866:
other vital molecules that are present during pregnancy and it was in those samples that they were able to isolate the PSGs specifically and characterize their structure. PSGs have been studied extensively in multiple mammalian species; mammals including rodents, monkeys, elk, moose, cows, sheep, and humans. Mice are the primary subject in significant portion of PSG studies. Specific structure can vary between species regarding different sugars within the carbohydrate and amino acids within the protein; all species that contain a glycoprotein will have a core protein covalently bound to a carbohydrate. This covalently bound complex structure greatly contributes to the stability of the PSG; mammalian PSGs have demonstrated continual activity when subjected to an environment from 20 to 60 °C and within a pH of 5.0-11.0. The protein portion of the PSG varies depending on the gene coding for it. Several of the genes and proteins have been characterized by common experimental methods such as polymerase chain reaction, gel electrophoresis, ELISA, and restriction enzymes. The different genes produce PSGs with varying masses that contain different exposed amino acids residues; the residues that are exposed determine the type of binding site that can be used to bind PSG.
144:
119:
366:
359:
352:
150:
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bloodstream. This includes immune responses to things such as inflammation, infection, and trauma which may occur during pregnancy. In addition PSG presence within the maternal bloodstream can induce the secretion of growth factors affecting fetal growth. Low levels of PSGs in the maternal bloodstream are associated with higher occurrences of abortion, fetal retardation, low birth weight and hypoxia.
917:
syncytiotrophoblast cells located in the placenta. Rodents also produce PSGs within their placenta but these cells are called spongiotrophoblasts. The presence of the PSGs can be recognized as early as 14 days after the initial fertilization of the egg. Throughout the course of the pregnancy the levels of PCGs within the bloodstream will continue to slowly and steadily rise.
938:
External factors can also have an effect on the presence and function of PSGs. Specifically smoking during the first trimester of pregnancy can have adverse effects of the fetus. A pregnant female who has smoked is likely to have a significantly lower blood concentration of PSGs, specifically in the
865:
The complete isolation of certain glycoproteins, later classified as pregnancy-specific, within human blood serum occurred in the early 1980s, when experimental techniques like molecular cloning became common practice. The serum was being collected during the first trimester of pregnancy to test for
955:
Though high levels of PSGs are ideal during fetal development; their concentration throughout the rest of life, excluding the times in which a female is pregnant, is ideally low. A low concentration in adults is wanted to ensure normal and effective responses from the immune system. Adults that have
934:
Antibodies can form within the body that are specific to PSGs. These antibodies, when present, will cause symptoms similar as when PSG levels are low. Rodents and monkeys that were injected with a serum composed of the antibodies demonstrated an elevated abortion rate if pregnant and an increase of
885:
cells. These receptors are present both during development and in the adult. These receptors are also similar between species. Studies comparing mice and human PSGs discovered that some human PSGs when inserted into mice demonstrated partial levels of activity, because receptors present on the mice
925:
PSGs are extremely vital to development and health of a fetus. Specifically they are important in inducing, enhancing or inhibiting an immune response. PSGs regulate lymphocytes and without the presence of the PSGs the fetus would be susceptible to various types of immune attacks from the maternal
916:
In order to characterize these separate types of PSGs, samples of the human placenta can be extracted and analyzed or they can be collected from blood. Though PSGs are abundant in the bloodstream a larger concentration is also found in the placenta, because PSGs are synthesized in the
2059:
Zhou GQ, Baranov V, Zimmermann W, Grunert F, Erhard B, Mincheva-Nilsson L, Hammarström S, Thompson J (September 1997). "Highly specific monoclonal antibody demonstrates that pregnancy-specific glycoprotein (PSG) is limited to syncytiotrophoblast in human early and term placenta".
947:
A lack of PSGs can have such a detrimental effect on the success of a pregnancy that it is a standard practice to test and measure the levels of PSGs within the maternal bloodstream during the first trimester. A low concentration level of PSGs can be an indication of
1779:
Thompson JA, Mauch EM, Chen FS, Hinoda Y, Schrewe H, Berling B, Barnert S, von Kleist S, Shively JE, Zimmermann W (February 1989). "Analysis of the size of the carcinoembryonic antigen (CEA) gene family: isolation and sequencing of N-terminal domain exons".
913:(CEA) family of genes. CEAs are immunoglobulins. Within humans there are total of 11 PSG genes located on the 19th chromosome; there are 17 genes within mice on the 7th chromosome. These genes code for PSGs that are of varying lengths of amino acids.
935:
infertility if not pregnant. The receptors of some PSGs in mice have been discovered to be receptors for certain types of viruses. The mouse hepatitis virus (MHV) has been known to bind to a receptor for PSGs that is located within the brain.
1971:
Chan WY, Borjigin J, Zheng QX, Shupert WL (October 1988). "Characterization of cDNA encoding human pregnancy-specific beta 1-glycoprotein from placenta and extraplacental tissues and their comparison with carcinoembryonic antigen".
939:
second and third trimester. The later effect on concentration correlates with restriction of fetal growth. A significant difference between the concentrations during the first trimester has not been conclusively proven.
1252:
Streydio C, Lacka K, Swillens S, Vassart G (July 1988). "The human pregnancy-specific beta 1-glycoprotein (PS beta G) and the carcinoembryonic antigen (CEA)-related proteins are members of the same multigene family".
157:
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Zheng QX, Tease LA, Shupert WL, Chan WY (March 1990). "Characterization of cDNAs of the human pregnancy-specific beta 1-glycoprotein family, a new subfamily of the immunoglobulin gene superfamily".
1610:
Khan WN, Teglund S, Bremer K, Hammarström S (1992). "The pregnancy-specific glycoprotein family of the immunoglobulin superfamily: identification of new members and estimation of family size".
894:(GAG) portion of the PG, which protrudes from the membrane of the cell. Their binding of PSG can be affected by heparin, which is a competitive inhibitor that binds to the GAG portion of a PG.
1697:
Zoubir F, Khan WN, Hammarström S (May 1990). "Carcinoembryonic antigen gene family members in submandibular salivary gland: demonstration of pregnancy-specific glycoproteins by cDNA cloning".
1639:
Streydio C, Swillens S, Georges M, Szpirer C, Vassart G (April 1990). "Structure, evolution and chromosomal localization of the human pregnancy-specific beta 1 glycoprotein gene family".
