503:, which can be released by red blood cell lysis during infection or inflammatory disease, in combination with specific components of infection or cellular damage. Deletion of NLRP12 protects against pathology in animal models of hemolytic disease, suggesting this could also act as a therapeutic target. Similarly, the NLRC5-PANoptosome, which also contains NLRP12, was identified as a response to
411:-mediated PANoptosis during SARS-CoV-2 infection, thereby limiting the efficacy of IFN treatment during infection and resulting in morbidity and mortality. This suggests that inhibiting ZBP1 may improve the therapeutic efficacy of IFN therapy during SARS-CoV-2 infection and possibly other inflammatory conditions where IFN-mediated cell death and pathology occur.
1051:
Karki, Rajendra; Sharma, Bhesh Raj; Tuladhar, Shraddha; Williams, Evan Peter; Zalduondo, Lillian; Samir, Parimal; Zheng, Min; Sundaram, Balamurugan; Banoth, Balaji; Malireddi, R. K. Subbarao; Schreiner, Patrick; Neale, Geoffrey; Vogel, Peter; Webby, Richard; Kanneganti, Thirumala-Devi (2021-01-07).
564:, along with complex-forming molecules such as caspases and RIPKs. These components activate various downstream cell death executioners and play a role in disease. Therefore, modulating the components of this pathway has potential for therapy. However, excessive activation of PANoptosis can lead to
3702:
Karki, Rajendra; Sharma, Bhesh Raj; Tuladhar, Shraddha; Williams, Evan Peter; Zalduondo, Lillian; Samir, Parimal; Zheng, Min; Sundaram, Balamurugan; Banoth, Balaji; Malireddi, R. K. Subbarao; Schreiner, Patrick; Neale, Geoffrey; Vogel, Peter; Webby, Richard; Jonsson, Colleen Beth (2021-01-07).
3998:
Karki, Rajendra; Sharma, Bhesh Raj; Tuladhar, Shraddha; Williams, Evan Peter; Zalduondo, Lillian; Samir, Parimal; Zheng, Min; Sundaram, Balamurugan; Banoth, Balaji; Malireddi, R.K. Subbarao; Schreiner, Patrick; Neale, Geoffrey; Vogel, Peter; Webby, Richard; Jonsson, Colleen Beth (2021-01-07).
2841:
Rodriguez, Diego A.; Quarato, Giovanni; Liedmann, Swantje; Tummers, Bart; Zhang, Ting; Guy, Cliff; Crawford, Jeremy Chase; Palacios, Gustavo; Pelletier, Stephane; Kalkavan, Halime; Shaw, Jeremy J. P.; Fitzgerald, Patrick; Chen, Mark J.; Balachandran, Siddharth; Green, Douglas R. (2022-10-11).
1109:
Karki, Rajendra; Lee, SangJoon; Mall, Raghvendra; Pandian, Nagakannan; Wang, Yaqiu; Sharma, Bhesh Raj; Malireddi, Rk
Subbarao; Yang, Dong; Trifkovic, Sanja; Steele, Jacob A.; Connelly, Jon P.; Vogel, Peter; Pruitt-Miller, Shondra M.; Webby, Richard; Kanneganti, Thirumala-Devi (2022-05-19).
1589:
Sundaram, Balamurugan; Pandian, Nagakannan; Kim, Hee Jin; Abdelaal, Hadia M.; Mall, Raghvendra; Indari, Omkar; Sarkar, Roman; Tweedell, Rebecca E.; Alonzo, Emily Q.; Klein, Jonathon; Pruett-Miller, Shondra M.; Vogel, Peter; Kanneganti, Thirumala-Devi (June 2024).
2512:
Christgen, Shelbi; Zheng, Min; Kesavardhana, Sannula; Karki, Rajendra; Malireddi, R. K. Subbarao; Banoth, Balaji; Place, David E.; Briard, Benoit; Sharma, Bhesh Raj; Tuladhar, Shraddha; Samir, Parimal; Burton, Amanda; Kanneganti, Thirumala-Devi (2020).
1336:
Christgen, Shelbi; Zheng, Min; Kesavardhana, Sannula; Karki, Rajendra; Malireddi, R. K. Subbarao; Banoth, Balaji; Place, David E.; Briard, Benoit; Sharma, Bhesh Raj; Tuladhar, Shraddha; Samir, Parimal; Burton, Amanda; Kanneganti, Thirumala-Devi (2020).
3817:
Karki, Rajendra; Sundaram, Balamurugan; Sharma, Bhesh Raj; Lee, SangJoon; Malireddi, R.K. Subbarao; Nguyen, Lam Nhat; Christgen, Shelbi; Zheng, Min; Wang, Yaqiu; Samir, Parimal; Neale, Geoffrey; Vogel, Peter; Kanneganti, Thirumala-Devi (2021-10-19).
535:
in a murine model of HS and infection reduces mortality; furthermore, deleting essential PANoptosis effectors upstream completely rescues the mice from mortality, thereby identifying NINJ1 and PANoptosis effectors as potential therapeutic targets.
386:
PANoptosis has also been implicated in inflammatory diseases, neurological diseases, and cancer. Additionally, activation of PANoptosis can clear infected cells for host defense, and it has shown preclinical promise as an anti-cancer strategy.
3875:
Han, Joo-Hui; Karki, Rajendra; Malireddi, R. K. Subbarao; Mall, Raghvendra; Sarkar, Roman; Sharma, Bhesh Raj; Klein, Jonathon; Berns, Harmut; Pisharath, Harshan; Pruett-Miller, Shondra M.; Bae, Sung-Jin; Kanneganti, Thirumala-Devi (2024-02-26).
2322:
Lukens, John R.; Gurung, Prajwal; Vogel, Peter; Johnson, Gordon R.; Carter, Robert A.; McGoldrick, Daniel J.; Bandi, Srinivasa Rao; Calabrese, Christopher R.; Vande Walle, Lieselotte; Lamkanfi, Mohamed; Kanneganti, Thirumala-Devi (2014-12-11).
1977:
Kayagaki, Nobuhiko; Warming, SΓΈren; Lamkanfi, Mohamed; Vande Walle, Lieselotte; Louie, Salina; Dong, Jennifer; Newton, Kim; Qu, Yan; Liu, Jinfeng; Heldens, Sherry; Zhang, Juan; Lee, Wyne P.; Roose-Girma, Merone; Dixit, Vishva M. (2011-10-16).
