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Polyomaviridae

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329: 69: 1507:. The reactivation of polyomavirus in the kidneys and urinary tract causes the shedding of infected cells, virions, and/or viral proteins in the urine. This allows urine cytology to examine these cells, which if there is polyomavirus inclusion of the nucleus, is diagnostic of infection. Also as the urine of an infected individual will contain virions and/or viral DNA, quantitation of the viral load can be done through PCR. This is also true for the blood. 401: 262: 44: 537:, present oncogenic potential. Several mechanisms have been described for regulating the transition from early to late gene expression, including the involvement of the LT protein in repressing the early promoter, the expression of un-terminated late mRNAs with extensions complementary to early mRNA, and the expression of regulatory 1514:
Tissue staining using a monoclonal antibody against MCV T antigen shows utility in differentiating Merkel cell carcinoma from other small, round cell tumors. Blood tests to detect MCV antibodies have been developed and show that infection with the virus is widespread although Merkel cell carcinoma
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Renal biopsy can also be used if the two methods just described are inconclusive or if the specific viral load for the renal tissue is desired. Similarly to the urine cytology, the renal cells are examined under light microscopy for polyomavirus inclusion of the nucleus, as well as cell lysis and
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The diagnosis of polyomavirus almost always occurs after the primary infection as it is either asymptomatic or sub-clinical. Antibody assays are commonly used to detect presence of antibodies against individual viruses. Competition assays are frequently needed to distinguish among highly similar
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Description of additional viruses is ongoing. These include the sea otter polyomavirus 1 and Alpaca polyomavirus Another virus is the giant panda polyomavirus 1. Another virus has been described from sigmodontine rodents. Another - tree shrew polyomavirus 1 - has been described in the tree shrew.
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plays a key role in regulating the viral life cycle by binding to the viral origin of DNA replication where it promotes DNA synthesis. Also as the polyomavirus relies on the host cell machinery to replicate the host cell needs to be in s-phase for this to begin. Due to this, large T-antigen also
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The details of transit to the nucleus are not clear and may vary among individual polyomaviruses. It has been frequently reported that an intact, albeit distorted, virion particle is released from the endoplasmic reticulum into the cell cytoplasm, where the genome is released from the capsid,
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LT does not. LT induces DNA replication from the viral genome's non-coding control region (NCCR), after which expression of the early mRNA is reduced and expression of the late mRNA, which encodes the viral capsid proteins, begins. As these interactions begin, the LTs belonging to several
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All the polyomaviruses are highly common childhood and young adult infections. Most of these infections appear to cause little or no symptoms. These viruses are probably lifelong persistent among almost all adults. Diseases caused by human polyomavirus infections are most common among
579:(pRB) family, and stimulating cell growth pathways by binding cellular DNA, ATPase-helicase, DNA polymerase α association, and binding of transcription preinitiation complex factors. This abnormal stimulation of the cell cycle is a powerful force for oncogenic transformation. 1398:
contains only the four human viruses shown in the above table. The Alpha and Beta groups contain viruses that infect a variety of mammals. The Gamma group contains the avian viruses. Clinically significant disease associations are shown only where causality is expected.
1559:, after whom it was once called "SE polyoma". The term "polyoma" refers to the viruses' ability to produce multiple (poly-) tumors (-oma) under certain conditions. The name has been criticized as a "meatless linguistic sandwich" ("meatless" because both 1494:
In cases of progressive multifocal leucoencephalopathy (PML), a cross-reactive antibody to SV40 T antigen (commonly Pab419) is used to stain tissues directly for the presence of JC virus T antigen. PCR can be used on a biopsy of the tissue or
415:, many water-mediated, is shown at the binding surface by orange lines, with participating protein residues shown as sticks. Mutations of the two residues shown in cyan at the bottom of the figure can significantly affect pathogenicity. From 1523:
The JC virus offers a promising genetic marker for human evolution and migration. It is carried by 70–90 percent of humans and is usually transmitted from parents to offspring. This method does not appear to be reliable for tracing the
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The current ICTV classification system recognises six genera and 117 species, of which five could not be assigned a genus. This system retains the distinction between avian and mammalian viruses, grouping the avian subset into the genus
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modulates cellular signaling pathways to stimulate progression of the cell cycle by binding to a number of cellular control proteins. This is achieved by a two prong attack of inhibiting tumor suppressing genes p53 and members of the
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in "polyoma" are affixes) giving little insight into the viruses' biology; in fact, subsequent research has found that most polyomaviruses rarely cause clinically significant disease in their host organisms under natural conditions.
686:. It is essential for proliferation in the viruses that express it and is thought to be involved in regulating the viral life cycle, particularly replication and viral exit from the host cell, but the exact mechanisms are unclear. 541:. Expression of the late genes results in accumulation of the viral capsid proteins in the host cell cytoplasm. Capsid components enter the nucleus in order to encapsidate new viral genomic DNA. New virions may be assembled in 1461:
without causing disease, but can cause cancer in rodents under laboratory conditions. In the 1950s and early 1960s, well over 100 million people may have been exposed to SV40 due to previously undetected SV40 contamination of
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The polyomaviruses are members of group I (dsDNA viruses). The classification of polyomaviruses has been the subject of several proposed revisions as new members of the group are discovered. Formerly, polyomaviruses and
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Gonçalves Motta Maia F, Marciel de Souza W, Sabino-Santos G, Jorge Fumagalli M, Modha S, Ramiro Murcia P, Tadeu Moraes Figueiredo L (2018). "A novel polyomavirus in sigmodontine rodents from São Paulo State, Brazil".
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There are three main diagnostic techniques used for the diagnosis of the reactivation of polyomavirus in polyomavirus nephropathy (PVN): urine cytology, quantification of the viral load in both urine and blood, and a
873:(TSV) is distantly related to MCV. Two viruses—HPyV6 and HPyV7—are most closely related to KI and WU viruses, while HPyV9 is most closely related to the African green monkey-derived lymphotropic polyomavirus (LPV). 3382:
Siqueira JD, Ng TF, Miller M, Li L, Deng X, Dodd E, Batac F, Delwart E (July 2017). "Endemic infection of stranded southern sea otters (Enhydra lutris nereis) with novel parvovirus, polyomavirus, and adenovirus".
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Shuda M, Arora R, Kwun HJ, Feng H, Sarid R, Fernández-Figueras MT, Tolstov Y, Gjoerup O, Mansukhani MM, Swerdlow SH, Chaudhary PM, Kirkwood JM, Nalesnik MA, Kant JA, Weiss LM, Moore PS, Chang Y (September 2009).
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Pallas DC, Shahrik LK, Martin BL, Jaspers S, Miller TB, Brautigan DL, Roberts TM (January 1990). "Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A".
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Most polyomaviruses do not infect humans. Of the polyomaviruses cataloged as of 2017, a total of 14 were known with human hosts. However, some polyomaviruses are associated with human disease, particularly in
520:, when the host cell's genome is replicated - because host cell DNA replication machinery is needed for viral genome replication. The precise mechanism of this dysregulation depends on the virus; for example, 4997:
Drews K, Bashir T, Dörries K (January 2000). "Quantification of human polyomavirus JC in brain tissue and cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy by competitive PCR".
465:. However, in general virus-cell interactions are mediated by commonly occurring molecules on the cell surface, and therefore are likely not a major contributor to individual viruses' observed cell-type 827: 841: 820: 3607:
Gheit T, Dutta S, Oliver J, Robitaille A, Hampras S, Combes JD, McKay-Chopin S, Le Calvez-Kelm F, Fenske N, Cherpelis B, Giuliano AR, Franceschi S, McKay J, Rollison DE, Tommasino M (2017).
848: 1482:, accurate detection is often confounded by high levels of cross-reactivity for SV40 with widespread human polyomaviruses. Most virologists dismiss SV40 as a cause for human cancers. 233:, have been identified in humans to a lesser extent. Most of these viruses are very common and typically asymptomatic in most human populations studied. BK virus is associated with 4168:
Ho J, Jedrych JJ, Feng H, Natalie AA, Grandinetti L, Mirvish E, Crespo MM, Yadav D, Fasanella KE, Proksell S, Kuan SF, Pastrana DV, Buck CB, Shuda Y, Moore PS, Chang Y (May 2015).
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Gheit, Tarik; Dutta, Sankhadeep; Oliver, Javier; Robitaille, Alexis; Hampras, Shalaka; Combes, Jean-Damien; McKay-Chopin, Sandrine; Calvez-Kelm, Florence Le; Fenske, Neil (2017).
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Drachenberg CB, Hirsch HH, Ramos E, Papadimitriou JC (December 2005). "Polyomavirus disease in renal transplantation: review of pathological findings and diagnostic methods".
834: 336:, a human polyomavirus. The early region is shown on the left and contains the TAg (tumor antigen) proteins; the late region is on the right and contains the capsid proteins. 1668: 4032:
Padgett BL, Walker DL, ZuRhein GM, Eckroade RJ, Dessel BH (June 1971). "Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy".
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Gossai A, Waterboer T, Nelson HH, Michel A, Willhauck-Fleckenstein M, Farzan SF, Hoen AG, Christensen BC, Kelsey KT, Marsit CJ, Pawlita M, Karagas MR (January 2016).
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protein is also able to activate several cellular pathways that stimulate cell proliferation. Polyomavirus small T antigens commonly target protein phosphatase 2A (
2720:"The T/t common exon of simian virus 40, JC, and BK polyomavirus T antigens can functionally replace the J-domain of the Escherichia coli DnaJ molecular chaperone" 1466:, prompting concern about the possibility that the virus might cause disease in humans. Although it has been reported as present in some human cancers, including 1567:
Dozens of polyomaviruses have been identified and sequenced as of 2017, infecting mainly birds and mammals. Two polyomaviruses are known to infect fish, the
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Antibodies to the monkey lymphotropic polyomavirus have been detected in humans suggesting that this virus - or a closely related virus - can infect humans.
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start sites. Additional genes and other variations on this theme are present in some viruses: for example, rodent polyomaviruses have a third protein called
321:, which is capable of self-assembly into a closed icosahedron; each pentamer of VP1 is associated with one molecule of one of the other two capsid proteins, 191: 756: 5624:"Concurrence of Iridovirus, Polyomavirus, and a Unique Member of a New Group of Fish Papillomaviruses in Lymphocystis Disease-Affected Gilthead Sea Bream" 8015: 4431:
Lim ES, Reyes A, Antonio M, Saha D, Ikumapayi UN, Adeyemi M, Stine OC, Skelton R, Brennan DC, Mkakosya RS, Manary MJ, Gordon JI, Wang D (February 2013).
