1332:
20:
1243:
848:
939:
1112:
1148:
1217:
1180:
1239:
1012:
272:
Sligar SG, Makris TM, Denisov IG (2005). "Thirty years of microbial P450 monooxygenase research: peroxo-heme intermediates--the central bus station in heme oxygenase catalysis".
760:
209:(2). Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, The University of Pittsburgh School of Medicine: 583–650.
1102:
734:
995:
1170:
909:
1267:
867:
1373:
404:
887:
1070:
828:
405:"The Medicine Prize Committee unanimously decided that the Wolf Prize in Medicine for 1986 be awarded to Osamu Hayaishi"
1043:
443:
201:
SW, Ryter; J, Alam (April 2006). "Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications".
1082:
1028:
19:
818:
599:
794:
780:
727:
342:
Mason HS, Fowlks WK, Peterson E (1955). "Oxygen transfer and electron transport by the phenolase complex".
142:"for the discovery of the oxygenase enzymes and elucidation of their structure and biological importance."
1311:
1160:
833:
789:
775:
68:
902:
1366:
1306:
1257:
1229:
1197:
803:
700:
687:
674:
661:
648:
635:
622:
584:
262:
Hayaishi et al. (1955) Mechanism of the pyrocatechase reaction, J. Am. Chem. Soc. 77 (1955) 5450-5451
930:
751:
594:
548:
491:
56:
40:
1152:
943:
720:
496:
123:
1291:
1207:
956:
139:
101:
158:
Fetzner, Susanne; Steiner, Roberto A. (2010). "Cofactor-independent oxidases and oxygenases".
1402:
1087:
1060:
895:
517:
436:
712:
1359:
1202:
1165:
926:
917:
823:
813:
589:
8:
1397:
1188:
553:
951:
876:
838:
486:
183:
1097:
249:
67:
Most oxygenases contain either a metal, usually iron, or an organic cofactor, usually
985:
386:
324:
289:
218:
175:
187:
1392:
1347:
532:
527:
501:
429:
378:
351:
316:
281:
245:
210:
167:
236:
Bugg TDH (2003). "Dioxygenase enzymes: catalytic mechanisms and chemical models".
1075:
579:
563:
476:
104:, transfer one oxygen atom to the substrate, and reduce the other oxygen atom to
83:
1343:
1301:
1281:
1276:
918:
743:
617:
558:
382:
320:
285:
214:
135:
52:
171:
1386:
1331:
522:
481:
97:
1120:
1116:
770:
471:
390:
328:
293:
222:
179:
138:
from Japan and Howard S. Mason from the US. Hayaishi was awarded the 1986
695:
630:
466:
111:
355:
1252:
857:
114:, or oxygen transferases, incorporate both atoms of molecular oxygen (O
1221:
1184:
1128:
669:
643:
369:
Waterman MR (2005). "Professor Howard Mason and oxygen activation".
1000:
1296:
134:
Oxygenases were discovered in 1955 simultaneously by two groups,
126:, responsible for breaking down numerous chemicals in the body.
1339:
1138:
1133:
1092:
798:
784:
682:
452:
44:
32:
1285:
1020:
978:
971:
966:
961:
742:
656:
105:
36:
1065:
1053:
1048:
1038:
1033:
1016:
990:
79:
421:
78:
Oxygenases constitute a major intracellular source of
341:
271:
51:(as in air) to it. The oxygenases form a class of
23:Molecular structure of tryptophan 2,3-dioxygenase
1384:
157:
1367:
903:
728:
437:
307:Hayaishi O (2005). "An odyssey with oxygen".
122:Among the most common monooxygenases are the
368:
1374:
1360:
910:
896:
735:
721:
444:
430:
306:
75:, leading to its transfer to substrate.
235:
93:Two types of oxygenases are recognized:
18:
1385:
160:Applied Microbiology and Biotechnology
118:) into the product(s) of the reaction.
