763:. Originally, mTORC2 was identified as a rapamycin-insensitive entity, as acute exposure to rapamycin did not affect mTORC2 activity or Akt phosphorylation. However, subsequent studies have shown that, at least in some cell lines, chronic exposure to rapamycin, while not affecting pre-existing mTORC2s, promotes rapamycin inhibition of free mTOR molecules, thus inhibiting the formation of new mTORC2. mTORC2 can be inhibited by chronic treatment with rapamycin
6086:
822:/PKC) protein kinase family. mTORC2 regulates actin cytoskeleton through PKCα but is able to phosphorylate other members of the PKC family that have various regulatory functions in cell migration and cytoskeletal remodeling. mTORC2 plays a pivotal role in phosphorylation and thus in activation of Akt, which is a vital signaling component downstream from PI3K once active, and also in phosphorylation of
843:. In many types of human cancer, hyperactivation of mTORC2 caused by mutations and aberrant amplifications of mTORC2 core components is frequently observed. On metabolic level, activation of mTORC2 stimulates processes related to alteration of glucose metabolism in cancer cells, altogether known as
838:
Since mTORC2 plays a crucial role in metabolic regulation, it can be linked to many human pathologies. Deregulation of mTOR signaling, including mTORC2, affects transduction of insulin signal and therefore can disrupt its biological functions and lead to metabolic disorders, such as
927:
in skeletal muscle results in decreased insulin-stimulated glucose uptake, and resistance to the effects of an mTOR kinase inhibitor on insulin resistance, highlighting a critical role for mTOR in the regulation of glucose homeostasis in this tissue. Loss of
790:
at the plasma membrane. mSin1 subunit can also be phosphorylated by Akt. This indicates the existence of a positive feedback loop in which partial activation of Akt stimulates the activation of mTORC2. The complex then phosphorylates and fully activates Akt.
2208:"Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer"
1371:
Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB, et al. (January 1998). "Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B".
783:. This domain is vital for the insulin-dependent regulation of mTORC2 activity and inhibits the catalytic activity of mTORC2 in the absence of insulin. This autoinhibition is relieved upon binding to PI3K-generated
737:; however, this may be due to its association with Akt. It is not clear if these membranes display mTORC2 activity in the cellular context, or if these pools contribute to phosphorylation of mTORC2 substrates.
2721:
Jhanwar-Uniyal M, Amin AG, Cooper JB, Das K, Schmidt MH, Murali R (May 2017). "Discrete signaling mechanisms of mTORC1 and mTORC2: Connected yet apart in cellular and molecular aspects".
620:
Though less understood than mTORC1, mTORC2 has been shown to respond to growth factors and to modulate cell metabolism and cell survival, thanks to its activation of the survival kinase
3949:
4234:
936:
results in reduced beta cell mass and insulin secretion, and hyperglycemia and glucose intolerance. mTORC2 activity in the hypothalamus of mice increases with age, and deletion of
915:
leads to glucose intolerance, hepatic insulin resistance, decreased hepatic lipogenesis, and decreased male lifespan. Adipose-specific disruption of mTORC2 through deletion of
802:, a negative regulator of insulin/IGF-1 receptor signaling upstream of Akt and mTORC2, is phosphorylated and therefore activated by mTORC1. Additionally, some components of
1914:
Lin, Yiyan; Pal, Dhiman Sankar; Banerjee, Parijat; Banerjee, Tatsat; Qin, Guanghui; Deng, Yu; Borleis, Jane; Iglesias, Pablo A.; Devreotes, Peter N. (2024-07-01).
759:
mTORC2 appears to be regulated by insulin, growth factors, and serum. In contrast to TORC1, which is mainly stimulated by nutrients, TORC2 is mainly stimulated by
580:
remodeling. The complex itself is rather large, consisting of seven protein subunits. The catalytic mTOR subunit, DEP domain containing mTOR-interacting protein (
3942:
3935:
4142:
1415:
Beevers CS, Li F, Liu L, Huang S (August 2006). "Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells".
1211:"Feature Article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology"
430:
289:
205:
52:
5487:
5529:
4690:
3993:
5638:
1857:
Pal, Dhiman Sankar; Banerjee, Tatsat; Lin, Yiyan; de
Trogoff, Félix; Borleis, Jane; Iglesias, Pablo A.; Devreotes, Peter N. (July 2023).
1660:"mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR"
1262:"Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton"
3095:"Lifespan extension without fertility reduction following dietary addition of the autophagy activator Torin1 in Drosophila melanogaster"
4376:
4263:
1320:
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (February 2005). "Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex".
4651:
605:
5624:
5443:
5089:
4685:
4675:
4670:
3980:
3962:
562:
1566:"mTOR/p70S6K signaling distinguishes routine, maintenance-level autophagy from autophagic cell death during influenza A infection"
923:
and insulin resistance in older mice. The role of mTORC2 in skeletal muscle has taken time to uncover, but genetic loss of mTORC2/
5726:
5607:
210:
5313:
4182:
3672:"Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity"
435:
294:
702:
inhibits both by preventing phosphorylation of the serine. Moreover, mTORC2 activity has been implicated in the regulation of
57:
6116:
5377:
4352:
3623:"Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism"
2631:
6121:
6111:
6106:
5633:
3272:"mTORC2 Activity Disrupts Lysosome Acidification in Systemic Lupus Erythematosus by Impairing Caspase-1 Cleavage of Rab39a"
3513:"Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging"
4167:
454:
313:
76:
725:
The precise localization of mTORC2 inside cells is still unclear. Some findings based on its activity point to cellular
5365:
3362:"Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2"
5690:
806:
signalling has been revealed as important regulators of mTORC2 activity as Ric-8B protein and some lipid metabolites.
5805:
4622:
4612:
4297:
794:
What might come as a surprise is that mTORC2 signaling is also regulated by mTORC1. This is due to the presence of a
3927:
882:
with no reduction in fertility and Akt haploinsufficiency, an mTORC2 downstream target, extended lifespan in mice.
5304:
442:
301:
217:
64:
3152:
Nojima A, Yamashita M, Yoshida Y, Shimizu I, Ichimiya H, Kamimura N, et al. (2013-07-30). Sadoshima J (ed.).
2807:"mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc"
5573:
5245:
4607:
4598:
2357:"The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling"
612:) can only be found in mTORC2. Rictor has been shown to be the scaffold protein for substrate binding to mTORC2.
779:
Similar to other PI3K regulated proteins, mTORC2 has a mSin1 subunit, which contains a phosphoinositide-binding
6136:
2907:"A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity"
690:
residue S473 as well as serine residue S450. Phosphorylation of the serine stimulates Akt phosphorylation at a
874:. By contrast, dietary administration of Torin1, a dual mTORC1/2 inhibitor, resulted in prolonged lifespan in
814:
mTORC2 controls cell survival and proliferation mainly through phosphorylation of several members of the AGC (
5961:
4988:
4485:
4476:
4133:
4079:
733:, as a possible site of mTORC2, whereas other suggest that the complex could be additionally located at the
37:
22:
2465:"Catecholamine-induced lipolysis causes mTOR complex dissociation and inhibits glucose uptake in adipocytes"
628:-dependent manner. The complex also plays a role as an important regulator in the organization of the actin
4176:
897:
711:
447:
306:
222:
3866:
Chellappa K, Brinkman JA, Mukherjee S, Morrison M, Alotaibi MI, Carbajal KA, et al. (October 2019).
69:
2674:"PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12"
6126:
6076:
5200:
5018:
4514:
6062:
6049:
6036:
6023:
6010:
5997:
5984:
5946:
5190:
5185:
5180:
5170:
5165:
5160:
5150:
4945:
4720:
4316:
3511:
Arriola Apelo SI, Lin A, Brinkman JA, Meyer E, Morrison M, Tomasiewicz JL, et al. (2020-07-28).
844:
3819:"Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size"
5956:
5910:
5853:
5413:
5404:
5355:
4121:
3966:
3921:
3719:
Kleinert M, Sylow L, Fazakerley DJ, Krycer JR, Thomas KC, Oxbøll AJ, et al. (September 2014).
3462:
Lamming DW, Mihaylova MM, Katajisto P, Baar EL, Yilmaz OH, Hutchins A, et al. (October 2014).
117:
1916:"Ras suppression potentiates rear actomyosin contractility-driven cell polarization and migration"
1260:
Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, et al. (July 2004).
624:. mTORC2 activation by growth factors is done through promotion of mTORC2-ribosome association in
6141:
5858:
5713:
5136:
3411:
Lamming DW, Demirkan G, Boylan JM, Mihaylova MM, Peng T, Ferreira J, et al. (January 2014).
722:
residues Y1131/1136 and Y1146/1151, respectively, leading to full activation of IGF-IR and InsR.
2102:"mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice"
1967:"mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s"
893:(MLN-0128) have potential in the treatment of this disease and similar fibrotic lung diseases.
666:
mTORC2 also regulates cellular proliferation and metabolism, in part through the regulation of
2151:"Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity"
1965:
Frias MA, Thoreen CC, Jaffe JD, Schroder W, Sculley T, Carr SA, Sabatini DM (September 2006).
907:, and thus inactive mTORC2, have found that mTORC2 plays a critical role in the regulation of
5879:
5798:
4412:
2149:
Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, et al. (March 2012).
2100:
Guertin DA, Stevens DM, Saitoh M, Kinkel S, Crosby K, Sheen JH, et al. (February 2009).
