324:
301:
223:
198:
3506:
3476:
3446:
575:
3521:
1339:
will bind with G, which is called a G/T mismatch. When a G/T mismatch is recognized, hMutS alpha complex binds and exchanges ADP for ATP. The ADP-->ATP exchange causes a conformational change to convert hMutS alpha into a sliding clamp that can diffuse along the DNA backbone. The ATP induces a release of the complex from the DNA and allows the hMutS alpha to dissociate along the DNA like a sliding clamp. This transformation helps trigger downstream events to repair the damaged DNA.
3491:
582:
3461:
330:
229:
31:
1315:
In the human genome, hMSH6 is located on chromosome 2. It contains the Walker-A/B adenine nucleotide binding motif, which is the most highly conserved sequence found in all MutS homologs. As with other MutS homologs, hMSH6 has an intrinsic ATPase activity. It functions exclusively when bound to hMSH2
1351:
Mutations in the hMSH6 gene cause the protein to be nonfunctional or only partially active, thus reducing its ability to repair mistakes in DNA. The loss of MSH6 function results in instability at mononucleotide repeats. HNPCC is most commonly caused by mutations in hMSH2 and hMLH1, but mutations in
1448:
acetylation of histones H2A and H3 at the miR-155 promoter (where acetylation increases transcription). Measured by two different methods, miR-155 was over-expressed in sporadic colorectal cancers by either 22% or 50%. When miR-155 was elevated, hMSH2 was under-expressed in 44% to 67% of the same
1338:
Mismatch recognition by this complex is regulated by the ADP to ATP transformation, which provides evidence that hMutS alpha complex functions as a molecular switch. In normal DNA, adenine (A) bonds with thymine (T) and cytosine (C) bonds with guanine (G). Sometimes there will be a mismatch where T
3106:
Wijnen J, de Leeuw W, Vasen H, van der Klift H, Møller P, Stormorken A, Meijers-Heijboer H, Lindhout D, Menko F, Vossen S, Möslein G, Tops C, Bröcker-Vriends A, Wu Y, Hofstra R, Sijmons R, Cornelisse C, Morreau H, Fodde R (Oct 1999). "Familial endometrial cancer in female carriers of MSH6 germline
1356:
of colorectal cancer seems to be lower in these mutations, meaning that a low proportion of hMSH6 mutation carriers present with the disease. Endometrial cancer, on the other hand, seems to be a more important clinical manifestation for female mutation carriers. The onset of endometrial cancer and
1306:
because of its homology to MSH2. The identification of the human GTBP gene and subsequent amino acid sequence availability showed that yeast MSH6 and human GTBP were more related to each other than any other MutS homolog, with a 26.6% amino acid identity. Thus, GTBP took on the name human MSH6, or
1329:
Mismatches commonly occur as a result of DNA replication errors, genetic recombination, or other chemical and physical factors. Recognizing those mismatches and repairing them is extremely important for cells, because failure to do so results in microsatellite instability, an elevated spontaneous
1347:
Although mutations in hMSH2 cause a strong general mutator phenotype, mutations in hMSH6 cause only a modest mutator phenotype. At the gene level, the mutations were found to cause primarily single-base substitution mutations, which suggests that the role of hMSH6 is primarily for correcting
3003:
Wei Q, Guan Y, Cheng L, Radinsky R, Bar-Eli M, Tsan R, Li L, Legerski RJ (1998). "Expression of five selected human mismatch repair genes simultaneously detected in normal and cancer cell lines by a nonradioactive multiplex reverse transcription-polymerase chain reaction".
57:
3076:
Wang Q, Lasset C, Desseigne F, Saurin JC, Maugard C, Navarro C, Ruano E, Descos L, Trillet-Lenoir V, Bosset JF, Puisieux A (1999). "Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, hPMS2, and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal cancer".
2349:
Bocker T, Barusevicius A, Snowden T, Rasio D, Guerrette S, Robbins D, Schmidt C, Burczak J, Croce CM, Copeland T, Kovatich AJ, Fishel R (Feb 1999). "hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis".
1951:
Valeri N, Gasparini P, Fabbri M, Braconi C, Veronese A, Lovat F, Adair B, Vannini I, Fanini F, Bottoni A, Costinean S, Sandhu SK, Nuovo GJ, Alder H, Gafa R, Calore F, Ferracin M, Lanza G, Volinia S, Negrini M, McIlhatton MA, Amadori D, Fishel R, Croce CM (2010).
2887:
Yin J, Kong D, Wang S, Zou TT, Souza RF, Smolinski KN, Lynch PM, Hamilton SR, Sugimura H, Powell SM, Young J, Abraham JM, Meltzer SJ (1998). "Mutation of hMSH3 and hMSH6 mismatch repair genes in genetically unstable human colorectal and gastric carcinomas".
2052:
Aure MR, Leivonen SK, Fleischer T, Zhu Q, Overgaard J, Alsner J, Tramm T, Louhimo R, Alnæs GI, Perälä M, Busato F, Touleimat N, Tost J, Børresen-Dale AL, Hautaniemi S, Troyanskaya OG, Lingjærde OC, Sahlberg KK, Kristensen VN (2013).
2104:
Krzeminski P, Sarasquete ME, Misiewicz-Krzeminska I, Corral R, Corchete LA, Martín AA, García-Sanz R, San Miguel JF, Gutiérrez NC (2015). "Insights into epigenetic regulation of microRNA-155 expression in multiple myeloma".
1279:. It is the homologue of the human "G/T binding protein," (GTBP) also called p160 or hMSH6 (human MSH6). The MSH6 protein is a member of the Mutator S (MutS) family of proteins that are involved in DNA damage repair.
3187:
Kolodner RD, Tytell JD, Schmeits JL, Kane MF, Gupta RD, Weger J, Wahlberg S, Fox EA, Peel D, Ziogas A, Garber JE, Syngal S, Anton-Culver H, Li FP (Oct 1999). "Germ-line msh6 mutations in colorectal cancer families".
337:
236:
2849:
Miyaki M, Konishi M, Tanaka K, Kikuchi-Yanoshita R, Muraoka M, Yasuno M, Igari T, Koike M, Chiba M, Mori T (Nov 1997). "Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer".
