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field of medicine, so that patients could legally be diagnosed by a computer rather than by a human. AbrĂ moff credits this achievement as well the subsequent national reimbursement, coding, and quality measurement, as well as widespread support by all healthcare stakeholders, on the ethical framework for AI in healthcare. This work continues in collaboration with both FDA and other US and international regulatory authorities as well as CMS and other payor organizations including publication of an ethically founded AI reimbursement framework.
25:
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In
January 2018, the results of a clinical trial for the first autonomous AI in primary care were submitted to FDA, exceeding its pre-specified superiority endpoints for diagnostic accuracy. FDA assigned the LumineticsCore (then IDx-DR) system breakthrough device status for expedited review. In April
153:
AbrĂ moff has been a proponent of the theory that diabetes complications in the eye and brain are neural, not vascular, in origin, based on his team's earlier finding that microvascular biomarkers of diabetic damage in the retina only occur after neurodegenerative changes. Additionally, AbrĂ moff has
181:
clearance was granted to the autonomous AI product, IDx-DR (now
LumineticsCore) on April 18, 2018, created by the company AbrĂ moff founded in 2010, Digital Diagnostics (formerly IDx) of Coralville Iowa. That marked the first time that an autonomous diagnostic platform was cleared by the FDA in any
185:
AbrĂ moff is a founding member of FDA's
Collaborative Community on Ophthalmic Imaging (CCOI), which was formed in 2019. AbrĂ moff also chairs the Foundational Principles of Ophthalmic Imaging and Algorithmic Interpretation (FPOAI) Workgroup. In 2019, AbrĂ moff founded the AI Healthcare Coalition and
173:
AbrĂ moff began working with regulators in 2010 to develop a process by which to introduce autonomous AI in healthcare. During that time, with his coworkers he developed "metrics for ethics" as a concept, as well as an ethical framework for healthcare AI, which led to an ongoing series of papers
441:
Sohn, Elliott H.; van Dijk, Hille W.; Jiao, Chunhua; Kok, Pauline H. B.; Jeong, Woojin; Demirkaya, Nazli; Garmager, Allison; Wit, Ferdinand; Kucukevcilioglu, Murat; van
Velthoven, Mirjam E. J.; DeVries, J. Hans; Mullins, Robert F.; Kuehn, Markus H.; Schlingemann, Reinier Otto; Sonka, Milan
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AbrĂ moff, Michael D.; Cunningham, Brad; Patel, Bakul; Eydelman, Malvina B.; Leng, Theodore; Sakamoto, Taiji; Blodi, Barbara; Grenon, S. Marlene; Wolf, Risa M.; Manrai, Arjun K.; Ko, Justin M.; Chiang, Michael F.; Char, Danton; Abramoff, Michael; Blumenkranz, Mark (February 2022).
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editorial in 2010, referring to the work he had done to create the first autonomous AI diagnostic system. Roughly a decade later, the medical community's stance on healthcare AI had evolved, as evidenced by a 2019 American
Medical Association (AMA) article on AbrĂ moff, titled
509:
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In
October 2017, in a Congressional Briefing sponsored by the Science Coalition, AbrĂ moff joined a panel of companies that spun out of U.S. research universities. The panelists highlighted to lawmakers the value of putting federal funds toward academic research.
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AbrĂ moff was born in
Rotterdam, the Netherlands, and received his MD and MS (information theory) from the University of Amsterdam. AbrĂ moff did his graduate research, leading to a Ph.D. in machine learning, at the
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He is inventor on over 60 US and international patents and patent applications primarily related to machine learning, artificial intelligence (AI) and imaging AbrĂ moff was one of the early developers of
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510:"JDRF and The Mary Tyler Moore & S. Robert Levine, MD Charitable Foundation Launch Research Moonshot to Restore Vision in People with Diabetes-Related Eye Disease"
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AbrĂ moff, Michael D.; Roehrenbeck, Cybil; Trujillo, Sylvia; Goldstein, Juli; Graves, Anitra S.; Repka, Michael X.; Silva III, Ezequiel "Zeke" (2022-06-09).
158:) from the outset. AbrĂ moff started working on autonomous AI for diagnosis of retinal diseases during his residency in 1997, which led to the publishing of
150:, a Java-based image processing program. He was the initiator behind the Iowa Reference Algorithms, a series of reference algorithms for OCT segmentation.
361:"Iowa Reference Algorithms: Human and Murine OCT Retinal Layer Analysis and Display | Iowa Institute for Biomedical Imaging - The University of Iowa"
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Abramoff MD, Staal J, Suttorp MSA, Polak BC, Viergever MA. Low level screening of exudates and hemorrhages in background diabetic retinopathy.
