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Loratadine

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case on the issue, prompted the administration to issue new rules for television commercials in 1997. Instead of including the "brief summary" that took up a full page in magazine ads and would take too long to explain in a short television advertisement, drug makers were allowed to refer viewers to
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Loratadine was approved by the FDA in 1993. The drug continued to be available only by prescription in the U.S. until it went off patent in 2002. It was then subsequently approved for over-the-counter sales. Once it became an unpatented over-the-counter drug, the price dropped significantly.
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said such things as "At last, a clear day is here" and "It's time for Claritin" and repeatedly told viewers "Ask your doctor ." The first ads made people aware of the brand and increased prescriptions, which led Schering-Plough and others to aggressively pursue the advertising strategy.
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derivatives (found in grapefruit) lead to increased plasma levels of loratadine — that is, more of the drug was present in the bloodstream than typical for a dose. This had clinically significant effects in controlled trials of 10 mg loratadine treatment.
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Pons-Guiraud A, Nekam K, Lahovsky J, Costa A, Piacentini A (2006). "Emedastine difumarate versus loratadine in chronic idiopathic urticaria: a randomized, double-blind, controlled European multicentre clinical trial".
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Fumagalli F, Baiardini I, Pasquali M, Compalati E, Guerra L, Massacane P, et al. (August 2004). "Antihistamines: do they work? Further well-controlled trials involving larger samples are needed".
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Hunto ST, Kim HG, Baek KS, Jeong D, Kim E, Kim JH, et al. (July 2020). "Loratadine, an antihistamine drug, exhibits anti-inflammatory activity through suppression of the NF-kB pathway".
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million in Claritin direct-to-consumer advertising in 1998 and 1999, far more than any other brand. Spending on direct-to-consumer advertising by the pharmaceutical industry rose from
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Ghosal A, Gupta S, Ramanathan R, Yuan Y, Lu X, Su AD, et al. (August 2009). "Metabolism of loratadine and further characterization of its in vitro metabolites".
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Devillier P, Roche N, Faisy C (2008). "Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review".
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unable to perform his crime-fighting duties because hay fever and antihistamines make him drowsy. After being given a prescription for Claritin, he saved Batman from
847:, and other skin allergies. For allergic rhinitis, loratadine is indicated for both nasal and eye symptoms including sneezing, runny nose, and itchy or burning eyes. 5618: 5608: 1047:
10 nM) > terfenadine > loratadine. However, the onset of action varies significantly and clinical efficacy is not always directly related to only the H
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receptor potency, as concentration of free drug at the receptor must also be considered. Loratadine also shows anti-inflammatory properties independent of H
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Kay GG, Harris AG (July 1999). "Loratadine: a non-sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation".
2257:"Antihistaminic, anti-inflammatory, and antiallergic properties of the nonsedating second-generation antihistamine desloratadine: a review of the evidence" 5603: 2068:"Evaluation of the pharmacokinetics and electrocardiographic pharmacodynamics of loratadine with concomitant administration of ketoconazole or cimetidine" 1194:(OTC) while they were still protected by patents; the administration granted the request, which was not binding on manufacturers. In the United States, 6469: 729: 7227: 6776: 6272: 5111: 671: 7484: 7167: 893:
The medication is available in many different forms, including tablets, oral suspension, and syrups. Also available are quick-dissolving tablets.
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InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
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print ads, informative telephone lines, and websites, and to urge people to talk to their doctors if they wanted additional information.
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Bielory L, Lien KW, Bigelsen S (2005). "Efficacy and tolerability of newer antihistamines in the treatment of allergic conjunctivitis".
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Affrime M, Gupta S, Banfield C, Cohen A (2002). "A pharmacokinetic profile of desloratadine in healthy adults, including elderly".
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into the urine, and a similar amount is excreted into the feces. Traces of unmetabolised loratadine can be found in the urine.
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pathway, and by regulating the release of cytokines and chemokines, thereby regulating the recruitment of inflammatory cells.
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Nelson WL (2002). "Antihistamines and related antiallergic and antiulcer agents". In Williams DH, Foye WO, Lemke TL (eds.).
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made loratadine available over the counter in 2002. By 2015, loratadine was available over the counter in many countries.
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appears to be safe but has not been well studied. It is not recommended in children less than two years old. It is in the
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In the mid-1990s, the marketing team for Claritin at Schering-Plough found a way around these rules. They created
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Ueda T, Arai S, Amoh Y, Katsuoka K (2011). "Kimura's disease treated with suplatast tosilate and loratadine".
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Common side effects include sleepiness, dry mouth, and headache. Serious side effects are rare and include
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This trend, along with advice from the Food and Drug Administration's attorneys that it could not win a
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In 2017, loratadine was available under many brand names and in many forms worldwide, including several
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The first television commercial for a prescription drug was broadcast in the United States in 1983, by
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commercials that never actually said what the drug was for, but instead showed sunny images, and the
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As a "non-sedating" antihistamine, loratadine causes less (but still significant, in some cases)
150: 52: 7741: 6504: 5864: 5493: 5322: 4269: 2644:"Schering-Plough Loses Patent Lawsuit Over Claritin, Opening Door For Cheaper Generic Versions" 1295: 870: 285: 1971:(in German) (8 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. pp. 456–461. 1570: 1151:(FDA) for approval, the agency had already approved a competitor's nonsedating antihistamine, 8071: 7898: 7792: 7746: 6631: 6499: 4984: 4961: 4778: 4760: 4529: 4432: 3574: 1068: 1017: 1005: 524: 415: 229: 5709: 5699: 1067:
Loratadine is given orally, is well absorbed from the gastrointestinal tract, and has rapid
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Ethyl 4-(8-chloro-5,6-dihydro-11H-benzocycloheptapyridin-11-ylidene)-1-piperidinecarboxylate
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In 1998, in an unprecedented action in the United States, an American insurance company,
934: 855: 370: 6043: 1012:. The potency of second generation histamine antagonists is (from strongest to weakest) 598: 575: 39: 7923: 7847: 6322: 6077: 5878: 5409: 5126: 3844: 3774: 3566: 3563: 3251: 3128: 2582: 2547: 2518: 2475: 2372: 2329: 2281: 2256: 2237: 2189: 2162: 2143: 2092: 2067: 2042: 1510:"Clarityn Allergy 10mg Tablets (P) - Summary of Product Characteristics (SmPC) - (eMC)" 808: 781: 774: 241: 124: 2747: 2704: 2679: 7982: 7690: 6556: 6474: 6027: 5734: 4979: 4330: 2709: 2625: 2621: 2510: 2467: 2463: 2432: 2395: 2364: 2360: 2333: 2321: 2286: 2229: 2225: 2194: 2135: 2131: 2097: 2083: 2046: 2015: 2005: 1972: 1915: 1884: 1841: 1818: 1755: 1719: 1576: 1170: 981: 945: 758: 86: 2522: 2479: 2376: 2241: 7736: 7695: 7332: 7297: 6312: 6032: 5914: 5844: 5729: 5719: 5633: 5483: 4456: 4323: 3939: 3799: 3719: 3523: 3471: 3173: 3015: 2995: 2699: 2691: 2617: 2502: 2459: 2424: 2356: 2313: 2276: 2268: 2221: 2184: 2174: 2147: 2127: 2087: 2079: 2038: 1997: 1874: 1810: 1604: 1207: 1191: 1163: 1140: 940:
Unlike earlier-generation antihistamines, loratadine is considered largely free of
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Thompson D, Oster G (May 1996). "Use of terfenadine and contraindicated drugs".
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Kosoglou T, Salfi M, Lim JM, Batra VK, Cayen MN, Affrime MB (December 2000).
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World Health Organization model list of essential medicines: 21st list 2019
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AlMasoud N, Bakheit AH, Alshammari MF, Abdel-Aziz HA, AlRabiah H (2022).
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Loratadine was patented in 1980 and came to market in 1988. It is on the
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Loratadine's peak effect occurs after 1–2 hours, and its biological
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The marketing of the Claritin brand is important in the history of
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Loratadine is a tricyclic antihistamine, which acts as a selective
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Association of the European Self-Medication Industry Database.
5002: 4793: 1084: 1080: 957: 535: 308: 304: 1708: 1685:"Loratadine Drug Usage Statistics, United States, 2013 - 2022" 1147:
antihistamine. By the time Schering submitted the drug to the
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receptors. The effect is exhibited through suppression of the
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was given away to advertise Claritin. The book, written by
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than the older antihistamines, because it penetrates the
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developed loratadine as part of a quest for a potential
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Antihistamines should be discontinued 48 hours prior to
1863:"Transfer of drugs and other chemicals into human milk" 805:
World Health Organization's List of Essential Medicines
2864:"Ten Years Later: Direct to Consumer Drug Advertising" 8024: 2785:"The untold story of TV's first prescription drug ad" 2065: 1483:. The American Society of Health-System Pharmacists. 1102:
is on average eight hours (range 3 to 20 hours) with
1800: 854:, loratadine attenuates the itching associated with 765:. It is also available in drug combinations such as 2677: 2211: 2117: 2113: 2111: 1373: 423: 5121: 2680:"Switching prescription drugs to over the counter" 1860: 1347: 913:). In the U.S., it is classified as category B in 3562: 2303: 8048: 2779: 2777: 2775: 2773: 2771: 2769: 2678:Cohen JP, Paquette C, Cairns CP (January 2005). 2108: 1745: 1743: 1741: 1739: 1737: 1735: 1733: 403: 1967:Mutschler E, Geisslinger G, Kroemer HK (2001). 1568: 1272:In 1998, a 12-page one-shot comic based on the 937:less. Headache is also a possible side effect. 378: 7876: 2543:"The Claritin Effect; Prescription for Profit" 2254: 693:O=C(OCC)N4CC/C(=C2/c1ccc(Cl)cc1CCc3cccnc23)CC4 8097:World Health Organization essential medicines 7660: 7646: 6418: 5391: 5105: 3548: 2896: 2766: 2603: 1730: 2486: 2340: 2297: 2248: 2205: 2160: 1962: 1960: 889:An example of a loratadine 10-mg tablet (Rx) 753:among others, is a medication used to treat 112: 5674: 5140:Tooltip Platelet-activating factor receptor 5119: 1121:, and is distantly related to the atypical 7653: 7639: 6425: 6411: 5725:Allopregnanedione (5α-dihydroprogesterone) 5398: 5384: 5112: 5098: 3555: 3541: 2903: 2889: 2536: 2534: 2532: 1475: 1473: 1471: 1469: 1467: 1465: 1463: 1461: 597: 574: 463: 38: 29: 5310: 2703: 2652:. Leiner Health Products. 5 August 2003. 2492: 2280: 2188: 2178: 2091: 1957: 1878: 1608: 1504: 1502: 956:Substances that act as inhibitors of the 483: 5423:Tooltip Constitutive androstane receptor 2910: 2673: 2671: 2392:Foye's principles of medicinal chemistry 2072:British Journal of Clinical Pharmacology 884: 811:. In the United States, it is available 338:40% as conjugated metabolites into urine 2529: 2255:Canonica GW, Blaiss M (February 2011). 1625:"Competitive Generic Therapy Approvals" 1458: 1113:In structure, it is closely related to 839:such as hay fever (allergic rhinitis), 570: 443: 85: 8049: 6178:Pregnanedione (5β-dihydroprogesterone) 5564:Pregnanedione (5β-dihydroprogesterone) 2834: 2810: 2808: 2806: 2740: 2597: 2389: 2261:The World Allergy Organization Journal 1589: 1575:. John Wiley & Sons. p. 549. 1562: 1499: 1410:"Claritin Allergy Product information" 1176: 901:Loratadine is usually compatible with 588: 235: 7976:Merck Manual of Diagnosis and Therapy 7634: 6406: 5379: 5093: 3536: 3521: 2929: 2884: 2668: 1904:"Desloratadine for allergic rhinitis" 1861:Committee on Drugs (September 2001). 1835: 1749: 1603:. Geneva: World Health Organization. 1550:from the original on 21 December 2016 1520:from the original on 20 December 2016 1487:from the original on 21 December 2016 543: 523: 248: 103: 71: 57:Claritin, Claratyne, Clarityn, others 3522: 2540: 2507:10.1046/j.1365-2222.1999.0290s3147.x 2383: 896: 861: 188: 2803: 2656:from the original on 12 August 2016 1901: 1665:from the original on 30 August 2024 1181: 1062: 992: 503: 394: 13: 8092:Drugs developed by Schering-Plough 3820:Etybenzatropine (ethylbenztropine) 2043:10.1016/B978-0-444-53717-1.00314-0 1936: 1926:from the original on 24 July 2005. 1330:billion in 1998, and by 2006, was 920: 14: 8113: 7173:Levomepromazine/Methotrimeprazine 2754:from the original on 4 March 2016 2748:"Loratadine International Brands" 2495:Clinical and Experimental Allergy 2161:Church MK, Church DS (May 2013). 1540:"Loratadine Use During Pregnancy" 1355:"Loratadine Use During Pregnancy" 1149:U.S. Food and Drug Administration 215: 135: 8034: 6792:Nortriptyline (noramitriptyline) 2986:Bromazine (bromodiphenhydramine) 2843:Batman: Claritin Allergy Special 2622:10.1001/jama.1996.03530410053033 2555:from the original on 27 May 2015 2464:10.2165/00003088-200241001-00003 2361:10.1111/j.1398-9995.2004.00573.x 2226:10.2165/00003495-200565020-00004 2163:"Pharmacology of antihistamines" 2132:10.2165/00003088-200847040-00001 2084:10.1046/j.1365-2125.2000.00290.x 1442:. 30 August 2019. Archived from 631: 628: 622: 5074:Monoamine metabolism modulators 2856: 2720: 2636: 2567: 2443: 2408: 2154: 2026: 1985: 1930: 1895: 1854: 1829: 1803:European Journal of Dermatology 1794: 1768: 1712:European Journal of Dermatology 1702: 1677: 1647: 1617: 1569:Fischer J, Ganellin CR (2006). 1169:(Clarinex/Aerius), which is an 987: 951: 880: 822: 807:. Loratadine is available as a 798:second-generation antihistamine 769:, in which it is combined with 718:Key:JCCNYMKQOSZNPW-UHFFFAOYSA-N 244:(GSL, OTC) / Pharmacy 170:Second-generation antihistamine 6432: 5730:Allopregnanolone (brexanolone) 3242:Tripelennamine (pyribenzamine) 2035:Meyler's Side Effects of Drugs 1532: 1428: 1402: 1248:direct-to-consumer advertising 948:, dry mouth, blurred vision). 911:American Academy of Pediatrics 909:- probably compatible, by the 637: 616: 224: 1: 6385:Receptor/signaling modulators 6343:Tropanyl 3,5-dimethulbenzoate 6193:Pregnenolone 16α-carbonitrile 5364:Receptor/signaling modulators 5079:Monoamine reuptake inhibitors 5069:Receptor/signaling modulators 2167:Indian Journal of Dermatology 1776:"Claritin- loratadine tablet" 1572:Analogue-based Drug Discovery 1340: 1069:first-pass hepatic metabolism 340:Similar amount into the feces 8082:Peripherally selective drugs 3116:Phenylpyridinylpropanamines: 2614:American Medical Association 2579:Food and Drug Administration 2273:10.1097/WOX.0b013e3182093e19 2002:10.1016/bs.podrm.2021.10.002 1941:. emedtv.com. Archived from 1631:Food and Drug Administration 1241: 845:chronic idiopathic urticaria 749:, sold under the brand name 7: 7959:Merck Headquarters Building 5920:Dodecylbenzenesulfonic acid 5679:Tooltip Pregnane X receptor 5407:Xenobiotic-sensing receptor 4702:Quisultazine (quisultidine) 4349:Tetracyclic antidepressants 3039:Diphenylmethanolpiperidines 2737:Page accessed 11 April 2015 1275:Batman: The Animated Series 324:8 hours, active metabolite 10: 8118: 7058:Carfenazine (carphenazine) 3665:Benzatropine (benztropine) 2429:10.2174/187231209789352067 2037:. 2016. pp. 606–618. 1131: 867:Loratadine/pseudoephedrine 767:loratadine/pseudoephedrine 606:Chemical and physical data 7967: 7951: 7765: 7729: 7668: 7472: 7449: 7391: 7018: 6870: 6787:Northiaden (nordosulepin) 6525:Tricyclic antidepressants 6518: 6440: 6376: 5672: 5416: 5355: 5303: 5173: 5147: 5133: 5061: 5016: 4972: 4960: 4830: 4771: 4759: 4594: 4540: 4528: 4379:Tricyclic antidepressants 4235:Sequifenadine (bicarphen) 3629: 3585: 3573: 3530: 3450: 3420: 3250: 3197: 3057:Diphenylmethylpiperazines 2983:Diarylmethoxyalkylamines: 2973: 2923: 2816:"DTC: The first 10 years" 2728:Loratadine OTC regulation 2541:Hall SS (11 March 2001). 