935: 5918: 5253: 5236: 5203: 4220: 3466: 3447: 3368: 3151: 3134: 2936: 1600:

supplementation lowers atorvastatin and active metabolite concentrations, yet

1419:

Fibrates are a class of drugs that can be used for severe or refractory mixed

8659: 7983: 7973: 6738: 5584:"Long-term safety of pravastatin-gemfibrozil therapy in mixed hyperlipidemia" 5552: 5413: 5386: 3722: 3411: 2798: 1939: 1872: 1573:

Some statins may also alter the concentrations of other medications, such as

1527: 1515: 1451: 1262: 1239: 757: 33: 5801: 5722: 4835: 4818: 4073: 4017:"Rosuvastatin and cardiovascular events in patients undergoing hemodialysis" 3186:"Effect of two intensive statin regimens on progression of coronary disease" 2982: 2686: 1201:

Liver impairment: Increased drug levels can be seen in people with advanced

8585: 8261: 8256: 8223: 8214: 8186: 8115: 8066: 8056: 8036: 7891: 7804: 6721: 6663: 6655: 6621: 6557: 6508: 6449: 6414: 6365: 6313: 6222: 6184: 6132: 6080: 6031: 5988: 5944: 5895: 5852: 5809: 5773: 5765: 5730: 5695: 5652: 5599: 5560: 5525: 5490: 5440: 5432: 5372: 5331: 5272: 5221: 5164: 5115: 5080: 5045: 5004: 4950: 4906: 4854: 4803: 4755: 4706: 4646: 4602: 4561: 4512: 4469: 4426: 4359: 4287: 4238: 4189: 4140: 4091: 4042: 4001: 3917: 3876: 3841: 3805: 3769: 3730: 3695: 3638: 3602: 3551: 3474: 3419: 3376: 3332: 3293: 3255: 3211: 3170: 3111: 3075: 3026: 2990: 2954: 2905: 2867: 2859: 2771: 2658: 2622: 1896: 1701: 1693: 1640:

A few cases of myopathy have been reported when atorvastatin is given with

1591: 1503: 1479: 1471: 1463: 1455: 1447: 1396: 1278: 1270: 1036: 1012: 988: 922: 318: 308: 298: 288: 278: 268: 258: 248: 238: 7018: 6758: 6698:. Progress in Medicinal Chemistry. Vol. 40. Elsevier. pp. 1–22. 6023: 5617: 5347:"Effects of Statins on Memory, Cognition, and Brain Volume in the Elderly" 4033: 4016: 3952: 3677: 3202: 3185: 2806: 2730: 2694: 586: 8565: 8540: 8520: 8489: 8397: 8369: 8364: 8359: 8354: 8349: 8301: 8296: 8286: 8281: 8246: 8153: 8143: 8071: 8061: 8041: 7991: 7958: 4985: 4941: 4924: 4794: 4777: 4122: 3992: 3975: 3908: 3891: 3583: 3566: 2897: 2474:

The Top 100 Drugs e-book: Clinical Pharmacology and Practical Prescribing

2100: 2092: 2051: 1995: 1876: 1683: 1605: 1511: 1467: 1428: 1424: 1216: 1024: 961: 145: 7563:"Pfizer Completes Transaction to Combine Its Upjohn Business with Mylan" 7360:"Atorvastatin Calcium (Lipitor Tablets) – Uses, Dosage and Side Effects" 6750: 6602: 6585: 6539: 6340:"Update on the efficacy of statin treatment in acute coronary syndromes" 2453: 2010:

The first synthesis of atorvastatin at Parke-Davis that occurred during

1887:

activity. The ortho-hydroxy metabolite undergoes further metabolism via

8580: 8555: 8535: 8530: 8525: 8434: 8407: 8402: 8392: 8306: 8276: 8271: 8266: 8200: 8148: 8110: 8051: 8046: 7968: 7963: 7926: 5155: 5138: 2762: 2745: 2108: 2080: 2023: 1953: 1862: 1766: in this section. Unsourced material may be challenged and removed. 1697: 1675: 1641: 1531: 1523: 1495: 1491: 1341: 1054: 817: 597: 6356: 6339: 5644: 5631:

Shek A, Ferrill MJ (July 2001). "Statin-fibrate combination therapy".

5517: 5482: 4922: 4625:

Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial".

3066: 3049: 2707: 8291: 7978: 7931: 7921: 7713:"Ranbaxy Recalls More Than 64,000 Bottles of Generic Lipitor in U.S." 6071: 6054: 5414:"Lipid-modifying therapies and risk of pancreatitis: a meta-analysis" 4461: 4252:

Chang JC, Chen YJ, Chen IC, Lin WS, Chen YM, Lin CH (December 2021).

4058:"Statins and All-Cause Mortality in Patients Undergoing Hemodialysis" 1927: 1837:

of atorvastatin. Evening dose administration is known to reduce the C

1597: 1535: 1519: 1507: 1487: 1459: 1351: 1233: 1224: 1202: 1180:

Pediatric: Pharmacokinetic data is not available for this population.

941: 532: 472: 467: 131: 7117:. Crain's New York Business via Associated Press. 28 December 2011. 3228:

Su X, Zhang L, Lv J, Wang J, Hou W, Xie X, et al. (June 2016).

1741: 8575: 8570: 8550: 8322: 8095: 7987: 2161: 2058:, an inexpensive and easily sourced plant-derived natural product. 1834: 1574: 1570:

also is proved to increase the risk of myopathy or rhabdomyolysis.

1561: 1499: 1432: 1346: 1266: 1250: 1228: 937: 926: 863:

O=C(O)C(O)C(O)CCn2c(c(c(c2c1ccc(F)cc1)c3ccccc3)C(=O)Nc4ccccc4)C(C)C

646: 577: 173: 6389:"High-dose statins should only be used in atherosclerotic strokes" 5919:"Efficacy and safety of rosuvastatin in treatment of dyslipidemia" 4925:"High-dose atorvastatin after stroke or transient ischemic attack" 3662:"Effects of combination lipid therapy in type 2 diabetes mellitus" 1810:

of the medication is about 14%, but the systemic availability for

840: 713: 8417: 8233: 6291: 4870: 3003: 2192: 2177: 2096: 2069: 1911: 1908: 1829:(extent of absorption), although food does not affect the plasma 1601: 1578: 1553: 1356: 1274: 1160: 7783:

Maggon K (June 2005). "Best-selling human medicines 2002–2004".

6734: 5185: 5137:

Cui JY, Zhou RR, Han S, Wang TS, Wang LQ, Xie XH (August 2018).

4967:

Safitri N, Alaina MF, Pitaloka DA, Abdulah R (8 November 2021).

4014: 3309: 2541:"Atorvastatin Drug Usage Statistics, United States, 2013 - 2022" 2145:

Atorvastatin is relatively inexpensive. Under provisions of the

2106:

In 1994, the findings of a Merck-funded study were published in

8105: 8014: 7913: 7443:"Price to UK for 28 tablets from £3.25 (10mg) to £10.00 (80mg)" 6996: 6966:"Pfizer Gets Its Deal to Buy Warner-Lambert for $ 90.2 Billion" 4670: 3183: 3132: 2153:(USPSTF) recommendations. Some plans only cover other statins. 1869: 1653: 1634: 1443: 1361: 1127: 1109: 953: 914: 677: 446: 41: 6583: 6096: 5873: 5751: 1387:

statin therapy on cardiovascular and cerebrovascular disease.

104: 8005: 5093: 5058: 4719: 3708: 2671: 2470: 1915: 1286: 957: 945: 831: 657: 442: 7830:"The Birth of a Blockbuster: Lipitor's Route out of the Lab" 7043:"The Birth of a Blockbuster: Lipitor's Route out of the Lab" 6294:

The International Journal of Biochemistry & Cell Biology

5786: 4966: 3854: 2824:. Adelaide, S. Aust: Australian Medicines Handbook Pty Ltd. 730: 80: 7293:"SignatureValue Zero Cost Share Preventive Medications PDL" 6337: 6148: 5344: 5234: 4254:"Perinatal Outcomes After Statin Exposure During Pregnancy" 4153: 3889: 2967: 1919: 1155:

Statins (predominantly simvastatin) have been evaluated in

1119:

Myocardial infarction and stroke prevention in people with

637: 86: 71: 4330: 3446:

Ma WQ, Zhao Y, Wang Y, Han XQ, Zhu Y, Liu NF (June 2018).

2132:

Pfizer's patent on atorvastatin expired in November 2011.

7170: 5538: 3973: 3782: 2635: 2439: 987:

The primary uses of atorvastatin is for the treatment of

979:

million prescriptions filled for over 27 million people.

98: 6990: 5017: 4447: 4104: 3659: 3088: 3047: 2784: 1490:, and only rarely with other CYP3A4 inhibitors, such as 6915: 6913: 5711:

Clinical and Experimental Pharmacology & Physiology

5673: 5411: 4775: 4623: 4490: 3818: 2883: 2743: 1670:

compound. HMG-CoA reductase catalyzes the reduction of

969:

World Health Organization's List of Essential Medicines

6771: 6641: 6521: 6287: 6285: 4816: 4574: 4111:

Clinical Journal of the American Society of Nephrology

8633: 7738: 7033: 6522:

Canestaro WJ, Austin MA, Thummel KE (November 2014).

5960: 4203:

Kim RG, Loomba R, Prokop LJ, Singh S (October 2017).

4056:

Jung J, Bae GH, Kang M, Kim SW, Lee DH (March 2020).

3746: 3565:

Zhang J, Guo Y, Jin Q, Bian L, Lin P (October 2018).

2228: 2226: 1658:

As with other statins, atorvastatin is a competitive

1112:, major coronary events, ischaemic heart disease and 948:. Like all statins, atorvastatin works by inhibiting 92: 74: 7133: 6910: 6798:"Fig. 1. Chemical structure of Atorvastatin Calcium" 6200: 5830: 5754:

The Journal of Clinical Endocrinology and Metabolism

5387:"Atorvastatin: A medicine used to lower cholesterol" 4294: 4202: 3930: 3615: 2471:

Hitchings A, Lonsdale D, Burrage D, Baker E (2014).