2024:
1564:
Datan E, Shirazian A, Benjamin S, Matassov D, Tinari A, Malorni W, et al. (March 2014).
359:
1859:"Actuation of single downstream nodes in growth factor network steers immune cell migration"
504:
363:
5951:
4979:
3721:"Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo"
3575:
3321:"Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c"
3224:
3165:
3106:
2535:
2476:
2463:
Mullins GR, Wang L, Raje V, Sherwood SG, Grande RC, Boroda S, et al. (December 2014).
2412:
Nagai MH, Xavier VP, Gutiyama LM, Machado CF, Reis AH, Donnard ER, et al. (May 2020).
2368:
2162:
1978:
1381:
1329:
1273:
933:
500:
255:
251:
134:
122:
3211:
Chang W, Wei K, Ho L, Berry GJ, Jacobs SS, Chang CH, Rosen GD (2014-08-27). Mora A (ed.).
2332:
524:
383:
158:
8:
5915:
5088:
3917:
3003:
Guri Y, Colombi M, Dazert E, Hindupur SK, Roszik J, Moes S, et al. (December 2017).
2805:
Masui K, Tanaka K, Akhavan D, Babic I, Gini B, Matsutani T, et al. (November 2013).
2059:
Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF, et al. (April 2006).
1814:
908:
871:
852:
726:
609:
138:
3979:
3579:
3464:"Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan"
3270:
Monteith AJ, Vincent HA, Kang S, Li P, Claiborne TM, Rajfur Z, et al. (July 2018).
3228:
3169:
3110:
2539:
2480:
2372:
2166:
1982:
1891:
1385:
1333:
1277:
1209:
Betz C, Stracka D, Prescianotto-Baschong C, Frieden M, Demaurex N, Hall MN (July 2013).
6131:
5848:
5590:
5544:
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3867:
3843:
3818:
3794:
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3745:
3720:
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3512:
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3439:
3412:
3388:
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3212:
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2582:
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2523:
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2440:
2413:
2389:
2356:
2281:
2256:
2232:
2207:
2183:
2150:
2126:
2101:
2004:
1839:
1782:
1757:
1733:
1708:
1684:
1659:
1635:
1610:
1586:
1565:
1538:
1513:
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1459:
1440:
1353:
1299:
1237:
1210:
1183:
1158:
1134:
1109:
1085:
1060:
1036:
1011:
987:
962:
867:
2905:
Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, et al. (May 2014).
2206:
Liu Q, Chang JW, Wang J, Kang SA, Thoreen CC, Markhard A, et al. (October 2010).
471:
4850:
4559:
3957:
3897:
3848:
3799:
3750:
3701:
3652:
3603:
3544:
3493:
3444:
3393:
3342:
3319:
Hagiwara A, Cornu M, Cybulski N, Polak P, Betz C, Trapani F, et al. (May 2012).
3301:
3252:
3193:
3134:
3075:
3026:
2985:
2936:
2887:
2836:
2787:
2738:
2703:
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2504:
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2337:
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2237:
2188:
2131:
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1996:
1947:
1935:
1915:
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1831:
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1738:
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1640:
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1543:
1489:
1432:
1397:
1345:
1291:
1242:
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1139:
1090:
1041:
992:
920:
795:
1444:
1357:
5894:
5889:
5863:
5791:
4588:
4579:
4509:
4500:
4446:
4437:
4094:
3887:
3879:
3838:
3830:
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3740:
3732:
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3683:
3642:
3634:
3593:
3583:
3534:
3524:
3483:
3475:
3434:
3424:
3383:
3373:
3332:
3291:
3283:
3242:
3232:
3183:
3173:
3124:
3114:
3065:
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3016:
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2926:
2918:
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2818:
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2730:
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2685:
2646:
2602:
2594:
2553:
2543:
2494:
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2435:
2425:
2384:
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2327:
2317:
2276:
2268:
2227:
2219:
2178:
2170:
2121:
2113:
2072:
2033:
2008:
1986:
1943:
1927:
1886:
1870:
1843:
1823:
1777:
1769:
1728:
1720:
1679:
1671:
1630:
1622:
1581:
1573:
1533:
1525:
1479:
1471:
1424:
1389:
1337:
1303:
1281:
1232:
1222:
1178:
1170:
1129:
1121:
1080:
1072:
1031:
1023:
982:
974:
819:
815:
656:
621:
495:
354:
246:
129:
3770:"The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging"
3621:
Kumar A, Lawrence JC, Jung DY, Ko HJ, Keller SR, Kim JK, et al. (June 2010).
2672:
Gan X, Wang J, Wang C, Sommer E, Kozasa T, Srinivasula S, et al. (May 2012).
2524:"Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling"
2355:
Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, Lim D, et al. (June 2011).
5941:
5925:
5838:
5269:
4340:
4335:
4330:
3736:
3670:
Kumar A, Harris TE, Keller SR, Choi KM, Magnuson MA, Lawrence JC (January 2008).
3237:
3178:
3119:
2922:
2756:
Linke M, Fritsch SD, Sukhbaatar N, Hengstschläger M, Weichhart T (October 2017).
2430:
2322:
2305:
2272:
2077:
2060:
1874:
1626:
1393:
1174:
940:
in hypothalamic neurons promotes obesity, frailty, and shorter lifespan in mice.
840:
715:
558:
330:
234:
93:
3021:
3004:
2856:"Weighing In on mTOR Complex 2 Signaling: The Expanding Role in Cell Metabolism"
2734:
1577:
851:
has been linked to promotion of hepatocellular carcinoma through stimulation of
767:, both in cancer cells and normal tissues such as the liver and adipose tissue.
534:
393:
168:
6090:
5979:
5920:
3785:
3568:
Proceedings of the
National Academy of Sciences of the United States of America
3337:
3320:
2822:
2528:
Proceedings of the
National Academy of Sciences of the United States of America
2469:
Proceedings of the
National Academy of Sciences of the United States of America
2037:
1931:
1858:
1812:(2013). "mTOR complexes in neurodevelopmental and neuropsychiatric disorders".
1809:
1215:
Proceedings of the
National Academy of Sciences of the United States of America
1125:
1027:
978:
707:
573:
2971:
2117:
1991:
1966:
1475:
1286:
1261:
1076:
6100:
5884:
5843:
4325:
3413:"Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)"
3287:
2255:
Liu P, Gan W, Chin YR, Ogura K, Guo J, Zhang J, et al. (November 2015).
1939:
1882:
886:
760:
734:
730:
4393:
3588:
3378:
2773:
2548:
2522:
Zhang C, Wendel AA, Keogh MR, Harris TE, Chen J, Coleman RA (January 2012).
2489:
2380:
2174:
1756:
Ebner M, Sinkovics B, Szczygieł M, Ribeiro DW, Yudushkin I (February 2017).
1341:
1227:
5833:
5264:
4089:
3901:
3852:
3803:
3754:
3705:
3656:
3607:
3548:
3497:
3448:
3397:
3346:
3305:
3256:
3197:
3138:
3079:
3030:
2989:
2940:
2891:
2872:
2840:
2791:
2742:
2707:
2658:
2616:
2567:
2508:
2449:
2398:
2341:
2290:
2241:
2192:
2135:
2086:
2045:
2000:
1951:
1900:
1835:
1791:
1742:
1693:
1644:
1595:
1547:
1493:
1436:
1349:
1295:
1246:
1192:
1143:
1094:
1045:
996:
911:. Liver-specific disruption of mTORC2 through hepatic deletion of the gene
890:
856:
636:
629:
577:
2306:"A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation"
1773:
1401:
751:. Mice with reduced mTORC2 have deficient synaptic plasticity and memory.
6057:
5992:
5828:
5470:
5102:
5042:
4925:
4845:
4569:
3687:
3429:
848:
569:
483:
342:
105:
3564:"mTOR complex 2 in adipose tissue negatively controls whole-body growth"
3529:
2630:
Cameron AJ, Linch MD, Saurin AT, Escribano C, Parker PJ (October 2011).
2022:
Bockaert J, Marin P (2015). "mTOR in Brain
Physiology and Pathologies".
1675:
1460:"Mammalian autophagy: core molecular machinery and signaling regulation"
5558:
4032:
3883:
3479:
3046:"New Insights for nicotinamide: Metabolic disease, autophagy, and mTOR"
2650:
1658:
Yin Y, Hua H, Li M, Liu S, Kong Q, Shao T, et al. (January 2016).
1529:
1370:
1208:
478:
337:
100:
3834:
3638:
2598:
2583:"mTORC2 signaling promotes skeletal growth and bone formation in mice"
2223:
1428:
6031:
6005:
4519:
3868:"Hypothalamic mTORC2 is essential for metabolic health and longevity"
1709:"mTOR: from growth signal integration to cancer, diabetes and ageing"
866:, chronic rapamycin treatment abrogates mTORC2 signaling, leading to
863:
803:
780:
703:
691:
660:
554:
2755:
2689:
2061:"Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB"
1827:
1724:
1609:
Arias E, Koga H, Diaz A, Mocholi E, Patel B, Cuervo AM (July 2015).
600:), mammalian stress-activated protein kinase interacting protein 1 (
6085:
4875:
4770:
4765:
4760:
2257:"PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex"
1611:"Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy"
1059:
Chen X, Liu M, Tian Y, Li J, Qi Y, Zhao D, et al. (May 2018).
