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1065:, Cancer Systems Biology Consortium, Oncology Models Forum, Barrett's Esophagus Translational Research Network, New Approaches to Synthetic Lethality for Mutant KRAS-Dependent Cancers, Molecular and Cellular Characterization of Screen-Detected Lesions, Fusion Oncoproteins in Childhood Cancers, and Cancer Tissue Engineering Collaborative.
1209:
Lead
Academic Participating Sites (LAPS) were chosen at 30 academic institutions for their ability to conduct clinical trials and screen a large number of participants and awarded grants to support the infrastructure and administration required for clinical trials. Most LAPS grant recipients are also
1967:
The change is being made primarily due to the leases expiring at EPN, EPS and a few other buildings on
Executive Blvd. The new buildings would house, in one facility, staff from those leased sites... NCI will continue to occupy floors 10 and 11 of Bldg. 31's A wing, as well as much of the 3rd floor,
1273:
A high correlation of cytotoxicity with compounds of known biological mechanism is often predictive of the drugs mechanism of action and thus a tool to aid in the drug development and testing. It also tells if there is any unique response of the drug which is not similar to any of the standard
1238:
The evolution of strategies at the NCI illustrates the changes in screening that have resulted from advances in cancer biology. The
Developmental Therapeutics Program (DTP) operates a tiered anti-cancer compound screening program with the goal of identifying novel chemical leads and biological
1190:
are one of the primary arms in the NCI's mission in supporting cancer research. There are currently 72 so-designated centers; 9 cancer centers, 56 comprehensive cancer centers, and 7 basic laboratory cancer centers. NCI supports these centers with grant funding in the form of P30 Cancer Center
1060:
DCB oversees approximately 2000 grants per year in the areas of cancer cell biology; cancer immunology, hematology, and etiology; DNA and chromosome aberrations; structural biology and molecular applications; tumor biology and microenvironment; and tumor metastasis. "Special
Research Programs"
1085:
DCTD supports eight research programs: The
Biometric Research Program, The Cancer Diagnosis Program, The Cancer Imaging Program, The Cancer Therapy Evaluation Program, The Developmental Therapeutics Program, The Radiation Research Program, The Translational Research Program, and The
1247:. Those passing certain thresholds are subjected to a 5 dose screen of the same 60 cell-line panel to determine a more detailed picture of the biological activity. A second phase screen establishes the maximum tolerable dosage and involves
1229:
In the
Molecular Target Program thousands of molecular targets have been measured in the NCI panel of 60 human tumor cell lines. Measurements include protein levels, RNA measurements, mutation status and enzyme activity levels.
1218:
The NCI Development
Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.
1191:
Support Grants to support shared research resources and interdisciplinary programs. Additionally, faculty at the cancer centers receive approximately 75% of the grant funding awarded by the NCI to individual investigators.
1765:, Chief, Laboratory of Cellular Oncology; NCI Principal Deputy Director, initial development, characterization, and clinical testing of the preventive virus-like particle-based HPV vaccines.
3088:
314:
1955: NCI established the
Clinical Trials Cooperative Group Program, which included several research networks that conducted cancer clinical research primarily under the sponsorship of NCI.
1507:
11th
Director, left to become President of the Case Institute of Health, Science, and Technology and later Executive Director of Global Health for the Bill & Melinda Gates Foundation.
2968:: NCI Dictionary of Cancer Terms (utilizing non-technical language) • NCI Dictionary of Genetics Terms (for healthcare professionals) • NCI Drug Dictionary (includes links for potential
3038:
203:
1150:
In the 1990s, the
Unconventional Innovation Program was created to integrate interdisciplinary technology research with biological applications. It was reorganized in 2004 as the CSSI.
3113:
3103:
376:
1968:
and the NCI director will remain in 31. There are also many staff members in lab buildings and the Clinical Center on campus and a large presence in Frederick at Ft. Detrick.
3138:
1423:
195:. The NCI conducts and supports research, training, health information dissemination, and other activities related to the causes, prevention, diagnosis, and treatment of
3093:
1823:
3366:
1104:
DEA processes and supports the thousands of grant applications NCI receives each year and compiles reports on the progress of research funded by the NCI's programs.
379:
encourages NCI to expand its efforts in prostate cancer, breast and other cancers which primarily or solely affected women, and authorized increased appropriations.
3422:
3184:
3098:
3143:
3024:
1385:
1087:
383:
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3108:
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107:
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1325:
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assay, unique structure, potency, and demonstration of a unique pattern of cellular cytotoxicity or cytostasis, indicating a unique mechanism of action or
2715:
3123:
275:
signed into law the National Cancer Institute Act (Pub. Law 75-244; 50 Stat. 559), which established the National Cancer Institute, as a division of the
3078:
2111:"National Cancer Institute Act: Text of the Act of August 5, 1937, creating the National Cancer Institute and authorizing an appropriation therefor".
3447:
1404:
366:
219:
138:
2994:
3437:
2337:
370:
266:
Members of the first National Advisory Cancer Council at the groundbreaking ceremonies of the NCI's building 6 in Bethesda, Maryland (June 1938)
3128:
1210:
NCI-designated cancer centers. NCTN also stores surgical tissue from patients in a nationwide network of tissue banks at various universities.
1202:
The National Clinical Trials Network (NCTN) was formed in 2014, from the Cooperative Group program to modernize the existing system to support
394:
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3199:
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2686:
3017:
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3452:
3153:
967:
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2220:
3068:
2733:
1830:
311:, to broaden the scope and responsibilities of the NCI "in order more effectively to carry out the national effort against cancer."
284:
2184:
2930:
1206:
clinical trials. With precision medicine, many patients must be screened to determine eligibility for treatments in development.
329:
60:
3427:
3417:
3376:
3148:
3010:
971:
2657:
1836:
422:
was sworn in as the 15th director of the National Cancer Institute. In April 2019, Sharpless left NCI to serve as the acting
2985:
2256:
362:
declares "war on cancer," establishes the National Cancer Advisory Board, and allots additional funding for cancer research.