101: 95: 83: 77: 7357: 6282: 2844: 2325:"Lipitor- atorvastatin calcium tablet, film coated" 565: 89: 7828: 7711: 7329:"Affordable Care Act Implementation FAQs - Set 12" 7041: 6861: 5285: 2787:Arteriosclerosis, Thrombosis, and Vascular Biology 2675:Arteriosclerosis, Thrombosis, and Vascular Biology 2599: 2372:"Atorvastatin Calcium Monograph for Professionals" 2223: 1666:. Unlike most others, however, it is a completely 1585:, resulting in a minor drug-drug interaction. The 1372: 4536:"Statins and risk of new-onset diabetes mellitus" 1686:biosynthesis. Inhibition of the enzyme decreases 8657: 6827: 6825: 6823: 6776:. John Wiley & Sons, Inc. pp. 113–125. 6579: 6577: 6575: 6573: 6571: 6569: 6567: 6470: 5956: 5954: 5468: 4918: 4916: 4866: 4864: 4251: 3305: 3303: 2319: 2317: 2315: 2313: 2311: 2309: 2307: 2305: 545: 7886: 7465: 7159: 6855: 6853: 6851: 6849: 6637: 6635: 6633: 6631: 6243: 5581: 5503: 4962: 4960: 4771: 4769: 4767: 4765: 4666: 4664: 4400: 4398: 4396: 4394: 4392: 3742: 3740: 3564: 2918: 2595: 2593: 2591: 2400: 2303: 2301: 2299: 2297: 2295: 2293: 2291: 2289: 2287: 2285: 520: 7613:"FDA Statement on Ranbaxy Atorvastatin Recall" 7109: 7107: 6922:"The Early History of Parke-Davis and Company" 6427: 6333: 6331: 5708: 5136: 4055: 3353: 2879: 2877: 2165:Pack and tablet of atorvastatin (Lipitor) 40mg 1926:. Atorvastatin has an approximate elimination 1914:excretion, with less than 2% recovered in the 1442:Co-administration of atorvastatin with one of 7872: 7744: 7607: 7605: 6893: 6891: 6820: 6689: 6687: 6685: 6683: 6681: 6564: 6196: 6194: 6144: 6142: 5951: 5351:Journal of the American College of Cardiology 5143:Journal of Clinical Pharmacy and Therapeutics 4913: 4861: 4581:Journal of the American College of Cardiology 4404: 3445: 3396: 3300: 3271: 3227: 3177: 2570:American Society of Health-System Pharmacists 2234:"Atorvastatin (Lipitor) Use During Pregnancy" 7641: 7384: 7197:"PPACA no cost-share preventive medications" 7068: 6959: 6957: 6846: 6628: 6380: 6092: 6090: 6003: 5910: 5867: 5824: 5780: 4957: 4762: 4661: 4617: 4533: 4389: 4324: 3737: 3392: 3390: 3388: 3386: 3267: 3265: 3082: 3041: 2997: 2737: 2588: 2282: 2151:United States Preventive Services Task Force 1378:advised in patients with Type 2 Diabetes. 177: 7267:United States Preventive Services Taskforce 7104: 6863:"The fall of the world's best-selling drug" 6471:Adams SP, Tsang M, Wright JM (March 2015). 6328: 5630: 5405: 3509: 3507: 3441: 3439: 3437: 3126: 2874: 2778: 2701: 2665: 2629: 2030:route to atorvastatin made use of an ester 1875:to form active ortho- and parahydroxylated 1825:(rate of absorption) and a 9% reduction in 7879: 7865: 7602: 7115:"Lipitor becomes world's top-selling drug" 6888: 6678: 6344:European Journal of Clinical Investigation 6191: 6139: 6052: 5923:American Journal of Health-System Pharmacy 3558: 3513: 3223: 3221: 2919:Law MR, Wald NJ, Rudnicka AR (June 2003). 2366: 2364: 2362: 2360: 2358: 2356: 2354: 2352: 2350: 2147:Patient Protection and Affordable Care Act 1407:Statins seem to have a positive effect on 1051:Heterozygous familial hypercholesterolemia 767: 744: 605: 8546:Magnesium pyridoxal 5-phosphate glutamate 6954: 6611: 6601: 6547: 6498: 6488: 6404: 6355: 6261: 6174: 6122: 6087: 6070: 5978: 5934: 5607: 5362: 5321: 5311: 5262: 5252: 5211: 5154: 5035: 4994: 4984: 4940: 4896: 4844: 4834: 4793: 4745: 4696: 4592: 4551: 4277: 4228: 4179: 4130: 4081: 4062:Journal of the American Heart Association 4032: 3991: 3907: 3711:European Journal of Preventive Cardiology 3685: 3592: 3582: 3541: 3531: 3383: 3262: 3245: 3201: 3160: 3150: 3065: 2944: 2761: 2750:Journal of Atherosclerosis and Thrombosis 2477:. Elsevier Health Sciences. p. 197. 2466: 2464: 2452: 1907:Atorvastatin is primarily eliminated via 1782:Learn how and when to remove this message 1269:is increased by the co-administration of 1084: 625: 7378: 6963: 6155:British Journal of Clinical Pharmacology 6103:British Journal of Clinical Pharmacology 6046: 6009: 5916: 5582:Iliadis EA, Rosenson RS (January 1999). 4209:Clinical Gastroenterology and Hepatology 3504: 3434: 2813: 2160: 2125:billion in sales over approximately 14.5 2001: 1989: 1257:, and it may be very serious leading to 1060:Homozygous familial hypercholesterolemia 7826: 7675:"Ranbaxy recalls generic Lipitor doses" 7672: 7644:"Ranbaxy Recalls Generic Lipitor Doses" 7642:Loftus P, Weaver C (23 November 2012). 7039: 6897: 6477:Cochrane Database of Systematic Reviews 3869:10.7326/0003-4819-147-1-200707030-00002 3218: 2347: 2195:after Upjohn was spun off from Pfizer. 1402: 1170: 740: 585: 150: 14: 8658: 7811: 7782: 7709: 7534: 7147:from the original on 17 September 2021 7092:from the original on 24 September 2020 6942:from the original on 20 September 2018 6919: 6859: 6831: 6244:McLachlan A, Ramzan I (1 April 2006). 6203:Clinical Pharmacology and Therapeutics 6012:Clinical Pharmacology and Therapeutics 5876:Clinical Pharmacology and Therapeutics 5833:Clinical Pharmacology and Therapeutics 5790:Clinical Pharmacology and Therapeutics 4340:Clinical Pharmacology and Therapeutics 2461: 2433: 2407:. John Wiley & Sons. p. 473. 2394: 2268:Therapeutic Goods Administration (TGA) 2135: 1647: 1126:A 2014 meta-analysis showed high-dose 758: 387: 362: 7860: 7759:from the original on 29 December 2017 7691:from the original on 29 December 2017 7539:. PharmacyToday.co.nz. Archived from 7537:"Atorvastatin sole funding announced" 7121:from the original on 29 December 2011 6978:from the original on 15 December 2018 6876:from the original on 10 December 2022 6386: 6053:Kane GC, Lipsky JJ (September 2000). 4534:Shah RV, Goldfine AB (October 2012). 4377:from the original on 26 February 2023 4308:. U.S. National Library of Medicine. 4245: 3896:Nephrology, Dialysis, Transplantation 3514:Cho A, Lee YK, Sohn SY (March 2020). 3492:from the original on 30 November 2020 2819: 2491:from the original on 26 February 2023 2447:. Geneva: World Health Organization. 2335:from the original on 26 November 2020 2203:On 9 November 2012, Indian drugmaker 2198: 1985: 1672:3-hydroxy-3-methylglutaryl-coenzyme A 1009:heterozygous familial and nonfamilial 706: 685: 665: 375: 168: 136: 7745:Siddiqui Z, Sikka K (8 March 2014). 7516:from the original on 20 October 2020 7351: 7309:from the original on 5 February 2022 7209:from the original on 2 December 2020 7177:from the original on 18 January 2017 7167:"Lipitor loses patent, goes generic" 6693: 6055:"Drug-grapefruit juice interactions" 5450:from the original on 23 January 2022 5393:from the original on 7 November 2021 5241:Journal of General Internal Medicine 4450:Pharmacoepidemiology and Drug Safety 3571:Drug Design, Development and Therapy 3455:International Urology and Nephrology 2576:from the original on 25 October 2010 2558: 2421:from the original on 12 January 2023 2382:from the original on 25 October 2010 2244:from the original on 4 December 2019 2068:involves two atorvastatin ions, one 1764:adding citations to reliable sources 1735: 1209: 712: 322: 312: 302: 292: 282: 272: 262: 252: 242: 6808:from the original on 21 August 2022 6270:from the original on 27 August 2021 4973:Drug, Healthcare and Patient Safety 4929:The New England Journal of Medicine 4782:The New England Journal of Medicine 4021:The New England Journal of Medicine 3980:The New England Journal of Medicine 3666:The New England Journal of Medicine 3234:American Journal of Kidney Diseases 3190:The New England Journal of Medicine 2886:The New England Journal of Medicine 2521:from the original on 30 August 2024 1968: 1731: 1722: 921:in those at high risk and to treat 645: 536: 24: 7775: 7623:from the original on 19 April 2014 7483:from the original on 3 August 2020 7423:from the original on 12 April 2020 7413:"Pfizer's 180-Day War for Lipitor" 7243:from the original on 3 August 2020 7143:. Ann Arbor Observer. April 2020. 6473:"Atorvastatin for lowering lipids" 5676:The American Journal of Cardiology 4270:10.1001/jamanetworkopen.2021.41321 3945:10.1002/j.1552-4604.1997.tb05629.x 3822:The American Journal of Cardiology 3750:The American Journal of Cardiology 3274:The American Journal of Cardiology 3092:Diabetes, Obesity & Metabolism 2822:Australian medicines handbook 2006 2191:In the US, Lipitor is marketed by 1895:with concurrent administration of 25: 8712: 7910:Cholesterol absorption inhibitors 7843:from the original on 7 April 2019 7726:from the original on 21 June 2019 7141:"The Vindication of Roger Newton" 7056:from the original on 7 April 2019 5096:Journal of Investigative Medicine 5037:10.1161/CIRCULATIONAHA.106.624890 4553:10.1161/CIRCULATIONAHA.112.122135 4312:from the original on 12 June 2018 1704:and slightly increases levels of 1150: 1137: 349: 200: 8643: 7703: 7666: 7654:from the original on 17 May 2021 7635: 7577: 7555: 7528: 7495: 7435: 7405: 7321: 7285: 7255: 7221: 7189: 6790: 6765: 6728: 6515: 6442:10.2165/00003495-200767001-00006 6167:10.1111/j.1365-2125.2011.03996.x 6115:10.1111/j.1365-2125.2005.02462.x 4419:10.2165/00003088-200241050-00003 3933:Journal of Clinical Pharmacology 3104:10.1046/j.1463-1326.2000.00106.x 2723:10.1001/jama.1996.03530260042029 1950:and an 11-fold increase in AUC. 1740: 1071:Primary dysbetalipoproteinemia ( 801: 798: 792: 503:)-7--3,5-dihydroxyheptanoic acid 67: 49: 40: 7673:Johnson LA (24 November 2012). 