839:
is the most abundant protein found in the maternal bloodstream during the later stages of pregnancy and it is of vital importance in fetal development. The PSG functions primarily as an
2001:
Rooney BC, Horne CH, Hardman N (1989). "Molecular cloning of a cDNA for human pregnancy-specific beta 1-glycoprotein:homology with human carcinoembryonic antigen and related proteins".
1934:
Niemann SC, Flake A, Bohn H, Bartels I (1989). "Pregnancy-specific beta 1-glycoprotein: cDNA cloning, tissue expression, and species specificity of one member of the PS beta G family".
1326:
Huang F, Cockrell DC, Stephenson TR, Noyes JH, Sasser RG (October 1999). "Isolation, purification, and characterization of pregnancy-specific protein B from elk and moose placenta".
835:
family. Pregnancy-specific glycoproteins (PSGs) are a complex consisting of carbohydrate and protein, which is present in the mammalian body specifically during pregnancy. This
1455:"Human pregnancy-specific glycoprotein 1a (PSG1a) induces alternative activation in human and mouse monocytes and suppresses the accessory cell-dependent T cell proliferation"
956:
a high level of PSG within their system are significantly more likely to suffer from tumors, because the immune system is repressed from fighting of abnormal cell growth.
1872:
Khan WN, Hammarström S (1989). "Carcinoembryonic antigen gene family: molecular cloning of cDNA for a PS beta G/FL-NCA glycoprotein with a novel domain arrangement".
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2184:
1410:
Horne CH, Towler CM, Pugh-Humphreys RG, Thomson AW, Bohn H (September 1976). "Pregnancy specific beta1-glycoprotein--a product of the syncytiotrophoblast".
1903:"cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver"
1291:
Hammarström S (April 1999). "The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues".
80:
510:
59:, B1G1, CD66f, DHFRP2, FL-NCA-1/2, PBG1, PS-beta-C/D, PS-beta-G-1, PSBG-1, PSBG1, PSG95, PSGGA, PSGIIA, SP1, pregnancy specific beta-1-glycoprotein 1
3035:
909:
PSGs are synthesized through a gene's coding for a specific protein. These genes belong to a specific gene family; they are a subgroup of the
2162:
1005:
3015:
2152:
751:
3877:
2201:
2177:
3608:
1026:
3596:
3374:
2030:
Teglund S, Zhou GQ, Hammarström S (1995). "Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants".
4209:
3660:
3655:
3601:
3381:
4214:
3114:
3040:
2170:
4143:
4138:
4133:
4128:
3055:
1159:"Pregnancy-specific glycoprotein 1 induces endothelial tubulogenesis through interaction with cell surface proteoglycans"
988:
4108:
3344:
3912:
3406:
3092:
992:
1505:"A pregnancy-specific glycoprotein is expressed in the brain and serves as a receptor for mouse hepatitis virus"
3551:
3087:
2192:
4048:
3520:
3515:
3460:
3194:
2643:
1728:"Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole"
143:
118:
1213:"Isolation and characterization of complementary DNAs encoding human pregnancy-specific beta 1-glycoprotein"
553:
3742:
3465:
68:
1821:"Molecular cloning and expression of cDNA for a carcinoembryonic antigen-related fetal liver glycoprotein"
3060:
906:
in the placenta, reaching concentrations of 100 to 290 mg/L at term in the serum of pregnant women.
17:
3772:
2197:
965:
855:
156:
1049:
McLellan AS, Fischer B, Dveksler G, Hori T, Wynne F, Ball M, Okumura K, Moore T, Zimmermann W (2005).
2638:
149:
1794:
55:
3822:
2717:
2143:
1567:"Pregnancy-specific beta-1-glycoprotein in first-trimester maternal serum is influenced by smoking"
910:
828:
711:
707:
703:
699:
654:
646:
642:
638:
890:(PG) on the surface of the cell in order to bind. The PSG actually will specifically bind to the
873:
for other PSG family members have been identified, the precise receptor for PSG1 remains unknown.
3786:
2139:
870:
715:
650:
3129:
3124:
3119:
3109:
2416:
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1789:
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Leslie KK, Watanabe S, Lei KJ, Chou DY, Plouzek CA, Deng HC, Torres J, Chou JY (August 1990).
2473:
2391:
874:
859:
132:
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Lisboa FA, Warren J, Sulkowski G, Aparicio M, David G, Zudaire E, Dveksler GS (March 2011).
3710:
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1832:
1739:
1516:
88:
8:
3737:
3556:
1107:
Gray-Owen SD, Blumberg RS (June 2006). "CEACAM1: contact-dependent control of immunity".
903:
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2878:
1959:
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1387:
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1051:"Structure and evolution of the mouse pregnancy-specific glycoprotein (Psg) gene locus"
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Chen DS, Asanaka M, Yokomori K, Wang F, Hwang SB, Li HP, Lai MM (December 1995).
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96:
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1010:
National Center for
Biotechnology Information, U.S. National Library of Medicine
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cells were able to interact with the human PSG. PSGs require the presence of a
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Motrán CC, DĂaz FL, Gruppi A, Slavin D, Chatton B, Bocco JL (September 2002).
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76:
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182:
84:
1120:
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2668:
1363:"Murine CD9 is the receptor for pregnancy-specific glycoprotein 17"
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Pregnancy-specific beta-1-glycoprotein is a major product of the
820:
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for PSGs are found on many cells throughout the body including
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2523:
2518:
2411:
2337:
2332:
2322:
1156:
2058:
1609:
1325:
1251:
1027:"Entrez Gene: PSG1 pregnancy specific beta-1-glycoprotein 1"
4183:
4178:
4168:
4158:
4153:
4148:
4103:
4093:
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2754:
2690:
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2555:
2550:
2540:
2535:
2488:
2483:
2478:
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2421:
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2401:
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2354:
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2300:
2268:
2263:
2258:
2241:
2236:
2231:
2226:
1048:
832:
3695:
2307:
2295:
2290:
2285:
2275:
2248:
2216:
2091:"DNA cloning using in vitro site-specific recombination"
1970:
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1900:
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1502:
2029:
1452:
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1667:
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2089:Hartley JL, Temple GF, Brasch MA (November 2000).
2000:
984:
982:
980:
1106:
166:
4201:
1564:
1361:Waterhouse R, Ha C, Dveksler GS (January 2002).
1871:
1819:Khan WN, Osterman A, Hammarström S (May 1989).
977:
2178:
1290:
1286:
1284:
1206:
1204:
1210:
1901:Zimmermann W, Weiss M, Thompson JA (1989).