3442:
3381:
3361:
3179:
1436:
1351:
3386:
3351:
3225:
3133:
2154:
1379:
415:
increased funding for biomedical research. The "Cancer Moonshot" program promised additional support for cancer research.
276:
2924:
1814:, the Cancer BioInformatics Grid, a National Cancer Institute (USA) initiative to link cancer researchers and their data
1239:
mechanisms. The DTP screen is a three phase screen which includes: an initial screen which first involves a single dose
2634:
2606:
2578:
1062:
3169:
1561:
3432:
3118:
2484:
2860:
3356:
1176:
436:
211:
2885:
1806:
1604:
1528:
423:
2055:
3034:
2001:
1720:
1580:
296:
188:
133:
117:
1660:
241:
with a dedicated focus on cancer research and treatment and maintains the National Clinical Trials Network.
3174:
2672:"Dr. Richard D. Klausner Named Executive Director of Global Health for Bill & Melinda Gates Foundation"
1841:
1187:
238:
3073:
359:
308:
206:($ 6.9 billion in 2020). It fulfills the majority of its mission via an extramural program that provides
963:
2412:
1817:
2629:
3258:
2025:
1262:
Active compounds are selected for testing based on several criteria: disease type specificity in the
304:
300:
2286:
1986:
1222:
Under the label "Discovery & Development Services" several services are offered, among them the
3371:
3293:
2301:
1952:
1519:
2531:
3283:
3194:
1127:
3278:
3058:
2810:
1905:
1461:
1342:
412:
292:
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3220:
2097:
556:
272:
3002:
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1704:
1366:
536:
399:
387:
2362:
2231:
2072:
1785:, chief scientist at Cancer Biomarkers Research Group of the Division of Cancer Prevention
1194:
The NCI cancer centers program was introduced in 1971 with 15 participating institutions.
1025:
The CCR includes approximately 250 internal NCI research groups in Frederick and Bethesda.
8:
3303:
1543:
1499:
1256:
1255:
regression using the hollow fiber assay. The third phase of the study is the human tumor
927:
485:
227:
3328:
2956:
2950:
2835:
2788:
2274:
1974:
1883:
1756:
1714:
1619:
1203:
885:
731:
344:
340:
215:
161:
73:
1633:
1613:
199:; the supportive care of cancer patients and their families; and cancer survivorship.
3288:
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3253:
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2768:
2309:
2136:
2128:
1782:
2430:
1474:
3313:
3230:
2965:
2918:
2195:
2120:
1745:
1730:
1681:, NIH Distinguished Investigator and Director of the NCI Center for Cancer Research
1672:
1595:
751:
461:
444:
419:
2886:"W. Kimryn Rathmell begins work as 17th director of the National Cancer Institute"
1589:
1455:
1300:
355:, to house research activities on the causes, treatment, and prevention of cancer.
3323:
3308:
3263:
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2333:
2258:
December 13, 2016—Important Events in NCI History—National Cancer Institute (NCI)
1762:
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897:
864:
318:
93:
26:
262:
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1336:
1041:
DCEG is made up of eight branches within the Trans-divisional Research Program.
907:
654:
518:
512:
491:
2975:
1753:, Chief of the Experimental Immunology Branch of the National Cancer Institute
3411:
2313:
2132:
1750:
1740:
1567:
1480:
1306:
1267:
989:
604:
440:
336:
2448:
2124:
202:
NCI is the oldest and has the largest budget and research program of the 27
2789:"NCI Director Dr. Norman E. Sharpless—Director's Page—Leadership—About NCI"
2466:
2140:
1884:"NCI Director Dr. Norman E. Sharpless—Director's Page—Leadership—About NCI"
1776:
1725:
1699:
1689:
1666:
1493:
1240:
932:
917:
814:
757:
524:
451:
348:
322:
223:
187:) coordinates the United States National Cancer Program and is part of the
2302:"National Cancer Chief, Ned Sharpless, Named F.D.A.'s Acting Commissioner"
2162:
1527:
12th Director, served from 2001 to 2006 before transitioning to a role as
736:
2997:
2155:"Statutes at Large Volume 50 (1937) Table of Contents; VOL. 49 – VOL. 51"
1930:
1678:
1576:
848:
844:
824:
778:
747:
740:
644:
634:
614:
594:
587:
562:
546:
2492:
2399:
Division of Cancer Epidemiology and Genetics – National Cancer Institute
1417:
3345:
3273:
2716:"U.S. Senate: U.S. Senate Roll Call Votes 109th Congress – 2nd Session"
1694:
949:
901:
891:
834:
828:
818:
802:
721:
698:
688:
668:
664:
638:
579:
568:
530:
501:
207:
3089:
National Institute of Arthritis and Musculoskeletal and Skin Diseases
1537:
1319:
993:
957:
868:
854:
838:
808:
792:
788:
715:
706:
678:
674:
648:
628:
624:
618:
477:
210:
for cancer research. Additionally, the National Cancer Institute has
2513:
1579:
for studies of the genetic basis of cancer. He was director of the
1263:
1252:
953:
858:
772:
768:
761:
718:
608:
575:
471:
455:
352:
77:
1861:
1398:
2678:
1675:
was the Chief of the Laboratory of Chemoprevention, 1978 to 1995.
1513:
1360:
1248:
937:
911:
879:
875:
712:
598:
495:
481:
465:
3114:
National Institute of Diabetes and Digestive and Kidney Diseases
3104:
National Institute on Deafness and Other Communication Disorders
2811:"Dr Norman Edward Sharpless, MD, NIH Enterprise Directory (NED)"
2549:
1906:"Dr Norman Edward Sharpless, MD, NIH Enterprise Directory (NED)"
2380:
1244:
983:
921:
658:
196:
2485:"History – Center for Strategic Scientific Initiatives (CSSI)"
2338:"Statement on the return of Dr. Ned Sharpless as NCI Director"
1663:, senior investigator and radiation epidemiology branch chief.
583:
254:
3032:
1811:
1126:
CCG was created in 2011 and is responsible for management of
977:
694:
684:
540:
3139:
National Institute on Minority Health and Health Disparities
1116:
Center for Biomedical Informatics and Information Technology
426:. He returned to the institute in November 2019 as director.