801: 787: 721:(that is, genetically related groups): the SV40 clade, the avian clade, and the murine polyomavirus clade. A subsequent proposed reclassification by the 198: 184: 348:
regions called the early and late regions due to the time during infection in which they are transcribed. Each region is transcribed by the host cell's
8489: 808: 780: 205: 177: 9066: 8588: 7783: 6062: 870: 8885: 8553: 8496: 8468: 8440: 8110: 7794: 7725: 6985: 6978: 6069: 6027: 6020: 2923:"Merkel cell polyomavirus small T antigen controls viral replication and oncoprotein expression by targeting the cellular ubiquitin ligase SCFFbw7" 5272:
Carter JJ, Paulson KG, Wipf GC, Miranda D, Madeleine MM, Johnson LG, Lemos BD, Lee S, Warcola AH, Iyer JG, Nghiem P, Galloway DA (November 2009).
3558:"Detection and genome characterization of two novel papillomaviruses and a novel polyomavirus in tree shrew (Tupaia belangeri chinensis) in China" 3124:"Infection by agnoprotein-negative mutants of polyomavirus JC and SV40 results in the release of virions that are mostly deficient in DNA content" 9626: 9080: 8934: 8461: 8454: 7274: 6090: 6076: 6034: 5174:"Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays" 2616:
White MK, Gordon J, Reiss K, Del Valle L, Croul S, Giordano A, Darbinyan A, Khalili K (December 2005). "Human polyomaviruses and brain tumors".
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Busam KJ, Jungbluth AA, Rekthman N, Coit D, Pulitzer M, Bini J, Arora R, Hanson NC, Tassello JA, Frosina D, Moore P, Chang Y (September 2009).
722: 3238:"IARC Working Group on the Evaluation of Carcinogenic Risk to Humans. Malaria and Some Polyomaviruses (SV40, BK, JC, and Merkel Cell Viruses)" 2312:"Structural and Functional Analysis of Murine Polyomavirus Capsid Proteins Establish the Determinants of Ligand Recognition and Pathogenicity" 545:. The mechanism of viral release from the host cell varies among polyomaviruses; some express proteins that facilitate cell exit, such as the 9639: 8892: 7965: 7958: 3021:"Interaction of polyomavirus internal protein VP2 with the major capsid protein VP1 and implications for participation of VP2 in viral entry" 906: 229:
are primarily mammals and birds. As of 2024, there are eight recognized genera. 14 species are known to infect humans, while others, such as
1525: 5125:"Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomas" 3173:
Saribas AS, Coric P, Hamazaspyan A, Davis W, Axman R, White MK, Abou-Gharbia M, Childers W, Condra JH, Bouaziz S, Safak M (October 2016).
2823:"The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation" 2565:
Rotondo JC, Bononi I, Puozzo A, Govoni M, Foschi V, Lanza G, Gafà R, Gaboriaud P, Touzé FA, Selvatici R, Martini F, Tognon M (July 2017).
699:, which share many structural features but have very different genomic organizations, were classified together in the now-obsolete family 477:- a behavior unique among known non-enveloped viruses - where the viral capsid structure is likely to be disrupted by action of host cell 4433:"Discovery of STL polyomavirus, a polyomavirus of ancestral recombinant origin that encodes a unique T antigen by alternative splicing" 3997:
Gardner SD, Field AM, Coleman DV, Hulme B (June 1971). "New human papovavirus (B.K.) isolated from urine after renal transplantation".
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Nguyen KD, Lee EE, Yue Y, Stork J, Pock L, North JP, Vandergriff T, Cockerell C, Hosler GA, Pastrana DV, Buck CB, Wang RC (May 2017).
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regulating both cellular and viral oncoproteins. Unlike for SV40, the MCV small T antigen directly transforms rodent cells in vitro.
5704: 3687:"Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors" 658:, and in the interior of the capsid each pentamer is associated with one molecule of either VP2 or VP3. Some polyomaviruses, such as 2661:"Polyomavirus-associated Trichodysplasia spinulosa involves hyperproliferation, pRB phosphorylation and upregulation of p16 and p21" 449:
to sialylated glycans on the cell surface. In some particular viruses, additional cell-surface interactions occur; for example, the
272:, colored such that areas of the surface closer to the interior center appear blue and areas further away appear red. Rendered from 9613: 4217:
Toptan T, Yousem SA, Ho J, Matsushima Y, Stabile LP, Fernández-Figueras MT, Bhargava R, Ryo A, Moore PS, Chang Y (February 2016).
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Gross L (June 1953). "A filterable agent, recovered from Ak leukemic extracts, causing salivary gland carcinomas in C3H mice".
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individuals. MCV is highly divergent from the other human polyomaviruses and is most closely related to murine polyomavirus.
3950:"Identification of a novel polyomavirus in a pancreatic transplant recipient with retinal blindness and vasculitic myopathy" 674:
is a small multifunctional phospho-protein found in the late coding part of the genome of some polyomaviruses, most notably
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containing multiple genes. The early region usually codes for two proteins, the small and large tumor antigens, produced by
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Allander T, Andreasson K, Gupta S, Bjerkner A, Bogdanovic G, Persson MA, Dalianis T, Ramqvist T, Andersson B (April 2007).
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Stewart SE, Eddy BE, Borgese N (June 1958). "Neoplasms in mice inoculated with a tumor agent carried in tissue culture".
2567:"Merkel Cell Carcinomas Arising in Autoimmune Disease Affected Patients Treated with Biologic Drugs, Including Anti-TNF" 5330: 3885:
Korup S, Rietscher J, Calvignac-Spencer S, Trusch F, Hofmann J, Moens U, Sauer I, Voigt S, Schmuck R, Ehlers B (2013).
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Watanabe G, Howe A, Lee RJ, Albanese C, Shu IW, Karnezis AN, Zon L, Kyriakis J, Rundell K, Pestell RG (November 1996).
2518:"Comparisons between Murine Polyomavirus and Simian Virus 40 Show Significant Differences in Small T Antigen Function" 2492: 1552: 644: 411:. GT1a is shown in yellow and the VP1 monomer with a white surface and a blue protein backbone. A complex network of 322: 318: 269: 3308:
Johne R, Buck CB, Allander T, Atwood WJ, Garcea RL, Imperiale MJ, Major EO, Ramqvist T, Norkin LC (September 2011).
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Gaynor AM, Nissen MD, Whiley DM, Mackay IM, Lambert SB, Wu G, Brennan DC, Storch GA, Sloots TP, Wang D (May 2007).
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Moens U, Calvignac-Spencer S, Lauber C, Ramqvist T, Feltkamp MC, Daugherty MD, Verschoor EJ, Ehlers B (June 2017).
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to amplify the polyomavirus DNA. This allows not only the detection of polyomavirus but also which sub type it is.
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Qi D, Shan T, Liu Z, Deng X, Zhang Z, Bi W, Owens JR, Feng F, Zheng L, Huang F, Delwart E, Hou R, Zhang W (2017).
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small T antigen encodes a unique domain, called the LT-stabilization domain (LSD), that binds to and inhibits the
3736:"Discovery of a new human polyomavirus associated with trichodysplasia spinulosa in an immunocompromized patient" 3426:
Dela Cruz FN, Li L, Delwart E, Pesavento PA (2017). "A novel pulmonary polyomavirus in alpacas (Vicugna pacos)".
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Tolstov YL, Pastrana DV, Feng H, Becker JC, Jenkins FJ, Moschos S, Chang Y, Buck CB, Moore PS (September 2009).
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Salunke DM, Caspar DL, Garcea RL (September 1986). "Self-assembly of purified polyomavirus capsid protein VP1".
594:, the mitogen-activated protein kinase (MAPK) pathway, and the stress-activated protein kinase (SAPK) pathway. 489:
concentration in the cytoplasm. Both expression of viral genes and replication of the viral genome occur in the
5475:"Glycosaminoglycans and sialylated glycans sequentially facilitate Merkel cell polyomavirus infectious entry" 4818:"Thirty-five year mortality following receipt of SV40- contaminated polio vaccine during the neonatal period" 2972:"Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator" 2363:"Glycosaminoglycans and sialylated glycans sequentially facilitate Merkel cell polyomavirus infectious entry" 4773:
Gazdar AF, Butel JS, Carbone M (December 2002). "SV40 and human tumours: myth, association or causality?".
360:. The late region contains the three capsid structural proteins VP1, VP2, and VP3, produced by alternative 68: 17: 5575:"Genome Sequence of a Fish-Associated Polyomavirus, Black Sea Bass (Centropristis striata) Polyomavirus 1" 3838:"A novel human polyomavirus closely related to the african green monkey-derived lymphotropic polyomavirus" 7504: 5034: 3787:"The trichodysplasia spinulosa-associated polyomavirus: virological background and clinical implications" 3075:"Merkel cell polyomavirus and two previously unknown polyomaviruses are chronically shed from human skin" 478: 9248: 8753: 7827: 3259:
Pérez-Losada M, Christensen RG, McClellan DA, Adams BJ, Viscidi RP, Demma JC, Crandall KA (June 2006).
662:, do not encode or express VP3. The capsid proteins are expressed from the late region of the genome. 9657: 3836:
Scuda N, Hofmann J, Calvignac-Spencer S, Ruprecht K, Liman P, Kühn J, Hengel H, Ehlers B (May 2011).
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van der Meijden E, Janssens RW, Lauber C, Bouwes Bavinck JN, Gorbalenya AE, Feltkamp MC (July 2010).
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Kazem S, van der Meijden E, Wang RC, Rosenberg AS, Pope E, Benoit T, Fleckman P, Feltkamp MC (2014).
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Calvignac-Spencer S, Feltkamp MC, Daugherty MD, Moens U, Ramqvist T, Johne R, Ehlers B (June 2016).
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Randhawa PS, Vats A, Zygmunt D, Swalsky P, Scantlebury V, Shapiro R, Finkelstein S (August 2002).
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Egli A, Infanti L, Dumoulin A, Buser A, Samaridis J, Stebler C, Gosert R, Hirsch HH (March 2009).
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A fourteenth virus has been described. Lyon IARC polyomavirus is related to raccoon polyomavirus.
9690: 9680: 5035:"Polyomavirus infection of renal allograft recipients: from latent infection to manifest disease" 5033:
Nickeleit V, Hirsch HH, Binet IF, Gudat F, Prince O, Dalquen P, Thiel G, Mihatsch MJ (May 1999).