407:. For example, PANoptosis is important for host defense during influenza infection through the ZBP1-PANoptosome and during HSV1 infections through the AIM2-PANoptosome. Studies with beta-coronaviruses have shown that IFN can induce
3599:
Christgen, Shelbi; Zheng, Zhen; Kesavardhana, Sannula; Karki, Rajendra; Malireddi, R K Subbarao; Banoth, Balaji; Place, David E; Sharma, Bhesh Raj; Tuladhar, Shraddha; Samir, Parimal; Burton, Amanda; Kanneganti, Thirumala-Devi.
3023:
Karki, Rajendra; Sharma, Bhesh Raj; Lee, Ein; Banoth, Balaji; Malireddi, R. K. Subbarao; Samir, Parimal; Tuladhar, Shraddha; Mummareddy, Harisankeerth; Burton, Amanda R.; Vogel, Peter; Kanneganti, Thirumala-Devi (2020-06-18).
907:
Karki, Rajendra; Sharma, Bhesh Raj; Lee, Ein; Banoth, Balaji; Malireddi, R.K. Subbarao; Samir, Parimal; Tuladhar, Shraddha; Mummareddy, Harisankeerth; Burton, Amanda R.; Vogel, Peter; Kanneganti, Thirumala-Devi (2020-06-18).
1528:
Sundaram, Balamurugan; Pandian, Nagakannan; Mall, Raghvendra; Wang, Yaqiu; Sarkar, Roman; Kim, Hee Jin; Malireddi, R. K. Subbarao; Karki, Rajendra; Janke, Laura J.; Vogel, Peter; Kanneganti, Thirumala-Devi (2023-06-22).
1224:
Sundaram, Balamurugan; Pandian, Nagakannan; Mall, Raghvendra; Wang, Yaqiu; Sarkar, Roman; Kim, Hee Jin; Malireddi, R.K. Subbarao; Karki, Rajendra; Janke, Laura J.; Vogel, Peter; Kanneganti, Thirumala-Devi (June 2023).
3541:
Schifanella, Luca; Anderson, Jodi; Wieking, Garritt; Southern, Peter J.; Antinori, Spinello; Galli, Massimo; Corbellino, Mario; Lai, Alessia; Klatt, Nichole; Schacker, Timothy W.; Haase, Ashley T. (2023-05-29).
690:
139:, and potentially other yet to be identified molecules cleaved by caspases. Moreover, caspase-8 is essential for cell death in PANoptosis but needs to be inactivated or inhibited to induce necroptosis.
970:
1920:
Sborgi, Lorenzo; RΓΌhl, Sebastian; Mulvihill, Estefania; Pipercevic, Joka; Heilig, Rosalie; Stahlberg, Henning; Farady, Christopher J.; MΓΌller, Daniel J.; Broz, Petr; Hiller, Sebastian (2016-08-15).
1652:
2455:
Kuriakose, Teneema; Man, Si Ming; Malireddi, R. K. Subbarao; Karki, Rajendra; Kesavardhana, Sannula; Place, David E.; Neale, Geoffrey; Vogel, Peter; Kanneganti, Thirumala-Devi (2016-08-05).
850:
Kuriakose, Teneema; Man, Si Ming; Malireddi, R.K. Subbarao; Karki, Rajendra; Kesavardhana, Sannula; Place, David E.; Neale, Geoffrey; Vogel, Peter; Kanneganti, Thirumala-Devi (2016-08-05).
775:
73:
Emerging genetic, molecular, and biochemical studies have identified extensive crosstalk among the molecular components across various cell death pathways in response to a variety of
30:
and receptor-interacting protein kinases (RIPKs) through multiprotein PANoptosome complexes. The assembly of the PANoptosome cell death complex occurs in response to germline-encoded
717:
572:
syndromes. Treatments that block TNF and IFN-Ξ³ to prevent PANoptosis have provided therapeutic benefit in preclinical models of cytokine storm syndromes, including cytokine shock,
1853:
Aglietti, Robin A.; Estevez, Alberto; Gupta, Aaron; Ramirez, Monica
Gonzalez; Liu, Peter S.; Kayagaki, Nobuhiko; Ciferri, Claudio; Dixit, Vishva M.; Dueber, Erin C. (2016-07-12).
744:
475:
Treatment of cancer cells with the PANoptosis-inducing agents TNF and IFN-Ξ³ can reduce tumor size in preclinical models. The combination of the nuclear export inhibitor
802:
2966:
Malireddi, R. K. Subbarao; Karki, Rajendra; Sundaram, Balamurugan; Kancharana, Balabhaskararao; Lee, SangJoon; Samir, Parimal; Kanneganti, Thirumala-Devi (2021-07-21).
994:
Malireddi, R. K. Subbarao; Karki, Rajendra; Sundaram, Balamurugan; Kancharana, Balabhaskararao; Lee, SangJoon; Samir, Parimal; Kanneganti, Thirumala-Devi (2021-07-21).
3760:
Subbarao
Malireddi, R.K.; Karki, Rajendra; Sundaram, Balamurugan; Kancharana, Balabhaskararao; Lee, SangJoon; Samir, Parimal; Kanneganti, Thirumala-Devi (2021-07-21).
1167:
Wang, Yaqiu; Pandian, Nagakannan; Han, Joo-Hui; Sundaram, Balamurugan; Lee, SangJoon; Karki, Rajendra; Guy, Clifford S.; Kanneganti, Thirumala-Devi (2022-09-28).
2157:
Sun, Liming; Wang, Huayi; Wang, Zhigao; He, Sudan; Chen, She; Liao, Daohong; Wang, Lai; Yan, Jiacong; Liu, Weilong; Lei, Xiaoguang; Wang, Xiaodong (2012-01-20).
607:
826:
2572:
Malireddi, R. K. Subbarao; Kesavardhana, Sannula; Karki, Rajendra; Kancharana, Balabhaskararao; Burton, Amanda R.; Kanneganti, Thirumala-Devi (2020-12-11).
1466:
Malireddi, R. K. Subbarao; Kesavardhana, Sannula; Karki, Rajendra; Kancharana, Balabhaskararao; Burton, Amanda R.; Kanneganti, Thirumala-Devi (2020-12-11).