7339:from the original on 5 May 2022 7273:from the original on 9 May 2022 6464: 6421: 6237: 5745: 5702: 5667: 5624: 5575: 5532: 5497: 5462: 5379: 5338: 5279: 5228: 5179: 5130: 5087: 5052: 5011: 4810: 4713: 4568: 4527: 4484: 4441: 4196: 4147: 4098: 4049: 4008: 3967: 3924: 3883: 3848: 3812: 3776: 3702: 3653: 3609: 3347: 2961: 2912: 2838: 2401:Fischer J, Ganellin CR (2006). 2072:ion and three water molecules. 1844: 1751:needs additional citations for 1414: 1390: 1373:Increased fasting blood glucose 1296: 998: 982: 960:that plays a role in producing 888:Key:XUKUURHRXDUEBC-KAYWLYCHSA-N 27:Cholesterol-lowering medication 6964:Petersen M (8 February 2000). 6490:10.1002/14651858.cd008226.pub3 5506:The Journal of Sexual Medicine 5471:The Journal of Sexual Medicine 5061:American Journal of Cardiology 4499:(9716). Elsevier BV: 735–742. 2533: 2503: 2256: 2156: 807: 786: 13: 1: 7827:Winslow R (24 January 2000). 7797:10.1016/S1359-6446(05)03468-9 7040:Winslow R (24 January 2000). 7011:10.1016/s0140-6736(94)90566-5 6860:Andrew J (28 November 2009). 6704:10.1016/S0079-6468(08)70080-8 6215:10.1053/cp.1999.v66.100453001 5688:10.1016/j.amjcard.2010.07.041 5633:The Annals of Pharmacotherapy 5073:10.1016/S0002-9149(03)00820-8 4889:10.1016/S0140-6736(10)60310-8 4738:10.1016/s0140-6736(22)01545-8 4689:10.1016/S0140-6736(10)61350-5 4639:10.1016/S0140-6736(03)12948-0 4505:10.1016/s0140-6736(09)61965-6 4172:10.1016/S0140-6736(11)60739-3 3834:10.1016/j.amjcard.2006.09.111 3762:10.1016/j.amjcard.2005.07.107 3631:10.1016/S0140-6736(05)67667-2 3357:Heart, Lung & Circulation 3286:10.1016/j.amjcard.2014.05.033 3019:10.1016/S0140-6736(04)16895-5 2615:10.1016/S0022-3476(03)00186-0 2404:Analogue-based Drug Discovery 2216: 1856: 1794: 7812:Simons J (20 January 2003). 7617:Food and Drug Administration 7473:"Atorvastatin international" 7387:"Lipitor – What is Lipitor?" 7083:Food and Drug Administration 6832:Simons J (20 January 2003). 6406:10.1161/STROKEAHA.111.633339 6306:10.1016/j.biocel.2020.105735 6263:10.18773/austprescr.2006.026 5980:10.1161/CIR.0000000000000456 5108:10.2310/JIM.0b013e318197ec8b 3798:10.1097/hjh.0b013e328342c8f7 3325:10.1161/STROKEAHA.114.005832 2651:10.1001/jama.295.13.jpc60002 2140: 1924:entero-hepatic recirculation 1902: 1381: 1323:define the requirement that 7: 7449:. June 2012. Archived from 7385:News Medical (March 2010). 6774:Contemporary Drug Synthesis 3857:Annals of Internal Medicine 3533:10.1097/MD.0000000000019473 1431:) may increase the risk of 917:medication used to prevent 10: 8717: 7573:– via Business Wire. 7565:. Pfizer. 16 November 2020 5888:10.1016/j.clpt.2005.04.007 5845:10.1016/j.clpt.2006.09.003 5364:10.1016/j.jacc.2019.09.041 5313:10.1038/s41598-018-24248-8 4594:10.1016/j.jacc.2010.10.047 4352:10.1016/j.clpt.2006.02.014 3247:10.1053/j.ajkd.2016.01.016 2457:. WHO/MHP/HPS/EML/2023.02. 2075: 2041:Once the compound entered 1651: 1587:American Heart Association 1583:area under the curve (AUC) 776:Chemical and physical data 8686:Drugs developed by Pfizer 8594: 8561:Omega−3-acid ethyl esters 8508: 8447: 8416: 8378: 8335: 8315: 8232: 8222: 8213: 8185: 8162: 8129: 8080: 8013: 8004: 7940: 7908: 7899: 7710:Loftus P (7 March 2014). 7619:(FDA). 30 December 2012. 7508:European Medicines Agency 7358:Medical Product Reviews. 7233:American Family Physician 6590:Journal of Lipid Research 5254:10.1007/s11606-014-3115-3 5204:10.1007/s00125-015-3802-6 4407:Clinical Pharmacokinetics 4221:10.1016/j.cgh.2017.04.039 3467:10.1007/s11255-018-1814-0 3369:10.1016/j.hlc.2016.11.024 3152:10.1186/s12916-015-0459-4 2937:10.1136/bmj.326.7404.1423 2603:The Journal of Pediatrics 2441:World Health Organization 2050:atorvastatin relied on a 1806:) of 1–2 h. The absolute 1542:increased AUC values for 1332: 896: 871: 851: 829: 816: 780: 775: 756: 724: 696: 676: 656: 636: 616: 596: 576: 556: 531: 511: 483: 478: 466: 453: 436: 426: 418: 399:European Medicines Agency 339: 334: 229: 215: 188: 158: 144: 126: 116: 62: 57: 48: 39: 8676:4-Fluorophenyl compounds 8460:Bempedoic acid/ezetimibe 8081:Niacin and derivatives ( 7535:Rapley L (31 May 2012). 6644:Pharmacogenomics Journal 5917:McKenney JM (May 2005). 5553:10.1001/jama.292.21.2585 4456:(10). Wiley: 1131–1149. 3412:10.1177/0003319718801246 2799:10.1161/01.ATV.17.8.1527 2043:pre-clinical development 1367: 1301: 1104:of all-cause mortality, 8485:Fenofibrate/simvastatin 8480:Fenofibrate/pravastatin 8455:Amlodipine/atorvastatin 7836:The Wall Street Journal 7719:The Wall Street Journal 7648:The Wall Street Journal 7447:National Health Service 7049:The Wall Street Journal 6059:Mayo Clinic Proceedings 5936:10.1093/ajhp/62.10.1033 5802:10.1067/mcp.2000.110537 5723:10.1111/1440-1681.12053 4836:10.1186/1741-7015-12-51 4074:10.1161/JAHA.119.014840 3786:Journal of Hypertension 2983:10.1001/jama.291.9.1071 2687:10.1161/01.ATV.15.5.678 2171:atorvastatin/amlodipine 2095:lovastatin (brand name 1719:recurrence prevention. 1713:acute coronary syndrome 1275:fibric acid derivatives 1132:acute coronary syndrome 1096:coronary artery disease 1079:Combined hyperlipidemia 971:. It is available as a 8470:Ezetimibe/rosuvastatin 8465:Ezetimibe/atorvastatin 7942:Bile acid sequestrants 7239:(2). 15 January 2017. 6656:10.1038/sj.tpj.6500328 6387:Furie KL (July 2012). 5766:10.1210/jc.2003-030153 5600:10.1002/clc.4960220110 5433:10.1001/jama.2012.8439 3723:10.1093/eurjpc/zwac085 2566:"Atorvastatin Calcium" 2178:Watson Pharmaceuticals 2166: 2020:chiral chromatographic 2007: 1999: 1851:volume of distribution 1627:cardiovascular disease 1604:reduces LDL and total 1221:hepatic encephalopathy 1215:Active liver disease: 1085:Cardiovascular disease 1064:Hypertriglyceridemia ( 993:cardiovascular disease 991:and the prevention of 936:, liver problems, and 919:cardiovascular disease 8475:Ezetimibe/simvastatin 7888:Lipid-lowering agents 7512:. 17 September 2018. 6899:US patent 4681893 6250:Australian Prescriber 6246:"Meals and medicines" 6024:10.1038/clpt.2008.165 4034:10.1056/NEJMoa0810177 3678:10.1056/NEJMoa1001282 3203:10.1056/NEJMoa1110874 2820:Rossi S, ed. (2006). 2511:"The Top 300 of 2022" 2164: 2005: 1993: 1940:hepatic insufficiency 1879:, as well as various 1865:is primarily through 1816:first-pass metabolism 1106:myocardial infarction 1017:Fredrickson types IIa 923:abnormal lipid levels 8516:Alipogene tiparvovec 8242:Aluminium clofibrate 8101:Aluminium nicotinate 7785:Drug Discovery Today 7453:on 20 September 2012 7269:. 15 November 2016. 7173:. 30 November 2011. 6528:Genetics in Medicine 4986:10.2147/DHPS.S333738 4942:10.1056/NEJMoa061894 4795:10.1056/NEJMoa050461 4215:(10): 1521–1530.e8. 4123:10.2215/CJN.09121010 3993:10.1056/NEJMoa043545 3584:10.2147/DDDT.S178020 2898:10.1056/NEJMoa050461 2860:10.1093/qjmed/hcq165 2205:Ranbaxy Laboratories 2182:Ranbaxy Laboratories 2063:atorvastatin calcium 1760:improve this article 1623:area under the curve 1409:erectile dysfunction 1403:Erectile dysfunction 1171:Specific populations 1159:in combination with 1102:Secondary prevention 1073:Fredrickson Type III 1043:as well as increase 1005:Hypercholesterolemia 8681:Isopropyl compounds 8252:Choline fenofibrate 7752:The Washington Post 6751:10.1021/jm00105a056 6603:10.1194/jlr.P021113 6540:10.1038/gim.2014.41 5588:Clinical Cardiology 5304:2018NatSR...8.5804C 4883:(9753): 1658–1669. 4683:(9753): 1670–1681. 3625:(9500): 1849–1861. 2240:. 3 February 2020. 2136:Society and culture 1648:Mechanism of action 1540:Oral contraceptives 1484:protease inhibitors 1446:inhibitors such as 1259:acute kidney injury 1066:Fredrickson Type IV 401:. 17 September 2018 371:(Prescription only) 358:(Prescription only) 36: 8621:Never to phase III 8500:Niacin/simvastatin 8490:Niacin/laropiprant 7503:"Lipitor referral" 7302:. September 2021. 6971:The New York Times 6920:Hoefle ML (2000). 5389:. 3 January 2019. 5292:Scientific Reports 5156:10.1111/jcpt.12690 4732:(10355): 832–845. 4306:toxnet.nlm.nih.gov 3909:10.1093/ndt/gfg048 2763:10.5551/jat.13.216 2199:Medication recalls 2167: 2022:separation of the 2008: 2000: 1986:Chemical synthesis 1680:rate-limiting step 1245:Markedly elevated 1091:Primary prevention 1023:) to reduce total 973:generic medication 32: 8631: 8630: 8495:Niacin/lovastatin 8443: 8442: 8331: 8330: 8209: 8208: 8164:ATP citrate lyase 8121:Nicotinyl alcohol 8019:HMG-CoA reductase 8000: 7999: 7419:. 8 August 2013. 7366:on 6 October 2013 7335:. 22 April 2013. 7076:"Approval Letter" 6783:978-0-471-21480-9 6713:978-0-444-51054-9 6357:10.1111/eci.12255 5973:(21): e468–e495. 5682:(11): 1594–1601. 5645:10.1345/aph.10315 5547:(21): 2585–2590. 5518:10.1111/jsm.12497 5483:10.1111/jsm.12521 5357:(21): 2554–2568. 4788:(14): 1425–1435. 4633:(9364): 1149–58. 4587:(14): 1535–1545. 4546:(18): e282–e284. 4258:JAMA Network Open 4166:(9784): 2181–92. 3717:(14): e319–e322. 3672:(17): 1563–1574. 3363:(11): 1200–1207. 3319:(10): 2974–2982. 3067:10.2337/dc06-0872 2892:(14): 1425–1435. 