31:
463:(PCV13; for example, Prevnar 13) is used instead. PCV13 replaced PCV7, adding six new serotypes to the vaccine. While this covers only thirteen strains out of more than ninety strains, these thirteen strains caused 80–90 percent of cases of severe pneumococcal disease in the U.S. before introduction of the vaccine, and it is considered to be nearly 100 percent effective against these strains.
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417:
The most common adverse reactions (reported in more than 10% of subjects vaccinated with pneumococcal polysaccharide vaccine in clinical trials) were: pain, soreness or tenderness at the site of injection (60.0%), injection-site swelling or temporary thickening or hardening of the skin (20.3%),
369:
In the United States, pneumococcal vaccine, polyvalent is indicated for active immunization for the prevention of pneumococcal disease caused by the 23 serotypes contained in the vaccine (1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19F, 19A, 20, 22F, 23F, and 33F). It is
360:
championed the manufacture and distribution of a 14-valent pneumococcal polysaccharide vaccine. This evolved in 1983 to a 23-valent formulation (PPSV23). A significant breakthrough affecting the burden of pneumococcal disease was the licensing of a protein conjugate heptavalent vaccine (PCV7)
820:
Kim NH, Lee J, Lee SJ, Lee H, Kim KH, Park SE, et al. (November 2007). "Immunogenicity and safety of pneumococcal 7-valent conjugate vaccine (diphtheria CRM(197) protein conjugate; Prevenar ) in Korean infants: differences that are found in Asian children".
374:(WHO) recommendations are similar. The WHO does not recommend use of pneumococcal polysaccharide vaccine in routine childhood immunization programs. The recommendations in the UK are similar, but include people with occupational hazards.
396:
to 244 per 100,000 patient–years. Because of the low level of evidence for benefit, 2008 WHO guidelines do not recommend routine immunization with PPV-23 for HIV patients, and suggests preventing pneumococcal disease indirectly with
1280:
447:
1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, and 33F), and so covers 90 percent of the types found in pneumococcal
1084:
190:
760:
Austrian R, Douglas RM, Schiffman G, Coetzee AM, Koornhof HJ, Hayden-Smith S, et al. (1976). "Prevention of pneumococcal pneumonia by vaccination".
478:) require additional protection using the PCV13, with the more extensive PPSV-23 given after the second year of life or two months after the PCV13 dose:
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approved for use in people 50 years of age or older and people aged two years of age or older who are at increased risk for pneumococcal disease. The
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Children under the age of two years fail to mount an adequate response to the 23-valent adult vaccine, and instead a 13-valent
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First used in 1945, the tetravalent vaccine was not widely distributed, since its deployment coincided with the discovery of
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The 23-valent vaccine (for example, Pneumovax 23) is effective against 23 different pneumococcal capsular types (
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392:, the vaccine has been reported to decrease the incidence of invasive pneumococcal disease from 768 per 100,000
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1650:
460:
1026:
1843:
1548:
1242:
World Health
Organization (2008). "23-valent pneumococcal polysaccharide vaccine : WHO position paper".
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World Health
Organization (2008). "23-valent pneumococcal polysaccharide vaccine : WHO position paper".
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558:
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1965:
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662:"The persisting burden of invasive pneumococcal disease in HIV patients: an observational cohort study"
1064:– information on the disease and the Prevnar vaccine, from the Victoria State (Australia) government.
2015:
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713:"Prevention of Pneumococcal Pneumonia by Immunization with Specific Capsular Polysaccharides"
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that is used for the prevention of pneumococcal disease caused by the 23 serotypes of
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The immunological basis for immunization series: module 12: pneumococcal vaccines
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349:. The pneumococcal polysaccharide vaccine is widely used in high-risk adults.
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559:"Pneumococcal 23-polyvalent vaccine (Pneumovax 23) Use During Pregnancy"
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92:
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Macleod CM, Hodges RG, Heidelberger M, Bernhard WG (November 1945).
