392:. The role of PI3K has been investigated by several laboratories. Accumulating data suggests that, while this molecule is, in general, part of growth signaling complex, it plays a more profound role in controlling cell migration. The different ligand isoforms have variable affinities for the receptor isoforms, and the receptor isoforms may variably form hetero- or homo- dimers. This leads to specificity of downstream signaling. It has been shown that the
456:
stimulated by epidermal growth factor (EGF) versus PDGF. However, comparing the signaling pathways between them reveals that the PI3K pathway is exclusively activated by PDGF, with EGF having no effect. Chemically inhibiting the PI3K pathway in PDGF-stimulated cells negates the differential effect between the two growth factors, and actually gives PDGF an edge in osteogenic differentiation.
421:
differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C) which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis.
36:
461:
cells into an osteogenic lineage in the presence of PDGF, and thus might reduce the need for higher concentrations of PDGF or other growth factors, making PDGF a more viable growth factor for osteogenic differentiation than other, more expensive growth factors currently used in the field such as BMP2.
534:
A non-viral PDGF "bio patch" can regenerate missing or damaged bone by delivering DNA in a nano-sized particle directly into cells via genes. Repairing bone fractures, fixing craniofacial defects and improving dental implants are among potential uses. The patch employs a collagen platform seeded with
359:
receptor. Two types of PDGFRs have been identified: alpha-type and beta-type PDGFRs. The alpha type binds to PDGF-AA, PDGF-BB and PDGF-AB, whereas the beta type PDGFR binds with high affinity to PDGF-BB and PDGF-AB. PDGF binds to the PDGFR ligand binding pocket located within the second and third
451:
in order to divide. It has been shown that in monocytes-macrophages and fibroblasts, exogenously administered PDGF stimulates chemotaxis, proliferation, and gene expression and significantly augmented the influx of inflammatory cells and fibroblasts, accelerating extracellular matrix and collagen
460:
is a PI3K-specific inhibitor, and treatment of cells with
Wortmannin in combination with PDGF resulted in enhanced osteoblast differentiation compared to just PDGF alone, as well as compared to EGF. These results indicate that the addition of Wortmannin can significantly increase the response of
420:
populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration,
455:
In terms of osteogenic differentiation of mesenchymal stem cells, comparing PDGF to epidermal growth factor (EGF), which is also implicated in stimulating cell growth, proliferation, and differentiation, MSCs were shown to have stronger osteogenic differentiation into bone-forming cells when
236:. In both mouse and human, the PDGF signalling network consists of five ligands, PDGF-AA through -DD (including -AB), and two receptors, PDGFRalpha and PDGFRbeta. All PDGFs function as secreted, disulphide-linked homodimers, but only PDGFA and B can form functional heterodimers.
831:
Tischer, Edmund; Gospodarowicz, Denis; Mitchell, Richard; Silva, Maria; Schilling, James; Lau, Kenneth; Crisp, Tracey; Fiddes, John C.; Abraham, Judith A. (December 1989). "Vascular endothelial growth factor: A new member of the platelet-derived growth factor gene family".
530:
Age related downregulation of the PDGF receptor on islet beta cells has been demonstrated to prevent islet beta cell proliferation in both animal and human cells and its re-expression triggered beta cell proliferation and corrected glucose regulation via insulin secretion.
1333:
Maglione D, Guerriero V, Viglietto G, Ferraro MG, Aprelikova O, Alitalo K, Del
Vecchio S, Lei KJ, Chou JY, Persico MG (1993). "Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14".
499:
and in orthopedic surgery and periodontics to stimulate bone regeneration and repair. PDGF may be beneficial when used by itself or especially in combination with other growth factors to stimulate soft and hard tissue healing (Lynch et al. 1987, 1989, 1991, 1995).
1815:
Demonstration of the safety and efficacy of rhPDGF-BB in the healing of chronic foot ulcers in diabetic patients and regeneration of alveolar (jaw) bone lost due to chronic infection from periodontal disease has resulted in two FDA-approved products based on this
202:, the growth of blood vessels from already-existing blood vessel tissue, mitogenesis, i.e. proliferation, of mesenchymal cells such as fibroblasts, osteoblasts, tenocytes, vascular smooth muscle cells and mesenchymal stem cells as well as
1869:
McClintock JT, Chan IJ, Thaker SR, Katial A, Taub FE, Aotaki-Keen AE, Hjelmeland LM (1992). "Detection of c-sis proto-oncogene transcripts by direct enzyme-labeled cDNA probes and in situ hybridization".
1049:"Differential requirement of a motif within the carboxyl-terminal domain of alpha-platelet-derived growth factor (alpha PDGF) receptor for PDGF focus forming activity chemotaxis, or growth"
1789:
Friedlaender GE, Lin S, Solchaga LA, Snel LB, Lynch SE (2013). "The role of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in orthopaedic bone repair and regeneration".
957:"Chimeric alpha- and beta-platelet-derived growth factor (PDGF) receptors define three immunoglobulin-like domains of the alpha-PDGF receptor that determine PDGF-AA binding specificity"
5690:
377:
2636:
5710:
1830:"An antibody reactive with domain 4 of the platelet-derived growth factor beta receptor allows BB binding while inhibiting proliferation by impairing receptor dimerization"
5700:
3479:
535:
particles containing the genes needed for producing bone. In experiments, new bone fully covered skull wounds in test animals and stimulated growth in human bone marrow
3855:
147:
1521:
Kratchmarova I, Blagoev B, Haack-Sorensen M, Kassem M, Mann M (June 2005). "Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation".
1959:
Elangovan, S.; d'Mello, S. R.; Hong, L.; Ross, R. D.; Allamargot, C.; Dawson, D. V.; Stanford, C. M.; Johnson, G. K.; Sumner, D. R.; Salem, A. K. (2013-11-12).
5685:
440:, fibrotic disorders and malignancies. Synthesis occurs due to external stimuli such as thrombin, low oxygen tension, or other cytokines and growth factors.
243:), and released by platelets upon activation, it is also produced by other cells including smooth muscle cells, activated macrophages, and endothelial cells
4220:
2629:
468:(OPCs). It has also been shown that fibroblast growth factor (FGF) activates a signaling pathway that positively regulates the PDGF receptors in OPCs.
1584:, Hart IK, Coles HS, Burne JF, Voyvodic JT, Richardson WD, Raff MC (1992). "Cell Death and Control of Cell Survival in the Oligodendrocyte Lineage".
5455:
3530:
5394:
4571:
3763:
3472:
6354:
4496:
393:
400:. PDGF-BB is the highest-affinity ligand for the PDGFR-beta; PDGFR-beta is a key marker of hepatic stellate cell activation in the process of
6078:
5991:
5936:
5890:
5835:
5570:
5510:
4511:
4441:
4000:
3598:
3540:
2893:
2622:
1646:
McKinnon RD, Matsui T, Dubois-Dalcq M, Aaronson SA (November 1990). "FGF modulates the PDGF-driven pathway of oligodendrocyte development".
6073:
5951:
5850:
5636:
5525:
5325:
5285:
5033:
4952:
4814:
4755:
4717:
4662:
4657:
4647:
4521:
4516:
4486:
4461:
4456:
4446:
4332:
4251:
4190:
4118:
4097:
4082:
4035:
3688:
998:"12/15-Lipoxygenase Contributes to Platelet-derived Growth Factor-induced Activation of Signal Transducer and Activator of Transcription 3"
725:
996:
Blazevic T, Schwaiberger AV, Schreiner CE, Schachner D, Schaible AM, Grojer CS, Atanasov AG, Werz O, Dirsch VM, Heiss EH (December 2013).
6173:
6031:
6010:
5966:
5946:
5865:
5845:
5560:
5540:
5520:
5163:
5158:
4491:
4215:
3748:
3545:
1088:
Ataliotis, P; Symes, K; Chou, MM; Ho, L; Mercola, M (September 1995). "PDGF signalling is required for gastrulation of
Xenopus laevis".
5996:
5986:
5941:
5895:
5885:
5840:
5664:
5631:
5611:
5575:
5565:
5515:
5475:
4947:
4927:
4894:
4775:
4677:
4526:
3465:
3123:
5956:
5855:
5750:
5654:
5606:
5599:
5585:
5530:
5500:
4980:
4970:
4922:
4904:
4833:
4667:
4506:
4451:
2967:
2962:
1361:
1286:"A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases"
5695:
5385:
2146:
1960:
1389:
Alvarez RH, Kantarjian HM, Cortes JE (September 2006). "Biology of platelet-derived growth factor and its involvement in disease".
4990:
4707:
609:
447:, a type of connective tissue cell that is especially prevalent in wound healing. In essence, the PDGFs allow a cell to skip the
1473:
Pierce GF, Mustoe TA, Altrock BW, Deuel TF, Thomason A (April 1991). "Role of platelet-derived growth factor in wound healing".
916:"Role of alpha beta receptor heterodimer formation in beta platelet-derived growth factor (PDGF) receptor activation by PDGF-AB"
5795:
3975:
3658:
3314:
2500:
2495:
2371:
1934:
750:
1225:
Olofsson B, Pajusola K, Kaipainen A, von Euler G, Joukov V, Saksela O, Orpana A, Pettersson RF, Alitalo K, Eriksson U (1996).
1125:"Embryonic mesoderm cells spread in response to platelet-derived growth factor and signaling by phosphatidylinositol 3-kinase"
6373:
6323:
6294:
6241:
4728:
4595:
796:
Fredriksson, Linda; Li, Hong; Eriksson, Ulf (August 2004). "The PDGF family: four gene products form five dimeric isoforms".
780:
95:
167:
6052:
6048:
6044:
6040:
3593:
3577:
2572:
2567:
2562:
592:
588:
584:
253:
and in orthopedic surgery and periodontics as an alternative to bone autograft to stimulate bone regeneration and repair.
4321:
4240:
4107:
4024:
2063:
Amaral, Ronaldo Jose Farias Correa; Cavanagh, Brenton; O'Brien, Fergal Joseph; Kearney, Cathal John (16 December 2018).
2014:
Elangovan S, D'Mello SR, Hong L, Ross RD, Allamargot C, Dawson DV, Stanford CM, Johnson GK, Sumner DR, Salem AK (2014).
6036:
2554:
640:
Hannink M, Donoghue DJ (1989). "Structure and function of platelet-derived growth factor (PDGF) and related proteins".
580:
5725:
4844:
4404:
4015:
2174:
3673:
3617:
3608:
2819:
508:
Like many other growth factors that have been linked to disease, PDGF and its receptors have provided a market for
6247:
2460:
2389:
465:
6334:
6310:
5450:
4869:
2189:
155:
6300:
914:
Heidaran MA, Pierce JH, Yu JC, Lombardi D, Artrip JE, Fleming TP, Thomason A, Aaronson SA (25 October 1991).
6344:
4740:
4622:
4612:
2448:
2443:
2139:
2016:"The enhancement of bone regeneration by gene activated matrix encoding for platelet derived growth factor"
1284:
Joukov V, Pajusola K, Kaipainen A, Chilov D, Lahtinen I, Kukk E, Saksela O, Kalkkinen N, Alitalo K (1996).