2831:978-0-9757919-2-9 2484:978-0-7020-5515-7 2087:version of rival 2047:process chemistry 1885:HMG-CoA reductase 1812:HMG-CoA reductase 1792: 1791: 1784: 1717:thrombotic stroke 1664:HMG-CoA reductase 1210:Contraindications 1196:post hoc analysis 1114:revascularization 950:HMG-CoA reductase 908: 907: 842:Interactive image 726:CompTox Dashboard 391: 379: 366: 353: 204: 171: 16:(Redirected from 8708: 8648: 8647: 8646: 8639: 8380:PCSK9 inhibitors 8230: 8229: 8220: 8219: 8011: 8010: 7906: 7905: 7881: 7874: 7867: 7858: 7857: 7852: 7850: 7848: 7832: 7823: 7808: 7769: 7768: 7766: 7764: 7742: 7736: 7735: 7733: 7731: 7715: 7707: 7701: 7700: 7698: 7696: 7685:Associated Press 7680:The Boston Globe 7670: 7664: 7663: 7661: 7659: 7639: 7633: 7632: 7630: 7628: 7609: 7600: 7599: 7597: 7595: 7581: 7575: 7574: 7572: 7570: 7559: 7553: 7552: 7550: 7548: 7532: 7526: 7525: 7523: 7521: 7499: 7493: 7492: 7490: 7488: 7469: 7463: 7462: 7460: 7458: 7439: 7433: 7432: 7430: 7428: 7409: 7403: 7402: 7400: 7398: 7389:. Archived from 7382: 7376: 7375: 7373: 7371: 7362:. Archived from 7355: 7349: 7348: 7346: 7344: 7325: 7319: 7318: 7316: 7314: 7308: 7297: 7289: 7283: 7282: 7280: 7278: 7259: 7253: 7252: 7250: 7248: 7225: 7219: 7218: 7216: 7214: 7208: 7201: 7193: 7187: 7186: 7184: 7182: 7163: 7157: 7156: 7154: 7152: 7137: 7131: 7130: 7128: 7126: 7111: 7102: 7101: 7099: 7097: 7091: 7080: 7072: 7066: 7065: 7063: 7061: 7045: 7037: 7031: 7030: 7005:(8934): 1383–9. 6994: 6988: 6987: 6985: 6983: 6961: 6952: 6951: 6949: 6947: 6941: 6929:Bull. Hist. Chem 6926: 6917: 6908: 6907: 6906: 6902: 6895: 6886: 6885: 6883: 6881: 6865: 6857: 6844: 6843: 6829: 6818: 6817: 6815: 6813: 6802:Researchgate.net 6794: 6788: 6787: 6769: 6763: 6762: 6732: 6726: 6725: 6691: 6676: 6675: 6639: 6626: 6625: 6615: 6605: 6581: 6562: 6561: 6551: 6519: 6513: 6512: 6502: 6492: 6468: 6462: 6461: 6425: 6419: 6418: 6408: 6399:(7): 1994–1995. 6384: 6378: 6377: 6359: 6335: 6326: 6325: 6289: 6280: 6279: 6277: 6275: 6265: 6241: 6235: 6234: 6198: 6189: 6188: 6178: 6146: 6137: 6136: 6126: 6094: 6085: 6084: 6074: 6072:10.4065/75.9.933 6050: 6044: 6043: 6007: 6001: 6000: 5982: 5958: 5949: 5948: 5938: 5914: 5908: 5907: 5871: 5865: 5864: 5828: 5822: 5821: 5784: 5778: 5777: 5760:(7): 3212–3217. 5749: 5743: 5742: 5706: 5700: 5699: 5671: 5665: 5664: 5639:(7–8): 908–917. 5628: 5622: 5621: 5611: 5579: 5573: 5572: 5536: 5530: 5529: 5501: 5495: 5494: 5466: 5460: 5459: 5457: 5455: 5449: 5418: 5409: 5403: 5402: 5400: 5398: 5383: 5377: 5376: 5366: 5342: 5336: 5335: 5325: 5315: 5283: 5277: 5276: 5266: 5256: 5232: 5226: 5225: 5215: 5183: 5177: 5176: 5158: 5134: 5128: 5127: 5091: 5085: 5084: 5056: 5050: 5049: 5039: 5015: 5009: 5008: 4998: 4988: 4964: 4955: 4954: 4944: 4920: 4911: 4910: 4900: 4868: 4859: 4858: 4848: 4838: 4814: 4808: 4807: 4797: 4773: 4760: 4759: 4749: 4717: 4711: 4710: 4700: 4668: 4659: 4658: 4621: 4615: 4614: 4596: 4572: 4566: 4565: 4555: 4531: 4525: 4524: 4488: 4482: 4481: 4462:10.1002/pds.4020 4445: 4439: 4438: 4402: 4387: 4386: 4384: 4382: 4376: 4337: 4328: 4322: 4321: 4319: 4317: 4298: 4292: 4291: 4281: 4264:(12): e2141321. 4249: 4243: 4242: 4232: 4200: 4194: 4193: 4183: 4151: 4145: 4144: 4134: 4102: 4096: 4095: 4085: 4053: 4047: 4046: 4036: 4027:(14): 1395–407. 4012: 4006: 4005: 3995: 3971: 3965: 3964: 3928: 3922: 3921: 3911: 3887: 3881: 3880: 3852: 3846: 3845: 3816: 3810: 3809: 3780: 3774: 3773: 3744: 3735: 3734: 3706: 3700: 3699: 3689: 3657: 3651: 3650: 3613: 3607: 3606: 3596: 3586: 3562: 3556: 3555: 3545: 3535: 3511: 3502: 3501: 3499: 3497: 3491: 3461:(6): 1085–1095. 3452: 3443: 3432: 3431: 3394: 3381: 3380: 3351: 3345: 3344: 3307: 3298: 3297: 3269: 3260: 3259: 3249: 3225: 3216: 3215: 3205: 3181: 3175: 3174: 3164: 3154: 3130: 3124: 3123: 3086: 3080: 3079: 3069: 3045: 3039: 3038: 3013:(9435): 685–96. 3001: 2995: 2994: 2977:(9): 1071–1080. 2965: 2959: 2958: 2948: 2931:(7404): 1423–0. 2916: 2910: 2909: 2881: 2872: 2871: 2842: 2836: 2835: 2817: 2811: 2810: 2782: 2776: 2775: 2765: 2741: 2735: 2734: 2705: 2699: 2698: 2669: 2663: 2662: 2633: 2627: 2626: 2597: 2586: 2585: 2583: 2581: 2562: 2556: 2555: 2553: 2551: 2537: 2531: 2530: 2528: 2526: 2507: 2501: 2500: 2498: 2496: 2468: 2459: 2458: 2456: 2437: 2431: 2430: 2428: 2426: 2398: 2392: 2391: 2389: 2387: 2368: 2345: 2344: 2342: 2340: 2321: 2280: 2279: 2277: 2275: 2260: 2254: 2253: 2251: 2249: 2230: 2211: 2128: 2124: 2119: 2056:isoascorbic acid 2032:chiral auxiliary 2028:enantioselective 1973:Several genetic 1969:Pharmacogenetics 1959: 1787: 1780: 1776: 1773: 1767: 1744: 1736: 1732:Pharmacokinetics 1723:Pharmacodynamics 1635:ischaemic stroke 1612:Grapefruit juice 1608:concentrations. 1548:ethinylestradiol 1325:hepatic function 1194:However, data ( 978: 904: 903: 844: 824: 809: 803: 800: 794: 788: 771: 760: 749: 748: 734: 732: 716: 710: 689: 669: 649: 629: 609: 589: 569: 549: 539: 538: 524: 458: 410: 408: 406: 389: 386: 377: 374: 364: 361: 351: 348: 326: 316: 306: 296: 286: 276: 266: 256: 246: 202: 199: 181: 170: 167: 154: 140: 111: 110: 107: 106: 103: 100: 97: 94: 91: 88: 85: 82: 79: 76: 73: 53: 44: 37: 35: 31: 21: 8716: 8715: 8711: 8710: 8709: 8707: 8706: 8705: 8656: 8655: 8654: 8644: 8642: 8634: 8632: 8627: 8626: 8611:Clinical trials 8590: 8504: 8439: 8412: 8374: 8337:CETP inhibitors 8327: 8311: 8205: 8196:Dextrothyroxine 8181: 8158: 8125: 8076: 7996: 7936: 7895: 7885: 7855: 7846: 7844: 7778: 7776:Further reading 7773: 7772: 7762: 7760: 7743: 7739: 7729: 7727: 7708: 7704: 7694: 7692: 7671: 7667: 7657: 7655: 7640: 7636: 7626: 7624: 7611: 7610: 7603: 7593: 7591: 7583: 7582: 7578: 7568: 7566: 7561: 7560: 7556: 7546: 7544: 7543:on 17 July 2014 7533: 7529: 7519: 7517: 7501: 7500: 7496: 7486: 7484: 7471: 7470: 7466: 7456: 7454: 7441: 7440: 7436: 7426: 7424: 7411: 7410: 7406: 7396: 7394: 7393:on 8 March 2012 7383: 7379: 7369: 7367: 7356: 7352: 7342: 7340: 7327: 7326: 7322: 7312: 7310: 7306: 7295: 7291: 7290: 7286: 7276: 7274: 7261: 7260: 7256: 7246: 7244: 7227: 7226: 7222: 7212: 7210: 7206: 7199: 7195: 7194: 7190: 7180: 7178: 7165: 7164: 7160: 7150: 7148: 7139: 7138: 7134: 7124: 7122: 7113: 7112: 7105: 7095: 7093: 7089: 7078: 7074: 7073: 7069: 7059: 7057: 7038: 7034: 6995: 6991: 6981: 6979: 6962: 6955: 6945: 6943: 6939: 6924: 6918: 6911: 6904: 6896: 6889: 6879: 6877: 6869:Financial Times 6858: 6847: 6830: 6821: 6811: 6809: 6796: 6795: 6791: 6784: 6770: 6766: 6733: 6729: 6714: 6692: 6679: 6640: 6629: 6582: 6565: 6534:(11): 810–819. 6520: 6516: 6483:(3): CD008226. 6469: 6465: 6426: 6422: 6385: 6381: 6336: 6329: 6290: 6283: 6273: 6271: 6242: 6238: 6199: 6192: 6147: 6140: 6095: 6088: 6051: 6047: 6008: 6004: 5959: 5952: 5929:(10): 1033–47. 5915: 5911: 5872: 5868: 5829: 5825: 5785: 5781: 5750: 5746: 5707: 5703: 5672: 5668: 5629: 5625: 5580: 5576: 5537: 5533: 5502: 5498: 5467: 5463: 5453: 5451: 5447: 5416: 5410: 5406: 5396: 5394: 5385: 5384: 5380: 5343: 5339: 5284: 5280: 5233: 5229: 5184: 5180: 5135: 5131: 5092: 5088: 5057: 5053: 5030:(25): 2788–97. 5016: 5012: 4965: 4958: 4921: 4914: 4869: 4862: 4815: 4811: 4774: 4763: 4718: 4714: 4669: 4662: 4622: 4618: 4573: 4569: 4532: 4528: 4489: 4485: 4446: 4442: 4403: 4390: 4380: 4378: 4374: 4335: 4329: 4325: 4315: 4313: 4300: 4299: 4295: 4250: 4246: 4201: 4197: 4152: 4148: 4103: 4099: 4054: 4050: 4013: 4009: 3972: 3968: 3929: 3925: 3888: 3884: 3853: 3849: 3817: 3813: 3781: 3777: 3745: 3738: 3707: 3703: 3658: 3654: 3614: 3610: 3563: 3559: 3512: 3505: 3495: 3493: 3489: 3450: 3444: 3435: 3395: 3384: 3352: 3348: 3308: 3301: 3270: 3263: 3226: 3219: 3196:(22): 2078–87. 3182: 3178: 3131: 3127: 3087: 3083: 3060:(11): 2378–84. 3046: 3042: 3002: 2998: 2966: 2962: 2917: 2913: 2882: 2875: 2843: 2839: 2832: 2818: 2814: 2783: 2779: 2742: 2738: 2706: 2702: 2670: 2666: 2645:(13): 1556–65. 2634: 2630: 2598: 2589: 2579: 2577: 2564: 2563: 2559: 2549: 2547: 2539: 2538: 2534: 2524: 2522: 2509: 2508: 2504: 2494: 2492: 2485: 2469: 2462: 2438: 2434: 2424: 2422: 2415: 2399: 2395: 2385: 2383: 2370: 2369: 2348: 2338: 2336: 2323: 2322: 2283: 2273: 2271: 2262: 2261: 2257: 2247: 2245: 2232: 2231: 2224: 2219: 2209: 2201: 2159: 2143: 2138: 2126: 2122: 2117: 2089:Merck & Co. 2078: 1988: 1971: 1963: 1957: 1949: 1945: 1905: 1889:glucuronidation 1867:cytochrome P450 1859: 1847: 1840: 1823: 1808:bioavailability 1804: 1797: 1788: 1777: 1771: 1768: 1757: 1745: 1734: 1725: 1711:In people with 1706:HDL-cholesterol 1678:, which is the 1656: 1650: 1619: 1602:synergistically 1421:hyperlipidaemia 1417: 1405: 1393: 1384: 1375: 1370: 1335: 1308:Type 2 diabetes 1304: 1299: 1249:levels or if a 1212: 1173: 1157:clinical trials 1153: 1140: 1121:type 2 diabetes 1087: 1001: 985: 976: 899: 897: 892: 889: 884: 879: 878: 867: 864: 859: 858: 847: 822: 812: 806: 797: 791: 752: 728: 720: 692: 672: 652: 632: 612: 592: 572: 552: 535: 527: 507: 504: 491: 490: 456: 428:Bioavailability 420:Pharmacokinetic 414: 404: 402: 393: 330: 218: 211: 208:Contraindicated 191: 184: 122:Lipitor, others 70: 66: 28: 23: 22: 15: 12: 11: 5: 8714: 8704: 8703: 8698: 8693: 8688: 8683: 8678: 8673: 8668: 8653: 8652: 8629: 8628: 8625: 8624: 8623: 8622: 8619: 8608: 8602: 8596: 8595: 8592: 8591: 8589: 8588: 8583: 8578: 8573: 8568: 8563: 8558: 8553: 8548: 8543: 8538: 8533: 8528: 8523: 8518: 8512: 8510: 8506: 8505: 8503: 8502: 8497: 8492: 8487: 8482: 8477: 8472: 8467: 8462: 8457: 8451: 8449: 8445: 8444: 8441: 8440: 8438: 8437: 8431: 8429: 8414: 8413: 8411: 8410: 8405: 8400: 8395: 8389: 8387: 8376: 8375: 8373: 8372: 8367: 8362: 8357: 8352: 8346: 8344: 8333: 8332: 8329: 8328: 8326: 8325: 8319: 8317: 8313: 8312: 8310: 8309: 8304: 8299: 8294: 8289: 8284: 8279: 8274: 8269: 8264: 8259: 8254: 8249: 8244: 8238: 8236: 8227: 8217: 8211: 8210: 8207: 8206: 8204: 8203: 8198: 8192: 8190: 8183: 8182: 8180: 8179: 8177:Bempedoic acid 8173: 8171: 8160: 8159: 8157: 8156: 8151: 8146: 8140: 8138: 8127: 8126: 8124: 8123: 8118: 8113: 8108: 8103: 8098: 8092: 8090: 8078: 8077: 8075: 8074: 8069: 8064: 8059: 8054: 8049: 8044: 8039: 8034: 8028: 8026: 8008: 8002: 8001: 7998: 7997: 7995: 7994: 7981: 7976: 7971: 7966: 7961: 7955: 7953: 7938: 7937: 7935: 7934: 7929: 7924: 7918: 7916: 7903: 7897: 7896: 7884: 7883: 7876: 7869: 7861: 7854: 7853: 7824: 7809: 7791:(11): 739–42. 