191:(NIH), which is one of eleven agencies that are part of the
3094:
National Institute of Biomedical Imaging and Bioengineering
1032:
798:
782:
550:
505:
2944:
2573:
2394:
2033:
1824:
European Organisation for Research and Treatment of Cancer
1717:, head of the tumor microenvironment and metastasis branch
152:
1223:
1016:
3185:
National Center for Complementary and Integrative Health
3099:
National Institute of Child Health and Human Development
1627:
16th Director of NCI. First woman to hold the position.
3144:
National Institute of Neurological Disorders and Stroke
2754:"Director's Page – National Cancer Institute (Archive)"
1233:
1088:
Office of Cancer Complementary and Alternative Medicine
1007:
The NCI is divided into several divisions and centers.
384:
Office of Cancer Complementary and Alternative Medicine
3367:
National Institutes of Health Director's Pioneer Award
3109:
National Institute of Dental and Craniofacial Research
2927:. National Cancer Institute. Retrieved 18 August 2004.
2921:. National Cancer Institute. Retrieved 18 August 2004.
2756:. Cancer.gov. Archived from the original on 2015-03-31
258:
An early wooden sign for the National Cancer Institute
3084:
National Institute of Allergy and Infectious Diseases
1551:
13th Director of the NCI, was nominated by President
1213:
108:
United States Department of Health and Human Services
3190:
National Center for Advancing Translational Sciences
2980:
A Short History of the National Institutes of Health
1607:
in April 2019 and returned to NCI in November 2019.
404:
in additional funding for the NIH; the NCI received
3124:
National Institute of Environmental Health Sciences
2574:"Welcome to the Developmental Therapeutics Program"
1876:
1197:
3079:National Institute on Alcohol Abuse and Alcoholism
1945:
1603:15th Director of the NCI. Transitioned to acting
1072:Division of Cancer Control and Population Sciences
430:
2708:
1791:and Barry Rosenstein, lead investigators for the
367:Frederick National Laboratory for Cancer Research
220:Frederick National Laboratory for Cancer Research
3409:
2982:, an online exhibit by the Office of NIH History
2773:: CS1 maint: bot: original URL status unknown (
2734:"Emergent Biosolutions – Board of Directors bio"
2006:GEN - Genetic Engineering and Biotechnology News
1898:
1181:
371:Federally Funded Research and Development Center
3423:Cancer organizations based in the United States
2861:"Monica Bertagnolli becomes NCI director - NCI"
3129:National Institute of General Medical Sciences
2092:
2090:
395:American Recovery and Reinvestment Act of 2009
3200:National Institutes of Health Clinical Center
3018:
2791:. National Cancer Institute. 18 December 2018
2684:
2467:"About NCI Division of Extramural Activities"
2113:JNCI Journal of the National Cancer Institute
1886:. National Cancer Institute. 18 December 2018
3216:Advanced Research Projects Agency for Health
2067:
2065:
1061:falling under the aegis of the DCB include:
1033:Division of Cancer Epidemiology and Genetics
237:The NCI supports a nationwide network of 72
193:U.S. Department of Health and Human Services
2610:. National Cancer Institute. 26 August 2015
2532:"History of the NCI Cancer Centers Program"
2087:
1999:
1143:Center for Strategic Scientific Initiatives
3025:
3011:
2949:
1669:, Principal Deputy Director, 2002 to 2004.
1157:Center to Reduce Cancer Health Disparities
1078:Division of Cancer Treatment and Diagnosis
295:made the NCI an operating division of the
160:
3064:National Heart, Lung, and Blood Institute
2213:
2075:. National Cancer Institute. 5 April 2012
2062:
1274:prototype compounds in the NCI database.
1110:
3448:1937 establishments in the United States
3069:National Human Genome Research Institute
2931:Developmental Therapeutics Program (DTP)
2638:. National Cancer Institute. 12 May 2015
2594:
2100:. National Cancer Institute. 2014-05-29.
2098:"NCI's National Clinical Trials Network"
2058:. National Cancer Institute. 2018-12-20.
2026:"NCI-Frederick: NCI-Frederick Home Page"
2002:"Top 50 NIH-Funded Institutions of 2020"
1954:NCI's Shady Grove Campus To Open In 2013
1923:
1831:Journal of the National Cancer Institute
809:Cis-diamminedichloroplatinum (Cisplatin)
735:
582:
439:
285:Journal of the National Cancer Institute
261:
253:
3438:Medical research institutes in Maryland
2622:
2566:
2332:
2177:
1933:. National Cancer Institute. 1980-01-01
1848:
1163:Coordinating Center for Clinical Trials
61:Federal government of the United States
3410:
3377:National Center for Research Resources
3149:National Institute of Nursing Research
2836:"NCI Director Dr. Norman E. Sharpless"
2746:
2602:"Discovery & Development Services"
2299:
2147:
1653:
3006:
2906:
1837:National Comprehensive Cancer Network
3382:National Institutes of Health Police
3362:National Institutes of Health campus
3180:John E. Fogarty International Center
2104:
1624:October 17, 2022 – November 9, 2023
1352:Surgeon General of the United States
1234:NCI-60 Human Tumor Cell Lines Screen
1224:NCI-60 human cancer cell line screen
369:opened in Frederick, Maryland, as a
3387:Office of Laboratory Animal Welfare
3352:United States Public Health Service
3226:National Diabetes Education Program
3134:National Institute of Mental Health
1854:
1504:August 1, 1995 – September 30, 2001
16:American governmental health agency
13:
2635:Developmental Therapeutics Program
2607:Developmental Therapeutics Program
2579:Developmental Therapeutics Program
1548:September 15, 2006 – July 12, 2010
1226:and the Molecular Target Program.
1214:Developmental Therapeutics Program
1063:Physical Sciences-Oncology Network
14:
3464:
3453:Organizations established in 1937
3170:Center for Information Technology
2936:
2925:"THE NATIONAL CANCER ACT OF 1971"
2685:U.S. Congress (7 December 2006).