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Carroll-Pankhurst C, Engels EA, Strickler HD, Goedert JJ, Wagner J, Mortimer EA (November 2001).
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Siebrasse EA, Reyes A, Lim ES, Zhao G, Mkakosya RS, Manary MJ, Gordon JI, Wang D (October 2012).
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has an additional capsid protein VP4; some examples have an additional regulatory protein called
369: 3511: 3175:"Emerging From the Unknown: Structural and Functional Features of Agnoprotein of Polyomaviruses" 9527: 4365: 576: 361: 2217:"Identification of a novel polyomavirus from patients with acute respiratory tract infections" 1515:
patients have exceptionally higher antibody responses than asymptomatically infected persons.
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López-Bueno A, Mavian C, Labella AM, Castro D, Borrego JJ, Alcami A, Alejo A (October 2016).
5076:"Quantitation of viral DNA in renal allograft tissue from patients with BK virus nephropathy" 4953: 1511:
viral partials in the extra cellular fluid. The viral load as before is also measure by PCR.
1123: 1036: 474: 389: 4658:"Prevalence of polyomavirus BK and JC infection and replication in 400 healthy blood donors" 2566: 9587: 5731: 4385: 3898: 2875: 2731: 2672: 2092: 1276: 1243: 1003: 609: 502: 365: 357: 63: 328: 8: 8713: 6472: 5947: 5681: 1536: 1496: 583: 571: 529: 498: 494: 404: 385: 290: 266: 5274:"Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinoma" 4389: 3902: 2879: 2735: 2676: 2096: 7031: 6666: 6652: 6244: 5648: 5623: 5599: 5574: 5501: 5474: 5450: 5425: 5371: 5298: 5273: 5249: 5222: 5198: 5173: 5149: 5124: 5105: 4896: 4842: 4817: 4798: 4557: 4532: 4508: 4481: 4457: 4432: 4408: 4373: 4341: 4316: 4292: 4267: 4243: 4218: 4194: 4169: 4145: 4093: 4068: 3974: 3949: 3921: 3886: 3862: 3837: 3818: 3762: 3735: 3711: 3686: 3635: 3608: 3584: 3557: 3538: 3489: 3462: 3408: 3334: 3309: 3285: 3260: 3199: 3174: 3150: 3123: 3099: 3074: 3045: 3020: 2996: 2971: 2947: 2922: 2803: 2695: 2660: 2641: 2542: 2517: 2441: 2416: 2389: 2362: 2338: 2311: 2243: 2216: 2194: 2113: 2080: 2051: 2024: 1997: 1973:"BK polyoma virus infection and renal disease in non-renal solid organ transplantation" 1972: 1901: 1874: 1847: 1822: 1798: 1773: 1617: 1592: 1440: 949: 624: 250: 5011: 4700:
Poulin DL, DeCaprio JA (September 2006). "Is there a role for SV40 in human cancer?".
4368:, Isa P, Phan TG, Martínez MA, de la Luz Sanchez M, Contreras JF, Santos-Preciado JI, 4045: 4010: 3887:"Identification of a novel human polyomavirus in organs of the gastrointestinal tract" 3556:
Liu P, Qiu Y, Xing C, Zhou JH, Yang WH, Wang Q, Li JY, Han X, Zhang YZ, Ge XY (2019).
3463:"A novel polyomavirus from the nasal cavity of a giant panda (Ailuropoda melanoleuca)" 2629: 2484: 2147: 9574: 9188: 8147: 8022: 8001: 7894: 7550: 7208: 6850: 6413: 6006: 5933: 5653: 5604: 5555: 5550: 5525: 5506: 5455: 5406: 5363: 5326: 5303: 5254: 5203: 5154: 5097: 5092: 5075: 5056: 5015: 4979: 4969: 4934: 4888: 4847: 4790: 4755: 4717: 4679: 4638: 4597: 4562: 4513: 4462: 4413: 4346: 4297: 4248: 4199: 4150: 4121:"Human polyomavirus 6 and 7 are associated with pruritic and dyskeratotic dermatoses" 4098: 4049: 4014: 3979: 3926: 3867: 3810: 3767: 3716: 3640: 3589: 3530: 3494: 3443: 3400: 3339: 3290: 3204: 3155: 3104: 3050: 3001: 2952: 2903: 2898: 2863: 2844: 2839: 2822: 2795: 2791: 2759: 2754: 2719: 2700: 2633: 2598: 2547: 2498: 2488: 2446: 2394: 2343: 2248: 2186: 2182: 2118: 2056: 2002: 1950: 1906: 1852: 1803: 1735: 1622: 1572: 1436: 1412: 866: 773: 458: 417: 353: 349: 274: 246: 170: 5375: 5109: 4900: 4170:"Human polyomavirus 7-associated pruritic rash and viremia in transplant recipients" 3822: 3542: 3412: 2645: 2198: 9579: 8978: 8906: 8799: 8374: 8316: 8279: 8008: 7739: 7697: 7645: 7608: 7578: 7539: 7393: 7319: 7176: 6498: 6461: 6435: 6393: 6194: 6184: 5999: 5851: 5822: 5696: 5643: 5635: 5594: 5586: 5545: 5541: 5537: 5496: 5486: 5445: 5437: 5398: 5355: 5293: 5285: 5244: 5234: 5193: 5185: 5144: 5136: 5087: 5046: 5007: 4961: 4926: 4878: 4837: 4829: 4802: 4782: 4747: 4709: 4669: 4628: 4589: 4552: 4548: 4544: 4503: 4493: 4452: 4444: 4403: 4393: 4336: 4328: 4287: 4279: 4238: 4230: 4189: 4181: 4140: 4132: 4088: 4080: 4041: 4006: 3969: 3961: 3916: 3906: 3857: 3849: 3800: 3757: 3747: 3706: 3698: 3630: 3620: 3579: 3569: 3522: 3484: 3474: 3435: 3392: 3329: 3321: 3280: 3272: 3194: 3186: 3145: 3135: 3094: 3086: 3040: 3032: 2991: 2983: 2942: 2934: 2893: 2883: 2834: 2807: 2787: 2749: 2739: 2690: 2680: 2625: 2588: 2578: 2537: 2529: 2480: 2436: 2428: 2384: 2374: 2333: 2323: 2238: 2228: 2178: 2108: 2100: 2046: 2036: 1992: 1984: 1940: 1896: 1886: 1842: 1834: 1793: 1785: 1725: 1715: 1612: 1604: 1424: 1379: 1342: 884:
The following 14 polyomaviruses with human hosts had been identified and had their
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Dalianis T, Hirsch HH (March 2013). "Human polyomaviruses in disease and cancer".
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infected cell—large (blue) cell below-center-left. Urine cytology specimen.
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using host cell machinery. The early genes - comprising at minimum the
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A rendering of an icosahedral viral capsid comprising 72 pentamers of
9600: 9405: 9276: 8810: 8766: 7840: 7517: 7489: 6928: 5768: 5740: 4633: 4616: 3884: 3835: 3258: 2987: 2081:"Clonal integration of a polyomavirus in human Merkel cell carcinoma" 617: 602: 430: 400: 314: 298: 9618: 9521: 1590: 384:
control or regulatory region containing the early and late regions'
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in shape (T=7 symmetry). The capsid is composed of 72 pentameric
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was the first polyomavirus discovered, having been reported by
1458: 885: 590:), a key multisubunit regulator of multiple pathways including 438: 408: 340:
The genome of a typical polyomavirus codes for between 5 and 9
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in the early region, which is extremely efficient at inducing
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expressed from the late region. The genome also contains a
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The polyomavirus capsid consists of one major component,
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strand. These proteins serve to manipulate the host's
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The polyomavirus life cycle begins with entry into a
