985:
90:, which lowers arterial pressure. Thus, despite not being true antihistamines because they do not bind to and block the histamine receptor, epinephrine and other such substances are physiological antagonists to histamine.
108:
Pietrapiana, D; Sala, M; Prat, M; Sinigaglia, F (Aug 15, 2005). "Met identification on human platelets: role of hepatocyte growth factor in the modulation of platelet activation".
31:
describes the behavior of a substance that produces effects counteracting those of another substance (a result similar to that produced by an
19:
describes the action of a substance which ultimately produces the same effects in the body as another substance—as if they were both
1026:
169:
35:
blocking the action of an agonist at the same receptor) using a mechanism that does not involve binding to the same receptor.
955:
509:
945:
885:
378:
940:
636:
547:
413:
1000:
865:
490:
1045:
418:
1065:
608:
1060:
1019:
343:
162:
1050:
855:
603:
597:
920:
622:
57:
671:
433:
428:
338:
256:
24:
807:
568:
543:
478:
367:
251:
1012:
915:
707:
186:
155:
82:. For instance, epinephrine raises arterial pressure through vasoconstriction mediated by A1-
75:
950:
812:
722:
563:
443:
211:
71:
53:
8:
1055:
860:
748:
717:
363:
323:
246:
83:
32:
830:
780:
681:
494:
473:
373:
294:
206:
133:
79:
825:
686:
676:
504:
498:
333:
125:
137:
870:
758:
753:
553:
523:
309:
289:
271:
117:
20:
121:
910:
785:
613:
573:
558:
266:
216:
468:
996:
900:
880:
799:
641:
383:
328:
1039:
984:
905:
392:
299:
992:
875:
835:
736:
660:
538:
221:
178:
129:
960:
447:
423:
49:
840:
772:
664:
439:
107:
618:
87:
740:
712:
699:
388:
201:
147:
593:
486:
482:
284:
60:(HGF). Thus, they are physiological agonists to each other.
659:
933:
735:
893:
355:
317:
1037:
27:—without actually binding to the same receptor.
1020:
798:
163:
101:
64:
1027:
1013:
170:
156:
771:
239:
194:
43:
698:
406:
70:There are several substances that have
1038:
531:
461:
151:
979:
586:
13:
956:Minimum bactericidal concentration
14:
1077:
983:
946:Minimum inhibitory concentration
177:
886:WHO list of essential medicines
379:Non-specific effect of vaccines
941:Antimicrobial pharmacodynamics
1:
866:Functional analog (chemistry)
122:10.1016/j.febslet.2005.06.072
94:
999:. You can help Knowledge by
419:Hill equation (biochemistry)
7:
86:activation, in contrast to
38:
10:
1082:
978:
934:Antimicrobial pharmacology
414:Dose–response relationship
344:Desensitization (medicine)
856:Coinduction (anesthetics)
849:
650:
522:
308:
185:
74:action despite not being
65:Physiological antagonists
921:Multiple drug resistance
894:Tolerance and resistance
262:Physiological antagonist
58:hepatocyte growth factor
29:Physiological antagonism
672:Neuropsychopharmacology
434:Cheng-Prussoff Equation
429:Del Castillo Katz model
356:Other effects of ligand
339:Receptor (biochemistry)
257:Irreversible antagonist
808:Classical pharmacology
569:Plasma protein binding
544:Volume of distribution
252:Competitive antagonist