1102:
1100:
1098:
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989:GRCh38: Ensembl release 89: ENSG00000231924
2185:
2171:
2153:United States National Library of Medicine
1403:
1354:
1281:
1245:
1201:
1044:
1042:
1040:
1038:
1036:
2202:list of human clusters of differentiation
2142:at the U.S. National Library of Medicine
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2151:This article incorporates text from the
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1150:
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1146:
1093:
1021:
1019:
809:Pregnancy-specific beta-1-glycoprotein 1
1560:
1558:
1033:
819:(Cluster of Differentiation 66f), is a
27:Mammalian protein found in Homo sapiens
14:
4202:
1446:
2166:
1565:Pihl K, Christiansen M (March 2010).
1319:
1211:Watanabe S, Chou JY (February 1988).
1143:
1016:
171:
130:
125:
1555:
1496:
858:(Ig) superfamily and contains four
24:
1602:
25:
4226:
2133:
823:that in humans is encoded by the
364:
357:
350:
155:
148:
142:
117:
942:
998:
843:to protect the growing fetus.
375:More reference expression data
330:More reference expression data
13:
1:
2032:Biochem. Biophys. Res. Commun
1907:Biochem. Biophys. Res. Commun
1874:Biochem. Biophys. Res. Commun
1782:Biochem. Biophys. Res. Commun
1699:Biochem. Biophys. Res. Commun
1255:Biochem. Biophys. Res. Commun
1230:10.1016/S0021-9258(19)77983-6
971:
929:
140:
4210:Genes on human chromosome 19
2074:10.1016/0143-4004(77)90002-9
2015:10.1016/0378-1119(88)90061-3
1919:10.1016/0006-291X(89)91105-4
1886:10.1016/0006-291X(89)92631-4
1825:Proc. Natl. Acad. Sci. U.S.A
1804:10.1016/0006-291X(89)92821-0
1732:Proc. Natl. Acad. Sci. U.S.A
1711:10.1016/0006-291X(90)91455-2
1653:10.1016/0888-7543(90)90492-D
1624:10.1016/0888-7543(92)90309-G
1584:10.1373/clinchem.2009.135970
1509:Proc. Natl. Acad. Sci. U.S.A
1267:10.1016/0006-291X(88)90660-2
897:
849:
827:gene and is a member of the
7:
4215:Clusters of differentiation
2198:clusters of differentiation
1340:10.1095/biolreprod61.4.1056
959:
920:
273:stromal cell of endometrium
10:
4231:
1293:Seminars in Cancer Biology
966:Cluster of differentiation
4001:
3795:
3544:
3228:
2951:
2611:
2209:
1006:"Human PubMed Reference:"
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2144:Medical Subject Headings
1986:10.1089/dna.1.1988.7.545
1530:10.1073/pnas.92.26.12095
911:carcinoembryonic antigen
829:carcinoembryonic antigen
752:Chr 19: 42.87 – 42.88 Mb
1753:10.1073/pnas.87.15.5822
1176:10.1074/jbc.M110.161810
854:PSG is a member of the
2044:10.1006/bbrc.1995.1862
1846:10.1073/pnas.86.9.3332
1305:10.1006/scbi.1998.0119
875:Cell surface receptors
860:immunoglobulin domains
285:pancreatic ductal cell
1068:10.1186/1471-2164-6-4
133:Chromosome 19 (human)
1474:10.1189/jlb.72.3.512
1379:10.1084/jem.20011741
424:extracellular region
2140:PSG1+protein,+human
1837:1989PNAS...86.3332K
1744:1990PNAS...87.5822L
1682:10.1021/bi00463a030
1521:1995PNAS...9212095C
904:syncytiotrophoblast
445:leukocyte migration
2155:, which is in the
1948:10.1007/BF00291162
1424:10.1007/bf01927624
433:Biological process
417:Cellular component
401:Molecular function
297:lower lobe of lung
265:buccal mucosa cell
4197:
4196:
2107:10.1101/gr.143000
1109:Nat. Rev. Immunol
892:glycosaminoglycan
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805:
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336:
335:
323:
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16:(Redirected from
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1997:
1967:
1930:
1913:(3): 1197–1209.
1897:
1868:
1858:
1848:
1815:
1797:
1775:
1765:
1755:
1722:
1693:
1664:
1635:
1597:
1596:
1586:
1562:
1553:
1552:
1542:
1532:
1500:
1494:
1493:
1459:
1450:
1444:
1443:
1418:(9): 1197–1199.
1407:
1401:
1400:
1390:
1358:
1352:
1351:
1323:
1317:
1316:
1288:
1279:
1278:
1249:
1243:
1242:
1232:
1208:
1199:
1198:
1188:
1178:
1154:
1141:
1140:
1104:
1091:
1090:
1080:
1070:
1046:
1031:
1030:
1023:
1014:
1013:
1002:
996:
986:
815:) also known as
791:
790:
774:
759:
754:
737:
727:
726:
718:
690:
689:
686:RefSeq (protein)
676:
666:
665:
657:
629:
628:
607:
606:
588:
587:
564:
563:
545:
544:
521:
520:
502:
501:
471:
470:
440:female pregnancy
391:
390:
377:
368:
361:
354:
347:
346:
332:
308:
307:
289:secondary oocyte
253:
251:Top expressed in
246:
245:
225:
224:
208:
207:
198:
185:
174:
159:
152:
146:
135:
121:
105:
104:
99:
97:PSG1 - orthologs
58:
51:
30:
29:
21:
4230:
4229:
4225:
4224:
4223:
4221:
4220:
4219:
4200:
4199:
4198:
4193:
3997:
3791:
3540:
3224:
2947:
2607:
2205:
2191:
2136:
2131:
2101:(11): 1788–95.
1795:10.1.1.657.2780
1788:(3): 996–1004.
1676:(11): 2845–52.
1605:
1603:Further reading
1600:
1563:
1556:
1515:(26): 12095–9.