2452:Clinical Pharmacokinetics 2318:10.1016/j.bcp.2020.113949 2120:Clinical Pharmacokinetics 1908:American Family Physician 1597:World Health Organization 1309:Schering-Plough invested 1201: 1115:tricyclic antidepressants 726: 701: 681: 659: 646: 610: 605: 586: 554: 534: 514: 494: 474: 454: 434: 414: 389: 369: 349: 344: 332: 315: 294: 284: 274: 266: 205: 200: 175: 163: 149: 123: 93: 79: 61: 51: 46: 37: 28: 8062:Benzocycloheptapyridines 6930:Hydroxyethylpromethazine 6303:Testosterone isocaproate 6218:Reverse triiodothyronine 4017:Second/third-generation: 3850:Hydroxyethylpromethazine 3329:Hydroxyethylpromethazine 2306:Biochemical Pharmacology 2180:10.4103/0019-5154.110832 877:, a nasal decongestant. 16:Antihistamine medication 8077:H1 receptor antagonists 7416:Eslicarbazepine acetate 6622:Depramine (balipramine) 5695:17α-Hydroxyprogesterone 5690:17α-Hydroxypregnenolone 5226:Ginkgolide B (BN-52021) 4657:Lavoltidine (loxtidine) 4270:Atypical antipsychotics 4215:Quifenadine (phencarol) 3880:Mepyramine (pyrilamine) 3640:4-Methyldiphenhydramine 3502:Mepyramine (pyrilamine) 3222:Mepyramine (pyrilamine) 2733:8 December 2015 at the 2696:10.1136/bmj.330.7481.39 2417:Drug Metabolism Letters 1902:See S (November 2003). 1071:; it is metabolized by 931:psychomotor retardation 819:million prescriptions. 259:OTC / Rx-only 7742:Cubist Pharmaceuticals 7318:Savoxepin/Cipazoxapine 6505:Pyridinobenzodiazepine 4433:Typical antipsychotics 1939:"Claritin and Alcohol" 1880:10.1542/peds.108.3.776 1108:conjugated metabolites 890: 871:fixed dose combination 800:family of medication. 777:. It is taken orally. 7899:Ezetimibe/simvastatin 7793:Ezetimibe/simvastatin 7747:H. K. Mulford Company 7662:Merck & Co., Inc. 6652:Dosulepin (dothiepin) 6637:Desmethyltrimipramine 6632:Desmethylclomipramine 6627:(desmethylimipramine) 6500:Pyridazinobenzoxazine 5434:6,7-Dimethylesculetin 4399:dosulepin (dothiepin) 1969:Arzneimittelwirkungen 1836:Jasek W, ed. (2007). 1815:10.1684/ejd.2011.1539 1750:Jasek W, ed. (2007). 1655:"The Top 300 of 2022" 888: 6021:Hypericum perforatum 6010:Hetacillin potassium 3261:Dibenzocycloheptenes 1514:www.medicines.org.uk 7669:Corporate directors 6465:Dibenzocycloheptene 5850:Cyproterone acetate 5750:Amlodipine besylate 3780:Dexchlorpheniramine 3593:2-Pyridylethylamine 3139:Dexchlorpheniramine 2585:on 23 February 2008 2501:(Suppl 3): 147–50. 1323:million in 1995 to 1177:Society and culture 935:blood/brain barrier 25: 8057:1988 introductions 7924:Rocuronium bromide 7848:rVSV-ZEBOV vaccine 6323:Thonzonium bromide 6078:Methylprednisolone 5879:prasterone sulfate 3845:Homochlorcyclizine 3775:Dexbrompheniramine 3564:Histamine receptor 3129:Dexbrompheniramine 2791:. 11 December 2015 2548:The New York Times 2355:(Suppl 78): 74–7. 2033:"Antihistamines". 1782:. 10 February 2020 1516:. 7 October 2015. 1361:. 10 February 2020 1210:formulations with 1079:system, including 1023:0.4 nM) > 982:skin allergy tests 891: 809:generic medication 782:allergic reactions 775:nasal decongestant 242:General sales list 21: 8022: 8021: 7983:The Merck Manuals 7947: 7946: 7628: 7627: 6557:Amitriptylinoxide 6475:Dibenzothiazepine 6400: 6399: 6394: 6393: 6028:Indinavir sulfate 5735:Alpha-Lipoic acid 5710:Δ-Androstenedione 5700:Δ-Androstenedione 5373: 5372: 5351: 5350: 5299: 5298: 5087: 5086: 5057: 5056: 4985:α-Methylhistamine 4980:4-Methylhistamine 4956: 4955: 4779:α-Methylhistamine 4755: 4754: 4524: 4523: 4473:Unknown/unsorted: 4331:hydroxynefazodone 3637:First-generation: 3515: 3514: 3428:Phenylpiperazines 2458:(Suppl 1): 13–9. 2401:978-0-683-30737-5 2052:978-0-444-53716-4 2011:978-0-323-85482-5 1978:978-3-8047-1763-3 1761:978-3-85200-181-4 1171:active metabolite 1091:. Its metabolite 946:urinary retention 897:Contraindications 873:of the drug with 862:Combination drugs 759:allergic rhinitis 744: 743: 672:Interactive image 556:CompTox Dashboard 252: 239: 227: 219: 139: 106: 8109: 8102:Ethoxy compounds 8039: 8038: 8037: 8030: 7874: 7873: 7737:Acceleron Pharma 7696:Rochelle Lazarus 7686:William Harrison 7655: 7648: 7641: 7632: 7631: 7451:Anticholinergics 7333:Thiethylperazine 7298:Prochlorperazine 6529: 6470:Dibenzodiazepine 6427: 6420: 6413: 6404: 6403: 6313:Thiamylal sodium 6048:γ-linolenic acid 6044:α-Linolenic acid 6042:Linolenic acid: 6033:Lasalocid sodium 6023:(St John's wort) 5915:Docusate calcium 5845:Cyclophosphamide 5720:Allopregnanediol 5705:Δ-Androstenediol 5680: 5676: 5634:Ethinylestradiol 5484:Cyclophosphamide 5424: 5420: 5400: 5393: 5386: 5377: 5376: 5308: 5307: 5145: 5144: 5141: 5137: 5123: 5114: 5107: 5100: 5091: 5090: 4997: 4970: 4969: 4811: 4769: 4768: 4580: 4538: 4537: 4457:prochlorperazine 4324:Phenylpiperazine 3940:Phenyltoloxamine 3800:Diphenylpyraline 3720:Chlorphenoxamine 3615: 3583: 3582: 3557: 3550: 3543: 3534: 3533: 3524:Pharmacodynamics 3519: 3518: 3472:Chlorphenoxamine 3199:Ethylenediamines 3174:Phenyltoloxamine 3133:+pseudoephedrine 3016:Diphenylpyraline 2996:Chlorphenoxamine 2933: 2931: 2905: 2898: 2891: 2882: 2881: 2875: 2874: 2872: 2870: 2860: 2854: 2853: 2852: 2850: 2838: 2832: 2831: 2829: 2827: 2812: 2801: 2800: 2798: 2796: 2781: 2764: 2763: 2761: 2759: 2744: 2738: 2724: 2718: 2717: 2707: 2675: 2666: 2665: 2663: 2661: 2640: 2634: 2633: 2601: 2595: 2594: 2592: 2590: 2581:. Archived from 2571: 2565: 2564: 2562: 2560: 2538: 2527: 2526: 2490: 2484: 2483: 2447: 2441: 2440: 2412: 2406: 2405: 2387: 2381: 2380: 2344: 2338: 2337: 2301: 2295: 2294: 2284: 2252: 2246: 2245: 2209: 2203: 2202: 2192: 2182: 2158: 2152: 2151: 2115: 2106: 2105: 2095: 2063: 2057: 2056: 2030: 2024: 2023: 1989: 1983: 1982: 1964: 1955: 1954: 1952: 1950: 1945:on 24 April 2012 1934: 1928: 1927: 1899: 1893: 1892: 1882: 1858: 1852: 1851: 1833: 1827: 1826: 1798: 1792: 1791: 1789: 1787: 1772: 1766: 1765: 1747: 1728: 1727: 1706: 1700: 1699: 1697: 1695: 1681: 1675: 1674: 1672: 1670: 1651: 1645: 1644: 1642: 1640: 1621: 1615: 1614: 1612: 1593: 1587: 1586: 1566: 1560: 1559: 1557: 1555: 1536: 1530: 1529: 1527: 1525: 1506: 1497: 1496: 1494: 1492: 1477: 1456: 1455: 1453: 1451: 1446:on 10 April 2020 1432: 1426: 1425: 1423: 1421: 1406: 1400: 1399: 1397: 1395: 1385:nctr-crs.fda.gov 1377: 1371: 1370: 1368: 1366: 1351: 1336: 1333: 1329: 1326: 1322: 1319: 1315: 1312: 1208:combination drug 1192:over the counter 1182:Over the counter 1141:blockbuster drug 1063:Pharmacokinetics 1039:6 nM) > 1031:3 nM) > 993:Pharmacodynamics 856:Kimura's disease 818: 813:over the counter 761:(hay fever) and 757:. This includes 740: 739: 732: 674: 654: 639: 633: 630: 624: 618: 601: 590: 579: 578: 564: 562: 547: 527: 507: 487: 467: 447: 427: 407: 397: 396: 382: 320: 257: 250: 247: 237: 234: 226: 223: 217: 214: 192: 137: 134: 116: 105: 102: 89: 75: 42: 33: 26: 24: 20: 8117: 8116: 8112: 8111: 8110: 8108: 8107: 8106: 8047: 8046: 8045: 8035: 8033: 8025: 8023: 8018: 7963: 7943: 7884:Coppertone sign 7877:Schering-Plough 7872: 7761: 7752:Schering-Plough 7725: 7664: 7659: 7629: 7624: 7515:Cyclobenzaprine 7468: 7445: 7411:Eslicarbazepine 7393:Anticonvulsants 7387: 7368:Triflupromazine 7363:Trifluoperazine 7228:Octomethothepin 7073:Chlorprothixene 7014: 6935:Isopromethazine 6866: 6777:Norbutriptyline 6527: 6522: 6520:Antidepressants 6514: 6485:Dibenzoxazepine 6436: 6431: 6401: 6396: 6395: 6390: 6372: 6273:Suberoylanilide 5990:Fluorometholone 5885:Dibunate sodium 5765:Aurothioglucose 5678: 5668: 5604:3,17β-Estradiol 5422: 5412: 5404: 5374: 5369: 5347: 5295: 5169: 5139: 5129: 5118: 5088: 5083: 5053: 5012: 4995: 4965: 4952: 4826: 4809: 4764: 4751: 4590: 4578: 4533: 4520: 4327:antidepressants 3860:Isopromethazine 3795:Diphenhydramine 3680:Brompheniramine 3625: 3613: 3578: 3569: 3561: 3526: 3516: 3511: 3487:Diphenhydramine 3446: 3432:Antidepressants 3416: 3364:Antidepressants 3266:Antidepressants 3246: 3193: 3119:Brompheniramine 3006:Diphenhydramine 2969: 2927: 2919: 2909: 2879: 2878: 2868: 2866: 2862: 2861: 2857: 2848: 2846: 2840: 2839: 2835: 2825: 2823: 2814: 2813: 2804: 2794: 2792: 2783: 2782: 2767: 2757: 2755: 2746: 2745: 2741: 2735:Wayback Machine 2725: 2721: 2690:(7481): 39–41. 2676: 2669: 2659: 2657: 2642: 2641: 2637: 2602: 2598: 2588: 2586: 2573: 2572: 2568: 2558: 2556: 2539: 2530: 2491: 2487: 2448: 2444: 2413: 2409: 2402: 2388: 2384: 2345: 2341: 2302: 2298: 2253: 2249: 2210: 2206: 2159: 2155: 2116: 2109: 2064: 2060: 2053: 2032: 2031: 2027: 2012: 1990: 1986: 1979: 1965: 1958: 1948: 1946: 1935: 1931: 1900: 1896: 1859: 1855: 1848: 1834: 1830: 1799: 1795: 1785: 1783: 1774: 1773: 1769: 1762: 1748: 1731: 1707: 1703: 1693: 1691: 1683: 1682: 1678: 1668: 1666: 1653: 1652: 1648: 1638: 1636: 1623: 1622: 1618: 1594: 1590: 1583: 1567: 1563: 1553: 1551: 1538: 1537: 1533: 1523: 1521: 1508: 1507: 1500: 1490: 1488: 1479: 1478: 1459: 1449: 1447: 1434: 1433: 1429: 1419: 1417: 1416:. 