552:
cortical regions responsible for memory and higher cognitive functions, respectively, show significant GSH depletion, leading to cognitive decline. Using 31P MRS, scientists discovered that pH of the left hippocampal formation in AD shifts towards alkalinity. Research has also demonstrated the existence of two open-and-closed conformations of GSH in healthy young participants. Presently, they are investigating the role of two GSH conformations and link between iron deposition and oxidative stress (OS) in the hippocampal formation in AD. Although the exact cause of AD remains unknown, OS is considered a potential factor. Additionally, researchers at NBRC have proposed a novel prospective single-center parallel-arm double-blinded placebo-controlled phase III randomized trial using GSH as a dietary supplement for MCI patients, while monitoring brain GSH levels and cognitive profile using non-invasive MRS and neuropsychological testing, respectively.
92:
534:: This was developed as an advanced automated neuro-tool to aid the early diagnosis of AD. This tool consists of several computer-assisted tools for data pre-processing, quality control, data preparation, analysis, evaluation, and assessment. The fundamental objective of this proposal is to benefit the Indian population by developing a comprehensive neuro-tool. It provides a scheme for MRI-, MRS-, and fMRI-based data generation, processing scheme of multimodal neuroimaging and neuro-spectroscopy data in a single window to achieve a conclusive outcome for the early diagnosis of brain disorders.
627:
replication and virulence. The study investigated whether
Glycyrrhizin affects SARS-CoV-2 S-RBD- and Orf3a-mediated HMGB1 release and cell death in lung cells expressing SARS-CoV-2 viral proteins. Glycyrrhizin did not only reverse S-RBD- and Orf3a-induced extracellular HMGB1 release but also abrogated caspase-1 activation and rescued cell death. Benefits of anti-inflammatory properties in glycyrrhizin are: 1) Lowering the severity of the disease, 2) Mitigating viral replication by as much as 90%, and 3) Fighting the "storm of cytokines".
455:: This is a national level multi-centric program that provides insights into the prevalence of dementia and discover biomarkers, risk factors, and protective factors. These factors play a major role in the conversion of MCI to dementia among elderly. For the diagnosis and classification of dementia, all centers use robust uniform criteria that are internationally accepted, adapted, and validated in the Indian context. Findings could help formulate national-level policies for understanding and treating MCI in elderly.
741:: NBRC is surrounded by keekar forests of Aravalli mountain range. From its inception, NBRC has been maintaining the surrounding jungle and has planted several trees and shrubs in the campus. There are over 100 different kinds of birds in and around NBRC, such as Jungle Babbler, Oriental Magpie Robin, Bulbul, Collared Dove, Rose-ringed Parakeet, Drongo, and Indian Peafowls. Several bird-watching programs are conducted regularly for students and staff.
564:
spectroscopic, and behavioral changes in the brains of recovered/asymptomatic patients using a novel non-invasive MRS neuroimaging technique. Findings suggest that glutamate and GABA levels are potential parameters to monitor mental health and psychiatric disease-associated conditions. Moreover, antioxidants and neurotransmitters in the study have potential implications for psychiatric disorders in COVID-19-affected patients.
24:
645:: This animal facility is registered with the Committee for the Purpose of Control and Supervision of Experiments on Animals, Ministry of Environment and Forests, Government of India, New Delhi. The facility contains animal models, including primates and transgenic mice. Detailed training programs for veterinary and husbandry care and peer-reviewed evaluation of all protocols are followed.
461:: This flagship program understands how information-processing networks in the brain are affected in CMD, including anxiety, depression, obsessive-compulsive disorder, and post-traumatic stress disorder. The program also studies underlying brain mechanisms that differentiate between these disorders, and whether these networks are affected in the same manner in different age groups.
576:
highlights the importance of subcortical areas even during stimulus independent processing. Outcomes lead to understanding the crucial role of the thalamus as a major integrative hub in addition to insular network for mediating key cognitive functional dynamics and their role during maintenance of cognitive functions during healthy aging process in the human brain.