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Cellular receptors for polyomaviruses are 9414: 9318: 9285: 8845: 8362: 7706: 7654: 7380: 7144: 7040: 7018: 6127: 5987: 5423: 4219:"Survey for human polyomaviruses in cancer" 4210: 4109: 3660:"Virus Is Linked to a Powerful Skin Cancer" 3355: 3353: 3115: 2022: 1332: 1299: 1059: 1026: 8135: 7107: 5777: 5719: 5705: 5615: 5530:Microbiology and Molecular Biology Reviews 5129:The American Journal of Surgical Pathology 4809: 4737: 3061: 2421:Cold Spring Harbor Perspectives in Biology 2405: 1966: 1964: 1875:"Seroepidemiology of human polyomaviruses" 1767: 1765: 1763: 1761: 1759: 1757: 1755: 1753: 1751: 1749: 1433:progressive multifocal leukoencephalopathy 1266: 1233: 1200: 1167: 1159:Progressive multifocal leukoencephalopathy 1132: 1092: 993: 958: 923: 501:(LT) - are expressed first, from a single 243:progressive multifocal leukoencephalopathy 42: 9390: 7617: 5647: 5598: 5549: 5500: 5490: 5466: 5449: 5426:"Characteristics of the SE polyoma virus" 5297: 5248: 5238: 5197: 5148: 5091: 5050: 4882: 4841: 4673: 4632: 4556: 4507: 4497: 4456: 4407: 4397: 4340: 4291: 4242: 4193: 4144: 4092: 3973: 3920: 3910: 3878: 3861: 3804: 3761: 3751: 3710: 3634: 3624: 3600: 3583: 3573: 3488: 3478: 3333: 3301: 3284: 3198: 3149: 3139: 3098: 3044: 3012: 2995: 2946: 2897: 2887: 2838: 2753: 2743: 2694: 2684: 2592: 2582: 2541: 2440: 2414: 2388: 2378: 2337: 2327: 2242: 2232: 2129: 2112: 2067: 2050: 2040: 1996: 1944: 1922: 1920: 1900: 1890: 1846: 1797: 1729: 1719: 1633: 1616: 709:derived from three abbreviations: Pa for 9403: 9274: 9261: 8808: 8764: 7838: 7825: 7515: 5524:Gottlieb KA, Villarreal LP (June 2001). 5517: 5391:Journal of the National Cancer Institute 5278:Journal of the National Cancer Institute 4649: 4308: 4060: 3505: 3419: 3350: 2718:Kelley WL, Georgopoulos C (April 1997). 2018: 2016: 620:system where middle T is coupled to the 399: 327: 260: 8751: 4424: 4161: 4025: 3990: 3549: 2305: 2303: 2276: 2274: 2272: 2270: 2268: 2266: 2264: 2262: 2162: 1961: 1926: 1746: 859: 616:developed to study cancer, such as the 388:, transcriptional start sites, and the 256: 14: 9673: 7502: 4766: 4357: 3944:Mishra N, Pereira M, Rhodes RH, An P, 3937: 3657: 3651: 3454: 2618:Brain Research. 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Microbiology 1654:"ICTV Report Polyomaviridae" 1485: 880:List of human polyomaviruses 835:Sparus aurata polyomavirus 1 7: 9686:Infectious causes of cancer 4621:Reviews in Medical Virology 4594:10.1016/j.virol.2012.12.015 4499:10.1016/j.virol.2017.03.007 4449:10.1016/j.virol.2012.12.005 3626:10.1016/j.virol.2017.03.007 2473:Advances in Cancer Research 2433:10.1101/cshperspect.a013250 915:Clinical correlate (if any) 689: 627:. There it functions as an 10: 9707: 4549:10.6061/clinics/2018/e558s 4137:10.1016/j.jaad.2016.11.035 3091:10.1016/j.chom.2010.05.006 2939:10.1016/j.chom.2013.06.008 2023:Adang L, Berger J (2015). 1927:Jamboti JS (August 2016). 1531: 1450: 533:polyomaviruses, including 396:Replication and life cycle 9534: 9469: 9447: 9399: 9385: 9270: 9256: 9247: 9186: 9090: 9040: 9029: 8992: 8948: 8834: 8797: 8760: 8746: 8701: 8671: 8649: 8638: 8598: 8527: 8414: 8403: 8392: 8351: 8314: 8277: 8244: 8201: 8190: 8179: 8124: 8080: 8043: 7989: 7925: 7882: 7871: 7860: 7834: 7820: 7764: 7684: 7643: 7606: 7548: 7537: 7511: 7497: 7488: 7440: 7369: 7317: 7291: 7262: 7240: 7218: 7196: 7185: 7174: 7133: 7096: 7085: 7074: 7007: 6926: 6915: 6911: 6897: 6768: 6746: 6710: 6699: 6692: 6607: 6573: 6551: 6529: 6507: 6496: 6470: 6459: 6422: 6411: 6367: 6345: 6323: 6312: 6286: 6264: 6253: 6242: 6231: 6220: 6182: 6160: 6116: 5965: 5899: 5877: 5839: 5810: 5766: 5762: 5748: 5739: 5360:10.3181/00379727-83-20376 4822:British Journal of Cancer 4235:10.1172/jci.insight.85562 3575:10.1186/s12985-019-1141-9 3527:10.1007/s00705-018-3913-8 3480:10.1186/s12985-017-0867-5 3326:10.1007/s00705-011-1008-x 1721:10.1007/s00705-016-2794-y 985:Trichodysplasia spinulosa 557:, releasing the virions. 166: 161: 62: 50: 41: 34: 5591:10.1128/genomeA.01476-14 4865:Shah KV (January 2007). 4714:10.1200/JCO.2005.03.7101 3037:10.1093/emboj/17.12.3233 2889:10.1073/pnas.93.23.12861 2571:Clinical Cancer Research 1118:Polyomavirus-associated 934:Merkel cell polyomavirus 660:Merkel cell polyomavirus 641:major capsid protein VP1 596:Merkel cell polyomavirus 535:Merkel cell polyomavirus 485:possibly due to the low 332:Genome structure of the 5442:10.2105/AJPH.49.11.1486 4966:10.1007/0-387-32957-9_5 3428:Veterinary Microbiology 3223:"ICTV Taxonomy Website" 3141:10.1186/1743-422X-8-255 3079:Cell Host & Microbe 2927:Cell Host & Microbe 2105:10.1126/science.1152586 1977:Clinical Kidney Journal 1480:non-Hodgkin's lymphomas 1446: 1373:Lyon IARC polyomavirus 1070:New Jersey polyomavirus 370:cellular transformation 5403:10.1093/jnci/20.6.1223 5323:DNA for Archaeologists 4834:10.1054/bjoc.2001.2065 4775:Nature Reviews. Cancer 2745:10.1073/pnas.94.8.3679 888:sequenced as of 2017: 768:. The six genera are: 426: 337: 309:in diameter, which is 293:viruses with circular 283: 4186:10.1093/infdis/jiu524 3966:10.1093/infdis/jiu250 1366:Human polyomavirus 14 1334:Human polyomavirus 11 1301:Human polyomavirus 10 1124:haemorrhagic cystitis 1061:Human polyomavirus 13 1037:Human polyomavirus 12 1028:Human polyomavirus 12 503:alternatively spliced 475:endoplasmic reticulum 403: 390:origin of replication 331: 264: 5732:virus classification 5640:10.1128/JVI.01369-16 5579:Genome Announcements 5052:10.1681/ASN.V1051080 4956:. In Ahsan N (ed.). 4333:10.1128/JVI.01690-12 4284:10.1128/JVI.01210-12 4085:10.1128/JVI.00028-07 3854:10.1128/jvi.02602-10 3515:Archives of Virology 3314:Archives of Virology 3277:10.1128/JVI.00056-06 2534:10.1128/JVI.05034-11 1708:Archives of Virology 1673:www.ncbi.nlm.nih.gov 1609:10.1099/jgv.0.000839 1547:capable of inducing 1277:Human polyomavirus 7 1268:Human polyomavirus 7 1244:Human polyomavirus 6 1235:Human polyomavirus 6 1202:Human polyomavirus 4 1169:Human polyomavirus 3 1134:Human polyomavirus 2 1094:Human polyomavirus 1 1004:Human polyomavirus 9 995:Human polyomavirus 9 960:Human polyomavirus 8 925:Human polyomavirus 5 860:Human polyomaviruses 610:middle tumor antigen 366:middle tumor antigen 358:alternative splicing 317:of a protein called 257:Structure and genome 64:Virus classification 8714:Permutotetraviridae 6473:Orthopolintovirales 5948:Malacoherpesviridae 5628:Journal of Virology 5290:10.1093/jnci/djp332 4537:Clinics (Sao Paulo) 4390:2012PLoSO...749449Y 4321:Journal of Virology 4272:Journal of Virology 4073:Journal of Virology 3903:2013PLoSO...858021K 3842:Journal of Virology 3397:10.7589/2016-04-082 3265:Journal of Virology 2880:1996PNAS...9312861W 2736:1997PNAS...94.3679K 2677:2014PLoSO...9j8947K 2528:(20): 10649–10658. 2522:Journal of Virology 2097:2008Sci...319.1096F 1790:10.1038/nrmicro2992 1537:Murine polyomavirus 1497:cerebrospinal fluid 795:Epsilonpolyomavirus 584:small tumor antigen 572:large tumor antigen 530:murine polyomavirus 499:large tumor antigen 495:small tumor antigen 479:disulfide isomerase 405:Murine polyomavirus 344:, divided into two 291:double-stranded DNA 286:Polyomaviruses are 267:murine polyomavirus 192:Epsilonpolyomavirus 7032:Malgrandaviricetes 6667:Sphaerolipoviridae 6653:Matshushitaviridae 6245:Nucleocytoviricota 4543:(suppl 1): e558s. 3664:The New York Times 2091:(5866): 1096–100. 