110:, the same ingredient that had tainted cough syrup and killed 138 Panamanians in 2006. Panamanian officials discovered that the toothpaste had come from China and initiated a global response. Also in May 2007, the same toothpaste was found in some Costa Rican stores. Fast action by the Ministry of Health, and notification through the media, prevented poisonings due to this product. This event was linked to the death sentence of a former pharmaceuticals control officer in China, as the Costa Rican newspaper
120:
the claim to be manufactured in South Africa by
Colgate-Palmolive South Africa LTD; they were 5 oz/100 ml tubes (a size which Colgate does not sell in the United States) and their packaging contained numerous misspellings on the labels. Colgate-Palmolive claimed it does not import products from South Africa into the United States or Canada and that DEG is never and was never used in any of its products anywhere in the world. These counterfeit products were found in smaller
119:
toothpaste imported from China was found to be contaminated with DEG, and several people in the eastern US reported experiencing headaches and pain after using the product. The same occurred in Spain with a false
Colgate toothpaste, which contained 6% DEG. The tainted products could be identified by
337:
A graphic story of a race against death from "elixir sulfanilamide," carried on by the Food and Drug
Administration in fifteen States from Virginia to California, a race not won until ninety-three persons had died after taking the lethal dose, was told by Secretary Wallace today in a report
177:
2018: From 2012 to 2018 massive amounts of generic versions of an entire class of angiotensin II inhibitor blood pressure medications (collectively called "sartans") were made with contaminated ingredients. Patients receiving these drugs were exposed to genotoxic and carcinogenic
655:
Federal drug regulators, in announcing
Wednesday that the mystery contaminant in heparin was an inexpensive, unapproved ingredient altered to mimic the real thing, moved closer to concluding that Americans might be the latest victims of lethal Chinese drug
84:
and infected over 10,000 patients worldwide. The manufacturers of the affected products became aware of the contamination but continued to sell it. After the contaminated products were banned in many developed countries, sales were shifted to developing
202:, points to a greater problem. Generic drug manufacturers often change the way in which prescription drug ingredients are made in order to lower costs of making them, so this kind of contamination may be more widespread and undetected in generic drugs.
605:
694:
A contaminated blood thinner from China has been found in drug supplies in 11 countries, and federal officials said Monday they had discovered a clear link between the contaminant and severe reactions now associated with 81 deaths in the United
302:
Then, two months ago, fatality knocked at its door. A new mixture of a new drug (sulfanilamide) with a new solvent (diethylene glycol), which Dr. Massengill's salesmen sold as Elixir
Sulfanilamide-Massengill, was discovered to be killing its
114:
reported on its issue of May 30. On June 4, 2007, a press release by the
Chinese Foreign Ministry cited an earlier study in China which concluded that up to 15.6% diethylene glycol in toothpaste is safe. In June 2007, counterfeit
643:
124:
stores, dollar stores, and discount stores in at least four states. In July 2007, diethylene glycol was found in counterfeit
Sensodyne toothpaste, on sale at a car boot sale in Derbyshire, England.
178:
N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) from 2012 until the drugs were recalled from the world drug market in 2018. The problem began in 2012, when the process for making
325:
720:
198:(NDEA), which cause genetic damage and cancer. This contamination was not detected until 2018. The incident, according to medicinal chemist and pharmaceutical industry blogger Dr.
814:
190:") was changed by generic drug manufacturers in favor of several cheaper and more efficient processes. These changes caused drugs made with tetrazole to be contaminated with
375:
775:
489:
413:
807:
745:
458:
China sentencia a muerte al exjefe de control de fármacos. (China sentences to death former drug control chief) La Nación, pp. 1 & 4. (May 30th 2007)
1146:
155:
668:
506:
1249:
800:
434:
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The syrupy poison, diethylene glycol, is an indispensable part of the modern world, an industrial solvent and prime ingredient in some antifreeze.
315:
717:
1098:
280:
353:
1269:
151:
2009, 84 Nigerian children were reported to have died after being given "My Pikin", a teething syrup contaminated with diethylene glycol.
682:
570:
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81:
1011:
470:
1239:
379:
259:
1274:
977:
212:
56:
217:
486:
865:
162:
399:
Bogdanich, W.; McLean, R. "Poisoned
Toothpaste in Panama Is Believed to Be From China", New York Times, May 19, 2007.
409:
253:
146:
918:
741:
1234:
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66:
were found to be contaminated by users to the detriment of subsequent users. Bacterial growth was found in all
1141:
88:
510:
1264:
1177:
1172:
487:
An
Epidemiological Study on the Health Effects of Population Using the Toothpaste with Diethylene Glycol
438:
1004:
850:
767:
1259:
1229:
1124:
882:
44:
595:
290:
158:, 753 cases of fungal infection occurred with 64 deaths due to contaminated injectable medication.