2680:
Malireddi, R. K. Subbarao; Bynigeri, Ratnakar R.; Mall, Raghvendra; Connelly, Jon P.; Pruett-Miller, Shondra M.; Kanneganti, Thirumala-Devi (2023-10-20).
3138:
Mall, Raghvendra; Bynigeri, Ratnakar R.; Karki, Rajendra; Malireddi, R. K. Subbarao; Sharma, Bhesh Raj; Kanneganti, Thirumala-Devi (December 2022).
3311:"Potential role of PANoptosis in neuronal cell death: commentary on "PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons""
4001:"Synergism of TNF-Ξ± and IFN-Ξ³ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes"
3705:"Synergism of TNF-Ξ± and IFN-Ξ³ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes"
1054:"Synergism of TNF-Ξ± and IFN-Ξ³ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes"
573:
1733:
Shi, Jianjin; Zhao, Yue; Wang, Kun; Shi, Xuyan; Wang, Yue; Huang, Huanwei; Zhuang, Yinghua; Cai, Tao; Wang, Fengchao; Shao, Feng (2015-10-29).
1796:
He, Wan-ting; Wan, Haoqiang; Hu, Lichen; Chen, Pengda; Wang, Xin; Huang, Zhe; Yang, Zhang-Hua; Zhong, Chuan-Qi; Han, Jiahuai (December 2015).
2786:"Caspase-8, receptor-interacting protein kinase 1 (RIPK1), and RIPK3 regulate retinoic acid-induced cell differentiation and necroptosis"
101:
pathway, these mechanisms are separate processes that are associated with distinct triggers, protein complexes, and execution pathways.
89:
were described as two major inflammatory cell death pathways. While the PANoptosis pathway has some molecular components in common with
1112:"ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection"
507:+ depletion downstream of heme-containing triggers. Deletion of NLRC5 protects against not only hemolytic disease models, but also
2682:"Inflammatory cell death, PANoptosis, screen identifies host factors in coronavirus innate immune response as therapeutic targets"
3647:
Banoth, Balaji; Tuladhar, Shraddha; Karki, Rajendra; Sharma, Bhesh Raj; Briard, Benoit; Kesavardhana, Sannula; Burton, Amanda;
1401:
Lee, SangJoon; Karki, Rajendra; Wang, Yaqiu; Nguyen, Lam Nhat; Kalathur, Ravi C.; Kanneganti, Thirumala-Devi (September 2021).
35:
39:
3602:"Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)"
2515:"Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)"
1339:"Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)"
3544:"The Defenders of the Alveolus Succumb in COVID-19 Pneumonia to SARS-CoV-2 and Necroptosis, Pyroptosis, and PANoptosis"
2092:"Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis"
581:
512:
2457:"ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways"
852:"ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways"
504:
2043:"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta"
144:
Summary of the different morphologies, mechanisms and outcomes of apoptosis, pyroptosis, necroptosis, and PANoptosis
135:
inhibition. On the other hand, PANoptosis is driven by caspases and RIPKs and is executed by gasdermins, MLKL,
3878:"NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress"
2090:
Zhao, Jie; Jitkaew, Siriporn; Cai, Zhenyu; Choksi, Swati; Li, Qiuning; Luo, Ji; Liu, Zheng-Gang (2012-04-03).
3762:"Inflammatory cell death, PANoptosis, mediated by cytokines in diverse cancer lineages inhibits tumor growth"
3653:"ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis)"
2968:"Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth"
996:"Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth"
544:
The regulation of PANoptosis involves numerous PANoptosomes, which include multiple sensor molecules such as
31:
3140:"Pancancer transcriptomic profiling identifies key PANoptosis markers as therapeutic targets for oncology"
421:
3197:"Characterization of PANoptosis patterns predicts survival and immunotherapy response in gastric cancer"
3648:
447:
infections, where the combined loss of caspases and RIPK3 significantly protects cells from death.
2784:
Someda, Masataka; Kuroki, Shunsuke; Miyachi, Hitoshi; Tachibana, Makoto; Yonehara, Shin (May 2020).
1653:"St. Jude scientists solve decades long mystery of NLRC5 sensor function in cell death and disease"
425:
infections, PANoptosis is induced through the RIPK1-PANoptosome, and the deletion of caspase-8 and
2629:
Chen, Wen; Gullett, Jessica M.; Tweedell, Rebecca E.; Kanneganti, Thirumala-Devi (November 2023).
2390:"NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1Ξ²-mediated osteomyelitis"
435:
infection, PANoptosis occurs through the AIM2-PANoptosome. PANoptosis has also been observed in
1169:"Single cell analysis of PANoptosome cell death complexes through an expansion microscopy method"
2631:"Innate immune inflammatory cell death: PANoptosis and PANoptosomes in host defense and disease"
2159:"Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase"
636:"Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes"
608:"St. Jude finds NLRP12 as a new drug target for infection, inflammation and hemolytic diseases"
443:
131:. In contrast, necroptosis occurs via RIPK1/3-mediated MLKL activation, which is downstream of
4061:
3423:
Zhu, Peng; Ke, Zhuo-Ran; Chen, Jing-Xian; Li, Shi-Jin; Ma, Tian-Liang; Fan, Xiao-Lei (2023).
463:
1592:"NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation"
1281:"Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense"
3889:
2855:
2737:
Jiang, Mingxia; Qi, Ling; Li, Lisha; Wu, Yiming; Song, Dongfeng; Li, Yanjing (2021-10-01).
2401:
2336:
2103:
1991:
1866:
1746:
1414:
431:
400:
8:
2223:
437:
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1995:
1870:
1750:
1626:
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1418:
1253:
1226:
827:"Breaking the dogma: Key cell death regulator has more than one way to get the job done"
4033:
4000:
3975:
3942:
3852:
3820:"ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis"
3819:
3794:
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3601:
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1201:
1168:
1144:
1111:
1086:
1053:
1028:
995:
944:
909:
884:
851:
718:"ZBP1 links interferon treatment and dangerous inflammatory cell death during COVID-19"
2059:
2042:
691:"Promising preclinical cancer therapy harnesses a newly discovered cell death pathway"
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3923:
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3781:
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Galluzzi, Lorenzo; Kepp, Oliver; Chan, Francis Ka-Ming; Kroemer, Guido (2017-01-24).