1989:10.1093/ckj/sfv143 1839:10.1093/aje/kwv155 1441:Merkel cell cancer 1406:Clinical relevance 950:Merkel cell cancer 757:Avian polyomavirus 427: 338: 284: 251:Merkel cell cancer 9668: 9667: 9528:Taxon identifiers 9519: 9518: 9515: 9514: 9511: 9510: 9507: 9506: 9503: 9502: 9499: 9498: 9495: 9494: 9491: 9490: 9381: 9380: 9377: 9376: 9373: 9372: 9369: 9368: 9365: 9364: 9361: 9360: 9243: 9242: 9239: 9238: 9235: 9234: 9231: 9230: 9227: 9226: 9223: 9222: 9219: 9218: 9189:Yunchangviricetes 9182: 9181: 9025: 9024: 8988: 8987: 8944: 8943: 8830: 8829: 8742: 8741: 8738: 8737: 8734: 8733: 8730: 8729: 8697: 8696: 8693: 8692: 8634: 8633: 8388: 8387: 8384: 8383: 8347: 8346: 8310: 8309: 8273: 8272: 8175: 8174: 8171: 8170: 8148:Carmotetraviridae 8120: 8119: 8076: 8075: 8039: 8038: 8023:Gammaflexiviridae 8016:Deltaflexiviridae 8002:Alphaflexiviridae 7895:Alphatetraviridae 7816: 7815: 7812: 7811: 7808: 7807: 7804: 7803: 7760: 7759: 7756: 7755: 7680: 7679: 7676: 7675: 7639: 7638: 7602: 7601: 7551:Chrymotiviricetes 7484: 7483: 7480: 7479: 7476: 7475: 7436: 7435: 7432: 7431: 7428: 7427: 7424: 7423: 7365: 7364: 7361: 7360: 7357: 7356: 7313: 7312: 7209:Bacilladnaviridae 7170: 7169: 7166: 7165: 7129: 7128: 7070: 7069: 7066: 7065: 7062: 7061: 7003: 7002: 6999: 6998: 6995: 6994: 6893: 6892: 6889: 6888: 6885: 6884: 6851:Portogloboviridae 6764: 6763: 6688: 6687: 6684: 6683: 6680: 6679: 6676: 6675: 6603: 6602: 6599: 6598: 6595: 6594: 6492: 6491: 6455: 6454: 6414:Preplasmiviricota 6407: 6406: 6403: 6402: 6308: 6307: 6216: 6215: 6212: 6211: 6208: 6207: 6204: 6203: 6112: 6111: 6108: 6107: 6104: 6103: 6100: 6099: 6007:Autographiviridae 5961: 5960: 5957: 5956: 5934:Alloherpesviridae 5873: 5872: 5869: 5868: 5865: 5864: 5861: 5860: 5190:10.1002/ijc.24509 4975:978-0-387-29233-5 4884:10.1002/ijc.22425 4752:10.1002/ijc.11517 4131:(5): 932–940.e3. 4040:(7712): 1257–60. 3806:10.1111/apm.12092 3703:10.1002/ijc.24510 3521:(10): 2913–2915. 3191:10.1002/jcp.25329 2577:(14): 3929–3934. 1946:10.1111/nep.12728 1573:gilthead seabream 1437:Merkel cell virus 1413:immunocompromised 1396:Deltapolyomavirus 1393: 1392: 912:Year of discovery 867:immunocompromised 802:Gammapolyomavirus 788:Deltapolyomavirus 774:Alphapolyomavirus 766:Gammapolyomavirus 731:Orthopolyomavirus 459:Merkel cell virus 354:pre-messenger RNA 350:RNA polymerase II 247:Merkel cell virus 214: 213: 199:Gammapolyomavirus 185:Deltapolyomavirus 171:Alphapolyomavirus 27:Family of viruses 16:(Redirected from 9698: 9661: 9660: 9648: 9647: 9635: 9634: 9622: 9621: 9609: 9608: 9596: 9595: 9583: 9582: 9570: 9569: 9568: 9555: 9554: 9553: 9523: 9522: 9445: 9444: 9434: 9433: 9423: 9422: 9412: 9411: 9401: 9400: 9393:dsDNA-RT viruses 9387: 9386: 9316: 9315: 9305: 9304: 9294: 9293: 9283: 9282: 9272: 9271: 9264:ssRNA-RT viruses 9258: 9257: 9254: 9253: 9195: 9194: 9038: 9037: 9006:Serpentovirales 9001: 9000: 8979:Orthomyxoviridae 8957: 8956: 8907:Peribunyaviridae 8843: 8842: 8806: 8805: 8800:Chunqiuviricetes 8795: 8794: 8784: 8783: 8773: 8772: 8762: 8761: 8754:(–)ssRNA viruses 8748: 8747: 8647: 8646: 8490:Nanghoshaviridae 8412: 8411: 8401: 8400: 8375:Botourmiaviridae 8360: 8359: 8323: 8322: 8317:Howeltoviricetes 8286: 8285: 8280:Amabiliviricetes 8199: 8198: 8188: 8187: 8133: 8132: 8089: 8088: 8052: 8051: 8009:Betaflexiviridae 7880: 7879: 7869: 7868: 7858: 7857: 7847: 7846: 7836: 7835: 7828:(+)ssRNA viruses 7822: 7821: 7740:Picobirnaviridae 7704: 7703: 7698:Duplopiviricetes 7693: 7692: 7652: 7651: 7646:Vidaverviricetes 7615: 7614: 7609:Resentoviricetes 7579:Megabirnaviridae 7557: 7556: 7546: 7545: 7540:Duplornaviricota 7535: 7534: 7524: 7523: 7513: 7512: 7499: 7498: 7495: 7494: 7400: 7399: 7394:Huolimaviricetes 7389: 7388: 7378: 7377: 7326: 7325: 7320:Repensiviricetes 7194: 7193: 7183: 7182: 7177:Cressdnaviricota 7142: 7141: 7105: 7104: 7094: 7093: 7083: 7082: 7038: 7037: 7027: 7026: 7016: 7015: 6957: 6956: 6946: 6945: 6935: 6934: 6924: 6923: 6913: 6912: 6899: 6898: 6708: 6707: 6697: 6696: 6638: 6637: 6627: 6626: 6616: 6615: 6505: 6504: 6499:Tectiliviricetes 6468: 6467: 6462:Polintoviricetes 6436:Priklausovirales 6431: 6430: 6420: 6419: 6394:Marseilleviridae 6321: 6320: 6262: 6261: 6251: 6250: 6240: 6239: 6229: 6228: 6195:Papillomaviridae 6185:Zurhausenvirales 6158: 6157: 6147: 6146: 6136: 6135: 6125: 6124: 6000:Ackermannviridae 5985: 5984: 5974: 5973: 5919: 5918: 5908: 5907: 5897: 5896: 5886: 5885: 5852:Tristromaviridae 5823:Lipothrixviridae 5808: 5807: 5797: 5796: 5786: 5785: 5775: 5774: 5764: 5763: 5750: 5749: 5746: 5745: 5721: 5714: 5707: 5698: 5697: 5677:: Polyomaviridae 5662: 5661: 5651: 5619: 5613: 5612: 5602: 5585:(1): e01476-14. 5570: 5564: 5563: 5553: 5521: 5515: 5514: 5504: 5494: 5470: 5464: 5463: 5453: 5421: 5415: 5414: 5386: 5380: 5379: 5343: 5337: 5336: 5318: 5312: 5311: 5301: 5269: 5263: 5262: 5252: 5242: 5218: 5212: 5211: 5201: 5169: 5163: 5162: 5152: 5120: 5114: 5113: 5095: 5071: 5065: 5064: 5054: 5030: 5024: 5023: 4994: 4988: 4987: 4949: 4943: 4942: 4914: 4905: 4904: 4886: 4862: 4856: 4855: 4845: 4813: 4807: 4806: 4770: 4764: 4763: 4735: 4726: 4725: 4697: 4688: 4687: 4677: 4653: 4647: 4646: 4636: 4634:10.1002/rmv.1711 4612: 4606: 4605: 4577: 4571: 4570: 4560: 4528: 4522: 4521: 4511: 4501: 4477: 4471: 4470: 4460: 4428: 4422: 4421: 4411: 4401: 4361: 4355: 4354: 4344: 4312: 4306: 4305: 4295: 4263: 4257: 4256: 4246: 4214: 4208: 4207: 4197: 4165: 4159: 4158: 4148: 4116: 4107: 4106: 4096: 4064: 4058: 4057: 4029: 4023: 4022: 4005:(7712): 1253–7. 3994: 3988: 3987: 3977: 3941: 3935: 3934: 3924: 3914: 3882: 3876: 3875: 3865: 3833: 3827: 3826: 3808: 3782: 3776: 3775: 3765: 3755: 3731: 3725: 3724: 3714: 3681: 3675: 3674: 3672: 3670: 3655: 3649: 3648: 3638: 3628: 3604: 3598: 3597: 3587: 3577: 3553: 3547: 3546: 3509: 3503: 3502: 3492: 3482: 3467:Virology Journal 3458: 3452: 3451: 3423: 3417: 3416: 3379: 3373: 3372: 3370: 3368: 3357: 3348: 3347: 3337: 3305: 3299: 3298: 3288: 3256: 3250: 3249: 3233: 3227: 3226: 3219: 3213: 3212: 3202: 3170: 3164: 3163: 3153: 3143: 3128:Virology Journal 3119: 3113: 3112: 3102: 3070: 3059: 3058: 3048: 3025:The EMBO Journal 3016: 3010: 3009: 2999: 2988:10.1172/JCI46323 2967: 2961: 2960: 2950: 2918: 2912: 2911: 2901: 2891: 2859: 2853: 2852: 2842: 2818: 2812: 2811: 2774: 2768: 2767: 2757: 2747: 2715: 2709: 2708: 2698: 2688: 2656: 2650: 2649: 2613: 2607: 2606: 2596: 2586: 2562: 2556: 2555: 2545: 2513: 2507: 2506: 2468: 2455: 2454: 2444: 2412: 2403: 2402: 2392: 2382: 2358: 2352: 2351: 2341: 2331: 2322:(10): e1005104. 2307: 2298: 2297: 2287: 2278: 2257: 2256: 2246: 2236: 2212: 2203: 2202: 2166: 2160: 2159: 2157: 2155: 2144: 2127: 2126: 2116: 2076: 2065: 2064: 2054: 2044: 2020: 2011: 2010: 2000: 1968: 1959: 1958: 1948: 1924: 1915: 1914: 1904: 1894: 1870: 1861: 1860: 1850: 1818: 1812: 1811: 1801: 1769: 1744: 1743: 1733: 1723: 1699: 1684: 1683: 1681: 1679: 1664: 1658: 1657: 1650: 1631: 1630: 1620: 1603:(6): 1159–1160. 1588: 1491:polyomaviruses. 