1501:
1497:
1462:J. Leukoc. Biol
1457:
1451:
1447:
1408:
1404:
1359:
1355:
1324:
1320:
1289:
1282:
1250:
1246:
1209:
1202:
1155:
1144:
1121:10.1038/nri1864
1105:
1094:
1047:
1034:
1025:
1024:
1017:
1004:
1003:
999:
987:
978:
974:
962:
945:
932:
923:
900:
879:dendritic cells
852:
846:
841:immunomodulator
795:View/Edit Human
772:
757:
750:
747:Location (UCSC)
735:
714:
710:
706:
702:
698:
674:
653:
649:
645:
641:
637:
554:ENSG00000231924
449:
428:
412:
408:protein binding
373:
363:
362:
356:
355:
328:
319:
300:
295:
291:
287:
283:
279:
275:
271:
267:
263:
249:
193:
180:
172:
162:
161:
160:
153:
131:
108:Gene location (
67:
54:
47:
28:
23:
22:
15:
12:
11:
5:
4228:
4218:
4217:
4212:
4195:
4194:
4192:
4191:
4186:
4181:
4176:
4171:
4166:
4161:
4156:
4151:
4146:
4141:
4136:
4131:
4126:
4121:
4116:
4111:
4106:
4101:
4096:
4091:
4086:
4081:
4076:
4071:
4066:
4061:
4056:
4051:
4046:
4041:
4036:
4031:
4026:
4021:
4016:
4011:
4005:
4003:
3999:
3998:
3996:
3995:
3990:
3985:
3980:
3975:
3970:
3965:
3960:
3955:
3950:
3945:
3940:
3935:
3930:
3925:
3920:
3915:
3910:
3905:
3900:
3895:
3890:
3885:
3880:
3875:
3870:
3865:
3860:
3855:
3850:
3845:
3840:
3835:
3830:
3825:
3820:
3815:
3810:
3805:
3799:
3797:
3793:
3792:
3790:
3789:
3784:
3775:
3770:
3765:
3760:
3755:
3750:
3745:
3740:
3735:
3730:
3729:
3728:
3723:
3713:
3708:
3703:
3698:
3693:
3688:
3683:
3678:
3673:
3668:
3663:
3658:
3653:
3648:
3642:
3633:
3628:
3627:
3626:
3621:
3611:
3606:
3605:
3604:
3599:
3589:
3584:
3579:
3574:
3569:
3564:
3559:
3554:
3548:
3546:
3542:
3541:
3539:
3538:
3533:
3528:
3523:
3518:
3513:
3508:
3503:
3498:
3493:
3488:
3483:
3478:
3473:
3468:
3463:
3458:
3453:
3452:
3451:
3446:
3436:
3431:
3426:
3421:
3420:
3419:
3414:
3409:
3399:
3394:
3389:
3384:
3379:
3378:
3377:
3372:
3362:
3357:
3352:
3347:
3342:
3337:
3332:
3331:
3330:
3325:
3315:
3309:
3304:
3299:
3294:
3285:
3280:
3279:
3278:
3273:
3268:
3258:
3253:
3248:
3243:
3238:
3232:
3230:
3226:
3225:
3223:
3222:
3217:
3212:
3207:
3202:
3197:
3192:
3187:
3182:
3177:
3172:
3167:
3162:
3157:
3152:
3147:
3142:
3137:
3132:
3127:
3122:
3117:
3112:
3107:
3102:
3097:
3096:
3095:
3090:
3080:
3079:
3078:
3073:
3063:
3058:
3053:
3048:
3043:
3038:
3033:
3028:
3023:
3018:
3013:
3008:
3003:
3002:
3001:
2996:
2986:
2981:
2976:
2971:
2966:
2961:
2955:
2953:
2949:
2948:
2946:
2945:
2940:
2935:
2930:
2925:
2920:
2915:
2910:
2905:
2896:
2891:
2886:
2881:
2876:
2871:
2870:
2869:
2864:
2859:
2854:
2849:
2844:
2834:
2829:
2824:
2819:
2814:
2809:
2808:
2807:
2802:
2792:
2787:
2782:
2777:
2772:
2767:
2762:
2757:
2752:
2751:
2750:
2745:
2740:
2735:
2730:
2725:
2715:
2714:
2713:
2708:
2703:
2693:
2688:
2687:
2686:
2681:
2676:
2666:
2661:
2656:
2651:
2646:
2641:
2636:
2631:
2626:
2621:
2615:
2613:
2609:
2608:
2606:
2605:
2600:
2599:
2598:
2593:
2588:
2583:
2578:
2573:
2563:
2558:
2553:
2548:
2543:
2538:
2533:
2532:
2531:
2526:
2521:
2516:
2506:
2501:
2496:
2491:
2486:
2481:
2476:
2471:
2466:
2461:
2460:
2459:
2454:
2444:
2439:
2434:
2429:
2424:
2419:
2414:
2409:
2404:
2399:
2394:
2389:
2384:
2379:
2374:
2373:
2372:
2367:
2357:
2352:
2347:
2342:
2341:
2340:
2335:
2330:
2325:
2315:
2310:
2305:
2304:
2303:
2293:
2288:
2283:
2278:
2273:
2272:
2271:
2266:
2261:
2251:
2246:
2245:
2244:
2239:
2234:
2229:
2224:
2213:
2211:
2207:
2206:
2190:
2189:
2182:
2175:
2167:
2148:
2147:
2135:
2134:External links
2132:
2130:
2129:
2086:
2068:(7): 491–501.
2056:
2038:(2): 656–664.
2027:
2009:(2): 439–449.
1998:
1968:
1942:(3): 239–243.
1931:
1898:
1880:(2): 525–535.
1869:
1816:
1776:
1738:(15): 5822–6.
1723:
1694:
1665:
1636:
1618:(4): 780–787.
1606:
1604:
1601:
1599:
1598:
1554:
1495:
1445:
1402:
1353:
1334:(4): 1056–61.
1318:
1280:
1244:
1223:(4): 2049–54.
1200:
1169:(9): 7577–86.