7779: 7777: 7774: 7771: 7770: 7737: 7702: 7665: 7634: 7601: 7576: 7554: 7527: 7494: 7479:. 4 May 2020. 7464: 7434: 7404: 7377: 7350: 7320: 7284: 7254: 7220: 7188: 7158: 7132: 7103: 7067: 7032: 6989: 6953: 6909: 6887: 6845: 6819: 6789: 6782: 6764: 6745:(1): 357–366. 6727: 6712: 6677: 6627: 6596:(5): 1000–11. 6563: 6514: 6463: 6420: 6379: 6350:(5): 501–515. 6327: 6281: 6236: 6190: 6138: 6086: 6045: 6018:(2): 198–203. 6002: 5950: 5909: 5866: 5823: 5796:(4): 391–400. 5779: 5744: 5717:(3): 219–226. 5701: 5666: 5623: 5574: 5531: 5512:(6): 1367–75. 5496: 5477:(7): 1626–35. 5461: 5427:(8): 804–811. 5404: 5378: 5337: 5278: 5227: 5198:(2): 299–306. 5178: 5149:(4): 556–570. 5129: 5102:(3): 495–499. 5086: 5051: 5010: 4956: 4935:(6): 549–559. 4912: 4860: 4809: 4761: 4712: 4660: 4616: 4567: 4526: 4483: 4440: 4388: 4323: 4293: 4244: 4195: 4146: 4117:(6): 1316–25. 4097: 4068:(5): e014840. 4048: 4007: 3966: 3939:(9): 816–819. 3923: 3902:(5): 967–976. 3882: 3847: 3828:(5): 632–635. 3811: 3792:(3): 592–599. 3775: 3736: 3701: 3652: 3608: 3557: 3526:(10): e19473. 3503: 3433: 3406:(4): 305–316. 3382: 3346: 3299: 3280:(4): 562–570. 3261: 3240:(6): 881–892. 3217: 3176: 3125: 3081: 3040: 2996: 2960: 2911: 2873: 2854:(2): 109–124. 2837: 2830: 2812: 2793:(8): 1527–31. 2777: 2736: 2700: 2664: 2628: 2587: 2557: 2532: 2502: 2483: 2460: 2432: 2413: 2393: 2346: 2281: 2270:. 21 June 2022 2255: 2221: 2220: 2218: 2215: 2200: 2197: 2158: 2155: 2142: 2139: 2137: 2134: 2077: 2074: 2036:aldol reaction 2012:drug discovery 1987: 1984: 1970: 1967: 1961: 1956:people (>65 1947: 1943: 1933:P-glycoprotein 1904: 1901: 1881:beta-oxidation 1858: 1855: 1846: 1843: 1838: 1821: 1802: 1796: 1793: 1790: 1789: 1748: 1746: 1739: 1733: 1730: 1724: 1721: 1652:Main article: 1649: 1646: 1617: 1544:norethisterone 1476:clarithromycin 1437:rhabdomyolysis 1416: 1413: 1404: 1401: 1392: 1389: 1383: 1380: 1374: 1371: 1369: 1366: 1365: 1364: 1359: 1354: 1349: 1344: 1334: 1331: 1330: 1329: 1320: 1316: 1312: 1303: 1300: 1298: 1295: 1294: 1293: 1255:rhabdomyolysis 1243: 1237: 1231: 1211: 1208: 1207: 1206: 1199: 1192: 1188: 1184: 1181: 1178: 1172: 1169: 1152: 1151:Administration 1149: 1139: 1138:Kidney disease 1136: 1124: 1123: 1117: 1099: 1086: 1083: 1082: 1081: 1076: 1069: 1062: 1057: 1048: 1000: 997: 984: 981: 934:rhabdomyolysis 906: 905: 894: 893: 891: 890: 887: 885: 882: 874: 873: 872: 869: 868: 866: 865: 862: 854: 853: 852: 849: 848: 846: 845: 837: 835: 827: 826: 820: 814: 813: 810: 804: 795: 789: 784: 778: 777: 773: 772: 762: 754: 753: 751: 750: 737: 735: 722: 721: 719: 718: 702: 700: 694: 693: 691: 690: 682: 680: 674: 673: 671: 670: 662: 660: 654: 653: 651: 650: 642: 640: 634: 633: 631: 630: 622: 620: 614: 613: 611: 610: 602: 600: 594: 593: 591: 590: 582: 580: 574: 573: 571: 570: 562: 560: 554: 553: 551: 550: 542: 540: 529: 528: 526: 525: 517: 515: 509: 508: 506: 505: 494: 486: 485: 484: 481: 480: 476: 475: 470: 464: 463: 460: 451: 450: 440: 434: 433: 430: 424: 423: 416: 415: 413: 412: 384: 372: 359: 345: 343: 337: 336: 332: 331: 329: 328: 235: 233: 227: 226: 221: 219:administration 213: 212: 210: 209: 206: 196: 194: 186: 185: 183: 182: 164: 162: 156: 155: 148: 142: 141: 134: 124: 123: 120: 114: 113: 64: 60: 59: 55: 54: 46: 45: 26: 9: 6: 4: 3: 2: 8713: 8702: 8701:Hydroxy acids 8699: 8697: 8694: 8692: 8689: 8687: 8684: 8682: 8679: 8677: 8674: 8672: 8669: 8667: 8664: 8663: 8661: 8651: 8641: 8640: 8637: 8620: 8618: 8615: 8614: 8612: 8609: 8606: 8603: 8601: 8598: 8597: 8593: 8587: 8584: 8582: 8579: 8577: 8574: 8572: 8569: 8567: 8564: 8562: 8559: 8557: 8554: 8552: 8549: 8547: 8544: 8542: 8539: 8537: 8534: 8532: 8529: 8527: 8524: 8522: 8519: 8517: 8514: 8513: 8511: 8507: 8501: 8498: 8496: 8493: 8491: 8488: 8486: 8483: 8481: 8478: 8476: 8473: 8471: 8468: 8466: 8463: 8461: 8458: 8456: 8453: 8452: 8450: 8446: 8436: 8433: 8432: 8430: 8427: 8423: 8419: 8415: 8409: 8406: 8404: 8401: 8399: 8396: 8394: 8391: 8390: 8388: 8385: 8381: 8377: 8371: 8368: 8366: 8363: 8361: 8358: 8356: 8353: 8351: 8348: 8347: 8345: 8342: 8338: 8334: 8324: 8321: 8320: 8318: 8314: 8308: 8305: 8303: 8300: 8298: 8295: 8293: 8290: 8288: 8285: 8283: 8280: 8278: 8275: 8273: 8270: 8268: 8265: 8263: 8260: 8258: 8255: 8253: 8250: 8248: 8245: 8243: 8240: 8239: 8237: 8235: 8231: 8228: 8225: 8224:PPAR agonists 8221: 8218: 8216: 8215:Blood vessels 8212: 8202: 8199: 8197: 8194: 8193: 8191: 8188: 8187:Thyromimetics 8184: 8178: 8175: 8174: 8172: 8169: 8165: 8161: 8155: 8152: 8150: 8147: 8145: 8142: 8141: 8139: 8136: 8132: 8128: 8122: 8119: 8117: 8114: 8112: 8109: 8107: 8104: 8102: 8099: 8097: 8094: 8093: 8091: 8088: 8084: 8079: 8073: 8070: 8068: 8065: 8063: 8060: 8058: 8055: 8053: 8050: 8048: 8045: 8043: 8040: 8038: 8035: 8033: 8030: 8029: 8027: 8024: 8020: 8016: 8012: 8009: 8007: 8003: 7993: 7989: 7985: 7984:Soluble fiber 7982: 7980: 7977: 7975: 7974:Colestyramine 7972: 7970: 7967: 7965: 7962: 7960: 7957: 7956: 7954: 7951: 7947: 7943: 7939: 7933: 7930: 7928: 7925: 7923: 7920: 7919: 7917: 7915: 7911: 7907: 7904: 7902: 7898: 7893: 7889: 7882: 7877: 7875: 7870: 7868: 7863: 7862: 7859: 7842: 7838: 7837: 7831: 7825: 7821: 7820: 7815: 7810: 7806: 7802: 7798: 7794: 7790: 7786: 7781: 7780: 7758: 7754: 7753: 7748: 7741: 7725: 7721: 7720: 7714: 7706: 7690: 7686: 7682: 7681: 7676: 7669: 7653: 7649: 7645: 7638: 7622: 7618: 7614: 7608: 7606: 7590: 7586: 7580: 7564: 7558: 7542: 7538: 7531: 7515: 7511: 7509: 7504: 7498: 7482: 7478: 7474: 7468: 7452: 7448: 7444: 7438: 7422: 7418: 7414: 7408: 7392: 7388: 7381: 7365: 7361: 7354: 7338: 7334: 7330: 7324: 7305: 7301: 7294: 7288: 7272: 7268: 7264: 7258: 7242: 7238: 7234: 7230: 7224: 7205: 7198: 7192: 7176: 7172: 7168: 7162: 7146: 7142: 7136: 7120: 7116: 7110: 7108: 7088: 7084: 7077: 7071: 7055: 7051: 7050: 7044: 7036: 7028: 7024: 7020: 7016: 7012: 7008: 7004: 7000: 6993: 6977: 6973: 6972: 6967: 6960: 6958: 6938: 6934: 6930: 6923: 6916: 6914: 6900: 6894: 6892: 6875: 6871: 6870: 6864: 6856: 6854: 6852: 6850: 6841: 6840: 6835: 6828: 6826: 6824: 6807: 6803: 6799: 6793: 6785: 6779: 6775: 6768: 6760: 6756: 6752: 6748: 6744: 6741: 6740: 6739:J. Med. Chem. 6731: 6723: 6719: 6715: 6709: 6705: 6701: 6697: 6690: 6688: 6686: 6684: 6682: 6673: 6669: 6665: 6661: 6657: 6653: 6649: 6645: 6638: 6636: 6634: 6632: 6623: 6619: 6614: 6609: 6604: 6599: 6595: 6591: 6587: 6580: 6578: 6576: 6574: 6572: 6570: 6568: 6559: 6555: 6550: 6545: 6541: 6537: 6533: 6529: 6525: 6518: 6510: 6506: 6501: 6496: 6491: 6486: 6482: 6478: 6474: 6467: 6459: 6455: 6451: 6447: 6443: 6439: 6435: 6431: 6424: 6416: 6412: 6407: 6402: 6398: 6394: 6390: 6383: 6375: 6371: 6367: 6363: 6358: 6353: 6349: 6345: 6341: 6334: 6332: 6323: 6319: 6315: 6311: 6307: 6303: 6299: 6295: 6288: 6286: 6269: 6264: 6259: 6255: 6251: 6247: 6240: 6232: 6228: 6224: 6220: 6216: 6212: 6209:(2): 118–27. 6208: 6204: 6197: 6195: 6186: 6182: 6177: 6172: 6168: 6164: 6161:(3): 434–41. 6160: 6156: 6152: 6145: 6143: 6134: 6130: 6125: 6120: 6116: 6112: 6108: 6104: 6100: 6093: 6091: 6082: 6078: 6073: 6068: 6065:(9): 933–42. 6064: 6060: 6056: 6049: 6041: 6037: 6033: 6029: 6025: 6021: 6017: 6013: 6006: 5998: 5994: 5990: 5986: 5981: 5976: 5972: 5968: 5964: 5957: 5955: 5946: 5942: 5937: 5932: 5928: 5924: 5920: 5913: 5905: 5901: 5897: 5893: 5889: 5885: 5882:(2): 154–67. 5881: 5877: 5870: 5862: 5858: 5854: 5850: 5846: 5842: 5839:(6): 565–81. 5838: 5834: 5827: 5819: 5815: 5811: 5807: 5803: 5799: 5795: 5791: 5783: 5775: 5771: 5767: 5763: 5759: 5755: 5748: 5740: 5736: 5732: 5728: 5724: 5720: 5716: 5712: 5705: 5697: 5693: 5689: 5685: 5681: 5677: 5670: 5662: 5658: 5654: 5650: 5646: 5642: 5638: 5634: 5627: 5619: 5615: 5610: 5605: 5601: 5597: 5593: 5589: 5585: 5578: 5570: 5566: 5562: 5558: 5554: 5550: 5546: 5542: 5535: 5527: 5523: 5519: 5515: 5511: 5507: 5500: 5492: 5488: 5484: 5480: 5476: 5472: 5465: 5446: 5442: 5438: 5434: 5430: 5426: 5422: 5415: 5408: 5392: 5388: 5382: 5374: 5370: 5365: 5360: 5356: 5352: 5348: 5341: 5333: 5329: 5324: 5319: 5314: 5309: 5305: 5301: 5297: 5293: 5289: 5282: 5274: 5270: 5265: 5260: 5255: 5250: 5247:(3): 348–58. 5246: 5242: 5238: 5231: 5223: 5219: 5214: 5209: 5205: 5201: 5197: 5193: 5189: 5182: 5174: 5170: 5166: 5162: 5157: 5152: 5148: 5144: 5140: 5133: 5125: 5121: 5117: 5113: 5109: 5105: 5101: 5097: 5090: 5082: 5078: 5074: 5070: 5066: 5062: 5055: 5047: 5043: 5038: 5033: 5029: 5025: 5021: 5014: 5006: 5002: 4997: 4992: 4987: 4982: 4978: 4974: 4970: 4963: 4961: 4952: 4948: 4943: 4938: 4934: 4930: 4926: 4919: 4917: 4908: 4904: 4899: 4894: 4890: 4886: 4882: 4878: 4874: 4867: 4865: 4856: 4852: 4847: 4842: 4837: 4832: 4828: 4824: 4820: 4813: 4805: 4801: 4796: 4791: 4787: 4783: 4779: 4772: 4770: 4768: 4766: 4757: 4753: 4748: 4743: 4739: 4735: 4731: 4727: 4723: 4716: 4708: 4704: 4699: 4694: 4690: 4686: 4682: 4678: 4674: 4667: 4665: 4656: 4652: 4648: 4644: 4640: 4636: 4632: 4628: 4620: 4612: 4608: 4604: 4600: 4595: 4590: 4586: 4582: 4578: 4571: 4563: 4559: 4554: 4549: 4545: 4541: 4537: 4530: 4522: 4518: 4514: 4510: 4506: 4502: 4498: 4494: 4487: 4479: 4475: 4471: 4467: 4463: 4459: 4455: 4451: 4444: 4436: 4432: 4428: 4424: 4420: 4416: 4413:(5): 343–70. 