1425:renal transplant 1343:STL polyomavirus 1336: 1303: 1270: 1237: 1204: 1171: 1136: 1096: 1063: 1030: 997: 962: 927: 891: 890: 809:Zetapolyomavirus 781:Betapolyomavirus 742:Wukipolyomavirus 697:papillomaviruses 651:form the closed 424: 281: 239:renal transplant 206:Zetapolyomavirus 178:Betapolyomavirus 72: 71: 46: 32: 31: 21: 9706: 9705: 9701: 9700: 9699: 9697: 9696: 9695: 9671: 9670: 9669: 9664: 9656: 9651: 9643: 9638: 9630: 9625: 9617: 9612: 9604: 9599: 9591: 9586: 9578: 9573: 9564: 9563: 9558: 9549: 9548: 9543: 9530: 9520: 9487: 9465: 9439:Revtraviricetes 9395: 9357: 9310:Revtraviricetes 9266: 9215: 9178: 9145:Paramyxoviridae 9093:Mononegavirales 9086: 9067:Crepuscuviridae 9021: 8984: 8962:Articulavirales 8951:Insthoviricetes 8940: 8826: 8789:Negarnaviricota 8756: 8726: 8689: 8667: 8641:Stelpaviricetes 8630: 8594: 8589:Polycipiviridae 8582:Dicistroviridae 8523: 8406:Pisoniviricetes 8380: 8343: 8306: 8269: 8240: 8167: 8127:Tolucaviricetes 8116: 8072: 8057:Amarillovirales 8035: 7985: 7945:Closteroviridae 7928:Martellivirales 7921: 7863:Kitrinoviricota 7830: 7800: 7784:Polymycoviridae 7752: 7672: 7635: 7598: 7507: 7472: 7460:Finnlakeviridae 7420: 7415:Pleolipoviridae 7353: 7309: 7287: 7258: 7236: 7214: 7162: 7136:Quintoviricetes 7125: 7058: 6991: 6907: 6881: 6760: 6742: 6672: 6643:Halopanivirales 6591: 6569: 6547: 6525: 6488: 6451: 6425:Maveriviricetes 6399: 6363: 6341: 6336:Phycodnaviridae 6304: 6282: 6256:Pokkesviricetes 6200: 6178: 6152:Papovaviricetes 6096: 6063:Rountreeviridae 5953: 5857: 5835: 5758: 5735: 5725: 5670: 5665: 5634:(19): 8768–79. 5620: 5616: 5571: 5567: 5522: 5518: 5485:(7): e1002161. 5471: 5467: 5436:(11): 1486–92. 5422: 5418: 5387: 5383: 5344: 5340: 5333: 5319: 5315: 5284:(21): 1510–22. 5270: 5266: 5233:(9): e1000578. 5219: 5215: 5170: 5166: 5121: 5117: 5080:Transplantation 5072: 5068: 5031: 5027: 4995: 4991: 4976: 4950: 4946: 4925:(12): 1245–55. 4919:Human Pathology 4915: 4908: 4863: 4859: 4814: 4810: 4771: 4767: 4736: 4729: 4708:(26): 4356–65. 4698: 4691: 4654: 4650: 4613: 4609: 4578: 4574: 4529: 4525: 4478: 4474: 4429: 4425: 4362: 4358: 4313: 4309: 4278:(19): 10321–6. 4264: 4260: 4215: 4211: 4166: 4162: 4117: 4110: 4065: 4061: 4030: 4026: 3995: 3991: 3942: 3938: 3883: 3879: 3834: 3830: 3783: 3779: 3746:(7): e1001024. 3732: 3728: 3682: 3678: 3668: 3666: 3656: 3652: 3605: 3601: 3554: 3550: 3510: 3506: 3459: 3455: 3424: 3420: 3380: 3376: 3366: 3364: 3359: 3358: 3351: 3306: 3302: 3257: 3253: 3234: 3230: 3221: 3220: 3216: 3185:(10): 2115–27. 3171: 3167: 3120: 3116: 3071: 3062: 3031:(12): 3233–40. 3017: 3013: 2968: 2964: 2919: 2915: 2874:(23): 12861–6. 2860: 2856: 2819: 2815: 2775: 2771: 2716: 2712: 2671:(10): e108947. 2657: 2653: 2614: 2610: 2563: 2559: 2514: 2510: 2495: 2469: 2458: 2413: 2406: 2373:(7): e1002161. 2359: 2355: 2308: 2301: 2285: 2279: 2260: 2213: 2206: 2167: 2163: 2153: 2151: 2146: 2145: 2130: 2077: 2068: 2021: 2014: 1969: 1962: 1925: 1918: 1885:(3): e1000363. 1871: 1864: 1819: 1815: 1770: 1747: 1700: 1687: 1677: 1675: 1665: 1661: 1652: 1651: 1634: 1589: 1585: 1581: 1534: 1521: 1488: 1455: 1449: 1408: 1310:MW polyomavirus 1211:WU polyomavirus 1178:KI polyomavirus 1143:JC polyomavirus 1103:BK polyomavirus 882: 862: 753:Avipolyomavirus 746:KI polyomavirus 692: 668: 637: 635:Capsid proteins 614:model organisms 568: 563: 543:viral factories 473:and enters the 463:heparan sulfate 416: 398: 346:transcriptional 305:of about 40-50 297:of around 5000 273: 259: 231:Simian Virus 40 221:is a family of 131:Papovaviricetes 66: 28: 23: 22: 15: 12: 11: 5: 9704: 9694: 9693: 9691:Virus families 9688: 9683: 9681:Polyomaviridae 9666: 9665: 9663: 9662: 9649: 9636: 9623: 9610: 9597: 9584: 9571: 9566:Polyomaviridae 9556: 9540: 9538: 9536:Polyomaviridae 9532: 9531: 9517: 9516: 9513: 9512: 9509: 9508: 9505: 9504: 9501: 9500: 9497: 9496: 9493: 9492: 9489: 9488: 9486: 9485: 9482:Caulimoviridae 9477: 9475: 9467: 9466: 9464: 9463: 9460:Hepadnaviridae 9455: 9453: 9442: 9431: 9428:Artverviricota 9420: 9409: 9397: 9396: 9383: 9382: 9379: 9378: 9375: 9374: 9371: 9370: 9367: 9366: 9363: 9362: 9359: 9358: 9356: 9355: 9348: 9341: 9334: 9326: 9324: 9313: 9302: 9299:Artverviricota 9291: 9280: 9268: 9267: 9251: 9245: 9244: 9241: 9240: 9237: 9236: 9233: 9232: 9229: 9228: 9225: 9224: 9221: 9220: 9217: 9216: 9214: 9213: 9205: 9203: 9200:Goujianvirales 9192: 9184: 9183: 9180: 9179: 9177: 9176: 9169: 9162: 9155: 9148: 9141: 9134: 9127: 9120: 9113: 9106: 9098: 9096: 9088: 9087: 9085: 9084: 9077: 9070: 9063: 9056: 9048: 9046: 9043:Jingchuvirales 9035: 9032:Monjiviricetes 9027: 9026: 9023: 9022: 9020: 9019: 9011: 9009: 8998: 8995:Milneviricetes 8990: 8989: 8986: 8985: 8983: 8982: 8975: 8967: 8965: 8954: 8946: 8945: 8942: 8941: 8939: 8938: 8931: 8924: 8917: 8910: 8903: 8896: 8889: 8886:Leishbuviridae 8882: 8875: 8868: 8861: 8853: 8851: 8840: 8837:Ellioviricetes 8832: 8831: 8828: 8827: 8825: 8824: 8816: 8814: 8803: 8792: 8781: 8770: 8758: 8757: 8744: 8743: 8740: 8739: 8736: 8735: 8732: 8731: 8728: 8727: 8725: 8724: 8721:Sarthroviridae 8717: 8705: 8703: 8699: 8698: 8695: 8694: 8691: 8690: 8688: 8687: 8679: 8677: 8669: 8668: 8666: 8665: 8657: 8655: 8644: 8636: 8635: 8632: 8631: 8629: 8628: 8621: 8614: 8611:Alvernaviridae 8606: 8604: 8596: 8595: 8593: 8592: 8585: 8578: 8571: 8564: 8557: 8554:Solinviviridae 8550: 8543: 8540:Picornaviridae 8535: 8533: 8530:Picornavirales 8525: 8524: 8522: 8521: 8514: 8507: 8500: 8497:Nanhypoviridae 8493: 8486: 8479: 8472: 8469:Medioniviridae 8465: 8458: 8451: 8444: 8441:Cremegaviridae 8437: 8430: 8422: 8420: 8409: 8398: 8390: 8389: 8386: 8385: 8382: 8381: 8379: 8378: 8370: 8368: 8357: 8349: 8348: 8345: 8344: 8342: 8341: 8333: 8331: 8320: 8312: 8311: 8308: 8307: 8305: 8304: 8296: 8294: 8291:Wolframvirales 8283: 8275: 8274: 8271: 8270: 8268: 8267: 8260: 8252: 8250: 8242: 8241: 8239: 8238: 8231: 8224: 8217: 8209: 8207: 8196: 8185: 8177: 8176: 8173: 8172: 8169: 8168: 8166: 8165: 8158: 8151: 8143: 8141: 8130: 8122: 8121: 8118: 8117: 8115: 8114: 8111:Sinhaliviridae 8107: 8099: 8097: 8086: 8083:Magsaviricetes 8078: 8077: 8074: 8073: 8071: 8070: 8062: 8060: 8049: 8046:Flasuviricetes 8041: 8040: 8037: 8036: 8034: 8033: 8026: 8019: 8012: 8005: 7997: 7995: 7987: 7986: 7984: 7983: 7976: 7969: 7962: 7955: 7952:Endornaviridae 7948: 7941: 7933: 7931: 7923: 7922: 7920: 7919: 7912: 7905: 7898: 7890: 7888: 7877: 7866: 7855: 7844: 7832: 7831: 7818: 7817: 7814: 7813: 7810: 7809: 7806: 7805: 7802: 7801: 7799: 7798: 7795:Botybirnavirus 7787: 7780: 7768: 7766: 7762: 7761: 7758: 7757: 7754: 7753: 7751: 7750: 7747:Partitiviridae 7743: 7736: 7729: 7726:Curvulaviridae 7722: 7714: 7712: 7701: 7690: 7682: 7681: 7678: 7677: 7674: 7673: 7671: 7670: 7662: 7660: 7649: 7641: 7640: 7637: 7636: 7634: 7633: 7625: 7623: 7612: 7604: 7603: 7600: 7599: 7597: 7596: 7589: 7582: 7575: 7567: 7565: 7554: 7543: 7532: 7521: 7509: 7508: 7492: 7486: 7485: 7482: 7481: 7478: 7477: 7474: 7473: 7471: 7470: 7463: 7456: 7444: 7442: 7438: 7437: 7434: 7433: 7430: 7429: 7426: 7425: 7422: 7421: 7419: 7418: 7410: 7408: 7397: 7386: 7375: 7367: 7366: 7363: 7362: 7359: 7358: 7355: 7354: 7352: 7351: 7344: 7336: 7334: 7331:Geplafuvirales 7323: 7315: 7314: 7311: 7310: 7308: 7307: 7304:Redondoviridae 7299: 7297: 7289: 7288: 7286: 7285: 7278: 7270: 7268: 7260: 7259: 7257: 7256: 7248: 7246: 7238: 7237: 7235: 7234: 7226: 7224: 7216: 7215: 7213: 7212: 7204: 7202: 7191: 7180: 7172: 7171: 7168: 7167: 7164: 7163: 7161: 7160: 7152: 7150: 7139: 7131: 7130: 7127: 7126: 7124: 7123: 7115: 7113: 7102: 7091: 