2658:"National Cancer Institute (NCI)"
1770:
1600:October 17, 2017 – April 30, 2022
1485:December 22, 1988 – April 1, 1995
1447:July 29, 1977 – December 31, 1980
1097:Division of Extramural Activities
204:institutes and centers of the NIH
3119:National Institute on Drug Abuse
2514:"OCC Homepage – OCCWebApp 2.1.0"
2000:Philippidis, Alex (2020-09-21).
1632:
1612:
1588:
1560:
1536:
1524:January 22, 2002 – June 10, 2006
1512:
1492:
1473:
1466:July 9, 1980 – September 1, 1988
1454:
1435:
1416:
1397:
1390:July 1, 1960 – November 10, 1969
1378:
1359:
1335:
1318:
1311:January 13, 1938 – July 31, 1943
1299:
1198:National Clinical Trials Network
1130:and cancer genomics initiatives.
25:
3357:Division of Intramural Research
2986:Important Events in NCI History
2878:
2853:
2828:
2803:
2781:
2726:
2664:
2650:
2542:
2524:
2506:
2477:
2459:
2441:
2423:
2405:
2387:
2373:
2355:
2326:
2293:
2249:
2073:"NCI-Designated Cancer Centers"
1177:Informatics for Consumer Health
1002:
431:Anti-cancer drug investigations
20:National Cancer Institute (NCI)
2185:"75th Congress Public Law 244"
2048:
2018:
1993:
1957:. Vol. LXII. 2 April 2010
1807:American Cancer Society Center
1605:Commissioner of Food and Drugs
1572:July 12, 2010 – March 31, 2015
1529:Commissioner of Food and Drugs
1428:May 5, 1972 – November 1, 1976
1330:August 1, 1943 – July 1, 1947
424:Commissioner of Food and Drugs
377:NIH Revitalization Act of 1993
72:31 Center Drive, Building 31,
1:
3428:National Institutes of Health
3418:Cancer research organizations
3400:indicate acting officeholders
3035:National Institutes of Health
2300:Kaplan, Sheila (2019-03-12).
2119:(2): 133–137. 1 August 1957.
1581:National Institutes of Health
1277:
1188:NCI-designated Cancer Centers
1182:NCI-designated Cancer Centers
1075:Division of Cancer Prevention
1047:
1010:
303:. Congress later amended the
297:National Institutes of Health
282:1940: The first issue of the
239:NCI-designated Cancer Centers
230:. The NCI receives more than
189:National Institutes of Health
118:National Institutes of Health
3175:Center for Scientific Review
3154:National Library of Medicine
2431:"Division of Cancer Biology"
1842:NCI-designated Cancer Center
1644:December 18, 2023 – Present
1347:July 1, 1947 – April 6, 1948
1160:Center for Research Strategy
212:intramural research programs
7:
3443:75th United States Congress
3074:National Institute on Aging
2697:(134): S11404–29, S11447–51
2582:. National Cancer Institute
1864:. National Cancer Institute
1799:
1409:July 13, 1970 – May 5, 1972
1371:May 15, 1948 – July 1, 1960
1170:
360:National Cancer Act of 1971
309:National Cancer Act of 1971
249:
10:
3469:
1818:Cancer Information Service
1661:Amy Berrington de González
1424:Frank Joseph Rauscher, Jr.
1174:
1166:Technology Transfer Center
1137:Center for Cancer Training
1119:Center for Cancer Genomics
1053:Division of Cancer Biology
1017:Center for Cancer Research
386:to study pseudoscientific
332:-supported cancer centers.
271:August 5, 1937: President
244:
134:NCI at NIH Bethesda Campus
3395:
3337:
3239:
3208:
3162:
3054:National Cancer Institute
3046:
2913:National Cancer Institute
2840:National Cancer Institute
2536:National Cancer Institute
2435:National Cancer Institute
2417:National Cancer Institute
2367:National Cancer Institute
1793:Radio-Genomics Consortium
305:Public Health Service Act
301:Public Health Service Act
181:National Cancer Institute
173:
168:
147:
123:
113:
103:
86:
66:
56:
38:
33:
24:
3372:NIH Public Access Policy
2550:"NCTN Biospecimen Banks"
2518:cancercenters.cancer.gov
2413:"DCB Research Portfolio"
1520:Andrew C. von Eschenbach
1140:Center for Global Health
328:1960: NCI began funding
317:1957: The first cancer,
3433:National Cancer Centers
3284:James Augustine Shannon
3195:Vaccine Research Center
2919:"NCI MISSION STATEMENT"
2915:Retrieved 11 June 2010.
1128:The Cancer Genome Atlas
855:All-trans retinoid acid
70:Office of the Director,
3279:William H. Sebrell, Jr
3059:National Eye Institute
1759:, senior investigator.
1647:17th Director of NCI.
1462:Vincent T. DeVita, Jr.
1350:Served as the seventh
1343:Leonard Andrew Scheele
1111:Office of the director
743:
590:
447:
413:21st Century Cures Act
382:1998: Establishes the
299:by its passage of the
293:United States Congress
267:
259:
234:in funding each year.
130:NCI Shady Grove Campus
44:; 87 years ago
3299:Donald S. Fredrickson
3221:Visible Human Project
2221:"Statute 50 Page 559"
2125:10.1093/jnci/19.2.133
1931:"Visitor Information"
1443:Arthur Canfield Upton
1386:Kenneth Milo Endicott
1175:Further information:
739:
586:
557:Fludarabine phosphate
443:
418:On October 17, 2017,
390:treatments for cancer
277:Public Health Service
273:Franklin D. Roosevelt
265:
257:
2995:Major NCI Milestones
2691:Congressional Record
2554:nctnbanks.cancer.gov
2336:(November 1, 2019).
1849:Notes and references
1367:John Roderick Heller
569:Chlorodeoxyadenosine
537:Cytosine arabinoside
388:alternative medicine
139:NCI Frederick Campus
3304:James B. Wyngaarden
2687:"Executive Session"
2630:"Molecular Targets"
2471:deainfo.nci.nih.gov
2449:"About DCTD – DCTD"
1654:Notable NCI faculty
1596:Norman E. Sharpless
1583:from 1993 to 1999.
