125:, or in order to realize the ideas of virtual screening and drug design are also called building blocks. To be practically useful for the modular drug or drug candidate assembly, the building blocks should be either mono-functionalised or possessing selectively chemically addressable functional groups, for example, orthogonally protected. Selection criteria applied to organic functionalized molecules to be included in the building block collections for medicinal chemistry are usually based on empirical rules aimed at
145:
collections prepared for fast and reliable construction of small-molecule sets of compounds (libraries) for biological screening became one of the major strategies for pharmaceutical industry involved in drug discovery; modular, usually one-step synthesis of compounds for biological screening from building blocks turned out to be in most cases faster and more reliable than multistep, even convergent syntheses of target compounds.
31:
180:
144:
The building block approach to drug discovery changed the landscape of chemical industry which supports medicinal chemistry. Major chemical suppliers for medicinal chemistry like
Maybridge, Chembridge, Enamine adjusted their business correspondingly. By the end of the 1990th the use of building block
333:
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V.S. Yarmolchuk; O.V. Shishkin; V.S. Starova; O.A. Zaporozhets; O. Kravchuk; S. Zozulya; I.V. Komarov; P.K. Mykhailiuk (2013). "Synthesis and
Characterization of β-Trifluoromethyl-Substituted Pyrrolidines".
782:
A.V. Tymtsunik; V.A. Bilenko; S.O. Kokhan; O.O. Grygorenko; D.M. Volochnyuk; I.V. Komarov (2012). "1-Alkyl-5-((di)alkylamino) Tetrazoles: Building Blocks for
Peptide Surrogates".
533:
R.Breinbauer; I. R. Vetter; H.Waldmann (2002). "From
Protein Domains to Drug Candidates—Natural Products as Guiding Principles in the Design and Synthesis of Compound Libraries".
168:
properties, therefore, the fluorine-substituted building blocks in drug design increase the probability of finding drug leads. Other examples include natural and unnatural
298:
O. K. Farha; C. D. Malliakas; M.G. Kanatzidis; J.T. Hupp (2010). "Control over
Catenation in Metal−Organic Frameworks via Rational Design of the Organic Building Block".
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121:
Organic functionalized molecules (reagents), carefully selected for the use in modular synthesis of novel drug candidates, in particular, by
109:. Of special interest for this purpose are the building blocks common to known biologically active compounds, in particular, known drugs, or
1069:
O.O. Grygorenko; D.S. Radchenko; D.M. Volochnyuk; A.A. Tolmachev; I.V. Komarov (2011). "Bicyclic
Conformationally Restricted Diamines".
611:
A. Linusson; J. Gottfries; F. Lindgren; S. Wold (2000). "Statistical
Molecular Design of Building Blocks for Combinatorial Chemistry".
17:
546:
683:"Conformationally restricted monoprotected diamines as scaffolds for design of biologically active compounds and peptidomimetics"
1032:"Conformationally rigid cyclic α-amino acids in the design of peptidomimetics, peptide models and biologically active compounds"
259:"Dendrimers and other dendritic macromolecules: From building blocks to functional assemblies in nanoscience and nanotechnology"
113:. There are algorithms for de novo design of molecular architectures by assembly of drug-derived virtual building blocks.
45:
which is used to describe a virtual molecular fragment or a real chemical compound the molecules of which possess reactive
61:
complexes. Using building blocks ensures strict control of what a final compound or a (supra)molecular construct will be.
160:-containing building blocks. Introduction of the fluorine into a molecule has been shown to be beneficial for its
681:
A.N. Shivanyuk; D.M. Volochnyuk; I.V. Komarov; K.G. Nazarenko; D.S. Radchenko; A. Kostyuk; A.A. Tomachev (2007).
817:"A MARKET GROWS, BLOCK BY BLOCK. Pharmaceutical building-block business attracts firms from ACROSS THE GLOBE".
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replacements of the molecular fragments in drug candidates could be made using analogous building blocks.
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Construction of complex molecular architectures is easily possible using simple building blocks
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Typical examples of building block collections for medicinal chemistry are libraries of
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105:, addressing the desire to have controllable molecular morphologies that interact with
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libraries, collections of conformationally constrained bifunctionalized compounds and
49:. Building blocks are used for bottom-up modular assembly of molecular architectures:
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73:, the term defines either imaginable, virtual molecular fragments or chemical
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M Schlosser (2006). "CF3-Bearing Aromatic and Heterocyclic Building Blocks".
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J. Wang; T. Hou (2010). "Drug and Drug Candidate Building Block Analysis".
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and two building blocks BB1 and BB2 from which it could be synthesized
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I. Muegge (2003). "Selection criteria for drug-like compounds".
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845:"Maybridge building blocks and reactive intermediates"
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Fluorine in Medicinal Chemistry and Chemical Biology
1106:"Organic chemistry: Molecular diversity by design"
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208:Organic Building Blocks of the Chemical Industry
85:might be constructed or synthetically prepared.
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129:properties of the final drug candidates.
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946:Angewandte Chemie International Edition
535:Angewandte Chemie International Edition
65:Building blocks for medicinal chemistry
14:
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888:"Good Suppliers – And The Other Guys"
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873:"Building Blocks for Drug Discovery"
117:Chemical reagents as building blocks
93:Virtual building blocks are used in
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211:. New York: John Wiley & Sons.
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148:There are online web-resources.
57:, organic molecular constructs,
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660:10.1016/S1359-6446(01)02091-8
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859:"Building Blocks: Key Facts"
761:10.1016/j.drudis.2014.09.023
687:Chimica Oggi/Chemistry Today
263:J. Polym. Sci. A Polym. Chem
176:building block collections.
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383:10.1016/j.addr.2003.10.047
831:10.1021/cen-v089n018.p016
406:J. Comput.-Aided Mol. Des
18:Molecular building blocks
1036:Russian Chemical Reviews
1011:. Blackwell Publishing.
512:10.2174/0929867023368872
55:metal-organic frameworks
1104:S.L. Schreiber (2009).
426:10.1023/A:1008184403558
257:J.M.J. Fréchet (2003).
123:combinatorial chemistry
89:Virtual building blocks
994:10.1002/ejoc.201300121
958:10.1002/anie.200600449
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183:An anti-diabetic drug
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570:Nat. Rev. Drug Discov
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749:Drug Discovery Today
648:Drug Discovery Today
371:Adv. Drug Deliv. Rev
205:H.H. Szmant (1989).
137:Building blocks and
1122:2009Natur.457..153S
1048:2004RuCRv..73..785K
915:2000Sci...287.1960D
909:(5460): 1960–1964.
825:(18): 16–18. 2011.
457:J. Chem. Inf. Model
418:2000JCAMD..14..487S
275:2003JPoSA..41.3713F
71:medicinal chemistry
284:10.1002/pola.10952
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174:diversity-oriented
107:biological targets
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1007:I. Ojima (2009).
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103:virtual screening
47:functional groups
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170:amino acid
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