2114:
5715:
2933:
2577:
2339:
1629:
360:
immunoglobulin domains. Upon activation by PDGF, these receptors dimerise, and are "switched on" by auto-
6329:
4155:
2947:
2855:
2771:
2742:
2433:
2416:
2381:
2218:
604:
151:
20:
213:
that can be composed of two A subunits (PDGF-AA), two B subunits (PDGF-BB), or one of each (PDGF-AB).
6237:
3343:
3181:
2981:
412:
PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated
373:
108:
1913:
6416:
4421:
4337:
4256:
4123:
4040:
2800:
2686:
2603:
2163:
2118:
2065:"Platelet-derived growth factor stabilises vascularisation in collagen-glycosaminoglycan scaffolds"
1633:
352:
316:
6411:
6021:
3768:
3643:
3026:
2704:
2582:
2366:
2132:
575:
542:
The addition of PDGF at specific time‐points has been shown to stabilise vasculature in collagen‐
344:
266:
729:
554:
Human genes encoding proteins that belong to the platelet-derived growth factor family include:
6305:
5921:
5825:
5445:
4864:
3850:
3488:
3403:
3212:
2064:
1748:
Mercola, M; Deininger, P L; Shamah, S M; Porter, J; Wang, C Y; Stiles, C D (1 December 1990).
867:
Matsui T, Heidaran M, Miki T, Popescu N, La
Rochelle W, Kraus M, Pierce J, Aaronson S (1989).
6379:
4576:
3860:
3499:
2902:
2713:
2657:
2645:
481:
6319:
5705:
4637:
4586:
3328:
1702:
1691:"Serum factor requirements of normal and simian virus 40-transformed 3T3 mouse fibroplasts"
1530:
1238:
1136:
880:
134:
8:
5460:
4874:
2786:
2598:
1365:
869:"Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes"
509:
496:
369:
250:
229:
1706:
1534:
1242:
1140:
884:
5138:
3491:
2841:
2614:
2094:
2040:
2031:
2015:
1985:
1976:
1937:. Med.stanford.edu – Stanford University School of Medicine. 2011-10-12. Archived from
1895:
1671:
1609:
1554:
1498:
1450:
1441:
1425:
1301:
1207:
1024:
997:
692:
1725:
1690:
1310:
1285:
973:
956:
932:
915:
701:
676:
480:
characterized, and has led to an understanding of the mechanism of many growth factor
5765:
2086:
2045:
1990:
1887:
1851:
1806:
1771:
1730:
1663:
1659:
1601:
1597:
1546:
1490:
1455:
1406:
1343:
1315:
1266:
1261:
1226:
1199:
1164:
1159:
1124:
1105:
1070:
1029:
978:
937:
896:
849:
845:
813:
776:
706:
657:
653:
543:
142:
100:
3457:
2098:
1938:
1675:
1613:
1558:
1211:
206:, the directed migration, of mesenchymal cells. Platelet-derived growth factor is a
64:
6183:
5315:
3278:
3055:
3041:
2076:
2035:
2027:
1980:
1972:
1899:
1879:
1841:
1798:
1761:
1720:
1710:
1655:
1593:
1538:
1502:
1482:
1445:
1437:
1398:
1305:
1297:
1256:
1246:
1227:"Vascular endothelial growth factor B, a novel growth factor for endothelial cells"
1191:
1154:
1144:
1097:
1060:
1019:
1009:
968:
927:
888:
841:
805:
696:
688:
649:
130:
809:
331:). The PDGF family also includes a few other members of the family, including the
3441:
2353:
492:
437:
385:
361:
356:
332:
246:
76:
1802:
6369:
6290:
6232:
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4884:
4879:
3525:
3515:
3510:
3244:
1129:
Proceedings of the
National Academy of Sciences of the United States of America
368:
domains, which serve to mediate binding of cofactors and subsequently activate
191:
484:.The first engineered dominant negative protein was designed to inhibit PDGF
6405:
6063:
5976:
5905:
5875:
5810:
5720:
5674:
5550:
5480:
5425:
5414:
4899:
4607:
4290:
4195:
4087:
3394:
3096:
3070:
2666:
2155:
1846:
1829:
512:
to treat disease. Such antagonists include (but are not limited to) specific
477:
309:
207:
195:
187:
1542:
1149:
1065:
1048:
1014:
955:
Heidaran MA, Pierce JH, Jensen RA, Matsui T, Aaronson SA (5 November 1990).
892:
6389:
6359:
6098:
6088:
5981:
5880:
5735:
5555:
5490:
5405:
4909:
4712:
4551:
4546:
4466:
4416:
4230:
3984:
3965:
3944:
3915:
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3633:
3157:
2917:
2090:
2049:
1994:
1810:
1766:
1749:
1550:
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1410:
1251:
1203:
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1033:
817:
620:
536:
429:
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210:
199:
1891:
1855:
1775:
1734:
1715:
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1605:
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1319:
1270:
1168:
1109:
1074:
982:
941:
900:
853:
710:
661:
104:
6349:
6315:
6213:
6203:
6198:
6188:
6138:
5961:
5860:
5621:
5535:
5465:
5360:
5123:
5088:
5038:
5001:
4937:
4819:
4750:
4702:
4692:
4687:
4682:
4566:
4561:
4556:
3934:
3845:
3835:
3803:
3798:
3793:
3788:
3778:
3738:
3703:
3012:
2728:
444:
233:
225:
221:
1961:"Bio patch can regrow bone for dental implants and craniofacial defects"
6168:
6133:
6128:
6118:
6108:
6026:
5815:
5790:
5780:
5626:
5580:
5440:
5266:
5235:
5204:
5173:
5118:
5093:
5073:
5058:
5048:
4942:
4859:
4652:
4632:
4531:
4476:
4471:
4295:
4200:
4185:
3980:
3939:
3911:
3880:
3840:
3743:
3698:
3693:
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3293:
3240:
3222:
3166:
2404:
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1883:
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1520:
457:
452:
formation and thus reducing the time for the healing process to occur.
448:
417:
413:
389:
203:
88:
2081:
1402:
1195:
995:
6193:
6163:
6158:
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6148:
6143:
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6113:
6103:
6093:
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5641:
5616:
5375:
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5365:
5355:
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5256:
5194:
5128:
5108:
5103:
5098:
5083:
5078:
5068:
5063:
4957:
4932:
4697:
4617:
4536:
4481:
4371:
4310:
4300:
4205:
4092:
3890:
3885:
3875:
3783:
3773:
3758:
3733:
3728:
3718:
3713:
3708:
2505:
2361:
1571:
Hayashi, A. The New
Standard of Care for Nonunions?. AAOS Now. 2009.
677:"Structural and functional studies on platelet-derived growth factor"
240:
1828:
Shulman T, Sauer FG, Jackman RM, Chang CN, Landolfi NF (July 1997).
1750:"Dominant-negative mutants of a platelet-derived growth factor gene"
868:
6364:
6083:
5740:
5340:
5330:
5310:
5053:
5043:
4390:
3870:
3813:
3723:
3683:
3446:
3191:
3186:
2824:
2649:
2315:
614:
524:
517:
513:
71:
5245:
5214:
5183:
5147:
1645:
1224:
1182:
Hoch RV, Soriano P (2003). "Roles of PDGF in animal development".
6339:
5760:
5225:
4627:
3588:
2490:
2429:
2124:
1935:"New Stanford molecular target for diabetes treatment discovered"
1332:
830:
433:
365:
262:
217:
83:
2062:
6252:
5916:
5805:
5730:
5435:
5430:
4854:
4849:
4803:
4799:
4795:
4791:
4787:
4783:
4779:
4431:
3970:
3648:
3226:
3139:
1426:"The activation of Akt/PKB signaling pathway and cell survival"
425:
327:
321:
270:
162:
265:
of PDGF that activate cellular response through two different
6284:
6280:
6276:
6272:
6268:
6264:
6260:
6256:
5971:
5870:
5545:
5485:
5299:
5022:
5018:
5014:
5010:
4501:
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3259:
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2529:
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2334:
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2300:
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2258:
2249:
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2236:
2232:
1283:
1047:
Yu JC, Li W, Wang LM, Uren A, Pierce JH, Heidaran MA (1995).
570:
566:
562:
558:
381:
305:
299:
293:
287:
281:
275:
239:
Though PDGF is synthesized, stored (in the alpha granules of
2013:
1958:
1747:
5755:
4361:
4357:
4353:
4349:
4345:
4341:
4276:
4272:
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4147:
4143:
4139:
4135:
4131:
4127:
4068:
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3988:
3954:
3919:
3900:
3416:
3411:
3376:
3298:
3075:
2815:
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2228:
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2202:
2198:
2193:
2185:
1788:
397:
124:
59:
1868:
954:
384:
pathway. Downstream effects of this include regulation of
3360:
3217:
3207:
2996:
866:
2644:
1827:
1472:
913:
2069:
Journal of Tissue
Engineering and Regenerative Medicine
1516:
1514:
1512:
1388:
35:
6355:
Pituitary adenylate cyclase-activating peptide (PACAP)
520:
of interest, which act only in a neutralizing manner.
3487:
795:
432:. Over-expression of PDGF has been linked to several
428:
development, cell proliferation, cell migration, and
1580:
1509:
1087:
443:
PDGF is a required element in cellular division for
16:
Signaling glycoprotein regulating cell proliferation
1914:"Researchers make older beta cells act young again"
834:
617:
platelet involvement in smooth muscle proliferation
19:"PDGF" redirects here. For the space hardware, see
6301:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
5159:Glial cell line-derived neurotrophic factor (GDNF)
4812:Cleavage products/derivatives with unknown target:
3402:
198:. In particular, PDGF plays a significant role in
1688:
6403:
6335:Macrophage-stimulating protein (MSP; HLP, HGFLP)
464:PDGF is also known to maintain proliferation of
40:Platelet-derived growth factor BB monomer, Human
3976:Heparin-binding EGF-like growth factor (HB-EGF)
3659:Heparin-binding EGF-like growth factor (HB-EGF)
1384:
1382:
773:Robbins and Coltran Pathologic Basis of Disease
639:
751:"The Basic Biology of Platelet Growth Factors"
6387:Additional growth factor receptor modulators:
3473:
2665:
2630:
2140:
1625:
1623:
1423:
4741:Insulin-like growth factor-2 (somatomedin A)
4623:Insulin-like growth factor-2 (somatomedin A)
4613:Insulin-like growth factor-1 (somatomedin C)
1782:
1417:
1379:
1122:
1046:
989:
1821:
1639:
1466:
1326:
1277:
1218:
1181:
1175:
256:
3480:
3466:
2637:
2623:
2147:
2133:
1620:
668:
633:
2117:at the U.S. National Library of Medicine
2080:
2039:
1984:
1845:
1765:
1724:
1714:
1632:at the U.S. National Library of Medicine
1449:
1309:
1260:
1250:
1158:
1148:
1123:Symes, K; Mercola, M (3 September 1996).
1064:
1023:
1013:
972:
931:
700:
674:
6345:Migration-stimulating factor (MSF; PRG4)
3674:Transforming growth factor alpha (TGFα)
610:Platelet-derived growth factor receptor
6404:
6248:Connective tissue growth factor (CTGF)
249:PDGF is used in medicine to help heal
6311:Hepatoma-derived growth factor (HDGF)
3461:
2618:
2128:
770:
1689:Paul D, Lipton A, Klinger I (1971).