1544:John E. Niederhuber
1500:Richard D. Klausner
1354:from 1948 to 1956.
928:Methyl prednisolone
228:Frederick, Maryland
42:August 5, 1937
21:
3329:Monica Bertagnolli
2907:General references
2363:"NCI Organization"
2306:The New York Times
2036:on 16 October 2012
1795:(established 2009)
1757:Xiaohong Rose Yang
1715:Rosandra N. Kaplan
1620:Monica Bertagnolli
1326:Roscoe Roy Spencer
1245:60 cell line assay
1204:precision medicine
845:Hexamethylmelamine
744:
591:
448:
345:biological warfare
268:
260:
216:Bethesda, Maryland
19:
3405:
3404:
3289:Robert Q. Marston
3269:Lewis R. Thompson
3254:Milton J. Rosenau
3249:Joseph J. Kinyoun
2261:. 18 October 2017
1862:"Director's Page"
1783:Sudhir Srivastava
1705:Michael Gottesman
1651:
1650:
1575:Co-winner of the
437:Alkylating agents
408:from that amount.
321:, was cured with
177:
176:
104:Parent department
3460:
3314:Harold E. Varmus
3259:John F. Anderson
3231:BRAIN Initiative
3027:
3020:
3013:
3004:
3003:
2966:NCI Dictionaries
2953:
2948:
2947:
2945:Official website
2901:
2900:
2898:
2897:
2882:
2876:
2875:
2873:
2872:
2857:
2851:
2850:
2848:
2847:
2832:
2826:
2825:
2823:
2821:
2807:
2801:
2800:
2798:
2796:
2785:
2779:
2778:
2772:
2764:
2762:
2761:
2750:
2744:
2743:
2741:
2740:
2730:
2724:
2723:
2712:
2706:
2705:
2703:
2702:
2682:
2676:
2675:
2668:
2662:
2661:
2654:
2648:
2647:
2645:
2643:
2626:
2620:
2619:
2617:
2615:
2598:
2592:
2591:
2589:
2587:
2570:
2564:
2563:
2561:
2560:
2546:
2540:
2539:
2528:
2522:
2521:
2510:
2504:
2503:
2501:
2500:
2491:. Archived from
2481:
2475:
2474:
2463:
2457:
2456:
2445:
2439:
2438:
2427:
2421:
2420:
2409:
2403:
2402:
2391:
2385:
2384:
2377:
2371:
2370:
2359:
2353:
2352:
2350:
2348:
2342:The NIH Director
2334:Collins, Francis
2330:
2324:
2323:
2321:
2320:
2297:
2291:
2290:
2284:
2280:
2278:
2270:
2268:
2266:
2253:
2247:
2246:
2244:
2242:
2237:on 17 March 2016
2236:
2230:. Archived from
2225:
2217:
2211:
2210:
2208:
2206:
2200:
2194:. Archived from
2189:
2181:
2175:
2174:
2172:
2170:
2161:. Archived from
2151:
2145:
2144:
2108:
2102:
2101:
2094:
2085:
2084:
2082:
2080:
2069:
2060:
2059:
2056:"Funding Trends"
2052:
2046:
2045:
2043:
2041:
2032:. Archived from
2022:
2016:
2015:
2013:
2012:
1997:
1991:
1990:
1984:
1980:
1978:
1970:
1964:
1962:
1949:
1943:
1942:
1940:
1938:
1927:
1921:
1920:
1918:
1916:
1902:
1896:
1895:
1893:
1891:
1880:
1874:
1873:
1871:
1869:
1858:
1779:, senior adviser
1746:Steven Rosenberg
1731:Charles J. Sherr
1673:Michael B. Sporn
1636:
1616:
1592:
1564:
1540:
1516:
1496:
1477:
1458:
1439:
1420:
1401:
1382:
1363:
1339:
1322:
1303:
1282:
1281:
1243:screen with the
462:Cyclophosphamide
445:Cyclophosphamide
420:Norman Sharpless
407:
403:
335:1971: President
233:
164:
159:
156:
154:
87:Agency executive
52:
50:
45:
29:
22:
18:
3468:
3467:
3463:
3462:
3461:
3459:
3458:
3457:
3408:
3407:
3406:
3401:
3391:
3333:
3324:Francis Collins
3309:Bernadine Healy
3264:George W. McCoy
3235:
3204:
3158:
3042:
3031:
2970:clinical trials
2961:USAspending.gov
2943:
2942:
2939:
2909:
2904:
2895:
2893:
2884:
2883:
2879:
2870:
2868:
2859:
2858:
2854:
2845:
2843:
2834:
2833:
2829:
2819:
2817:
2809:
2808:
2804:
2794:
2792:
2787:
2786:
2782:
2766:
2765:
2759:
2757:
2752:
2751:
2747:
2738:
2736:
2732:
2731:
2727:
2714:
2713:
2709:
2700:
2698:
2683:
2679:
2670:
2669:
2665:
2656:
2655:
2651:
2641:
2639:
2628:
2627:
2623:
2613:
2611:
2600:
2599:
2595:
2585:
2583:
2572:
2571:
2567:
2558:
2556:
2548:
2547:
2543:
2530:
2529:
2525:
2512:
2511:
2507:
2498:
2496:
2489:cssi.cancer.gov
2483:
2482:
2478:
2465:
2464:
2460:
2453:dctd.cancer.gov
2447:
2446:
2442:
2429:
2428:
2424:
2411:
2410:
2406:
2393:
2392:
2388:
2383:. 21 July 2014.