4412: 4408: 4401: 4399: 4397: 4395: 4393: 4373: 4369: 4365: 4361: 4357: 4353: 4349: 4345: 4341: 4334: 4327: 4311: 4307: 4303: 4297: 4289: 4285: 4280: 4275: 4271: 4267: 4263: 4259: 4255: 4248: 4240: 4236: 4231: 4226: 4222: 4218: 4214: 4210: 4206: 4199: 4191: 4187: 4182: 4177: 4173: 4169: 4165: 4161: 4157: 4150: 4142: 4138: 4133: 4128: 4124: 4120: 4116: 4112: 4108: 4101: 4093: 4089: 4084: 4079: 4075: 4071: 4067: 4063: 4059: 4052: 4044: 4040: 4035: 4030: 4026: 4022: 4018: 4011: 4003: 3999: 3994: 3989: 3986:(3): 238–48. 3985: 3981: 3977: 3970: 3962: 3958: 3954: 3950: 3946: 3942: 3938: 3934: 3927: 3919: 3915: 3910: 3905: 3901: 3897: 3893: 3886: 3878: 3874: 3870: 3866: 3862: 3858: 3851: 3843: 3839: 3835: 3831: 3827: 3823: 3815: 3807: 3803: 3799: 3795: 3791: 3787: 3779: 3771: 3767: 3763: 3759: 3755: 3751: 3743: 3741: 3732: 3728: 3724: 3720: 3716: 3712: 3705: 3697: 3693: 3688: 3683: 3679: 3675: 3671: 3667: 3663: 3656: 3648: 3644: 3640: 3636: 3632: 3628: 3624: 3620: 3612: 3604: 3600: 3595: 3590: 3585: 3580: 3577:: 3685–3690. 3576: 3572: 3568: 3561: 3553: 3549: 3544: 3539: 3534: 3529: 3525: 3521: 3517: 3510: 3508: 3488: 3484: 3480: 3476: 3472: 3468: 3464: 3460: 3456: 3449: 3442: 3440: 3438: 3429: 3425: 3421: 3417: 3413: 3409: 3405: 3401: 3393: 3391: 3389: 3387: 3378: 3374: 3370: 3366: 3362: 3358: 3350: 3342: 3338: 3334: 3330: 3326: 3322: 3318: 3314: 3306: 3304: 3295: 3291: 3287: 3283: 3279: 3275: 3268: 3266: 3257: 3253: 3248: 3243: 3239: 3235: 3231: 3224: 3222: 3213: 3209: 3204: 3199: 3195: 3191: 3187: 3180: 3172: 3168: 3163: 3158: 3153: 3148: 3144: 3140: 3136: 3129: 3121: 3117: 3113: 3109: 3105: 3101: 3098:(6): 355–62. 3097: 3093: 3085: 3077: 3073: 3068: 3063: 3059: 3055: 3054:Diabetes Care 3051: 3044: 3036: 3032: 3028: 3024: 3020: 3016: 3012: 3008: 3000: 2992: 2988: 2984: 2980: 2976: 2972: 2964: 2956: 2952: 2947: 2942: 2938: 2934: 2930: 2926: 2922: 2915: 2907: 2903: 2899: 2895: 2891: 2887: 2880: 2878: 2869: 2865: 2861: 2857: 2853: 2849: 2841: 2833: 2827: 2823: 2816: 2808: 2804: 2800: 2796: 2792: 2788: 2781: 2773: 2769: 2764: 2759: 2755: 2751: 2747: 2740: 2732: 2728: 2724: 2720: 2717:(2): 128–33. 2716: 2712: 2704: 2696: 2692: 2688: 2684: 2681:(5): 678–82. 2680: 2676: 2668: 2660: 2656: 2652: 2648: 2644: 2640: 2632: 2624: 2620: 2616: 2612: 2608: 2604: 2596: 2594: 2592: 2575: 2571: 2567: 2561: 2546: 2542: 2536: 2520: 2516: 2512: 2506: 2490: 2486: 2480: 2476: 2475: 2467: 2465: 2455: 2450: 2446: 2442: 2436: 2420: 2416: 2414:9783527607495 2410: 2406: 2405: 2397: 2381: 2377: 2373: 2367: 2365: 2363: 2361: 2359: 2357: 2355: 2353: 2351: 2334: 2330: 2326: 2320: 2318: 2316: 2314: 2312: 2310: 2308: 2306: 2304: 2302: 2300: 2298: 2296: 2294: 2292: 2290: 2288: 2286: 2269: 2265: 2259: 2243: 2239: 2235: 2229: 2227: 2222: 2214: 2206: 2196: 2194: 2189: 2185: 2183: 2179: 2174: 2172: 2163: 2154: 2152: 2148: 2133: 2130: 2114: 2111: 2110: 2104: 2102: 2098: 2094: 2090: 2086: 2082: 2073: 2071: 2067: 2064: 2059: 2057: 2053: 2048: 2044: 2039: 2037: 2033: 2029: 2025: 2021: 2017: 2013: 2004: 1997: 1992: 1983: 1979: 1976: 1975:polymorphisms 1966: 1955: 1951: 1941: 1936: 1934: 1929: 1925: 1921: 1917: 1913: 1910: 1900: 1898: 1894: 1890: 1886: 1882: 1878: 1874: 1873:hydroxylation 1871: 1868: 1864: 1861:Atorvastatin 1854: 1852: 1842: 1836: 1832: 1828: 1824: 1817: 1813: 1809: 1805: 1786: 1783: 1775: 1772:December 2017 1765: 1761: 1755: 1754: 1749:This section 1747: 1743: 1738: 1737: 1729: 1720: 1718: 1714: 1709: 1707: 1703: 1702:triglycerides 1699: 1695: 1694:LDL receptors 1691: 1690: 1685: 1681: 1677: 1674:(HMG-CoA) to 1673: 1669: 1665: 1661: 1655: 1645: 1643: 1638: 1636: 1632: 1628: 1624: 1620: 1613: 1609: 1607: 1603: 1599: 1595: 1593: 1588: 1584: 1580: 1576: 1571: 1569: 1565: 1563: 1559: 1555: 1551: 1549: 1545: 1541: 1537: 1533: 1529: 1528:oxcarbazepine 1525: 1521: 1517: 1516:carbamazepine 1513: 1509: 1505: 1501: 1497: 1493: 1489: 1485: 1481: 1477: 1473: 1469: 1465: 1461: 1457: 1453: 1452:telithromycin 1449: 1445: 1440: 1438: 1434: 1430: 1426: 1422: 1412: 1410: 1400: 1398: 1388: 1379: 1363: 1360: 1358: 1355: 1353: 1350: 1348: 1345: 1343: 1340: 1339: 1338: 1326: 1321: 1317: 1313: 1309: 1306: 1305: 1291: 1288: 1284: 1280: 1276: 1272: 1268: 1264: 1263:myoglobinuria 1260: 1256: 1252: 1248: 1244: 1241: 1240:Breastfeeding 1238: 1235: 1232: 1230: 1226: 1222: 1218: 1214: 1213: 1204: 1200: 1197: 1193: 1189: 1185: 1182: 1179: 1175: 1174: 1168: 1164: 1162: 1158: 1148: 1144: 1135: 1133: 1129: 1122: 1118: 1115: 1111: 1107: 1103: 1100: 1097: 1092: 1089: 1088: 1080: 1077: 1074: 1070: 1067: 1063: 1061: 1058: 1056: 1052: 1049: 1046: 1042: 1038: 1037:triglycerides 1034: 1030: 1026: 1022: 1018: 1014: 1010: 1006: 1003: 1002: 996: 994: 990: 980: 974: 970: 965: 963: 959: 956:found in the 955: 951: 947: 944:may harm the 943: 940:. Use during 939: 935: 930: 928: 924: 920: 916: 912: 902: 895: 886: 881: 880: 877: 870: 861: 860: 857: 850: 843: 839: 838: 836: 833: 828: 821: 819: 815: 785: 783: 779: 774: 770: 766: 763: 761: 759:ECHA InfoCard 755: 747: 743: 742:DTXSID8029868 739: 738: 736: 727: 723: 715: 714:RCSB PDB 709: 704: 703: 701: 699: 695: 688: 684: 683: 681: 679: 675: 668: 664: 663: 661: 659: 655: 648: 644: 643: 641: 639: 635: 628: 624: 623: 621: 619: 615: 608: 604: 603: 601: 599: 595: 588: 584: 583: 581: 579: 575: 568: 564: 563: 561: 559: 555: 548: 544: 543: 541: 534: 530: 523: 519: 518: 516: 514: 510: 502: 498: 493: 492: 489: 482: 477: 474: 471: 469: 465: 461: 459: 452: 448: 444: 441: 439: 435: 431: 429: 425: 421: 417: 400: 396: 392: Rx-only 385: 383: 373: 370: 360: 357: 347: 346: 344: 342: 338: 333: 325: 320: 315: 310: 305: 300: 295: 290: 285: 280: 275: 270: 265: 260: 255: 250: 245: 240: 237: 236: 234: 232: 228: 225: 222: 220: 214: 207: 198: 197: 195: 193: 187: 180: 175: 166: 165: 163: 161: 157: 153: 149: 147: 143: 139: 135: 133: 129: 125: 121: 119: 115: 109: 65: 63:Pronunciation 61: 58:Clinical data 56: 52: 47: 43: 38: 30: 19: 8586:Volanesorsen 8448:Combinations 8420:inhibitors ( 8262:Clinofibrate 8257:Ciprofibrate 8166:inhibitors ( 8133:inhibitors ( 8116:Nicofuranose 8067:Rosuvastatin 8057:Pitavastatin 8037:Cerivastatin 8032:Atorvastatin 8031: 7845:. Retrieved 7834: 7817: 7788: 7784: 7761:. Retrieved 7750: 7740: 7728:. Retrieved 7717: 7705: 7693:. Retrieved 7678: 7668: 7656:. Retrieved 7647: 7637: 7625:. Retrieved 7592:. Retrieved 7588: 7579: 7567:. Retrieved 7557: 7545:. Retrieved 7541:the original 7530: 7518:. Retrieved 7506: 7497: 7485:. Retrieved 7476: 7467: 7455:. Retrieved 7451:the original 7437: 7425:. Retrieved 7416: 7407: 7395:. Retrieved 7391:the original 7380: 7368:. Retrieved 7364:the original 7353: 7341:. Retrieved 7332: 7323: 7311:. Retrieved 7299: 7287: 7275:. Retrieved 7266: 7257: 7245:. Retrieved 7236: 7232: 7223: 7211:. Retrieved 7191: 7179:. Retrieved 7161: 7149:. Retrieved 7135: 7123:. Retrieved 7094:. Retrieved 7070: 7058:. Retrieved 7047: 7035: 7002: 6998: 6992: 6980:. Retrieved 6969: 6944:. Retrieved 6935:(1): 28–34. 6932: 6928: 6878:. Retrieved 6867: 6837: 6810:. Retrieved 6801: 6792: 6773: 6767: 6742: 6737: 6730: 6695: 6650:(6): 352–8. 6647: 6643: 6593: 6589: 6531: 6527: 6517: 6480: 6476: 6466: 6436:(1): 55–62. 6433: 6429: 6423: 6396: 6392: 6382: 6347: 6343: 6297: 6293: 6272:. Retrieved 6256:(2): 40–42. 6253: 6249: 6239: 6206: 6202: 6158: 6154: 6109:(5): 494–7. 6106: 6102: 6062: 6058: 6048: 6015: 6011: 6005: 5970: 5966: 5926: 5922: 5912: 5879: 5875: 5869: 5836: 5832: 5826: 5793: 5789: 5782: 5757: 5753: 5747: 5714: 5710: 5704: 5679: 5675: 5669: 5636: 5632: 5626: 5594:(1): 25–28. 5591: 5587: 5577: 5544: 5540: 5534: 5509: 5505: 5499: 5474: 5470: 5464: 5452:. Retrieved 5424: 5420: 5407: 5395:. Retrieved 5381: 5354: 5350: 5340: 5295: 5291: 5281: 5244: 5240: 5230: 5195: 5192:Diabetologia 5191: 5181: 5146: 5142: 5132: 5099: 5095: 5089: 5067:(6): 670–6. 5064: 5060: 5054: 5027: 5023: 5013: 4976: 4972: 4932: 4928: 4880: 4876: 4826: 4823:BMC Medicine 4822: 4812: 4785: 4781: 4729: 4725: 4715: 4680: 4676: 4630: 4626: 4619: 4584: 4580: 4570: 4543: 4539: 4529: 4496: 4492: 4486: 4453: 4449: 4443: 4410: 4406: 4379:. Retrieved 4346:(6): 532–9. 4343: 4339: 4326: 4314:. Retrieved 4305: 4296: 4261: 4257: 4247: 4212: 4208: 4198: 4163: 4159: 4149: 4114: 4110: 4100: 4065: 4061: 4051: 4024: 4020: 4010: 3983: 3979: 3969: 3936: 3932: 3926: 3899: 3895: 3885: 3860: 3856: 3850: 3825: 3821: 3814: 3789: 3785: 3778: 3756:(1): 44–47. 3753: 3749: 3714: 3710: 3704: 3669: 3665: 3655: 3622: 3618: 3611: 3574: 3570: 3560: 3523: 3519: 3494:. Retrieved 3458: 3454: 3403: 3399: 3360: 3356: 3349: 3316: 3312: 3277: 3273: 3237: 3233: 3193: 3189: 3179: 3142: 3139:BMC Medicine 3138: 3128: 3095: 3091: 3084: 3057: 3053: 3043: 3010: 3006: 2999: 2974: 2970: 2963: 2928: 2924: 2914: 2889: 2885: 2851: 2847: 2840: 2821: 2815: 2790: 2786: 2780: 2756:(4): 216–9. 2753: 2749: 2739: 2714: 2710: 2703: 2678: 2674: 2667: 2642: 2638: 2631: 2609:(1): 74–80. 