674:: This is an initiative by DBT that gives unlimited access to most of the relevant periodicals to researchers. It gives access to high-quality e-resources. It provides current (1000+ online resources) and archival access to >1176 core peer-reviewed journals and one bibliographic database (SCOPUS) in different disciplines from 21 foreign publishers.
311:, was established in 2005. Two major flagship programs by NBRC were initiated in the past few years. By 2017, National Dementia Program was initiated under NBRC's leadership, whereas by 2019, a flagship program entitled "Comparative mapping of common mental disorders (CMD) over the lifespan" was launched to understand the science of well-being.
599:
This study focused on delineating molecular mechanisms, role of miRNAs, and involvement of ZV E protein in ZV-induced microcephaly. The protein promotes premature but faulty formation of neurons, which affects normal properties of brain stem cells. This is the potential reason behind ZV-induced small
626:
An active ingredient
Glycyrrhizin in Mulethi (liquorice)—a commonly used herb—is a potential source for the development of a drug against COVID-19. HMGB1 is crucial for regulating susceptibility to SARS-CoV-2, whereas S-receptor binding body (RBD) and Orf3a proteins are required for maximal SARS-CoV
575:
Scientists studied the specific role of the human thalamus as causal outflow hub in reorganizing directed information flow and connectivity among large-scale major neurocognitive networks during brain aging. This reorganization of directed functional connectivity with age during spontaneous activity
614:
This work on focused on the regeneration of nervous system, wherein lost neuronal function was found to be restored after injury in roundworm model. The findings established that the axon fusion process has functional significance in the maintenance of neuronal integrity throughout the life span of
439:. The research focuses on detailed understanding of our senses of touch, hearing, speech learning, memory, and spatial navigation. Moreover, basic research helps plan clinical trials for the development of rational therapy for brain disorders. Researchers have also been studying the implications of
306:
recording. In the following year, a
Translational and Clinical Neuroscience Unit was formed along with a Neurology Outpatient Department to Civil Hospital, Gurgaon, to help common people and assess the occurrence of neurological cases in this region. Further, the Centre of Excellence for Epilepsy,
269:
The
National Brain Research Centre (NBRC) is India's only institute dedicated to neuroscience research and education. The institute's primary objectives are to understand brain functions in both healthy and diseased states, train human resources capable of conducting interdisciplinary research in
587:
In this collaborative study, it was discovered that dengue and JE viruses activate platelet inside host and induce them release platelet factor 4 (PF4). PF4 inhibits the activity of immune cells, thus stopping interferon production. PF4 acts through its receptor CXCR3, which when blocked with an
551:
Scientists have been studying the early biomarkers for AD using brain chemicals. Monitoring glutathione (GSH), an antioxidant molecule in the brain, aids in the early identification of AD and mapping out therapeutic invention. Scientists have demonstrated that hippocampus, frontal, and cingulate
563:
Considering the elevating cases of depression, obsessive-compulsive disorder, anxiety, and post-traumatic stress disorder in patients with COVID-19, scientists have been mapping brains of patients who recovered from or were asymptomatic to COVID-19. This first global study analyzed structural,
330:
Bachelor's degree or equivalent in any branch of science such as Life
Sciences / Physics / Chemistry / Mathematics / Statistics / Computer applications / Pharmacy / Veterinary Science / Psychology / Engineering / Technology / Medicine from a recognized Institute /
504:: The integration of data gathered from multimodal brain imaging systems at various Regions of Interest (ROIs) avails wealth of information about tissue microenvironment and its association with structural and functional changes in healthy or diseased condition.
528:: Scientists have developed a well-characterized model of human neural stem cells (hNSCs) to understand cellular–molecular functions of healthy and diseased brain. The NSCs work has been expanded by establishing a human inducible pluripotent cells platform.