2188:
2180:
2139:
2121:
2072:
2064:
2015:
2007:
1959:
1941:
1902:
1884:
1835:
1817:
1770:
1762:
1715:
1697:
1631:
1613:
1568:
1550:
1531:"NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs"
1505:
1487:
1448:
1430:
1378:
1360:
1318:
1300:
1258:
1227:"NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs"
1206:
1188:
1149:
1131:
1091:
1073:
1033:
1015:
949:
931:
889:
871:
667:
655:
396:
3425:"Advances in mechanism and regulation of PANoptosis: Prospects in disease treatment"
1798:"Gasdermin D is an executor of pyroptosis and required for interleukin-1Ξ² secretion"
1279:
Zheng, Min; Karki, Rajendra; Vogel, Peter; Kanneganti, Thirumala-Devi (2020-04-30).
4028:
4012:
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3831:
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1123:
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1011:
1007:
971:"Diet affects mix of intestinal bacteria and the risk of inflammatory bone disease"
939:
921:
879:
863:
663:
647:
457:
3026:"Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer"
1922:"GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death"
910:"Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer"
3835:
2574:"RIPK1 Distinctly Regulates Yersinia-Induced Inflammatory Cell Death, PANoptosis"
1468:"RIPK1 Distinctly Regulates Yersinia-Induced Inflammatory Cell Death, PANoptosis"
651:
34:
sensing pathogens, including bacterial, viral, and fungal infections, as well as
4016:
3901:
3720:
3500:
3441:
3268:
3212:
3098:
3041:
2848:
Proceedings of the
National Academy of Sciences of the United States of America
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2472:
2394:
Proceedings of the
National Academy of Sciences of the United States of America
2175:
2158:
2096:
Proceedings of the
National Academy of Sciences of the United States of America
1859:
Proceedings of the
National Academy of Sciences of the United States of America
1608:
1546:
1426:
1403:"AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence"
1296:
1243:
1184:
1127:
1069:
926:
867:
569:
3385:
2801:
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3327:
3277:
3220:
3163:
3155:
3106:
3049:
2991:
2934:
2877:
2809:
2762:
2739:"Caspase-8: A key protein of cross-talk signal way in "PANoptosis" in cancer"
2705:
2654:
2597:
2540:
2531:
2480:
2423:
2356:
2290:
2231:
2184:
2125:
2068:
2011:
1945:
1888:
1855:"GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes"
1821:
1766:
1735:"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death"
1701:
1617:
1554:
1491:
1434:
1364:
1355:
1304:
1192:
1135:
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2414:
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1979:
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635:
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3803:
3746:
3688:
3633:
3585:
3527:
3468:
3401:
3354:
3295:
3228:
3181:
3124:
3067:
3009:
2952:
2895:
2827:
2770:
2723:
2666:
2615:
2558:
2498:
2441:
2374:
2308:
2249:
2192:
2143:
2076:
2019:
1963:
1906:
1839:
1774:
1719:
1635:
1572:
1509:
1452:
1382:
1322:
1262:
1210:
1153:
1095:
1037:
953:
893:
671:
565:
102:
2646:
2388:
Gurung, Prajwal; Burton, Amanda; Kanneganti, Thirumala-Devi (2016-04-19).
395:
PANoptosis has now been identified in a variety of infections, incluiding
3759:
524:
404:
94:
86:
2844:"Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis"
2348:
2003:
1813:
1758:
3252:"Exploring PANoptosis in breast cancer based on scRNA-seq and bulk-seq"
3087:
Translational
Research: The Journal of Laboratory and Clinical Medicine
2325:"Dietary modulation of the microbiome affects autoinflammatory disease"
480:
455:
PANoptosis also occurs in fungal infections, including those caused by
110:
90:
82:
23:
3943:"The 'Cytokine Storm': molecular mechanisms and therapeutic prospects"
2926:
2754:
1693:
776:"In the lab, St. Jude scientists identify possible COVID-19 treatment"
3484:"Recent advances in ZBP1-derived PANoptosis against viral infections"
483:
can also cause PANoptosis and regress tumors in preclinical models.
476:
132:
124:
114:
106:
98:
2571:
1465:
584:, suggesting the therapeutic potential of modulating this pathway.
74:
43:
3540:
1976:
46:
that are released during infections, inflammatory conditions, and
508:
78:
27:
3250:
He, Puxing; Ma, Yixuan; Wu, Yaolu; Zhou, Qing; Du, Huan (2023).
2965:
993:
105:-dependent pyroptosis involves inflammatory caspases, including
3368:
Qi, Zehong; Zhu, Lili; Wang, Kangkai; Wang, Nian (2023-11-15).
3081:
Sharma, Bhesh Raj; Kanneganti, Thirumala-Devi (February 2023).
2840:
2511:
1335:
577:
561:
496:
67:
47:
3195:
Pan, Hongda; Pan, Jingxin; Li, Pei; Gao, Jianpeng (May 2022).
2679:
2628:
2041:
Martinon, Fabio; Burns, Kimberly; Tschopp, JΓΌrg (July 2002).
1919:
557:
545:
532:
528:
492:
426:
136:
128:
63:
59:
2783:
745:"The PANoptosome: a new frontier in innate immune responses"
3997:
3941:
Karki, Rajendra; Kanneganti, Thirumala-Devi (August 2021).
3701:
3598:
2909:
Cai, Hantao; Lv, Mingming; Wang, Tingting (December 2023).
1852:
1050:
634:
Pandeya, Ankit; Kanneganti, Thirumala-Devi (January 2024).
553:
549:
500:
408:
55:
51:
3370:"PANoptosis: Emerging mechanisms and disease implications"
3137:
2454:
2265:"Necroptosis: a regulated inflammatory mode of cell death"
1980:"Non-canonical inflammasome activation targets caspase-11"
1588:
849:
3646:
1278:
26:
pathway initiated by innate immune sensors and driven by
2321:
2205:
1527:
1223:
77:
and innate immune triggers. Historically, inflammatory
3816:
2387:
1166:
22:
is a prominent innate immune, inflammatory, and lytic
3874:
1676:
Man, Si Ming; Kanneganti, Thirumala-Devi (May 2015).
3022:
2089:
2040:
906:
803:"Discovering the secrets of the enigmatic caspase-6"
1108:
2911:"PANoptosis in cancer, the triangle of cell death"
2263:Dhuriya, Yogesh K.; Sharma, Divakar (2018-07-06).