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The pneumococcal polysaccharide vaccine is important for those with
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1900:
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805:
788:
598:"Pneumovax 23- pneumococcal vaccine polyvalent injection, solution"
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Pneumococcal vaccine may be beneficial to control exacerbations of
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134:
1905:
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This article incorporates text from this source, which is in the
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409:(CDC) recommends immunization in all patients infected with HIV.
38:
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30:
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The polysaccharide antigens were used to induce type-specific
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1689:
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538:
Single dose after second year of life, 2 months after PCV13
438:
1498:
1291:"Pneumococcal Polysaccharide Vaccine Information Statement"
1230:
Manual for the surveillance of vaccine-preventable diseases
1201:
Epidemiology and
Prevention of Vaccine-Preventable Diseases
1102:
977:"Pneumococcal vaccination and chronic respiratory diseases"
484:
Vaccination schedule for children at special risk in the UK
266:
1105:"Vaccines for preventing pneumococcal infection in adults"
324:. It is given by intramuscular or subcutaneous injection.
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1223:
Roush SW, Baldy LM, Hall MA, eds. (9 January 2020).
1193:
1103:
Moberley S, Holden J, Tatham DP, Andrews RM (2013).
660:
Siemieniuk RA, Gregson DB, Gill MJ (November 2011).
928:"World Health Organization. Pneumococcal vaccines"
882:
620:
618:
551:
2361:Cedillo v. Secretary of Health and Human Services
857:"Pneumococcal Vaccination - What You Should Know"
655:
653:
626:"Pneumovax 23 - Pneumococcal Vaccine, Polyvalent"
2481:
1083:. Public Health England. 2013. Gateway 2017624.
974:
615:
1222:
650:
1321:
1194:Hamborsky J, Kroger A, Wolfe S, eds. (2015).
1146:World Health Organization (September 2009).
819:
786:
138:
954:"Who should have the pneumococcal vaccine?"
813:
1328:
1314:
1297:Centers for Disease Control and Prevention
1235:Centers for Disease Control and Prevention
1206:Centers for Disease Control and Prevention
1075:"Pneumococcal: the green book, chapter 25"
1034:Centers for Disease Control and Prevention
862:Centers for Disease Control and Prevention
407:Centers for Disease Control and Prevention
29:
1255:
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1128:
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1002:
992:
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439:Adults and children over two years of age
1027:"Pneumococcal Vaccine Timing for Adults"
537:
527:
522:
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48:23 serotypes of Streptococcus pneumoniae
1204:(13th ed.). Washington D.C.: U.S.
1186:Immunisation against infectious disease
1080:Immunisation against infectious disease
433:
111:
2482:
1178:
1087:from the original on 12 November 2019.
388:. In Canadian patients infected with
1309:
870:from the original on 12 November 2019
379:chronic obstructive pulmonary disease
229:
129:
97:
717:The Journal of Experimental Medicine
528:Further dose in second year of life
202:
306:Pneumococcal polysaccharide vaccine
274:
23:Pneumococcal polysaccharide vaccine
13:
2388:Eradication of infectious diseases
2145:Androvax (androstenedione albumin)
1196:"Chapter 17: Pneumococcal Disease"
1095:
975:Froes F, Roche N, Blasi F (2017).
636:. 28 October 2021. STN BLA 101094.
476:those without a functioning spleen
14:
2501:
1978:Respiratory syncytial virus (RSV)
1274:
454:
418:headache (17.6%), injection-site
412:
161:
2467:
2455:
2367:Alternative vaccination schedule
1337:Artificial induction of immunity
638:
470:Children at special risk (e.g.,
1048:
1019:
981:Int J Chron Obstruct Pulmon Dis
968:
946:
920:
461:pneumococcal conjugated vaccine
364:
140:Pneumococcal vaccine polyvalent
2199:Ovandrotone albumin (Fecundin)
1179:Ramsay M, ed. (January 2018).