719:
699:
640:
4235:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
3865:
5534:
5512:
5507:
5497:
5492:
5294:
5289:
5284:
5279:
5274:
5259:
5254:
4905:
4870:
4109:
4104:
4099:
3061:
1110:"The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation"
768:
748:
633:
601:
423:
408:
2758:"mTORC1 and mTORC2 as regulators of cell metabolism in immunity"
459:
318:
81:
6044:
5814:
5764:
5759:
5754:
5749:
5744:
5739:
5734:
5685:
5680:
5675:
5670:
5665:
5648:
5643:
5517:
5502:
5453:
5448:
5433:
5428:
5423:
5418:
5392:
5387:
5382:
5370:
5348:
5343:
5235:
5210:
4885:
4710:
4705:
4700:
4695:
4680:
4524:
4461:
4456:
4451:
4427:
4253:
4248:
4222:
4217:
4212:
4202:
4197:
4187:
4027:
3958:
2632:"mTORC2 targets AGC kinases through Sin1-dependent recruitment"
919:
may protect from a high-fat diet in young mice, but results in
741:
718:
activity and phosphorylates IGF-IR and insulin receptor at the
687:
597:
593:
581:
466:
325:
229:
198:
183:
88:
3562:
Cybulski N, Polak P, Auwerx J, Rüegg MA, Hall MN (June 2009).
3410:
1755:
1563:
6018:
5660:
5653:
5563:
5460:
5360:
5338:
5333:
5328:
5323:
5318:
5230:
5225:
5220:
5215:
5205:
5175:
5155:
5032:
5027:
5008:
5003:
4993:
4969:
4964:
4959:
4935:
4930:
4920:
4915:
4910:
4900:
4880:
4865:
4860:
4855:
4835:
4830:
4820:
4815:
4810:
4805:
4800:
4790:
4785:
4780:
4775:
4755:
4750:
4745:
4740:
4735:
4730:
4715:
4665:
4660:
4554:
4549:
4544:
4539:
4534:
4529:
4490:
4422:
4417:
4366:
4361:
4287:
4282:
4277:
4243:
4037:
4022:
4017:
4012:
4007:
4002:
3718:
3510:
3461:
3151:
799:
745:
695:
667:
652:
589:
585:
282:
267:
3817:
Gu Y, Lindner J, Kumar A, Yuan W, Magnuson MA (March 2011).
2904:
2581:
Chen J, Holguin N, Shi Y, Silva MJ, Long F (February 2015).
885:
The mTORC2 pathways plays a crucial role in pathogenesis of
682:. mTORC2 phosphorylates the serine/threonine protein kinase
5553:
5480:
5475:
5465:
5438:
5195:
5145:
5126:
5121:
5116:
5111:
5066:
5061:
5056:
5051:
4998:
4954:
4895:
4890:
4840:
4825:
4795:
4725:
4641:
4636:
4631:
4564:
4466:
4407:
4402:
4306:
4272:
4157:
4152:
4147:
4116:
4084:
4072:
4067:
4062:
4052:
4047:
3360:
Yuan M, Pino E, Wu L, Kacergis M, Soukas AA (August 2012).
2720:
2629:
2304:
Yang G, Murashige DS, Humphrey SJ, James DE (August 2015).
2148:
1511:
1319:
827:
823:
784:
671:
648:
644:
625:
565:
5783:
3318:
3154:"Haploinsufficiency of akt1 prolongs the lifespan of mice"
2411:
2303:
2099:
5522:
4057:
4042:
3213:"A critical role for the mTORC2 pathway in lung fibrosis"
3002:
2058:
1964:
683:
679:
675:
5712:
3561:
2956:"mTORC2 in the center of cancer metabolic reprogramming"
1856:
678:
and the serum-and glucocorticoid-induced protein kinase
2804:
2462:
1807:
2521:
2414:"Depletion of Ric-8B leads to reduced mTORC2 activity"
1913:
1259:
6074:
3669:
3269:
2354:
1608:
3620:
3092:
3005:"mTORC2 Promotes Tumorigenesis via Lipid Synthesis"
2953:
2580:
1706:
963:"mTOR Signaling in Growth, Metabolism, and Disease"
3816:
3359:
1512:Ballesteros-Álvarez J, Andersen JK (August 2021).
2671:
1414:
1159:"Growing knowledge of the mTOR signaling network"
6098:
2205:
1651:
1514:"mTORC2: The other mTOR in autophagy regulation"
1009:
903:Studies using mice with tissue-specific loss of
798:loop between mTORC1 and insulin/PI3K signaling.
3210:
2254:
1803:
1801:
1707:Zoncu R, Efeyan A, Sabatini DM (January 2011).
1107:
3767:
1758:"Localization of mTORC2 activity inside cells"
1315:
1313:
1012:"mTOR signaling in growth control and disease"
960:
956:
954:
952:
5799:
3994:Non-specific serine/threonine protein kinases
3943:
3093:Mason JS, Wileman T, Chapman T (2018-01-12).
2954:Masui K, Cavenee WK, Mischel PS (July 2014).
2021:
1058:
889:, and inhibitors of its active site such as
604:), and protein observed with rictor 1 and 2 (
3037:
2093:
2015:
1798:
1700:
1457:
1163:Seminars in Cell & Developmental Biology
1657:
1310:
1204:
1202:
1156:
1101:
1061:"Cryo-EM structure of human mTOR complex 2"
949:
896:Chronic mTORC2 activity may play a role in
754:
596:. Rapamycin-insensitive companion of mTOR (
584:), mammalian lethal with sec-13 protein 8 (
5806:
5792:
4377:Goodpasture-antigen-binding protein kinase
3950:
3936:
2853:
862:Although mTORC2 is acutely insensitive to
5090:Serine/threonine-specific protein kinases
4264:(isocitrate dehydrogenase (NADP+)) kinase
3981:Serine/threonine-specific protein kinases
3963:Serine/threonine-specific protein kinases
3920:at the U.S. National Library of Medicine
3891:
3842:
3793:
3744:
3695:
3646:
3597:
3587:
3538:
3528:
3487:
3438:
3428:
3387:
3377:
3336:
3295:
3246:
3236:
3187:
3177:
3128:
3118:
3069:
3020:
2979:
2930:
2881:
2871:
2860:Oxidative Medicine and Cellular Longevity
2830:
2781:
2697:
2606:
2557:
2547:
2498:
2488:
2439:
2429:
2388:
2331:
2321:
2280:
2231:
2182:
2125:
2076:
1990:
1890:
1781:
1732:
1683:
1634:
1585:
1537:
1483:
1285:
1236:
1226:
1182:
1133:
1108:Mendoza MC, Er EE, Blenis J (June 2011).
1084:
1035:
986:
5625:Receptor protein serine/threonine kinase
1559:
1557:
1199:
1003:
5608:Low-density-lipoprotein receptor kinase
2854:Luo Y, Xu W, Li G, Cui W (2018-10-30).
1408:
1364:
809:
6099:
3043:
2960:Trends in Endocrinology and Metabolism
1713:Nature Reviews. Molecular Cell Biology
1010:Laplante M, Sabatini DM (April 2012).
592:complex are shared by both mTORC2 and
5787:
5711:
5087:
4353:Fas-activated serine/threonine kinase
3978:
3931:
2052:
1958:
1602:
1554:
1507:
1505:
1503:
961:Saxton RA, Sabatini DM (March 2017).
774:
5725:
5634:Bone morphogenetic protein receptors
3768:Kennedy BK, Lamming DW (June 2016).
2587:Journal of Bone and Mineral Research
1253:
1157:Huang K, Fingar DC (December 2014).
771:can also be used to inhibit mTORC2.
744:and neutrophils, mTORC2 facilitates
4168:Dephospho-(reductase kinase) kinase
3366:The Journal of Biological Chemistry
2199:
13:
4623:G-protein coupled receptor kinases
1500:
1458:Yang Z, Klionsky DJ (April 2010).
833:
698:and leads to full Akt activation.
14:
6153:
4613:Beta adrenergic receptor kinase-2
4298:(tyrosine 3-monooxygenase) kinase
3911:
2723:Advances in Biological Regulation
1572:. 452–453 (March 2014): 175–190.
6084:
5305:Mitogen-activated protein kinase
900:by impairing lysosome function.