891:
716:
425:
1326:
1103:24-hydroxycholesterol 7α-hydroxylase
829:4-Hydroxyphenylpyruvate dioxygenase
200:
13:
71:. These cofactors interact with O
14:
1414:
1330:
1083:Cholesterol 7 alpha-hydroxylase
1029:Flavin-containing monooxygenase
397:
362:
335:
300:
265:
256:
229:
194:
151:
1:
819:Homogentisate 1,2-dioxygenase
371:Biochem. Biophys. Res. Commun
309:Biochem. Biophys. Res. Commun
274:Biochem. Biophys. Res. Commun
250:10.1016/S0040-4020(03)00944-X
145:
1346:. You can help Knowledge by
795:Arachidonate 15-lipoxygenase
781:Arachidonate 12-lipoxygenase
88:
62:
7:
1312:Deoxyhypusine monooxygenase
834:Indoleamine 2,3-dioxygenase
790:Arachidonate 8-lipoxygenase
776:Arachidonate 5-lipoxygenase
451:
10:
1419:
1325:
383:10.1016/j.bbrc.2005.08.120
321:10.1016/j.bbrc.2005.09.019
286:10.1016/j.bbrc.2005.08.094
215:10.1152/physrev.00011.2005
129:
1307:Ecdysone 20-monooxygenase
1266:
1258:Stearoyl-CoA desaturase-1
1238:
1230:Dopamine beta-hydroxylase
1216:
1198:Phenylalanine hydroxylase
1179:
1147:
1111:
1011:
938:
866:
847:
804:Linoleate 11-lipoxygenase
759:
608:
600:Michaelis–Menten kinetics
572:
541:
510:
459:
172:10.1007/s00253-010-2455-0
492:Diffusion-limited enzyme
124:cytochrome P450 oxidases
59:is EC 1.13 or EC 1.14.
47:from molecular oxygen O
1342:-related article is a
1292:Squalene monooxygenase
1208:Tryptophan hydroxylase
957:HIF prolyl-hydroxylase
140:Wolf Prize in Medicine
102:mixed function oxidase
24:
1088:Methane monooxygenase
1061:Nitric oxide synthase
763:: two atoms of oxygen
585:Eadie–Hofstee diagram
518:Allosteric regulation
22:
1203:Tyrosine hydroxylase
927:steroid hydroxylases
851:: one atom of oxygen
824:Cysteine dioxygenase
814:Catechol dioxygenase
595:Lineweaver–Burk plot
43:by transferring the
1153:iron–sulfur protein
356:10.1021/ja01615a088
952:Prolyl hydroxylase
877:Inositol oxygenase
858:Firefly luciferase
839:Chlorite dismutase
811:other dioxygenase:
554:Enzyme superfamily
487:Enzyme promiscuity
25:
1355:
1354:
1320:
1319:
986:Lysyl hydroxylase
885:
884:
710:
709:
407:. Wolf Foundation
350:(10): 2914–2915.
244:(36): 7075–7101.
1410:
1376:
1369:
1362:
1334:
1327:
912:
905:
898:
889:
888:
737:
730:
723:
714:
713:
590:Hanes–Woolf plot
533:Enzyme activator
528:Enzyme inhibitor
502:Enzyme catalysis
446:
439:
432:
423:
422:
417:
416:
414:
412:
401:
395:
394:
366:
360:
359:
344:J. Am. Chem. Soc
339:
333:
332:
304:
298:
297:
269:
263:
260:
254:
253:
233:
227:
226:
198:
192:
191:
155:
1418:
1417:
1413:
1412:
1411:
1409:
1408:
1407:
1383:
1382:
1381:
1380:
1323:
1321:
1316:
1270:- miscellaneous
1262:
1234:
1212:
1175:
1143:
1107:
1098:14α-demethylase
1007:
934:
919:Oxidoreductases
916:
886:
881:
862:
843:
755:
744:Oxidoreductases
741:
711:
706:
618:Oxidoreductases
604:
580:Enzyme kinetics
568:
564:List of enzymes
537:
506:
477:Catalytic triad
455:
450:
420:
410:
408:
403:
402:
398:
367:
363:
340:
336:
305:
301:
270:
266:
261:
257:
234:
230:
199:
195:
156:
152:
148:
132:
117:
91:
84:carbon monoxide
74:
65:
53:oxidoreductases
50:
17:
12:
11:
5:
1416:
1406:
1405:
1400:
1395:
1379:
1378:
1371:
1364:
1356:
1353:
1352:
1335:
1318:
1317:
1315:
1314:
1309:
1304:
1299:
1294:
1289:
1282:Heme oxygenase
1279:
1277:Cyclooxygenase