1121:10.1002/14651858.CD000422.pub3
1055:Childhood Pneumococcal Disease
849:
780:
753:
704:
1:
1730:Group B streptococcal disease
1549:Vaccines for Children Program
835:10.1016/j.vaccine.2007.08.022
787:Klein JO, Plotkin SA (2007).
544:
399:trimethoprim–sulfamethoxazole
789:"Robert Austrian: 1917-2007"
632:Food and Drug Administration
532:
519:
516:
504:
499:
494:
489:
361:beginning in February 2000.
320:contained in the vaccine as
308:, sold under the brand name
7:
345:(pneumococcal) bacteria by
10:
2506:
1225:"Chapter 11: Pneumococcal"
1181:"Chapter 25: Pneumococcal"
1109:Cochrane Database Syst Rev
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2109:
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1284:World Health Organization
1152:World Health Organization
426:and fatigue (13.2%), and
372:World Health Organization
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1725:Clostridioides difficile
1189:. Public Health England.
679:10.1186/1471-2334-11-314
523:2 doses, 2 months apart
342:Streptococcus pneumoniae
322:capsular polysaccharides
318:Streptococcus pneumoniae
1988:Tick-borne encephalitis
1060:25 October 2006 at the
666:BMC Infectious Diseases
347:phagocytic immune cells
2398:List of vaccine topics
1393:Mathematical modelling
449:bloodstream infections
2393:Vaccinate Your Family
1844:Japanese encephalitis
401:chemoprophylaxis and
2276:John Franklin Enders
1281:Pneumococcal Disease
1244:Wkly. Epidemiol. Rec
994:10.2147/COPD.S140378
894:Wkly. Epidemiol. Rec
729:10.1084/jem.82.6.445
434:Vaccination schedule
314:pneumococcal vaccine
83:PPSV, PPV-23, PPSV23
1457:Virus-like particle
1381:Vaccine ingredients
866:. 6 December 2017.
486:
472:sickle cell disease
467:Special risk-groups
39:Vaccine description
25:
2433:Never to phase III
2232:Hexavalent vaccine
2046:Epstein–Barr virus
1941:Oxford–AstraZeneca
1629:NmVac4-A/C/Y/W-135
482:
21:
2443:
2442:
2355:Vaccines and SIDS
2242:
2241:
2016:Hepatitis A and B
1992:Varicella zoster
1449:Subunit/component
829:(45): 7858–7865.
542:
541:
405:. While the U.S.
339:, and killing of
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302:
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16:Pneumonia vaccine
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2471:
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2334:MMR autism fraud
2281:Maurice Hilleman
2266:Hilary Koprowski
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930:. Archived from
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565:. 7 October 2019
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520:2 Ă— monthly dose
517:3 Ă— monthly dose
487:
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356:. In the 1970s,
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2423:Clinical trials
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2286:Stanley Plotkin
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2150:Cancer vaccines
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2127:Schistosomiasis
2105:
2099:Trypanosomiasis
2072:
2036:Cytomegalovirus
1946:Pfizer–BioNTech
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1514:Vaccine wastage
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1334:
1301:. October 2019.
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1172:
1115:(1): CD000422.
1098:
1096:Further reading
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1062:Wayback Machine
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1036:. 16 March 2020
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934:on 6 March 2002
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1275:External links
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1250:(42): 373–84.