798:Cytokine & Growth Factor Reviews
723:
315:. The ligands interact with the two
2863:
2808:
2674:
775:. China: Elsevier. pp. 88–89.
13:
3252:
3034:
2955:
2779:
2750:
2721:
2154:
2032:10.1016/j.biomaterials.2013.10.021
1977:10.1016/j.biomaterials.2013.10.021
1442:10.1111/j.1582-4934.2005.tb00337.x
1302:10.1002/j.1460-2075.1996.tb00359.x
693:10.1002/j.1460-2075.1992.tb05523.x
14:
6428:
2108:
549:
396:is derived from the PDGF B-chain
6330:Leukemia inhibitory factor (LIF)
1424:Song G, Ouyang G, Bao S (2005).
623:potent inhibitor of angiogenesis
466:oligodendrocyte progenitor cells
34:
5498:Negative allosteric modulators:
2461:Relaxin family peptide hormones
2056:
2007:
1952:
1927:
1906:
1862:
1741:
1682:
1574:
1565:
1354:
1116:
1081:
1040:
948:
5816:Gossypetin (3,5,7,8,3',4'-HHF)
5007:Platelet-derived growth factor
2115:platelet-derived+growth+factor
907:
860:
824:
789:
764:
743:
717:
180:Platelet-derived growth factor
29:Platelet-derived growth factor
1:
6022:Placental growth factor (PGF)
1791:Current Pharmaceutical Design
1630:Proto-Oncogene+Proteins+c-sis
974:10.1016/S0021-9258(17)30572-0
933:10.1016/S0021-9258(18)54914-0
810:10.1016/j.cytogfr.2004.03.007
627:
378:reactive oxygen species (ROS)
338:
119:Available protein structures:
6306:Glia maturation factor (GMF)
4815:Glypromate (GPE, (1-3)IGF-1)
2894:Intracellular signaling P+Ps
1916:. Eurekalert.org. 2011-10-12
1660:10.1016/0896-6273(90)90215-2
1598:10.1016/0092-8674(92)90531-G
1231:Proc. Natl. Acad. Sci. U.S.A
846:10.1016/0006-291X(89)92729-0
654:10.1016/0304-419x(89)90031-0
380:-mediated activation of the
7:
1803:10.2174/1381612811319190005
726:"Global Path Course: Video"
598:
503:
487:
407:
372:, for example, through the
10:
6433:
6238:Colony-stimulating factors
6230:Additional growth factors:
2948:TGF beta signaling pathway
2856:JAK-STAT signaling pathway
2772:TGF beta signaling pathway
2743:Hedgehog signaling pathway
2434:Insulin-like growth factor
1971:(2). KurzweilAI: 737–747.
605:Platelet-activating factor
495:PDGF is used to help heal
476:PDGF was one of the first
471:
364:of several sites on their
21:Power Data Grapple Fixture
18:
6222:
6009:
5904:
5673:
5586:SNA-120 (pegylated K252a)
5413:
5404:
5384:
5298:
5275:
5244:
5213:
5182:
5146:
5137:
4989:
4832:
4765:
4758:(against IGF-1 and IGF-2)
4727:
4720:(against IGF-1 and IGF-2)
4594:
4585:
4403:
4380:
4320:
4239:
4106:
4023:
4014:
3953:
3899:
3812:
3616:
3607:
3576:
3498:
3429:
3393:
3369:
3336:
3327:
3307:
3286:
3277:
3239:
3200:
3174:
3165:
3156:
3132:
3116:
3109:
3089:
3063:
3054:
3025:
3005:
2989:
2982:Akt/PKB signaling pathway
2980:
2946:
2926:
2910:
2901:
2892:
2854:
2799:
2770:
2741:
2712:
2703:
2656:
2591:
2553:
2520:
2457:
2426:
2415:
2380:
2352:
2310:
2271:
2215:
2171:
2162:
261:There are five different
161:
141:
123:
118:
114:
94:
82:
70:
58:
50:
45:
33:
28:
4422:Hepatocyte growth factor
3981:Neuregulins (heregulins)
3912:Neuregulins (heregulins)
3856:Trastuzumab duocarmazine
3569:(against angiopoietin 2)
3563:(against angiopoietin 3)
2801:Receptor tyrosine kinase
2119:Medical Subject Headings
1847:10.1074/jbc.272.28.17400
1695:Proc Natl Acad Sci U S A
1634:Medical Subject Headings
353:receptor tyrosine kinase
317:tyrosine kinase receptor
257:Types and classification
186:) is one among numerous
3769:Depatuxizumab mafodotin
3027:Hippo signaling pathway
2274:FGF homologous factors:
1754:Genes & Development
1543:10.1126/science.1107627
1150:10.1073/pnas.93.18.9641
1066:10.1074/jbc.270.13.7033
1015:10.1074/jbc.M113.489013
893:10.1126/science.2536956
6392:(neurotrophin mixture)
6380:Wnt signaling proteins
6061:Allosteric modulators:
5781:Norwogonin (5,7,8-THF)
4001:5 (tomoregulin, TMEFF)
3851:Trastuzumab deruxtecan
3489:Growth factor receptor
3042:Neurofibromin 2/Merlin
2646:Tumor suppressor genes
1872:In Vitro Cell Dev Biol
1767:10.1101/gad.4.12b.2333
1252:10.1073/pnas.93.6.2576
1102:10.1242/dev.121.9.3099
642:Biochim. Biophys. Acta
527:is derived from PDGF.
200:blood vessel formation
6320:T-cell growth factors
4577:Telisotuzumab vedotin
3861:Trastuzumab emtansine
2903:Wnt signaling pathway
2714:Wnt signaling pathway
1716:10.1073/pnas.68.3.645
1487:10.1002/jcb.240450403
771:Kumar, Vinay (2010).
424:PDGF plays a role in
4905:EVT-901 (SAR-127963)
4638:Mecasermin rinfabate
3329:Transcription factor
2555:Vascular endothelial
510:receptor antagonists
3404:Apoptosis inhibitor
2787:TGF beta receptor 2
1840:(28): 17400–17404.
1707:1971PNAS...68..645P
1535:2005Sci...308.1472K
1529:(5727): 1472–1477.
1243:1996PNAS...93.2576O
1141:1996PNAS...93.9641S
1008:(49): 35592–35603.
967:(31): 18741–18744.
885:1989Sci...243..800M
376:pathway or through
370:signal transduction
351:is classified as a
230:smooth muscle cells
6071:Kinase inhibitors:
5934:Kinase inhibitors:
5833:Kinase inhibitors:
5508:Kinase inhibitors:
5323:Kinase inhibitors:
5283:Kinase inhibitors:
5264:Kinase inhibitors:
5233:Kinase inhibitors:
5202:Kinase inhibitors:
5171:Kinase inhibitors:
5031:Kinase inhibitors:
4645:Kinase inhibitors:
4439:Kinase inhibitors:
4228:Kinase inhibitors:
4221:Aprutumab ixadotin
3868:Kinase inhibitors:
3681:Kinase inhibitors:
3538:Kinase inhibitors:
1884:10.1007/BF02631013
1760:(12b): 2333–2341.
675:Heldin CH (1992).
482:signaling pathways
319:monomers, PDGFRα (
273:include: PDGF-AA (
224:origin, including
6399:
6398:
6005:
6004:
5766:N-Acetylserotonin
5665:ReN-1820 (TrkAd5)
5294:
5293:
4828:
4827:
4773:Binding proteins:
4432:Dihexa (PNB-0408)
4399:
4398:
4010:
4009:
3924:6 (neuroglycan C)
3644:EGF (urogastrone)
3622:
3455:
3454:
3425:
3424:
3389:
3388:
3385:
3384:
3323:
3322:
3273:
3272:
3235:
3234:
3152:
3151:
3148:
3147:
3105:
3104:
3050:
3049:
3021:
3020:
2976:
2975:
2942:
2941:
2888:
2887:
2884:
2883:
2850:
2849:
2795:
2794:
2766:
2765:
2737:
2736:
2699:
2698:
2695:
2694:
2612:
2611:
2516:
2515:
2348:
2347:
2082:10.1002/term.2789
1797:(19): 3384–3390.
1430:J. Cell. Mol. Med
1403:10.4065/81.9.1241
1196:10.1242/dev.00721
1190:(20): 4769–4784.
1059:(13): 7033–7036.
879:(4892): 800–804.
782:978-1-4160-3121-5
687:(12): 4251–4259.
544:glycosaminoglycan
355:(RTK), a type of
216:PDGF is a potent
177:
176:
173:
172:
168:structure summary
6424:
6211:Decoy receptors:
6184:Alacizumab pegol
5662:Decoy receptors:
5411:
5410:
5316:Stem cell factor
5257:Persephin (PSPN)
5195:Neurturin (NRTN)
5144:
5143:
4981:LEVI-04 (p75-Fc)
4978:Decoy receptors:
4592:
4591:
4021:
4020:
3620:
3614:
3613:
3482:
3475:
3468:
3459:
3458:
3400:
3399:
3334:
3333:
3284:
3283:
3279:Ubiquitin ligase
3250:
3249:
3172:
3171:
3163:
3162:
3114:
3113:
3061:
3060:
3056:MAPK/ERK pathway
3032:
3031:
2987:
2986:
2953:
2952:
2908:
2907:
2899:
2898:
2861:
2860:
2806:
2805:
2777:
2776:
2748:
2747:
2719:
2718:
2710:
2709:
2672:
2671:
2663:
2662:
2639:
2632:
2625:
2616:
2615:
2522:Platelet-derived
2464:
2437:
2424:
2423:
2318:
2276:
2222:
2179:
2169:
2168:
2149:
2142:
2135:
2126:
2125:
2103:
2102:
2084:
2060:
2054:
2053:
2043:
2011:
2005:
2004:
2002:
2001:
1988:
1956:
1950:
1949:
1947:
1946:
1931:
1925:
1924:
1922:
1921:
1910:
1904:
1903:
1866:
1860:
1859:
1849:
1825:
1819:
1818:
1786:
1780:
1779:
1769:
1745:
1739:
1738:
1728:
1718:
1686:
1680:
1679:
1643:
1637:
1627:
1618:
1617:
1578:
1572:
1569:
1563:
1562:
1518:
1507:
1506:
1475:J. Cell. Biochem
1470:
1464:
1463:
1453:
1421:
1415:
1414:
1397:(9): 1241–1257.
1386:
1377:
1376:
1374:
1373:
1364:. Archived from
1358:
1352:
1351:
1330:
1324:
1323:
1313:
1281:
1275:
1274:
1264:
1254:
1237:(6): 2567–2581.
1222:
1216:
1215:
1179:
1173:
1172:
1162:
1152:
1120:
1114:
1113:
1096:(9): 3099–3110.
1085:
1079:
1078:
1068:
1044:
1038:
1037:
1027:
1017:
993:
987:
986:
976:
952:
946:
945:
935:
911:
905:
904:
864:
858:
857:
840:(3): 1198–1206.
828:
822:
821:
793:
787:
786:
768:
762:
761:
759:
758:
753:. September 2004
747:
741:
740:
738:
737:
728:. Archived from
724:Minarcik, John.