516:: A methodical system that uses adaptive pattern recognition and learning schemes for predictive single or differential diagnosis of diseases, such as Alzheimer's and Parkinson's Disease, designed with MRI modalities and neuropsychological batteries.
274:, and promote neuroscience in India by networking with national institutions. Scientists and students at NBRC come from diverse academic backgrounds, including biological, computational, mathematical, physical, engineering, and medical sciences.
282:
On 5 October 1995, the proposal for founding NBRC was put forward. The creation was subsequently declared on 14 November 1997 as a part of the Golden
Jubilee celebrations of India's Independence and the birth date of the former Prime Minister,
363:
Minimum 55% (50% for SC / ST / PH candidates) marks or equivalent grade or grade point average from the secondary (10th) examination onwards is required. Candidates should calculate their percentage up to two decimal points to determine their
337:
Minimum 55% (50% for SC / ST / PH candidates) marks or equivalent grade or grade point average from secondary (10th) examination onwards is required. Candidates should calculate their percentage up to two decimal points to determine their
656:: This laboratory functions on the metabolic analysis of different neurodegenerative disorders (e.g., AD, PD) using MRS technique to identify biomarkers in and measure quantitative stress of age-matched healthy adults and patients.
353:
Master's degree or equivalent in any branch of science, such as Life
Sciences / Physics / Chemistry / Mathematics / Statistics / Computer applications / Pharmacy / Veterinary Science / Psychology from a recognized Institute /
639:: DIC is established under the initiative of BTISNET initiative of DBT. DIC manages information and communications technology (ICT) and e-governance activities of NBRC. It provides ICT science & technology services.
735:: In February 2021, GCC was constituted for spreading environmental awareness and education through eco-friendly environmental development programs, focusing on using sustainable energy to reduce carbon footprint.
692:: This unit provides neurological OPD services and assesses the occurrence of neurological cases in Gurgaon. Patients visiting the unit have access to several facilities, including MRI, computed tomography, etc.
600:
head size in infants. Nearly 25 miRNAs, regulating genes and protein expression in cells, were identified as important factors impacting the cell division, proliferation and stemness of the brain stem cells.
498:: A multimodality-based Hadoop-based big data decision framework, validated using fMRI, integrates non-invasive MRI, MRS, and neuropsychological test outcomes to identify early diagnostic biomarkers of AD.
326:
NBRC has integrated multidisciplinary teaching programmes in Life
Sciences, such as 2-year M.Sc. program in Neuroscience with broad overview of different aspects of Neuroscience. Eligibility criteria:
717:: NBRC is connected to New Delhi and Jaipur via NH8. NBRC provides transport services, including bus and car, to students and staff. For those staying off-campus, daily shuttle services are provided.
203:
480:: An integrative package for visualization, preprocessing, and quantitation of MR spectroscopy (MRS) data acquired using MRS imaging and MEshcher-Garwood–Point-RESolved Spectroscopy (MEGA-PRESS).
349:
NBRC offers 5-year Ph.D. program in
Neuroscience to students from diverse backgrounds who have a master's degree in any branch related to Neuroscience as mentioned below: Eligibility criteria:
668:: The library consists of automated open-access system and provides information services and access to bibliographical and full-text digital and printed resources for on-campus user community.
287:. A Management Advisory Committee was further formed. In 2000, the institute commenced functioning as an autonomous institute of the Department of Biotechnology from its temporary location at
486:: A MATLAB-based statistical analysis toolbox: A high-performance state-of-the-art automated statistical test selection and execution software package with clinical research applications.
357:
Students who have done a minimum of four-years of course-work leading to a bachelor's degree or equivalent in
Engineering / Technology / Medicine from a recognized Institute / University
686:: The unit works on imaging-based diagnosis of neurodegenerative diseases and planning pulsed radiotherapy and chemotherapy for treating brain tumors from translational medicine aspect.
522:: ANSH database brings critical neurochemical information from HO, MCI, and AD patients to facilitate collaborative research and multi-site global data sharing for comparative analysis.