2379:
2378:
2374:
2361:
2360:
2356:
2346:
2344:
2331:
2327:
2318:
2316:
2298:
2294:
2282:
2281:
2272:
2271:
2264:
2262:
2255:
2254:
2250:
2240:
2238:
2234:
2223:
2219:
2218:
2214:
2204:
2202:
2201:on 7 March 2016
2198:
2187:
2183:
2182:
2178:
2168:
2166:
2165:on 6 March 2016
2153:
2152:
2148:
2110:
2109:
2105:
2096:
2095:
2088:
2078:
2076:
2071:
2070:
2063:
2054:
2053:
2049:
2039:
2037:
2024:
2023:
2019:
2010:
2008:
1998:
1994:
1982:
1981:
1972:
1971:
1960:
1958:
1951:
1950:
1946:
1936:
1934:
1929:
1928:
1924:
1914:
1912:
1904:
1903:
1899:
1889:
1887:
1882:
1881:
1877:
1867:
1865:
1860:
1859:
1855:
1851:
1846:
1802:
1773:
1768:
1763:Douglas R. Lowy
1736:Louis M. Staudt
1710:Robert C. Gallo
1685:Susan Gottesman
1656:
1640:Kimryn Rathmell
1405:Carl Gwin Baker
1280:
1251:examination of
1236:
1216:
1200:
1184:
1179:
1173:
1113:
1050:
1013:
1005:
1000:
999:
898:Fluoxymesterone
865:Porfimer sodium
728:
727:
513:Antimetabolites
433:
406:US$ 1.3 billion
405:
398:
319:choriocarcinoma
252:
247:
231:
151:
143:
99:
94:Kimryn Rathmell
81:
71:
48:
46:
43:
34:Agency overview
17:
12:
11:
5:
3466:
3456:
3455:
3450:
3445:
3440:
3435:
3430:
3425:
3420:
3403:
3402:
3396:
3393:
3392:
3390:
3389:
3384:
3379:
3374:
3369:
3364:
3359:
3354:
3349:
3341:
3339:
3335:
3334:
3332:
3331:
3326:
3321:
3319:Elias Zerhouni
3316:
3311:
3306:
3301:
3296:
3291:
3286:
3281:
3276:
3271:
3266:
3261:
3256:
3251:
3245:
3243:
3237:
3236:
3234:
3233:
3228:
3223:
3218:
3212:
3210:
3206:
3205:
3203:
3202:
3197:
3192:
3187:
3182:
3177:
3172:
3166:
3164:
3160:
3159:
3157:
3156:
3151:
3146:
3141:
3136:
3131:
3126:
3121:
3116:
3111:
3106:
3101:
3096:
3091:
3086:
3081:
3076:
3071:
3066:
3061:
3056:
3050:
3048:
3044:
3043:
3030:
3029:
3022:
3015:
3007:
3001:
3000:
2992:
2983:
2973:
2963:
2954:
2938:
2937:External links
2935:
2934:
2933:
2928:
2922:
2916:
2908:
2905:
2903:
2902:
2890:www.cancer.gov
2877:
2865:www.cancer.gov
2852:
2827:
2802:
2780:
2745:
2725:
2720:www.senate.gov
2707:
2677:
2663:
2660:. 7 July 2015.
2649:
2621:
2593:
2565:
2541:
2523:
2505:
2476:
2458:
2440:
2422:
2404:
2386:
2372:
2354:
2325:
2292:
2248:
2228:LegisWorks.org
2212:
2192:LegisWorks.org
2176:
2159:LegisWorks.org
2146:
2103:
2086:
2061:
2047:
2017:
1992:
1944:
1922:
1897:
1875:
1852:
1850:
1847:
1845:
1844:
1839:
1834:
1827:
1821:
1815:
1809:
1803:
1801:
1798:
1797:
1796:
1789:Catharine West
1786:
1780:
1772:
1771:Notable people
1769:
1767:
1766:
1760:
1754:
1748:
1743:
1738:
1733:
1728:
1723:
1721:Michael Potter
1718:
1712:
1707:
1702:
1697:
1692:
1687:
1682:
1676:
1670:
1664:
1657:
1655:
1652:
1649:
1648:
1645:
1642:
1637:
1629:
1628:
1625:
1622:
1617:
1609:
1608:
1601:
1598:
1593:
1585:
1584:
1573:
1570:
1565:
1557:
1556:
1553:George W. Bush
1549:
1546:
1541:
1533:
1532:
1525:
1522:
1517:
1509:
1508:
1505:
1502:
1497:
1489:
1488:
1486:
1483:
1478:
1470:
1469:
1467:
1464:
1459:
1451:
1450:
1448:
1445:
1440:
1432:
1431:
1429:
1426:
1421:
1413:
1412:
1410:
1407:
1402:
1394:
1393:
1391:
1388:
1383:
1375:
1374:
1372:
1369:
1364:
1356:
1355:
1348:
1345:
1340:
1332:
1331:
1328:
1323:
1315:
1314:
1312:
1309:
1304:
1296:
1295:
1292:
1289:
1286:
1279:
1276:
1235:
1232:
1215:
1212:
1199:
1196:
1183:
1180:
1172:
1169:
1168:
1167:
1164:
1161:
1158:
1154:
1153:
1152:
1151:
1145:
1144:
1141:
1138:
1134:
1133:
1132:
1131:
1121:
1120:
1117:
1112:
1109:
1108:
1107:
1106:
1105:
1099:
1098:
1094:
1093:
1092:
1091:
1080:
1079:
1076:
1073:
1069:
1068:
1067:
1066:
1055:
1054:
1049:
1046:
1045:
1044:
1043:
1042:
1036:
1035:
1029:
1028:
1027:
1026:
1020:
1019:
1012:
1009:
1004:
1001:
998:
997:
987:
981:
975:
961:
942:
941:
935:
930:
925:
915:
908:Dromostanolone
905:
895:
889:
873:
872:
862:
852:
842:
832:
822:
812:
806:
796:
786:
776:
765:
755:
730:
729:
726:
725:
703:
702:
692:
682:
672:
662:
655:L-Asparaginase
652:
642:
632:
622:
612:
602:
573:
572:
566:
560:
554:
544:
534:
528:
522:
519:Mercaptopurine
510:
509:
499:
492:Streptozotocin
489:
475:
469:
459:
435:
434:
432:
429:
428:
427:
416:
409:
391:
380:
373:
363:
356:
347:facilities at
339:converted the
333:
326:
315:
312:
289:
288:was published.