2208:"Necroptosis: Mechanisms and Relevance to Disease"
1400:
531:is a key executioner in this context. Deletion of
633:
4053:
3606:Frontiers in Cellular and Infection Microbiology
3080:
2519:Frontiers in Cellular and Infection Microbiology
1343:Frontiers in Cellular and Infection Microbiology
3940:
70:-PANoptosomes, have been characterized so far.
1732:
3367:
3309:Sun, Yanyan; Zhu, Changlian (February 2023).
3083:"Inflammasome signaling in colorectal cancer"
2262:
2156:
1675:
50:. Several PANoptosome complexes, such as the
3422:
3194:
2736:
1795:
527:(HS), such as fever, during infection, and
523:Additionally, PANoptosis can be induced by
3249:
4032:
3974:
3917:
3851:
3793:
3736:
3678:
3668:
3623:
3613:
3575:
3517:
3499:
3458:
3440:
3344:
3326:
3285:
3267:
3171:
3114:
3057:
2999:
2942:
2908:
2885:
2867:
2817:
2713:
2605:
2548:
2530:
2488:
2431:
2413:
2364:
2298:
2280:
2239:
2174:
2133:
2115:
2058:
1953:
1896:
1878:
1829:
1709:
1625:
1607:
1562:
1499:
1442:
1372:
1354:
1312:
1252:
1242:
1200:
1143:
1085:
1027:
943:
925:
883:
539:
486:
1678:"Regulation of inflammasome activation"
414:
4054:
3308:
1647:
1645:
1584:
1582:
1523:
1521:
1519:
1396:
1394:
1392:
1274:
1272:
965:
963:
36:pathogen-associated molecular patterns
3481:
629:
627:
602:
600:
598:
596:
499:-mediated PANoptosis is activated by
381:
2224:10.1146/annurev-pathol-052016-100247
1173:Cellular and Molecular Life Sciences
797:
795:
770:
768:
766:
764:
739:
737:
712:
710:
685:
683:
681:
450:
40:damage-associated molecular patterns
32:pattern-recognition receptors (PRRs)
3482:Oh, SuHyeon; Lee, SangJoon (2023).
3201:Clinical Immunology (Orlando, Fla.)
1642:
1579:
1516:
1389:
1269:
960:
491:More recent evidence suggests that
390:
13:
3548:The Journal of Infectious Diseases
1217:
1102:
1044:
987:
624:
593:
582:hemophagocytic lymphohistiocytosis
14:
4073:
843:
792:
761:
734:
707:
678:
97:, as well as with the non-lytic
3991:
3934:
3868:
3810:
3753:
3695:
3640:
3592:
3534:
3475:
3416:
3361:
3302:
3243:
3188:
3131:
3074:
3016:
2959:
2902:
2834:
2777:
2743:International Journal of Cancer
2730:
2673:
2622:
2565:
2505:
2448:
2381:
2315:
2256:
2199:
2150:
2083:
2034:
1970:
1913:
1846:
1789:
1726:
1669:
1459:
1329:
1160:
900:
16:Inflammatory cell death pathway
3778:10.4049/immunohorizons.2100059
2984:10.4049/immunohorizons.2100059
2790:Cell Death and Differentiation
2635:European Journal of Immunology
2590:10.4049/immunohorizons.2000097
1484:10.4049/immunohorizons.2000097
1012:10.4049/immunohorizons.2100059
819:
127:in humans, and is executed by
1:
2060:10.1016/s1097-2765(02)00599-3
587:
3836:10.1016/j.celrep.2021.109858
3315:Neural Regeneration Research
2269:Journal of Neuroinflammation
652:10.1016/j.molmed.2023.10.001
640:Trends in Molecular Medicine
568:, inflammatory disease, and
429:prevents cell death. During
7:
422:Yersinia pseudotuberculosis
10:
4078:
4017:10.1016/j.cell.2020.11.025
3902:10.1038/s41467-024-45466-x
3721:10.1016/j.cell.2020.11.025
3649:Kanneganti, Thirumala-Devi
3501:10.3389/fimmu.2023.1148727
3442:10.3389/fimmu.2023.1120034
3269:10.3389/fendo.2023.1164930
3256:Frontiers in Endocrinology
3213:10.1016/j.clim.2022.109019
3099:10.1016/j.trsl.2022.09.002
3042:10.1172/jci.insight.136720
2698:10.1038/s42003-023-05414-9
2473:10.1126/sciimmunol.aag2045
2212:Annual Review of Pathology
2176:10.1016/j.cell.2011.11.031
1609:10.1016/j.cell.2024.05.034
1547:10.1016/j.cell.2023.05.005
1427:10.1038/s41586-021-03875-8
1297:10.1016/j.cell.2020.03.040
1244:10.1016/j.cell.2023.05.005
1185:10.1007/s00018-022-04564-z
1128:10.1126/sciimmunol.abo6294
1070:10.1016/j.cell.2020.11.025
927:10.1172/jci.insight.136720
868:10.1126/sciimmunol.aag2045
3386:10.1016/j.lfs.2023.122158
2802:10.1038/s41418-019-0434-2
2282:10.1186/s12974-018-1235-0
470:
300:
221:
180:
113:in mice, and caspases-1,
3959:10.1016/j.it.2021.06.001
3670:10.1074/jbc.RA120.015924
3615:10.3389/fcimb.2020.00237
3328:10.4103/1673-5374.346483
2532:10.3389/fcimb.2020.00237
1356:10.3389/fcimb.2020.00237
518:
3488:Frontiers in Immunology
3429:Frontiers in Immunology
3036:(12): e136720, 136720.
2869:10.1073/pnas.2207240119
2415:10.1073/pnas.1601636113
2117:10.1073/pnas.1200012109
1938:10.15252/embj.201694696
1880:10.1073/pnas.1607769113
305:IL-1b and IL-18 release
85: and RIPK-driven
3560:10.1093/infdis/jiad056
3156:10.1093/narcan/zcac033
2686:Communications Biology
444:Listeria monocytogenes
401:herpes simplex virus 1
3882:Nature Communications
2647:10.1002/eji.202250235
1682:Immunological Reviews
1602:(15): 4061β4077.e17.
1541:(13): 2783β2801.e20.
1237:(13): 2783β2801.e20.
540:Therapeutic Potential
487:Hematologic disorders
464:Aspergillus fumigatus
362:Programmed cell death
3947:Trends in Immunology
3663:(295): 18276β18283.