2649:
Palombo F, Gallinari P, Iaccarino I, Lettieri T, Hughes M, D'Arrigo A, Truong O, Hsuan JJ, Jiricny J (Jun 1995). "GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells".
2528:"A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein"
2687:
Papadopoulos N, Nicolaides NC, Liu B, Parsons R, Lengauer C, Palombo F, D'Arrigo A, Markowitz S, Willson JK, Kinzler KW (Jun 1995). "Mutations of GTBP in genetically unstable cells".
1388:, to cause reduced expression of their proteins. If one or the other of these two microRNAs is over-expressed, hMSH2 and hMSH6 proteins are under-expressed, resulting in reduced
2140:
Chang S, Wang RH, Akagi K, Kim KA, Martin BK, Cavallone L, Haines DC, Basik M, Mai P, Poggi E, Isaacs C, Looi LM, Mun KS, Greene MH, Byers SW, Teo SH, Deng CX, Sharan SK (2011).
2724:
Risinger JI, Umar A, Boyd J, Berchuck A, Kunkel TA, Barrett JC (Sep 1996). "Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair".
1418:. Hypomethylation of its promoter region is associated with increased expression of an miRNA. High expression of a microRNA causes repression of its target genes (see
1330:
mutation rate (mutator phenotype), and susceptibility to HNPCC. hMSH6 combines with hMSH2 to form the active protein complex, hMutS alpha, also called hMSH2-hMSH6.
1422:). In 66% to 90% of colon cancers, miR-21 was over-expressed, and generally the measured level of hMSH2 was decreased (and hMSH6 is unstable without hMSH2).
3505:
3475:
3445:
975:
3375:
956:
159:
3520:
2612:
Drummond JT, Li GM, Longley MJ, Modrich P (Jun 1995). "Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells".
3146:"Association of hereditary nonpolyposis colorectal cancer-related tumors displaying low microsatellite instability with MSH6 germline mutations"
1561:
1543:
1357:
also colon cancer in families with hMSH6 mutations is about 50 years. This is delayed compared to the age 44 onset of hMSH2-related tumors.
1885:
Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, Sumani KM, Alder H, Amadori D, Patel T, Nuovo GJ, Fishel R, Croce CM (2010).
3035:"Interactions of human hMSH2 with hMSH3 and hMSH2 with hMSH6: examination of mutations found in hereditary nonpolyposis colorectal cancer"
2302:"Interactions of human hMSH2 with hMSH3 and hMSH2 with hMSH6: examination of mutations found in hereditary nonpolyposis colorectal cancer"
3490:
3460:
1283:
1206:
1199:
2901:
3554:
3144:
Wu Y, Berends MJ, Mensink RG, Kempinga C, Sijmons RH, van Der Zee AG, Hollema H, Kleibeuker JH, Buys CH, Hofstra RM (Nov 1999).
3425:
1526:
3549:
54:
1505:
1723:
Friedberg EC, Walker GC, Siede W. (1995). DNA repair and mutagenesis. American
Society for Microbiology, Washington DC.
3211:"BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures"
2194:"BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures"
323:
2055:"Individual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors"
1630:
Fishel R, Kolodner RD (1995). "Identification of mismatch repair genes and their role in the development of cancer".
2567:
Wang Q, Zhang H, Guerrette S, Chen J, Mazurek A, Wilson T, Slupianek A, Skorski T, Fishel R, Greene MI (Aug 2001).
300:
1530:
1509:
3254:"Multiple mutations and frameshifts are the hallmark of defective hPMS2 in pZ189-transfected human tumor cells"
1020:
3297:"Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agents"
1001:
3383:
222:
197:
139:
3388:
3372:
2243:"MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation"
1419:
1458:
1393:
1316:
as a heterodimer, although hMSH2 itself can function as a homomultimer or as a heterodimer with hMSH3.
336:
235:
1887:"MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2)"
3418:
3332:"Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes"
2796:
Acharya S, Wilson T, Gradia S, Kane MF, Guerrette S, Marsischky GT, Kolodner R, Fishel R (Nov 1996).
2487:"Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes"
2377:
Acharya S, Wilson T, Gradia S, Kane MF, Guerrette S, Marsischky GT, Kolodner R, Fishel R (Nov 1996).
329:
228:
1348:
single-base substitution mutations and to a lesser extent single base insertion/deletion mutations.
126:
3397:
1275:
1161:
1157:
1153:
1102:
1098:
1094:
147:
1449:
tissues (and hMSH6 is likely under-expressed as well, and also unstable in the absence of hMSH2).