291:, New Delhi. NBRC was awarded the status of Deemed University by Ministry of Education in 2002. On 16 December 2003, NBRC was moved to the foothills of the Aravalli Range in Manesar.
711:: NBRC has a full-time resident medical officer as well as on-site OPD service. In case of medical emergencies, a full-time transport system transports patients to nearest hospitals.
510:: A synchronized system to be used in fMRI for mapping brain activity non-invasively in various conditions for normal healthy as well as for clinical evaluation with brain disorders.
474:: A package developed using screening tools, remediation kit, and specific assessment tools to identify dyslexia. It integrates four languages (Hindi, Kannada, Marathi, and English).
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407:. Nevertheless, faculty collaborates across divisions and other scientists. Research develops therapeutic tools and platforms to assess and cure brain disorders, including
34:
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Research faculty studies the complexities of brain functions and cognition in health and diseases. Research at NBRC is organized into five divisions: 1)
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antagonist AMG487 inhibits dengue and JE replication both in vivo and in vitro. This study indicates the possibility of developing an antiviral agent.
375:
NBRC conducts summer training programs wherein trainees attend seminars and journal clubs organized at the institute and get exposure to neuroscience.
1620:"Reconfiguration of Directed Functional Connectivity Among Neurocognitive Networks with Aging: Considering the Role of Thalamo-Cortical Interactions"
864:"KALPANA: Advanced Spectroscopic Signal Processing Platform for Improved Accuracy to Aid in Early Diagnosis of Brain Disorders in Clinical Setting"
492:: First accurate high-resolution brain template developed for analyzing structural and functional neuroimaging data specific for Indian population.
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and brain functions in health and diseases using multidisciplinary approaches. This is the first autonomous institute by DBT to be awarded by the
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729:: This student-organized annual event, including several competitions and programmes, is hosted by second-year Ph.D. students for newcomers.
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In the year 2006, National Neuroimaging facility was established that was fully equipped with state-of-the-art equipment, such as a 3 tesla
49:
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an organism. The researchers also demonstrated how to control this process genetically for treating nerve injuries in humans in future.
130:
1253:
987:"BRAHMA: Population specific T1, T2, and FLAIR weighted brain templates and their impact in structural and functional imaging studies"
1357:"ANSH: Multimodal Neuroimaging Database Including MR Spectroscopic Data From Each Continent to Advance Alzheimer's Disease Research"
771:
1745:"let-7 miRNA controls CED-7 homotypic adhesion and EFF-1–mediated axonal self-fusion to restore touch sensation following injury"
308:
1804:"Glycyrrhizin prevents SARS-CoV-2 S1 and Orf3a induced high mobility group box 1 (HMGB1) release and inhibits viral replication"
662:: This center studies epileptogenesis, better diagnosis, and localization of epileptogenic foci and new therapeutic techniques.
620:
Glycyrrhizin prevents SARS-CoV-2 S1 and Orf3a induced high mobility group box 1 (HMGB1) release and inhibits viral replication
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680:: Research in this lab focuses on unravelling cortical pathways involved in Hindi–English biscriptal adults and children.
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miRNA controls CED-7 homotypic adhesion and EFF-1-mediated axonal self-fusion to restore touch sensation following injury
231:
71:
1571:"Brain Stress Mapping in COVID-19 Survivors Using MR Spectroscopy: New Avenue of Mental Health Status Monitoring"
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Role of thalamo cortical interactions in reorganization of directed information flow with aging in brain networks
53:
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266:
was followed by Prof. Subrata Sinha and Prof. Neeraj Jain. The current director of NBRC is Prof. Krishanu Ray.
1696:"Zika virus E protein alters the properties of human fetal neural stem cells by modulating microRNA circuitry"
1442:"Hippocampal Glutathione Depletion and pH Increment in Alzheimer's Disease: An in vivo MR Spectroscopic Study"
2004:
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ZV envelop (E) protein alters properties of human fetal neural stem cells by modulating microRNA circuitry
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723:: Outdoor and indoor sports, including football and table tennis, are organized by the Sports Committee.
