184:). Author or coauthor of many scientific research publications, he is also coauthor of a widely used 3-volume textbook on biophysical chemistry. His research interests have focused on aminoacyl tRNA synthetases as fundamental interpreters of the genetic information. Through career-long investigations of this ancient and universal set of essential enzymes, his laboratory has worked on a universal mechanism for correcting errors in the interpretation of genetic information, and went on to show how this mechanism is essential for maintaining cellular homeostasis and for preventing serious pathologies and disease. He has also been listed as one of the leading translational researchers in the world, having one of the top five most cited patents for the period 2012-2016.
188:(expressed sequence tags) and the strategy of shotgun sequencing, approaches that several years later were adopted for the human genome project. Nature magazine listed Schimmel's work on the development of ESTs as one of the four key developments that launched the human genome project. Lastly, his laboratory established connections of synthetases to disease and, most recently, they reported the structural and functional metamorphosis of these proteins, whereby they are repurposed with novel activities, both inside and outside the cell, in a variety of cell signaling pathways
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Inventors. Active in many scientific and academic organizations and committees, including past service as
President of the Division of Biological Chemistry of the American Chemical Society (presently with over 7,000 members) and as an editorial board member of numerous scientific journals. In June 2020, he was named the 2020 winner of the
187:
His laboratory also discovered what others have referred to as a tRNA synthetase-directed primordial, or 'second', genetic code that eventually was incorporated into the modern code. In a separate line of research published back in 1983, Schimmel developed the concept of what are now known as ESTs
196:
Named to various society and university awards and honorary degrees, and elected to membership in the
American Academy of Arts and Sciences, the National Academy of Sciences, the American Philosophical Society, the Institute of Medicine (National Academy of Medicine) and National Academy of
421:
Lee, Jeong Woong; Beebe, Kirk; Nangle, Leslie A.; Jang, Jaeseon; Longo-Guess, Chantal M.; Cook, Susan A.; Davisson, Muriel T.; Sundberg, John P.; Schimmel, Paul (September 7, 2006). "Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration".
282:"Biophysical Chemistry Part I: The Conformation of Biological Macromolecules, Biophysical Chemistry Part II: Techniques for the Study of Biological Structure and Function, Biophysical Chemistry Part III: The Behavior of Biological Macromolecules"
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Award for
Entrepreneurial Success for "co-founding more than ten biotech companies and aiding others in their endeavors for nearly three decades." Named the ARCS San Diego Chapter 2020 Scientist of the Year
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Song, Youngzee; Zhou, Huihao; Vo, My-Nuong; Shi, Yi; Nawaz, Mir
Hussain; Vargas-Rodriguez, Oscar; Diedrich, Jolene K.; Yates, John R.; Kishi, Shuji (December 22, 2017).
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Lo, Wing-Sze; Gardiner, Elisabeth; Xu, Zhiwen; Lau, Ching-Fun; Wang, Feng; Zhou, Jie J.; Mendlein, John D.; Nangle, Leslie A.; Chiang, Kyle P. (July 18, 2014).
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Putney, S. D.; Herlihy, W. C.; Schimmel, P. (April 21, 1983). "A new troponin T and cDNA clones for 13 different muscle proteins, found by shotgun sequencing".
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Institute. Prior to joining The
Scripps Research Institute, he was a John D. and Catherine T. MacArthur Professor of Biochemistry and Biophysics at MIT (
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Francklyn, C.; Shi, J. P.; Schimmel, P. (February 28, 1992). "Overlapping nucleotide determinants for specific aminoacylation of RNA microhelices".
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Lander, E. S.; Linton, L. M.; Birren, B.; Nusbaum, C.; Zody, M. C.; Baldwin, J.; Devon, K.; Dewar, K.; Doyle, M. (February 15, 2001).
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181:
90:
221:
Who's who in the West: A Biographical
Dictionary of Noteworthy Men and Women of the Pacific Coast and the Western States
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Schmidt, E.; Schimmel, P. (April 8, 1994). "Mutational isolation of a sieve for editing in a transfer RNA synthetase".
705:
Schimmel, Paul (January 2018). "The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis".
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Liu, Ye; Satz, Jakob S.; Vo, My-Nuong; Nangle, Leslie A.; Schimmel, Paul; Ackerman, Susan L. (December 9, 2014).