432:Francisella novicida
415:Bacterial Infections
245:Gasdermin activation
3894:2024NatCo..15.1739H
3608:. 29:10:237.: 237.
2921:(24): 22206β22223.
2860:2022PNAS..11907240R
2854:(41): e2207240119.
2406:2016PNAS..113.4452G
2349:10.1038/nature13788
2341:2014Natur.516..246L
2108:2012PNAS..109.5322Z
2004:10.1038/nature10558
1996:2011Natur.479..117K
1871:2016PNAS..113.7858A
1814:10.1038/cr.2015.139
1759:10.1038/nature15514
1751:2015Natur.526..660S
1419:2021Natur.597..415L
438:Salmonella enterica
4011:(1): 149β168.e17.
3715:(1): 149β168.e17.
2461:Science Immunology
1291:(3): 674β687.e13.
1116:Science Immunology
1064:(1): 149β168.e17.
856:Science Immunology
382:Clinical Relevance
226:Caspase activation
3554:(11): 1245β1254.
2927:10.1002/cam4.6803
2755:10.1002/ijc.33698
2400:(16): 4452β4457.
2335:(7530): 246β249.
2102:(14): 5322β5327.
1990:(7371): 117β121.
1932:(16): 1766β1778.
1865:(28): 7858β7863.
1808:(12): 1285β1298.
1745:(7575): 660β665.
1694:10.1111/imr.12296
1413:(7876): 415β419.
451:Fungal Infections
397:influenza A virus
379:
378:
145:
4069:
4047:
4046:
4036:
3995:
3989:
3988:
3978:
3938:
3932:
3931:
3921:
3872:
3866:
3865:
3855:
3814:
3808:
3807:
3797:
3757:
3751:
3750:
3740:
3699:
3693:
3692:
3682:
3672:
3644:
3638:
3637:
3627:
3617:
3596:
3590:
3589:
3579:
3538:
3532:
3531:
3521:
3503:
3479:
3473:
3472:
3462:
3444:
3420:
3414:
3413:
3365:
3359:
3358:
3348:
3330:
3306:
3300:
3299:
3289:
3271:
3247:
3241:
3240:
3192:
3186:
3185:
3175:
3135:
3129:
3128:
3118:
3078:
3072:
3071:
3061:
3020:
3014:
3013:
3003:
2963:
2957:
2956:
2946:
2906:
2900:
2899:
2889:
2871:
2838:
2832:
2831:
2821:
2796:(5): 1539β1553.
2781:
2775:
2774:
2749:(7): 1408β1420.
2734:
2728:
2727:
2717:
2677:
2671:
2670:
2661: 10423303.
2641:(11): e2250235.
2626:
2620:
2619:
2609:
2569:
2563:
2562:
2552:
2534:
2509:
2503:
2502:
2492:
2452:
2446:
2445:
2435:
2417:
2385:
2379:
2378:
2368:
2319:
2313:
2312:
2302:
2284:
2260:
2254:
2253:
2243:
2203:
2197:
2196:
2178:
2169:(1β2): 213β227.
2154:
2148:
2147:
2137:
2119:
2087:
2081:
2080:
2062:
2038:
2032:
2031:
1974:
1968:
1967:
1957:
1926:The EMBO Journal
1917:
1911:
1910:
1900:
1882:
1850:
1844:
1843:
1833:
1793:
1787:
1786:
1730:
1724:
1723:
1713:
1673:
1667:
1666:
1664:
1663:
1649:
1640:
1639:
1629:
1611:
1586:
1577:
1576:
1566:
1525:
1514:
1513:
1503:
1463:
1457:
1456:
1446:
1398:
1387:
1386:
1376:
1358:
1333:
1327:
1326:
1316:
1276:
1267:
1266:
1256:
1246:
1221:
1215:
1214:
1204:
1164:
1158:
1157:
1147:
1122:(74): eabo6294.
1106:
1100:
1099:
1089:
1048:
1042:
1041:
1031:
991:
985:
984:
982:
981:
967:
958:
957:
947:
929:
904:
898:
897:
887:
847:
841:
840:
838:
837:
823:
817:
816:
814:
813:
799:
790:
789:
787:
786:
772:
759:
758:
756:
755:
741:
732:
731:
729:
728:
714:
705:
704:
702:
701:
687:
676:
675:
666: 10842719.
631:
622:
621:
619:
618:
604:
458:Candida albicans
391:Viral Infections
149:
148:
143:
4077:
4076:
4072:
4071:
4070:
4068:
4067:
4066:
4052:
4051:
4050:
3996:
3992:
3939:
3935:
3873:
3869:
3815:
3811:
3758:
3754:
3700:
3696:
3645:
3641:
3597:
3593:
3539:
3535:
3480:
3476:
3421:
3417:
3366:
3362:
3307:
3303:
3248:
3244:
3193:
3189:
3136:
3132:
3079:
3075:
3021:
3017:
2964:
2960:
2915:Cancer Medicine
2907:
2903:
2839:
2835:
2782:
2778:
2735:
2731:
2678:
2674:
2627:
2623:
2584:(12): 789β796.
2570:
2566:
2510:
2506:
2453:
2449:
2386:
2382:
2320:
2316:
2261:
2257:
2204:
2200:
2155:
2151:
2088:
2084:
2039:
2035:
1975:
1971:
1918:
1914:
1851:
1847:
1794:
1790:
1731:
1727:
1674:
1670:
1661:
1659:
1651:
1650:
1643:
1587:
1580:
1526:
1517:
1478:(12): 789β796.
1464:
1460:
1399:
1390:
1334:
1330:
1277:
1270:
1222:
1218:
1165:
1161:
1107:
1103:
1049:
1045:
992:
988:
979:
977:
969:
968:
961:
905:
901:
848:
844:
835:
833:
825:
824:
820:
811:
809:
801:
800:
793:
784:
782:
774:
773:
762:
753:
751:
743:
742:
735:
726:
724:
716:
715:
708:
699:
697:
689:
688:
679:
632:
625:
616:
614:
606:
605:
594:
590:
542:
521:
489:
473:
453:
417:
393:
384:
155:Characteristics
17:
12:
11:
5:
4075:
4065:
4064:
4049:
4048:
3990:
3953:(8): 681β705.
3933:
3867:
3809:
3772:(7): 568β580.
3766:ImmunoHorizons
3752:
3694:
3639:
3591:
3533:
3474:
3415:
3360:
3321:(2): 339β340.