7080: 7072: 7071: 7068: 7067: 7064: 7063: 7060: 7059: 7057: 7056: 7048: 7046: 7035: 7024: 7013: 7005: 7004: 7001: 7000: 6997: 6996: 6993: 6992: 6990: 6989: 6986:Plectroviridae 6982: 6979:Paulinoviridae 6975: 6967: 6965: 6954: 6951:Faserviricetes 6943: 6940:Hofneiviricota 6932: 6921: 6909: 6908: 6895: 6894: 6891: 6890: 6887: 6886: 6883: 6882: 6880: 6879: 6872: 6861: 6854: 6847: 6844:Polydnaviridae 6840: 6833: 6826: 6819: 6812: 6809:Globuloviridae 6805: 6802:Fuselloviridae 6798: 6791: 6788:Bicaudaviridae 6784: 6781:Ampullaviridae 6772: 6770: 6766: 6765: 6762: 6761: 6759: 6758: 6750: 6748: 6744: 6743: 6741: 6740: 6733: 6730:Hytrosaviridae 6726: 6718: 6716: 6705: 6702:Naldaviricetes 6694: 6690: 6689: 6686: 6685: 6682: 6681: 6678: 6677: 6674: 6673: 6671: 6670: 6663: 6656: 6648: 6646: 6635: 6632:Laserviricetes 6624: 6621:Dividoviricota 6613: 6605: 6604: 6601: 6600: 6597: 6596: 6593: 6592: 6590: 6589: 6586:Corticoviridae 6581: 6579: 6571: 6570: 6568: 6567: 6559: 6557: 6549: 6548: 6546: 6545: 6537: 6535: 6527: 6526: 6524: 6523: 6515: 6513: 6502: 6494: 6493: 6490: 6489: 6487: 6486: 6478: 6476: 6465: 6457: 6456: 6453: 6452: 6450: 6449: 6441: 6439: 6428: 6417: 6409: 6408: 6405: 6404: 6401: 6400: 6398: 6397: 6390: 6383: 6375: 6373: 6370:Pimascovirales 6365: 6364: 6362: 6361: 6353: 6351: 6343: 6342: 6340: 6339: 6331: 6329: 6318: 6310: 6309: 6306: 6305: 6303: 6302: 6294: 6292: 6284: 6283: 6281: 6280: 6272: 6270: 6259: 6248: 6237: 6226: 6218: 6217: 6214: 6213: 6210: 6209: 6206: 6205: 6202: 6201: 6199: 6198: 6190: 6188: 6180: 6179: 6177: 6176: 6173:Polyomaviridae 6168: 6166: 6155: 6144: 6133: 6122: 6114: 6113: 6110: 6109: 6106: 6105: 6102: 6101: 6098: 6097: 6095: 6094: 6087: 6080: 6073: 6070:Salasmaviridae 6066: 6059: 6052: 6045: 6042:Herelleviridae 6038: 6031: 6028:Drexlerviridae 6024: 6021:Demerecviridae 6017: 6010: 6003: 5995: 5993: 5982: 5979:Caudoviricetes 5971: 5963: 5962: 5959: 5958: 5955: 5954: 5952: 5951: 5944: 5937: 5929: 5927: 5916: 5913:Herviviricetes 5905: 5894: 5891:Heunggongvirae 5883: 5875: 5874: 5871: 5870: 5867: 5866: 5863: 5862: 5859: 5858: 5856: 5855: 5847: 5845: 5837: 5836: 5834: 5833: 5826: 5818: 5816: 5813:Ligamenvirales 5805: 5794: 5783: 5772: 5760: 5759: 5743: 5737: 5736: 5724: 5723: 5716: 5709: 5701: 5695: 5694: 5687: 5685:: Polyomavirus 5679: 5669: 5668:External links 5666: 5664: 5663: 5614: 5565: 5516: 5479:PLOS Pathogens 5465: 5416: 5397:(6): 1223–43. 5381: 5338: 5332:978-1598746815 5331: 5313: 5264: 5227:PLOS Pathogens 5213: 5164: 5135:(9): 1378–85. 5115: 5066: 5025: 4989: 4974: 4944: 4906: 4857: 4808: 4787:10.1038/nrc947 4781:(12): 957–64. 4765: 4727: 4689: 4675:10.1086/597126 4648: 4607: 4572: 4523: 4472: 4443:(2): 295–303. 4423: 4384:(11): e49449. 4356: 4307: 4258: 4209: 4180:(10): 1560–5. 4160: 4108: 4059: 4024: 3989: 3960:(10): 1595–9. 3936: 3877: 3848:(9): 4586–90. 3828: 3777: 3740:PLOS Pathogens 3726: 3676: 3650: 3599: 3548: 3504: 3453: 3418: 3391:(3): 532–542. 3374: 3349: 3320:(9): 1627–34. 3300: 3271:(12): 5663–9. 3251: 3228: 3214: 3165: 3114: 3060: 3011: 2982:(9): 3623–34. 2962: 2913: 2854: 2813: 2769: 2730:(8): 3679–84. 2710: 2651: 2608: 2557: 2508: 2493: 2456: 2427:(1): a013250. 2404: 2367:PLOS Pathogens 2353: 2316:PLOS Pathogens 2299: 2258: 2221:PLOS Pathogens 2204: 2177:(6): 895–904. 2161: 2128: 2066: 2012: 1960: 1916: 1879:PLOS Pathogens 1862: 1813: 1745: 1714:(6): 1739–50. 1685: 1659: 1632: 1582: 1580: 1577: 1569:black sea bass 1533: 1530: 1520: 1517: 1487: 1484: 1451:Main article: 1448: 1445: 1407: 1404: 1391: 1390: 1388: 1385: 1382: 1377: 1374: 1371: 1368: 1362: 1361: 1359: 1356: 1353: 1348: 1345: 1340: 1337: 1329: 1328: 1326: 1323: 1320: 1315: 1312: 1307: 1304: 1296: 1295: 1293: 1290: 1287: 1282: 1279: 1274: 1271: 1263: 1262: 1260: 1257: 1254: 1249: 1246: 1241: 1238: 1230: 1229: 1227: 1224: 1221: 1216: 1213: 1208: 1205: 1197: 1196: 1194: 1191: 1188: 1183: 1180: 1175: 1172: 1164: 1163: 1161: 1156: 1153: 1148: 1145: 1140: 1137: 1129: 1128: 1126: 1116: 1113: 1108: 1105: 1100: 1097: 1089: 1088: 1086: 1083: 1080: 1075: 1072: 1067: 1064: 1056: 1055: 1053: 1050: 1047: 1042: 1039: 1034: 1031: 1023: 1022: 1020: 1017: 1014: 1009: 1006: 1001: 998: 990: 989: 987: 982: 979: 974: 971: 966: 963: 955: 954: 952: 947: 944: 939: 936: 931: 928: 920: 919: 916: 913: 910: 904: 901: 898: 897:Proposed genus 895: 881: 878: 861: 858: 853: 852: 845: 838: 831: 824: 813: 812: 805: 798: 791: 784: 777: 761: 760: 755:(type species 749: 744:(type species 738: 733:(type species 711:Papillomavirus 691: 688: 667: 664: 636: 633: 577:retinoblastoma 567: 566:Tumor antigens 564: 562: 561:Viral proteins 559: 455:5HT2A receptor 413:hydrogen bonds 397: 394: 258: 255: 225:whose natural 218:Polyomaviridae 212: 211: 210: 209: 202: 195: 188: 181: 174: 164: 163: 159: 158: 155:Polyomaviridae 151: 147: 146: 139: 135: 134: 127: 123: 122: 115: 111: 110: 103: 99: 98: 91: 84: 83: 78: 74: 73: 60: 59: 48: 47: 39: 38: 36:Polyomaviridae 26: 9: 6: 4: 3: 2: 9703: 9692: 9689: 9687: 9684: 9682: 9679: 9678: 9676: 9659: 9654: 9650: 9646: 9641: 9637: 9633: 9628: 9624: 9620: 9615: 9611: 9607: 9602: 9598: 9594: 9589: 9585: 9581: 9576: 9572: 9567: 9561: 9557: 9552: 9546: 9542: 9541: 9539: 9537: 9533: 9529: 9524: 9484: 9483: 9479: 9478: 9476: 9474: 9473: 9468: 9462: 9461: 9457: 9456: 9454: 9452: 9451: 9450:Blubervirales 9446: 9443: 9441: 9440: 9435: 9432: 9430: 9429: 9424: 9421: 9419: 9418: 9413: 9410: 9408: 9407: 9402: 9398: 9394: 9388: 9384: 9354: 9353: 9349: 9347: 9346: 9345:Pseudoviridae 9342: 9340: 9339: 9335: 9333: 9332: 9331:Belpaoviridae 9328: 9327: 9325: 9323: 9322: 9317: 9314: 9312: 9311: 9306: 9303: 9301: 9300: 9295: 9292: 9290: 9289: 9284: 9281: 9279: 9278: 9273: 9269: 9265: 9259: 9255: 9252: 9250: 9246: 9212: 9211: 9207: 9206: 9204: 9202: 9201: 9196: 9193: 9191: 9190: 9185: 9175: 9174: 9170: 9168: 9167: 9163: 9161: 9160: 9159:Rhabdoviridae 9156: 9154: 9153: 9152:Pneumoviridae 9149: 9147: 9146: 9142: 9140: 9139: 9135: 9133: 9132: 9131:Mymonaviridae 9128: 9126: 9125: 9121: 9119: 9118: 9114: 9112: 9111: 9107: 9105: 9104: 9100: 9099: 9097: 9095: 9094: 9089: 9083: 9082: 9081:Natareviridae 9078: 9076: 9075: 9071: 9069: 9068: 9064: 9062: 9061: 9057: 9055: 9054: 9050: 9049: 9047: 9045: 9044: 9039: 9036: 9034: 9033: 9028: 9018: 9017: 9013: 9012: 9010: 9008: 9007: 9002: 8999: 8997: 8996: 8991: 8981: 8980: 8976: 8974: 8973: 8972:Amnoonviridae 8969: 8968: 8966: 8964: 8963: 8958: 8955: 8953: 8952: 8947: 8937: 8936: 8935:Wupedeviridae 8932: 8930: 8929: 8925: 8923: 8922: 8921:Phenuiviridae 8918: 8916: 8915: 8914:Phasmaviridae 8911: 8909: 8908: 8904: 8902: 8901: 8897: 8895: 8894: 8890: 8888: 8887: 8883: 8881: 8880: 8876: 8874: 8873: 8869: 8867: 8866: 8862: 8860: 8859: 8855: 8854: 8852: 8850: 8849: 8844: 8841: 8839: 8838: 8833: 8823: 8822: 8818: 8817: 8815: 8813: 8812: 8807: 8804: 8802: 8801: 8796: 8793: 8791: 8790: 8785: 8782: 8780: 8779: 8778:Orthornavirae 8774: 8771: 8769: 8768: 8763: 8759: 8755: 8749: 8745: 8723: 8722: 8718: 8716: 8715: 8710: 8707: 8706: 8704: 8700: 8686: 8685: 8681: 8680: 8678: 8676: 8675: 8674:Stellavirales 8670: 8664: 8663: 8659: 8658: 8656: 8654: 8653: 