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366:"Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid"
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Francklyn, C.; Schimmel, P. (February 2, 1989). "Aminoacylation of RNA minihelices with alanine".
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168:(born August 4, 1940) is an American biophysical chemist and translational medicine pioneer.
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918:"A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol"
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Proceedings of the
National Academy of Sciences of the United States of America
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483:"Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy"
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Emily M. Gray Award for
Significant Contributions to Education in Biophysics
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975:"Human tRNA synthetase catalytic nulls with diverse functions"
869:"Essential nontranslational functions of tRNA synthetases"
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Paul
Schimmel is a Professor of Molecular Medicine at The
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Members of the United States
National Academy of Sciences
814:
817:"Initial sequencing and analysis of the human genome"
755:
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Huggett, Brady; Paisner, Kathryn (December 1, 2017).
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267:"Complete List of Published Work in MyBibliography"
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916:Sajish, Mathew; Schimmel, Paul (March 19, 2015).
594:
119:Kathryn C. Hach Award for Entrepreneurial Success
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1126:"ARCS 2020 Scientist of the Year | San Diego"
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115:Stein and Moore Award of the Protein Society
1736:Members of the National Academy of Medicine
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1101:"2020 National Award Recipients Citations"
542:"Top 20 translational researchers of 2016"
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1031:"American Academy of Arts and Sciences"
867:Guo, Min; Schimmel, Paul (March 2013).
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280:Cantor, Charles R.; Schimmel, Paul R.
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182:Massachusetts Institute of Technology
91:Massachusetts Institute of Technology
1215:Paul-Lewis Award in Enzyme Chemistry
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1205:Pfizer Award in Enzyme Chemistry
1059:"American Philosophical Society"
104:Pfizer Award in Enzyme Chemistry
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224:. A.N. Marquis Company. 2001.
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1169:Complete list of publications
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1130:san-diego.arcsfoundation.org
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1666:Mohammad Seyedsayamdost
1582:Wilfred A. van der Donk
999:10.1126/science.1252943
873:Nature Chemical Biology
676:10.1126/science.1546312
508:10.1073/pnas.1420196111
335:10.1126/science.8146659
23:Paul Schimmel (curator)
300:"Schimmel Lab Website"
166:Paul Reinhard Schimmel
1552:David W. Christianson
1398:Michael J. Chamberlin
885:10.1038/nchembio.1158
370:Nature Communications
21:For the curator, see
1570:Karin Musier-Forsyth
1386:Ekkehard K. F. Bautz
1340:Frederic M. Richards
1132:. September 28, 2020
546:Nature Biotechnology
1432:Frederik C. Hartman
1420:Stephen J. Benkovic
1414:Joseph L. Goldstein
1316:Frank M. Huennekens
1292:G. Robert Greenberg
1262:Bernard L. Horecker
1238:Albert L. Lehninger
991:2014Sci...345..328L
942:10.1038/nature14028
934:2015Natur.519..370S
770:1983Natur.302..718P
719:10.1038/nrm.2017.77
668:1992Sci...255.1121F
662:(5048): 1121–1125.
609:1989Natur.337..478F
499:2014PNAS..11117570L
493:(49): 17570–17575.
444:10.1038/nature05096
436:2006Natur.443...50L
382:2017NatCo...8.2281S
327:1994Sci...264..265S
253:"TSRI Faculty Page"
1492:Kenneth A. Johnson
1450:Richard R. Burgess
1334:Marshall Nirenberg
1322:Jack L. Strominger
286:Macmillan Learning
140:Molecular Medicine
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1588:Nicole S. Sampson
1534:P. Andrew Karplus
1462:Robert T.N. Tjian
1404:Malcolm L. Gefter
1374:Herbert Weissbach
1368:Robert T. Schimke
1362:William J. Rutter
1298:Eugene P. Kennedy
985:(6194): 328–332.
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146:Doctoral students
126:Scientific career
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1672:Kenichi Yokoyama
1648:Douglas Mitchell
1612:Virginia Cornish
1600:Neil L. Kelleher
1546:Ronald T. Raines
1540:Daniel Herschlag
1486:John W. Kozarich
1438:Thomas A. Steitz
1410:Michael S. Brown
1268:Earl R. Stadtman
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