1052:
938:
706:
350:
182:, a chemical intermediate in the production of various angiotensin II inhibitor medications for
1119:
892:
191:
672:
1167:
1135:
997:
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195:
562:
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633:
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in
California found to contain dangerous bacteria and fungi, causing at least one fatality.
116:
40:
20:, the term "contamination" is used to describe harmful intrusions, such as the presence of
792:
35:
The following list encompasses notable medicine contamination and adulteration incidents.
8:
1037:
29:
17:
1093:
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860:
835:
249:
222:
128:
107:
96:
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71:
52:
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1114:
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1032:
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discovered that toothpaste sold in his country was labeled as containing
910:
718:"Contaminated medical marijuana believed to have killed cancer patient"
477:, Embassy of the People's Republic of China in Negara Brunel Darussalam
410:"China investigating toothpaste containing potentially deadly chemical"
532:"Toothpaste labeled Colgate recalled - More health news - nbcnews.com"
541:
316:"Wallace Reveals How Federal Agents Traced Elixir to Halt Fatalities"
179:
140:
67:
950:
877:
728:
536:
25:
245:
Sources of Contamination in Medicinal Products and Medical Devices
887:
707:
News.yahoo.com Nigeria child deaths from tainted syrup rise to 84
139:
manufacturers used diethylene glycol, which they believed to be
989:
840:
496:, Journal of Labour Medicine (China), vol.17, p 168-170, (2000)
187:
132:
21:
822:
742:"Valsartan: what caused the contamination? - ECA Academy"
80:
1985 Treatments for hemophilia derived from human blood
596:"From China to Panama, a Trail of Poisoned Medicine"
186:(popularly known by their common drug name suffix "
1147:Political abuse of psychiatry in the United States
634:"Heparin Find May Point to Chinese Counterfeiting"
156:New England Compounding Center meningitis outbreak
673:"U.S. Identifies Tainted Heparin in 11 Countries"
435:"U.S. checking all toothpaste imports from China"
1221:
507:"7online.com: Toothpaste recall expands 6/18/07"
667:
468:US 'Self-contradictory' over Toothpaste Scandal
628:
590:
235:
1099:Prescription drug prices in the United States
1005:
808:
154:2012: As of 2 November 2012 in the
412:. International Herald Tribune. 2007-05-22.
351:"Nose Drop Contamination In Dropper Bottles"
338:responding to Senate and House resolutions.
1012:
998:
815:
801:
241:
82:were contaminated with HIV and hepatitis C
944:List of medicine contamination incidents
373:
1250:Lists of disasters in the United States
1152:Political abuse of psychiatry in Russia
823:Combined substance use and adulteration
584:
1222:
734:
993:
796:
378:. TruTV Crime Library. Archived from
95:pain-relief capsules were laced with
55:, leading to the 1938 passage of the
51:as the solvent for the antibacterial
978:List of reagent testing color charts
765:
213:List of food contamination incidents
57:Federal Food, Drug, and Cosmetic Act
563:"Toxin found in fake UK toothpaste"
349:Gompertz, John and Michael, Paul.
289:. December 20, 1937. Archived from
218:List of foodborne illness outbreaks
13:
1270:United States health-related lists
866:List of polysubstance combinations
163:2012 Pakistan fake medicine crisis
14:
1286:
437:. CNN. 2007-05-23. Archived from
147:2008 Chinese heparin adulteration
1019:
919:Counterfeit illegal drug selling
768:"The Sartan Contamination Story"
1077:Economic and financial concerns
778:from the original on 2020-04-08
759:
748:from the original on 2020-08-08
711:
700:
685:from the original on 2008-12-11
661:
646:from the original on 2020-11-26
622:
608:from the original on 2021-03-16
573:from the original on 2009-01-15
555:
524:
499:
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461:
416:from the original on 2009-03-08
328:from the original on 2020-10-26
262:from the original on 2021-12-04
452:
427:
402:
393:
367:
343:
308:
273:
242:Bohrer, D. (2012). "Preface".
1:
1142:Political abuse of psychiatry
228:
74:solutions that were examined.
1240:Food and Drug Administration
89:1982 Chicago Tylenol murders
7:
1275:Social problems in medicine
1178:Hospital-acquired infection
1173:Hospital-acquired pneumonia
206:
10:
1291:
851:Combined drug intoxication
766:Lowe, Derek (2019-01-04).
99:, leading to seven deaths.