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1233:. Atlanta GA:
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2306:Drew Weissman
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2291:H. Fred Clark
2289:
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2262:
2261:Louis Pasteur
2259:
2257:
2256:Edward Jenner
2254:
2253:
2251:
2245:
2233:
2230:
2228:
2227:DTwP-HepB-Hib
2225:
2223:
2222:DTaP-IPV-HepB
2220:
2218:
2215:
2214:
2213:combination:
2212:
2210:
2207:
2205:
2202:
2200:
2197:
2195:
2192:
2188:
2185:
2181:
2178:
2176:
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2168:
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2140:
2136:
2128:
2125:
2123:
2120:
2119:
2117:
2116:
2114:
2112:
2111:Helminthiasis
2108:
2100:
2097:
2096:
2094:
2090:
2087:
2086:
2085:
2082:
2081:
2079:
2075:
2067:
2064:
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2057:
2054:
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2042:
2039:
2037:
2034:
2033:
2031:
2027:
2024:
2022:
2019:
2017:
2014:
2013:
2012:combination:
2011:
2009:
2006:
2002:
1999:
1997:
1994:
1993:
1991:
1989:
1986:
1984:
1981:
1979:
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1972:
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1964:
1962:
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1744:
1736:
1733:
1731:
1728:
1726:
1723:
1722:
1720:
1716:
1713:
1711:
1710:DPT/DTwP/DTaP
1708:
1707:
1706:combination:
1705:
1703:
1700:
1696:
1693:
1691:
1688:
1687:
1686:
1683:
1679:
1676:
1675:
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1644:
1642:
1639:
1637:
1634:
1630:
1627:
1625:
1622:
1621:
1620:
1619:Meningococcus
1617:
1615:
1612:
1610:
1609:Leptospirosis
1607:
1605:
1602:
1600:
1597:
1595:
1592:
1590:
1587:
1585:
1582:
1581:
1579:
1575:
1572:
1568:
1560:
1557:
1555:
1552:
1550:
1547:
1545:
1544:Vaccine court
1542:
1540:
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1530:
1527:
1525:
1522:
1520:
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1500:
1499:GAVI Alliance
1497:
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645:public domain
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227:
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205:
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188:
185:
184:Intramuscular
182:
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174:
168:
159:
158:
156:
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141:
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127:
126:
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122:
118:
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110:
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104:
100:
96:
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90:
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65:Clinical data
63:
60:
57:
55:
51:
47:
43:
40:
36:
32:
27:
19:
2383:Epidemiology
2359:
2331:
2217:DTaP-IPV/Hib
2008:Yellow fever
1921:EpiVacCorona
1673:Tuberculosis
1655:
1646:Pneumococcal
1614:Lyme disease
1442:Heterologous
1341:Immunization
1294:
1257:10665/241217
1247:
1243:
1229:
1200:
1185:
1147:
1112:
1108:
1079:
1069:
1050:
1038:. Retrieved
1033:
1021:
984:
980:
970:
958:. Retrieved
948:
936:. Retrieved
932:the original
922:
906:10665/241217
897:
893:
872:. Retrieved
860:
851:
826:
822:
815:
796:
792:
782:
765:
761:
755:
720:
716:
706:
669:
665:
629:
605:. Retrieved
601:
567:. Retrieved
562:
553:
533:
512:
506:12–23 months
505:
500:
495:
490:
483:
458:
442:
416:
394:person–years
383:
376:
368:
365:Medical uses
351:
340:
337:phagocytosis
333:opsonization
326:
317:
310:Pneumovax 23
309:
305:
304:
293:
287:
221:Legal status
215:Legal status
121:License data
75:Pneumovax 23
54:Vaccine type
18:
2419:from market
2315:Controversy
2249:researchers
2165:Hepatitis B
2051:Hepatitis C
1996:Chicken pox
1822:Hepatitis E
1817:Hepatitis B
1812:Hepatitis A
1758:Chikungunya
1735:Shigellosis
1589:Brucellosis
1475:Therapeutic
1429:Inactivated
1369:Development
1357:Inoculation
1349:Vaccination
1161:10665/44135
956:. NHS. 2019
874:11 November
768:: 184–194.
501:7–11 months
428:muscle pain
245:Identifiers
107:MedlinePlus
80:Other names
71:Trade names
2350:Thiomersal
2296:Paul Offit
2271:Jonas Salk
2247:Inventors/
2118:research:
2095:research:
2032:research:
1961:Skycovione
1951:Sanofi–GSK
1896:SARS-CoV-2
1807:Hantavirus
1768:rVSV-ZEBOV
1753:Adenovirus
1721:research:
1599:Diphtheria
1437:Attenuated
607:11 January
545:References
496:2–6 months
354:penicillin
329:antibodies
251:ChemSpider
2429:Phase III
2417:Withdrawn
2345:Pox party
2155:ALVAC-CEA
2077:Protozoan
1966:Sputnik V
1916:CoronaVac
1886:Rotavirus
1784:Pandemrix
1636:Pertussis
1577:Bacterial
1461:Synthetic
1424:Conjugate
1376:Adjuvants
1353:Infection
960:7 October
563:Drugs.com
445:serotypes
430:(11.9%).