25 April 2012 1408: 1407: 1403: 1393: 1391: 1379: 1378: 1374: 1364: 1362: 1353: 1352: 1348: 1343: 1334: 1331: 1327: 1324: 1320: 1317: 1313: 1310: 1303:First Amendment 1286:, and inked by 1262:brand awareness 1244: 1212:pseudoephedrine 1204: 1196:Schering-Plough 1184: 1179: 1173:of loratadine. 1137:Schering-Plough 1134: 1089:plasma proteins 1077:cytochrome P450 1065: 1054: 1050: 1046: 1038: 1030: 1021: 1009: 999:inverse agonist 995: 990: 960:enzyme such as 954: 923: 921:Adverse effects 899: 883: 875:pseudoephedrine 864: 825: 816: 771:pseudoephedrine 735: 733: 730:(what is this?) 727: 722: 719: 714: 709: 708: 697: 694: 689: 688: 677: 652: 642: 636: 627: 621: 582: 558: 550: 530: 510: 490: 470: 450: 430: 410: 393: 385: 365: 362: 357: 356: 339: 318: 286:Protein binding 276:Bioavailability 268:Pharmacokinetic 262: 255: 196: 152: 145: 126: 119: 17: 12: 11: 5: 8115: 8105: 8104: 8099: 8094: 8089: 8084: 8079: 8074: 8069: 8064: 8059: 8044: 8043: 8020: 8019: 8017: 8016: 8015: 8014: 8007: 8000: 7993: 7979: 7971: 7969: 7965: 7964: 7962: 7961: 7955: 7953: 7949: 7948: 7945: 7944: 7942: 7941: 7939:Urofollitropin 7936: 7931: 7926: 7921: 7916: 7911: 7906: 7901: 7896: 7891: 7886: 7880: 7878: 7871: 7870: 7865: 7860: 7855: 7850: 7845: 7840: 7835: 7830: 7825: 7820: 7815: 7810: 7805: 7800: 7795: 7790: 7785: 7780: 7775: 7769: 7767: 7763: 7762: 7760: 7759: 7754: 7749: 7744: 7739: 7733: 7731: 7727: 7726: 7724: 7723: 7718: 7713: 7708: 7703: 7698: 7693: 7691:William Kelley 7688: 7683: 7681:Johnnetta Cole 7678: 7672: 7670: 7666: 7665: 7658: 7657: 7650: 7643: 7635: 7626: 7625: 7623: 7622: 7617: 7612: 7607: 7602: 7597: 7592: 7587: 7582: 7577: 7572: 7567: 7562: 7557: 7552: 7547: 7542: 7540:Methylene blue 7537: 7532: 7527: 7522: 7517: 7512: 7507: 7502: 7497: 7492: 7487: 7485:Aminopromazine 7482: 7476: 7474: 7470: 7469: 7467: 7466: 7461: 7455: 7453: 7447: 7446: 7444: 7443: 7438: 7433: 7428: 7423: 7418: 7413: 7408: 7403: 7397: 7395: 7389: 7388: 7386: 7385: 7383:Zuclopenthixol 7380: 7375: 7370: 7365: 7360: 7355: 7350: 7345: 7340: 7335: 7330: 7325: 7320: 7315: 7310: 7305: 7300: 7295: 7290: 7285: 7283:Piperacetazine 7280: 7275: 7270: 7265: 7260: 7255: 7250: 7245: 7240: 7235: 7230: 7225: 7220: 7215: 7210: 7205: 7200: 7195: 7190: 7185: 7180: 7175: 7170: 7168:Isofloxythepin 7165: 7160: 7155: 7150: 7145: 7140: 7135: 7130: 7125: 7120: 7115: 7110: 7105: 7100: 7095: 7090: 7085: 7080: 7075: 7070: 7068:Chlorpromazine 7065: 7060: 7055: 7050: 7045: 7040: 7035: 7030: 7028:Acetophenazine 7024: 7022: 7020:Antipsychotics 7016: 7015: 7013: 7012: 7007: 7002: 6997: 6992: 6987: 6982: 6977: 6972: 6967: 6962: 6957: 6952: 6947: 6942: 6937: 6932: 6927: 6922: 6917: 6912: 6907: 6902: 6897: 6895:Cyproheptadine 6892: 6887: 6882: 6876: 6874: 6872:Antihistamines 6868: 6867: 6865: 6864: 6859: 6854: 6849: 6844: 6839: 6834: 6829: 6824: 6819: 6814: 6809: 6804: 6799: 6794: 6789: 6784: 6779: 6774: 6769: 6764: 6759: 6754: 6749: 6744: 6739: 6734: 6729: 6724: 6719: 6714: 6709: 6704: 6699: 6694: 6692:Imipraminoxide 6689: 6684: 6679: 6674: 6669: 6664: 6659: 6654: 6649: 6644: 6639: 6634: 6629: 6624: 6619: 6614: 6612:Cyanodothiepin 6609: 6604: 6599: 6594: 6589: 6584: 6579: 6574: 6569: 6564: 6559: 6554: 6549: 6544: 6539: 6533: 6531: 6516: 6515: 6513: 6512: 6507: 6502: 6497: 6492: 6487: 6482: 6480:Dibenzothiepin 6477: 6472: 6467: 6462: 6457: 6452: 6446: 6444: 6438: 6437: 6430: 6429: 6422: 6415: 6407: 6398: 6397: 6392: 6391: 6389: 6388: 6381: 6377: 6374: 6373: 6371: 6370: 6365: 6356: 6355: 6350: 6345: 6340: 6338:Troleandomycin 6335: 6330: 6325: 6320: 6315: 6310: 6305: 6300: 6295: 6290: 6285: 6280: 6275: 6270: 6265: 6260: 6258:Spironolactone 6255: 6250: 6245: 6240: 6235: 6230: 6225: 6220: 6215: 6210: 6205: 6200: 6195: 6190: 6185: 6180: 6175: 6170: 6165: 6160: 6155: 6150: 6145: 6140: 6135: 6130: 6128:Norelgestromin 6125: 6120: 6115: 6110: 6105: 6100: 6095: 6090: 6085: 6080: 6075: 6070: 6065: 6060: 6055: 6050: 6040: 6035: 6030: 6025: 6017: 6012: 6007: 6002: 5997: 5992: 5987: 5985:Flucloxacillin 5982: 5977: 5972: 5967: 5962: 5957: 5952: 5947: 5942: 5937: 5932: 5927: 5922: 5917: 5912: 5907: 5902: 5897: 5892: 5887: 5882: 5872: 5862: 5857: 5852: 5847: 5842: 5840:Corticosterone 5837: 5832: 5827: 5822: 5817: 5812: 5807: 5805:Chlorpromazine 5802: 5797: 5792: 5787: 5782: 5777: 5772: 5767: 5762: 5757: 5752: 5747: 5742: 5737: 5732: 5727: 5722: 5717: 5712: 5707: 5702: 5697: 5692: 5683: 5681: 5670: 5669: 5667: 5666: 5661: 5656: 5651: 5646: 5641: 5636: 5631: 5626: 5624:17-Androstanol 5621: 5619:3β-Androstanol 5616: 5614:3α-Androstenol 5611: 5609:3α-Androstanol 5606: 5597: 5596: 5591: 5586: 5581: 5576: 5571: 5566: 5561: 5556: 5551: 5546: 5541: 5536: 5531: 5526: 5521: 5516: 5511: 5506: 5501: 5491: 5486: 5481: 5476: 5471: 5466: 5464:Chlorpromazine 5461: 5456: 5451: 5446: 5441: 5436: 5427: 5425: 5414: 5413: 5403: 5402: 5395: 5388: 5380: 5371: 5370: 5368: 5367: 5360: 5356: 5353: 5352: 5349: 5348: 5346: 5345: 5340: 5335: 5330: 5328:Phosphocholine 5325: 5320: 5314: 5312: 5305: 5301: 5300: 5297: 5296: 5294: 5293: 5288: 5283: 5278: 5273: 5268: 5263: 5258: 5253: 5248: 5243: 5238: 5233: 5228: 5223: 5218: 5213: 5208: 5203: 5198: 5193: 5188: 5183: 5177: 5175: 5171: 5170: 5168: 5167: 5162: 5157: 5151: 5149: 5142: 5131: 5130: 5117: 5116: 5109: 5102: 5094: 5085: 5084: 5082: 5081: 5076: 5071: 5066: 5062: 5059: 5058: 5055: 5054: 5052: 5051: 5046: 5041: 5036: 5031: 5026: 5020: 5018: 5014: 5013: 5011: 5010: 5005: 5000: 4992: 4987: 4982: 4976: 4974: 4967: 4963: 4958: 4957: 4954: 4953: 4951: 4950: 4945: 4940: 4935: 4930: 4925: 4920: 4915: 4910: 4908:Iodophenpropit 4905: 4900: 4895: 4890: 4885: 4880: 4875: 4870: 4865: 4860: 4855: 4850: 4845: 4840: 4834: 4832: 4828: 4827: 4825: 4824: 4819: 4814: 4806: 4801: 4796: 4791: 4786: 4781: 4775: 4773: 4766: 4762: 4757: 4756: 4753: 4752: 4750: 4749: 4744: 4739: 4734: 4729: 4724: 4719: 4714: 4709: 4704: 4699: 4694: 4689: 4684: 4679: 4674: 4669: 4664: 4659: 4654: 4649: 4644: 4639: 4634: 4629: 4624: 4619: 4614: 4609: 4604: 4598: 4596: 4592: 4591: 4589: 4588: 4583: 4575: 4570: 4565: 4560: 4555: 4550: 4544: 4542: 4535: 4531: 4526: 4525: 4522: 4521: 4519: 4518: 4513: 4508: 4503: 4498: 4493: 4488: 4483: 4478: 4469: 4468: 4437:chlorpromazine 4430: 4376: 4346: 4321: 4263: 4262: 4257: 4252: 4247: 4242: 4237: 4232: 4227: 4222: 4217: 4212: 4207: 4202: 4197: 4192: 4187: 4182: 4177: 4172: 4167: 4162: 4157: 4152: 4150:Levocetirizine 4147: 4142: 4137: 4132: 4127: 4122: 4117: 4112: 4107: 4102: 4097: 4092: 4090:Clobenztropine 4087: 4082: 4077: 4072: 4067: 4062: 4057: 4052: 4047: 4042: 4037: 4032: 4027: 4022: 4013: 4012: 4007: 4005:Tripelennamine 4002: 3997: 3992: 3987: 3982: 3977: 3972: 3967: 3962: 3957: 3952: 3947: 3942: 3937: 3932: 3927: 3922: 3917: 3912: 3907: 3902: 3897: 3892: 3887: 3882: 3877: 3872: 3867: 3862: 3857: 3852: 3847: 3842: 3840:Histapyrrodine 3837: 3832: 3827: 3822: 3817: 3812: 3807: 3802: 3797: 3792: 3787: 3785:Dimenhydrinate 3782: 3777: 3772: 3767: 3762: 3757: 3755:Cyproheptadine 3752: 3747: 3742: 3737: 3732: 3727: 3722: 3717: 3715:Chlorphenamine 3712: 3707: 3705:Chloropyramine 3702: 3700:Chlorcyclizine 3697: 3692: 3687: 3682: 3677: 3672: 3667: 3662: 3657: 3652: 3647: 3642: 3633: 3631: 3627: 3626: 3624: 3623: 3618: 3610: 3605: 3600: 3595: 3589: 3587: 3580: 3576: 3571: 3570: 3560: 3559: 3552: 3545: 3537: 3531: 3528: 3527: 3513: 3512: 3510: 3509: 3504: 3499: 3494: 3489: 3484: 3479: 3474: 3469: 3467:Chloropyramine 3464: 3458: 3456: 3448: 3447: 3445: 3444: 3439: 3424: 3422: 3418: 3417: 3415: 3414: 3409: 3404: 3399: 3394: 3389: 3384: 3379: 3357: 3356: 3351: 3346: 3341: 3336: 3331: 3326: 3321: 3314:Phenothiazines 3309: 3308: 3303: 3298: 3293: 3288: 3283: 3281:Cyproheptadine 3278: 3273: 3256: 3254: 3248: 3247: 3245: 3244: 3239: 3234: 3229: 3224: 3219: 3217:Histapyrrodine 3214: 3212:Chloropyramine 3209: 3203: 3201: 3195: 3194: 3192: 3191: 3186: 3181: 3176: 3171: 3166: 3161: 3152: 3151: 3146: 3143:+betamethasone 3136: 3126: 3124:Chlorphenamine 3121: 3112: 3111: 3106: 3101: 3096: 3091: 3086: 3081: 3079:Chlorcyclizine 3076: 3075: 3074: 3072:Levocetirizine 3064: 3052: 3051: 3046: 3034: 3033: 3028: 3023: 3018: 3013: 3003: 2998: 2993: 2988: 2979: 2977: 2975:Diarylmethanes 2971: 2970: 2968: 2967: 2962: 2957: 2952: 2947: 2942: 2936: 2934: 2925:Benzimidazoles 2921: 2920: 2912:Antihistamines 2908: 2907: 2900: 2893: 2885: 2877: 2876: 2855: 2833: 2822:. 1 April 2007 2802: 2765: 2739: 2719: 2667: 2635: 2596: 2566: 2528: 2485: 2442: 2407: 2400: 2382: 2339: 2296: 2247: 2204: 2153: 2107: 2058: 2051: 2025: 2010: 1984: 1977: 1956: 1929: 1914:(10): 2015–6. 1894: 1853: 1846: 1828: 1793: 1767: 1760: 1729: 1701: 1676: 1646: 1635:. 