3393:
1182:
1149:
1123:
1090:
1482:
3411:
2809:
2696:
2659:
2621:
2390:
2254:
1965:
1898:
1678:
211:
2927:"The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch"
1783:"The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch"
167:
8:
1441:
1415:
1389:
1374:
1270:
2813:
2700:
2663:
2625:
2394:
2258:
1969:
1902:
1682:
1588:"Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair"
3170:
3145:
3132:
2956:
2913:
2875:
2749:
2166:
2141:
2081:
2054:
1988:
1953:
1921:
1886:
1859:
1834:
1812:
1445:
1430:
1404:
1291:
1287:
171:
3278:
3253:
3235:
3210:
3059:
3034:
2943:
2926:
2462:
2437:
2326:
2301:
2277:
2242:
2218:
2193:
1799:
1782:
1758:
1741:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
774:
769:
764:
759:
754:
749:
744:
739:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
663:
658:
653:
648:
643:
638:
633:
628:
623:
3353:
3318:
3283:
3240:
3197:
3175:
3124:
3094:
3064:
3021:
2991:
2948:
2905:
2867:
2837:
2832:
2797:
2784:
2741:
2712:
2675:
2637:
2590:
2549:
2508:
2467:
2418:
2413:
2378:
2359:
2331:
2282:
2223:
2171:
2122:
2086:
2034:
1993:
1926:
1864:
1835:"Atypical HNPCC owing to MSH6 germline mutations: analysis of a large Dutch pedigree"
1804:
1763:
1706:
1701:
1666:
1647:
1643:
1609:
119:
47:
3136:
2879:
2753:
151:
3343:
3308:
3273:
3265:
3230:
3222:
3165:
3157:
3116:
3086:
3054:
3046:
3013:
2981:
2960:
2938:
2917:
2897:
2859:
2827:
2817:
2774:
2733:
2704:
2667:
2629:
2580:
2539:
2498:
2457:
2449:
2408:
2398:
2321:
2313:
2272:
2262:
2213:
2205:
2161:
2153:
2114:
2076:
2066:
2024:
1983:
1973:
1916:
1906:
1854:
1846:
1816:
1794:
1753:
1696:
1686:
1639:
1599:
416:
347:
291:
246:
2029:
2012:
3514:: human MutSalpha (MSH2/MSH6) bound to a G T mispair, with ADP bound to MSH2 only
3379:
2569:"Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1"
2118:
1433:
1407:
391:
175:
1566:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1548:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2802:
Proceedings of the
National Academy of Sciences of the United States of America
2438:"hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci"
2383:
Proceedings of the
National Academy of Sciences of the United States of America
2247:
Proceedings of the
National Academy of Sciences of the United States of America
2071:
492:
2103:
3543:
3484:: human MutSalpha (MSH2/MSH6) bound to ADP and an O6-methyl-guanine T mispair
3269:
2986:
2969:
2822:
2403:
1691:
610:
574:
3454:: NMR solution structure of the PWWP domain of Mismatch repair protein hMSH6
2708:
2671:
2633:
2267:
1978:
1911:
1742:"hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA"
552:
430:
3357:
3348:
3331:
3322:
3313:
3296:
3287:
3244:
3201:
3179:
3128:
3098:
3050:
2779:
2762:
2594:
2585:
2568:
2553:
2544:
2527:
2512:
2503:
2486:
2471:
2363:
2317:
2286:
2227:
2175:
2126:
2090:
2038:
1997:
1930:
1868:
1767:
581:
409:
188:
3090:
3068:
3025:
2995:
2952:
2909:
2871:
2841:
2788:
2761:
Nicolaides NC, Palombo F, Kinzler KW, Vogelstein B, Jiricny J (Feb 1996).
2745:
2716:
2679:
2641:
2422:
2335:
1808:
1710:
1651:
1613:
1246:
1241:
3226:
2209:
1850:
1604:
1587:
1065:
1046:
30:
2902:
10.1002/(SICI)1098-1004(1997)10:6<474::AID-HUMU9>3.0.CO;2-D
2863:
2737:
2453:
2142:"Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155"
1353:
308:
205:
155:
3529:: human MutSalpha (MSH2/MSH6) bound to DNA with a single base T insert
3017:
96:
92:
88:
84:
80:
76:
2798:"hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6"
2379:"hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6"
1667:"hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6"
920:
375:
362:
274:
261:
163:
2848:
2157:
3252:
Ceccotti S, Ciotta C, Fronza G, Dogliotti E, Bignami M (Jul 2000).
3161:
1437:
1411:
1230:
3120:
2968:
Shiwaku HO, Wakatsuki S, Mori Y, Fukushige S, Horii A (Oct 1997).
2760:
3330:
Clark AB, Valle F, Drotschmann K, Gary RK, Kunkel TA (Nov 2000).
3209:
Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J (Apr 2000).
2648:
2485:
Clark AB, Valle F, Drotschmann K, Gary RK, Kunkel TA (Nov 2000).
2192:
Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J (Apr 2000).
1426:
1370:
1032:
987:
905:
901:
3105:
2686:
1954:"Modulation of mismatch repair and genomic stability by miR-155"
143:
130:, mutS homolog 6, GTBP, GTMBP, HNPCC5, HSAP, p160, MMRCS3, MSH-6
2526:
Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (Oct 2002).
2435:
1400:
1366:
1214:
942:
851:
intrinsic apoptotic signaling pathway in response to DNA damage
590:
3403:
2348:
3499:: human MutSalpha (MSH2/MSH6) bound to ADP and a G dU mispair
3251:
2967:
1470:
3469:: human MutSalpha (MSH2/MSH6) bound to ADP and a G T mispair
1950:
3032:
2436:
Kleczkowska HE, Marra G, Lettieri T, Jiricny J (Mar 2001).
2299:
1884:
1466:
1462:
1384:
1266:
3186:
3329:
3075:
2484:
3143:
2723:
2611:
2051:
399:
2795:
2525:
2376:
2013:"Genome-wide epigenetic regulation of miRNAs in cancer"
1360:
3033:
Guerrette S, Wilson T, Gradia S, Fishel R (Nov 1998).
2970:"Alternative splicing of GTBP in normal human tissues"
2566:
2300:
Guerrette S, Wilson T, Gradia S, Fishel R (Nov 1998).
821:
somatic recombination of immunoglobulin gene segments
564:
3002:
1290:
for HNPCC. hMSH6 mutations have also been linked to
3208:
2924:
2191:
1780:
1352:hMSH6 are linked to an atypical form of HNPCC. The
1522:
1520:
1518:
1501:
1499:
1497:
2139:
346:
245:
3541:
1324:
3389:GeneReviews/NCBI/NIH/UW entry on Lynch syndrome
3294:
2187:
2185:
1515:
1494:
1302:MSH6 was first identified in the budding yeast
1294:and the development of endometrial carcinomas.
16:Protein-coding gene in the species Homo sapiens
2886:
2010:
1629:
1527:GRCm38: Ensembl release 89: ENSMUSG00000005370
1282:Defects in hMSH6 are associated with atypical
3419:
2763:"Molecular cloning of the N-terminus of GTBP"
1632:Current Opinion in Genetics & Development
861:somatic hypermutation of immunoglobulin genes
2560:
2519:
2478:
2429:
2342:
2234:
2182:
2133:
1946:
1944:
1942:
1940:
881:negative regulation of DNA endoreduplication
2370:
2293:
1880:
1878:
1506:GRCh38: Ensembl release 89: ENSG00000116062
3426:
3412:
2925:Gradia S, Acharya S, Fishel R (Dec 1997).