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1281:"GAURI: A Method and a System Using Multi-modal Information for Early Detection of Alzheimer's Disease"
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404:
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1068:"BHARAT: An Integrated Big Data Analytic Model for Early Diagnostic Biomarker of Alzheimer's Disease"
1522:"A Multi-Center Study on Human Brain Glutathione Conformation using Magnetic Resonance Spectroscopy"
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Candidates appearing for the final year of the qualifying examination are also eligible to apply
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Candidates appearing for the final year of the qualifying examination are also eligible to apply
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1173:"PRATEEK: Integration of Multimodal Neuroimaging Data to Facilitate Advanced Brain Research"
1119:"PRATEEK: Integration of Multimodal Neuroimaging Data to Facilitate Advanced Brain Research"
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1254:"Artificial Intelligence For Early Detection of Alzheimer's? Indian Scientists Say Yes!"
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250:, formerly known as the Ministry of Human Resource Development, in May 2002. NBRC (
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Identification of protein that helps dengue and JE viruses to multiply inside host
1496:"Hippocampal pH rise towards alkalinity: A perfect storm for Alzheimer's disease"
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1819:
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Development of a well-characterized hNSC/iPSC-induced pluripotent cell platform
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705:: There are two on-campus hostel buildings and one building as staff quarters.
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1669:"Scientists identify protein that helps dengue and JE viruses to multiply"
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1415:"SWADESH: Comprehensive Database and Data Analytics for Brain Research"
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Comparative mapping of common mental disorders (CMD) over the lifespan
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in December 2003. The founder chairman of NBRC Society is Prof.
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was dedicated to the nation by the Honorable President of India
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International Centre for Genetic Engineering and Biotechnology
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1903:
911:"NINS-STAT: An Automated Statistical Software Package"
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Computational neuroscience and neuroimaging laboratory
1308:"New database to advance global Alzheimer's research"
52:, and by adding encyclopedic content written from a
790:. Dbtindia.nic.in. 14 November 1997. Archived from
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Autonomous Government Institute (Deemed University)
1340:: CS1 maint: DOI inactive as of September 2024 (
970:: CS1 maint: DOI inactive as of September 2024 (
847:: CS1 maint: DOI inactive as of September 2024 (
472:Dyslexia Assessment for Languages of India (DALI)
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660:Centre for Excellence for Epilepsy/MEG facility
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2055:"National Brain Research Centre Manesar IN-HR"
690:Translational & clinical neuroscience unit
654:Neuroimaging and neurospectroscopy laboratory
238:. The institute is dedicated to research in
938:"New tool to decode brain images of Indians"
696:
672:DBT's Electronic Library Consortium (DeLCON)
465:
446:
226:. It is an autonomous institute under the
1930:"BTISNET - Distributed Information Centre"
1852:"BTISNET - Distributed Information Centre"
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557:Brain stress mapping in COVID-19 survivors
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344:Doctor of Philosophy (Ph.D. Neuroscience)
72:Learn how and when to remove this message
1934:Biotechnology Information System Network
1856:Biotechnology Information System Network
1569:Samkaria, Avantika (14 September 2021).
1568:
1494:Mandal, Pravat Kumar (13 January 2021).
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545:Novel ways to tackle Alzheimer's Disease
508:Stimulus Timing Integrated Module (STIM)
2005:"National Brain Research Centre - NBRC"
1355:Mandal, Pravat Kumar (7 October 2021).
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309:All India Institute of Medical Sciences
2088:Neuroscience research centres in India
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678:Speech and Language Laboratory (SALLY)
321:Master of Science (M.Sc. Neuroscience)
33:contains content that is written like
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862:Mandal, Pravat Kumar (2 March 2020).
