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principle, i.e., a substance that is released in the body by a metabolic modification from precursors, which are pharmacologically active. According to B.J. Hagwood, Rocha e Silva's biographer, "The discovery of bradykinin has led to a new understanding of many physiological and pathological
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Rocha e Silva had many interests besides scientific research and pharmacology. He was an accomplished amateur painter and a writer of fiction and non-fiction. He was interested in the
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178:(AAAS) counterparts. He was to become three times president of SBPC and its lifetime honorary president. Rocha e Silva was also a founding member of the
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Rocha e Silva was one of the greatest scientific and academic leaders of recent history in Brazil. In 1948, with a group of fellow scientists, such as
190:(the highest scientific decoration at the time in Brazil) as well as the National Award of Science and Technology from the National Research Council (
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99:), lecturing in high schools while he was a student in order to support himself. Shortly after graduation he moved in 1937 to
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The practical importance of the discovery of bradykinin became apparent when one of his collaborators at Ribeirão Preto,
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related to the toxicology of snake bites, started by Rocha e Silva as early as 1939. Bradykinin was to be proved a new
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263:(BPF) in the bothropic venom which increases powerfully both the duration and magnitude of its effects on
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170:(SBPC – Brazilian Society of the Advancement of Science), similar in scope and philosophy to its
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in animal preparations. Bradykinin was detected in the plasma of animals after the addition of
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107:, a state research institution. From 1940 to 1941, Rocha e Silva won a fellowship from the
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Mauricio Rocha e Silva MD: snake venom, bradykinin and the rise of autopharmacology
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scientists developed the first of a new generation of highly-effective
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phenomena including circulatory shock induced by venoms and toxins."
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Brazilian
Society of Pharmacology and Experimental Therapeutics
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control and many other phenomena related to the contraction of
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to go to London, England, where he studied and worked with
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300:Brazilian Society for the Advancement of Science
168:Sociedade Brasileira para o Progresso da Ciência
366:Members of the Brazilian Academy of Sciences
376:Federal University of Rio de Janeiro alumni
109:John Simon Guggenheim Memorial Foundation
335:Remarkable Persons in Brazilian Science
194:). He was also a vice-president of the
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271:. On the basis of this finding,
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371:University of São Paulo alumni
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331:Maurício Rocha e Silva
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188:Moinho Santista Award
105:Biological Institute
93:University of Brazil
36:– 19 December 1983,
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249:autopharmacological
230:Butantan Institute
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225:Bothrops jararaca
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356:1983 deaths
351:1910 births
242:proteolytic
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345:Categories
283:, such as
216:bradykinin
61:physiology
54:endogenous
50:bradykinin
285:captopril
234:São Paulo
156:José Reis
149:São Paulo
121:histamine
101:São Paulo
69:pathology
302:(SBPC).
176:American
317:Toxicon
245:enzymes
172:British
139:of the
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95:(later
273:Squibb
125:venoms
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