5691:Anti-Müllerian hormone receptor
5574:(acetyl-CoA carboxylase) kinase
5246:(RNA-polymerase)-subunit kinase
4608:Beta adrenergic receptor kinase
4599:Beta adrenergic receptor kinase
3859:
3810:
3761:
3712:
3663:
3614:
3555:
3504:
3455:
3404:
3353:
3312:
3263:
3204:
3145:
3086:
2996:
2947:
2898:
2847:
2798:
2749:
2714:
2665:
2623:
2574:
2515:
2456:
2405:
2348:
2297:
2248:
2142:
1907:
1850:
1749:
1464:Current Opinion in Cell Biology
1451:
1417:International Journal of Cancer
588:, also known as GβL), and TTI1/
5314:Extracellular signal-regulated
3676:Molecular and Cellular Biology
2333:11858/00-001M-0000-0028-463C-B
2212:Journal of Medicinal Chemistry
1150:
1114:Trends in Biochemical Sciences
1052:
1:
5378:P38 mitogen-activated protein
4477:cGMP-dependent protein kinase
4438:cAMP-dependent protein kinase
4134:Pyruvate dehydrogenase kinase
4080:Ataxia telangiectasia mutated
943:
6117:Genes on human chromosome 16
4177:AMP-activated protein kinase
3737:10.1016/j.molmet.2014.06.004
3238:10.1371/journal.pone.0106155
3179:10.1371/journal.pone.0069178
3120:10.1371/journal.pone.0190105
2923:10.1158/2159-8290.CD-13-0929
2431:10.1371/journal.pgen.1008255
2323:10.1016/j.celrep.2015.07.016
2273:10.1158/2159-8290.CD-15-0460
2078:10.1016/j.molcel.2006.03.029
1875:10.1016/j.devcel.2023.04.019
1627:10.1016/j.molcel.2015.05.030
1394:10.1126/science.279.5351.710
1175:10.1016/j.semcdb.2014.09.011
898:systemic lupus erythematosus
712:chaperone-mediated autophagy
7:
6122:Genes on human chromosome 9
6112:Genes on human chromosome 5
6107:Genes on human chromosome 1
5813:
5092:(EC 2.7.11.21-EC 2.7.11.30)
3022:10.1016/j.ccell.2017.11.011
2735:10.1016/j.jbior.2016.12.001
1762:The Journal of Cell Biology
1578:10.1016/j.virol.2014.01.008
714:). In addition, mTORC2 has
632:through its stimulation of
615:
10:
6158:
5019:Elongation factor 2 kinase
3983:(EC 2.7.11.1-EC 2.7.11.20)
3786:10.1016/j.cmet.2016.05.009
3338:10.1016/j.cmet.2012.03.015
2823:10.1016/j.cmet.2013.09.013
2038:10.1152/physrev.00038.2014
1932:10.1038/s41556-024-01453-4
1126:10.1016/j.tibs.2011.03.006
1028:10.1016/j.cell.2012.03.017
979:10.1016/j.cell.2017.02.004
5970:
5962:Michaelis–Menten kinetics
5934:
5903:
5872:
5821:
5721:
5707:
5623:
5606:
5589:
5572:
5543:
5414:MAP kinase kinase kinases
5403:
5303:
5244:
5135:
5101:
5097:
5083:
5041:
5017:
4978:
4946:Myosin light-chain kinase
4944:
4652:Ca2+/calmodulin-dependent
4650:
4621:
4597:
4578:
4499:
4475:
4436:
4392:
4375:
4351:
4317:Myosin-heavy-chain kinase
4315:
4296:
4262:
4233:
4166:
4132:
3992:
3988:
3974:
2972:10.1016/j.tem.2014.04.002
2118:10.1016/j.ccr.2008.12.017
1992:10.1016/j.cub.2006.08.001
1476:10.1016/j.ceb.2009.11.014
1287:10.1016/j.cub.2004.06.054
1077:10.1038/s41422-018-0029-3
530:
520:
515:
511:
494:
489:
477:
465:
453:
441:
429:
419:
414:
407:
389:
379:
374:
370:
353:
348:
336:
324:
312:
300:
288:
278:
273:
266:
245:
240:
228:
216:
204:
194:
189:
182:
164:
154:
149:
145:
128:
116:
111:
99:
87:
75:
63:
51:
43:
33:
28:
21:
5854:Diffusion-limited enzyme
5714:Dual-specificity kinases
3922:Medical Subject Headings
3288:10.4049/jimmunol.1701712
841:type 2 diabetes mellitus
755:Regulation and signaling
5137:Cyclin-dependent kinase
3589:10.1073/pnas.0811321106
3379:10.1074/jbc.M112.386854
3050:Frontiers in Bioscience
2774:10.1002/1873-3468.12711
2639:The Biochemical Journal
2549:10.1073/pnas.1110730109
2490:10.1073/pnas.1410530111
2381:10.1126/science.1199498
2175:10.1126/science.1215135
1342:10.1126/science.1106148
1228:10.1073/pnas.1302455110
563:serine/threonine kinase
3044:Maiese K (June 2020).
6137:Tor signaling pathway
5947:Eadie–Hofstee diagram
5880:Allosteric regulation
3276:Journal of Immunology
2025:Physiological Reviews
1774:10.1083/jcb.201610060
934:pancreatic beta cells
5957:Lineweaver–Burk plot
4980:Phosphorylase kinase
3725:Molecular Metabolism
3688:10.1128/MCB.01405-07
3430:10.1096/fj.13-237743
2873:10.1155/2018/7838647
1869:(13): 1170–1188.e7.
810:Downstream signaling
3580:2009PNAS..106.9902C
3530:10.7554/eLife.56177
3229:2014PLoSO...9j6155C
3170:2013PLoSO...869178N
3111:2018PLoSO..1390105M
2678:Nature Cell Biology
2540:2012PNAS..109.1667Z
2481:2014PNAS..11117450M
2373:2011Sci...332.1317H
2167:2012Sci...335.1638L
1983:2006CBio...16.1865F
1920:Nature Cell Biology
1815:Nature Neuroscience
1676:10.1038/cr.2015.133
1386:1998Sci...279..710S
1334:2005Sci...307.1098S
1278:2004CBio...14.1296D
909:glucose homeostasis
872:glucose intolerance
853:glycerophospholipid
5916:Enzyme superfamily
5849:Enzyme promiscuity
5591:Tropomyosin kinase
5545:Tau-protein kinase
3884:10.1111/acel.13014
3480:10.1111/acel.12256
3015:(6): 807–823.e12.
2651:10.1042/BJ20110678
1863:Developmental Cell
1808:Costa-Mattioli M,
1530:10.1111/acel.13431
1328:(5712): 1098–101.
868:insulin resistance
847:. mTORC2-mediated
775:Upstream signaling
570:cell proliferation
47:FRAP, FRAP2, FRAP1
6127:Protein complexes
6072:
6071:
5781:
5780:
5777:
5776:
5773:
5772:
5703:
5702:
5699:
5698:
5079:
5078:
5075:
5074:
4560:Protein kinase N1
4515:Protein kinase Cζ
3835:10.2337/db10-1194
3639:10.2337/db09-1061
3056:(11): 1925–1973.
2768:(19): 3089–3103.
2599:10.1002/jbmr.2348
2367:(6035): 1317–22.
2224:10.1021/jm101144f
2161:(6076): 1638–43.
1822:(11): 1537–1543.
1429:10.1002/ijc.21932
921:hepatic steatosis
796:negative feedback
544:
543:
540:
539:
403:
402:
399:
398:
262:
261:
178:
177:
174:
173:
6149:
6089:
6088:
6080:
5952:Hanes–Woolf plot
5895:Enzyme activator
5890:Enzyme inhibitor
5864:Enzyme catalysis
5808:
5801:
5794:
5785:
5784:
5723:
5722:
5709:
5708:
5356:C-Jun N-terminal
5099:
5098:
5085:
5084:
4589:Rhodopsin kinase
4580:Rhodopsin kinase
4510:Protein kinase C
4501:Protein kinase C
4486:Protein kinase G
4447:Protein kinase A
4058:Protein kinase B
3990:
3989:
3976:
3975:
3952:
3945:
3938:
3929:
3928:
3906:
3905:
3895:
3863:
3857:
3856:
3846:
3814:
3808:
3807:
3797:
3765:
3759:
3758:
3748:
3716:
3710:
3709:
3699:
3667:
3661:
3660:
3650:
3618:
3612:
3611:
3601:
3591:
3559:
3553:
3552:
3542:
3532:
3508:
3502:
3501:
3491:
3459:
3453:
3452:
3442:
3432:
3408:
3402:
3401:
3391:
3381:
3372:(35): 29579–88.
3357:
3351:
3350:
3340:
3316:
3310:
3309:
3299:
3267:
3261:
3260:
3250:
3240:
3208:
3202:
3201:
3191:
3181:
3149:
3143:
3142:
3132:
3122:
3090:
3084:
3083:
3073:
3041:
3035:
3034:
3024:
3000:
2994:
2993:
2983:
2951:
2945:
2944:
2934:
2911:Cancer Discovery
2902:
2896:
2895:
2885:
2875:
2851:
2845:
2844:
2834:
2802:
2796:
2795:
2785:
2753:
2747:
2746:
2718:
2712:
2711:
2701:
2669:
2663:
2662:
2636:
2627:
2621:
2620:
2610:
2578:
2572:
2571:
2561:
2551:
2519:
2513:
2512:
2502:
2492:
2460:
2454:
2453:
2443:
2433:
2409:
2403:
2402:
2392:
2352:
2346:
2345:
2335:
2325:
2301:
2295:
2294:
2284:
2267:(11): 1194–209.
2261:Cancer Discovery
2252:
2246:
2245:
2235:
2203:
2197:
2196:
2186:
2146:
2140:
2139:
2129:
2097:
2091:
2090:
2080:
2056:
2050:
2049:
2032:(4): 1157–1187.
2019:
2013:
2012:
1994:
1962:
1956:
1955:
1946: 11364469.
1926:(7): 1062–1076.
1911:
1905:
1904:
1894:
1854:
1848:
1847:
1805:
1796:
1795:
1785:
1753:
1747:
1746:
1736:
1704:
1698:
1697:
1687:
1655:
1649:
1648:
1638:
1606:
1600:
1599:
1589:
1561:
1552:
1551:
1541:
1509:
1498:
1497:
1487:
1455:
1449:
1448:
1412:
1406:
1405:
1368:
1362:
1361:
1317:
1308:
1307:
1289:
1272:(14): 1296–302.