422:(16.4%),
177:Routes of
151:Pregnancy
99:Monograph
93:Drugs.com
2490:Vaccines
2484:Category
2462:Medicine
2187:Prostvac
2180:Gardasil
2175:Cervarix
2122:Hookworm
2001:Shingles
1983:Smallpox
1901:Corbevax
1837:Gardasil
1832:Cervarix
1570:Vaccines
1524:Schedule
1495:Global:
1403:Timeline
1345:Vaccines
1266:18927997
1139:23440780
1085:Archived
1058:Archived
1013:29255353
914:18927997
868:Archived
843:17931753
747:19871511
698:22078162
602:DailyMed
424:weakness
386:HIV/AIDS
381:(COPD).
296:(verify)
191:ATC code
166: B2
153:category
135:DailyMed
2474:Viruses
2448:Portals
2376:Related
2322:General
2084:Malaria
1971:Valneva
1936:Novavax
1931:Moderna
1926:Janssen
1911:CanSino
1891:Rubella
1849:Measles
1715:Td/Tdap
1685:Typhoid
1668:Tetanus
1663:Q fever
1594:Cholera
1584:Anthrax
1453:Peptide
1417:Classes
1398:Storage
1208:(CDC).
1154:(WHO).
1130:7045867
1040:14 July
1004:5723118
823:Vaccine
799:: 2–3.
738:2135567
689:3226630
672:: 314.
569:14 July
534:PPSV-23
420:redness
312:, is a
207:)
201: (
199:J07AL01
137::
113:a607022
2412:WHO-EM
2332:Lancet
2209:TA-NIC
2194:NicVAX
2041:Dengue
1881:Rabies
1702:Typhus
1641:Plague
1519:Policy
1480:Toxoid
1408:Trials
1264:
1237:(CDC).
1212:
1168:
1137:
1127:
1011:
1001:
938:29 May
912:
841:
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745:
735:
696:
686:
276:D08776
236:â„ž-only
234:
133:
45:Target
2340:NCVIA
2204:TA-CD
2138:Other
2089:RTS,S
1869:Sabin
1864:Polio
1859:Mumps
1763:Ebola
1746:Viral
1695:ViCPS
1690:Ty21a
1624:MeNZB
1554:VAERS
1504:NITAG
1433:Live
1299:(CDC)
1295:U.S.
1286:(WHO)
1030:(PDF)
864:(CDC)
774:14433
634:(FDA)
630:U.S.
513:PCV13
2066:Zika
2026:MMRV
1874:Salk
1854:Mpox
1800:LAIV
1795:H5N8
1790:H5N1
1780:H1N1
1656:PPSV
1539:ACIP
1535:US:
1509:SAGE
1470:mRNA
1386:list
1262:PMID
1210:ISBN
1166:ISBN
1135:PMID
1042:2020
1009:PMID
962:2020
940:2009
910:PMID
876:2019
839:PMID
770:PMID
743:PMID
694:PMID
609:2022
571:2020
474:and
267:KEGG
258:none
89:AHFS
2327:MMR
2170:HPV
2160:BCG
2061:HIV
2021:MMR
1827:HPV
1775:Flu
1678:BCG
1651:PCV
1604:Hib
1559:VSD
1466:DNA
1361:J07
1252:hdl
1156:hdl
1125:PMC
1117:doi
999:PMC
989:doi
902:hdl
831:doi
801:doi
733:PMC
725:doi
684:PMC
674:doi
491:Age
390:HIV
204:WHO
2486::
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