721:
715:
714:
704:
672:
666:
665:
637:
516:that target the
116:
115:
38:
26:
25:
6432:
6431:
6427:
6426:
6425:
6423:
6422:
6421:
6417:Protein domains
6402:
6401:
6400:
6395:
6340:Midkine (NEGF2)
6218:
6001:
5900:
5669:
5607:ABT-110 (PG110)
5400:
5380:
5290:
5271:
5240:
5209:
5178:
5133:
4985:
4923:ABT-110 (PG110)
4824:
4761:
4723:
4581:
4395:
4376:
4316:
4313:(against FGF23)
4235:
4102:
4006:
3949:
3895:
3808:
3619:
3603:
3572:
3494:
3486:
3456:
3451:
3430:Other/ungrouped
3421:
3381:
3365:
3319:
3303:
3269:
3231:
3196:
3144:
3128:
3101:
3097:Neurofibromin 1
3085:
3046:
3017:
3001:
2972:
2938:
2922:
2880:
2846:
2791:
2762:
2733:
2691:
2652:
2643:
2613:
2608:
2587:
2549:
2512:
2458:
2453:
2427:
2418:
2411:
2376:
2354:EGF-like domain
2344:
2311:
2306:
2272:
2267:
2216:
2211:
2172:
2158:
2153:
2111:
2106:
2061:
2057:
2012:
2008:
1999:
1997:
1957:
1953:
1944:
1942:
1933:
1932:
1928:
1919:
1917:
1912:
1911:
1907:
1867:
1863:
1826:
1822:
1787:
1783:
1746:
1742:
1687:
1683:
1644:
1640:
1628:
1621:
1579:
1575:
1570:
1566:
1519:
1510:
1471:
1467:
1422:
1418:
1391:Mayo Clin. Proc
1387:
1380:
1371:
1369:
1362:"PDGF Pathways"
1360:
1359:
1355:
1331:
1327:
1282:
1278:
1223:
1219:
1180:
1176:
1121:
1117:
1086:
1082:
1045:
1041:
994:
990:
953:
949:
926:(30): 20232–7.
912:
908:
865:
861:
829:
825:
794:
790:
783:
769:
765:
756:
754:
749:
748:
744:
735:
733:
722:
718:
673:
669:
638:
634:
630:
601:
552:
506:
490:
474:
438:atherosclerosis
410:
386:gene expression
362:phosphorylation
341:
333:VEGF sub-family
259:
41:
24:
17:
12:
11:
5:
6430:
6420:
6419:
6414:
6412:Growth factors
6397:
6396:
6394:
6393:
6383:
6382:
6377:
6370:Thrombopoietin
6367:
6362:
6357:
6352:
6347:
6342:
6337:
6332:
6327:
6313:
6308:
6303:
6298:
6291:Erythropoietin
6288:
6250:
6245:
6235:
6233:Adrenomedullin
6226:
6224:
6220:
6219:
6217:
6216:
6207:
6206:
6201:
6196:
6191:
6186:
6177:
6176:
6171:
6166:
6161:
6156:
6151:
6146:
6141:
6136:
6131:
6126:
6121:
6116:
6111:
6106:
6101:
6096:
6091:
6086:
6081:
6076:
6067:
6066:
6057:
6056:
6034:
6029:
6024:
6015:
6013:
6007:
6006:
6003:
6002:
6000:
5999:
5994:
5989:
5984:
5979:
5974:
5969:
5964:
5959:
5954:
5949:
5944:
5939:
5930:
5929:
5924:
5919:
5910:
5908:
5902:
5901:
5899:
5898:
5893:
5888:
5883:
5878:
5873:
5868:
5863:
5858:
5853:
5848:
5843:
5838:
5829:
5828:
5819:
5818:
5813:
5808:
5799:
5798:
5793:
5788:
5783:
5778:
5773:
5768:
5763:
5758:
5753:
5748:
5743:
5738:
5733:
5728:
5723:
5718:
5713:
5708:
5703:
5698:
5696:4'-DMA-7,8-DHF
5693:
5688:
5679:
5677:
5671:
5670:
5668:
5667:
5658:
5657:
5645:
5644:
5639:
5634:
5629:
5624:
5619:
5614:
5609:
5590:
5589:
5583:
5578:
5573:
5568:
5563:
5558:
5553:
5548:
5543:
5538:
5533:
5528:
5523:
5518:
5513:
5504:
5503:
5494:
5493:
5488:
5483:
5478:
5469:
5468:
5463:
5458:
5456:Gambogic amide
5453:
5448:
5443:
5438:
5433:
5428:
5419:
5417:
5408:
5402:
5401:
5399:
5398:
5390:
5388:
5382:
5381:
5379:
5378:
5373:
5368:
5363:
5358:
5353:
5348:
5343:
5338:
5333:
5328:
5319:
5318:
5313:
5304:
5302:
5296:
5295:
5292:
5291:
5289:
5288:
5279:
5277:
5273:
5272:
5270:
5269:
5260:
5259:
5250:
5248:
5242:
5241:
5239:
5238:
5229:
5228:
5226:Artemin (ARTN)
5219:
5217:
5211:
5210:
5208:
5207:
5198:
5197:
5188:
5186:
5180:
5179:
5177:
5176:
5167:
5166:
5161:
5152:
5150:
5141:
5135:
5134:
5132:
5131:
5126:
5121:
5112:
5111:
5106:
5101:
5096:
5091:
5086:
5081:
5076:
5071:
5066:
5061:
5056:
5051:
5046:
5041:
5036:
5027:
5026:
5004:
4995:
4993:
4987:
4986:
4984:
4983:
4974:
4973:
4961:
4960:
4955:
4950:
4945:
4940:
4935:
4930:
4925:
4913:
4912:
4907:
4902:
4897:
4888:
4887:
4882:
4877:
4872:
4867:
4862:
4857:
4852:
4847:
4838:
4836:
4830:
4829:
4826:
4825:
4823:
4822:
4817:
4808:
4807:
4769:
4767:
4763:
4762:
4760:
4759:
4753:
4744:
4743:
4733:
4731:
4725:
4724:
4722:
4721:
4715:
4710:
4705:
4700:
4695:
4690:
4685:
4680:
4671:
4670:
4665:
4660:
4655:
4650:
4641:
4640:
4635:
4630:
4625:
4620:
4615:
4610:
4600:
4598:
4589:
4583:
4582:
4580:
4579:
4574:
4569:
4564:
4559:
4554:
4549:
4540:
4539:
4534:
4529:
4524:
4519:
4514:
4509:
4504:
4499:
4494:
4489:
4484:
4479:
4474:
4469:
4464:
4459:
4454:
4449:
4444:
4435:
4434:
4425:
4424:
4419:
4409:
4407:
4401:
4400:
4397:
4396:
4394:
4393:
4384:
4382:
4378:
4377:
4375:
4374:
4369:
4335:
4326:
4324:
4318:
4317:
4315:
4314:
4304:
4303:
4298:
4293:
4288:
4254:
4245:
4243:
4237:
4236:
4234:
4233:
4224:
4223:
4218:
4209:
4208:
4203:
4198:
4193:
4188:
4183:
4121:
4112:
4110:
4104:
4103:
4101:
4100:
4095:
4090:
4085:
4080:
4038:
4029:
4027:
4018:
4012:
4011:
4008:
4007:
4005:
4004:
3978:
3973:
3968:
3959:
3957:
3951:
3950:
3948:
3947:
3942:
3937:
3928:
3927:
3905:
3903:
3897:
3896:
3894:
3893:
3888:
3883:
3878:
3873:
3864:
3863:
3858:
3853:
3848:
3843:
3838:
3829:
3828:
3818:
3816:
3810:
3809:
3807:
3806:
3801:
3796:
3791:
3786:
3781:
3776:
3771:
3766:
3761:
3752:
3751:
3746:
3741:
3736:
3731:
3726:
3721:
3716:
3711:
3706:
3701:
3696:
3691:
3686:
3677:
3676:
3671:
3666:
3661:
3656:
3651:
3646:
3641:
3636:
3626:
3624:
3611:
3605:
3604:
3602:
3601:
3596:
3591:
3582:
3580:
3574:
3573:
3571:
3570:
3564:
3554:
3553:
3548:
3543:
3534:
3533:
3531:Angiopoietin 3
3528:
3526:Angiopoietin 2
3519:
3518:
3516:Angiopoietin 4
3513:
3511:Angiopoietin 1
3504:
3502:
3496:
3495:
3485:
3484:
3477:
3470:
3462:
3453:
3452:
3450:
3449:
3444:
3439:
3433:
3431:
3427:
3426:
3423:
3422:
3420:
3419:
3414:
3408:
3406:
3397:
3391:
3390:
3387:
3386:
3383:
3382:
3380:
3379:
3373:
3371:
3367:
3366:
3364:
3363:
3358:
3357:
3356:
3351:
3340:
3338:
3331:
3325:
3324:
3321:
3320:
3318:
3317:
3311:
3309:
3305:
3304:
3302:
3301:
3296:
3290:
3288:
3281:
3275:
3274:
3271:
3270:
3268:
3267:
3262:
3256:
3254:
3247:
3237:
3236:
3233:
3232:
3230:
3229:
3220:
3215:
3210:
3204:
3202:
3198:
3197:
3195:
3194:
3189:
3184:
3178:
3176:
3169:
3160:
3154:
3153:
3150:
3149:
3146:
3145:
3143:
3142:
3136:
3134:
3130:
3129:
3127:
3126:
3120:
3118:
3111:
3107:
3106:
3103:
3102:
3100:
3099:
3093:
3091:
3087:
3086:
3084:
3083:
3078:
3073:
3067:
3065:
3058:
3052:
3051:
3048:
3047:
3045:
3044:
3038:
3036:
3029:
3023:
3022:
3019:
3018:
3016:
3015:
3009:
3007:
3003:
3002:
3000:
2999:
2993:
2991:
2984:
2978:
2977:
2974:
2973:
2971:
2970:
2965:
2959:
2957:
2950:
2944:
2943:
2940:
2939:
2937:
2936:
2930:
2928:
2924:
2923:
2921:
2920:
2914:
2912:
2905:
2896:
2890:
2889:
2886:
2885:
2882:
2881:
2879:
2878:
2873:
2867:
2865:
2858:
2852:
2851:
2848:
2847:
2845:
2844:
2839:
2834:
2833:
2832:
2827:
2812:
2810:
2803:
2797:
2796:
2793:
2792:
2790:
2789:
2783:
2781:
2774:
2768:
2767:
2764:
2763:
2761:
2760:
2754:
2752:
2745:
2739:
2738:
2735:
2734:
2732:
2731:
2725:
2723:
2716:
2707:
2701:
2700:
2697:
2696:
2693:
2692:
2690:
2689:
2684:
2678:
2676:
2669:
2667:Growth factors
2660:
2654:
2653:
2642:
2641:
2634:
2627:
2619:
2610:
2609:
2607:
2606:
2601:
2595:
2593:
2589:
2588:
2586:
2585:
2580:
2575:
2570:
2565:
2559:
2557:
2551:
2550:
2548:
2547:
2542:
2537:
2532:
2526:
2524:
2518:
2517:
2514:
2513:
2511:
2510:
2509:
2508:
2503:
2498:
2488:
2483:
2478:
2473:
2467:
2465:
2455:
2454:
2452:
2451:
2446:
2440:
2438:
2421:
2419:Relaxin family
2413:
2412:
2410:
2409:
2408:
2407:
2402:
2397:
2386:
2384:
2378:
2377:
2375:
2374:
2369:
2364:
2358:
2356:
2350:
2349:
2346:
2345:
2343:
2342:
2337:
2332:
2327:
2321:
2319:
2308:
2307:
2305:
2304:
2298:
2292:
2286:
2279:
2277:
2269:
2268:
2266:
2265:
2252:
2239:
2225:
2223:
2213:
2212:
2210:
2209:
2196:
2182:
2180:
2166:
2160:
2159:
2156:Growth factors
2152:
2151:
2144:
2137:
2129:
2123:
2122:
2110:
2109:External links
2107:
2105:
2104:
2075:(2): 261–273.
