348:
34:
in children constitute a group of rare disorders that are characterised by tissue hypertrophy. Individual overgrowth syndromes have been shown to overlap with regard to clinical and radiologic features. The details of the genetic bases of these syndromes are unfolding. Any of the three embryonic
35:
tissue layers may be involved. The syndromes may manifest in localized or generalized tissue overgrowth. Latitudinal and longitudinal growth may be affected. Nevertheless, the musculoskeletal features are central to the diagnosis of some syndromes such as
295:
50:
usually present in the postnatal period, characteristically between the second and third year of life. In general, children with overgrowth syndromes are at increased risk of embryonic tumor development.
352:
42:
The time of presentation of children with overgrowth syndromes is an important contributor to the differential diagnosis. Children with some overgrowth syndromes such as
391:
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640:
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98:
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83:
542:
240:"Differential diagnoses of overgrowth syndromes: The most important clinical and radiological disease manifestations"
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43:
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325:
861:
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150:
846:
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can be readily detectable at birth. In contrast, other overgrowth syndromes such as
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93:
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192:"Orthopaedic manifestations of Proteus syndrome in a child with literature update"
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Lacerda L da S, Alves ĂšD, Zanier JFC, Machado DC, Camilo GB, Lopes AJ (2014).
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Group of rare genetic disorders involving tissue hypertrophy
151:"Genetic syndromes associated with overgrowth in childhood"
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entry in the public domain NCI Dictionary of Cancer Terms
399:
277:
838:
190:EL-Sobky TA, Elsayed SM, EL Mikkawy DME (2015).
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385:
234:
232:
186:
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59:Examples of overgrowth syndromes include:
839:
373:
84:Macrocephaly-capillary malformation
13:
14:
878:
641:Bannayan–Riley–Ruvalcaba syndrome
273:
351: This article incorporates
346:
448:Bonnet–Dechaume–Blanc syndrome
364:U.S. National Cancer Institute
143:
99:Simpson–Golabi–Behmel syndrome
1:
443:Sakati–Nyhan–Tisdale syndrome
136:
681:Tatton-Brown–Rahman syndrome
651:Benign symmetric lipomatosis
155:Ann Pediatr Endocrinol Metab
114:Tatton-Brown–Rahman syndrome
55:List of overgrowth syndromes
7:
771:Branchio-oto-renal syndrome
646:Beckwith–Wiedemann syndrome
124:
64:Beckwith–Wiedemann syndrome
10:
883:
743:Zimmermann–Laband syndrome
695:Laurence–Moon–Bardet–Biedl
656:Klippel–Trénaunay syndrome
606:Caudal regression syndrome
581:Klippel–Trénaunay syndrome
543:Smith–Lemli–Opitz syndrome
513:Cornelia de Lange syndrome
359:Dictionary of Cancer Terms
208:10.1016/j.bonr.2015.09.004
167:10.6065/apem.2013.18.3.101
79:Klippel–Trénaunay syndrome
44:Klippel–Trénaunay syndrome
715:
694:
631:
591:Rubinstein–Taybi syndrome
561:
488:
408:
311:
281:
24:
661:Neurofibromatosis type I
548:Snyder–Robinson syndrome
498:1q21.1 deletion syndrome
438:Saethre–Chotzen syndrome
571:Adducted thumb syndrome
533:Silver–Russell syndrome
707:Laurence–Moon syndrome
503:Aarskog–Scott syndrome
458:Baller–Gerold syndrome
401:Congenital abnormality
353:public domain material
702:Bardet–Biedl syndrome
586:Nail–patella syndrome
478:Pierre Robin sequence
418:Acrocephalosyndactyly
109:Sturge–Weber syndrome
633:Overgrowth syndromes
32:Overgrowth syndromes
621:VACTERL association
340:Overgrowth syndrome
256:10.1155/2014/947451
25:Overgrowth syndrome
862:Neuroendocrinology
576:Holt–Oram syndrome
468:Goldenhar syndrome
428:Carpenter syndrome
312:External resources
74:Fragile X syndrome
834:
833:
731:Feingold syndrome
518:Dubowitz syndrome
508:Cockayne syndrome
433:Pfeiffer syndrome
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334:
89:Neurofibromatosis
29:
28:
19:Medical condition
874:
847:Growth disorders
815:Donohue syndrome
791:Timothy syndrome
671:Proteus syndrome
666:Perlman syndrome
528:Robinow syndrome
473:Moebius syndrome
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244:Radiol Res Pract
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94:Proteus syndrome
48:Proteus syndrome
37:Proteus syndrome
22:
21:
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852:Growth hormones
837:
836:
835:
830:
803:Marfan syndrome
787:Keutel syndrome
775:CHARGE syndrome
759:Fraser syndrome
717:
716:Combined/other,
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686:Weaver syndrome
627:
557:
553:Turner syndrome
538:Seckel syndrome
523:Noonan syndrome
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119:Weaver syndrome
69:CLOVES syndrome
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20:
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12:
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5:
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824:Fryns syndrome
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676:Sotos syndrome
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423:Apert syndrome
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282:Classification
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274:External links
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149:Ko JM (2013).
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104:Sotos syndrome
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490:Short stature
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596:Gastrulation
410:Craniofacial
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161:(3):101-5.
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58:
41:
31:
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718:known locus
616:Sirenomelia
857:Human size
841:Categories
611:Ectromelia
202::104-108.
137:References
867:Syndromes
820:Multiple
403:syndromes
250::947451.
131:Gigantism
600:mesoderm
463:Cyclopia
321:Orphanet
224:28377973
196:Bone Rep
125:See also
303:: Q87.3
264:4070411
216:5365241
175:4027072
454:Other
262:
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173:
563:Limbs
355:from
326:93460
248:2014
220:PMID
296:ICD
260:PMC
252:doi
212:PMC
204:doi
171:PMC
163:doi
843::
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789:,
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602::
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231:^
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181:^
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288:D
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