553:"Neurofilament light chain in blood and CSF as marker of disease progression in mouse models and in neurodegenerative diseases". Bacioglu M, Maia LF, Preische O, Schelle J, Apel A, Kaeser SA, Schweighauser M, Eninger T, Lambert M, Pilotto A, Shimshek D, Neumann U, Kahle PJ, Staufenbiel M, Neumann M, Maetzler W, Kuhle J, Jucker M (2016).
433:"Exogenous induction of Aβ-amyloidogenesis is governed by intrinsic properties of agent and host". Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret J, Paganetti P, Walsh DM, Mathews P, Ghiso J, Staufenbiel M, Walker L, Jucker M (2006).
418:"Aß is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis". Herzig MC, Winkler DT, Burgermeister P, Pfeifer M, Kohler E, Schmidt SD, Danner S, Abramowski D, Stürchler-Pierrat C, Bürki K, van Duinen SG, Maat-Schieman MLC, Staufenbiel M, Mathews PM, Jucker M (2004).
285:(Switzerland). In 2003 he became Full Professor of Cell Biology of Neurological Diseases at the University of Tübingen. In 2009 he was named a group leader at the DZNE in Tübingen, and in 2012 he became the founding coordinator of the Dominantly Inherited Alzheimer's Disease Network (DIAN) in Germany.
568:"Microglia turnover with aging and in an Alzheimer´s model via long-term in vivo single-cell imaging". Füger P, Hefendehl JK, Veeraraghavalu K, Schlosser C, Wendeln A-C, Obermüller U, Wegenast-Braun BM, Neher JJ, Martus P, Kohsaka S, Thunemann M, Feil R, Sisodia SS, Skodras A, Jucker M (2017).
598:"Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer´s disease". Preische O, Schultz S, Apel A, Kuhle J, Kaeser SA, Barro C, Gräber S, Kuder-Buletta E, LaFougere C, Laske C, Vöglein J, Levin J, Masters CL, Martins R, Schofield PR,
448:"Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia". Grathwohl SA, Kälin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL, Jucker M (2009).
602:, Graff-Radford NR, Salloway S, Ghetti B, Ringman JM, Noble JM, Chhatwal J, Goate AM, Benzinger TLS, Morris JC, Bateman RJ, Wang G, Fagan AM, McDade EM, Gordon BA, Jucker M, Dominantly Inherited Alzheimer Network (2019).
463:"Peripherally applied Aß-containing inoculates induce cerebral β-amyloidosis". Eisele YS, Obermueller U, Heilbronner G, Baumann F, Kaeser SA, Wolburg H, Walker LC, Staufenbiel M, Heikenwalder M, Jucker M (2010).
508:"Changes in amyloid-β and Tau in the cerebrospinal fluid of transgenic mice overexpressing amyloid precursor protein". Maia LF, Kaeser SA, Reichwald J, Hruscha M, Martus P, Staufenbiel M, Jucker M (2013).
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538:"Persistence of Aß seeds in APP-null mouse brain". Ye L, Fritschi SK, Schelle J, Obermüller U, Degenhardt K, Kaeser SA, Eisele YS, Walker LC, Baumann F, Staufenbiel M, Jucker M (2015).
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403:"Cerebral hemorrhage following anti-Aß-immunotherapy". Pfeifer M, Boncristiano S, Bondolfi L, Stalder A, Deller T, Staufenbiel M, Mathews P, Jucker M (2002).
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350:(CSF) biomarkers in mouse models closely resemble the changes in humans with Alzheimer's disease, and he and his colleagues showed that a protein in
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314:, Jucker was the first to show in experimental mice that the accumulation of abnormally folded proteins in Alzheimer's disease occurs by a
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389:(2014), and the International Prize for Translational Neuroscience of the Gertrud Reemtsma Foundation (Max-Planck-Gesellschaft) (2020).
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478:"The benefits and limitations of animal models for translational research in neurodegenerative diseases". Jucker M (2010)
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International Prize for
Translational Neuroscience of the Gertrud Reemtsma Foundation (Max-Planck-Gesellschaft) (2020)
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583:"Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases". Jucker M, Walker LC (2018).
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Jucker has received the
Research Prize of the Swiss Alzheimer Association (2001), the Zenith Fellows Award of the
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523:"Self-propagation of pathogenic protein aggregates in neurodegenerative diseases". Jucker M, Walker LC (2013).