280:
251:
248:
246:
243:
175:
174:
171:
170:
166:
165:
149:
145:
144:
142:
141:
136:
131:
127:
125:
124:Child agencies
121:
120:
115:
111:
110:
105:
101:
100:
98:
97:
90:
88:
84:
83:
68:
64:
63:
58:
54:
53:
40:
36:
35:
31:
30:
15:
9:
6:
4:
3:
2:
3465:
3454:
3451:
3449:
3446:
3444:
3441:
3439:
3436:
3434:
3431:
3429:
3426:
3424:
3421:
3419:
3416:
3415:
3413:
3399:
3394:
3388:
3385:
3383:
3380:
3378:
3375:
3373:
3370:
3368:
3365:
3363:
3360:
3358:
3355:
3353:
3350:
3348:
3347:
3343:
3342:
3340:
3336:
3330:
3327:
3325:
3322:
3320:
3317:
3315:
3312:
3310:
3307:
3305:
3302:
3300:
3297:
3295:
3292:
3290:
3287:
3285:
3282:
3280:
3277:
3275:
3272:
3270:
3267:
3265:
3262:
3260:
3257:
3255:
3252:
3250:
3247:
3246:
3244:
3242:
3238:
3232:
3229:
3227:
3224:
3222:
3219:
3217:
3214:
3213:
3211:
3207:
3201:
3198:
3196:
3193:
3191:
3188:
3186:
3183:
3181:
3178:
3176:
3173:
3171:
3168:
3167:
3165:
3161:
3155:
3152:
3150:
3147:
3145:
3142:
3140:
3137:
3135:
3132:
3130:
3127:
3125:
3122:
3120:
3117:
3115:
3112:
3110:
3107:
3105:
3102:
3100:
3097:
3095:
3092:
3090:
3087:
3085:
3082:
3080:
3077:
3075:
3072:
3070:
3067:
3065:
3062:
3060:
3057:
3055:
3052:
3051:
3049:
3045:
3040:
3036:
3028:
3023:
3021:
3016:
3014:
3009:
3008:
3005:
2999:
2996:
2993:
2991:
2987:
2984:
2981:
2977:
2974:
2971:
2967:
2964:
2962:
2958:
2955:
2952:
2946:
2941:
2940:
2932:
2929:
2926:
2923:
2920:
2917:
2914:
2911:
2910:
2891:
2887:
2881:
2866:
2862:
2856:
2841:
2837:
2831:
2816:
2812:
2806:
2790:
2784:
2776:
2770:
2755:
2749:
2735:
2729:
2721:
2717:
2711:
2696:
2692:
2688:
2681:
2673:
2667:
2659:
2653:
2637:
2636:
2631:
2625:
2609:
2608:
2603:
2597:
2581:
2580:
2575:
2569:
2555:
2551:
2545:
2538:. 2012-08-13.
2537:
2533:
2527:
2519:
2515:
2509:
2495:on 2017-09-29
2494:
2490:
2486:
2480:
2472:
2468:
2462:
2454:
2450:
2444:
2437:. 2016-08-08.
2436:
2432:
2426:
2419:. 2016-08-08.
2418:
2414:
2408:
2401:. 1980-01-01.
2400:
2396:
2390:
2382:
2376:
2369:. 1980-01-01.
2368:
2364:
2358:
2343:
2339:
2335:
2329:
2315:
2311:
2307:
2303:
2296:
2288:
2276:
2260:
2259:
2252:
2233:
2229:
2222:
2216:
2197:
2193:
2186:
2180:
2164:
2160:
2156:
2150:
2142:
2138:
2134:
2130:
2126:
2122:
2118:
2114:
2107:
2099:
2093:
2091:
2074:
2068:
2066:
2057:
2051:
2035:
2031:
2027:
2021:
2007:
2003:
1996:
1988:
1976:
1969:
1956:
1955:
1948:
1932:
1926:
1911:
1907:
1901:
1885:
1879:
1863:
1857:
1853:
1843:
1840:
1838:
1835:
1833:
1832:
1828:
1825:
1822:
1819:
1816:
1813:
1810:
1808:
1805:
1804:
1794:
1790:
1787:
1784:
1781:
1778:
1775:
1774:
1764:
1761:
1758:
1755:
1752:
1751:Alfred Singer
1749:
1747:
1744:
1742:
1741:Gordon Zubrod
1739:
1737:
1734:
1732:
1729:
1727:
1724:
1722:
1719:
1716:
1713:
1711:
1708:
1706:
1703:
1701:
1698:
1696:
1693:
1691:
1688:
1686:
1683:
1680:
1677:
1674:
1671:
1668:
1665:
1662:
1659:
1658:
1646:
1643:
1641:
1638:
1635:
1631:
1630:
1626:
1623:
1621:
1618:
1615:
1611:
1610:
1606:
1602:
1599:
1597:
1594:
1591:
1587:
1586:
1582:
1578:
1574:
1571:
1569:
1568:Harold Varmus
1566:
1563:
1559:
1558:
1554:
1550:
1547:
1545:
1542:
1539:
1535:
1534:
1530:
1526:
1523:
1521:
1518:
1515:
1511:
1510:
1506:
1503:
1501:
1498:
1495:
1491:
1490:
1487:
1484:
1482:
1481:Samuel Broder
1479:
1476:
1472:
1471:
1468:
1465:
1463:
1460:
1457:
1453:
1452:
1449:
1446:
1444:
1441:
1438:
1434:
1433:
1430:
1427:
1425:
1422:
1419:
1415:
1414:
1411:
1408:
1406:
1403:
1400:
1396:
1395:
1392:
1389:
1387:
1384:
1381:
1377:
1376:
1373:
1370:
1368:
1365:
1362:
1358:
1357:
1353:
1349:
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3294:Robert Stone
3053:
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2979:
2894:. Retrieved
2892:. 2023-12-18
2889:
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2869:. Retrieved
2867:. 2022-10-03
2864:
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1925:
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1909:
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1878:
1866:. Retrieved
1856:
1829:
1792:
1777:Susan Shurin
1726:Sandra Wolin
1700:Elaine Jaffe
1690:Sankar Adhya
1667:Kathryn Zoon
1272:
1261:
1259:evaluation.