3 March 2023 1616: 1588: 1581: 1561: 1531: 1498: 1457: 1427: 1401: 1372: 1345: 1344: 1342: 1339: 1282:, penciled by 1243: 1240: 1203: 1200: 1183: 1180: 1178: 1175: 1162:Schering also 1133: 1130: 1064: 1061: 1052: 1048: 1044: 1036: 1028: 1025:levocetirizine 1019: 1007: 1001:of peripheral 994: 991: 989: 986: 974:furanocoumarin 953: 950: 942:antimuscarinic 922: 919: 898: 895: 882: 879: 863: 860: 827:Loratadine is 824: 821: 790:liver problems 742: 741: 724: 723: 721: 720: 717: 715: 712: 704: 703: 702: 699: 698: 696: 695: 692: 684: 683: 682: 679: 678: 676: 675: 667: 665: 657: 656: 650: 644: 643: 640: 634: 625: 619: 614: 608: 607: 603: 602: 592: 584: 583: 581: 580: 567: 565: 552: 551: 549: 548: 540: 538: 532: 531: 529: 528: 520: 518: 512: 511: 509: 508: 500: 498: 492: 491: 489: 488: 480: 478: 472: 471: 469: 468: 460: 458: 452: 451: 449: 448: 440: 438: 432: 431: 429: 428: 420: 418: 412: 411: 409: 408: 400: 398: 387: 386: 384: 383: 375: 373: 367: 366: 364: 363: 360: 352: 351: 350: 347: 346: 342: 341: 336: 330: 329: 322: 313: 312: 298: 292: 291: 288: 282: 281: 278: 272: 271: 264: 263: 261: 260: 245: 232: 221: 211: 209: 203: 202: 198: 197: 195: 194: 181: 179: 173: 172: 167: 161: 160: 155: 153:administration 147: 146: 144: 143: 141: 131: 129: 121: 120: 118: 117: 99: 97: 91: 90: 83: 77: 76: 69: 59: 58: 55: 49: 48: 44: 43: 35: 34: 15: 9: 6: 4: 3: 2: 8114: 8103: 8100: 8098: 8095: 8093: 8090: 8088: 8085: 8083: 8080: 8078: 8075: 8073: 8070: 8068: 8065: 8063: 8060: 8058: 8055: 8054: 8052: 8042: 8032: 8031: 8028: 8013: 8012: 8008: 8006: 8005: 8001: 7999: 7998: 7994: 7992: 7991: 7987: 7986: 7985: 7984: 7980: 7978: 7977: 7973: 7972: 7970: 7966: 7960: 7957: 7956: 7954: 7950: 7940: 7937: 7935: 7932: 7930: 7927: 7925: 7922: 7920: 7917: 7915: 7912: 7910: 7907: 7905: 7902: 7900: 7897: 7895: 7892: 7890: 7889:Desloratadine 7887: 7885: 7882: 7881: 7879: 7875: 7869: 7866: 7864: 7861: 7859: 7856: 7854: 7851: 7849: 7846: 7844: 7841: 7839: 7836: 7834: 7831: 7829: 7826: 7824: 7821: 7819: 7816: 7814: 7811: 7809: 7806: 7804: 7803:Fosaprepitant 7801: 7799: 7796: 7794: 7791: 7789: 7786: 7784: 7781: 7779: 7776: 7774: 7771: 7770: 7768: 7764: 7758: 7755: 7753: 7750: 7748: 7745: 7743: 7740: 7738: 7735: 7734: 7732: 7728: 7722: 7721:Peter Wendell 7719: 7717: 7716:Wendell Weeks 7714: 7712: 7709: 7707: 7704: 7702: 7699: 7697: 7694: 7692: 7689: 7687: 7684: 7682: 7679: 7677: 7676:Richard Clark 7674: 7673: 7671: 7667: 7663: 7656: 7651: 7649: 7644: 7642: 7637: 7636: 7633: 7621: 7618: 7616: 7613: 7611: 7608: 7606: 7603: 7601: 7598: 7596: 7593: 7591: 7588: 7586: 7583: 7581: 7578: 7576: 7573: 7571: 7568: 7566: 7563: 7561: 7558: 7556: 7553: 7551: 7548: 7546: 7543: 7541: 7538: 7536: 7533: 7531: 7528: 7526: 7523: 7521: 7518: 7516: 7513: 7511: 7508: 7506: 7503: 7501: 7498: 7496: 7493: 7491: 7488: 7486: 7483: 7481: 7478: 7477: 7475: 7471: 7465: 7462: 7460: 7457: 7456: 7454: 7452: 7448: 7442: 7439: 7437: 7436:Oxitriptyline 7434: 7432: 7431:Oxcarbazepine 7429: 7427: 7426:Licarbazepine 7424: 7422: 7419: 7417: 7414: 7412: 7409: 7407: 7404: 7402: 7401:Carbamazepine 7399: 7398: 7396: 7394: 7390: 7384: 7381: 7379: 7376: 7374: 7371: 7369: 7366: 7364: 7361: 7359: 7356: 7354: 7351: 7349: 7346: 7344: 7341: 7339: 7338:Thiopropazate 7336: 7334: 7331: 7329: 7326: 7324: 7323:Sulforidazine 7321: 7319: 7316: 7314: 7311: 7309: 7306: 7304: 7301: 7299: 7296: 7294: 7291: 7289: 7286: 7284: 7281: 7279: 7276: 7274: 7271: 7269: 7266: 7264: 7261: 7259: 7256: 7254: 7253:Peradithiepin 7251: 7249: 7246: 7244: 7241: 7239: 7236: 7234: 7231: 7229: 7226: 7224: 7221: 7219: 7216: 7214: 7211: 7209: 7206: 7204: 7201: 7199: 7196: 7194: 7193:Meperathiepin 7191: 7189: 7186: 7184: 7181: 7179: 7176: 7174: 7171: 7169: 7166: 7164: 7161: 7159: 7156: 7154: 7151: 7149: 7146: 7144: 7141: 7139: 7136: 7134: 7131: 7129: 7126: 7124: 7123:Docloxythepin 7121: 7119: 7116: 7114: 7111: 7109: 7106: 7104: 7101: 7099: 7096: 7094: 7091: 7089: 7086: 7084: 7081: 7079: 7076: 7074: 7071: 7069: 7066: 7064: 7061: 7059: 7056: 7054: 7051: 7049: 7046: 7044: 7041: 7039: 7036: 7034: 7031: 7029: 7026: 7025: 7023: 7021: 7017: 7011: 7008: 7006: 7003: 7001: 6998: 6996: 6993: 6991: 6988: 6986: 6983: 6981: 6978: 6976: 6973: 6971: 6968: 6966: 6963: 6961: 6958: 6956: 6953: 6951: 6948: 6946: 6943: 6941: 6938: 6936: 6933: 6931: 6928: 6926: 6923: 6921: 6918: 6916: 6913: 6911: 6910:Desloratadine 6908: 6906: 6903: 6901: 6898: 6896: 6893: 6891: 6888: 6886: 6883: 6881: 6878: 6877: 6875: 6873: 6869: 6863: 6860: 6858: 6855: 6853: 6850: 6848: 6845: 6843: 6840: 6838: 6835: 6833: 6830: 6828: 6827:Protriptyline 6825: 6823: 6820: 6818: 6815: 6813: 6810: 6808: 6805: 6803: 6800: 6798: 6795: 6793: 6790: 6788: 6785: 6783: 6780: 6778: 6775: 6773: 6772:Nitroxazepine 6770: 6768: 6767:Monometacrine 6765: 6763: 6760: 6758: 6755: 6753: 6750: 6748: 6745: 6743: 6740: 6738: 6735: 6733: 6730: 6728: 6725: 6723: 6720: 6718: 6715: 6713: 6710: 6708: 6705: 6703: 6700: 6698: 6695: 6693: 6690: 6688: 6685: 6683: 6680: 6678: 6675: 6673: 6670: 6668: 6665: 6663: 6660: 6658: 6655: 6653: 6650: 6648: 6645: 6643: 6640: 6638: 6635: 6633: 6630: 6628: 6625: 6623: 6620: 6618: 6617:Demexiptiline 6615: 6613: 6610: 6608: 6605: 6603: 6600: 6598: 6595: 6593: 6590: 6588: 6585: 6583: 6580: 6578: 6575: 6573: 6570: 6568: 6565: 6563: 6560: 6558: 6555: 6553: 6552:Amitriptyline 6550: 6548: 6545: 6543: 6540: 6538: 6535: 6534: 6532: 6526: 6521: 6517: 6511: 6508: 6506: 6503: 6501: 6498: 6496: 6495:Phenothiazine 6493: 6491: 6488: 6486: 6483: 6481: 6478: 6476: 6473: 6471: 6468: 6466: 6463: 6461: 6460:Dibenzazepine 6458: 6456: 6453: 6451: 6448: 6447: 6445: 6443: 6439: 6435: 6428: 6423: 6421: 6416: 6414: 6409: 6408: 6405: 6387: 6386: 6382: 6379: 6378: 6375: 6369: 6366: 6364: 6361: 6358: 6357: 6354: 6351: 6349: 6346: 6344: 6341: 6339: 6336: 6334: 6331: 6329: 6326: 6324: 6321: 6319: 6316: 6314: 6311: 6309: 6306: 6304: 6301: 6299: 6296: 6294: 6291: 6289: 6286: 6284: 6281: 6279: 6278:Sulfisoxazole 6276: 6274: 6271: 6269: 6266: 6264: 6261: 6259: 6256: 6254: 6251: 6249: 6246: 6244: 6241: 6239: 6236: 6234: 6231: 6229: 6226: 6224: 6221: 6219: 6216: 6214: 6211: 6209: 6206: 6204: 6201: 6199: 6196: 6194: 6191: 6189: 6186: 6184: 6181: 6179: 6176: 6174: 6171: 6169: 6166: 6164: 6161: 6159: 6156: 6154: 6153:Phenobarbital 6151: 6149: 6146: 6144: 6141: 6139: 6136: 6134: 6131: 6129: 6126: 6124: 6121: 6119: 6116: 6114: 6111: 6109: 6106: 6104: 6101: 6099: 6096: 6094: 6091: 6089: 6086: 6084: 6081: 6079: 6076: 6074: 6071: 6069: 6066: 6064: 6061: 6059: 6056: 6054: 6051: 6049: 6045: 6041: 6039: 6038:Levothyroxine 6036: 6034: 6031: 6029: 6026: 6024: 6022: 6018: 6016: 6013: 6011: 6008: 6006: 6003: 6001: 6000:Guggulsterone 5998: 5996: 5993: 5991: 5988: 5986: 5983: 5981: 5978: 5976: 5973: 5971: 5968: 5966: 5963: 5961: 5958: 5956: 5953: 5951: 5948: 5946: 5943: 5941: 5938: 5936: 5933: 5931: 5928: 5926: 5923: 5921: 5918: 5916: 5913: 5911: 5908: 5906: 5903: 5901: 5898: 5896: 5895:Dicloxacillin 5893: 5891: 5888: 5886: 5883: 5880: 5876: 5873: 5870: 5866: 5863: 5861: 5860:Dexamethasone 5858: 5856: 5853: 5851: 5848: 5846: 5843: 5841: 5838: 5836: 5833: 5831: 5828: 5826: 5823: 5821: 5818: 5816: 5813: 5811: 5808: 5806: 5803: 5801: 5798: 5796: 5795:Cephaloridine 5793: 5791: 5788: 5786: 5783: 5781: 5778: 5776: 5773: 5771: 5768: 5766: 5763: 5761: 5758: 5756: 5753: 5751: 5748: 5746: 5743: 5741: 5738: 5736: 5733: 5731: 5728: 5726: 5723: 5721: 5718: 5716: 5713: 5711: 5708: 5706: 5703: 5701: 5698: 5696: 5693: 5691: 5688: 5685: 5684: 5682: 5677: 5671: 5665: 5662: 5660: 5657: 5655: 5652: 5650: 5647: 5645: 5642: 5640: 5637: 5635: 5632: 5630: 5627: 5625: 5622: 5620: 5617: 5615: 5612: 5610: 5607: 5605: 5602: 5599: 5598: 5595: 5594:Valproic acid 5592: 5590: 5587: 5585: 5582: 5580: 5577: 5575: 5572: 5570: 5567: 5565: 5562: 5560: 5557: 5555: 5554:Phenobarbital 5552: 5550: 5547: 5545: 5542: 5540: 5537: 5535: 5532: 5530: 5527: 5525: 5522: 5520: 5517: 5515: 5512: 5510: 5507: 5505: 5502: 5499: 5495: 5492: 5490: 5487: 5485: 5482: 5480: 5477: 5475: 5472: 5470: 5467: 5465: 5462: 5460: 5457: 5455: 5454:Carbamazepine 5452: 5450: 5447: 5445: 5442: 5440: 5437: 5435: 5432: 5429: 5428: 5426: 5421: 5415: 5411: 5408: 5401: 5396: 5394: 5389: 5387: 5382: 5381: 5378: 5366: 5365: 5361: 5358: 5357: 5354: 5344: 5341: 5339: 5336: 5334: 5331: 5329: 5326: 5324: 5321: 5319: 5316: 5315: 5313: 5309: 5306: 5302: 5292: 5289: 5287: 5284: 5282: 5279: 5277: 5274: 5272: 5269: 5267: 5264: 5262: 5259: 5257: 5254: 5252: 5249: 5247: 5244: 5242: 5239: 5237: 5234: 5232: 5229: 5227: 5224: 5222: 5219: 5217: 5214: 5212: 5209: 5207: 5204: 5202: 5199: 5197: 5194: 5192: 5189: 5187: 5184: 5182: 5179: 5178: 5176: 5172: 5166: 5163: 5161: 5158: 5156: 5153: 5152: 5150: 5146: 5143: 5138: 5132: 5128: 5125: 5115: 5110: 5108: 5103: 5101: 5096: 5095: 5092: 5080: 5077: 5075: 5072: 5070: 5067: 5064: 5063: 5060: 5050: 5047: 5045: 5042: 5040: 5037: 5035: 5032: 5030: 5027: 5025: 5022: 5021: 5019: 5015: 5009: 5006: 5004: 5001: 4999: 4993: 4991: 4988: 4986: 4983: 4981: 4978: 4977: 4975: 4971: 4968: 4966: 4959: 4949: 4946: 4944: 4941: 4939: 4936: 4934: 4931: 4929: 4926: 4924: 4921: 4919: 4916: 4914: 4911: 4909: 4906: 4904: 4901: 4899: 4896: 4894: 4891: 4889: 4886: 4884: 4881: 4879: 4876: 4874: 4871: 4869: 4866: 4864: 4861: 4859: 4856: 4854: 4851: 4849: 4846: 4844: 4841: 4839: 4836: 4835: 4833: 4829: 4823: 4820: 4818: 4815: 4813: 4807: 4805: 4802: 4800: 4797: 4795: 4792: 4790: 4787: 4785: 4782: 4780: 4777: 4776: 4774: 4770: 4767: 4765: 4758: 4748: 