1257:
1251:
1250:
1240:
1230:
1221:(31): 12526–34.
1206:
1197:
1196:
1186:
1154:
1148:
1147:
1137:
1105:
1099:
1098:
1088:
1056:
1050:
1049:
1039:
1007:
1001:
1000:
990:
958:
694:T308 residue by
657:protein kinase C
553:) is an acutely
513:
512:
405:
404:
372:
371:
264:
263:
180:
179:
147:
146:
19:
18:
6157:
6156:
6152:
6151:
6150:
6148:
6147:
6146:
6097:
6096:
6095:
6083:
6075:
6073:
6068:
5980:Oxidoreductases
5966:
5942:Enzyme kinetics
5930:
5926:List of enzymes
5899:
5868:
5839:Catalytic triad
5817:
5812:
5782:
5769:
5717:
5695:
5619:
5602:
5585:
5568:
5539:
5399:
5299:
5270:P70-S6 Kinase 1
5240:
5131:
5093:
5071:
5037:
5013:
4974:
4940:
4646:
4617:
4593:
4574:
4495:
4471:
4432:
4388:
4371:
4347:
4341:Aurora C kinase
4336:Aurora B kinase
4331:Aurora A kinase
4311:
4292:
4258:
4229:
4162:
4128:
3984:
3970:
3956:
3914:
3909:
3864:
3860:
3815:
3811:
3780:(6): 990–1003.
3774:Cell Metabolism
3766:
3762:
3717:
3713:
3668:
3664:
3633:(6): 1397–406.
3619:
3615:
3560:
3556:
3509:
3505:
3460:
3456:
3409:
3405:
3358:
3354:
3325:Cell Metabolism
3317:
3313:
3268:
3264:
3209:
3205:
3150:
3146:
3105:(1): e0190105.
3091:
3087:
3042:
3038:
3001:
2997:
2952:
2948:
2903:
2899:
2852:
2848:
2811:Cell Metabolism
2803:
2799:
2754:
2750:
2719:
2715:
2690:10.1038/ncb2507
2670:
2666:
2634:
2628:
2624:
2579:
2575:
2520:
2516:
2475:(49): 17450–5.
2461:
2457:
2424:(5): e1008255.
2410:
2406:
2353:
2349:
2302:
2298:
2253:
2249:
2218:(19): 7146–55.
2204:
2200:
2147:
2143:
2098:
2094:
2057:
2053:
2020:
2016:
1977:(18): 1865–70.
1971:Current Biology
1963:
1959:
1912:
1908:
1855:
1851:
1828:10.1038/nn.3546
1806:
1799:
1754:
1750:
1725:10.1038/nrm3025
1705:
1701:
1656:
1652:
1607:
1603:
1562:
1555:
1510:
1501:
1456:
1452:
1413:
1409:
1380:(5351): 710–4.
1369:
1365:
1318:
1311:
1266:Current Biology
1258:
1254:
1207:
1200:
1155:
1151:
1106:
1102:
1057:
1053:
1008:
1004:
959:
950:
946:
836:
834:Role in disease
812:
788:
777:
757:
735:plasma membrane
716:tyrosine kinase
618:
568:that regulates
559:protein complex
17:
16:Protein complex
12:
11:
5:
6155:
6145:
6144:
6142:Human proteins
6139:
6134:
6129:
6124:
6119:
6114:
6109:
6094:
6093:
6070:
6069:
6067:
6066:
6053:
6040:
6027:
6014:
6001:
5988:
5974:
5972:
5968:
5967:
5965:
5964:
5959:
5954:
5949:
5944:
5938:
5936:
5932:
5931:
5929:
5928:
5923:
5918:
5913:
5907:
5905:
5904:Classification
5901:
5900:
5898:
5897:
5892:
5887:
5882:
5876:
5874:
5870:
5869:
5867:
5866:
5861:
5856:
5851:
5846:
5841:
5836:
5831:
5825:
5823:
5819:
5818:
5811:
5810:
5803:
5796:
5788:
5779:
5778:
5775:
5774:
5771:
5770:
5768:
5767:
5762:
5757:
5752:
5747:
5742:
5737:
5731:
5729:
5719:
5718:
5705:
5704:
5701:
5700:
5697:
5696:
5694:
5693:
5688:
5683:
5678:
5673:
5668:
5663:
5658:
5657:
5656:
5651:
5646:
5641:
5630:
5628:
5627:(EC 2.7.11.30)
5621:
5620:
5618:
5617:
5613:
5611:
5610:(EC 2.7.11.29)
5604:
5603:
5601:
5600:
5596:
5594:
5593:(EC 2.7.11.28)
5587:
5586:
5584:
5583:
5579:
5577:
5576:(EC 2.7.11.27)
5570:
5569:
5567:
5566:
5561:
5556:
5550:
5548:
5547:(EC 2.7.11.26)
5541:
5540:
5538:
5537:
5532:
5527:
5526:
5525:
5520:
5515:
5510:
5505:
5500:
5495:
5485:
5484:
5483:
5478:
5473:
5468:
5458:
5457:
5456:
5451:
5446:
5441:
5436:
5431:
5426:
5421:
5410:
5408:
5407:(EC 2.7.11.25)
5401:
5400:
5398:
5397:
5396:
5395:
5390:
5385:
5375:
5374:
5373:
5368:
5363:
5353:
5352:
5351:
5346:
5341:
5336:
5331:
5326:
5321:
5310:
5308:
5307:(EC 2.7.11.24)
5301:
5300:
5298:
5297:
5292:
5287:
5282:
5277:
5272:
5267:
5262:
5257:
5251:
5249:
5248:(EC 2.7.11.23)
5242:
5241:
5239:
5238:
5233:
5228:
5223:
5218:
5213:
5208:
5203:
5198:
5193:
5188:
5183:
5178:
5173:
5168:
5163:
5158:
5153:
5148:
5142:
5140:
5139:(EC 2.7.11.22)
5133:
5132:
5130:
5129:
5124:
5119:
5114:
5108:
5106:
5105:(EC 2.7.11.21)
5095:
5094:
5081:
5080:
5077:
5076:
5073:
5072:
5070:
5069:
5064:
5059:
5054:
5048:
5046:
5045:(EC 2.7.11.21)
5039:
5038:
5036:
5035:
5030:
5024:
5022:
5021:(EC 2.7.11.20)
5015:
5014:
5012:
5011:
5006:
5001:
4996:
4991:
4985:
4983:
4982:(EC 2.7.11.19)
4976:
4975:
4973:
4972:
4967:
4962:
4957:
4951:
4949:
4948:(EC 2.7.11.18)
4942:
4941:
4939:
4938:
4933:
4928:
4923:
4918:
4913:
4908:
4903:
4898:
4893:
4888:
4883:
4878:
4873:
4868:
4863:
4858:
4853:
4848:
4843:
4838:
4833:
4828:
4823:
4818:
4813:
4808:
4803:
4798:
4793:
4788:
4783:
4778:
4773:
4768:
4763:
4758:
4753:
4748:
4743:
4738:
4733:
4728:
4723:
4718:
4713:
4708:
4703:
4698:
4693:
4688:
4683:
4678:
4673:
4668:
4663:
4657:
4655:
4654:(EC 2.7.11.17)
4648:
4647:
4645:
4644:
4639:
4634:
4628:
4626:
4625:(EC 2.7.11.16)
4619:
4618:
4616:
4615:
4610:
4604:
4602:
4601:(EC 2.7.11.15)
4595:
4594:
4592:
4591:
4585:
4583:
4582:(EC 2.7.11.14)
4576:
4575:
4573:
4572:
4567:
4562:
4557:
4552:
4547:
4542:
4537:
4532:
4527:
4522:
4517:
4512:
4506:
4504:
4503:(EC 2.7.11.13)
4497:
4496:
4494:
4493:
4488:
4482:
4480:
4479:(EC 2.7.11.12)
4473:
4472:
4470:
4469:
4464:
4459:
4454:
4449:
4443:
4441:
4440:(EC 2.7.11.11)
4434:
4433:
4431:
4430:
4425:
4420:
4415:
4410:
4405:
4399:
4397:
4396:(EC 2.7.11.10)
4390:
4389:
4387:
4386:
4382:
4380:
4373:
4372:
4370:
4369:
4364:
4358:
4356:
4349:
4348:
4346:
4345:
4344:
4343:
4338:
4333:
4322:
4320:
4313:
4312:
4310:
4309:
4303:
4301:
4294:
4293:
4291:
4290:
4285:
4280:
4275:
4269:
4267:
4260:
4259:
4257:
4256:
4251:
4246:
4240:
4238:
4231:
4230:
4228:
4227:
4226:
4225:
4220:
4215:
4207:
4206:
4205:
4200:
4192:
4191:
4190:
4185:
4173:
4171:
4164:
4163:
4161:
4160:
4155:
4150:
4145:
4139:
4137:
4130:
4129:
4127:
4126:
4125:
4124:
4114:
4113:
4112:
4107:
4102:
4097:
4087:
4082:
4077:
4076:
4075:
4070:
4065:
4055:
4050:
4045:
4040:
4035:
4030:
4025:
4020:
4015:
4010:
4005:
3999:
3997:
3986:
3985:
3972:
3971:
3955:
3954:
3947:
3940:
3932:
3926:
3925:
3913:
3912:External links
3910:
3908:
3907:
3858:
3809:
3760:
3711:
3662:
3613:
3574:(24): 9902–7.