2097:
1585:
876:mitotic G2 DNA damage checkpoint signaling
3396:at the U.S. National Library of Medicine
3347:
3312:
3277:
3234:
3169:
3058:
2985:
2942:
2831:
2821:
2778:
2584:
2543:
2502:
2461:
2412:
2402:
2325:
2276:
2266:
2217:
2165:
2080:
2070:
2028:
1987:
1977:
1937:
1920:
1910:
1858:
1798:
1757:
1700:
1690:
1603:
1284:hereditary nonpolyposis colorectal cancer
1875:
1828:
1826:
826:negative regulation of DNA recombination
816:positive regulation of helicase activity
801:positive regulation of isotype switching
796:cellular response to DNA damage stimulus
745:intracellular membrane-bounded organelle
2240:
1664:
1333:
3542:
1832:
1781:Gradia S, Acharya S, Fishel R (1997).
1739:
1735:
1733:
1731:
1729:
1625:
1623:
3407:
1823:
1581:
1579:
1577:
1575:
806:intrinsic apoptotic signaling pathway
719:ATP-dependent activity, acting on DNA
351:
312:
307:
250:
209:
204:
2045:
2004:
1717:
1483:Mismatch repair § MutS homologs
1361:Epigenetic control of MSH6 in cancer
3336:The Journal of Biological Chemistry
3301:The Journal of Biological Chemistry
2532:The Journal of Biological Chemistry
2491:The Journal of Biological Chemistry
1774:
1726:
1620:
1586:Marsischky GT, et al. (1996).
13:
3295:Christmann M, Kaina B (Nov 2000).
3150:American Journal of Human Genetics
2604:
1658:
1572:
1273:protein Msh6 in the budding yeast
811:maintenance of DNA repeat elements
14:
3566:
3366:
2011:Baer C, Claus R, Plass C (2013).
634:protein homodimerization activity
3519:
3504:
3489:
3474:
3459:
3444:
709:single guanine insertion binding
679:single thymine insertion binding
580:
573:
335:
328:
322:
299:
234:
227:
221:
196:
29:
3433:
1665:Acharya S, et al. (1996).
1452:
1414:in one or the other of its two
791:determination of adult lifespan
714:guanine/thymine mispair binding
3555:Saccharomyces cerevisiae genes
3039:Molecular and Cellular Biology
2306:Molecular and Cellular Biology
1833:Wagner A, et al. (2001).
1740:Gradia S, et al. (1999).
1554:
1536:
591:More reference expression data
553:More reference expression data
1:
2944:10.1016/S0092-8674(00)80490-0
2030:10.1158/0008-5472.CAN-12-3731
1800:10.1016/S0092-8674(00)80490-0
1759:10.1016/S1097-2765(00)80316-0
1488:
1325:Importance of mismatch repair
886:interstrand cross-link repair
684:four-way junction DNA binding
320:
219:
3384:National Institute of Health
2119:10.1016/j.bbagrm.2014.12.002
1958:Proc. Natl. Acad. Sci. U.S.A
1891:Proc. Natl. Acad. Sci. U.S.A
1644:10.1016/0959-437X(95)80055-7
1310:
1297:
7:
3550:Genes on human chromosome 2
1476:
1420:microRNA silencing of genes
1319:
694:double-stranded DNA binding
654:oxidized purine DNA binding
10:
3571:
2241:Wang Y, Qin J (Dec 2003).
2072:10.1186/gb-2013-14-11-r126
1394:microsatellite instability
659:methylated histone binding
3439:
1562:"Mouse PubMed Reference:"
1544:"Human PubMed Reference:"
1342:
1245:
1240:
1236:
1229:
1213:
1194:
1179:
1175:
1146:
1142:
1135:
1120:
1116:
1087:
1083:
1076:
1063:
1059:
1044:
1040:
1031:
1018:
1014:
999:
995:
986:
973:
969:
954:
950:
941:
926:
919:
915:
899:
689:MutLalpha complex binding
609:
605:
588:
572:
563:
550:
499:
490:
437:
428:
398:
390:
386:
369:
356:
319:
298:
289:
285:
268:
255:
218:
195:
186:
182:
137:
134:
124:
117:
112:
73:
68:
51:
46:
41:
37:
28:
23:
3398:Medical Subject Headings
2823:10.1073/pnas.93.24.13629
2404:10.1073/pnas.93.24.13629
1692:10.1073/pnas.93.24.13629
1399:One of these microRNAs,
1276:Saccharomyces cerevisiae
465:tendon of biceps brachii
3215:Genes & Development
2709:10.1126/science.7604266
2672:10.1126/science.7604265
2634:10.1126/science.7604264
2442:Genes & Development
2268:10.1073/pnas.2536810100
2198:Genes & Development
1979:10.1073/pnas.1002472107
1912:10.1073/pnas.1015541107
1457:MSH6 has been shown to
1429:, is regulated both by
1207:Chr 17: 88.28 – 88.3 Mb
891:replication fork arrest
871:pyrimidine dimer repair
846:meiotic mismatch repair
775:mismatch repair complex
3349:10.1074/jbc.C000513200
3314:10.1074/jbc.M005377200
3270:10.1093/nar/28.13.2577
3258:Nucleic Acids Research
3051:10.1128/mcb.18.11.6616
2987:10.1093/dnares/4.5.359
2780:10.1006/geno.1996.0067
2586:10.1038/sj.onc.1204625
2545:10.1074/jbc.M206194200
2504:10.1074/jbc.C000513200
2318:10.1128/mcb.18.11.6616
2107:Biochim. Biophys. Acta
1403:, is regulated by the
1200:Chr 2: 47.7 – 47.81 Mb
639:mismatched DNA binding
353:17 E4|17 57.87 cM
3091:10.1007/s004399900064
704:magnesium ion binding
314:Chromosome 17 (mouse)
3227:10.1101/gad.14.8.927
2210:10.1101/gad.14.8.927
1851:10.1136/jmg.38.5.318
1605:10.1101/gad.10.4.407
1425:The other microRNA,
1334:Mismatch recognition
212:Chromosome 2 (human)
69:List of PDB id codes
42:Available structures
3394:MSH6+protein,+human
2814:1996PNAS...9313629A
2701:1995Sci...268.1915P
2664:1995Sci...268.1912P
2626:1995Sci...268.1909D
2395:1996PNAS...9313629A
2259:2003PNAS..10015387W
1970:2010PNAS..107.6982V
1903:2010PNAS..10721098V
1683:1996PNAS...9313629A
1390:DNA mismatch repair
1375:DNA mismatch repair
1286:not fulfilling the
1271:DNA mismatch repair
831:DNA mismatch repair
664:damaged DNA binding
449:ganglionic eminence
3378:2007-08-15 at the
2864:10.1038/ng1197-271
2738:10.1038/ng0996-102
2454:10.1101/gad.191201
1292:endometrial cancer
1288:Amsterdam criteria
1021:ENSMUSG00000005370
784:Biological process
733:Cellular component
624:nucleotide binding
617:Molecular function
3537:
3536:
3342:(47): 36498–501.