2055:
2026:(2): 737–747.
2006:
1951:
1926:
1905:
1878:(2): 102–108.
1861:
1820:
1781:
1740:
1701:(3): 645–652.
1681:
1654:(5): 603–614.
1638:
1619:
1573:
1564:
1508:
1481:(4): 319–326.
1465:
1416:
1378:
1353:
1342:(4): 925–931.
1325:
1296:(2): 290–298.
1276:
1217:
1174:
1135:(18): 9641–4.
1115:
1080:
1039:
988:
947:
906:
859:
823:
804:(4): 197–204.
788:
781:
763:
742:
716:
667:
631:
629:
626:
625:
624:
618:
612:
607:
600:
597:
596:
595:
578:
573:
551:
550:Family members
548:
505:
502:
497:chronic ulcers
489:
486:
478:growth factors
473:
470:
449:G1 checkpoints
409:
406:
340:
337:
297:), and -AB (a
258:
255:
251:chronic ulcers
190:that regulate
188:growth factors
175:
174:
171:
170:
165:
159:
158:
145:
139:
138:
128:
121:
120:
112:
111:
98:
92:
91:
86:
80:
79:
74:
68:
67:
62:
56:
55:
52:
48:
47:
43:
42:
39:
31:
30:
15:
9:
6:
4:
3:
2:
6429:
6418:
6415:
6413:
6410:
6409:
6407:
6391:
6388:
6385:
6384:
6381:
6378:
6375:
6371:
6368:
6366:
6363:
6361:
6358:
6356:
6353:
6351:
6348:
6346:
6343:
6341:
6338:
6336:
6333:
6331:
6328:
6325:
6321:
6317:
6314:
6312:
6309:
6307:
6304:
6302:
6299:
6296:
6292:
6289:
6286:
6282:
6278:
6274:
6270:
6266:
6262:
6258:
6254:
6251:
6249:
6246:
6243:
6239:
6236:
6234:
6231:
6228:
6227:
6225:
6221:
6215:
6212:
6209:
6208:
6205:
6202:
6200:
6197:
6195:
6192:
6190:
6187:
6185:
6182:
6179:
6178:
6175:
6172:
6170:
6167:
6165:
6162:
6160:
6157:
6155:
6152:
6150:
6147:
6145:
6142:
6140:
6137:
6135:
6132:
6130:
6127:
6125:
6122:
6120:
6117:
6115:
6112:
6110:
6107:
6105:
6102:
6100:
6097:
6095:
6092:
6090:
6087:
6085:
6082:
6080:
6077:
6075:
6072:
6069:
6068:
6065:
6064:Cyclotraxin B
6062:
6059:
6058:
6054:
6050:
6046:
6042:
6038:
6035:
6033:
6030:
6028:
6025:
6023:
6020:
6017:
6016:
6014:
6012:
6008:
5998:
5995:
5993:
5990:
5988:
5985:
5983:
5980:
5978:
5977:Larotrectinib
5975:
5973:
5970:
5968:
5965:
5963:
5960:
5958:
5955:
5953:
5950:
5948:
5945:
5943:
5940:
5938:
5935:
5932:
5931:
5928:
5925:
5923:
5920:
5918:
5915:
5912:
5911:
5909:
5907:
5903:
5897:
5894:
5892:
5889:
5887:
5884:
5882:
5879:
5877:
5876:Larotrectinib
5874:
5872:
5869:
5867:
5864:
5862:
5859:
5857:
5854:
5852:
5849:
5847:
5844:
5842:
5839:
5837:
5834:
5831:
5830:
5827:
5824:
5821:
5820:
5817:
5814:
5812:
5811:Cyclotraxin B
5809:
5807:
5804:
5801:
5800:
5797:
5794:
5792:
5789:
5787:
5784:
5782:
5779:
5777:
5774:
5772:
5769:
5767:
5764:
5762:
5759:
5757:
5754:
5752:
5749:
5747:
5744:
5742:
5739:
5737:
5734:
5732:
5729:
5727:
5724:
5722:
5721:Amitriptyline
5719:
5717:
5714:
5712:
5709:
5707:
5704:
5702:
5699:
5697:
5694:
5692:
5689:
5687:
5684:
5681:
5680:
5678:
5676:
5672:
5666:
5663:
5660:
5659:
5656:
5653:
5650:
5647:
5646:
5643:
5640:
5638:
5635:
5633:
5630:
5628:
5625:
5623:
5620:
5618:
5615:
5613:
5610:
5608:
5605:
5601:
5598:
5597:Against TrkA:
5595:
5592:
5591:
5587:
5584:
5582:
5579:
5577:
5574:
5572:
5569:
5567:
5564:
5562:
5559:
5557:
5554:
5552:
5551:Larotrectinib
5549:
5547:
5544:
5542:
5539:
5537:
5534:
5532:
5529:
5527:
5524:
5522:
5519:
5517:
5514:
5512:
5509:
5506:
5505:
5502:
5499:
5496:
5495:
5492:
5489:
5487:
5484:
5482:
5481:Dexamethasone
5479:
5477:
5474:
5471:
5470:
5467:
5464:
5462:
5459:
5457:
5454:
5452:
5449:
5447:
5444:
5442:
5439:
5437:
5434:
5432:
5429:
5427:
5426:Amitriptyline
5424:
5421:
5420:
5418:
5416:
5412:
5409:
5407:
5403:
5396:
5392:
5391:
5389:
5387:
5383:
5377:
5374:
5372:
5369:
5367:
5364:
5362:
5359:
5357:
5354:
5352:
5349:
5347:
5344:
5342:
5339:
5337:
5334:
5332:
5329:
5327:
5324:
5321:
5320:
5317:
5314:
5312:
5309:
5306:
5305:
5303:
5301:
5297:
5287:
5284:
5281:
5280:
5278:
5274:
5268:
5265:
5262:
5261:
5258:
5255:
5252:
5251:
5249:
5247:
5243:
5237:
5234:
5231:
5230:
5227:
5224:
5221:
5220:
5218:
5216:
5212:
5206:
5203:
5200:
5199:
5196:
5193:
5190:
5189:
5187:
5185:
5181:
5175:
5172:
5169:
5168:
5165:
5162:
5160:
5157:
5154:
5153:
5151:
5149:
5145:
5142:
5140:
5136:
5130:
5127:
5125:
5122:
5120:
5117:
5114:
5113:
5110:
5107:
5105:
5102:
5100:
5097:
5095:
5092:
5090:
5087:
5085:
5082:
5080:
5077:
5075:
5072:
5070:
5067:
5065:
5062:
5060:
5057:
5055:
5052:
5050:
5047:
5045:
5042:
5040:
5037:
5035:
5032:
5029:
5028:
5024:
5020:
5016:
5012:
5008:
5005:
5003:
5000:
4997:
4996:
4994:
4992:
4988:
4982:
4979:
4976:
4975:
4972:
4969:
4966:
4963:
4962:
4959:
4956:
4954:
4951:
4949:
4946:
4944:
4941:
4939:
4936:
4934:
4931:
4929:
4926:
4924:
4921:
4918:
4915:
4914:
4911:
4908:
4906:
4903:
4901:
4900:Dexamethasone
4898:
4896:
4893:
4890:
4889:
4886:
4883:
4881:
4878:
4876:
4873:
4871:
4868:
4866:
4863:
4861:
4858:
4856:
4853:
4851:
4848:
4846:
4843:
4840:
4839:
4837:
4835:
4831:
4821:
4818:
4816:
4813:
4810:
4809:
4805:
4801:
4797:
4793:
4789:
4785:
4781:
4777:
4774:
4771:
4770:
4768:
4764:
4757:
4754:
4752:
4749:
4746:
4745:
4742:
4738:
4735:
4734:
4732:
4730:
4726:
4719:
4716:
4714:
4711:
4709:
4706:
4704:
4701:
4699:
4696:
4694:
4691:
4689:
4686:
4684:
4681:
4679:
4676:
4673:
4672:
4669:
4666:
4664:
4661:
4659:
4656:
4654:
4651:
4649:
4646:
4643:
4642:
4639:
4636:
4634:
4631:
4629:
4626:
4624:
4621:
4619:
4616:
4614:
4611:
4609:
4608:des(1-3)IGF-1
4605:
4602:
4601:
4599:
4597:
4593:
4590:
4588:
4584:
4578:
4575:
4573:
4572:Telisotuzumab
4570:
4568:
4565:
4563:
4560:
4558:
4555:
4553:
4550:
4548:
4545:
4542:
4541:
4538:
4535:
4533:
4530:
4528:
4525:
4523:
4520:
4518:
4515:
4513:
4510:
4508:
4505:
4503:
4500:
4498:
4495:
4493:
4490:
4488:
4485:
4483:
4480:
4478:
4475:
4473:
4470:
4468:
4465:
4463:
4460:
4458:
4455:
4453:
4450:
4448:
4445:
4443:
4440:
4437:
4436:
4433:
4430:
4429:Potentiators:
4427:
4426:
4423:
4420:
4418:
4414:
4411:
4410:
4408:
4406:
4402:
4392:
4389:
4386:
4385:
4383:
4379:
4373:
4370:
4367:
4363:
4359:
4355:
4351:
4347:
4343:
4339:
4336:
4334:
4331:
4328:
4327:
4325:
4323:
4319:
4312:
4309:
4306:
4305:
4302:
4299:
4297:
4294:
4292:
4291:Selpercatinib
4289:
4286:
4282:
4278:
4274:
4270:
4266:
4262:
4258:
4255:
4253:
4250:
4247:
4246:
4244:
4242:
4238:
4232:
4229:
4226:
4225:
4222:
4219:
4217:
4214:
4211:
4210:
4207:
4204:
4202:
4199:
4197:
4196:Selpercatinib
4194:
4192:
4189:
4187:
4184:
4181:
4177:
4173:
4169:
4165:
4161:
4157:
4153:
4149:
4145:
4141:
4137:
4133:
4129:
4125:
4122:
4120:
4117:
4114:
4113:
4111:
4109:
4105:
4099:
4096:
4094:
4091:
4089:
4088:Selpercatinib
4086:
4084:
4081:
4078:
4074:
4070:
4066:
4062:
4058:
4054:
4050:
4046:
4042:
4039:
4037:
4034:
4031:
4030:
4028:
4026:
4022:
4019:
4017:
4013:
4002:
3998:
3994:
3990:
3986:
3982:
3979:
3977:
3974:
3972:
3969:
3967:
3964:
3961:
3960:
3958:
3956:
3952:
3946:
3943:
3941:
3938:
3936:
3933:
3930:
3929:
3925:
3921:
3917:
3913:
3910:
3907:
3906:
3904:
3902:
3898:
3892:
3889:
3887:
3884:
3882:
3879:
3877:
3874:
3872:
3869:
3866:
3865:
3862:
3859:
3857:
3854:
3852:
3849:
3847:
3844:
3842:
3839:
3837:
3834:
3831:
3830:
3827:
3823:
3820:
3819:
3817:
3815:
3811:
3805:
3802:
3800:
3797:
3795:
3792:
3790:
3787:
3785:
3782:
3780:
3777:
3775:
3772:
3770:
3767:
3765:
3764:Depatuxizumab
3762:
3760:
3757:
3754:
3753:
3750:
3747:
3745:
3742:
3740:
3737:
3735:
3732:
3730:
3727:
3725:
3722:
3720:
3717:
3715:
3712:
3710:
3707:
3705:
3702:
3700:
3697:
3695:
3692:
3690:
3687:
3685:
3682:
3679:
3678:
3675:
3672:
3670:
3667:
3665:
3662:
3660:
3657:
3655:
3652:
3650:
3647:
3645:
3642:
3640:
3637:
3635:
3631:
3628:
3627:
3625:
3623:
3615:
3612:
3610:
3606:
3600:
3597:
3595:
3592:
3590:
3587:
3584:
3583:
3581:
3579:
3575:
3568:
3565:
3562:
3559:
3556:
3555:
3552:
3549:
3547:
3544:
3542:
3539:
3536:
3535:
3532:
3529:
3527:
3524:
3521:
3520:
3517:
3514:
3512:
3509:
3506:
3505:
3503:
3501:
3497:
3493:
3490:
3483:
3478:
3476:
3471:
3469:
3464:
3463:
3460:
3448:
3445:
3443:
3440:
3438:
3435:
3434:
3432:
3428:
3418:
3415:
3413:
3410:
3409:
3407:
3405:
3401:
3398:
3396:
3395:Mitochondrion
3392:
3378:
3375:
3374:
3372:
3368:
3362:
3359:
3355:
3352:
3350:
3347:
3346:
3345:
3342:
3341:
3339:
3335:
3332:
3330:
3326:
3316:
3313:
3312:
3310:
3306:
3300:
3297:
3295:
3292:
3291:
3289:
3285:
3282:
3280:
3276:
3266:
3263:
3261:
3258:
3257:
3255:
3251:
3248:
3246:
3242:
3238:
3228:
3224:
3221:
3219:
3216:
3214:
3211:
3209:
3206:
3205:
3203:
3199:
3193:
3190:
3188:
3185:
3183:
3180:
3179:
3177:
3173:
3170:
3168:
3164:
3161:
3159:
3155:
3141:
3138:
3137:
3135:
3131:
3125:
3122:
3121:
3119:
3115:
3112:
3110:Other/unknown
3108:
3098:
3095:
3094:
3092:
3088:
3082:
3079:
3077:
3074:
3072:
3069:
3068:
3066:
3062:
3059:
3057:
3053:
3043:
3040:
3039:
3037:
3033:
3030:
3028:
3024:
3014:
3011:
3010:
3008:
3004:
2998:
2995:
2994:
2992:
2988:
2985:
2983:
2979:
2969:
2966:
2964:
2961:
2960:
2958:
2954:
2951:
2949:
2945:
2935:
2932:
2931:
2929:
2925:
2919:
2916:
2915:
2913:
2909:
2906:
2904:
2900:
2897:
2895:
2891:
2877:
2874:
2872:
2869:
2868:
2866:
2862:
2859:
2857:
2853:
2843:
2840:
2838:
2835:
2831:
2828:
2826:
2823:
2822:
2821:
2817:
2814:
2813:
2811:
2807:
2804:
2802:
2798:
2788:
2785:
2784:
2782:
2778:
2775:
2773:
2769:
2759:
2756:
2755:
2753:
2749:
2746:
2744:
2740:
2730:
2727:
2726:
2724:
2720:
2717:
2715:
2711:
2708:
2706:
2702:
2688:
2685:
2683:
2680:
2679:
2677:
2673:
2670:
2668:
2664:
2661:
2659:
2655:
2651:
2647:
2640:
2635:
2633:
2628:
2626:
2621:
2620:
2617:
2605:
2602:
2600:
2597:
2596:
2594:
2590:
2584:
2581:
2579:
2576:
2574:
2571:
2569:
2566:
2564:
2561:
2560:
2558:
2556:
2552:
2546:
2543:
2541:
2538:
2536:
2533:
2531:
2528:
2527:
2525:
2523:
2519:
2507:
2504:
2502:
2499:
2497:
2494:
2493:
2492:
2489:
2487:
2484:
2482:
2479:
2477:
2474:
2472:
2469:
2468:
2466:
2463:
2462:
2456:
2450:
2447:
2445:
2442:
2441:
2439:
2436:
2435:
2431:
2425:
2422:
2420:
2414:
2406:
2403:
2401:
2398:
2396:
2393:
2392:
2391:
2388:
2387:
2385:
2383:
2379:
2373:
2370:
2368:
2365:
2363:
2360:
2359:
2357:
2355:
2351:
2341:
2338:
2336:
2333:
2331:
2328:
2326:
2323:
2322:
2320:
2317:
2314:
2313:hormone-like:
2309:
2302:
2299:
2296:
2293:
2290:
2287:
2284:
2281:
2280:
2278:
2275:
2270:
2264:
2260:
2256:
2253:
2251:
2247:
2243:
2240:
2238:
2234:
2230:
2227:
2226:
2224:
2221:
2220:
2214:
2208:
2204:
2200:
2197:
2195:
2191:
2187:
2184:
2183:
2181:
2178:
2176:
2170:
2167:
2165:
2161:
2157:
2150:
2145:
2143:
2138:
2136:
2131:
2130:
2127:
2120:
2116:
2113:
2112:
2100:
2096:
2092:
2088:
2083:
2078:
2074:
2070:
2066:
2059:
2051:
2047:
2042:
2037:
2033:
2029:
2025:
2021:
2017:
2010:
1996:
1992:
1987:
1982:
1978:
1974:
1970:
1966:
1962:
1955:
1941:on 2013-10-21
1940:
1936:
1930:
1915:
1909:
1901:
1897:
1893:
1889:
1885:
1881:
1877:
1873:
1865:
1857:
1853:
1848:
1843:
1839:
1835:
1834:J. Biol. Chem
1831:
1824:
1817:
1812:
1808:
1804:
1800:
1796:
1792:
1785:
1777:
1773:
1768:
1763:
1759:
1755:
1751:
1744:
1736:
1732:
1727:
1722:
1717:
1712:
1708:
1704:
1700:
1696:
1692:
1685:
1677:
1673:
1669:
1665:
1661:
1657:
1653:
1649:
1642:
1635:
1631:
1626:
1624:
1615:
1611:
1607:
1603:
1599:
1595:
1591:
1587:
1583:
1577:
1568:
1560:
1556:
1552:
1548:
1544:
1540:
1536:
1532:
1528:
1524:
1517:
1515:
1513:
1504:
1500:
1496:
1492:
1488:
1484:
1480:
1476:
1469:
1461:
1457:
1452:
1447:
1443:
1439:
1435:
1431:
1427:
1420:
1412:
1408:
1404:
1400:
1396:
1392:
1385:
1383:
1368:on 2006-11-13
1367:
1363:
1357:
1349:
1345:
1341:
1337:
1329:
1321:
1317:
1312:
1307:
1303:
1299:
1295:
1291:
1287:
1280:
1272:
1268:
1263:
1258:
1253:
1248:
1244:
1240:
1236:
1232:
1228:
1221:
1213:
1209:
1205:
1201:
1197:
1193:
1189:
1185:
1178:
1170:
1166:
1161:
1156:
1151:
1146:
1142:
1138:
1134:
1130:
1126:
1119:
1111:
1107:
1103:
1099:
1095:
1091:
1084:
1076:
1072:
1067:
1062:
1058:
1054:
1053:J. Biol. Chem
1050:
1043:
1035:
1031:
1026:
1021:
1016:
1011:
1007:
1003:
1002:J. Biol. Chem
999:
992:
984:
980:
975:
970:
966:
962:
961:J. Biol. Chem
958:
951:
943:
939:
934:
929:
925:
921:
920:J. Biol. Chem
917:
910:
902:
898:
894:
890:
886:
882:
878:
874:
870:
863:
855:
851:
847:
843:
839:
835:
827:
819:
815:
811:
807:
803:
799:
792:
784:
778:
774:
767:
752:
746:
732:on 2018-09-29
731:
727:
720:
712:
708:
703:
698:
694:
690:
686:
682:
678:
671:
663:
659:
655:
651:
647:
643:
636:
632:
622:
619:
616:
613:
611:
608:
606:
603:
602:
594:
590:
586:
582:
579:
577:
574:
572:
568:
564:
560:
557:
556:
555:
547:
545:
540:
538:
537:stromal cells
532:
528:
526:
521:
519:
515:
511:
501:
498:
494:
485:
483:
479:
469:
467:
462:
459:
453:
450:
446:
441:
439:
435:
431:
427:
422:
419:
415:
405:
403:
399:
395:
391:
387:
383:
379:
375:
371:
367:
363:
358:
354:
350:
346:
336:
334:
330:
329:
324:
323:
318:
314:
311:
308:
307:
302:
301:
296:
295:
290:
289:
284:
283:
278:
277:
272:
268:
264:
254:
252:
248:
244:
242:
237:
235:
231:
227:
223:
220:for cells of
219:
214:
212:
209:
205:
201:
197:
193:
189:
185:
181:
169:
166:
164:
160:
157:
153:
149:
146:
144:
140:
136:
132:
129:
126:
122:
117:
113:
110:
106:
102:
99:
97:
93:
90:
87:
85:
81:
78:
75:
73:
69:
66:
63:
61:
57:
53:
49:
44:
37:
32:
27:
22:
6390:Cerebrolysin
6386:
6360:Pleiotrophin
6316:Interleukins
6229:
6210:
6180:
6099:Fruquintinib
6089:Cabozantinib
6070:
6060:
6018:
5982:Lestaurtinib
5933:
5913:
5881:Lestaurtinib
5832:
5822:
5803:Antagonists:
5802:
5736:Deoxygedunin
5691:3,7,8,2'-THF
5682:
5661:
5652:Against NGF:
5651:
5648:
5604:Against NGF:
5603:
5596:
5593:
5556:Lestaurtinib
5507:
5497:
5491:Testosterone
5473:Antagonists:
5472:
5422:
5322:
5307:
5282:
5263:
5253:
5232:
5222:
5201:
5191:
5170:
5155:
5115:
5030:
5006:
4998:
4977:
4968:Against NGF:
4967:
4964:
4920:Against NGF:
4919:
4916:
4910:Testosterone
4892:Antagonists:
4891:
4841:
4811:
4772:
4747:
4736:
4713:Teprotumumab
4674:
4644:
4603:
4552:Ficlatuzumab
4547:Emibetuzumab
4543:
4497:JNJ-38877605
4467:Cabozantinib
4438:
4428:
4417:Fosgonimeton
4412:
4387:
4329:
4307:
4248:
4231:Infigratinib
4227:
4212:
4115:
4032:
3966:Betacellulin
3962:
3945:Seribantumab
3931:
3908:
3867:
3832:
3826:Unknown/none
3825:
3821:
3755:
3680:
3639:Betacellulin
3634:Amphiregulin
3629:
3621:(ErbB1/HER1)
3585:
3557:
3537:
3523:Antagonists:
3522:
3507:
3500:Angiopoietin
2918:Beta-catenin
2681:
2521:
2459:
2428:
2417:Insulin/IGF/
2382:TGFβ pathway
2312:
2273:
2217:
2175:FGF receptor
2173:
2072:
2068:
2058:
2023:
2020:Biomaterials
2019:
2009:
1998:. Retrieved
1968:
1965:Biomaterials
1964:
1954:
1943:. Retrieved
1939:the original
1929:
1918:. Retrieved
1908:
1875:
1871:
1864:
1837:
1833:
1823:
1814:
1794:
1790:
1784:
1757:
1753:
1743:
1698:
1694:
1684:
1651:
1647:
1641:
1592:(1): 31–46.