3554:
3503:
3454:
3403:
3352:
3311:
3282:(2): 371–382.
3262:
3223:(8): e106155.
3203:
3144:
3085:
3036:
2995:
2946:
2897:
2846:
2797:
2748:
2713:
2664:
2622:
2573:
2534:(5): 1667–72.
2514:
2455:
2404:
2347:
2296:
2247:
2198:
2141:
2092:
2065:Molecular Cell
2051:
2014:
1957:
1906:
1849:
1797:
1768:(2): 343–353.
1748:
1699:
1650:
1615:Molecular Cell
1601:
1553:
1499:
1450:
1407:
1363:
1309:
1252:
1198:
1149:
1100:
1071:(5): 518–528.
1051:
1002:
973:(6): 960–976.
947:
945:
942:
845:Warburg effect
835:
832:
811:
808:
786:
776:
773:
761:growth factors
756:
753:
749:polymerization
708:macroautophagy
617:
614:
574:cell migration
572:and survival,
547:mTOR Complex 2
542:
541:
538:
537:
532:
528:
527:
522:
518:
517:
509:
508:
498:
492:
491:
487:
486:
481:
475:
474:
472:NM_001006617.1
469:
463:
462:
457:
451:
450:
445:
439:
438:
433:
427:
426:
421:
417:
416:
412:
411:
401:
400:
397:
396:
391:
387:
386:
381:
377:
376:
368:
367:
357:
351:
350:
346:
345:
340:
334:
333:
328:
322:
321:
316:
310:
309:
304:
298:
297:
292:
286:
285:
280:
276:
275:
271:
270:
260:
259:
249:
243:
242:
238:
237:
232:
226:
225:
220:
214:
213:
208:
202:
201:
196:
192:
191:
187:
186:
176:
175:
172:
171:
166:
162:
161:
156:
152:
151:
143:
142:
132:
126:
125:
120:
114:
113:
109:
108:
103:
97:
96:
91:
85:
84:
79:
73:
72:
67:
61:
60:
55:
49:
48:
45:
41:
40:
35:
31:
30:
26:
25:
15:
9:
6:
4:
3:
2:
6154:
6143:
6140:
6138:
6135:
6133:
6130:
6128:
6125:
6123:
6120:
6118:
6115:
6113:
6110:
6108:
6105:
6104:
6102:
6092:
6087:
6082:
6081:
6078:
6064:
6060:
6059:
6054:
6051:
6047:
6046:
6041:
6038:
6034:
6033:
6028:
6025:
6021:
6020:
6015:
6012:
6008:
6007:
6002:
5999:
5995:
5994:
5989:
5986:
5982:
5981:
5976:
5975:
5973:
5969:
5963:
5960:
5958:
5955:
5953:
5950:
5948:
5945:
5943:
5940:
5939:
5937:
5933:
5927:
5924:
5922:
5921:Enzyme family
5919:
5917:
5914:
5912:
5909:
5908:
5906:
5902:
5896:
5893:
5891:
5888:
5886:
5885:Cooperativity
5883:
5881:
5878:
5877:
5875:
5871:
5865:
5862:
5860:
5857:
5855:
5852:
5850:
5847:
5845:
5844:Oxyanion hole
5842:
5840:
5837:
5835:
5832:
5830:
5827:
5826:
5824:
5820:
5816:
5809:
5804:
5802:
5797:
5795:
5790:
5789:
5786:
5766:
5763:
5761:
5758:
5756:
5753:
5751:
5748:
5746:
5743:
5741:
5738:
5736:
5733:
5732:
5730:
5728:
5724:
5720:
5715:
5710:
5706:
5692:
5689:
5687:
5684:
5682:
5679:
5677:
5674:
5672:
5669:
5667:
5664:
5662:
5659:
5655:
5652:
5650:
5647:
5645:
5642:
5640:
5637:
5636:
5635:
5632:
5631:
5629:
5626:
5622:
5615:
5614:
5612:
5609:
5605:
5598:
5597:
5595:
5592:
5588:
5581:
5580:
5578:
5575:
5571:
5565:
5562:
5560:
5557:
5555:
5552:
5551:
5549:
5546:
5542:
5536:
5533:
5531:
5528:
5524:
5521:
5519:
5516:
5514:
5511:
5509:
5506:
5504:
5501:
5499:
5496:
5494:
5491:
5490:
5489:
5486:
5482:
5479:
5477:
5474:
5472:
5469:
5467:
5464:
5463:
5462:
5459:
5455:
5452:
5450:
5447:
5445:
5442:
5440:
5437:
5435:
5432:
5430:
5427:
5425:
5422:
5420:
5417:
5416:
5415:
5412:
5411:
5409:
5406:
5402:
5394:
5391:
5389:
5386:
5384:
5381:
5380:
5379:
5376:
5372:
5369:
5367:
5364:
5362:
5359:
5358:
5357:
5354:
5350:
5347:
5345:
5342:
5340:
5337:
5335:
5332:
5330:
5327:
5325:
5322:
5320:
5317:
5316:
5315:
5312:
5311:
5309:
5306:
5302:
5296:
5293:
5291:
5288:
5286:
5283:
5281:
5278:
5276:
5273:
5271:
5268:
5266:
5263:
5261:
5258:
5256:
5253:
5252:
5250:
5247:
5243:
5237:
5234:
5232:
5229:
5227:
5224:
5222:
5219:
5217:
5214:
5212:
5209:
5207:
5204:
5202:
5199:
5197:
5194:
5192:
5189:
5187:
5184:
5182:
5179:
5177:
5174:
5172:
5169:
5167:
5164:
5162:
5159:
5157:
5154:
5152:
5149:
5147:
5144:
5143:
5141:
5138:
5134:
5128:
5125:
5123:
5120:
5118:
5115:
5113:
5110:
5109:
5107:
5104:
5100:
5096:
5091:
5086:
5082:
5068:
5065:
5063:
5060:
5058:
5055:
5053:
5050:
5049:
5047:
5044:
5040:
5034:
5031:
5029:
5026:
5025:
5023:
5020:
5016:
5010:
5007:
5005:
5002:
5000:
4997:
4995:
4992:
4990:
4987:
4986:
4984:
4981:
4977:
4971:
4968:
4966:
4963:
4961:
4958:
4956:
4953:
4952:
4950:
4947:
4943:
4937:
4934:
4932:
4929:
4927:
4924:
4922:
4919:
4917:
4914:
4912:
4909:
4907:
4904:
4902:
4899:
4897:
4894:
4892:
4889:
4887:
4884:
4882:
4879:
4877:
4874:
4872:
4869:
4867:
4864:
4862:
4859:
4857:
4854:
4852:
4849:
4847:
4844:
4842:
4839:
4837:
4834:
4832:
4829:
4827:
4824:
4822:
4819:
4817:
4814:
4812:
4809:
4807:
4804:
4802:
4799:
4797:
4794:
4792:
4789:
4787:
4784:
4782:
4779:
4777:
4774:
4772:
4769:
4767:
4764:
4762:
4759:
4757:
4754:
4752:
4749:
4747:
4744:
4742:
4739:
4737:
4734:
4732:
4729:
4727:
4724:
4722:
4719:
4717:
4714:
4712:
4709:
4707:
4704:
4702:
4699:
4697:
4694:
4692:
4689:
4687:
4684:
4682:
4679:
4677:
4674:
4672:
4669:
4667:
4664:
4662:
4659:
4658:
4656:
4653:
4649:
4643:
4640:
4638:
4635:
4633:
4630:
4629:
4627:
4624:
4620:
4614:
4611:
4609:
4606:
4605:
4603:
4600:
4596:
4590:
4587:
4586:
4584:
4581:
4577:
4571:
4568:
4566:
4563:
4561:
4558:
4556:
4553:
4551:
4548:
4546:
4543:
4541:
4538:
4536:
4533:
4531:
4528:
4526:
4523:
4521:
4518:
4516:
4513:
4511:
4508:
4507:
4505:
4502:
4498:
4492:
4489:
4487:
4484:
4483:
4481:
4478:
4474:
4468:
4465:
4463:
4460:
4458:
4455:
4453:
4450:
4448:
4445:
4444:
4442:
4439:
4435:
4429:
4426:
4424:
4421:
4419:
4416:
4414:
4411:
4409:
4406:
4404:
4401:
4400:
4398:
4395:
4391:
4384:
4383:
4381:
4379:(EC 2.7.11.9)
4378:
4374:
4368:
4365:
4363:
4360:
4359:
4357:
4355:(EC 2.7.11.8)
4354:
4350:
4342:
4339:
4337:
4334:
4332:
4329:
4328:
4327:
4326:Aurora kinase
4324:
4323:
4321:
4319:(EC 2.7.11.7)
4318:
4314:
4308:
4305:
4304:
4302:
4300:(EC 2.7.11.6)
4299:
4295:
4289:
4286:
4284:
4281:
4279:
4276:
4274:
4271:
4270:
4268:
4266:(EC 2.7.11.5)
4265:
4261:
4255:
4252:
4250:
4247:
4245:
4242:
4241:
4239:
4237:(EC 2.7.11.4)
4236:
4232:
4224:
4221:
4219:
4216:
4214:
4211:
4210:
4208:
4204:
4201:
4199:
4196:
4195:
4193:
4189:
4186:
4184:
4181:
4180:
4178:
4175:
4174:
4172:
4170:(EC 2.7.11.3)
4169:
4165:
4159:
4156:
4154:
4151:
4149:
4146:
4144:
4141:
4140:
4138:
4136:(EC 2.7.11.2)
4135:
4131:
4123:
4120:
4119:
4118:
4115:
4111:
4108:
4106:
4103:
4101:
4098:
4096:
4093:
4092:
4091:
4090:EIF-2 kinases
4088:
4086:
4083:
4081:
4078:
4074:
4071:
4069:
4066:
4064:
4061:
4060:
4059:
4056:
4054:
4051:
4049:
4046:
4044:
4041:
4039:
4036:
4034:
4031:
4029:
4026:
4024:
4021:
4019:
4016:
4014:
4011:
4009:
4006:
4004:
4001:
4000:
3998:
3996:(EC 2.7.11.1)
3995:
3991:
3987:
3982:
3977:
3973:
3968:
3964:
3960:
3953:
3948:
3946:
3941:
3939:
3934:
3933:
3930:
3923:
3919:
3918:TOR+complex+2
3916:
3915:
3903:
3899:
3894:
3889:
3885:
3881:
3878:(5): e13014.