3301:
3242:
3187:
3150:(4): zcac033.
3130:
3073:
3015:
2978:(7): 568β580.
2972:ImmunoHorizons
2958:
2901:
2833:
2776:
2729:
2672:
2621:
2578:ImmunoHorizons
2564:
2504:
2467:(2): aag2045.
2447:
2380:
2314:
2255:
2198:
2149:
2082:
2053:(2): 417β426.
2047:Molecular Cell
2033:
1969:
1912:
1845:
1788:
1725:
1668:
1657:www.stjude.org
1641:
1578:
1515:
1472:ImmunoHorizons
1458:
1388:
1328:
1268:
1216:
1159:
1101:
1043:
1006:(7): 568β580.
1000:ImmunoHorizons
986:
975:www.stjude.org
959:
899:
862:(2): aag2045.
842:
831:www.stjude.org
818:
807:www.stjude.org
791:
780:www.stjude.org
760:
749:www.stjude.org
733:
722:www.stjude.org
706:
695:www.stjude.org
677:
623:
612:www.stjude.org
591:
589:
586:
570:cytokine storm
541:
538:
520:
517:
488:
485:
472:
469:
452:
449:
416:
413:
392:
389:
383:
380:
377:
376:
373:
370:
367:
364:
358:
357:
354:
351:
348:
345:
339:
338:
335:
332:
329:
326:
320:
319:
316:
313:
310:
307:
302:
298:
297:
294:
291:
288:
285:
279:
278:
275:
272:
269:
266:
260:
259:
256:
253:
250:
247:
241:
240:
237:
234:
231:
228:
223:
219:
218:
215:
212:
209:
206:
204:Pore formation
200:
199:
196:
193:
190:
187:
182:
178:
177:
172:
167:
162:
157:
152:
15:
9:
6:
4:
3:
2:
4074:
4063:
4060:
4059:
4057:
4044:
4040:
4035:
4030:
4026:
4022:
4018:
4014:
4010:
4006:
4002:
3994:
3986:
3982:
3977:
3972:
3968:
3964:
3960:
3956:
3952:
3948:
3944:
3937:
3929:
3925:
3920:
3915:
3911:
3907:
3903:
3899:
3895:
3891:
3887:
3883:
3879:
3871:
3863:
3859:
3854:
3849:
3845:
3841:
3837:
3833:
3830:(3): 109858.
3829:
3825:
3821:
3813:
3805:
3801:
3796:
3791:
3787:
3783:
3779:
3775:
3771:
3767:
3763:
3756:
3748:
3744:
3739:
3734:
3730:
3726:
3722:
3718:
3714:
3710:
3706:
3698:
3690:
3686:
3681:
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1802:Cell Research
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41:
37:
33:
29:
25:
21:
4062:Cell biology
4008:
4004:
3993:
3950:
3946:
3936:
3885:
3881:
3870:
3827:
3824:Cell Reports
3823:
3812:
3769:
3765:
3755:
3712:
3708:
3697:
3660:
3656:
3642:
3605:
3594:
3551:
3547:
3536:
3491:
3487:
3477:
3432:
3428:
3418:
3377:
3373:
3363:
3318:
3314:
3304:
3259:
3255:
3245:
3204:
3200:
3190:
3147:
3143:
3133:
3090:
3086:
3076:
3033:
3029:
3018:
2975:
2971:
2961:
2918:
2914:
2904:
2851:
2847:
2836:
2793:
2789:
2779:
2746:
2742:
2732:
2689:
2685:
2675:
2638:
2634:
2624:
2581:
2577:
2567:
2522:
2518:
2507:
2464:
2460:
2450:
2397:
2393:
2383:
2332:
2328:
2317:
2272:
2268:
2258:
2215:
2211:
2201:
2166:
2162:
2152:
2099:
2095:
2085:
2050:
2046:
2036:
1987:
1983:
1972:
1929:
1925:
1915:
1862:
1858:
1848:
1805:
1801:
1791:
1742:
1738:
1728:
1685:
1681:
1671:
1660:. Retrieved
1656:
1599:
1595:
1538:
1534:
1475:
1471:
1461:
1410:
1406:
1346:
1342:
1331:
1288:
1284:
1234:
1230:
1219:
1176:
1172:
1162:
1119:
1115:
1104:
1061:
1057:
1046:
1003:
999:
989:
978:. Retrieved
974:
917:
913:
902:
859:
855:
845:
834:. Retrieved
830:
821:
810:. Retrieved
806:
783:. Retrieved
779:
752:. Retrieved
748:
725:. Retrieved
721:
698:. Retrieved
694:
646:(1): 74β88.
643:
639:
615:. Retrieved
611:
566:inflammation
543:
522:
490:
474:
462:
456:
454:
442:
436:
430:
420:
418:
403:(HSV1), and
394:
385:
361:
343:Inflammation
342:
324:DAMP release
323:
304:
282:
263:
244:
225:
203:
184:
174:
169:
164:
159:
154:
142:
141:
121:
115:
103:Inflammasome
72:
19:
18:
3888:(1): 1739.
3657:J Biol Chem
3494:: 1148727.
3435:: 1120034.
3262:: 1164930.
3030:JCI Insight
2692:(1): 1071.
2218:: 103β130.
1688:(1): 6β21.
1179:(10): 531.
914:JCI Insight
576:infection,
525:heat stress
405:coronavirus
181:Morphology
170:Necroptosis
129:gasdermin D
95:necroptosis
87:necroptosis
3380:: 122158.
3207:: 109019.
3144:NAR Cancer
2275:(1): 199.
1662:2024-06-18
980:2020-09-11
836:2021-11-16
812:2021-11-16
785:2021-11-16
754:2021-11-16
727:2022-06-02
700:2021-11-16
617:2024-03-07
588:References
574:SARS-CoV-2
222:Mechanism
185:Cell lysis
175:PANoptosis
165:Pyroptosis
111:caspase-11
91:pyroptosis
83:pyroptosis
81:-mediated
24:cell death
20:PANoptosis
4025:0092-8674
3967:1471-4906
3910:2041-1723
3844:2211-1247
3786:2573-7732
3729:1097-4172
3568:1537-6613
3510:1664-3224
3451:1664-3224
3410:263775829
3394:1879-0631
3337:1673-5374
3278:1664-2392
3237:248362726
3221:1521-7035
3164:2632-8674
3107:1878-1810
3093:: 45β52.