4745: 4743: 4740: 4738: 4735: 4733: 4730: 4728: 4725: 4723: 4720: 4718: 4715: 4713: 4710: 4708: 4705: 4703: 4700: 4698: 4695: 4693: 4690: 4688: 4685: 4683: 4680: 4678: 4675: 4673: 4670: 4668: 4665: 4663: 4660: 4658: 4655: 4653: 4650: 4648: 4645: 4643: 4640: 4638: 4635: 4633: 4630: 4628: 4625: 4623: 4620: 4618: 4615: 4613: 4610: 4608: 4605: 4603: 4600: 4599: 4597: 4593: 4587: 4584: 4582: 4576: 4574: 4571: 4569: 4566: 4564: 4561: 4559: 4556: 4554: 4551: 4549: 4546: 4545: 4543: 4539: 4536: 4534: 4527: 4517: 4514: 4512: 4509: 4507: 4504: 4502: 4499: 4497: 4494: 4492: 4489: 4487: 4484: 4482: 4479: 4477: 4474: 4471: 4470: 4466: 4462: 4458: 4454: 4450: 4446: 4442: 4438: 4434: 4431: 4428: 4424: 4423:protriptyline 4420: 4419:nortriptyline 4416: 4412: 4408: 4404: 4400: 4396: 4392: 4388: 4384: 4383:amitriptyline 4380: 4377: 4374: 4370: 4366: 4362: 4358: 4354: 4350: 4347: 4344: 4343:triazoledione 4340: 4336: 4332: 4328: 4325: 4322: 4319: 4315: 4311: 4307: 4303: 4299: 4295: 4291: 4287: 4286:brilaroxazine 4283: 4282:brexpiprazole 4279: 4275: 4271: 4268: 4265: 4264: 4261: 4258: 4256: 4253: 4251: 4248: 4246: 4243: 4241: 4238: 4236: 4233: 4231: 4228: 4226: 4223: 4221: 4218: 4216: 4213: 4211: 4208: 4206: 4203: 4201: 4198: 4196: 4193: 4191: 4188: 4186: 4183: 4181: 4178: 4176: 4173: 4171: 4168: 4166: 4163: 4161: 4158: 4156: 4153: 4151: 4148: 4146: 4145:Levocabastine 4143: 4141: 4138: 4136: 4133: 4131: 4128: 4126: 4123: 4121: 4118: 4116: 4113: 4111: 4108: 4106: 4103: 4101: 4098: 4096: 4095:Desloratadine 4093: 4091: 4088: 4086: 4083: 4081: 4078: 4076: 4073: 4071: 4068: 4066: 4063: 4061: 4058: 4056: 4053: 4051: 4048: 4046: 4043: 4041: 4038: 4036: 4033: 4031: 4028: 4026: 4023: 4021: 4018: 4015: 4014: 4011: 4008: 4006: 4003: 4001: 3998: 3996: 3993: 3991: 3988: 3986: 3985:Thenyldiamine 3983: 3981: 3978: 3976: 3973: 3971: 3970:Pyrrobutamine 3968: 3966: 3963: 3961: 3958: 3956: 3953: 3951: 3948: 3946: 3943: 3941: 3938: 3936: 3933: 3931: 3928: 3926: 3923: 3921: 3918: 3916: 3913: 3911: 3908: 3906: 3903: 3901: 3898: 3896: 3895:Methapyrilene 3893: 3891: 3890:Methafurylene 3888: 3886: 3883: 3881: 3878: 3876: 3873: 3871: 3868: 3866: 3863: 3861: 3858: 3856: 3853: 3851: 3848: 3846: 3843: 3841: 3838: 3836: 3833: 3831: 3828: 3826: 3823: 3821: 3818: 3816: 3813: 3811: 3808: 3806: 3803: 3801: 3798: 3796: 3793: 3791: 3788: 3786: 3783: 3781: 3778: 3776: 3773: 3771: 3768: 3766: 3763: 3761: 3758: 3756: 3753: 3751: 3748: 3746: 3743: 3741: 3738: 3736: 3733: 3731: 3728: 3726: 3723: 3721: 3718: 3716: 3713: 3711: 3708: 3706: 3703: 3701: 3698: 3696: 3695:Carbinoxamine 3693: 3691: 3688: 3686: 3683: 3681: 3678: 3676: 3673: 3671: 3668: 3666: 3663: 3661: 3658: 3656: 3653: 3651: 3648: 3646: 3643: 3641: 3638: 3635: 3634: 3632: 3628: 3622: 3619: 3617: 3611: 3609: 3606: 3604: 3601: 3599: 3596: 3594: 3591: 3590: 3588: 3584: 3581: 3579: 3572: 3568: 3565: 3558: 3553: 3551: 3546: 3544: 3539: 3538: 3535: 3529: 3525: 3520: 3508: 3505: 3503: 3500: 3498: 3495: 3493: 3490: 3488: 3485: 3483: 3480: 3478: 3475: 3473: 3470: 3468: 3465: 3463: 3460: 3459: 3457: 3454: 3449: 3443: 3442:Phenbenzamine 3440: 3437: 3433: 3429: 3426: 3425: 3423: 3419: 3413: 3410: 3408: 3405: 3403: 3400: 3398: 3395: 3393: 3390: 3388: 3385: 3383: 3380: 3377: 3373: 3369: 3365: 3362: 3359: 3358: 3355: 3352: 3350: 3347: 3345: 3342: 3340: 3337: 3335: 3332: 3330: 3327: 3325: 3322: 3320: 3316: 3315: 3311: 3310: 3307: 3304: 3302: 3299: 3297: 3294: 3292: 3291:Desloratadine 3289: 3287: 3284: 3282: 3279: 3277: 3274: 3271: 3270:amitriptyline 3267: 3263: 3262: 3258: 3257: 3255: 3253: 3249: 3243: 3240: 3238: 3235: 3233: 3232:Phenbenzamine 3230: 3228: 3227:Methapyrilene 3225: 3223: 3220: 3218: 3215: 3213: 3210: 3208: 3205: 3204: 3202: 3200: 3196: 3190: 3187: 3185: 3182: 3180: 3179:Pyrrobutamine 3177: 3175: 3172: 3170: 3167: 3165: 3162: 3160: 3157: 3154: 3153: 3150: 3147: 3144: 3140: 3137: 3134: 3130: 3127: 3125: 3122: 3120: 3117: 3114: 3113: 3110: 3107: 3105: 3102: 3100: 3097: 3095: 3092: 3090: 3087: 3085: 3082: 3080: 3077: 3073: 3070: 3069: 3068: 3065: 3063: 3059: 3058: 3054: 3053: 3050: 3047: 3045: 3041: 3040: 3036: 3035: 3032: 3029: 3027: 3024: 3022: 3019: 3017: 3014: 3011: 3007: 3004: 3002: 2999: 2997: 2994: 2992: 2991:Carbinoxamine 2989: 2987: 2984: 2981: 2980: 2978: 2976: 2972: 2966: 2963: 2961: 2958: 2956: 2953: 2951: 2948: 2946: 2943: 2941: 2938: 2937: 2935: 2926: 2922: 2917: 2913: 2906: 2901: 2899: 2894: 2892: 2887: 2886: 2883: 2865: 2859: 2845: 2844: 2837: 2821: 2817: 2811: 2809: 2807: 2790: 2786: 2780: 2778: 2776: 2774: 2772: 2770: 2753: 2750:. Drugs.com. 2749: 2743: 2736: 2732: 2729: 2723: 2715: 2711: 2706: 2701: 2697: 2693: 2689: 2685: 2681: 2674: 2672: 2655: 2651: 2650: 2645: 2639: 2631: 2627: 2623: 2619: 2615: 2611: 2607: 2600: 2584: 2580: 2576: 2570: 2554: 2550: 2549: 2544: 2537: 2535: 2533: 2524: 2520: 2516: 2512: 2508: 2504: 2500: 2496: 2489: 2481: 2477: 2473: 2469: 2465: 2461: 2457: 2453: 2446: 2438: 2434: 2430: 2426: 2423:(3): 162–70. 2422: 2418: 2411: 2403: 2397: 2393: 2386: 2378: 2374: 2370: 2366: 2362: 2358: 2354: 2350: 2343: 2335: 2331: 2327: 2323: 2319: 2315: 2311: 2307: 2300: 2292: 2288: 2283: 2278: 2274: 2270: 2266: 2262: 2258: 2251: 2243: 2239: 2235: 2231: 2227: 2223: 2220:(2): 215–28. 2219: 2215: 2208: 2200: 2196: 2191: 2186: 2181: 2176: 2173:(3): 219–24. 2172: 2168: 2164: 2157: 2149: 2145: 2141: 2137: 2133: 2129: 2126:(4): 217–30. 2125: 2121: 2114: 2112: 2103: 2099: 2094: 2089: 2085: 2081: 2077: 2073: 2069: 2062: 2054: 2048: 2044: 2040: 2036: 2029: 2021: 2017: 2013: 2007: 2003: 1999: 1995: 1988: 1980: 1974: 1970: 1963: 1961: 1944: 1940: 1933: 1925: 1921: 1917: 1913: 1909: 1905: 1898: 1890: 1886: 1881: 1876: 1873:(3): 776–89. 1872: 1868: 1864: 1857: 1849: 1847:9783852001814 1843: 1839: 1838:Austria-Codex 1832: 1824: 1820: 1816: 1812: 1809:(6): 1020–1. 1808: 1804: 1797: 1781: 1777: 1771: 1763: 1757: 1753: 1752:Austria-Codex 1746: 1744: 1742: 1740: 1738: 1736: 1734: 1725: 1721: 1718:(6): 649–54. 1717: 1713: 1705: 1690: 1686: 1680: 1664: 1660: 1656: 1650: 1634: 1632: 1626: 1620: 1611: 1606: 1602: 1598: 1592: 1584: 1582:9783527607495 1578: 1574: 1573: 1565: 1549: 1545: 1544:www.drugs.com 1541: 1535: 1519: 1515: 1511: 1505: 1503: 1486: 1482: 1476: 1474: 1472: 1470: 1468: 1466: 1464: 1462: 1445: 1441: 1437: 1431: 1415: 1414:Health Canada 1411: 1405: 1390: 1386: 1382: 1376: 1360: 1356: 1350: 1346: 1338: 1307: 1304: 1299: 1297: 1293: 1289: 1285: 1281: 1277: 1276: 1270: 1267: 1263: 1258: 1256: 1251: 1249: 1239: 1237: 1236:dexamethasone 1233: 1232:phenylephrine 1229: 1225: 1221: 1220:betamethasone 1217: 1213: 1209: 1199: 1197: 1193: 1189: 1174: 1172: 1168: 1167:desloratadine 1165: 1160: 1156: 1154: 1150: 1146: 1142: 1138: 1129: 1127: 1124: 1123:antipsychotic 1120: 1116: 1111: 1109: 1105: 1104:desloratadine 1101: 1096: 1094: 1093:desloratadine 1090: 1086: 1082: 1078: 1074: 1070: 1060: 1058: 1042: 1034: 1026: 1022: 1015: 1014:desloratadine 1011: 1004: 1000: 985: 983: 978: 975: 971: 967: 963: 959: 949: 947: 943: 938: 936: 932: 928: 918: 916: 912: 908: 904: 903:breastfeeding 894: 887: 878: 876: 872: 868: 859: 857: 853: 850:Similarly to 848: 846: 842: 838: 834: 830: 820: 814: 810: 806: 801: 799: 795: 792:. Use during 791: 787: 783: 778: 776: 772: 768: 764: 760: 756: 752: 748: 738: 731: 725: 716: 711: 710: 707: 700: 691: 690: 687: 680: 673: 669: 668: 666: 663: 658: 651: 649: 645: 615: 613: 609: 604: 600: 596: 593: 591: 589:ECHA InfoCard 585: 577: 573: 572:DTXSID2023224 569: 568: 566: 557: 553: 546: 542: 541: 539: 537: 533: 526: 522: 521: 519: 517: 513: 506: 502: 501: 499: 497: 493: 486: 482: 481: 479: 477: 473: 466: 462: 461: 459: 457: 453: 446: 442: 441: 439: 437: 433: 426: 422: 421: 419: 417: 413: 406: 402: 401: 399: 392: 388: 381: 377: 376: 374: 372: 368: 359: 358: 355: 348: 343: 337: 335: 331: 327: 326:desloratadine 323: 321: 314: 310: 306: 302: 299: 297: 293: 289: 287: 283: 279: 277: 273: 269: 265: 258: 246: 243: 233: 231: 222: 213: 212: 210: 208: 204: 199: 191: 186: 183: 182: 180: 178: 174: 171: 168: 166: 162: 159: 156: 154: 148: 142: 133: 132: 130: 128: 122: 115: 110: 101: 100: 98: 96: 92: 88: 84: 82: 78: 74: 70: 68: 64: 60: 56: 54: 50: 47:Clinical data 45: 41: 36: 32: 27: 19: 8072:Chloroarenes 8010: 8003: 7996: 7989: 7981: 7974: 7968:Publications 7929:Temozolomide 7913: 7828:Omarigliptin 7730:Subsidiaries 7711:Samuel Thier 7706:Anne Tatlock 7701:Thomas Shenk 7605:Siltenzepine 7500:Benzoctamine 7441:Rispenzepine 7373:Trifluthepin 7343:Thioridazine 7308:Prothipendyl 7268:Perphenazine 7243:Oxyprothepin 7238:Oxyclothepin 7198:Mesoridazine 7163:Homopipramol 7153:Fluphenazine 7088:Clocapramine 7063:Carpipramine 7053:Butaperazine 7010:Thiazinamium 7000:Propiomazine 6995:Promethazine 6985:Phenindamine 6970:Methdilazine 6954: 6950:Latrepirdine 6940:Isothipendyl 6862:Trimipramine 6857:Tienopramine 6832:Quinupramine 6802:Octriptyline 6697:Intriptyline 6682:Homopipramol 6607:Cotriptyline 6602:Clomipramine 6587:Cianopramine 6582:Butriptyline 6510:Thioxanthene 6490:Dibenzoxepin 