1086:
371:
Older literature often uses ambiguous names such as pyridine nucleotide transhydrogenase, transhydrogenase, NAD(P)+ transhydrogenase, nicotinamide nucleotide transhydrogenase, NADPH-NAD+ transhydrogenase, pyridine nucleotide transferase, or NADPH-NAD+ oxidoreductase, which can equally apply to the
340:. In living cells this enzyme primarily operates in the direction consuming NADPH and producing NADH, as the physiological ratio of NADPH/NADP is much higher than the ratio of NADH/NAD. Its chief function
271:
183:
542:
717:
740:
615:
368:. Other names in common use include non-energy-linked transhydrogenase, NAD(P)+ transhydrogenase (B-specific), and soluble transhydrogenase.
202:
572:
580:
559:
535:
294:
282:
597:
373:
337:
656:
763:
447:"The soluble and membrane-bound transhydrogenases UdhA and PntAB have divergent functions in NADPH metabolism of Escherichia coli"
195:
528:
302:
146:
1126:
406:"Overexpression and biochemical characterization of soluble pyridine nucleotide transhydrogenase from Escherichia coli"
491:
You KS (1985). "Stereospecificity for nicotinamide nucleotides in enzymatic and chemical hydride transfer reactions".
805:
641:
576:
555:
298:
286:
1111:
753:
1116:
632:
140:
122:
961:
688:
683:
678:
127:
772:
310:
256:
207:
1076:
115:
1062:
1049:
1036:
1023:
1010:
997:
984:
946:
636:
50:
956:
910:
853:
563:
278:
232:
33:
143:
858:
646:
627:
306:
67:
1121:
329:
879:
798:
951:
520:
103:
8:
915:
325:
290:
45:
79:
848:
730:
333:
38:
158:
1106:
508:
468:
427:
422:
405:
247:
134:
894:
889:
863:
791:
500:
458:
417:
356:, specifically those acting on NADH or NADPH with NAD+ or NADP+ as acceptor. The
941:
925:
838:
357:
162:
1090:
979:
920:
705:
700:
551:
353:
178:
504:
1100:
884:
843:
668:
153:
833:
472:
463:
446:
431:
220:
512:
1057:
992:
828:
235:
91:
1031:
1005:
243:
1085:
744:
721:
110:
445:
Sauer U, Canonaco F, Heri S, Perrenoud A, Fischer E (Feb 2004).
1044:
814:
660:
239:
190:
86:
74:
62:
324:-specific transhydrogenase is a soluble protein found in some
1018:
673:
619:
550:
98:
783:
444:
1074:
259:
265:
1098:
799:
536:
404:Cao Z, Song P, Xu Q, Su R, Zhu G (Jul 2011).
399:
397:
403:
806:
792:
543:
529:
394:
336:are known to possess both a soluble and a
462:
421:
316:
438:
1099:
344:is the reoxidization of excess NADPH.
303:nicotinate and nicotinamide metabolism
787:
524:
352:This enzyme belongs to the family of
493:CRC Critical Reviews in Biochemistry
490:
451:The Journal of Biological Chemistry
266:{\displaystyle \rightleftharpoons }
13:
483:
14:
1138:
1084:
754:Trimethylamine-N-oxide reductase
423:10.1111/j.1574-6968.2011.02287.x
347:
338:membrane-bound transhydrogenase
301:. This enzyme participates in
260:
1:
689:Neutrophil cytosolic factor 4
684:Neutrophil cytosolic factor 2
679:Neutrophil cytosolic factor 1
642:NADPH—cytochrome-c2 reductase
387:
773:NADH dehydrogenase (quinone)
7:
813:
633:NADPH—hemoprotein reductase
362:NADPH:NAD+ oxidoreductase (
10:
1143:
1127:Enzymes of known structure
970:
962:Michaelis–Menten kinetics
934:
903:
872:
821:
762:
739:
716:
655:
637:Cytochrome P450 reductase
614:
598:NAD(P) transhydrogenase (
589:NAD(P) transhydrogenase (
571:
505:10.3109/10409238509113625
410:FEMS Microbiology Letters
374:NAD(P) transhydrogenase (
225:NAD(P) transhydrogenase (
201:
189:
177:
172:
168:
152:
133:
121:
109:
97:
85:
73:
61:
56:
44:
32:
27:
19:NAD(P) transhydrogenase (
18:
854:Diffusion-limited enzyme
1112:NADPH-dependent enzymes