3877:
3873:
3869:
3862:
3854:
3850:
3845:
3840:
3836:
3832:
3829:(3): 827–37.
3828:
3824:
3820:
3813:
3805:
3801:
3796:
3791:
3787:
3783:
3779:
3775:
3771:
3764:
3756:
3752:
3747:
3742:
3738:
3734:
3731:(6): 630–41.
3730:
3726:
3722:
3715:
3707:
3703:
3698:
3693:
3689:
3685:
3681:
3677:
3673:
3666:
3658:
3654:
3649:
3644:
3640:
3636:
3632:
3628:
3624:
3617:
3609:
3605:
3600:
3595:
3590:
3585:
3581:
3577:
3573:
3569:
3565:
3558:
3550:
3546:
3541:
3536:
3531:
3526:
3522:
3518:
3514:
3507:
3499:
3495:
3490:
3485:
3481:
3477:
3473:
3469:
3465:
3458:
3450:
3446:
3441:
3436:
3431:
3426:
3423:(1): 300–15.
3422:
3418:
3417:FASEB Journal
3414:
3407:
3399:
3395:
3390:
3385:
3380:
3375:
3371:
3367:
3363:
3356:
3348:
3344:
3339:
3334:
3331:(5): 725–38.
3330:
3326:
3322:
3315:
3307:
3303:
3298:
3293:
3289:
3285:
3281:
3277:
3273:
3266:
3258:
3254:
3249:
3244:
3239:
3234:
3230:
3226:
3222:
3218:
3214:
3207:
3199:
3195:
3190:
3185:
3180:
3175:
3171:
3167:
3164:(7): e69178.
3163:
3159:
3155:
3148:
3140:
3136:
3131:
3126:
3121:
3116:
3112:
3108:
3104:
3100:
3096:
3089:
3081:
3077:
3072:
3067:
3063:
3059:
3055:
3051:
3047:
3040:
3032:
3028:
3023:
3018:
3014:
3010:
3006:
2999:
2991:
2987:
2982:
2977:
2973:
2969:
2966:(7): 364–73.
2965:
2961:
2957:
2950:
2942:
2938:
2933:
2928:
2924:
2920:
2917:(5): 554–63.
2916:
2912:
2908:
2901:
2893:
2889:
2884:
2879:
2874:
2869:
2865:
2861:
2857:
2850:
2842:
2838:
2833:
2828:
2824:
2820:
2817:(5): 726–39.
2816:
2812:
2808:
2801:
2793:
2789:
2784:
2779:
2775:
2771:
2767:
2763:
2759:
2752:
2744:
2740:
2736:
2732:
2728:
2724:
2717:
2709:
2705:
2700:
2695:
2691:
2687:
2684:(7): 686–96.
2683:
2679:
2675:
2668:
2660:
2656:
2652:
2648:
2645:(2): 287–97.
2644:
2640:
2633:
2626:
2618:
2614:
2609:
2604:
2600:
2596:
2593:(2): 369–78.
2592:
2588:
2584:
2577:
2569:
2565:
2560:
2555:
2550:
2545:
2541:
2537:
2533:
2529:
2525:
2518:
2510:
2506:
2501:
2496:
2491:
2486:
2482:
2478:
2474:
2470:
2466:
2459:
2451:
2447:
2442:
2437:
2432:
2427:
2423:
2419:
2418:PLOS Genetics
2415:
2408:
2400:
2396:
2391:
2386:
2382:
2378:
2374:
2370:
2366:
2362:
2358:
2351:
2343:
2339:
2334:
2329:
2324:
2319:
2316:(6): 937–43.
2315:
2311:
2307:
2300:
2292:
2288:
2283:
2278:
2274:
2270:
2266:
2262:
2258:
2251:
2243:
2239:
2234:
2229:
2225:
2221:
2217:
2213:
2209:
2202:
2194:
2190:
2185:
2180:
2176:
2172:
2168:
2164:
2160:
2156:
2152:
2145:
2137:
2133:
2128:
2123:
2119:
2115:
2112:(2): 148–59.
2111:
2107:
2103:
2096:
2088:
2084:
2079:
2074:
2071:(2): 159–68.
2070:
2066:
2062:
2055:
2047:
2043:
2039:
2035:
2031:
2027:
2026:
2018:
2010:
2006:
2002:
1998:
1993:
1988:
1984:
1980:
1976:
1972:
1968:
1961:
1953:
1949:
1945:
1941:
1937:
1933:
1929:
1925:
1921:
1917:
1910:
1902:
1898:
1893:
1888:
1884:
1880:
1876:
1872:
1868:
1864:
1860:
1853:
1845:
1841:
1837:
1833:
1829:
1825:
1821:
1817:
1816:
1811:
1804:
1802:
1793:
1789:
1784:
1779:
1775:
1771:
1767:
1763:
1759:
1752:
1744:
1740:
1735:
1730:
1726:
1722:
1718:
1714:
1710:
1703:
1695:
1691:
1686:
1681:
1677:
1673:
1669:
1665:
1664:Cell Research
1661:
1654:
1646:
1642:
1637:
1632:
1628:
1624:
1621:(2): 270–84.
1620:
1616:
1612:
1605:
1597:
1593:
1588:
1583:
1579:
1575:
1571:
1567:
1560:
1558:
1549:
1545:
1540:
1535:
1531:
1527:
1524:(8): e13431.
1523:
1519:
1515:
1508:
1506:
1504:
1495:
1491:
1486:
1481:
1477:
1473:
1470:(2): 124–31.
1469:
1465:
1461:
1454:
1446:
1442:
1438:
1434:
1430:
1426:
1423:(4): 757–64.
1422:
1418:
1411:
1403:
1399:
1395:
1391:
1387:
1383:
1379:
1375:
1367:
1359:
1355:
1351:
1347:
1343:
1339:
1335:
1331:
1327:
1323:
1316:
1314:
1305:
1301:
1297:
1293:
1288:
1283:
1279:
1275:
1271:
1267:
1263:
1256:
1248:
1244:
1239:
1234:
1229:
1224:
1220:
1216:
1212:
1205:
1203:
1194:
1190:
1185:
1180:
1176:
1172:
1168:
1164:
1160:
1153:
1145:
1141:
1136:
1131:
1127:
1123:
1119:
1115:
1111:
1104:
1096:
1092:
1087:
1082:
1078:
1074:
1070:
1066:
1065:Cell Research
1062:
1055:
1047:
1043:
1038:
1033:
1029:
1025:
1022:(2): 274–93.
1021:
1017:
1013:
1006:
998:
994:
989:
984:
980:
976:
972:
968:
964:
957:
955:
953:
948:
941:
939:
935:
931:
926:
922:
918:
914:
910:
906:
901:
899:
894:
892:
888:
887:lung fibrosis
883:
881:
877:
873:
869:
865:
860:
858:
854:
850:
846:
842:
831:
829:
825:
821:
817:
807:
805:
801:
797:
792:
789:
782:
772:
770:
766:
762:
752:
750:
747:
743:
738:
736:
732:
729:, such as of
728:
727:endomembranes
723:
721:
717:
713:
709:
705:
701:
697:
693:
689:
685:
681:
677:
673:
669:
664:
662:
658:
654:
650:
646:
642:
638:
637:stress fibers
635:
631:
627:
623:
613:
611:
607:
603:
599:
595:
591:
587:
583:
579:
575:
571:
567:
564:
560:
557:-insensitive
556:
552:
548:
536:
533:
529:
526:
523:
519:
514:
510:
507:
506:
502:
499:
497:
493:
488:
485:
482:
480:
476:
473:
470:
468:
464:
461:
458:
456:
452:
449:
446:
444:
440:
437:
434:
432:
428:
425:
422:
418:
413:
410:
406:
395:
392:
388:
385:
382:
378:
373:
369:
366:
365:
361:
358:
356:
352:
347:
344:
341:
339:
335:
332:
329:
327:
323:
320:
317:
315:
311:
308:
305:
303:
299:
296:
293:
291:
287:
284:
281:
277:
272:
269:
265:
258:
257:
253:
250:
248:
244:
239:
236:
233:
231:
227:
224:
221:
219:
215:
212:
209:
207:
203:
200:
197:
193:
188:
185:
181:
170:
167:
163:
160:
157:
153:
148:
144:
141:
140:
136:
133:
131:
127:
124:
121:
119:
115:
110:
107:
104:
102:
98:
95:
92:
90:
86:
83:
80:
78:
74:
71:
68:
66:
62:
59:
56:
54:
50:
46:
42:
39:
36:
32:
27:
24:
20:
6058:Translocases
6055:
6042:
6029:
6016:
6003:
5993:Transferases
5990:
5977:
5834:Binding site
5265:P70S6 kinase
3875:
3871:
3861:
3826:
3822:
3812:
3777:
3773:
3763:
3728:
3724:
3714:
3682:(1): 61–70.