44:Physiological agonists
916:Antibiotic resistance
708:Clinical pharmacology
227:Physiological agonist
187:Ligand (biochemistry)
17:Physiological agonism
813:Reverse pharmacology
723:Pharmacoepidemiology
564:Biological half-life
444:Ligand binding assay
318:Activity at receptor
212:Irreversible agonist
54:platelet aggregation
1046:Medical terminology
861:Combination therapy
749:Pharmacoinformatics
718:Medicinal chemistry
324:Mechanism of action
84:adrenergic receptor
1066:Biochemistry stubs
831:Immunopharmacology
781:Pharmacotoxicology
682:Psychopharmacology
474:Intrinsic activity
374:Pleiotropy (drugs)
295:Agonist-antagonist
207:Endogenous agonist
80:histamine receptor
1061:Receptor agonists
1008:
1007:
973:
972:
969:
968:
929:
928:
826:Photopharmacology
821:
820:
794:
793:
767:
766:
731:
730:
694:
693:
687:Electrophysiology
677:Neuropharmacology
632:
631:
582:
581:
518:
517:
505:Therapeutic index
457:
456:
402:
401:
351:
350:
280:
279:
235:
234:
72:antihistaminergic
1073:
1051:Pharmacodynamics
1029:
1022:
1015:
987:
980:
931:
930:
891:
890:
871:Polypharmacology
796:
795:
769:
768:
759:Pharmacogenomics
754:Pharmacogenetics
733:
732:
696:
695:
657:
656:
584:
583:
554:Rate of infusion
529:
528:
524:Pharmacokinetics
459:
458:
404:
403:
353:
352:
315:
314:
310:Pharmacodynamics
290:Neurotransmitter
272:Enzyme inhibitor
237:
236:
192:
191:
172:
165:
158:
149:
148:
142:
141:
105:
1081:
1080:
1076:
1075:
1074:
1072:
1071:
1070:
1036:
1035:
1034:
1033:
976:
974:
965:
925:
911:Drug resistance
889:
845:
817:
790:
786:Neurotoxicology
763:
727:
690:
652:
646:
628:
578:
574:Bioavailability
559:Onset of action
514:
453:
398:
347:
304:
276:
267:Inverse agonist
231:
217:Partial agonist
181:
176:
146:
145:
106:
102:
97:
67:
46:
41:
12:
11:
5:
1079:
1069:
1068:
1063:
1058:
1053:
1048:
1032:
1031:
1024:
1017:
1009:
1006:
1005:
988:
971:
970:
967:
966:
964:
963:
958:
953:
951:Bacteriostatic
948:
943:
937:
935:
927:
926:
924:
923:
918:
913:
908:
903:
901:Drug tolerance
897:
895:
888:
883:
881:Lists of drugs
878:
873:
868:
863:
858:
853:
851:
847:
846:
844:
843:
838:
833:
828:
822:
819:
818:
816:
815:
810:
804:
802:
800:Drug discovery
792:
791:
789:
788:
783:
777:
775:
765:
764:
762:
761:
756:
751:
745:
743:
729:
728:
726:
725:
720:
715:
710:
704:
702:
692:
691:
689:
684:
679:
674:
669:
667:
654:
648:
647:
645:
644:
642:Bioequivalence
639:
633:
630:
629:
627:
626:
616:
611:
606:
601:
590:
588:
580:
579:
577:
576:
571:
566:
561:
556:
551:
541:
535:
533:
526:
520:
519:
516:
515:
513:
512:
507:
502:
476:
471:
465:
463:
455:
454:
452:
451:
436:
431:
426:
421:
416:
410:
408:
400:
399:
397:
396:
386:
384:Adverse effect
381:
376:
371:
359:
357:
349:
348:
346:
341:
336:
331:
329:Mode of action
326:
321:
319:
312:
306:
305:
303:
302:
297:
292:
287:
281:
278:
277:
275:
274:
269:
264:
259:
254:
249:
243:
241:
233:
232:
230:
229:
224:
219:
214:
209:
204:
198:
196:
189:
183:
182:
175:
174:
167:
160:
152:
144:
143:
116:(20): 4550–4.