6383: 6363:Ketoconazole 6360:Antagonists: 6359: 6333:Troglitazone 6308:Tetracycline 6263:Spiroxatrine 6208:Quingestrone 6203:Progesterone 6188:Pregnenolone 6183:Pregnanolone 6173:Pregnanediol 6168:Prednisolone 6093:Mifepristone 6057: 6020: 5995:Griseofulvin 5975:Fenbendazole 5960:Famprofazone 5955:Erythromycin 5950:Epothilone B 5935:Eburnamonine 5830:Clotrimazole 5820:Clofenvinfos 5755:Antimycotics 5686: 5649:Okadaic acid 5601:Antagonists: 5600: 5589:Troglitazone 5524:Mifepristone 5519:Methoxychlor 5514:Griseofulvin 5509:Ellagic acid 5489:Cypermethrin 5479:Clotrimazole 5430: 5362: 5250: 5039:Thioperamide 4943:Thioperamide 4883:Clobenpropit 4804:Immethridine 4707:Ramixotidine 4677:Niperotidine 4642:Isolamtidine 4602:Bisfentidine 4511:Trelnarizine 4491:Flotrenizine 4472: 4461:thioridazine 4453:perphenazine 4445:fluphenazine 4441:flupenthixol 4427:trimipramine 4391:clomipramine 4387:butriptyline 4373:oxaprotiline 4302:paliperidone 4274:aripiprazole 4266: 4210:Piclopastine 4159: 4140:Latrepirdine 4130:Flezelastine 4125:Fexofenadine 4110:Efletirizine 4016: 4010:Triprolidine 4000:Tolpropamine 3995:Thonzylamine 3990:Thiazinamium 3965:Propiomazine 3960:Promethazine 3930:Phenindamine 3910:Orphenadrine 3900:Methdilazine 3865:Isothipendyl 3815:Etodroxizine 3745:Cloperastine 3636: 3507:Promethazine 3497:Isothipendyl 3427: 3407:Phenindamine 3387:Latrepirdine 3376:trimipramine 3360: 3354:Promethazine 3344:Methdilazine 3334:Isothipendyl 3312: 3300: 3259: 3189:Triprolidine 3155: 3115: 3094:Etodroxizine 3055: 3044:Fexofenadine 3037: 3031:Orphenadrine 2982: 2867:. Retrieved 2858: 2847:, retrieved 2842: 2836: 2824:. Retrieved 2819: 2793:. Retrieved 2788: 2756:. Retrieved 2742: 2722: 2687: 2683: 2658:. Retrieved 2647: 2638: 2609: 2605: 2599: 2587:. Retrieved 2583:the original 2569: 2557:. Retrieved 2546: 2498: 2494: 2488: 2455: 2451: 2445: 2420: 2416: 2410: 2391: 2385: 2352: 2348: 2342: 2309: 2305: 2299: 2267:(2): 47–53. 2264: 2260: 2250: 2217: 2213: 2207: 2170: 2166: 2156: 2123: 2119: 2078:(6): 581–9. 2075: 2071: 2061: 2034: 2028: 1993: 1987: 1968: 1947:. Retrieved 1943:the original 1932: 1911: 1907: 1897: 1870: 1866: 1856: 1837: 1831: 1806: 1802: 1796: 1784:. Retrieved 1779: 1770: 1751: 1715: 1711: 1704: 1692:. Retrieved 1688: 1679: 1667:. Retrieved 1658: 1649: 1637:. Retrieved 1628: 1619: 1610:10665/325771 1600: 1591: 1571: 1564: 1552:. Retrieved 1543: 1534: 1522:. Retrieved 1513: 1489:. Retrieved 1481:"Loratadine" 1448:. Retrieved 1444:the original 1439: 1430: 1418:. Retrieved 1413: 1404: 1392:. Retrieved 1384: 1375: 1363:. Retrieved 1358: 1349: 1308: 1300: 1288:Mike DeCarlo 1273: 1271: 1259: 1252: 1245: 1205: 1185: 1161: 1157: 1135: 1112: 1097: 1066: 1041:fexofenadine 996: 988:Pharmacology 979: 966:erythromycin 962:ketoconazole 955: 952:Interactions 939: 924: 907:category L-2 905:(classified 900: 892: 881:Dosage forms 865: 849: 826: 823:Medical uses 802: 779: 750: 746: 745: 734:   728:   317:Elimination 207:Legal status 201:Legal status 95:License data 18: 8087:Piperidines 7904:Famciclovir 7858:Sitagliptin 7853:Simvastatin 7838:Rizatriptan 7833:Raltegravir 7823:Montelukast 7798:Finasteride 7773:Alendronate 7620:Zolenzepine 7610:Telenzepine 7580:Pirenzepine 7565:Pipazethate 7550:Nuvenzepine 7535:Fluradoline 7525:Darenzepine 7464:Tropatepine 7459:Profenamine 7406:Dizocilpine 7358:Traboxopine 7348:Thiothixene 7288:Pipotiazine 7273:Periciazine 7258:Perathiepin 7218:Mosapramine 7158:Gevotroline 7148:Flupentixol 7138:Flumezapine 7118:Doclothepin 7113:Cyanothepin 7098:Clorotepine 7033:Alimemazine 6990:Pimethixene 6980:Oxomemazine 6975:Olopatadine 6965:Mequitazine 6960:Mebhydrolin 6925:Fenethazine 6920:Etymemazine 6890:Clobenzepam 6822:Propizepine 6817:Pirandamine 6797:Noxiptiline 6762:Mirtazapine 6752:Metapramine 6737:Mariptiline 6732:Maprotiline 6717:Lofepramine 6707:Ketipramine 6662:Enprazepine 6647:Dimetacrine 6592:Ciclazindol 6348:Zafirlukast 6318:Thiothixene 6298:Terconazole 6248:Simvastatin 6123:Nisoldipine 6118:Nilvadipine 6103:Nicardipine 6073:Metacycline 5900:Dimercaprol 5855:Demecolcine 5815:Clindamycin 5810:Ciglitazone 5760:Artemisinin 5740:Ambrisentan 5644:Nigramide J 5579:Telmisartan 5539:Nicardipine 5449:Benfuracarb 5444:Artemisinin 5281:Terfenadine 5236:Kadsurenone 5174:Antagonists 5024:JNJ-7777120 5017:Antagonists 4928:PF-03654746 4923:NNC 38-1049 4918:JNJ-5207852 4903:Impentamine 4868:Betahistine 4831:Antagonists 4784:Cipralisant 4747:Zolantidine 4737:Venritidine 4672:Mifentidine 4617:Dalcotidine 4595:Antagonists 4573:Impromidine 4501:Napactadine 4465:thiothixene 4415:lofepramine 4395:desipramine 4369:mirtazapine 4361:maprotiline 4314:ziprasidone 4310:risperidone 4294:iloperidone 4250:Terfenadine 4245:Temelastine 4195:Olopatadine 4185:Noberastine 4175:Mizolastine 4170:Mebhydrolin 4165:Mapinastine 4155:Linetastine 4070:Carebastine 4055:Bepotastine 4040:Bamirastine 4020:Acrivastine 3980:Thenalidine 3945:Pimethixene 3935:Pheniramine 3920:Oxomemazine 3885:Mequitazine 3875:Medrylamine 3855:Hydroxyzine 3835:Flunarizine 3830:Fenethazine 3825:Etymemazine 3790:Dimetindene 3765:Decloxizine 3740:Clocinizine 3735:Clobenzepam 3725:Cinnarizine 3670:Bepotastine 3645:Alimemazine 3630:Antagonists 3598:Betahistine 3482:Dimetindene 3412:Pimethixene 3397:Olopatadine 3392:Mebhydrolin 3372:mirtazapine 3349:Oxomemazine 3339:Mequitazine 3324:Fenethazine 3319:Alimemazine 3237:Thenalidine 3184:Quifenadine 3169:Dimetindene 3159:Acrivastine 3149:Pheniramine 3099:Hydroxyzine 3084:Cinnarizine 3049:Terfenadine 2960:Mizolastine 2758:19 February 2616:: 1339–41. 2589:11 November 1554:13 December 1524:13 December 1216:paracetamol 1188:Anthem Inc. 1153:terfenadine 1145:nonsedating 833:symptomatic 655: g·mol 595:100.120.122 345:Identifiers 280:almost 100% 81:MedlinePlus 53:Trade names 8067:Carbamates 8051:Categories 8011:Geriatrics 8004:Veterinary 7952:Facilities 7919:Mometasone 7914:Loratadine 7909:Infliximab 7868:Vorinostat 7863:Vericiguat 7818:Lovastatin 7778:Aprepitant 7757:Viralytics 7600:Serazapine 7590:Pitrazepin 7575:Pinadoline 7530:Elanzepine 7520:Damotepine 7505:Carvedilol 7353:Tilozepine 7328:Tenilapine 7313:Quetiapine 7293:Piquindone 7248:Pentiapine 7233:Olanzapine 7208:Metitepine 7183:Lurasidone 7143:Fluotracen 7133:Flucindole 7103:Clotiapine 7083:Citatepine 7078:Ciclindole 7048:Butaclamol 7005:Rupatadine 6955:Loratadine 6915:Epinastine 6905:Deptropine 6900:Dacemazine 6852:Tianeptine 6847:Tampramine 6837:Spiroxepin 6812:Pipofezine 6782:Nordoxepin 6747:Melitracen 6687:Imipramine 6672:Fluotracen 6667:Fantridone 6642:Dibenzepin 6577:Batelapine 6572:Azepindole 6567:Aptazapine 6547:Amineptine 6455:Anthracene 6434:Tricyclics 6328:Tianeptine 6293:Tenylidone 6288:Tacrolimus 6233:Rimexolone 6223:Rifampicin 6163:Plicamycin 6148:Paclitaxel 6133:Omeprazole 6113:Nifedipine 6088:Mevastatin 6083:Metyrapone 6063:Lovastatin 6058:Loratadine 6015:Hyperforin 6005:Haloprogin 5970:Felodipine 5945:Enzacamene 5925:Dronabinol 5890:Diclazuril 5869:prasterone 5825:Chloroxine 5800:Cephradine 5770:Bile acids 5584:Tolnaftate 5549:Permethrin 5534:Nevirapine 5529:Nefazodone 5498:prasterone 5459:Carvedilol 5439:Amiodarone 5410:modulators 5311:Precursors 5276:SRI 63-441 5261:Rupatadine 5251:Loratadine 5246:Lexipafant 5231:Israpafant 5206:Cetirizine 5160:Edelfosine 5127:modulators 5044:Toreforant 5034:Seliforant 4998:-Histidine 4933:Pitolisant 4913:Irdabisant 4898:GSK-189254 4878:Ciproxifan 4873:Burimamide 4817:Methimepip 4812:-Histidine 4732:Tuvatidine 4722:Sufotidine 4717:Roxatidine 4712:Ranitidine 4697:Pibutidine 4692:Oxmetidine 4682:Nizatidine 4662:Lupitidine 4647:Lafutidine 4637:Famotidine 4632:Etintidine 4627:Ebrotidine 4622:Donetidine 4612:Cimetidine 4607:Burimamide 4581:-Histidine 4506:Tagorizine 4496:GSK1004723 4486:Elbanizine 4481:Belarizine 4407:imipramine 4335:nefazodone 4306:quetiapine 4298:olanzapine 4255:Vapitadine 4225:Rupatadine 4205:Pibaxizine 4160:Loratadine 4120:Epinastine 4115:Emedastine 4080:Clemastine 4075:Cetirizine 4065:Cabastinen 4050:Bepiastine 4045:Barmastine 4035:Azelastine 4030:Astemizole 4025:Alinastine 3955:Pipoxizine 3805:Doxylamine 3770:Deptropine 3760:Dacemazine 3730:Clemastine 3710:Chlorothen 3690:Captodiame 3650:Antazoline 3616:-Histidine 3567:modulators 3477:Clemastine 3382:Epinastine 3306:Rupatadine 3301:Loratadine 3286:Deptropine 3252:Tricyclics 3207:Antazoline 3067:Cetirizine 3021:Doxylamine 3001:Clemastine 2955:Emedastine 2945:Azelastine 2940:Astemizole 2869:26 October 2849:6 December 2826:26 October 2795:26 October 2649:PRNewswire 2312:: 113949. 1994:Loratadine 1937:Monson K. 1867:Pediatrics 1491:8 December 1394:22 October 1341:References 1296:Poison Ivy 1284:Joe Staton 1250:of drugs. 