1589:
1585:
1576:
1567:
1526:
1522:
1478:
1474:
1468:
1436:(1): 59–71.
1433:
1429:
1419:
1394:
1390:
1370:. Retrieved
1366:the original
1356:
1339:
1335:
1328:
1293:
1289:
1279:
1234:
1230:
1220:
1187:
1183:
1177:
1132:
1128:
1118:
1093:
1089:
1083:
1056:
1052:
1042:
1005:
1001:
991:
964:
960:
950:
923:
919:
909:
876:
872:
862:
837:
833:
826:
801:
797:
791:
772:
766:
755:. Retrieved
745:
734:. Retrieved
730:the original
719:
684:
680:
670:
645:
641:
635:
621:Withaferin A
553:
541:
533:
529:
523:The "c-Sis"
522:
507:
491:
475:
463:
454:
442:
430:angiogenesis
423:
411:
402:fibrogenesis
394:sis oncogene
357:cell surface
348:
342:
326:
320:
312:
304:
298:
292:
291:), and -DD (
286:
280:
274:
260:
245:
238:
215:
211:glycoprotein
183:
179:
178:
6350:Oncomodulin
6214:Aflibercept
6204:Ranibizumab
6199:Ramucirumab
6189:Bevacizumab
6181:Antibodies:
6139:Regorafenib
6079:Altiratinib
5992:ONO-5390556
5962:Entrectinib
5937:Altiratinib
5891:ONO-5390556
5861:Entrectinib
5836:Altiratinib
5622:Frunevetmab
5594:Antibodies:
5571:ONO-5390556
5536:Entrectinib
5511:Altiratinib
5466:Tavilermide
5361:Quizartinib
5300:SCF (c-Kit)
5124:Ramucirumab
5116:Antibodies:
5089:Quizartinib
5039:Avapritinib
5002:Becaplermin
4938:Frunevetmab
4917:Antibodies:
4820:Trofinetide
4751:Dusigitumab
4748:Antibodies:
4703:Robatumumab
4693:Figitumumab
4688:Dalotuzumab
4683:Cixutumumab
4675:Antibodies:
4567:Rilotumumab
4562:Onartuzumab
4557:Flanvotumab
4544:Antibodies:
4512:PF-04217903
4442:Altiratinib
4405:HGF (c-Met)
4308:Antibodies:
4213:Antibodies:
3935:Duligotumab
3932:Antibodies:
3846:Trastuzumab
3836:Ertumaxomab
3833:Antibodies:
3804:Zalutumumab
3799:Panitumumab
3794:Nimotuzumab
3789:Necitumumab
3779:Imgatuzumab
3756:Antibodies:
3739:Osimertinib
3704:Dacomitinib
3599:Dapiclermin
3558:Antibodies:
3541:Altiratinib
1184:Development
1090:Development
648:(1): 1–10.
546:scaffolds.
493:Recombinant
445:fibroblasts
325:) and -Rβ (
310:heterodimer
247:Recombinant
234:glial cells
226:fibroblasts
222:mesenchymal
194:growth and
46:Identifiers
6406:Categories
6169:Vandetanib
6134:Rebastinib
6129:Pegaptanib
6119:Nintedanib
6109:Lenvatinib
6074:Agerafenib
6027:Ripretinib
5952:CH-7057288
5851:CH-7057288
5716:7,8,3'-THF
5711:7,8,2'-THF
5637:Ranevetmab
5627:Fulranumab
5581:Rebastinib
5526:CH-7057288
5441:Cenegermin
5326:Agerafenib
5286:Agerafenib
5267:Vandetanib
5236:Vandetanib
5205:Vandetanib
5174:Vandetanib
5119:Olaratumab
5094:Ripretinib
5074:Nintedanib
5059:Lenvatinib
5049:Crenolanib
5034:Agerafenib
4953:Ranevetmab
4943:Fulranumab
4860:Cenegermin
4834:LNGF (p75)
4756:Xentuzumab
4718:Xentuzumab
4663:NVP-AEW541
4658:NVP-ADW742
4653:Linsitinib
4648:BMS-754807
4633:Mecasermin
4532:Tivantinib
4522:PHA-665752
4517:PF-2341066
4487:Golvatinib
4477:Crizotinib
4472:Capmatinib
4462:BMS-777607
4457:Amuvatinib
4333:Ersofermin
4296:Sprifermin
4252:Ersofermin
4201:Sprifermin
4191:Repifermin
4186:Palifermin
4119:Ersofermin
4098:Velafermin
4083:Repifermin
4036:Ersofermin
3955:ErbB4/HER4
3940:Patritumab
3901:ErbB3/HER3
3881:Mubritinib
3841:Pertuzumab
3814:ErbB2/HER2
3744:Vandetanib
3699:Canertinib
3694:Brigatinib
3689:Agerafenib
3669:Nepidermin
3664:Murodermin
3654:Epiregulin
3609:EGF (ErbB)
3567:Nesvacumab
3561:Evinacumab
3551:Rebastinib
3492:modulators
3241:DNA repair
3167:Cell cycle
2682:c-Sis/PDGF
2604:Hepatocyte
2164:Fibroblast
2000:2013-12-28
1945:2013-12-28
1920:2013-12-28
1372:2007-11-17
757:2014-05-08
736:2011-06-27
628:References
514:antibodies
458:Wortmannin
418:progenitor
414:mesenchyme
390:cell cycle
347:for PDGF,
339:Mechanisms
204:chemotaxis
131:structures
6194:Icrucumab
6174:WHI-P 154
6164:Tivozanib
6159:Toceranib
6154:Sunitinib
6149:Sorafenib
6144:Semaxanib
6124:Pazopanib
6114:Motesanib
6104:Lapatinib
6094:Cediranib
6032:Telbermin
6019:Agonists:
5967:GZ-389988
5947:CE-245677
5914:Agonists:
5866:GZ-389988
5846:CE-245677
5746:Diosmetin
5683:Agonists:
5649:Aptamers:
5642:Tanezumab
5617:Fasinumab
5561:Milciclib
5541:GZ-389988
5521:CE-245677
5423:Agonists:
5376:Toceranib
5371:Sunitinib
5366:Sorafenib
5356:Pazopanib
5351:Nilotinib
5346:Masitinib
5336:Dasatinib
5308:Agonists:
5254:Agonists:
5223:Agonists:
5192:Agonists:
5164:Liatermin
5156:Agonists:
5139:RET (GFL)
5129:Tovetumab
5109:Toceranib
5104:Sorafenib
5099:Sunitinib
5084:Radotinib
5079:Pazopanib
5069:Motesanib
5064:Masitinib
4999:Agonists:
4965:Aptamers:
4958:Tanezumab
4933:Fasinumab
4842:Agonists:
4698:Ganitumab
4618:IGF-1 LR3
4537:Volitinib
4492:INCB28060
4482:Foretinib
4388:Agonists:
4372:Trafermin
4330:Agonists:
4311:Burosumab
4301:Trafermin
4249:Agonists:
4216:Aprutumab
4206:Trafermin
4168:10 (KGF2)
4116:Agonists:
4093:Trafermin
4073:10 (KGF2)
4033:Agonists:
3963:Agonists:
3909:Agonists:
3891:Tucatinib
3886:Neratinib
3876:Lapatinib
3784:Matuzumab
3774:Futuximab
3759:Cetuximab
3749:WHI-P 154
3734:Neratinib
3729:Lapatinib
3719:Grandinin
3714:Gefitinib
3709:Erlotinib
3586:Agonists:
3546:CE-245677
3508:Agonists:
2650:Oncogenes
1582:Barres BA
426:embryonic
416:and some
366:cytosolic
267:receptors
241:platelets
89:PDOC00222
77:IPR000072
6376:instead)
6365:Renalase
6326:instead)
6297:instead)
6244:instead)
6084:Axitinib
6053:D (FIGF)
5997:PLX-7486
5987:ONO-4474
5942:AZD-6918
5896:PLX-7486
5886:ONO-4474
5841:AZD-6918
5823:Ligands:
5741:Deprenyl
5701:7,3'-DHF
5632:MEDI-578
5612:ASP-6294
5576:PLX-7486
5566:ONO-4474
5516:AZD-6918
5476:ALE-0540
5397:instead.