3050:2379-3708
2992:2573-7732
2935:2045-7634
2878:1091-6490
2810:1476-5403
2763:1097-0215
2706:2399-3642
2655:1521-4141
2598:2573-7732
2541:2235-2988
2481:2470-9468
2424:1091-6490
2357:1476-4687
2291:1742-2094
2232:1553-4014
2185:1097-4172
2126:1091-6490
2069:1097-2765
2012:1476-4687
1946:1460-2075
1889:1091-6490
1822:1748-7838
1767:1476-4687
1702:1600-065X
1618:0092-8674
1555:1097-4172
1492:2573-7732
1435:1476-4687
1365:2235-2988
1305:1097-4172
1193:1420-9071
1136:2470-9468
1078:1097-4172
1020:2573-7732
936:2379-3708
876:2470-9468
660:1471-499X
477:selinexor
318:Possible
160:Apoptosis
133:caspase-8
107:caspase-1
99:apoptosis
75:pathogens
44:cytokines
4056:Category
4043:33278357
3985:34217595
3928:38409108
3919:10897308
3862:34686350
3804:34290111
3747:33278357
3689:33109609
3651:(2020).
3634:32547960
3586:36869698
3577:10226656
3528:37261341
3519:10228733
3469:36845112
3402:37806654
3355:35900425
3296:37455906
3287:10338225
3229:35470064
3182:36329783
3125:36150688
3068:32554929
3010:34290111
2953:38069556
2944:10757109
2896:36191211
2828:31659279
2771:34028029
2724:37864059
2715:10589293
2667:36782083
2616:33310881
2559:32547960
2499:27917412
2442:27071119
2375:25274309
2309:29980212
2250:27959630
2193:22265413
2144:22421439
2077:12191486
2020:22002608
1964:27418190
1907:27339137
1840:26611636
1775:26375003
1720:25879280
1636:38878777
1627:11283362
1573:37267949
1564:10330523
1510:33310881
1453:34471287
1383:32547960
1323:32298652
1263:37267949
1254:10330523
1211:36169732
1154:35587515
1096:33278357
1038:34290111
954:32554929
894:27917412
672:37977994
515:models.
301:Outcome
28:caspases
4034:7674074
3976:9310545
3890:Bibcode
3853:8853634
3795:8522052
3738:7674074
3680:7939383
3625:7274033
3460:9948402
3346:9396522
3173:9623737
3116:9839553
3059:7406299
3001:8522052
2887:9565532
2856:Bibcode
2819:7206185
2607:7906112
2550:7274033
2525:: 237.
2490:5131924
2433:4843439
2402:Bibcode
2366:4268032
2337:Bibcode
2300:6035417
2241:5786374
2135:3325682
2104:Bibcode
2028:2131385
1992:Bibcode
1955:5010048
1898:4948338
1867:Bibcode
1831:4670995
1783:4407455
1747:Bibcode
1711:4400844
1501:7906112
1444:8603942
1415:Bibcode
1374:7274033
1349:: 237.
1314:7425208
1202:9545391
1145:9161373
1087:7674074
1029:8522052
945:7406299
885:5131924
509:colitis
79:caspase
62:-, and
4041:
4031:
4023:
3983:
3973:
3965:
3926:
3916:
3908:
3860:
3850:
3842:
3802:
3792:
3784:
3745:
3735:
3727:
3687:
3677:
3632:
3622:
3584:
3574:
3566:
3526:
3516:
3508:
3467:
3457:
3449:
3408:
3400:
3392:
3353:
3343:
3335:
3294:
3284:
3276:
3235:
3227:
3219:
3180:
3170:
3162:
3123:
3113:
3105:
3066:
3056:
3048:
3008:
2998:
2990:
2951:
2941:
2933:
2894:
2884:
2876:
2826:
2816:
2808:
2769:
2761:
2722:
2712:
2704:
2665:
2653:
2614:
2604:
2596:
2557:
2547:
2539:
2497:
2487:
2479:
2440:
2430:
2422:
2373:
2363:
2355:
2329:Nature
2307:
2297:
2289:
2248:
2238:
2230:
2191:
2183:
2142:
2132:
2124:
2075:
2067:
2026:
2018:
2010:
1984:Nature
1962:
1952:
1944:
1905:
1895:
1887:
1838:
1828:
1820:
1781:
1773:
1765:
1739:Nature
1718:
1708:
1700:
1634:
1624:
1616:
1571:
1561:
1553:
1508:
1498:
1490:
1451:
1441:
1433:
1407:Nature
1381:
1371:
1363:
1321:
1311:
1303:
1261:
1251:
1209:
1199:
1191:
1152:
1142:
1134:
1094:
1084:
1076:
1036:
1026:
1018:
952:
942:
934:
920:(12).
892:
882:
874:
670:
658:
580:, and
578:sepsis
562:NLRP12
560:, and
497:NLRP12
471:Cancer
120:, and
68:NLRP12
66:- and
48:cancer
42:, and
3406:S2CID
3233:S2CID
2024:S2CID
1779:S2CID
558:NLRC5
546:NLRP3
533:NINJ1
529:NINJ1
519:Fever
493:NLRC5
427:RIPK3
283:RIPK3
264:RIPK1
137:NINJ1
64:NLRC5
60:RIPK1
4039:PMID
4021:ISSN
4005:Cell
3981:PMID
3963:ISSN
3924:PMID
3906:ISSN
3858:PMID
3840:ISSN
3800:PMID
3782:ISSN
3743:PMID
3725:ISSN
3709:Cell
3685:PMID
3630:PMID
3582:PMID
3564:ISSN
3524:PMID
3506:ISSN
3465:PMID
3447:ISSN
3398:PMID
3390:ISSN
3351:PMID
3333:ISSN
3292:PMID
3274:ISSN
3225:PMID
3217:ISSN
3178:PMID
3160:ISSN
3121:PMID
3103:ISSN
3064:PMID
3046:ISSN
3006:PMID
2988:ISSN
2949:PMID
2931:ISSN
2892:PMID
2874:ISSN
2824:PMID
2806:ISSN
2767:PMID
2759:ISSN
2720:PMID
2702:ISSN
2663:PMID
2651:ISSN
2612:PMID
2594:ISSN
2555:PMID
2537:ISSN
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