3018:10.1159/000164141
2620:(5219): 1909–12.
2497:(47): 36498–501.
1897:(49): 21098–103.
1256:
1255:
1252:
1251:
1225:
1224:
1190:
1189:
1169:
1168:
1131:
1130:
1110:
1109:
1072:
1071:
1053:
1052:
1027:
1026:
1008:
1007:
982:
981:
963:
962:
911:
910:
866:isotype switching
750:MutSalpha complex
649:chromatin binding
601:
600:
597:
596:
559:
558:
546:
545:
484:
483:
382:
381:
281:
280:
108:
107:
104:
103:
52:Ortholog search:
3562:
3523:
3508:
3493:
3478:
3463:
3448:
3428:
3421:
3414:
3405:
3404:
3361:
3351:
3326:
3316:
3307:(46): 36256–62.
3291:
3281:
3248:
3238:
3205:
3183:
3173:
3140:
3102:
3072:
3062:
3029:
2999:
2989:
2964:
2946:
2921:
2883:
2845:
2835:
2825:
2808:(24): 13629–34.
2792:
2782:
2757:
2720:
2695:(5219): 1915–7.
2683:
2658:(5219): 1912–4.
2645:
2599:
2598:
2588:
2564:
2558:
2557:
2547:
2523:
2517:
2516:
2506:
2482:
2476:
2475:
2465:
2433:
2427:
2426:
2416:
2406:
2389:(24): 13629–34.
2374:
2368:
2367:
2346:
2340:
2339:
2329:
2297:
2291:
2290:
2280:
2270:
2253:(26): 15387–92.
2238:
2232:
2231:
2221:
2189:
2180:
2179:
2169:
2137:
2131:
2130:
2101:
2095:
2094:
2084:
2074:
2049:
2043:
2042:
2032:
2008:
2002:
2001:
1991:
1981:
1948:
1935:
1934:
1924:
1914:
1882:
1873:
1872:
1862:
1830:
1821:
1820:
1802:
1778:
1772:
1771:
1761:
1737:
1724:
1721:
1715:
1714:
1704:
1694:
1677:(24): 13629–34.
1662:
1656:
1655:
1627:
1618:
1617:
1607:
1583:
1570:
1569:
1558:
1552:
1551:
1540:
1534:
1524:
1513:
1503:
1416:promoter regions
1238:
1237:
1209:
1202:
1185:
1173:
1172:
1164:
1140:
1139:
1136:RefSeq (protein)
1126:
1114:
1113:
1105:
1081:
1080:
1057:
1056:
1038:
1037:
1012:
1011:
993:
992:
967:
966:
948:
947:
917:
916:
607:
606:
593:
584:
577:
570:
569:
555:
527:genital tubercle
515:primitive streak
511:secondary oocyte
495:
493:Top expressed in
488:
487:
473:cartilage tissue
453:secondary oocyte
441:ventricular zone
433:
431:Top expressed in
426:
425:
405:
404:
388:
387:
378:
365:
354:
339:
332:
326:
315:
303:
287:
286:
277:
264:
253:
238:
231:
225:
214:
200:
184:
183:
178:
176:MSH6 - orthologs
129:
122:
99:
66:
65:
60:
39:
38:
33:
21:
20:
3570:
3569:
3565:
3564:
3563:
3561:
3560:
3559:
3540:
3539:
3538:
3533:
3530:
3524:
3515:
3509:
3500:
3494:
3485:
3479:
3470:
3464:
3455:
3449:
3435:
3432:
3380:Wayback Machine
3369:
3364:
3264:(13): 2577–84.
3196:(20): 5068–74.
3190:Cancer Research
3109:Nature Genetics
3045:(11): 6616–23.
2937:(7): 995–1005.
2852:Nature Genetics
2726:Nature Genetics
2607:
2605:Further reading
2602:
2565:
2561:
2538:(43): 40362–7.
2524:
2520:
2483:
2479:
2434:
2430:
2375:
2371:
2352:Cancer Research
2347:
2343:
2312:(11): 6616–23.
2298:
2294:
2239:
2235:
2190:
2183:
2158:10.1038/nm.2459
2152:(10): 1275–82.
2138:
2134:
2102:
2098:
2050:
2046:
2009:
2005:
1949:
1938:
1883:
1876:
1831:
1824:
1793:(7): 995–1005.
1779:
1775:
1738:
1727:
1722:
1718:
1663:
1659:
1628:
1621:
1584:
1573:
1560:
1559:
1555:
1542:
1541:
1537:
1525:
1516:
1504:
1495:
1491:
1479:
1455:
1442:promoter region
1365:Two microRNAs,
1363:
1345:
1336:
1327:
1322:
1313:
1300:
1269:that codes for
1247:View/Edit Mouse
1242:View/Edit Human
1205:
1198:
1195:Location (UCSC)
1181:
1160:
1156:
1152:
1148:
1122:
1101:
1097:
1093:
1089:
1002:ENSG00000116062
895:
779:
740:Golgi apparatus
728:
674:protein binding
669:ATPase activity
589:
579:
578:
551:
542:
537:
533:
529:
525:
521:
517:
513:
509:
505:
491:
480:
477:Achilles tendon
475:
471:
467:
463:
459:
455:
451:
447:
443:
429:
373:
360:
352:
342:
341:
340:
333:
313:
290:Gene location (
272:
259:
251:
241:
240:
239:
232:
210:
187:Gene location (
138:
125:
118:
75:
53:
17:
12:
11:
5:
3568:
3558:
3557:
3552:
3535:
3534:
3532:
3531:
3525:
3518:
3516:
3510:
3503:
3501:
3495:
3488:
3486:
3480:
3473:
3471:
3465:
3458:
3456:
3450:
3443:
3440:
3437:
3436:
3431:
3430:
3423:
3416:
3408:
3402:
3401:
3391:
3386:
3368:
3367:External links
3365:
3363:
3362:
3327:
3292:
3249:
3206:
3184:
3162:10.1086/302612
3141:
3103:
3085:(1–2): 79–85.