3679:
3675:
3665:
3630:
3626:
3616:
3571:
3567:
3557:
3520:
3516:
3506:
3474:(5): 911–7.
3471:
3467:
3457:
3420:
3416:
3406:
3369:
3365:
3355:
3328:
3324:
3314:
3279:
3275:
3265:
3220:
3216:
3206:
3161:
3157:
3147:
3102:
3098:
3088:
3062:10.2741/4886
3053:
3049:
3039:
3012:
3008:
2998:
2963:
2959:
2949:
2914:
2910:
2900:
2863:
2859:
2849:
2814:
2810:
2800:
2765:
2762:FEBS Letters
2761:
2751:
2726:
2722:
2716:
2681:
2677:
2667:
2642:
2638:
2625:
2590:
2586:
2576:
2531:
2527:
2517:
2472:
2468:
2458:
2421:
2417:
2407:
2364:
2360:
2350:
2313:
2310:Cell Reports
2309:
2299:
2264:
2260:
2250:
2215:
2211:
2201:
2158:
2154:
2144:
2109:
2105:
2095:
2068:
2064:
2054:
2029:
2023:
2017:
1974:
1970:
1960:
1923:
1919:
1909:
1866:
1862:
1852:
1819:
1813:
1810:Monteggia LM
1765:
1761:
1751:
1719:(1): 21–35.
1716:
1712:
1702:
1670:(1): 46–65.
1667:
1663:
1653:
1618:
1614:
1604:
1569:
1521:
1517:
1467:
1463:
1453:
1420:
1416:
1410:
1377:
1373:
1366:
1325:
1321:
1269:
1265:
1255:
1218:
1214:
1166:
1162:
1152:
1120:(6): 320–8.
1117:
1113:
1103:
1068:
1064:
1054:
1019:
1015:
1005:
970:
966:
937:
929:
924:
916:
912:
904:
902:
895:
891:sapanisertib
884:
880:melanogaster
879:
875:
861:
857:sphingolipid
837:
813:
793:
778:
764:
758:
739:
731:mitochondria
724:
665:
630:cytoskeleton
619:
578:cytoskeletal
550:
546:
545:
503:
362:
254:
137:
44:Alt. symbols
5829:Active site
5716:(EC 2.7.12)
5103:Polo kinase
5043:Polo kinase
3009:Cancer Cell
2866:: 7838647.
2106:Cancer Cell
859:synthesis.
849:lipogenesis
826:, PKC and
525:Swiss-model
415:Identifiers
384:Swiss-model
274:Identifiers
190:Identifiers
159:Swiss-model
29:Identifiers
6101:Categories
6032:Isomerases
6006:Hydrolases
5873:Regulation
4394:IκB kinase
3969:2.7.11-12)
3872:Aging Cell
3523:: e56177.
3468:Aging Cell
1518:Aging Cell
944:References
561:formed by
521:Structures
516:Search for
490:Other data
380:Structures
375:Search for
349:Other data
241:Other data
155:Structures
150:Search for
112:Other data
6132:EC 2.7.11
5911:EC number
4520:PKC alpha
2729:: 39–48.
1940:1476-4679
1883:1534-5807
1169:: 79–90.
864:rapamycin
804:G protein
781:PH domain
704:autophagy
692:threonine
555:rapamycin
431:NCBI gene
331:NM_022372
290:NCBI gene
235:NM_152756
206:NCBI gene
118:EC number
94:NM_004958
53:NCBI gene
5935:Kinetics
5859:Cofactor
5822:Activity
4876:KIAA0999
4771:MAPKAPK5
4766:MAPKAPK3
4761:MAPKAPK2
3902:31373126
3853:21266327
3823:Diabetes
3804:27304501
3755:25161886
3706:17967879
3657:20332342
3627:Diabetes
3608:19497867
3549:32720643
3498:25059582
3449:24072782
3398:22773877
3347:22521878
3306:29866702
3257:25162417
3217:PLOS ONE
3198:23935948
3158:PLOS ONE
3139:29329306
3099:PLOS ONE
3080:32472766
3031:29232555
2990:24856037
2941:24631838
2892:30510625
2841:24140020
2792:28600802
2743:28189457
2708:22609986
2659:21806543
2617:25196701
2568:22307628
2509:25422441
2450:32392211
2399:21659604
2342:26235620
2291:26293922
2242:20860370
2193:22461615
2136:19185849
2087:16603397
2046:26269525
2001:16919458
1952:38951708
1901:37220748
1892:10524337
1836:24165680
1792:28143890
1743:21157483
1694:26584640
1645:26118642
1596:24606695
1570:Virology
1548:34250734
1494:20034776
1445:25454463
1437:16550606
1358:45837814
1350:15718470
1296:15268862
1247:23852728
1193:25242279
1144:21531565
1095:29567957
1046:22500797
997:28283069
720:tyrosine
700:Curcumin
641:paxillin
616:Function
535:InterPro
394:InterPro
169:InterPro
123:2.7.11.1
6091:Biology
6045:Ligases
5815:Enzymes
5535:MAP3K14
5513:MAP3K11
5508:MAP3K10
5498:MAP3K13
5493:MAP3K12
5295:RPS6KC1
5290:RPS6KA1
5285:RPS6KA3
5280:RPS6KA2
5275:RPS6KB2
5260:RPS6KA4
5255:RPS6KA5
4906:Kalirin
4871:SNF1LK2
4110:EIF2AK4
4105:EIF2AK3
3959:Kinases
3924:(MeSH)}
3893:6718533
3844:3046843
3795:4910876
3746:4142396
3697:2223287
3648:2874700
3599:2700987
3576:Bibcode
3540:7386906
3489:4172536
3440:3868844
3389:3436168
3297:6039264
3248:4146613
3225:Bibcode
3189:3728301
3166:Bibcode
3130:5766080
3107:Bibcode
3071:7265993
2981:4077930
2932:4012430
2883:6232796
2832:3840163
2783:6322652
2699:3389271
2608:4322759
2559:3277174
2536:Bibcode
2500:4267365
2477:Bibcode
2441:7252638
2390:3177140
2369:Bibcode
2361:Science
2282:4631654
2233:3893826
2184:3324089
2163:Bibcode
2155:Science
2127:2701381
2009:8239162
1979:Bibcode
1844:7820105
1783:5294791
1734:3390257
1685:4816127
1636:4506737
1587:4005847
1539:8373318
1485:2854249
1402:9445477
1382:Bibcode
1374:Science
1330:Bibcode
1322:Science
1304:4658268
1274:Bibcode
1238:3732980
1184:4253687
1135:3112285
1086:5951902
1037:3331679
988:5394987
928:mTORC2/
769:Torin-1
765:in vivo
742:neurons
684:Akt/PKB
676:Akt/PKB
634:F-actin
606:Protor1
531:Domains
479:UniProt
424:MAPKAP1
409:MAPKAP1
390:Domains
360:Chr. 16
338:UniProt
165:Domains
101:UniProt
6077:Portal
6019:Lyases
5765:MAP2K7
5760:MAP2K6
5755:MAP2K5
5750:MAP2K4
5745:MAP2K3
5740:MAP2K2
5735:MAP2K1
5686:ACVRL1
5681:ACVR2B
5676:ACVR2A
5671:ACVR1C
5666:ACVR1B
5649:BMPR1B
5644:BMPR1A
5518:MAP3K7
5503:MAP3K9
5454:MAP3K8
5449:MAP3K7
5444:MAP3K6
5439:MAP3K5
5434:MAP3K4
5429:MAP3K3
5424:MAP3K2
5419:MAP3K1
5393:MAPK14
5388:MAPK13
5383:MAPK11
5371:MAPK10
5349:MAPK15
5344:MAPK12
5236:CDC2L1
5211:CDC2L5
4886:SNF1LK
4711:CAMK2G
4706:CAMK2D
4701:CAMK2B
4696:CAMK2A
4686:CAMK1G
4681:CAMK1D
4676:CAMK1B
4671:CAMK1A
4525:PRKCB1
4462:PRKACA
4457:PRKACB
4452:PRKACG
4428:IKBKAP
4254:BCKDHB
4249:BCKDHA
4223:PRKAG3
4218:PRKAG2
4213:PRKAG1
4203:PRKAB2
4198:PRKAB1
4188:PRKAA2
4183:PRKAA1
4028:STK38L
3900:
3890:
3851:
3841:
3802:
3792:
3753:
3743:
3704:
3694:
3655:
3645:
3606:
3596:
3547:
3537:
3496:
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