1142:
1092:
1032:
1015:
997:
975:
973:
970:
969:
968:
961:
958:
944:
941:
931:
928:
922:
919:
899:
896:
856:immunoglobulin
851:
848:
804:
803:
800:
799:
797:
787:
786:
780:
779:
776:
775:
770:
768:
761:
760:
755:
748:
744:
743:
740:
739:
731:
730:
724:
721:
720:
694:
693:
687:
683:
682:
679:
678:
670:
669:
663:
660:
659:
633:
632:
626:
622:
621:
618:
617:
611:
610:
604:
601:
600:
592:
591:
585:
579:
578:
575:
574:
568:
567:
561:
558:
557:
549:
548:
542:
536:
535:
532:
531:
525:
524:
518:
515:
514:
506:
505:
499:
493:
492:
487:
482:
478:
477:
467:
466:
463:
462:
451:
450:
448:
447:
442:
436:
434:
430:
429:
427:
426:
420:
418:
414:
413:
411:
410:
404:
402:
398:
397:
387:
386:
383:
382:
379:
378:
370:
369:
344:
338:
337:
334:
333:
325:
324:
321:
320:
318:
315:
312:
311:
305:
302:
301:
299:
298:
294:
290:
286:
282:
278:
277:amniotic fluid
274:
270:
266:
262:
258:
255:
254:
242:
241:
233:
222:
216:
215:
212:RNA expression
204:
203:
200:
199:
191:
187:
186:
178:
175:
170:
164:
163:
154:
147:
141:
137:
136:
129:
123:
122:
114:
113:
101:
100:
65:
61:
60:
52:
44:
43:
39:
38:
35:
34:
26:
9:
6:
4:
3:
2:
4227:
4216:
4213:
4211:
4208:
4207:
4205:
4190:
4187:
4185:
4182:
4180:
4177:
4175:
4172:
4170:
4167:
4165:
4162:
4160:
4157:
4155:
4152:
4150:
4147:
4145:
4142:
4140:
4137:
4135:
4132:
4130:
4127:
4125:
4122:
4120:
4117:
4115:
4112:
4110:
4107:
4105:
4102:
4100:
4097:
4095:
4092:
4090:
4087:
4085:
4082:
4080:
4077:
4075:
4072:
4070:
4067:
4065:
4062:
4060:
4057:
4055:
4052:
4050:
4047:
4045:
4042:
4040:
4037:
4035:
4032:
4030:
4027:
4025:
4022:
4020:
4017:
4015:
4012:
4010:
4007:
4006:
4004:
4000:
3994:
3991:
3989:
3986:
3984:
3981:
3979:
3976:
3974:
3971:
3969:
3966:
3964:
3961:
3959:
3956:
3954:
3951:
3949:
3946:
3944:
3941:
3939:
3936:
3934:
3931:
3929:
3926:
3924:
3921:
3919:
3916:
3914:
3911:
3909:
3906:
3904:
3901:
3899:
3896:
3894:
3891:
3889:
3886:
3884:
3881:
3879:
3876:
3874:
3871:
3869:
3866:
3864:
3861:
3859:
3856:
3854:
3851:
3849:
3846:
3844:
3841:
3839:
3836:
3834:
3831:
3829:
3826:
3824:
3821:
3819:
3816:
3814:
3811:
3809:
3806:
3804:
3801:
3800:
3798:
3794:
3788:
3785:
3783:
3779:
3776:
3774:
3771:
3769:
3766:
3764:
3761:
3759:
3756:
3754:
3751:
3749:
3746:
3744:
3741:
3739:
3736:
3734:
3731:
3727:
3724:
3722:
3719:
3718:
3717:
3714:
3712:
3709:
3707:
3704:
3702:
3699:
3697:
3694:
3692:
3689:
3687:
3684:
3682:
3679:
3677:
3674:
3672:
3669:
3667:
3664:
3662:
3659:
3657:
3654:
3652:
3649:
3646:
3643:
3641:
3637:
3634:
3632:
3629:
3625:
3622:
3620:
3617:
3616:
3615:
3612:
3610:
3607:
3603:
3600:
3598:
3595:
3594:
3593:
3590:
3588:
3585:
3583:
3580:
3578:
3575:
3573:
3570:
3568:
3565:
3563:
3560:
3558:
3555:
3553:
3550:
3549:
3547:
3543:
3537:
3534:
3532:
3529:
3527:
3524:
3522:
3519:
3517:
3514:
3512:
3509:
3507:
3504:
3502:
3499:
3497:
3494:
3492:
3489:
3487:
3484:
3482:
3479:
3477:
3474:
3472:
3469:
3467:
3464:
3462:
3459:
3457:
3454:
3450:
3447:
3445:
3442:
3441:
3440:
3437:
3435:
3432:
3430:
3427:
3425:
3422:
3418:
3415:
3413:
3410:
3408:
3405:
3404:
3403:
3400:
3398:
3395:
3393:
3390:
3388:
3385:
3383:
3380:
3376:
3373:
3371:
3368:
3367:
3366:
3363:
3361:
3358:
3356:
3353:
3351:
3348:
3346:
3343:
3341:
3338:
3336:
3333:
3329:
3326:
3324:
3321:
3320:
3319:
3316:
3313:
3310:
3308:
3305:
3303:
3300:
3298:
3295:
3293:
3289:
3286:
3284:
3281:
3277:
3274:
3272:
3269:
3267:
3264:
3263:
3262:
3259:
3257:
3254:
3252:
3249:
3247:
3244:
3242:
3239:
3237:
3234:
3233:
3231:
3227:
3221:
3218:
3216:
3213:
3211:
3208:
3206:
3203:
3201:
3198:
3196:
3193:
3191:
3188:
3186:
3183:
3181:
3178:
3176:
3173:
3171:
3168:
3166:
3163:
3161:
3158:
3156:
3153:
3151:
3148:
3146:
3143:
3141:
3138:
3136:
3133:
3131:
3128:
3126:
3123:
3121:
3118:
3116:
3113:
3111:
3108:
3106:
3103:
3101:
3098:
3094:
3091:
3089:
3086:
3085:
3084:
3081:
3077:
3074:
3072:
3069:
3068:
3067:
3064:
3062:
3059:
3057:
3054:
3052:
3049:
3047:
3044:
3042:
3039:
3037:
3034:
3032:
3029:
3027:
3024:
3022:
3019:
3017:
3014:
3012:
3009:
3007:
3004:
3000:
2997:
2995:
2992:
2991:
2990:
2987:
2985:
2982:
2980:
2977:
2975:
2972:
2970:
2967:
2965:
2962:
2960:
2957:
2956:
2954:
2950:
2944:
2941:
2939:
2936:
2934:
2931:
2929:
2926:
2924:
2921:
2919:
2916:
2914:
2911:
2909:
2906:
2904:
2900:
2897:
2895:
2892:
2890:
2887:
2885:
2882:
2880:
2877:
2875:
2872:
2868:
2865:
2863:
2860:
2858:
2855:
2853:
2850:
2848:
2845:
2843:
2840:
2839:
2838:
2835:
2833:
2830:
2828:
2825:
2823:
2820:
2818:
2815:
2813:
2810:
2806:
2803:
2801:
2798:
2797:
2796:
2793:
2791:
2788:
2786:
2783:
2781:
2778:
2776:
2773:
2771:
2768:
2766:
2763:
2761:
2758:
2756:
2753:
2749:
2746:
2744:
2741:
2739:
2736:
2734:
2731:
2729:
2726:
2724:
2721:
2720:
2719:
2716:
2712:
2709:
2707:
2704:
2702:
2699:
2698:
2697:
2694:
2692:
2689:
2685:
2682:
2680:
2677:
2675:
2672:
2671:
2670:
2667:
2665:
2662:
2660:
2657:
2655:
2652:
2650:
2647:
2645:
2642:
2640:
2637:
2635:
2632:
2630:
2627:
2625:
2622:
2620:
2617:
2616:
2614:
2610:
2604:
2601:
2597:
2594:
2592:
2589:
2587:
2584:
2582:
2579:
2577:
2574:
2572:
2569:
2568:
2567:
2564:
2562:
2559:
2557:
2554:
2552:
2549:
2547:
2544:
2542:
2539:
2537:
2534:
2530:
2527:
2525:
2522:
2520:
2517:
2515:
2512:
2511:
2510:
2507:
2505:
2502:
2500:
2497:
2495:
2492:
2490:
2487:
2485:
2482:
2480:
2477:
2475:
2472:
2470:
2467:
2465:
2462:
2458:
2455:
2453:
2450:
2449:
2448:
2445:
2443:
2440:
2438:
2435:
2433:
2430:
2428:
2425:
2423:
2420:
2418:
2415:
2413:
2410:
2408:
2405:
2403:
2400:
2398:
2395:
2393:
2390:
2388:
2385:
2383:
2380:
2378:
2375:
2371:
2368:
2366:
2363:
2362:
2361:
2358:
2356:
2353:
2351:
2348:
2346:
2343:
2339:
2336:
2334:
2331:
2329:
2326:
2324:
2321:
2320:
2319:
2316:
2314:
2311:
2309:
2306:
2302:
2299:
2298:
2297:
2294:
2292:
2289:
2287:
2284:
2282:
2279:
2277:
2274:
2270:
2267:
2265:
2262:
2260:
2257:
2256:
2255:
2252:
2250:
2247:
2243:
2240:
2238:
2235:
2233:
2230:
2228:
2225:
2223:
2220:
2219:
2218:
2215:
2214:
2212:
2208:
2203:
2199:
2195:
2188:
2183:
2181:
2176:
2174:
2169:
2168:
2165:
2161:
2160:
2158:
2157:public domain
2154:
2145:
2141:
2138:
2137:
2126:
2122:
2117:
2112:
2108:
2104:
2100:
2096:
2092:
2087:
2083:
2079:
2075:
2071:
2067:
2063:
2057:
2053:
2049:
2045:
2041:
2037:
2033:
2028:
2024:
2020:
2016:
2012:
2008:
2004:
1999:
1995:
1991:
1987:
1983:
1980:(8): 545–55.
1979:
1975:
1969:
1965:
1961:
1957:
1953:
1949:
1945:
1941:
1937:
1932:
1928:
1924:
1920:
1916:
1912:
1908:
1904:
1899:
1895:
1891:
1887:
1883:
1879:
1875:
1870:
1866:
1862:
1857:
1852:
1847:
1842:
1838:
1834:
1831:(9): 3332–6.
1830:
1826:
1822:
1817:
1813:
1809:
1805:
1801:
1796:
1791:
1787:
1783:
1777:
1773:
1769:
1764:
1759:
1754:
1749:
1745:
1741:
1737:
1733:
1729:
1724:
1720:
1716:
1712:
1708:
1705:(1): 203–16.
1704:
1700:
1695:
1691:
1687:
1683:
1679:
1675:
1671:
1666:
1662:
1658:
1654:
1650:
1647:(4): 579–92.
1646:
1642:
1637:
1633:
1629:
1625:
1621:
1617:
1613:
1608:
1607:
1594:
1590:
1585:
1580:
1576:
1572:
1568:
1561:
1559:
1550:
1546:
1541:
1536:
1531:
1526:
1522:
1518:
1514:
1510:
1506:
1499:
1491:
1487:
1483:
1479:
1475:
1471:
1468:(3): 512–21.
1467:
1463:
1456:
1449:
1441:
1437:
1433:
1429:
1425:
1421:
1417:
1413:
1406:
1398:
1394:
1389:
1384:
1380:
1376:
1373:(2): 277–82.
1372:
1368:
1364:
1357:
1349:
1345:
1341:
1337:
1333:
1329:
1322:
1314:
1310:
1306:
1302:
1298:
1294:
1287:
1285:
1276:
1272:
1268:
1264:
1260:
1256:
1248:
1240:
1236:
1231:
1226:
1222:
1218:
1217:J. Biol. Chem
1214:
1207:
1205:
1196:
1192:
1187:
1182:
1177:
1172:
1168:
1164:
1163:J. Biol. Chem
1160:
1153:
1151:
1149:
1147:
1138:
1134:
1130:
1126:
1122:
1118:
1115:(6): 433–46.
1114:
1110:
1103:
1101:
1099:
1097:
1088:
1084:
1079:
1074:
1069:
1064:
1060:
1056:
1052:
1045:
1043:
1041:
1039:
1037:
1028:
1022:
1020:
1011:
1007:
1001:
994:
990:
985:
983:
981:
976:
967:
964:
963:
957:
953:
951:
950:Down syndrome
940:
936:
927:
918:
914:
912:
907:
905:
895:
893:
889:
884:
880:
876:
872:
867:
863:
861:
857:
847:
844:
842:
838:
834:
830:
826:
822:
818:
814:
810:
796:
792:
788:
785:
781:
771:
769:
766:
762:
756:
753:
749:
745:
738:
732:
728:
725:
719:
717:
713:
709:
705:
701:
695:
691:
688:
684:
677:
671:
667:
664:
658:
656:
652:
648:
644:
640:
634:
630:
627:
625:RefSeq (mRNA)
623:
616:
612:
608:
605:
599:
598:
593:
589:
586:
584:
580:
573:
569:
565:
562:
556:
555:
550:
546:
543:
541:
537:
530:
526:
522:
519:
513:
512:
507:
503:
500:
498:
494:
491:
488:
486:
483:
479:
476:
472:
468:
461:
457:
452:
446:
443:
441:
438:
437:
435:
432:
431:
425:
422:
421:
419:
416:
415:
409:
406:
405:
403:
400:
399:
396:
395:Gene ontology
392:
388:
376:
371:
367:
360:
353:
348:
345:
343:
339:
331:
326:
316:
313:
309:
306:
296:
292:
288:
284:
280:
276:
272:
268:
264:
260:
259:
256:
252:
247:
244:
243:
240:
238:
234:
232:
231:
227:
226:
223:
221:
217:
213:
209:
205:
197:
192:
188:
184:
179:
169:
165:
158:
151:
145:
138:
134:
128:
124:
120:
115:
111:
106:
102:
98:
94:
90:
86:
82:
78:
74:
70:
62:
57:
50:
45:
40:
36:
31:
19:
3715:
3635:
3613:
3591:
3438:
3401:
3364:
3317:
3287:
3260:
3082:
2988:
2836:
2565:
2317:
2150:
2149:
2098:
2094:
2065:
2061:
2035:
2031:
2006:
2002:
1977:
1973:
1939:
1935:
1910:
1906:
1877:
1873:
1828:
1824:
1785:
1781:
1735:
1731:
1702:
1698:
1673:
1670:Biochemistry
1669:
1644:
1640:
1615:
1611:
1577:(3): 485–7.