3079:Human Genetics
3073:
3030:
3012:(6): 293–300.
3000:
2965:
2922:
2890:Human Mutation
2884:
2846:
2793:
2758:
2721:
2684:
2646:
2608:
2606:
2603:
2601:
2600:
2579:(34): 4640–9.
2559:
2518:
2477:
2428:
2369:
2341:
2292:
2233:
2181:
2132:
2096:
2044:
2003:
1964:(15): 6982–7.
1936:
1874:
1822:
1773:
1746:Molecular Cell
1725:
1716:
1657:
1619:
1571:
1553:
1535:
1514:
1492:
1490:
1487:
1486:
1485:
1478:
1475:
1454:
1451:
1392:and increased
1362:
1359:
1344:
1341:
1335:
1332:
1326:
1323:
1321:
1318:
1312:
1309:
1299:
1296:
1263:mutS homolog 6
1254:
1253:
1250:
1249:
1244:
1234:
1233:
1227:
1226:
1223:
1222:
1220:
1218:
1211:
1210:
1203:
1196:
1192:
1191:
1188:
1187:
1177:
1176:
1170:
1167:
1166:
1144:
1143:
1137:
1133:
1132:
1129:
1128:
1118:
1117:
1111:
1108:
1107:
1085:
1084:
1078:
1074:
1073:
1070:
1069:
1061:
1060:
1054:
1051:
1050:
1042:
1041:
1035:
1029:
1028:
1025:
1024:
1016:
1015:
1009:
1006:
1005:
997:
996:
990:
984:
983:
980:
979:
971:
970:
964:
961:
960:
952:
951:
945:
939:
938:
933:
928:
924:
923:
913:
912:
909:
908:
897:
896:
894:
893:
888:
883:
878:
873:
868:
863:
858:
856:response to UV
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
787:
785:
781:
780:
778:
777:
772:
767:
762:
757:
752:
747:
742:
736:
734:
730:
729:
727:
726:
724:enzyme binding
721:
716:
711:
706:
701:
696:
691:
686:
681:
676:
671:
666:
661:
656:
651:
646:
641:
636:
631:
626:
620:
618:
614:
613:
603:
602:
599:
598:
595:
594:
586:
585:
567:
561:
560:
557:
556:
548:
547:
544:
543:
541:
540:
536:
532:
531:abdominal wall
528:
524:
523:tail of embryo
520:
519:primary oocyte
516:
512:
508:
504:
500:
497:
496:
485:
482:
481:
479:
478:
474:
470:
466:
462:
458:
454:
450:
446:
442:
438:
435:
434:
422:
421:
413:
402:
396:
395:
392:RNA expression
384:
383:
380:
379:
371:
367:
366:
358:
355:
350:
344:
343:
334:
327:
321:
317:
316:
311:
305:
304:
296:
295:
283:
282:
279:
278:
270:
266:
265:
257:
254:
249:
243:
242:
233:
226:
220:
216:
215:
208:
202:
201:
193:
192:
180:
179:
136:
132:
131:
123:
115:
114:
110:
109:
106:
105:
102:
101:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
9:
6:
4:
3:
2:
3567:
3556:
3553:
3551:
3548:
3547:
3545:
3528:
3522:
3517:
3513:
3507:
3502:
3498:
3492:
3487:
3483:
3477:
3472:
3468:
3462:
3457:
3453:
3447:
3442:
3441:
3438:
3429:
3424:
3422:
3417:
3415:
3410:
3409:
3406:
3399:
3395:
3392:
3390:
3387:
3385:
3381:
3377:
3374:
3373:FAQs on HNPCC
3371:
3370:
3359:
3355:
3350:
3345:
3341:
3337:
3333:
3328:
3324:
3320:
3315:
3310:
3306:
3302:
3298:
3293:
3289:
3285:
3280:
3275:
3271:
3267:
3263:
3259:
3255:
3250:
3246:
3242:
3237:
3232:
3228:
3224:
3221:(8): 927–39.
3220:
3216:
3212:
3207:
3203:
3199:
3195:
3191:
3185:
3181:
3177:
3172:
3167:
3163:
3159:
3156:(5): 1291–8.
3155:
3151:
3147:
3142:
3138:
3134:
3130:
3126:
3122:
3121:10.1038/13773
3118:
3114:
3110:
3104:
3100:
3096:
3092:
3088:
3084:
3080:
3074:
3070:
3066:
3061:
3056:
3052:
3048:
3044:
3040:
3036:
3031:
3027:
3023:
3019:
3015:
3011:
3007:
3001:
2997:
2993:
2988:
2983:
2980:(5): 359–62.
2979:
2975:
2971:
2966:
2962:
2958:
2954:
2950:
2945:
2940:
2936:
2932:
2928:
2923:
2919:
2915:
2911:
2907:
2903:
2899:
2895:
2891:
2885:
2881:
2877:
2873:
2869:
2865:
2861:
2857:
2853:
2847:
2843:
2839:
2834:
2829:
2824:
2819:
2815:
2811:
2807:
2803:
2799:
2794:
2790:
2786:
2781:
2776:
2772:
2768:
2764:
2759:
2755:
2751:
2747:
2743:
2739:
2735:
2731:
2727:
2722:
2718:
2714:
2710:
2706:
2702:
2698:
2694:
2690:
2685:
2681:
2677:
2673:
2669:
2665:
2661:
2657:
2653:
2647:
2643:
2639:
2635:
2631:
2627:
2623:
2619:
2615:
2610:
2609:
2596:
2592:
2587:
2582:
2578:
2574:
2570:
2563:
2555:
2551:
2546:
2541:
2537:
2533:
2529:
2522:
2514:
2510:
2505:
2500:
2496:
2492:
2488:
2481:
2473:
2469:
2464:
2459:
2455:
2451:
2448:(6): 724–36.