1241:cytotoxicity
1237:
1228:
1221:
1217:
1208:
1201:
1193:
1185:
1006:
1003:Organization
944:Biologicals
943:
933:Prednisolone
918:Testolactone
874:
815:Mitoxantrone
758:Procarbazine
704:
525:Methotrexate
511:
452:Chlorambucil
349:Fort Detrick
323:chemotherapy
283:
236:
224:Fort Detrick
201:
184:
180:
178:
67:Headquarters
57:Jurisdiction
2998:infographic
2990:NIH Almanac
2959:account on
2815:NED.NIH.gov
2395:"DCEG Home"
2381:"About CCR"
2347:December 3,
2283:|work=
2040:18 December
2030:NCIfCrf.gov
1983:|work=
1910:NED.NIH.gov
1679:Tom Misteli
1577:Nobel Prize
825:Carboplatin
779:Dacarbazine
767:O, P'-DDD (
748:Hydroxyurea
741:Carboplatin
645:Mitomycin C
635:Doxorubicin
615:Mithramycin
595:Vincristine
588:Vincristine
580:antibiotics
563:Pentostatin
547:Floxuridine
531:Thioguanine
341:U.S. Army's
3412:Categories
3346:NIH Record
3274:Rolla Dyer
3047:Institutes
2896:2023-12-26
2871:2022-10-21
2846:2020-02-12
2760:2015-04-02
2739:2013-12-06
2701:2006-12-12
2559:2024-01-22
2499:2017-09-28
2319:2019-12-04
2011:2021-04-25
1695:Ira Pastan
1278:Leadership
1048:Extramural
1011:Intramural
950:interferon
902:Halotestin
892:Prednisone
835:Levamisole
829:Paraplatin
819:Novantrone
803:Carmustine
722:naringenin
707:flavonoids
699:Paclitaxel
689:Teniposide
669:Cerubidine
665:Daunomycin
639:Adriamycin
502:Ifosfamide
484:) (1959) (
411:2016: The
402:10 billion
393:2009: The
375:1993: The
365:1975: The
358:1971: The
330:government
291:1944: The
96:, Director
49:1937-08-05
3241:Directors
2988:from the
2820:2 January
2795:1 January
2642:7 January
2614:6 January
2586:6 January
2314:0362-4331
2285:ignored (
2275:cite book
2265:1 January
2241:1 January
2205:1 January
2169:1 January
2133:0027-8874
1985:ignored (
1975:cite book
1961:2 January
1937:2 January
1915:2 January
1890:1 January
1257:xenograft
994:Proleukin
958:Roferon-A
869:Photofrin
839:Ergamisol
793:Lomustine
732:Synthetic
716:quercetin
679:Etoposide
675:VP-16-213
649:Mutamycin
629:Blenoxane
625:Bleomycin
619:Mithracin
576:alkaloids
478:Melphalan
397:provided
307:with the
169:Footnotes
3209:Programs
2769:cite web
2141:13502712
2079:July 26,
1800:See also
1288:Director
1285:Portrait
1270:target.
1264:in vitro
1171:Programs
996:) (1992)
974:) (1990)
968:TheraCys
960:) (1986)
954:Intron A
924:) (1970)
914:) (1961)
904:) (1958)
880:steroids
876:Hormones
871:) (1995)
861:) (1995)
859:Vesanoid
851:) (1990)
841:) (1990)
831:) (1989)
821:) (1988)
805:) (1977)
795:) (1976)
785:) (1975)
775:) (1970)
773:Mitotane
769:Lysodren
764:) (1969)
762:Matulane
754:) (1967)
719:galangin
701:) (1992)
691:) (1992)
681:) (1983)
671:) (1979)
661:) (1978)
651:) (1974)
641:) (1974)
631:) (1973)
621:) (1970)
611:) (1964)
609:Cosmegen
601:) (1963)
553:) (1970)
543:) (1969)
508:) (1988)
498:) (1982)
488:in 1993)
472:Thiotepa
468:) (1959)
458:) (1957)
456:Leukeran
353:Maryland
250:Timeline
78:Maryland
74:Bethesda
3398:Italics
3338:Related
3163:Centers
1868:1 April
1826:(EORTC)
1249:in vivo
938:Zoladex
912:Drolban
849:Hexalen
713:chrysin
599:Oncovin
496:Zanosar
482:Alkeran
466:Cytoxan
343:former
325:at NCI.
245:History
155:.cancer
148:Website
47: (
2312:
2139:
2131:
1294:Notes
1291:Tenure
986:(1991)
984:GM-CSF
980:(1991)
948:Alpha
940:(1989)
922:Teslac
894:(1953)
888:(1950)
811:(1978)
752:Hydrea
734:drugs
724:(1994)
705:Plant
659:Elspar
574:Plant
571:(1992)
565:(1991)
559:(1991)
533:(1966)
527:(1953)
521:(1953)
474:(1959)
208:grants
197:cancer
39:Formed
3033:U.S.
2235:(PDF)
2224:(PDF)
2199:(PDF)
2188:(PDF)
1820:(CIS)
1812:caBIG
1253:tumor
978:G-CSF
695:Taxol
685:VM-26
541:Ara-C
82:20814
3039:list
2822:2019
2797:2019
2775:link
2644:2018
2616:2018
2588:2018
2349:2019
2310:ISSN
2287:help
2267:2019
2243:2019
2207:2019
2171:2019
2137:PMID
2129:ISSN
2081:2019
2042:2011
1987:help
1963:2019
1939:2019
1917:2019
1892:2019
1870:2015
1186:The
972:TICE
878:and
799:BCNU
789:CCNU
783:DTIC
578:and
551:FUDR
506:Ifex
400:US$
179:The
157:.gov
2978:in
2976:NCI
2957:NCI
2695:152
2121:doi
964:BCG
886:DES
226:in
222:at
214:in
185:NCI
153:www
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