647:Leghemoglobin reductase
628:Methemoglobin reductase
1117:NADH-dependent enzymes
464:10.1074/jbc.M311657200
330:gram-positive bacteria
317:Physiological function
267:
947:Eadie–Hofstee diagram
880:Allosteric regulation
268:
957:Lineweaver–Burk plot
257:
326:Gammaproteobacteria
281:of this enzyme are
916:Enzyme superfamily
849:Enzyme promiscuity
731:NADH dehydrogenase
360:of this enzyme is
334:Enterobacteriaceae
305:. It employs one
289:, whereas its two
263:
1072:
1071:
781:
780:
248:chemical reaction
217:
216:
213:
212:
116:metabolic pathway
1134:
1089:
1088:
1080:
952:Hanes–Woolf plot
895:Enzyme activator
890:Enzyme inhibitor
864:Enzyme catalysis
808:
801:
794:
785:
784:
545:
538:
531:
522:
521:
516:
477:
476:
466:
442:
436:
435:
425:
401:
272:
270:
269:
264:
170:
169:
16:
15:
1142:
1141:
1137:
1136:
1135:
1133:
1132:
1131:
1097:
1096:
1095:
1083:
1075:
1073:
1068:
980:Oxidoreductases
966:
942:Enzyme kinetics
930:
926:List of enzymes
899:
868:
839:Catalytic triad
817:
812:
782:
777:
758:
735:
712:
651:
610:
567:
552:Oxidoreductases
549:
519:
486:
484:Further reading
481:
480:
443:
439:
402:
395:
390:
358:systematic name
354:oxidoreductases
350:
319:
258:
255:
254:
12:
11:
5:
1140:
1130:
1129:
1124:
1119:
1114:
1109:
1094:
1093:
1070:
1069:
1067:
1066:
1053:
1040:
1027:
1014:
1001:
988:
974:
972:
968:
967:
965:
964:
959:
954:
949:
944:
938:
936:
932:
931:
929:
928:
923:
918:
913:
907:
905:
904:Classification
901:
900:
898:
897:
892:
887:
882:
876:
874:
870:
869:
867:
866:
861:
856:
851:
846:
841:
836:
831:
825:
823:
819:
818:
811:
810:
803:
796:
788:
779:
778:
776:
775:
769:
767:
760:
759:
757:
756:
750:
748:
737:
736:
734:
733:
727:
725:
714:
713:
711:
710:
709:
708:
706:Dual oxidase 2
703:
701:Dual oxidase 1
693:
692:
691:
686:
681:
676:
665:
663:
653:
652:
650:
649:
644:
639:
630:
624:
622:
612:
611:
609:
608:
595:
585:
583:
569:
568:
548:
547:
540:
533:
525:
518:
517:
499:(4): 313–451.
487:
485:
482:
479:
478:
437:
392:
391:
389:
386:
349:
346:
318:
315:
277:Thus, the two
275:
274:
262:
215:
214:
211:
210:
205:
199:
198:
193:
187:
186:
181:
175:
174:
166:
165:
156:
150:
149:
138:
131:
130:
125:
119:
118:
113:
107:
106:
101:
95:
94:
89:
83:
82:
77:
71:
70:
65:
59:
58:
54:
53:
48:
42:
41:
36:
30:
29:
25:
24:
9:
6:
4:
3:
2:
1139:
1128:
1125:
1123:
1122:Flavoproteins
1120:
1118:
1115:
1113:
1110:
1108:
1105:
1104:
1102:
1092:
1087:
1082:
1081:
1078:
1064:
1060:
1059:
1054:
1051:
1047:
1046:
1041:
1038:
1034:
1033:
1028:
1025:
1021:
1020:
1015:
1012:
1008:
1007:
1002:
999:
995:
994:
989:
986:
982:
981:
976:
975:
973:
969:
963:
960:
958:
955:
953:
950:
948:
945:
943:
940:
939:
937:
933:
927:
924:
922:
921:Enzyme family
919:
917:
914:
912:
909:
908:
906:
902:
896:
893:
891:
888:
886:
885:Cooperativity
883:
881:
878:
877:
875:
871:
865:
862:
860:
857:
855:
852:
850:
847:
845:
844:Oxyanion hole
842:
840:
837:
835:
832:
830:
827:
826:
824:
820:
816:
809:
804:
802:
797:
795:
790:
789:
786:
774:
771:
770:
768:
765:
761:
755:
752:
751:
749:
746:
742:
738:
732:
729:
728:
726:
723:
719:
715:
707:
704:
702:
699:
698:
697:
694:
690:
687:
685:
682:
680:
677:
675:
672:
671:
670:
669:NADPH oxidase
667:
666:
664:
662:
658:
654:
648:
645:
643:
640:
638:
634:
631:
629:
626:
625:
623:
621:
617:
613:
607:
605:
601:
596:
594:
592:
587:
586:
584:
582:
578:
574:
570:
565:
561:
557:
553:
546:
541:
539:
534:
532:
527:
526:
523:
514:
510:
506:
502:
498:
494:
489:
488:
474:
470:
465:
460:
457:(8): 6613–9.