2606: 2602: 2578:. Retrieved 2560: 2548:. Retrieved 2544: 2535: 2523:. Retrieved 2514: 2505: 2493:. Retrieved 2473: 2454:10665/371090 2444: 2435: 2423:. Retrieved 2403: 2396: 2384:. Retrieved 2375: 2337:. Retrieved 2328: 2272:. Retrieved 2267: 2258: 2246:. Retrieved 2237: 2202: 2190: 2186: 2180:and India's 2175: 2168: 2144: 2131: 2115: 2107: 2105: 2079: 2062: 2060: 2040: 2018:followed by 2009: 1980: 1972: 1952: 1937: 1906: 1897:erythromycin 1892: 1860: 1848: 1845:Distribution 1798: 1778: 1769: 1758:Please help 1753:verification 1750: 1726: 1710: 1687: 1657: 1639: 1631:heart attack 1610: 1596: 1592:pitavastatin 1572: 1566: 1552: 1512:barbiturates 1504:fosphenytoin 1480:cyclosporine 1472:ketoconazole 1464:erythromycin 1456:voriconazole 1448:itraconazole 1441: 1418: 1415:Interactions 1406: 1397:triglyceride 1394: 1391:Pancreatitis 1385: 1376: 1347:Loose stools 1336: 1297:Side effects 1279:erythromycin 1271:cyclosporine 1165: 1154: 1145: 1141: 1125: 1039:levels, and 1013:dyslipidemia 1011:) and mixed 999:Dyslipidemia 989:dyslipidemia 986: 983:Medical uses 966: 931: 911:Atorvastatin 910: 909: 898: 500: 496: 455:Elimination 411:</ref> 403:. Retrieved 398: 341:Legal status 335:Legal status 179:Atorvastatin 160:License data 34:Atorvastatin 29: 8607:from market 8566:Policosanol 8541:Lapaquistat 8521:Azacosterol 8398:Bococizumab 8370:Torcetrapib 8365:Obicetrapib 8360:Evacetrapib 8355:Dalcetrapib 8350:Anacetrapib 8302:Ronifibrate 8297:Pemafibrate 8287:Gemfibrozil 8282:Fenofibrate 8247:Bezafibrate 8154:Mitratapide 8144:Dirlotapide 8072:Simvastatin 8062:Pravastatin 8042:Fluvastatin 7992:glucomannan 7959:Colesevelam 7763:29 December 7695:29 December 7181:18 November 7125:24 November 6982:18 February 6880:24 November 5967:Circulation 5298:(1): 5804. 5024:Circulation 4979:: 211–219. 4540:Circulation 4381:28 December 2386:23 December 2339:26 February 2248:26 February 2157:Brand names 2101:simvastatin 2093:orphan drug 2052:chiral pool 2026:. An early 2024:enantiomers 1996:chiral pool 1877:metabolites 1698:hepatocytes 1684:cholesterol 1682:in hepatic 1606:cholesterol 1468:fluconazole 1429:fenofibrate 1425:gemfibrozil 1357:Muscle pain 1352:Indigestion 1290:antifungals 1217:cholestasis 1025:cholesterol 962:cholesterol 825: g·mol 765:100.125.464 667:CHEBI:39548 522:134523-00-5 479:Identifiers 405:26 February 146:MedlinePlus 118:Trade names 8660:Categories 8581:Triparanol 8556:Mipomersen 8536:Darapladib 8531:Benfluorex 8526:Azalanstat 8435:Evinacumab 8408:Inclisiran 8403:Evolocumab 8393:Alirocumab 8307:Simfibrate 8277:Etofibrate 8272:Clofibride 8267:Clofibrate 8201:Resmetirom 8149:Lomitapide 8111:Niceritrol 8052:Mevastatin 8047:Lovastatin 7969:Colestipol 7964:Colestilan 7927:Hyzetimibe 7847:26 October 7060:26 October 6300:: 105735. 5454:23 January 5397:7 November 3863:(1): 1–9. 3145:(1): 229. 2217:References 2109:The Lancet 2081:Bruce Roth 1998:approach). 1863:metabolism 1857:Metabolism 1833:-lowering 1795:Absorption 1676:mevalonate 1642:colchicine 1560:-lowering 1524:nevirapine 1496:aprepitant 1492:amiodarone 1342:Joint pain 1328:physician. 830:3D model ( 818:Molar mass 698:PDB ligand 687:ChEMBL1487 627:A0JWA85V8F 598:ChemSpider 558:IUPHAR/BPS 513:CAS Number 488:IUPAC name 438:Metabolism 8617:Phase III 8605:Withdrawn 8292:Nafenopin 7979:Colextran 7932:SCH-48461 7922:Ezetimibe 7585:"Lipitor" 7477:Drugs.com 7202:. Cigna. 7151:19 August 6458:195685309 6322:212408322 4829:(1): 51. 3400:Angiology 2550:30 August 2525:30 August 2376:Drugs.com 2238:Drugs.com 2141:Economics 1954:Geriatric 1928:half-life 1903:Excretion 1849:The mean 1668:synthetic 1660:inhibitor 1629:(such as 1598:Vitamin D 1536:rifamycin 1520:efavirenz 1508:phenytoin 1498:. Often, 1488:verapamil 1460:diltiazem 1382:Cognitive 1234:Pregnancy 1225:hepatitis 1203:cirrhosis 942:pregnancy 587:APRD00055 473:Bile duct 468:Excretion 457:half-life 395:"Lipitor" 217:Routes of 190:Pregnancy 138:Monograph 132:Drugs.com 8691:Pyrroles 8666:Anilides 8650:Medicine 8576:Tiadenol 8571:Probucol 8551:Meglutol 8323:GW501516 8234:Fibrates 8096:Acipimox 7988:psyllium 7986:such as 7901:GI tract 7841:Archived 7805:15922927 7757:Archived 7724:Archived 7689:Archived 7652:Archived 7627:19 April 7621:Archived 7514:Archived 7481:Archived 7427:12 April 7421:Archived 7337:Archived 7304:Archived 7271:Archived 7247:31 March 7241:Archived 7213:30 March 7204:Archived 7175:Archived 7145:Archived 7119:Archived 7087:Archived 7054:Archived 6976:Archived 6946:12 March 6937:Archived 6874:Archived 6806:Archived 6722:12516521 6664:16103896 6622:22368281 6558:24810685 6509:25760954 6450:17910521 6415:22581818 6374:28738671 6366:24601937 6314:32126319 6268:Archived 6223:10460065 6185:21501216 6133:16236039 6081:10994829 6040:23604512 6032:18754003 5997:19169932 5989:27754879 5945:15901588 5896:16084850 5861:35917120 5853:17178259 5818:26375921 5810:11061579 5774:12843167 5731:23324122 5696:21094360 5661:23785176 5653:11485144 5569:22429669 5561:15572716 5526:24628781 5491:24684744 5445:Archived 5441:22910758 5391:Archived 5373:31753200 5332:29643479 5273:25575908 5222:26577796 5173:19151464 5165:29733433 5116:19188844 5081:12972104 5046:17159064 5005:34795533 4951:16899775 4907:21067805 4855:24655568 4804:15755765 4756:36049498 4707:21067804 4647:12686036 4611:64660561 4603:21453832 4562:23109518 4521:11544414 4513:20167359 4478:22626629 4470:27277934 4427:12036392 4372:Archived 4368:12838555 4360:16765141 4310:Archived 4302:"TOXNET" 4288:34967881 4239:28479502 4190:21663949 4141:21493741 4092:32089045 4043:19332456 4002:16034009 3918:12686673 3877:17606955 3842:17317362 3806:21297502 3770:16377282 3731:35512427 3696:20228404 3647:40744740 3639:16310551 3603:30464400 3552:32150109 3520:Medicine 3487:Archived 3475:29404930 3428:52875826 3420:30261736 3377:28242291 3333:25147328 3294:25001155 3256:26905361 3212:22085316 3171:26385210 3120:27148191 3112:11225965 3076:17065671 3035:28885209 3027:15325833 2991:14996776 2955:12829554 2906:15755765 2868:20934984 2772:16908955 2659:16533939 2623:12915827 2574:Archived 2545:ClinCalc 2519:Archived 2515:ClinCalc 2489:Archived 2443:(2023). 2419:Archived 2380:Archived 2378:. AHFS. 2333:Archived 2329:DailyMed 2274:30 March 2242:Archived 1893:in vitro 1835:efficacy 1575:warfarin 1562:efficacy 1554:Antacids 1532:rifampin 1500:bosentan 1433:myopathy 1399:levels. 1267:myopathy 1251:myopathy 1229:jaundice 1161:fibrates 1055:children 938:diabetes 927:by mouth 901:(verify) 578:DrugBank 462:14 hours 231:ATC code 224:By mouth 192:category 174:DailyMed 8696:Statins 8418:ANGPTL3 8015:Statins 7819:Fortune 7730:21 June 7658:6 March 7615:. U.S. 7594:17 June 7569:17 June 7547:16 July 7457:31 July 7300:Uhc.com 7096:21 June 7085:(FDA). 7081:. U.S. 7027:5965882 7019:7968073 6839:Fortune 6759:1992137 6672:5928092 6613:3329377 6549:4676271 6500:6464917 6231:8103490 6176:3175512 6124:1884940 5904:8715786 5739:9148062 5618:9929751 5609:6655916 5323:5895617 5300:Bibcode 5264:4351273 5213:4705133 5124:2955398 4996:8593596 4898:2988223 4846:3998050 4747:7613583 4698:2988224 4655:9409142 4435:8759303 4279:8719244 4230:5605397 4181:3145073 4132:3109927 4083:7335561 3953:9549635 3687:2879499 3594:6216974 3543:7478506 3483:3295220 3341:6575836 3162:4575433 2807:9301631 2731:8531308 2695:7749881 2580:3 April 2495:27 June 2193:Viatris 2097:Mevacor 2076:History 2070:calcium 2066:complex 2016:racemic 1912:biliary 1909:hepatic 1689:de novo 1579:digoxin 1261:due to 1187:health. 1047:levels. 823:558.650 782:Formula 533:PubChem 321: ( 319:C10BX11 311: ( 309:C10BX06 301: ( 299:C10BX12 291: ( 289:C10BX15 281: ( 279:C10BA08 271: ( 269:C10BA05 261: ( 259:C10BX03 251: ( 249:C10BX08 247:) 241: ( 239:C10AA05 205: D 176:: 152:a600045 18:Lipitor 8636:Portal 8600:WHO-EM 8316:Others 8189:(VLDL) 8106:Niacin 7946:resins 7914:NPC1L1 7803: 7589:Pfizer 7520:10 May 7487:10 May 7313:25 May 7025: 7017: 6999:Lancet 6905: 6812:25 May 6780: 6757: 6720: 6710: 6670: 6662: 6620: 6610: 6556: 6546: 6507: 6497: 6456: 6448: 6413: 6393:Stroke 6372: 6364: 6320: 6312: 6274:10 May 6229: 6221: 6183: 6173: 6131: 6121: 6079: 6038: 6030: 5995: 5987: 5943: 5902: 5894: 5859: 5851: 5816: 5808: 5772: 5737: 5729: 5694: 5659: 5651: 5616: 5606: 5567: 5559: 5524: 5489: 5439: 5371: 5330: 5320: 5271: 5261: 5220: 5210: 5171: 5163: 5122: 5114: 5079: 5044: 5003: 4993: 4949: 4905: 4895: 4877:Lancet 4853: 4843: 4802: 4754: 4744: 4726:Lancet 4705: 4695: 4677:Lancet 4653: 4645: 4627:Lancet 4609: 4601: 4560: 4519: 4511: 4493:Lancet 4476: 4468: 4433: 4425: 4366: 4358: 4316:29 May 4286: 4276: 4237: 4227: 4188: 4178: 4160:Lancet 4139: 4129: 4090: 4080: 4041: 4000: 3961:752038 3959: 3951: 3916: 3875: 3840: 3804: 3768: 3729: 3694: 3684: 3645: 3637: 3619:Lancet 3601: 3591: 3550: 3540: 3481: 3473: 3426: 3418: 3375: 3339: 3331: 3313:Stroke 3292: 3254: 3210: 3169: 3159: 3118: 3110: 3074: 3033: 3025: 3007:Lancet 2989: 2953: 2946:162260 2943: 2904: 2866: 2828: 2805: 2770: 2729: 2693: 2657: 2621: 2481: 2425:10 May 2411: 2210: 2208:than 1 2127: 2123: 2118: 2085:me-too 1958: 1654:Statin 1568:Niacin 1534:, and 1506:, and 1454:, and 1444:CYP3A4 1362:Nausea 1333:Common 1285:, and 1283:niacin 1227:, and 1128:statin 1110:stroke 977: 954:enzyme 915:statin 856:SMILES 678:ChEMBL 647:D07474 447:CYP3A4 382:℞-only 380: 367: 354: 172: 112: 8671:Diols 8509:Other 8226:(LDL) 8006:Liver 7510:(EMA) 7417:PM360 7397:3 May 7370:3 May 7343:7 May 7307:(PDF) 7296:(PDF) 7277:7 May 7207:(PDF) 7200:(PDF) 7090:(PDF) 7079:(PDF) 7023:S2CID 6940:(PDF) 6925:(PDF) 6668:S2CID 6454:S2CID 6430:Drugs 6370:S2CID 6318:S2CID 6227:S2CID 6036:S2CID 5993:S2CID 5900:S2CID 5857:S2CID 5814:S2CID 5735:S2CID 5657:S2CID 5565:S2CID 5448:(PDF) 5417:(PDF) 5169:S2CID 5120:S2CID 4651:S2CID 4607:S2CID 4517:S2CID 4474:S2CID 4431:S2CID 4375:(PDF) 4364:S2CID 4336:(PDF) 3957:S2CID 3643:S2CID 3496:9 May 