1273:
1271:
1264:
1263:
1261:
1260:
1255:
1249:
1247:
1236:
1235:
1233:
1232:
1226:
1224:
1214:
1213:
1211:
1210:
1205:
1200:
1194:
1192:
1177:
1176:
1174:
1173:
1168:
1163:
1157:
1155:
1145:
1144:
1142:
1141:
1136:
1131:
1125:
1123:
1109:
1108:
1106:
1105:
1100:
1095:
1090:
1085:
1080:
1079:
1078:
1073:
1068:
1058:
1057:
1056:
1051:
1046:
1041:
1036:
1025:
1023:
1009:
1008:
1006:
1005:
1004:
1003:
998:
988:
983:
982:
981:
976:
975:
974:
969:
964:
948:
946:
944:2-oxoglutarate
936:
935:
915:
914:
907:
900:
892:
883:
882:
880:
879:
873:
871:
864:
863:
861:
860:
854:
852:
845:
844:
842:
841:
836:
831:
826:
821:
816:
807:
806:
801:
792:
787:
778:
766:
764:
757:
756:
748:monooxygenases
740:
739:
732:
725:
717:
708:
707:
705:
704:
691:
678:
665:
652:
639:
626:
612:
610:
606:
605:
603:
602:
597:
592:
587:
582:
576:
574:
570:
569:
567:
566:
561:
556:
551:
545:
543:
542:Classification
539:
538:
536:
535:
530:
525:
520:
514:
512:
508:
507:
505:
504:
499:
494:
489:
484:
479:
474:
469:
463:
461:
457:
456:
449:
448:
441:
434:
426:
419:
418:
396:
361:
334:
299:
264:
255:
228:
193:
166:(3): 791–804.
149:
147:
144:
136:Osamu Hayaishi
131:
128:
120:
119:
115:
109:
98:Monooxygenases
90:
87:
72:
64:
61:
48:
15:
9:
6:
4:
3:
2:
1415:
1404:
1401:
1399:
1396:
1394:
1391:
1390:
1388:
1377:
1372:
1370:
1365:
1363:
1358:
1357:
1351:
1349:
1345:
1341:
1336:
1333:
1329:
1328:
1324:
1313:
1310:
1308:
1305:
1303:
1300:
1298:
1295:
1293:
1290:
1287:
1283:
1280:
1278:
1275:
1274:
1272:
1269:
1265:
1259:
1256:
1254:
1251:
1250:
1248:
1245:
1241:
1237:
1231:
1228:
1227:
1225:
1223:
1219:
1215:
1209:
1206:
1204:
1201:
1199:
1196:
1195:
1193:
1190:
1189:BH4 dependent
1186:
1182:
1178:
1172:
1169:
1167:
1164:
1162:
1159:
1158:
1156:
1154:
1150:
1146:
1140:
1137:
1135:
1132:
1130:
1127:
1126:
1124:
1122:
1118:
1114:
1110:
1104:
1101:
1099:
1096:
1094:
1091:
1089:
1086:
1084:
1081:
1077:
1074:
1072:
1069:
1067:
1064:
1063:
1062:
1059:
1055:
1052:
1050:
1047:
1045:
1042:
1040:
1037:
1035:
1032:
1031:
1030:
1027:
1026:
1024:
1022:
1018:
1014:
1010:
1002:
999:
997:
994:
993:
992:
989:
987:
984:
980:
977:
973:
970:
968:
965:
963:
960:
959:
958:
955:
954:
953:
950:
949:
947:
945:
941:
937:
932:
928:
924:
920:
913:
908:
906:
901:
899:
894:
893:
890:
878:
875:
874:
872:
869:
865:
859:
856:
855:
853:
850:
846:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
809:
808:
805:
802:
800:
796:
793:
791:
788:
786:
782:
779:
777:
774:
772:
768:
767:
765:
762:
758:
753:
749:
745:
738:
733:
731:
726:
724:
719:
718:
715:
702:
698:
697:
692:
689:
685:
684:
679:
676:
672:
671:
666:
663:
659:
658:
653:
650:
646:
645:
640:
637:
633:
632:
627:
624:
620:
619:
614:
613:
611:
607:
601:
598:
596:
593:
591:
588:
586:
583:
581:
578:
577:
575:
571:
565:
562:
560:
559:Enzyme family
557:
555:
552:
550:
547:
546:
544:
540:
534:
531:
529:
526:
524:
523:Cooperativity
521:
519:
516:
515:
513:
509:
503:
500:
498:
495:
493:
490:
488:
485:
483:
482:Oxyanion hole
480:
478:
475:
473:
470:
468:
465:
464:
462:
458:
454:
447:
442:
440:
435:
433:
428:
427:
424:
406:
400:
392:
388:
384:
380:
376:
372:
365:
357:
353:
349:
345:
338:
330:
326:
322:
318:
314:
310:
303:
295:
291:
287:
283:
280:(1): 346–54.