1574:
1570:
1512:
1508:
1498:
1465:
1461:
1448:
1415:
1411:
1405:
1370:
1366:
1356:
1331:
1328:Biol. Reprod
1327:
1321:
1299:(2): 67–81.
1296:
1292:
1261:(1): 130–7.
1258:
1254:
1247:
1220:
1216:
1166:
1162:
1112:
1108:
1058:
1055:BMC Genomics
1054:
1009:
1000:
954:
946:
943:Applications
937:
933:
924:
915:
908:
901:
888:proteoglycan
868:
864:
853:
845:
837:glycoprotein
824:
816:
812:
808:
807:
734:
712:NP_001317453
708:NP_001284702
704:NP_001171755
700:NP_001171754
697:
673:
655:NM_001330524
647:NM_001297773
643:NM_001184826
639:NM_001184825
636:
614:
595:
571:
552:
528:
509:
489:
484:
235:
228:
64:External IDs
1412:Experientia
1367:J. Exp. Med
293:skin of hip
194:42,879,822
181:42,866,464
42:Identifiers
18:PSG1 (gene)
4204:Categories
2200:(see also
2095:Genome Res
1936:Hum. Genet
1571:Clin. Chem
995:, May 2017
972:References
930:Inhibitors
883:epithelial
239:(ortholog)
77:HomoloGene
1790:CiteSeerX
898:Formation
871:receptors
850:Structure
716:NP_008836
651:NM_006905
475:Orthologs
85:GeneCards
2194:Proteins
2125:11076863
2062:Placenta
1964:26795108
1641:Genomics
1612:Genomics
1593:19959618
1490:11774170
1482:12223519
1440:43539581
1397:11805154
1348:10491644
1313:10202129
1195:21193412
1137:34156579
1129:16724098
1087:15647114
991:–
960:See also
921:Function
784:Wikidata
454:Sources:
269:testicle
261:placenta
4002:301–350
3796:251–300
3748:CD240CE
3545:201–250
3229:151–200
2952:101–150
2082:9290143
2052:7794280
2023:3265688
1994:3180995
1956:2786492
1927:2783133
1894:2735907
1865:2541441
1833:Bibcode
1812:2537643
1772:2377620
1740:Bibcode
1719:2350345
1690:2346748
1661:2341148
1632:1572651
1549:8618851
1517:Bibcode
1388:2193606
1275:3260773
1239:3257488
1186:3045012
993:Ensembl
821:protein
583:UniProt
540:Ensembl
481:Species
460:QuickGO
214:pattern
173:19q13.2
49:Aliases
4009:CD300A
3968:CDw293
3753:CD240D
3614:CD213a
3592:CDw210
3557:CD202b
3531:CDw199
3526:CDw198
3180:CD140b
2612:51–100
2146:(MeSH)
2123:
2116:310948
2113:
2080:
2050:
2021:
1992:
1962:
1954:
1925:
1892:
1863:
1856:287126
1853:
1810:
1792:
1770:
1760:
1717:
1688:
1659:
1630:
1591:
1547:
1537:
1488:
1480:
1438:
1432:971765
1430:
1395:
1385:
1346:
1311:
1273:
1237:
1193:
1183:
1135:
1127:
1085:
1078:546212
1075:
869:While
831:(CEA)
813:PSBG-1
767:search
765:PubMed
597:P11464
497:Entrez
342:BioGPS
81:136364
73:176390
4189:CD350
4184:CD349
4179:CD344
4174:CD340
4169:CD339
4164:CD338
4159:CD337
4154:CD336
4149:CD335
4144:CD334
4139:CD333
4134:CD332
4129:CD331
4124:CD329
4119:CD328
4114:CD327
4109:CD326
4104:CD325
4099:CD324
4094:CD322
4089:CD321
4084:CD320
4079:CD318
4074:CD317
4069:CD316
4064:CD315
4059:CD314
4054:CD312
4049:CD309
4044:CD307
4039:CD306
4034:CD305
4029:CD304
4024:CD303
4019:CD302
4014:CD301
3993:CD299
3988:CD298
3983:CD297
3978:CD295
3973:CD294
3963:CD292
3958:CD290
3953:CD289
3948:CD288
3943:CD286
3938:CD284
3933:CD283
3928:CD282
3923:CD281
3918:CD280
3913:CD279
3908:CD278
3903:CD276
3898:CD275
3893:CD274
3888:CD273
3883:CD272
3878:CD271
3873:CD269
3868:CD268
3863:CD267
3858:CD266
3853:CD265
3848:CD264
3843:CD263
3838:CD262
3833:CD261
3828:CD258
3823:CD257
3818:CD256
3813:CD254
3808:CD253
3803:CD252
3787:CD249
3782:CD248
3778:CD247
3773:CD246
3768:CD244
3763:CD243
3758:CD241
3743:CD239
3738:CD238
3733:CD236
3716:CD235
3711:CD234
3706:CD233
3701:CD230
3696:CD229
3691:CD228
3686:CD227
3681:CD226
3676:CD225
3671:CD224
3666:CD223
3661:CD222
3656:CD221
3651:CD220
3636:CD218
3631:CD217
3609:CD212
3587:CD209
3582:CD208
3577:CD207
3572:CD206
3567:CD205
3562:CD204
3552:CD201
3536:CD200
3521:CD197
3516:CD196
3511:CD195
3506:CD194
3501:CD193
3496:CD192
3491:CD191
3486:CD186
3481:CD185
3476:CD184
3471:CD183
3466:CD182
3461:CD181
3456:CD180
3439:CD179
3434:CD178
3429:CD177
3424:CD174
3402:CD172
3397:CD171
3392:CD170
3387:CD169
3382:CD168
3365:CD167
3360:CD166
3355:CD164
3350:CD163
3345:CD162
3340:CD161
3335:CD160
3318:CD159
3288:CD158
3283:CD157
3261:CD156
3256:CD155
3251:CD154
3246:CD153
3241:CD152
3236:CD151
3220:CD150
3215:CD148
3210:CD147
3205:CD146
3200:CD144
3195:CD143
3190:CD142
3185:CD141
3175:CD138
3170:CD137
3165:CD136
3160:CD135
3155:CD134
3150:CD133
3145:CD132
3140:CD131
3135:CD130
3130:CD129
3125:CD127
3120:CD126
3115:CD125
3110:CD124
3105:CD123
3100:CD122
3083:CD121
3066:CD120
3061:CD119
3056:CD118
3051:CD117
3046:CD116
3041:CD115
3036:CD114
3031:CD113
3026:CD112
3021:CD111
3016:CD110
3011:CD109
3006:CD108
2989:CD107
2984:CD106
2979:CD105
2974:CD104
2969:CD103
2964:CD102
2959:CD101
2943:CD100
1960:S2CID
1763:54420
1540:40303
1486:S2CID
1458:(PDF)
1436:S2CID
1133:S2CID
1061:: 4.