2447:
2443:
2439:
2432:
2424:
2420:
2415:
2410:
2405:
2400:
2396:
2392:
2388:
2384:
2380:
2373:
2365:
2361:
2358:(4): 816–22.
2357:
2353:
2345:
2337:
2333:
2328:
2323:
2319:
2315:
2311:
2307:
2303:
2296:
2288:
2284:
2279:
2274:
2269:
2264:
2260:
2256:
2252:
2248:
2244:
2237:
2229:
2225:
2220:
2215:
2211:
2207:
2204:(8): 927–39.
2203:
2199:
2195:
2188:
2186:
2177:
2173:
2168:
2163:
2159:
2155:
2151:
2147:
2143:
2136:
2128:
2124:
2120:
2116:
2113:(3): 353–66.
2112:
2108:
2100:
2092:
2088:
2083:
2078:
2073:
2068:
2064:
2060:
2056:
2048:
2040:
2036:
2031:
2026:
2022:
2018:
2014:
2007:
1999:
1995:
1990:
1985:
1980:
1975:
1971:
1967:
1963:
1959:
1955:
1947:
1945:
1943:
1941:
1932:
1928:
1923:
1918:
1913:
1908:
1904:
1900:
1896:
1892:
1888:
1881:
1879:
1870:
1866:
1861:
1856:
1852:
1848:
1845:(5): 318–22.
1844:
1840:
1839:J. Med. Genet
1836:
1829:
1827:
1818:
1814:
1810:
1806:
1801:
1796:
1792:
1788:
1784:
1777:
1769:
1765:
1760:
1755:
1752:(2): 255–61.
1751:
1747:
1743:
1736:
1734:
1732:
1730:
1720:
1712:
1708:
1703:
1698:
1693:
1688:
1684:
1680:
1676:
1672:
1668:
1661:
1653:
1649:
1645:
1641:
1638:(3): 382–95.
1637:
1633:
1626:
1624:
1615:
1611:
1606:
1601:
1598:(4): 407–20.
1597:
1593:
1589:
1582:
1580:
1578:
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1413:
1410:state of the
1409:
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1402:
1397:
1395:
1391:
1387:
1386:
1380:
1376:
1373:, target the
1372:
1368:
1358:
1355:
1349:
1340:
1331:
1317:
1308:
1305:
1304:S. cerevisiae
1295:
1293:
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1280:
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1277:
1272:
1268:
1264:
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1127:
1125:
1119:
1115:
1112:
1106:
1104:
1100:
1096:
1092:
1086:
1082:
1079:
1077:RefSeq (mRNA)
1075:
1068:
1067:
1062:
1058:
1055:
1049:
1048:
1043:
1039:
1036:
1034:
1030:
1023:
1022:
1017:
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1003:
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985:
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972:
968:
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953:
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934:
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869:
867:
864:
862:
859:
857:
854:
852:
849:
847:
844:
842:
839:
837:
836:viral process
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
788:
786:
783:
782:
776:
773:
771:
768:
766:
763:
761:
758:
756:
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751:
748:
746:
743:
741:
738:
737:
735:
732:
731:
725:
722:
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715:
712:
710:
707:
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677:
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645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
621:
619:
616:
615:
612:
611:Gene ontology
608:
604:
592:
587:
583:
576:
571:
568:
566:
562:
554:
549:
538:
535:Gonadal ridge
534:
530:
526:
522:
518:
514:
510:
506:
502:
501:
498:
494:
489:
486:
476:
472:
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397:
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177:
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149:
145:
141:
133:
128:
121:
116:
111:
100:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
3526:
3511:
3496:
3481:
3466:
3451:
3339:
3335:
3304:
3300:
3261:
3257:
3218:
3214:
3193:
3189:
3153:
3149:
3115:(2): 142–4.
3112:
3108:
3107:mutations".
3082:
3078:
3042:
3038:
3009:
3006:Pathobiology
3005:
2977:
2974:DNA Research
2973:
2934:
2930:
2896:(6): 474–8.
2893:
2889:
2858:(3): 271–2.
2855:
2851:
2805:
2801:
2773:(3): 395–7.
2770:
2766:
2732:(1): 102–5.
2729:
2725:
2692:
2688:
2655:
2651:
2617:
2613:
2576:
2572:
2562:
2535:
2531:
2521:
2494:
2490:
2480:
2445:
2441:
2431:
2386:
2382:
2372:
2355:
2351:
2344:
2309:
2305:
2295:
2250:
2246:
2236:
2201:
2197:
2149:
2145:
2135:
2110:
2106:
2099:
2065:(11): R126.
2062:
2058:
2047:
2023:(2): 473–7.