1196:
1160:
1107:
1076:
1025:
959:
901:
828:
248:. John Wiley & Sons.
1125:Compulsory sterilization
883:Polysubstance dependence
45:S. E. Massengill Company
1053:Unnecessary health care
939:Counterfeit medications
376:"The Tylenol Terrorist"
281:"Medicine: Post-Mortem"
1235:Pharmaceuticals policy
1120:Sluggish schizophrenia
829:Combined substance use
192:N-nitrosodimethylamine
143:, to make cough syrup.
1197:Records and histories
1168:Adverse drug reaction
1136:The Protest Psychosis
924:Clandestine chemistry
324:. November 26, 1937.
196:N-nitrosodiethylamine
78:1970s –
41:Elixir sulfanilamide
30:pharmaceutical drugs
1038:Medical malpractice
731:(February 7, 2017).
175:2012 –
18:medicinal chemistry
1265:Lists of disasters
1094:Financial toxicity
723:2020-04-07 at the
671:(April 22, 2008).
632:(March 20, 2008).
492:2008-06-13 at the
473:2009-03-06 at the
356:2020-09-19 at the
1217:
1216:
1183:Iatrogenic anemia
1130:Physician gag law
987:
986:
861:Polysubstance use
836:Active metabolite
364:(April 11, 1942).
223:Toxic cough syrup
129:Toxic cough syrup
108:diethylene glycol
97:potassium cyanide
49:diethylene glycol
1282:
1260:Medical scandals
1230:Health disasters
1161:Related concerns
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856:Drug interaction
846:Combination drug
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540:. Archived from
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293:on April 3, 2009
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169:medical cannabis
102:2007 Panamanian
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1108:Political abuse
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1089:Balance billing
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983:
974:Reagent testing
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772:In the Pipeline
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739:
735:
725:Wayback Machine
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669:Harris Gardiner
666:
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656:counterfeiting.
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594:(May 6, 2007).
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1204:Drug pollution
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678:New York Times
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639:New York Times
630:Walt Bogdanich
621:
601:New York Times
592:Walt Bogdanich
583:
569:. 2007-07-12.
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374:Rachael Bell.
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137:Pharmaceutical
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544:on 2018-04-11
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513:on 2007-07-06
512:
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104:Eduardo Arias
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64:Nose droppers
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53:sulfanilamide
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38:
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33:
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27:
23:
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1188:Hand washing
1134:
1115:Drapetomania
1084:Medical debt
1033:Iatrogenesis
1020:Medical harm
943:
903:Adulteration
873:Polypharmacy
780:. Retrieved
771:
761:
750:. Retrieved
736:
713:
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693:
687:. Retrieved
676:
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648:. Retrieved
637:
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610:. Retrieved
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575:. Retrieved
566:
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546:. Retrieved
542:the original
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515:. Retrieved
511:the original
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482:
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443:. Retrieved
439:the original
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418:. Retrieved
404:
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384:. Retrieved
380:the original
369:
345:
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330:. Retrieved
319:
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295:. Retrieved
291:the original
284:
275:
264:. Retrieved
244:
237:
184:hypertension
111:
72:neosynephrin
34:
15:
1255:Drug safety
1068:Never event
194:(NDMA) and
122:mom and pop
1224:Categories
935:Medicines
911:Drug fraud
782:2020-04-17
752:2020-04-17
689:2008-06-11
650:2008-03-20
612:2008-03-20
577:2010-05-08
548:2021-11-26
517:2009-07-20
445:2007-05-23
420:2007-05-22
386:2009-07-20
332:2009-07-20
297:2009-07-19
266:2023-01-09
229:References
200:Derek Lowe
43:incident:
180:tetrazole
141:glycerine
112:La Nación
68:ephedrine
26:pathogens
1026:Concepts
951:Impurity
878:Polypill
776:Archived
746:Archived
729:CBS News
721:Archived
683:Archived
644:Archived
606:Archived
571:Archived
567:BBC News
537:NBC News
490:Archived
471:Archived
414:Archived
354:Archived
326:Archived
260:Archived
207:See also
85:markets.
1245:Poisons
893:Synergy
888:Prodrug
695:States.
117:Colgate
93:Tylenol
929:Lacing
841:Codrug
252:
188:sartan
167:2017:
161:2012:
133:Panama
62:1942,
22:toxins
303:users
127:2007
47:used
39:1937
1208:List
362:JAMA
250:ISBN
70:and
131:in
28:in
24:or
16:In
1226::
774:.
770:.
744:.
727:,
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675:.
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1206:(
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976:(
816:e
809:t
802:v
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755:.
580:.
551:.
520:.
448:.
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389:.
269:.
59:.
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