817:CD66f
490:Mouse
485:Human
456:Amigo
281:gonad
237:Mouse
230:Human
177:Start
110:Human
2938:CD99
2933:CD98
2928:CD97
2923:CD96
2918:CD95
2913:CD94
2908:CD93
2903:CD92
2899:CD91
2894:CD90
2889:CD89
2884:CD88
2879:CD87
2874:CD86
2837:CD85
2832:CD84
2827:CD83
2822:CD82
2817:CD81
2812:CD80
2795:CD79
2790:CD78
2785:CD74
2780:CD73
2775:CD72
2770:CD71
2765:CD70
2760:CD69
2755:CD68
2718:CD66
2696:CD64
2691:CD63
2669:CD62
2664:CD61
2659:CD59
2654:CD58
2649:CD57
2644:CD56
2639:CD55
2634:CD54
2629:CD53
2624:CD52
2619:CD51
2603:CD50
2566:CD49
2561:CD48
2556:CD47
2551:CD46
2546:CD45
2541:CD44
2536:CD43
2509:CD42
2504:CD41
2499:CD40
2494:CD39
2489:CD38
2484:CD37
2479:CD36
2474:CD35
2469:CD34
2464:CD33
2447:CD32
2442:CD31
2437:CD30
2432:CD29
2427:CD28
2422:CD27
2417:CD26
2412:CD25
2407:CD24
2402:CD23
2397:CD22
2392:CD21
2387:CD20
2382:CD19
2377:CD18
2360:CD16
2355:CD15
2350:CD14
2345:CD13
2318:CD11
2313:CD10
2210:1–50
2121:PMID
2078:PMID
2048:PMID
2019:PMID
2003:Gene
1990:PMID
1952:PMID
1923:PMID
1890:PMID
1861:PMID
1808:PMID
1768:PMID
1715:PMID
1686:PMID
1657:PMID
1628:PMID
1589:PMID
1545:PMID
1478:PMID
1428:PMID
1393:PMID
1344:PMID
1309:PMID
1271:PMID
1235:PMID
1191:PMID
1125:PMID
1083:PMID
881:and
833:gene
825:PSG1
511:5669
220:Bgee
168:Band
127:Chr.
89:PSG1
69:OMIM
56:PSG1
33:PSG1
2308:CD9
2296:CD8
2291:CD7
2286:CD6
2281:CD5
2276:CD4
2254:CD3
2249:CD2
2222:a-c
2217:CD1
2111:PMC
2103:doi
2070:doi
2040:doi
2036:211
2011:doi
1982:doi
1974:DNA
1944:doi
1915:doi
1911:163
1882:doi
1878:161
1851:PMC
1841:doi
1800:doi
1786:158
1758:PMC
1748:doi
1707:doi
1703:169
1678:doi
1649:doi
1620:doi
1579:doi
1535:PMC
1525:doi
1470:doi
1420:doi
1383:PMC
1375:doi
1371:195
1336:doi
1301:doi
1263:doi
1259:154
1225:doi
1221:263
1181:PMC
1171:doi
1167:286
1117:doi
1073:PMC
1063:doi
773:n/a
758:n/a
736:n/a
675:n/a
615:n/a
572:n/a
529:n/a
317:n/a
190:End
93:OMA
4206::
3780:-
2901:-
2242:1E
2237:1D
2232:1B
2227:1A
2196::
2119:.
2109:.
2099:10
2097:.
2093:.
2076:.
2066:18
2064:.
2046:.
2034:.
2017:.
2007:71
2005:.
1988:.
1976:.
1958:.
1950:.
1940:82
1938:.
1921:.
1909:.
1905:.
1888:.
1876:.
1859:.
1849:.
1839:.
1829:86
1827:.
1823:.
1806:.
1798:.
1784:.
1766:.
1756:.
1746:.
1736:87
1734:.
1730:.
1713:.
1701:.
1684:.
1674:29
1672:.
1655:.
1643:.
1626:.
1616:12
1614:.
1587:.
1575:56
1573:.
1569:.
1557:^
1543:.
1533:.
1523:.
1513:92
1511:.
1507:.
1484:.
1476:.
1466:72
1464:.
1460:.
1434:.
1426:.
1416:32
1414:.
1391:.
1381:.
1369:.
1365:.
1342:.
1332:61
1330:.
1307:.
1295:.
1283:^
1269:.
1257:.
1233:.
1219:.
1215:.
1203:^
1189:.
1179:.
1165:.
1161:.
1145:^
1131:.
1123:.
1111:.
1095:^
1081:.
1071:.
1057:.
1053:.
1035:^
1018:^
1008:.
979:^
952:.
862:.
458:/
196:bp
183:bp
91:;
87::
83:;
79::
75:;
71::
3726:b
3721:a
3647:)
3645:b
3640:a
3638:(
3624:2
3619:1
3602:b
3597:a
3449:b
3444:a
3417:g
3412:b
3407:a
3375:b
3370:a
3328:c
3323:a
3314:)
3312:k
3307:i
3302:e
3297:d
3292:a
3290:(
3276:c
3271:b
3266:a
3093:b
3088:a
3076:b
3071:a
2999:b
2994:a
2867:k
2862:j
2857:h
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