1228:salbutamol 1126:quetiapine 1119:imipramine 1117:, such as 1073:isoenzymes 1033:cetirizine 970:cimetidine 852:cetirizine 835:relief of 747:Loratadine 660:3D model ( 648:Molar mass 525:CHEBI:6538 485:7AJO3BO7QN 456:ChemSpider 416:IUPHAR/BPS 380:79794-75-5 371:CAS Number 354:IUPAC name 311:-mediated) 296:Metabolism 165:Drug class 114:Loratadine 23:Loratadine 7894:Ezetimibe 7843:Rofecoxib 7808:Indinavir 7788:Ezetimibe 7783:Ertapenem 7615:Tipindole 7595:Pizotifen 7560:Perlapine 7555:Oxetorone 7545:Monatepil 7510:Cidoxepin 7495:Beloxepin 7490:Atiprosin 7480:Adosopine 7421:Etazepine 7303:Promazine 7278:Pinoxepin 7213:Metoxepin 7203:Metiapine 7188:Maroxepin 7128:Erizepine 7108:Clozapine 7093:Clomacran 7043:Asenapine 7038:Amoxapine 6945:Ketotifen 6885:Bisulepin 6880:Azatadine 6842:Tandamine 6807:Opipramol 6722:Losindole 6702:Iprindole 6677:Hepzidine 6597:Cidoxepin 6562:Amoxapine 6542:Amezepine 6537:Amoxapine 6253:Sirolimus 6243:Ritonavir 6238:Riodipine 6228:Rifaximin 6213:Reserpine 6198:Proadifen 6143:Oxatomide 6098:Nafcillin 6068:Meclizine 5930:Droxidopa 5910:Docetaxel 5835:Colforsin 5785:Bumecaine 5775:Bithionol 5687:Agonists: 5664:T-0901317 5639:Meclizine 5569:Reserpine 5559:Phenytoin 5544:Octicizer 5504:Efavirenz 5431:Agonists: 5291:Yangambin 5029:Mianserin 4990:Histamine 4938:SCH-79687 4893:Enerisant 4888:Conessine 4789:Histamine 4742:Xaltidine 4727:Tiotidine 4687:Osutidine 4667:Metiamide 4652:Lamtidine 4563:Histamine 4548:Amthamine 4516:Trenizine 4411:iprindole 4365:mianserin 4353:amoxapine 4339:trazodone 4290:clozapine 4278:asenapine 4260:Zepastine 4240:Talastine 4230:Setastine 4220:Rocastine 4200:Perastine 4190:Octastine 4180:Moxastine 4135:Ketotifen 4100:Dorastine 4085:Clemizole 4060:Bilastine 3975:Talastine 3950:Piperoxan 3925:Perlapine 3915:Oxatomide 3905:Moxastine 3870:Meclozine 3810:Embramine 3750:Cyclizine 3685:Buclizine 3675:Bromazine 3655:Azatadine 3603:Histamine 3436:trazodone 3402:Perlapine 3296:Ketotifen 3276:Azatadine 3109:Oxatomide 3104:Meclizine 3089:Cyclizine 3062:Buclizine 3010:+naproxen 2965:Talastine 2950:Bilastine 2334:215408324 1694:30 August 1669:30 August 1359:Drugs.com 1337:billion. 1292:Tim Drake 1266:voiceover 1242:Marketing 1164:developed 1100:half life 1010:receptors 1003:histamine 944:effects ( 915:pregnancy 843:(hives), 841:urticaria 837:allergies 829:indicated 794:pregnancy 755:allergies 545:ChEMBL998 334:Excretion 319:half-life 220: OTC 151:Routes of 125:Pregnancy 73:Monograph 67:Drugs.com 8041:Medicine 7934:Tibolone 7813:Losartan 7766:Products 7585:Pirolate 7378:Zotepine 7263:Perazine 7178:Loxapine 6757:Mezepine 6742:Mazindol 6727:Loxapine 6712:Litracen 6450:Acridine 6380:See also 6268:SR-12813 6158:Piperine 6138:Orlistat 6108:Nicotine 5980:Fentanyl 5965:Febantel 5940:Ecopipam 5905:Dinaline 5790:Cafestol 5780:Bosentan 5654:PK-11195 5359:See also 5286:WEB-2086 5271:SR-27417 5266:SM-12502 5256:PCA-4248 5221:Etizolam 5201:BN-52063 5196:BN-50739 5148:Agonists 5124:receptor 5065:See also 5049:VUF-6002 5008:VUF-8430 4973:Agonists 4948:VUF-5681 4863:Bavisant 4843:A-423579 4838:A-349821 4822:Proxyfan 4772:Agonists 4558:Dimaprit 4553:Betazole 4541:Agonists 4476:Azanator 4449:loxapine 4357:loxapine 4318:zotepine 4105:Ebastine 3660:Bamipine 3586:Agonists 3462:Bamipine 3164:Bamipine 3026:Ebastine 2820:MM&M 2752:Archived 2731:Archived 2714:15626806 2654:Archived 2553:Archived 2523:26012715 2515:10444229 2480:25555379 2472:12169042 2437:19702548 2377:39936983 2369:15245363 2326:32251678 2291:23268457 2242:46791611 2234:15631542 2199:23723474 2140:18336052 2102:11136297 2020:35396016 1924:Archived 1920:14655812 1889:11533352 1823:21914581 1786:10 April 1780:DailyMed 1724:17229605 1689:ClinCalc 1663:Archived 1659:ClinCalc 1599:(2019). 1548:Archived 1518:Archived 1485:Archived 1450:10 April 1365:10 April 1224:ambroxol 927:sedation 831:for the 786:seizures 751:Claritin 737:(verify) 436:DrugBank 328:27 hours 177:ATC code 158:By mouth 140: B1 127:category 109:DailyMed 7223:Naranol 6657:Doxepin 6442:Classes 6368:Sesamin 6353:Zeranol 6283:Suramin 6053:LOE-908 5745:AMI-193 5659:S-07662 5574:TCPOBOP 5469:Chrysin 5318:Choline 5216:CV-6209 5211:CV-3988 5191:Apafant 5186:ABT-491 5181:A-85783 4858:AZD5213 4853:ABT-652 4848:ABT-239 4799:Immepip 4586:UR-AK49 4435:(e.g., 4403:doxepin 4381:(e.g., 4351:(e.g., 4329:(e.g., 4272:(e.g., 4267:Others: 3621:UR-AK49 3492:Doxepin 3453:topical 3434:(e.g., 3368:doxepin 3366:(e.g., 3361:Others: 3268:(e.g., 3156:Others: 2660:26 June 2630:8614120 2559:28 June 2349:Allergy 2282:3500039 2190:3667286 2148:9189476 2093:2015013 1639:6 March 1325:US$ 1.3 1318:US$ 360 1311:US$ 322 1290:, sees 1132:History 1075:of the 612:Formula 445:DB00455 391:PubChem 256:WARNING 228:: 193:) 187: ( 185:R06AX13 111::  87:a697038 8027:Portal 7997:Manual 7473:Others 6528:(TCAs) 5875:DHEA-S 5715:AA-861 5304:Others 5003:OUP-16 4794:Imetit 3421:Others 2712:  2705:539854 2702:  2628:  2612:(17). 2521:  2513:  2478:  2470:  2435:  2398:  2375:  2367:  2332:  2324:  2289:  2279:  2240:  2232:  2197:  2187:  2146:  2138:  2100:  2090:  2049:  2018:  2008:  1975:  1918:  1887:  1844:  1821:  1758:  1722:  1579:  1420:7 June 1335:  1328:  1321:  1314:  1280:PRIEST 1234:, and 1202:Brands 1085:CYP2D6 1081:CYP3A4 972:, and 958:CYP3A4 817:  788:, and 686:SMILES 653:382.89 536:ChEMBL 505:D00364 307:- and 305:CYP2D6 290:97–99% 253: 240: 107:  7990:Index 5474:CITCO 5241:L-652 5155:C-PAF 2519:S2CID 2476:S2CID 2373:S2CID 2330:S2CID 2238:S2CID 2214:Drugs 2144:S2CID 1949:7 May 1633:(FDA) 1629:U.S. 1440:(emc) 1332:US$ 5 1255:Boots 1057:NF-κB 869:is a 763:hives 706:InChI 662:JSmol 516:ChEBI 301:Liver 7570:P7C3 6046:and 5865:DHEA 5629:AITC 5494:DHEA 5136:PAFR 4568:HTMT 3608:HTMT 3451:For 2871:2017 2851:2020 2828:2017 2797:2017 2789:STAT 2760:2017 2710:PMID 2662:2016 2626:PMID 2606:JAMA 2591:2010 2561:2010 2511:PMID 2468:PMID 2433:PMID 2396:ISBN 2365:PMID 2322:PMID 2287:PMID 2230:PMID 2195:PMID 2136:PMID 2098:PMID 2047:ISBN 2016:PMID 2006:ISBN 1973:ISBN 1951:2012 1916:PMID 1885:PMID 1842:ISBN 1819:PMID 1788:2020 1756:ISBN 1720:PMID 1696:2024 1671:2024 1641:2023 1577:ISBN 1556:2016 1526:2016 1493:2016 1452:2020 1422:2022 1396:2023 1367:2020 1143:: a 929:and 773:, a 496:KEGG 476:UNII 465:3820 425:7216 405:3957 270:data 63:AHFS 5675:PXR 5419:CAR 5343:AAG 5338:LPC 5323:ATP 5165:PAF 5122:PAF 3455:use 2916:R06 2700:PMC 2692:doi 2688:330 2684:BMJ 2618:doi 2610:275 2503:doi 2460:doi 2425:doi 2357:doi 2314:doi 2310:177 2277:PMC 2269:doi 2222:doi 2185:PMC 2175:doi 2128:doi 2088:PMC 2080:doi 2039:doi 1998:doi 1875:doi 1871:108 1811:doi 1605:hdl 1389:FDA 561:EPA 395:CID 309:3A4 230:OTC 190:WHO 8053:: 5333:PC 4463:, 4459:, 4455:, 4451:, 4447:, 4443:, 4439:, 4425:, 4421:, 4417:, 4413:, 4409:, 4405:, 4401:, 4397:, 4393:, 4389:, 4385:, 4371:, 4367:, 4363:, 4359:, 4355:, 4341:, 4337:, 4333:, 4316:, 4312:, 4308:, 4304:, 4300:, 4296:, 4292:, 4288:, 4284:, 4280:, 4276:, 3430:: 3374:, 3370:, 3317:: 3264:: 3060:: 3042:: 2818:. 2805:^ 2787:. 2768:^ 2708:. 2698:. 2686:. 2682:. 2670:^ 2646:. 2624:. 2608:. 2577:. 2551:. 2545:. 2531:^ 2517:. 2509:. 2499:29 2497:. 2474:. 2466:. 2456:41 2454:. 2431:. 2419:. 2371:. 2363:. 2353:59 2351:. 2328:. 2320:. 2308:. 2285:. 2275:. 2263:. 2259:. 2236:. 2228:. 2218:65 2216:. 2193:. 2183:. 2171:58 2169:. 2165:. 2142:. 2134:. 2124:47 2122:. 2110:^ 2096:. 2086:. 2076:50 2074:. 2070:. 2045:. 2014:. 2004:. 1959:^ 1922:. 1912:68 1910:. 1906:. 1883:. 1869:. 1865:. 1817:. 1807:21 1805:. 1778:. 1732:^ 1716:16 1714:. 1687:. 1661:. 1657:. 1627:. 1546:. 1542:. 1512:. 1501:^ 1460:^ 1438:. 1412:. 1387:. 1383:. 1357:. 1298:. 1238:. 1230:, 1226:, 1222:, 1218:, 1214:, 1128:. 1083:, 1043:(K 1035:(K 1027:(K 968:, 964:, 858:. 784:, 629:Cl 626:23 620:22 249:US 236:UK 225:CA 216:AU 136:AU 104:US 8029:: 7654:e 7647:t 7640:v 6530:) 6523:( 6426:e 6419:t 6412:v 5881:) 5877:( 5871:) 5867:( 5500:) 5496:( 5399:e 5392:t 5385:v 5113:e 5106:t 5099:v 4996:L 4964:4 4962:H 4810:L 4763:3 4761:H 4579:L 4532:2 4530:H 4467:) 4429:) 4375:) 4345:) 4320:) 3614:L 3577:1 3575:H 3556:e 3549:t 3542:v 3438:) 3378:) 3272:) 3145:) 3141:( 3135:) 3131:( 3012:) 3008:( 2932:) 2930:* 2928:( 2918:) 2914:( 2904:e 2897:t 2890:v 2873:. 2830:. 2799:. 2762:. 2716:. 2694:: 2664:. 2632:. 2620:: 2593:. 2563:. 2525:. 2505:: 2482:. 2462:: 2439:. 2427:: 2421:3 2404:. 2379:. 2359:: 2336:. 2316:: 2293:. 2271:: 2265:4 2244:. 2224:: 2201:. 2177:: 2150:. 2130:: 2104:. 2082:: 2055:. 2041:: 2022:. 2000:: 1981:. 1953:. 1891:. 1877:: 1850:. 1825:. 1813:: 1790:. 1764:. 1726:. 1698:. 1673:. 1643:. 1607:: 1585:. 1558:. 1528:. 1495:. 1454:. 1424:. 1398:. 1369:. 1053:1 1049:1 1045:i 1037:i 1029:i 1020:i 1018:K 1016:( 1008:1 1006:H 664:) 641:2 638:O 635:2 632:N 623:H 617:C 563:) 559:( 303:( 251:: 238:: 218:: 138:: 65:/

Index



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Monograph
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a697038
License data
DailyMed
Loratadine
Pregnancy
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By mouth
Drug class
Second-generation antihistamine
ATC code
R06AX13
WHO
Legal status
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General sales list
WARNING
Pharmacokinetic
Bioavailability
Protein binding
Metabolism
Liver
CYP2D6
3A4

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