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to check the unmethylated and the methylated phenazone for its pharmacological properties. Knorr patented the compound in 1883. Filehne later suggested the names Höchstin or
Knorrin for the substance but Knorr telegraphed from his honeymoon that his variant of the name, antipyrine, is not to be
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Knorr became full professor at the
University of Jena in 1889. In the following two years, he planned and built a new laboratory suitable for his research. His focus gradually shifted from the structure of
280:("On the formation of carbon-nitrogen rings through the action of amine and hydrazine bases on acetoacetate and its derivatives"). In that time, during his search for
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and Knorr followed him and was made associate professor. Knorr described the time in WĂĽrzburg as most untroubled and most productive period of his life. Reactions of
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397:, Knorr served in the medical corps and returned to the University of Jena after the war ended. Knorr died after a short illness on 4 June 1921.
214:. After the early death of his father, the education of him and his four brothers lay in the hands of their mother. In 1878 Knorr received his
278:Ăśber die Bildung von Kohlenstoff-Stickstoff-Ringen durch Ein-wirkung von Amin-und Hydrazinbasen auf Acetessigester und seine Derivate
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Ludwig Knorr was born to a wealthy merchant family in 1859. He grew up in the
Sabbadini-Knorr company headquarters, located in the
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378:. In collaboration with various other chemists, Knorr proved the concept that ethyl acetoacetate existed in a
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in Munich. When Emil
Fischer became professor at the University of Erlangen, he asked Knorr to follow him.
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309:: Antipyrin bleibt!). In 1885 Knorr married Elisabeth Piloty, the sister of his laboratory colleague
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178:(2 December 1859 – 4 June 1921) was a German chemist. Together with Carl Paal, he discovered the
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are also named after him. The synthesis in 1883 of the analgesic drug antipyrine, now called
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with numerous other compounds were the main focus of his work there. After the death of
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was sent to WĂĽrzburg to evaluate whether Knorr was qualified for the position.
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Brune, K (1997). "The early history of non-opioid analgesics".
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became his tutor. In the summer of 1880 Knorr worked with
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in the center of Munich, and in the family house near the
428:"Plant Product Analogues and Compounds derived from Them"
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followed three years later in 1885 with a thesis titled
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related compounds, Knorr discovered the unmethylated
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268:In 1882 Knorr received his PhD for a thesis titled
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Grave yard at "Alter SĂĽdfriedhof" in Munich/Germany
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466:Berichte der Deutschen Chemischen Gesellschaft
393:became his main point of interest. During the
605:Ludwig Maximilian University of Munich alumni
464:"Ludwig Knorr. zum Gedächtnis (1859-1921)".
337:was searching for a new full professor and
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615:Academic staff of the University of Jena
407:List of German inventors and discoverers
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321:In 1885 Fischer became professor at the
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434:. Chichester: Wiley. pp. 125–126.
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218:and started to study chemistry at the
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500:Zeitschrift fĂĽr Angewandte Chemie
374:to the more general concept of
572:New International Encyclopedia
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547:10.1016/S1366-0071(97)80033-2
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620:19th-century German chemists
610:Heidelberg University alumni
600:20th-century German chemists
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198:in the early 20th century.
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331:Johann Georg Anton Geuther
16:German chemist (1859–1921)
432:Drug discovery: a history
270:Ăśber das Piperyl-Hydrazin
184:Knorr quinoline synthesis
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121:Knorr quinoline synthesis
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520:10.1002/ange.19210344802
478:10.1002/cber.19270600155
426:Walter Sneader. (2005).
243:University of Heidelberg
261:Antipyrine, now called
188:Knorr pyrrole synthesis
125:Knorr pyrrole synthesis
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323:University of WĂĽrzburg
317:University of WĂĽrzburg
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253:University of Erlangen
245:, and later assisted
231:University of Erlangen
102:University of Erlangen
566:"Knorr, Ludwig"
353:Tautomeric forms for
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239:Robert Wilhelm Bunsen
235:Hermann Emil Fischer
220:University of Munich
180:Paal–Knorr synthesis
154:Hermann Emil Fischer
117:Paal-Knorr synthesis
512:1921AngCh..34..269D
472:(1): A1–A34. 1921.
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355:ethyl acetoacetate
345:University of Jena
335:University of Jena
327:ethyl acetoacetate
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142:University of Jena
59:Kingdom of Bavaria
441:978-0-471-89979-2
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160:Doctoral students
132:Scientific career
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558:External links
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496:"Ludwig Knorr"
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71:(1921-06-04)
23:Ludwig Knorr
595:1921 deaths
590:1859 births
506:(48): 269.
395:World War I
376:tautomerism
294:antipyretic
88:Nationality
69:4 June 1921
584:Categories
535:Acute Pain
413:References
305:changed. (
202:Early life
182:, and the
47:1859-12-02
541:: 33–40.
372:pyrazoles
290:analgesic
286:Phenazone
263:Phenazone
192:phenazone
113:Phenazone
401:See also
391:morphine
575:. 1905.
508:Bibcode
382:and an
361:, R' =
300:at the
282:quinine
241:at the
196:Aspirin
81:Germany
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359:methyl
307:German
272:. His
216:Abitur
92:German
55:Munich
387:forms
363:ethyl
357:(R =
436:ISBN
384:enol
380:keto
292:and
186:and
77:Jena
66:Died
41:Born
543:doi
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
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