262:, whereas the founder director Prof.
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637:Distributed Information Center (DIC)
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1520:Shukla, Deepika (30 October 2018).
1041:"BRAHMA: The Indian Brain Template"
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788:"DBT - Department of Biotechnology"
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1743:Basu, Atrayee (21 November 2017).
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1440:Shukla, Deepika (September 2021).
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1066:Sharma, Ankita (8 February 2019).
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232:Ministry of Science and Technology
131:Minister of Science and Technology
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1618:Das, Moumita (30 November 2020).
815:"A new tool for testing dyslexia"
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307:jointly administered by NBRC and
1878:"National Brain Research Centre"
1252:Sheriff, Ahmed (27 April 2018).
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1984:National Brain Research Centre
1700:Cell Death and Differentiation
1575:Journal of Alzheimer's Disease
1446:Journal of Alzheimer's Disease
1177:Journal of Alzheimer's Disease
1123:Journal of Alzheimer's Disease
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868:Journal of Alzheimer's Disease
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649:National neuroimaging facility
212:National Brain Research Centre
85:National Brain Research Centre
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1910:. Department of Biotechnology
1858:. Department of Biotechnology
1361:Frontiers in Neuroinformatics
1258:Community at the better india
1171:Mandal, Pravat Kumar (2021).
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2103:Organisations based in Delhi
2098:Deemed universities in India
2093:Research institutes in India
1802:Gowda, Pruthvi (June 2021).
1322:(inactive 13 September 2024)
952:(inactive 13 September 2024)
829:(inactive 13 September 2024)
643:Experimental animal facility
539:Major research breakthroughs
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1117:Goel, Anshika (July 2021).
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228:Department of Biotechnology
214:is a research institute in
112:; 27 years ago
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1820:10.1016/j.cyto.2021.155496
991:Magnetic Resonance Imaging
405:Translational neuroscience
401:Computational neuroscience
296:magnetic resonance imaging
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264:Vijayalakshmi Ravindranath
1955:"NBRC Gurgaon Facilities"
1712:10.1038/s41418-018-0163-y
1526:IOS Press Content Library
1374:10.3389/fninf.2020.571039
1003:10.1016/j.mri.2019.12.009
985:Pai, Praful (July 2020).
697:Campus and infrastructure
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447:Major research programmes
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453:Dementia Science Program
1770:10.1073/pnas.1704372114
1500:npj Science of Learning
1320:10.1038/nindia.2020.175
827:10.1038/nindia.2019.118
631:Facilities and services
1636:10.1093/cercor/bhaa334
1413:Mandal, Pravat Kumar.
1306:Mandal, Pravat Kumar.
1279:Mandal, Pravat Kumar.
1225:Mandal, Pravat Kumar.
1072:Frontiers in Neurology
1039:Mandal, Pravat Kumar.
950:10.1038/nindia.2020.45
936:Mandal, Pravat Kumar.
733:Green Canopy Committee
397:Cognitive neuroscience
389:Molecular neuroscience
300:electroencephalography
256:Dr. A.P.J. Abdul Kalam
1755:(47): E10206–E10215.
421:Japanese encephalitis
385:Cellular neuroscience
260:Prakash Narain Tandon
244:Ministry of Education
54:neutral point of view
1183:(1). nbrc: 305–317.
703:Hostel accommodation
393:Systems neuroscience
1761:2017PNAS..11410206B
1314:. Nature Springer.
944:. Springer Nature.
413:Parkinson's disease
409:Alzheimer's disease
248:Government of India
236:Government of India
135:Government of India
86:
46:promotional content
1673:India Science Wire
1588:10.3233/JAD-210287
1538:10.3233/JAD-180648
1458:10.3233/JAD-215032
1260:. the better india
1189:10.3233/JAD-210440
1135:10.3233/JAD-210440
880:10.3233/JAD-191351
709:Medical facilities
433:spinal cord injury
425:Zika virus disease
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