456:
452:
448:
441:
433:
429:
424:
419:
415:
411:
407:
400:
398:
393:
385:
383:
381:
377:
369:
367:
365:
359:
355:
345:
343:
339:
335:
331:
327:
323:
314:
312:
308:
304:
300:
296:
292:
288:
284:
280:
252:
251:
250:
249:
245:
241:
237:
234:
230:
228:
222:
209:
206:
204:
200:
197:
194:
192:
188:
185:
182:
180:
176:
171:
167:
164:
160:
157:
155:
154:Gene Ontology
151:
148:
145:
142:
139:
136:
132:
129:
126:
124:
120:
117:
114:
112:
108:
105:
102:
100:
96:
93:
92:NiceZyme view
90:
88:
84:
81:
78:
76:
72:
69:
66:
64:
60:
55:
52:
49:
47:
43:
40:
37:
35:
31:
26:
22:
17:
1058:Translocases
1055:
1042:
1029:
1016:
1003:
993:Transferases
990:
977:
834:Binding site
696:dual oxidase
695:
603:
599:
590:
588:
496:
492:
454:
450:
440:
413:
409:
379:
375:
372:more common
370:
363:
361:
351:
348:Nomenclature
341:
321:
320:
276:
253:NADPH + NAD
226:
224:
221:biochemistry
218:
80:BRENDA entry
20:
829:Active site
745:Nitrogenous
416:(1): 9–14.
273:NADP + NADH
68:IntEnz view
28:Identifiers
1101:Categories
1032:Isomerases
1006:Hydrolases
873:Regulation
724:or similar
606:-specific)
593:-specific)
388:References
382:-specific)
366:-specific)
279:substrates
229:-specific)
137:structures
104:KEGG entry
51:9014-18-0
23:-specific)
911:EC number
261:⇌
244:catalyzes
57:Databases
1107:EC 1.6.1
935:Kinetics
859:Cofactor
822:Activity
674:P91-PHOX
473:14660605
432:21545646
307:cofactor
291:products
238:) is an
208:proteins
196:articles
184:articles
141:RCSB PDB
1091:Biology
1045:Ligases
815:Enzymes
766:: other
722:Quinone
513:3157549
342:in vivo
236:1.6.1.1
163:QuickGO
128:profile
111:MetaCyc
46:CAS no.
39:1.6.1.1
1077:Portal
1019:Lyases
764:1.6.99
661:Oxygen
511:
471:
430:
240:enzyme
191:PubMed
173:Search
159:AmiGO
147:PDBsum
87:ExPASy
75:BRENDA
63:IntEnz
34:EC no.
971:Types
747:group
741:1.6.6
718:1.6.5
657:1.6.3
616:1.6.2
573:1.6.1
560:NADPH
283:NADPH
242:that
123:PRIAM
1063:list
1056:EC7
1050:list
1043:EC6
1037:list
1030:EC5
1024:list
1017:EC4
1011:list
1004:EC3
998:list
991:EC2
985:list
978:EC1
620:Heme
581:NADP
566:1.6)
556:NADH
509:PMID
469:PMID
428:PMID
328:and
299:NADH
297:and
295:NADP
293:are
285:and
246:the
203:NCBI
144:PDBe
99:KEGG
577:NAD
558:or
501:doi
459:doi
455:279
418:doi
414:320
311:FAD
287:NAD
219:In
179:PMC
135:PDB
1103::
743::
720::
659::
618::
604:Si
600:Re
591:Si
575::
564:EC
554::
507:.
497:17
495:.
467:.
453:.
449:.
426:.
412:.
408:.
396:^
384:.
380:Si
376:Re
364:Si
332:.
322:Si
313:.
309:,
233:EC
227:Si
223:,
161:/
21:Si
1079::
1065:)
1061:(
1052:)
1048:(
1039:)
1035:(
1026:)
1022:(
1013:)
1009:(
1000:)
996:(
987:)
983:(
807:e
800:t
793:v
635:/
602:/
579:/
562:(
544:e
537:t
530:v
515:.
503::
475:.
461::
434:.
420::
378:/
231:(
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