5341:Imatinib
5331:Axitinib
5311:Ancestim
5276:Unsorted
5054:Imatinib
5044:Axitinib
4948:MEDI-578
4928:ASP-6294
4895:ALE-0540
4737:Agonists
4678:AVE-1642
4604:Agonists
4527:SU-11274
4413:Agonists
4391:FGF15/19
4381:Unsorted
4346:2 (bFGF)
4265:2 (bFGF)
4132:2 (bFGF)
4049:2 (bFGF)
3871:Afatinib
3822:Agonists
3724:Icotinib
3684:Afatinib
3630:Agonists
3447:Stathmin
3192:Cyclin E
3187:Cyclin D
2825:HER2/neu
2705:Receptor
2316:FGF15/19
2177:ligands:
2099:58767660
2091:30554484
2050:24161167
1995:24161167
1816:molecule
1811:23432673
1676:23026544
1614:11529297
1559:10690497
1551:15933201
1460:15784165
1411:16970222
1336:Oncogene
1212:24124211
1204:12952899
1034:24165129
818:15207811
615:atheroma
599:See also
525:oncogene
518:molecule
504:Research
488:Medicine
436:such as
434:diseases
408:Function
388:and the
345:receptor
285:), -CC (
279:), -BB (
269:. Known
263:isoforms
196:division
148:RCSB PDB
72:InterPro
6253:Ephrins
5957:DS-6051
5856:DS-6051
5761:LM22A-4
5751:DMAQ-B1
5706:7,8-DHF
5686:3,7-DHF
5655:RBM-004
5600:GBR-900
5531:DS-6051
5501:VM-902A
4971:RBM-004
4668:OSl-906
4628:Insulin
4507:MK-2461
4452:AMG-458
3589:Axokine
3437:c-Bcl-2
3245:Fanconi
3158:Nucleus
2491:Relaxin
2430:Insulin
2041:3855224
1986:3855224
1900:9958016
1892:1537750
1856:9211881
1776:2279701
1735:5276775
1703:Bibcode
1668:2171589
1606:1623522
1531:Bibcode
1523:Science
1503:8539542
1495:2045423
1451:6741304
1348:7681160
1320:8617204
1271:8637916
1239:Bibcode
1169:8790383
1137:Bibcode
1110:7555734
1075:7706238
1025:3853304
983:2172231
942:1657917
901:2536956
881:Bibcode
873:Science
854:2610687
711:1425569
662:2546599
472:History
271:ligands
218:mitogen
208:dimeric
84:PROSITE
65:PF00341
6223:Others
5917:BNN-20
5806:ANA-12
5731:BNN-20
5451:DHEA-S
5436:BNN-27
5431:BNN-20
4870:DHEA-S
4855:BNN-27
4850:BNN-20
4766:Others
3971:Epigen
3649:Epigen
3227:p14arf
3140:Maspin
2820:c-ErbB
2658:Ligand
2578:VEGF-D
2573:VEGF-C
2568:VEGF-B
2563:VEGF-A
2372:HB-EGF
2303:(FHF4)
2297:(FHF2)
2291:(FHF1)
2285:(FHF3)
2121:(MeSH)
2097:
2089:
2048:
2038:
1993:
1983:
1898:
1890:
1854:
1809:
1774:
1733:
1726:389008
1723:
1674:
1666:
1648:Neuron
1636:(MeSH)
1612:
1604:
1557:
1549:
1501:
1493:
1458:
1448:
1409:
1346:
1318:
1311:449944
1308:
1290:EMBO J
1269:
1259:
1210:
1202:
1167:
1157:
1108:
1073:
1032:
1022:
981:
940:
899:
852:
816:
779:
709:
702:556997
699:
681:EMBO J
660:
328:PDGFRB
322:PDGFRA
163:PDBsum
137:
127:
109:SUPFAM
51:Symbol
6372:(see
6322:(see
6293:(see
6240:(see
5972:K252a
5871:K252a
5546:K252a
5486:FX007
5246:GFRα4
5215:GFRα3
5184:GFRα2
5148:GFRα1
4776:IGFBP
4729:IGF-2
4708:R1507
4596:IGF-1
4502:K252a
4322:FGFR4
4241:FGFR3
4108:FGFR2
4025:FGFR1
3442:Notch
3361:c-Myc
3354:c-Jun
3349:c-Fos
3265:BRCA2
3260:BRCA1
3124:c-Src
3081:c-Raf
3071:c-Ras
2997:c-Akt
2968:SMAD4
2963:SMAD2
2871:c-Kit
2842:c-Ret
2837:c-Met
2830:Her 3
2758:PTCH1
2599:Nerve
2592:Other
2545:PDGFD
2540:PDGFC
2535:PDGFB
2530:PDGFA
2486:INSL6
2481:INSL5
2476:INSL4
2471:INSL3
2405:TGFβ3
2400:TGFβ2
2395:TGFβ1
2340:FGF23
2335:FGF21
2330:FGF19
2325:FGF15
2301:FGF14
2295:FGF13
2289:FGF12
2283:FGF11
2263:FGF20
2259:FGF16
2250:FGF18
2246:FGF17
2237:FGF22
2233:FGF10
2095:S2CID
1896:S2CID
1672:S2CID
1610:S2CID
1555:S2CID
1499:S2CID
1262:39839
1208:S2CID
1160:38481
593:VEGFD
589:VEGFC
585:VEGFB
571:PDGFD
567:PDGFC
563:PDGFB
559:PDGFA
382:STAT3
349:PDGFR
306:PDGFB
300:PDGFA
294:PDGFD
288:PDGFC
282:PDGFB
276:PDGFA
105:SCOPe
96:SCOP2
6374:here
6324:here
6295:here
6242:here
6037:VEGF
6011:VEGF
5927:NT-3
5922:DHEA
5906:TrkC
5826:DHEA
5796:TDP6
5776:NT-4
5771:NT-3
5756:HIOC
5726:BDNF
5675:TrkB
5446:DHEA
5415:TrkA
5395:here
5393:See
5386:TGFβ
4991:PDGF
4885:NT-4
4880:NT-3
4865:DHEA
4845:BDNF
3594:CNTF
3578:CNTF
3417:SDHD
3412:SDHB
3377:KLF6
3344:AP-1
3337:ONCO
3299:MDM2
3287:ONCO
3182:CDK4
3175:ONCO
3117:ONCO
3076:HRAS
3064:ONCO
3013:PTEN
2990:ONCO
2911:ONCO
2876:Flt3
2864:ONCO
2816:ErbB
2809:ONCO
2729:CDH1
2675:ONCO
2648:and
2449:IGF2
2444:IGF1
2432:and
2390:TGFβ
2362:TGFα
2255:FGF9
2242:FGF8
2229:FGF7
2207:FGF6
2203:FGF4
2199:FGF3
2194:FGF5
2190:FGF2
2186:FGF1
2087:PMID
2046:PMID
1991:PMID
1888:PMID
1852:PMID
1807:PMID
1772:PMID
1731:PMID
1664:PMID
1602:PMID
1586:Cell
1547:PMID
1491:PMID
1456:PMID
1407:PMID
1344:PMID
1316:PMID
1267:PMID
1200:PMID
1165:PMID
1106:PMID
1071:PMID
1030:PMID
979:PMID
938:PMID
897:PMID
850:PMID
814:PMID
777:ISBN
707:PMID
658:PMID
581:VEGF
398:gene
374:PI3K
343:The
303:and
232:and
192:cell
184:PDGF
156:PDBj
152:PDBe
135:ECOD
125:Pfam
101:1pdg
60:Pfam
54:PDGF
5791:R13
5461:NGF
5406:Trk
4875:NGF
4587:IGF
4447:AM7
4338:FGF
4257:FGF
4158:),
4156:KGF
4124:FGF
4041:FGF
4016:FGF
3618:EGF
3370:TSP
3315:VHL
3308:TSP
3294:CBL
3253:TSP
3223:p16
3218:WT1
3213:pRb
3208:p53
3201:TSP
3133:TSP
3090:TSP
3035:TSP
3006:TSP
2956:TSP
2934:APC
2927:TSP
2780:TSP
2751:TSP
2722:TSP
2687:HGF
2583:PGF
2367:EGF
2219:KGF
2077:doi
2036:PMC
2028:doi
1981:PMC
1973:doi
1880:doi
1876:28A
1842:doi
1838:272
1799:doi
1762:doi
1721:PMC
1711:doi
1656:doi
1594:doi
1539:doi
1527:308
1483:doi
1446:PMC
1438:doi
1399:doi
1306:PMC
1298:doi
1257:PMC
1247:doi
1192:doi
1188:130
1155:PMC
1145:doi
1098:doi
1094:121
1061:doi
1057:270
1020:PMC
1010:doi
1006:288
969:doi
965:265
928:doi
924:266
889:doi
877:243
842:doi
838:165
806:doi
697:PMC
689:doi
650:doi
646:989
576:PGF
228:,
143:PDB
6408::
6285:B3
6283:,
6281:B2
6279:,
6277:B1
6275:,
6273:A5
6271:,
6269:A4
6267:,
6265:A3
6263:,
6261:A2
6259:,
6257:A1
6051:,
6047:,
6043:,
5786:R7
5602:;
5021:,
5017:,
5013:,
4802:,
4798:,
4794:,
4790:,
4786:,
4782:,
4739::
4606::
4415::
4366:19
4364:,
4360:,
4356:,
4352:,
4348:,
4344:,
4285:23
4283:,
4281:18
4279:,
4275:,
4271:,
4267:,
4263:,
4180:22
4178:,
4176:18
4174:,
4172:17
4170:,
4166:,
4162:,
4150:,
4146:,
4142:,
4138:,
4134:,
4130:,
4077:20
4075:,
4071:,
4067:,
4063:,
4059:,
4055:,
4051:,
4047:,
3999:,
3995:,
3991:,
3987:,
3922:,
3918:,
3824::
3632::
2093:.
2085:.
2073:13
2071:.
2067:.
2044:.
2034:.
2024:35
2022:.
2018:.
1989:.
1979:.
1969:35
1967:.
1963:.
1894:.
1886:.
1874:.
1850:.
1836:.
1832:.
1813:.
1805:.
1795:19
1793:.
1770:.
1756:.
1752:.
1729:.
1719:.
1709:.
1699:68
1697:.
1693:.
1670:.
1662:.
1650:.
1622:^
1608:.
1600:.
1590:70
1588:.
1553:.
1545:.
1537:.
1525:.
1511:^
1497:.
1489:.
1479:45
1477:.
1454:.
1444:.
1432:.
1428:.
1405:.
1395:81
1393:.
1381:^
1338:.
1314:.
1304:.
1294:15
1292:.
1288:.
1265:.
1255:.
1245:.
1235:93
1233:.
1229:.
1206:.
1198:.
1186:.
1163:.
1153:.
1143:.
1133:93
1131:.
1127:.
1104:.
1092:.
1069:.
1055:.
1051:.
1028:.
1018:.
1004:.
1000:.
977:.
963:.
959:.
936:.
922:.
918:.
895:.
887:.
875:.
871:.
848:.
836:.
812:.
802:15
800:.
705:.
695:.
685:11
683:.
679:.
656:.
644:.
591:;
587:;
583:;
569:;
565:;
561:;
539:.
404:.
335:.
154:;
150:;
133:/
107:/
103:/
6318:/
6287:)
6255:(
6055:)
6049:C
6045:B
6041:A
6039:(
5588:)
5025:)
5023:D
5019:C
5015:B
5011:A
5009:(
4806:)
4804:7
4800:6
4796:5
4792:4
4788:3
4784:2
4780:1
4778:(
4368:)
4362:9
4358:8
4354:6
4350:4
4342:1
4340:(
4287:)
4277:9
4273:8
4269:4
4261:1
4259:(
4182:)
4164:9
4160:8
4154:(
4152:7
4148:6
4144:5
4140:4
4136:3
4128:1
4126:(
4079:)
4069:8
4065:6
4061:5
4057:4
4053:3
4045:1
4043:(
4003:)
3997:4
3993:3
3989:2
3985:1
3983:(
3926:)
3920:2
3916:1
3914:(
3481:e
3474:t
3467:v
3243:/
3225:/
2818:/
2638:e
2631:t
2624:v
2506:3
2501:2
2496:1
2261:/
2257:/
2248:/
2244:/
2235:/
2231:/
2205:/
2201:/
2192:/
2188:/
2148:e
2141:t
2134:v
2101:.
2079::
2052:.
2030::
2003:.
1975::
1948:.
1923:.
1902:.
1882::
1858:.
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1758:4
1737:.
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1652:5
1616:.
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1561:.
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1440::
1434:9
1413:.
1401::
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1350:.
1340:8
1322:.
1300::
1273:.
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1214:.
1194::
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1112:.
1100::
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1036:.
1012::
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944:.
930::
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