99:
98:
96:
93:
92:
91:
66:
63:
62:
61:
56:, and so does
45:
42:
40:
37:
9:
6:
4:
3:
2:
1078:
1067:
1064:
1062:
1059:
1057:
1054:
1052:
1049:
1047:
1044:
1043:
1041:
1030:
1025:
1023:
1018:
1016:
1011:
1010:
1004:
1002:
998:
995:article is a
994:
989:
986:
982:
981:
977:
962:
959:
957:
954:
952:
949:
947:
944:
942:
939:
938:
936:
932:
922:
919:
917:
914:
912:
909:
907:
906:Tachyphylaxis
904:
902:
899:
898:
896:
892:
887:
884:
882:
879:
877:
874:
872:
869:
867:
864:
862:
859:
857:
854:
852:
848:
842:
839:
837:
834:
832:
829:
827:
824:
823:
814:
811:
809:
806:
805:
803:
801:
797:
787:
784:
782:
779:
778:
776:
774:
770:
760:
757:
755:
752:
750:
747:
746:
744:
742:
738:
734:
724:
721:
719:
716:
714:
711:
709:
706:
705:
703:
701:
697:
688:
685:
683:
680:
678:
675:
673:
670:
668:
666:
662:
658:
655:
649:
643:
640:
638:
635:
634:
624:
620:
617:
615:
612:
610:
607:
605:
602:
599:
595:
592:
591:
589:
585:
575:
572:
570:
567:
565:
562:
560:
557:
555:
552:
549:
545:
542:
540:
537:
536:
534:
530:
527:
525:
521:
511:
508:
506:
503:
500:
496:
492:
488:
484:
480:
477:
475:
472:
470:
467:
466:
464:
460:
449:
445:
441:
437:
435:
432:
430:
427:
425:
422:
420:
417:
415:
412:
411:
409:
405:
394:
393:Neurotoxicity
390:
387:
385:
382:
380:
377:
375:
372:
369:
365:
362:Selectivity (
361:
360:
358:
354:
345:
342:
340:
337:
335:
332:
330:
327:
325:
322:
320:
316:
313:
311:
307:
301:
300:Pharmacophore
298:
296:
293:
291:
288:
286:
283:
282:
273:
270:
268:
265:
263:
260:
258:
255:
253:
250:
248:
245:
244:
242:
238:
228:
225:
223:
220:
218:
215:
213:
210:
208:
205:
203:
200:
199:
197:
193:
190:
188:
184:
180:
173:
168:
166:
161:
159:
154:
153:
150:
139:
135:
131:
127:
123:
119:
115:
111:
104:
100:
89:
85:
81:
77:
73:
69:
68:
59:
55:
51:
48:
47:
36:
34:
30:
26:
22:
18:
1001:expanding it
993:biochemistry
990:
975:
876:Chemotherapy
836:Cell biology
737:Biochemistry
661:Neuroscience
609:Distribution
539:Loading dose
261:
226:
222:Superagonist
179:Pharmacology
113:
110:FEBS Letters
109:
103:
28:
23:at the same
16:
15:
961:Bactericide
637:Compartment
448:Patch clamp
424:Schild plot
50:Epinephrine
1056:Physiology
1040:Categories
841:Physiology
773:Toxicology
665:psychology
614:Metabolism
604:Absorption
598:Liberation
440:Organ bath
368:Functional
247:Antagonist
240:Inhibitory
195:Excitatory
95:References
33:antagonist
623:Clearance
619:Excretion
438:Methods (
88:histamine
741:genetics
713:Pharmacy
700:Medicine
510:Affinity
469:Efficacy
407:Analysis
389:Toxicity
138:39722975
130:16083876
78:for the
52:induces
39:Examples
25:receptor
21:agonists
651:Related
594:(L)ADME
548:Initial
532:Metrics
479:Potency
462:Metrics
364:Binding
334:Binding
202:Agonist
76:ligands
653:fields
136:
128:
991:This
850:Other
587:LADME
134:S2CID
997:stub
739:and
663:and
499:TD50
495:LD50
491:ED50
487:IC50
483:EC50
285:Drug
126:PMID
596:: (
118:doi
114:579
1042::
497:,
493:,
489:,
485:,
446:,
442:,
366:,
132:.
124:.
112:.
1028:e
1021:t
1014:v
1003:.
625:)
621:(
600:)
550:)
546:(
501:)
481:(
450:)
395:)
391:(
370:)
171:e
164:t
157:v
140:.
120::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.