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318:-like mechanism. The prion concept has since been expanded to include several other proteins, including
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Medizin: „Habe auch den Defekt“ (Article on the
Dominantly Inherited Alzheimer Network in Germany)
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https://scholar.google.com/scholar?hl=en&as_sdt=0%2C11&q=mathias+jucker&oq=mathias
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and cerebrospinal fluid that can be used to determine the progression of
Alzheimer's Disease.
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493:"The amyloid state of proteins in human diseases". Eisenberg D, Jucker M (2012).
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Die Saat des
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Metlife
Foundation Award for Medical Research in Alzheimer's Disease
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Jucker received his doctoral degree (1988) in
Natural Sciences from
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Metlife
Foundation Award for Medical Research in Alzheimer's Disease
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242:: Deutsches Zentrum für Neurodegenerative Erkrankungen, (DZNE)) in
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381:(2010), the Hamburg Science Award for dementia research from the
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Jucker also has contributed to the development and validation of
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858:"The Dominantly Inherited Alzheimer's Disease Network (DIAN)"
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Jucker's research has focused on understanding how certain
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cause disease by adopting abnormal 3-dimensional shapes (
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Research Prize of the Swiss
Alzheimer Association (2001)
709:"American Neurological Association Soriano Lectureship"
726:"The 2013 Hamburg Science Award for dementia research"
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5, 194re2 (2013). doi: 10.1126/scitranslmed.3006446;
816:"International Prize for Translational Neuroscience"
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675:"Research Prize of the Swiss Alzheimer Association"
958:The red-hot debate about transmissible Alzheimer's
644:Proteopathic Seeds and Neurodegenerative Diseases
497:148: 1188-1203. doi: 10.1016/j.cell.2012.02.022;
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294:Prion-like properties of disease-causing proteins
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587:21: 1341-1349. doi: 10.1038/s41593-018-0238-6;
82:(Swiss Federal Institute of Technology Zürich;
557:91: 56-66. doi: 10.1016/j.neuron.2016.05.018;
437:313: 1781-1784. doi: 10.1126/science.1131864;
86:: Eidgenössische Technische Hochschule Zürich)
606:25: 277-283. doi: 10.1038/s41591-018-0304-3;
383:Academy of Sciences and Humanities in Hamburg
110:Academy of Sciences and Humanities in Hamburg
1008:Academic staff of the University of Tübingen
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467:330: 980-982. doi: 10.1126/science.1194516;
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161:Swiss Federal Institute of Technology Zürich
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346:disorders. He found that changes in
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618:Complete List of Published Work:
379:American Neurological Association
334:Biomarkers of Alzheimer's disease
793:"2014 MetLife Foundation Awards"
422:7: 954-60. doi: 10.1038/nn1302;
361:can serve as a biomarker in the
1003:Alzheimer's disease researchers
631:Alzheimer: 100 Years and Beyond
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108:Hamburg Science Award from the
18:Mathias Jucker (neuroscientist)
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510:Science Translational Medicine
398:Selected research publications
27:Swiss neuroscientist (b. 1961)
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692:"The Zenith Fellows Awards"
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271:National Institute on Aging
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104:Zenith Fellows Award (2006)
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830:"DZNE Research Groups"
232:University of Tübingen
171:University of Tübingen
218:(born 7 July 1961 in
261:Education and career
998:Medical researchers
903:10.1038/nature12481
778:on 13 October 2018.
585:Nature Neuroscience
570:Nature Neuroscience
540:Nature Neuroscience
450:Nature Neuroscience
420:Nature Neuroscience
348:cerebrospinal fluid
283:University of Basel
255:Alzheimer's disease
166:University of Basel
281:, and then at the
993:ETH Zurich alumni
652:978-3-642-35491-5
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344:neurodegenerative
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1013:1961 births
359:light chain
324:α-synuclein
312:Lary Walker
224:Switzerland
68:Nationality
61:Switzerland
50:7 July 1961
982:Categories
658:References
340:biomarkers
267:ETH Zürich
80:ETH Zürich
46:1961-07-07
600:Rossor MN
354:known as
306:) in the
275:Baltimore
273:(NIA) in
173:, Germany
143:Neurology
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300:proteins
289:Research
244:Tübingen
912:3963807
798:YouTube
748:YouTube
465:Science
435:Science
405:Science
352:neurons
207:/jucker
182:Website
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240:German
220:Zürich
131:Fields
117:(2014)
112:(2013)
99:Awards
84:German
57:Zürich
776:(PDF)
769:(PDF)
625:Books
363:blood
316:prion
251:aging
248:brain
203:.dzne
158:, USA
71:Swiss
917:PMID
648:ISBN
635:ISBN
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322:and
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