3490:(PDF) 3479:S2CID 3451:(PDF) 3424:S2CID 3337:S2CID 3116:S2CID 3031:S2CID 1916:urine 1831:LDL-C 1696:) on 1558:LDL-C 1486:, or 1368:Other 1302:Major 1287:azole 1033:apo-B 1029:LDL-C 958:liver 952:, an 946:fetus 913:is a 876:InChI 832:JSmol 705:117 ( 658:ChEBI 607:54810 547:60823 443:Liver 8135:VLDL 8131:MTTP 8085:and 7990:and 7849:2011 7801:PMID 7765:2017 7732:2019 7697:2017 7660:2021 7629:2014 7596:2024 7571:2024 7549:2014 7522:2020 7489:2020 7459:2012 7429:2020 7399:2012 7372:2012 7345:2022 7315:2022 7279:2022 7249:2020 7215:2020 7183:2012 7153:2022 7127:2011 7098:2019 7062:2011 7015:PMID 6984:2017 6948:2020 6882:2015 6814:2022 6778:ISBN 6755:PMID 6718:PMID 6708:ISBN 6660:PMID 6618:PMID 6554:PMID 6505:PMID 6481:2015 6446:PMID 6411:PMID 6362:PMID 6310:PMID 6276:2020 6219:PMID 6181:PMID 6129:PMID 6077:PMID 6028:PMID 5985:PMID 5941:PMID 5892:PMID 5849:PMID 5806:PMID 5770:PMID 5727:PMID 5692:PMID 5649:PMID 5614:PMID 5557:PMID 5541:JAMA 5522:PMID 5487:PMID 5456:2023 5437:PMID 5421:JAMA 5399:2021 5369:PMID 5328:PMID 5269:PMID 5218:PMID 5161:PMID 5112:PMID 5077:PMID 5042:PMID 5001:PMID 4947:PMID 4903:PMID 4851:PMID 4800:PMID 4752:PMID 4703:PMID 4643:PMID 4599:PMID 4558:PMID 4509:PMID 4466:PMID 4423:PMID 4383:2020 4356:PMID 4318:2018 4284:PMID 4235:PMID 4186:PMID 4137:PMID 4088:PMID 4039:PMID 3998:PMID 3949:PMID 3914:PMID 3873:PMID 3838:PMID 3802:PMID 3766:PMID 3727:PMID 3692:PMID 3635:PMID 3599:PMID 3548:PMID 3498:2020 3471:PMID 3416:PMID 3373:PMID 3329:PMID 3290:PMID 3252:PMID 3208:PMID 3167:PMID 3108:PMID 3072:PMID 3023:PMID 2987:PMID 2971:JAMA 2951:PMID 2902:PMID 2864:PMID 2826:ISBN 2803:PMID 2768:PMID 2727:PMID 2711:JAMA 2691:PMID 2655:PMID 2639:JAMA 2619:PMID 2582:2011 2552:2024 2527:2024 2497:2022 2479:ISBN 2427:2020 2409:ISBN 2388:2018 2341:2020 2276:2024 2250:2020 2061:The 2014:was 1920:Bile 1621:and 1546:and 1494:and 1435:and 1177:age. 1019:and 708:PDBe 638:KEGG 618:UNII 567:2949 422:data 407:2023 128:AHFS 8426:HDL 8422:LDL 8384:LDL 8341:HDL 8168:LDL 8087:LDL 8083:HDL 8023:LDL 7950:LDL 7892:C10 7793:doi 7333:CMS 7171:CNN 7007:doi 7003:344 6747:doi 6700:doi 6652:doi 6608:PMC 6598:doi 6544:PMC 6536:doi 6495:PMC 6485:doi 6438:doi 6401:doi 6352:doi 6302:doi 6298:122 6258:doi 6211:doi 6171:PMC 6163:doi 6119:PMC 6111:doi 6067:doi 6020:doi 5975:doi 5971:134 5931:doi 5884:doi 5841:doi 5798:doi 5762:doi 5719:doi 5684:doi 5680:106 5641:doi 5604:PMC 5596:doi 5549:doi 5545:292 5514:doi 5479:doi 5429:doi 5425:308 5359:doi 5318:PMC 5308:doi 5259:PMC 5249:doi 5208:PMC 5200:doi 5151:doi 5104:doi 5069:doi 5032:doi 5028:114 4991:PMC 4981:doi 4937:doi 4933:355 4893:PMC 4885:doi 4881:376 4841:PMC 4831:doi 4790:doi 4786:352 4742:PMC 4734:doi 4730:400 4693:PMC 4685:doi 4681:376 4635:doi 4631:361 4589:doi 4548:doi 4544:126 4501:doi 4497:375 4458:doi 4415:doi 4348:doi 4274:PMC 4266:doi 4225:PMC 4217:doi 4176:PMC 4168:doi 4164:377 4127:PMC 4119:doi 4078:PMC 4070:doi 4029:doi 4025:360 3988:doi 3984:353 3941:doi 3904:doi 3865:doi 3861:147 3830:doi 3794:doi 3758:doi 3719:doi 3682:PMC 3674:doi 3670:362 3627:doi 3623:366 3589:PMC 3579:doi 3538:PMC 3528:doi 3463:doi 3408:doi 3365:doi 3321:doi 3282:doi 3278:114 3242:doi 3198:doi 3194:365 3157:PMC 3147:doi 3100:doi 3062:doi 3015:doi 3011:364 2979:doi 2975:291 2941:PMC 2933:doi 2929:326 2925:BMJ 2894:doi 2890:352 2856:doi 2852:104 2848:QJM 2795:doi 2758:doi 2719:doi 2715:275 2683:doi 2647:doi 2643:295 2611:doi 2607:143 2449:hdl 2121:125 2091:'s 1962:max 1948:max 1944:max 1938:In 1870:3A4 1839:max 1827:AUC 1822:max 1803:max 1762:by 1662:of 1633:or 1618:max 1594:). 1577:or 1247:CPK 1053:in 1045:HDL 1041:CRP 1021:IIb 731:EPA 537:CID 432:12% 369:POM 324:WHO 314:WHO 304:WHO 294:WHO 284:WHO 274:WHO 264:WHO 254:WHO 244:WHO 81:ɔːr 8662:: 8613:: 8021:, 7912:, 7839:. 7833:. 7816:. 7799:. 7789:10 7787:. 7755:. 7749:. 7722:. 7716:. 7687:. 7683:. 7677:. 7650:. 7646:. 7604:^ 7587:. 7505:. 7475:. 7445:. 7415:. 7331:. 7298:. 7265:. 7237:95 7235:. 7231:. 7169:. 7106:^ 7052:. 7046:. 7021:. 7013:. 7001:. 6974:. 6968:. 6956:^ 6933:25 6931:. 6927:. 6912:^ 6890:^ 6872:. 6866:. 6848:^ 6836:. 6822:^ 6804:. 6800:. 6753:. 6743:34 6716:. 6706:. 6680:^ 6666:. 6658:. 6646:. 6630:^ 6616:. 6606:. 6594:53 6592:. 6588:. 6566:^ 6552:. 6542:. 6532:16 6530:. 6526:. 6503:. 6493:. 6479:. 6475:. 6452:. 6444:. 6434:67 6432:. 6409:. 6397:43 6395:. 6391:. 6368:. 6360:. 6348:44 6346:. 6342:. 6330:^ 6316:. 6308:. 6296:. 6284:^ 6266:. 6254:29 6252:. 6248:. 6225:. 6217:. 6207:66 6205:. 6193:^ 6179:. 6169:. 6159:72 6157:. 6153:. 6141:^ 6127:. 6117:. 6107:60 6105:. 6101:. 6089:^ 6075:. 6063:75 6061:. 6057:. 6034:. 6026:. 6016:85 6014:. 5991:. 5983:. 5969:. 5965:. 5953:^ 5939:. 5927:62 5925:. 5921:. 5898:. 5890:. 5880:78 5878:. 5855:. 5847:. 5837:80 5835:. 5812:. 5804:. 5794:68 5792:. 5768:. 5758:88 5756:. 5733:. 5725:. 5715:40 5713:. 5690:. 5678:. 5655:. 5647:. 5637:35 5635:. 5612:. 5602:. 5592:22 5590:. 5586:. 5563:. 5555:. 5543:. 5520:. 5510:11 5508:. 5485:. 5475:11 5473:. 5443:. 5435:. 5423:. 5419:. 5367:. 5355:74 5353:. 5349:. 5326:. 5316:. 5306:. 5294:. 5290:. 5267:. 5257:. 5245:30 5243:. 5239:. 5216:. 5206:. 5196:59 5194:. 5190:. 5167:. 5159:. 5147:43 5145:. 5141:. 5118:. 5110:. 5100:57 5098:. 5075:. 5065:92 5063:. 5040:. 5026:. 5022:. 4999:. 4989:. 4977:13 4975:. 4971:. 4959:^ 4945:. 4931:. 4927:. 4915:^ 4901:. 4891:. 4879:. 4875:. 4863:^ 4849:. 4839:. 4827:12 4825:. 4821:. 4798:. 4784:. 4780:. 4764:^ 4750:. 4740:. 4728:. 4724:. 4701:. 4691:. 4679:. 4675:. 4663:^ 4649:. 4641:. 4629:. 4605:. 4597:. 4585:57 4583:. 4579:. 4556:. 4542:. 4538:. 4515:. 4507:. 4495:. 4472:. 4464:. 4454:25 4452:. 4429:. 4421:. 4411:41 4409:. 4391:^ 4370:. 4362:. 4354:. 4344:79 4342:. 4338:. 4304:. 4282:. 4272:. 4260:. 4256:. 4233:. 4223:. 4213:15 4211:. 4207:. 4184:. 4174:. 4162:. 4158:. 4135:. 4125:. 4113:. 4109:. 4086:. 4076:. 4064:. 4060:. 4037:. 4023:. 4019:. 3996:. 3982:. 3978:. 3955:. 3947:. 3937:37 3935:. 3912:. 3900:18 3898:. 3894:. 3871:. 3859:. 3836:. 3826:99 3824:. 3800:. 3790:29 3788:. 3764:. 3754:97 3752:. 3739:^ 3725:. 3715:29 3713:. 3690:. 3680:. 3668:. 3664:. 3641:. 3633:. 3621:. 3597:. 3587:. 3575:12 3573:. 3569:. 3546:. 3536:. 3524:99 3522:. 3518:. 3506:^ 3485:. 3477:. 3469:. 3459:50 3457:. 3453:. 3436:^ 3422:. 3414:. 3404:70 3402:. 3385:^ 3371:. 3361:26 3359:. 3335:. 3327:. 3317:45 3315:. 3302:^ 3288:. 3276:. 3264:^ 3250:. 3238:67 3236:. 3232:. 3220:^ 3206:. 3192:. 3188:. 3165:. 3155:. 3143:13 3141:. 3137:. 3114:. 3106:. 3094:. 3070:. 3058:29 3056:. 3052:. 3029:. 3021:. 3009:. 2985:. 2973:. 2949:. 2939:. 2927:. 2923:. 2900:. 2888:. 2876:^ 2862:. 2850:. 2801:. 2791:17 2789:. 2766:. 2754:13 2752:. 2748:. 2725:. 2713:. 2689:. 2679:15 2677:. 2653:. 2641:. 2617:. 2605:. 2590:^ 2572:. 2568:. 2543:. 2517:. 2513:. 2487:. 2463:^ 2417:. 2374:. 2349:^ 2331:. 2327:. 2284:^ 2266:. 2236:. 2225:^ 2173:. 2045:, 2038:. 1918:. 1708:. 1644:. 1564:. 1530:, 1526:, 1522:, 1518:, 1514:, 1502:, 1482:, 1478:, 1474:, 1470:, 1466:, 1462:, 1450:, 1427:, 1411:. 1281:, 1277:, 1273:, 1223:, 1219:, 1108:, 1035:, 1031:, 1027:, 995:: 964:. 929:. 796:35 790:33 711:, 499:,5 495:(3 397:. 388:EU 376:US 363:UK 356:S4 350:AU 317:) 307:) 297:) 287:) 277:) 267:) 257:) 201:AU 169:US 105:ən 8638:: 8428:) 8424:/ 8386:) 8382:( 8343:) 8339:( 8170:) 8137:) 8089:) 8025:) 8017:( 7952:) 7948:( 7944:/ 7894:) 7890:( 7880:e 7873:t 7866:v 7851:. 7822:. 7807:. 7795:: 7767:. 7734:. 7699:. 7662:. 7631:. 7598:. 7551:. 7524:. 7491:. 7461:. 7431:. 7401:. 7374:. 7347:. 7317:. 7281:. 7251:. 7217:. 7185:. 7155:. 7129:. 7100:. 7064:. 7029:. 7009:: 6986:. 6950:. 6884:. 6842:. 6816:. 6786:. 6761:. 6749:: 6724:. 6702:: 6674:. 6654:: 6648:5 6624:. 6600:: 6560:. 6538:: 6511:. 6487:: 6460:. 6440:: 6417:. 6403:: 6376:. 6354:: 6324:. 6304:: 6278:. 6260:: 6233:. 6213:: 6187:. 6165:: 6135:. 6113:: 6083:. 6069:: 6042:. 6022:: 5999:. 5977:: 5947:. 5933:: 5906:. 5886:: 5863:. 5843:: 5820:. 5800:: 5776:. 5764:: 5741:. 5721:: 5698:. 5686:: 5663:. 5643:: 5620:. 5598:: 5571:. 5551:: 5528:. 5516:: 5493:. 5481:: 5458:. 5431:: 5401:. 5375:. 5361:: 5334:. 5310:: 5302:: 5296:8 5275:. 5251:: 5224:. 5202:: 5175:. 5153:: 5126:. 5106:: 5083:. 5071:: 5048:. 5034:: 5007:. 4983:: 4953:. 4939:: 4909:. 4887:: 4857:. 4833:: 4806:. 4792:: 4758:. 4736:: 4709:. 4687:: 4657:. 4637:: 4613:. 4591:: 4564:. 4550:: 4523:. 4503:: 4480:. 4460:: 4437:. 4417:: 4385:. 4350:: 4320:. 4290:. 4268:: 4262:4 4241:. 4219:: 4192:. 4170:: 4143:. 4121:: 4115:6 4094:. 4072:: 4066:9 4045:. 4031:: 4004:. 3990:: 3963:. 3943:: 3920:. 3906:: 3879:. 3867:: 3844:. 3832:: 3808:. 3796:: 3772:. 3760:: 3733:. 3721:: 3698:. 3676:: 3649:. 3629:: 3605:. 3581:: 3554:. 3530:: 3500:. 3465:: 3430:. 3410:: 3379:. 3367:: 3343:. 3323:: 3296:. 3284:: 3258:. 3244:: 3214:. 3200:: 3173:. 3149:: 3122:. 3102:: 3096:2 3078:. 3064:: 3037:. 3017:: 2993:. 2981:: 2957:. 2935:: 2908:. 2896:: 2870:. 2858:: 2834:. 2809:. 2797:: 2774:. 2760:: 2733:. 2721:: 2697:. 2685:: 2661:. 2649:: 2625:. 2613:: 2584:. 2554:. 2529:. 2499:. 2451:: 2429:. 2390:. 2343:. 2278:. 2252:. 1820:C 1801:T 1785:) 1779:( 1774:) 1770:( 1756:. 1616:C 1292:. 1098:. 1075:) 1068:) 1015:( 1007:( 834:) 811:5 808:O 805:2 802:N 799:F 793:H 787:C 733:) 729:( 717:) 501:R 497:R 449:) 445:( 409:. 390:: 378:: 365:: 352:: 327:) 203:: 130:/ 108:/ 102:t 99:æ 96:t 93:s 90:ˈ 87:ə 84:v 78:t 75:ˌ 72:ə 69:/ 20:)

Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.

Index