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Professor of
Ophthalmology and Visual Sciences, Professor of Electrical and Computer Engineering (ECE), Professor of Biomedical Engineering (BME)
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Oprichting i-Optics
Nederland B.V. Oprichting Besloten Vennootschap. Westvest Netwerk Notarissen, Delft (www.westvest-notarissen.nl)
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In 2010, AbrĂ moff founded IDx
Technologies, Inc., which has since rebranded as Digital Diagnostics of which he is Executive Chairman.
116:, vitreoretinal surgeon, computer engineer, and entrepreneur. He is the Watzke Professor of Ophthalmology and Visual Sciences at the
959:"Conversations in Retina: A Conversation With Michael Abramoff, MD, PhD – Automating the screening process for diabetic retinopathy"
198:, a teleretinal diabetic retinopathy screening company in Amsterdam, the Netherlands, and i-Optics, an ophthalmic device company.
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for creating a simple and more efficient process of autonomous AI for the retina that is in the best interest of the patient.
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444:"Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus"
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In 2018, AbrĂ moff testified for the Federal Trade Commission on AI Predictive Analytics Through Real World Applications.
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683:"Lessons Learned About Autonomous AI: Finding a Safe, Efficacious, and Ethical Path Through the Development Process"
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1045:"Three University of Iowa faculty members named IEEE Fellows | College of Engineering - The University of Iowa"
743:"FDA permits marketing of artificial intelligence-based device to detect certain diabetes-related eye problems"
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in 2000 and many other papers . This research led to him receiving the nickname "The Retinator" in an
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Proceedings of the 1st International Workshop on Computer Assisted Fundus Image Analysis
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published through the Foundational Principles of Algorithmic Interpretation workgroup.
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serves as Executive Secretary, focusing on the policy implications of healthcare AI.
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Low Level Screening of Exudates and Hemorrhages in Background Diabetic Retinopathy
1007:"FTC hearing: Not all AI is created equal, so safety and validation are critical"
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626:"Foundational Considerations for Artificial Intelligence Using Ophthalmic Images"
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2018 FDA granted De Novo authorization to market this product in the US.
983:"HIStalk Interviews Michael Abramoff, MD, PhD, President, IDx – HIStalk"
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AbrĂ moff, Michael D.; Tobey, Danny; Char, Danton S. (March 12, 2020).
771:"A reimbursement framework for artificial intelligence in healthcare"
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2019 Fellow, Institute of Electrical and Electronics Engineers (IEEE)
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Hoogendiuk, Oeke (May 24, 1996). "Zo groot, mooi en toegankelijk ".
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After working with the FDA for over 8 years under this framework,
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347:"Patent Public Search Basic | USPTO. (n.d.). Ppubs.uspto.gov"
572:"This ophthalmologist is doing health care AI the right way"
934:"The Association for Research in Vision and Ophthalmology-"
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This Ophthalmologist is Doing Health Care AI the Right Way.
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UI physician briefs Congress on how research spurs economy
597:"Collaborative Community on Ophthalmic Imaging Foundation"
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Lynch, Stephanie K.; AbrĂ moff, Michael D. (2017-10-01).
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at the Roy J. and Lucille A. Carver College of Medicine
386:"Diabetic retinopathy is a neurodegenerative disorder"
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909:"A Breakthrough in Diagnosing Diabetic Retinopathy"
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154:been part of the Moonshot team (formally known as
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886:Ophthalmology, University of Iowa (2017-10-30),
212:AbrĂ moff has been called a "Renaissance Man" by
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118:Roy J. and Lucille A. Carver College of Medicine
448:Proceedings of the National Academy of Sciences
315:"Objective measurement of motion in the orbit"
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536:. Copenhagen, Denmark, May 29–30, 2000: 15.
156:Restoring Vision: A JDRF Moonshot Initiative
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112:(born 1963) is an American neuroscientist,
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141:Scientific and medical career
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576:American Medical Association
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1128:Senior members of the IEEE
1123:University of Iowa faculty
1103:Dutch electrical engineers
787:10.1038/s41746-022-00621-w
293:Carver College of Medicine
267:Carver College of Medicine
1118:Utrecht University alumni
1098:Dutch computer scientists
1088:American ophthalmologists
700:10.1016/j.ajo.2020.02.022
547:"Revenge of the machines"
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128:Early life and education
858:AI Healthcare Coalition
469:10.1073/pnas.1522014113
1093:Dutch ophthalmologists
110:Michael David AbrĂ moff
32:This article contains
1049:engineering.uiowa.edu
135:University of Utrecht
46:neutral point of view
963:retinalphysician.com
775:npj Digital Medicine
319:dspace.library.uu.nl
551:Ophthalmology Times
460:2016PNAS..113E2655S
164:Ophthalmology Times
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