2020:
2016:
2006:
1961:
1957:
1894:
1890:
1842:
1838:
1790:
1786:
1776:
1749:
1745:
1719:
1674:
1670:
1660:
1635:
1631:
1595:
1591:
1565:
1556:
1547:
1538:
1456:
1453:Interactions
1424:
1398:
1382:
1378:
1377:(MMR) genes
1364:
1350:
1346:
1337:
1328:
1314:
1303:
1301:
1281:
1274:
1262:
1258:
1257:
1180:
1162:NP_001268423
1158:NP_001268422
1154:NP_001268421
1147:
1121:
1103:NM_001281494
1099:NM_001281493
1095:NM_001281492
1088:
1064:
1045:
1019:
1000:
974:
955:
935:
930:
415:
408:
135:External IDs
74:
18:
3434:PDB gallery
2059:Genome Biol
1438:CpG islands
1434:methylation
1412:CpG islands
1408:methylation
755:nucleoplasm
699:ATP binding
644:ADP binding
629:DNA binding
374:88,298,320
361:88,282,490
273:47,810,063
260:47,695,530
113:Identifiers
3544:Categories
2017:Cancer Res
1533:, May 2017
1512:, May 2017
1489:References
1446:epigenetic
1431:epigenetic
1405:epigenetic
1354:penetrance
841:DNA repair
760:chromosome
469:left ovary
419:(ortholog)
156:HomoloGene
3382:from the
1592:Genes Dev
1311:Structure
1298:Discovery
1183:NP_034960
1150:NP_000170
1124:NM_010830
1091:NM_000179
921:Orthologs
164:GeneCards
3376:Archived
3358:11005803
3323:10954713
3288:10871409
3245:10783165
3202:10537275
3180:10521294
3137:30251596
3129:10508506
3099:10480359
2880:22473295
2767:Genomics
2754:25456490
2595:11498787
2573:Oncogene
2554:12171929
2513:11005803
2472:11274057
2364:10029069
2287:14657349
2228:10783165
2176:21946536
2146:Nat. Med
2127:25497370
2091:24257477
2039:23316035
1998:20351277
1931:21078976
1869:11333868
1768:10078208
1529:–
1508:–
1477:See also
1459:interact
1320:Function
1231:Wikidata
900:Sources:
507:epiblast
3171:1288281
3069:9774676
3026:9491849
2996:9455487
2961:3551402
2953:9428522
2918:2564806
2910:9401011
2872:9354786
2842:8942985
2810:Bibcode
2789:8838326
2746:8782829
2717:7604266
2697:Bibcode
2689:Science
2680:7604265
2660:Bibcode
2652:Science
2642:7604264
2622:Bibcode
2614:Science
2423:8942985
2391:Bibcode
2336:9774676
2255:Bibcode
2167:3501198
2082:4053776
1989:2872463
1966:Bibcode
1922:3000294
1899:Bibcode
1860:1734864
1817:3551402
1809:9428522
1711:8942985
1679:Bibcode
1652:7549435
1614:8600025
1531:Ensembl
1510:Ensembl
1444:and by
1440:in its
1436:of the
1427:miR-155
1371:miR-155
1307:hMSH6.
1033:UniProt
988:Ensembl
927:Species
906:QuickGO
770:cytosol
765:nucleus
394:pattern
152:1343961
120:Aliases
3400:(MeSH)
3356:
3321:
3286:
3279:102707
3276:
3243:
3236:316544
3233:
3200:
3178:
3168:
3135:
3127:
3097:
3067:
3060:109246
3057:
3024:
2994:
2959:
2951:
2916:
2908:
2878:
2870:
2840:
2830:
2787:
2752:
2744:
2715:
2678:
2640:
2593:
2552:
2511:
2470:
2463:312660
2460:
2421:
2411:
2362:
2334:
2327:109246
2324:
2285:
2278:307577
2275:
2226:
2219:316544
2216:
2174:
2164:
2125:
2089:
2079:
2037:
1996:
1986:
1929:
1919:
1867:
1857:
1815:
1807:
1766:
1709:
1699:
1650:
1612:
1343:Cancer
1217:search
1215:PubMed
1066:P54276
1047:P52701
943:Entrez
565:BioGPS
539:thymus
503:zygote
445:embryo
252:2p16.3
144:600678
3133:S2CID
2957:S2CID
2914:S2CID
2876:S2CID
2833:19374
2750:S2CID
2414:19374
1813:S2CID
1702:19374
1471:BRCA1
1461:with
1401:miR21
1379:hMSH6
1367:miR21
1265:is a
976:17688
936:Mouse
931:Human
902:Amigo
461:ovary
457:gonad
417:Mouse
410:Human
357:Start
292:Mouse
256:Start
189:Human
3527:2o8f
3512:2o8e
3497:2o8d
3482:2o8c
3467:2o8b
3452:2gfu
3354:PMID
3319:PMID
3284:PMID
3241:PMID
3198:PMID
3176:PMID
3125:PMID
3095:PMID
3065:PMID
3022:PMID
2992:PMID
2949:PMID
2931:Cell
2906:PMID
2868:PMID
2838:PMID
2785:PMID
2742:PMID
2713:PMID
2676:PMID
2638:PMID
2591:PMID
2550:PMID
2509:PMID
2468:PMID
2419:PMID
2360:PMID
2332:PMID
2283:PMID
2224:PMID
2172:PMID
2123:PMID
2111:1849
2087:PMID
2035:PMID
1994:PMID
1927:PMID
1865:PMID
1805:PMID
1787:Cell
1764:PMID
1707:PMID
1671:PNAS
1648:PMID
1610:PMID
1469:and
1467:PCNA
1463:MSH2
1385:MSH2
1381:and
1369:and
1267:gene
1259:MSH6
957:2956
400:Bgee
348:Band
309:Chr.
247:Band
206:Chr.
168:MSH6
140:OMIM
127:MSH6
97:2O8E
93:2O8D
89:2O8C
85:2O8B
81:2GFU
77:2O8F
58:RCSB
55:PDBe
24:MSH6
3344:doi
3340:275
3309:doi
3305:275
3274:PMC
3266:doi
3231:PMC
3223:doi
3166:PMC
3158:doi
3117:doi
3087:doi
3083:105
3055:PMC
3047:doi
3014:doi
2982:doi
2939:doi
2898:doi
2860:doi
2828:PMC
2818:doi
2775:doi
2734:doi
2705:doi
2693:268
2668:doi
2656:268
2630:doi
2618:268
2581:doi
2540:doi
2536:277
2499:doi
2495:275
2458:PMC
2450:doi
2409:PMC
2399:doi
2322:PMC
2314:doi
2273:PMC
2263:doi
2251:100
2214:PMC
2206:doi
2162:PMC
2154:doi
2115:doi
2077:PMC
2067:doi
2025:doi
1984:PMC
1974:doi
1962:107
1917:PMC
1907:doi
1895:107
1855:PMC
1847:doi
1795:doi
1754:doi
1697:PMC
1687:doi
1640:doi
1600:doi
1261:or
370:End
269:End
172:OMA
160:149
148:MGI
48:PDB
3546::
3352:.
3338:.
3334:.
3317:.
3303:.
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