279:
275:
268:
259:
251:
247:
243:
239:
232:
224:
220:
216:
212:
208:
204:
197:
189:
185:
181:
177:
173:
169:
165:
161:
154:
150:
143:
141:
137:
127:
125:
113:
110:
107:
103:
99:
96:
95:
94:
86:
85:
81:
76:
70:
60:
58:
54:
46:
42:
38:
34:
30:
21:
1403:Enzyme stubs
1348:expanding it
1337:
1322:
1121:flavoprotein
925:, including
923:dioxygenases
922:
810:
771:lipoxygenase
769:
747:
696:Translocases
693:
680:
667:
654:
641:
631:Transferases
628:
615:
472:Binding site
409:. Retrieved
399:
374:
370:
364:
347:
343:
337:
312:
308:
302:
277:
273:
267:
258:
241:
237:
231:
206:
202:
196:
163:
159:
153:
133:
121:
112:Dioxygenases
92:
77:
66:
28:
26:
467:Active site
377:(1): 7–11.
238:Tetrahedron
203:Physiol Rev
1398:Oxygenases
1387:Categories
1253:Tyrosinase
1220:: reduced
1183:: reduced
1151:: reduced
1115:: reduced
670:Isomerases
644:Hydrolases
511:Regulation
315:(1): 2–6.
146:References
1222:ascorbate
1185:pteridine
549:EC number
89:Mechanism
63:Structure
57:EC number
41:substrate
29:oxygenase
573:Kinetics
497:Cofactor
460:Activity
391:16153596
329:16185652
294:16139790
223:16601269
188:25377247
180:20157809
55:; their
37:oxidizes
1393:Enzymes
1268:1.14.99
1246:: other
1240:1.14.18
1218:1.14.17
1181:1.14.16
1149:1.14.15
1113:1.14.14
1013:1.14.13
940:1.14.11
870:: other
868:1.13.99
849:1.13.12
761:1.13.11
683:Ligases
453:Enzymes
411:May 12,
130:History
31:is any
1340:enzyme
1117:flavin
996:ALKBH1
799:ALOX15
785:ALOX12
657:Lyases
389:
327:
292:
221:
186:
178:
69:flavin
45:oxygen
33:enzyme
16:Enzyme
1338:This
1286:HMOX1
1021:NADPH
979:P4HTM
972:EGLN3
967:EGLN2
962:EGLN1
933:1.14)
754:1.13)
609:Types
184:S2CID
106:water
100:, or
35:that
1344:stub
1302:21A2
1297:17A1
1171:11A1
1166:11B2
1161:11B1
1129:19A1
1076:NOS3
1071:NOS2
1066:NOS1
1054:FMO5
1049:FMO4
1044:FMO3
1039:FMO2
1034:FMO1
1017:NADH
991:AlkB
701:list
694:EC7
688:list
681:EC6
675:list
668:EC5
662:list
655:EC4
649:list
642:EC3
636:list
629:EC2
623:list
616:EC1
413:2014
387:PMID
325:PMID
290:PMID
219:PMID
176:PMID
82:and
80:iron
1139:2E1
1134:2D6
1119:or
1093:3A4
1019:or
1001:FTO
379:doi
375:338
352:doi
317:doi
313:338
282:doi
278:338
246:doi
211:doi
168:doi
27:An
1389::
1244:19
1015::
942::
931:EC
921::
752:EC
746::
385:.
373:.
348:77
346:.
323:.
311:.
288:.
276:.
242:59
240:.
217:.
207:86
205:.
182:.
174:.
164:86
162:.
39:a
1375:e
1368:t
1361:v
1350:.
1288:)
1284:(
1242:-
1191:)
1187:(
929:(
911:e
904:t
897:v
797:/
783:/
773::
750:(
736:e
729:t
722:v
703:)
699:(
690:)
686:(
677:)
673:(
664:)
660:(
651:)
647:(
638:)
634:(
625:)
621:(
445:e
438:t
431:v
415:.
393:.
381::
358:.
354::
331:.
319::
296:.
284::
252:.
248::
225:.
213::
190:.
170::
116:2
108:.
73:2
49:2
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