8652:Patatavirales 8648: 8645: 8643: 8642: 8637: 8627: 8626: 8625:Solemoviridae 8622: 8620: 8619: 8615: 8613: 8612: 8608: 8607: 8605: 8603: 8602: 8601:Sobelivirales 8597: 8591: 8590: 8586: 8584: 8583: 8579: 8577: 8576: 8572: 8570: 8569: 8565: 8563: 8562: 8561:Caliciviridae 8558: 8556: 8555: 8551: 8549: 8548: 8544: 8542: 8541: 8537: 8536: 8534: 8532: 8531: 8526: 8520: 8519: 8518:Tobaniviridae 8515: 8513: 8512: 8508: 8506: 8505: 8501: 8499: 8498: 8494: 8492: 8491: 8487: 8485: 8484: 8483:Mononiviridae 8480: 8478: 8477: 8476:Mesoniviridae 8473: 8471: 8470: 8466: 8464: 8463: 8462:Gresnaviridae 8459: 8457: 8456: 8455:Euroniviridae 8452: 8450: 8449: 8448:Coronaviridae 8445: 8443: 8442: 8438: 8436: 8435: 8434:Arteriviridae 8431: 8429: 8428: 8427:Abyssoviridae 8424: 8423: 8421: 8419: 8418: 8413: 8410: 8408: 8407: 8402: 8399: 8397: 8396: 8391: 8377: 8376: 8372: 8371: 8369: 8367: 8366: 8361: 8358: 8356: 8355: 8350: 8340: 8339: 8335: 8334: 8332: 8330: 8329: 8328:Cryppavirales 8324: 8321: 8319: 8318: 8313: 8303: 8302: 8298: 8297: 8295: 8293: 8292: 8287: 8284: 8282: 8281: 8276: 8266: 8265: 8264:Steitzviridae 8261: 8259: 8258: 8254: 8253: 8251: 8249: 8248: 8243: 8237: 8236: 8235:Solspiviridae 8232: 8230: 8229: 8225: 8223: 8222: 8218: 8216: 8215: 8214:Atkinsviridae 8211: 8210: 8208: 8206: 8205: 8200: 8197: 8195: 8194: 8193:Leviviricetes 8189: 8186: 8184: 8183: 8182:Lenarviricota 8178: 8164: 8163: 8162:Tombusviridae 8159: 8157: 8156: 8152: 8150: 8149: 8145: 8144: 8142: 8140: 8139: 8134: 8131: 8129: 8128: 8123: 8113: 8112: 8108: 8106: 8105: 8101: 8100: 8098: 8096: 8095: 8094:Nodamuvirales 8090: 8087: 8085: 8084: 8079: 8069: 8068: 8064: 8063: 8061: 8059: 8058: 8053: 8050: 8048: 8047: 8042: 8032: 8031: 8027: 8025: 8024: 8020: 8018: 8017: 8013: 8011: 8010: 8006: 8004: 8003: 7999: 7998: 7996: 7994: 7993: 7988: 7982: 7981: 7977: 7975: 7974: 7970: 7968: 7967: 7963: 7961: 7960: 7956: 7954: 7953: 7949: 7947: 7946: 7942: 7940: 7939: 7935: 7934: 7932: 7930: 7929: 7924: 7918: 7917: 7916:Matonaviridae 7913: 7911: 7910: 7906: 7904: 7903: 7899: 7897: 7896: 7892: 7891: 7889: 7887: 7886: 7885:Hepelivirales 7881: 7878: 7876: 7875: 7874:Alsuviricetes 7870: 7867: 7865: 7864: 7859: 7856: 7854: 7853: 7852:Orthornavirae 7848: 7845: 7843: 7842: 7837: 7833: 7829: 7823: 7819: 7797: 7796: 7791: 7788: 7786: 7785: 7781: 7779: 7778: 7773: 7770: 7769: 7767: 7763: 7749: 7748: 7744: 7742: 7741: 7737: 7735: 7734: 7730: 7728: 7727: 7723: 7721: 7720: 7719:Amalgaviridae 7716: 7715: 7713: 7711: 7710: 7705: 7702: 7700: 7699: 7694: 7691: 7689: 7688: 7683: 7669: 7668: 7664: 7663: 7661: 7659: 7658: 7653: 7650: 7648: 7647: 7642: 7632: 7631: 7627: 7626: 7624: 7622: 7621: 7616: 7613: 7611: 7610: 7605: 7595: 7594: 7590: 7588: 7587: 7586:Quadriviridae 7583: 7581: 7580: 7576: 7574: 7573: 7572:Chrysoviridae 7569: 7568: 7566: 7564: 7563: 7562:Ghabrivirales 7558: 7555: 7553: 7552: 7547: 7544: 7542: 7541: 7536: 7533: 7531: 7530: 7529:Orthornavirae 7525: 7522: 7520: 7519: 7514: 7510: 7506: 7505:dsRNA viruses 7500: 7496: 7493: 7491: 7487: 7469: 7468: 7464: 7462: 7461: 7457: 7455: 7454: 7453:Anelloviridae 7449: 7446: 7445: 7443: 7439: 7417: 7416: 7412: 7411: 7409: 7407: 7406: 7405:Haloruvirales 7401: 7398: 7396: 7395: 7390: 7387: 7385: 7384: 7379: 7376: 7374: 7373: 7368: 7350: 7349: 7348:Genomoviridae 7345: 7343: 7342: 7341:Geminiviridae 7338: 7337: 7335: 7333: 7332: 7327: 7324: 7322: 7321: 7316: 7306: 7305: 7301: 7300: 7298: 7296: 7295: 7290: 7284: 7283: 7279: 7277: 7276: 7275:Metaxyviridae 7272: 7271: 7269: 7267: 7266: 7261: 7255: 7254: 7250: 7249: 7247: 7245: 7244: 7239: 7233: 7232: 7228: 7227: 7225: 7223: 7222: 7217: 7211: 7210: 7206: 7205: 7203: 7201: 7200: 7195: 7192: 7190: 7189: 7188:Arfiviricetes 7184: 7181: 7179: 7178: 7173: 7159: 7158: 7154: 7153: 7151: 7149: 7148: 7143: 7140: 7138: 7137: 7132: 7122: 7121: 7117: 7116: 7114: 7112: 7111: 7106: 7103: 7101: 7100: 7095: 7092: 7090: 7089: 7088:Cossaviricota 7084: 7081: 7079: 7078: 7073: 7055: 7054: 7050: 7049: 7047: 7045: 7044: 7039: 7036: 7034: 7033: 7028: 7025: 7023: 7022: 7017: 7014: 7012: 7011: 7006: 6988: 6987: 6983: 6981: 6980: 6976: 6974: 6973: 6969: 6968: 6966: 6964: 6963: 6962:Tubulavirales 6958: 6955: 6953: 6952: 6947: 6944: 6942: 6941: 6936: 6933: 6931: 6930: 6925: 6922: 6920: 6919: 6914: 6910: 6906: 6905:ssDNA viruses 6900: 6896: 6878: 6877: 6876:Rhizidiovirus 6873: 6871: 6870: 6865: 6862: 6860: 6859: 6858:Thaspiviridae 6855: 6853: 6852: 6848: 6846: 6845: 6841: 6839: 6838: 6837:Plasmaviridae 6834: 6832: 6831: 6827: 6825: 6824: 6823:Halspiviridae 6820: 6818: 6817: 6813: 6811: 6810: 6806: 6804: 6803: 6799: 6797: 6796: 6792: 6790: 6789: 6785: 6783: 6782: 6777: 6774: 6773: 6771: 6767: 6757: 6756: 6752: 6751: 6749: 6745: 6739: 6738: 6734: 6732: 6731: 6727: 6725: 6724: 6723:Baculoviridae 6720: 6719: 6717: 6715: 6714: 6709: 6706: 6704: 6703: 6698: 6695: 6691: 6669: 6668: 6664: 6662: 6661: 6660:Simuloviridae 6657: 6655: 6654: 6650: 6649: 6647: 6645: 6644: 6639: 6636: 6634: 6633: 6628: 6625: 6623: 6622: 6617: 6614: 6612: 6611: 6610:Helvetiavirae 6606: 6588: 6587: 6583: 6582: 6580: 6578: 6577: 6572: 6566: 6565: 6561: 6560: 6558: 6556: 6555: 6550: 6544: 6543: 6539: 6538: 6536: 6534: 6533: 6532:Kalamavirales 6528: 6522: 6521: 6517: 6516: 6514: 6512: 6511: 6510:Belfryvirales 6506: 6503: 6501: 6500: 6495: 6485: 6484: 6483:Adintoviridae 6480: 6479: 6477: 6475: 6474: 6469: 6466: 6464: 6463: 6458: 6448: 6447: 6446:Lavidaviridae 6443: 6442: 6440: 6438: 6437: 6432: 6429: 6427: 6426: 6421: 6418: 6416: 6415: 6410: 6396: 6395: 6391: 6389: 6388: 6384: 6382: 6381: 6377: 6376: 6374: 6372: 6371: 6366: 6360: 6359: 6355: 6354: 6352: 6350: 6349: 6348:Imitervirales 6344: 6338: 6337: 6333: 6332: 6330: 6328: 6327: 6322: 6319: 6317: 6316: 6315:Megaviricetes 6311: 6301: 6300: 6296: 6295: 6293: 6291: 6290: 6285: 6279: 6278: 6274: 6273: 6271: 6269: 6268: 6263: 6260: 6258: 6257: 6252: 6249: 6247: 6246: 6241: 6238: 6236: 6235: 6230: 6227: 6225: 6224: 6219: 6197: 6196: 6192: 6191: 6189: 6187: 6186: 6181: 6175: 6174: 6170: 6169: 6167: 6165: 6164: 6163:Sepolyvirales 6159: 6156: 6154: 6153: 6148: 6145: 6143: 6142: 6141:Cossaviricota 6137: 6134: 6132: 6131: 6126: 6123: 6121: 6120: 6115: 6093: 6092: 6091:Zobellviridae 6088: 6086: 6085: 6081: 6079: 6078: 6077:Schitoviridae 6074: 6072: 6071: 6067: 6065: 6064: 6060: 6058: 6057: 6053: 6051: 6050: 6046: 6044: 6043: 6039: 6037: 6036: 6035:Guelinviridae 6032: 6030: 6029: 6025: 6023: 6022: 6018: 6016: 6015: 6011: 6009: 6008: 6004: 6002: 6001: 5997: 5996: 5994: 5992: 5991: 5986: 5983: 5981: 5980: 5975: 5972: 5970: 5969: 5964: 5950: 5949: 5945: 5943: 5942: 5941:Herpesviridae 5938: 5936: 5935: 5931: 5930: 5928: 5926: 5925: 5924:Herpesvirales 5920: 5917: 5915: 5914: 5909: 5906: 5904: 5903: 5902:Peploviricota 5898: 5895: 5893: 5892: 5887: 5884: 5882: 5881: 5880:Duplodnaviria 5876: 5854: 5853: 5849: 5848: 5846: 5844: 5843: 5838: 5832: 5831: 5827: 5825: 5824: 5820: 5819: 5817: 5815: 5814: 5809: 5806: 5804: 5803: 5802:Tokiviricetes 5798: 5795: 5793: 5792: 5791:Taleaviricota 5787: 5784: 5782: 5781: 5776: 5773: 5771: 5770: 5765: 5761: 5757: 5756:dsDNA viruses 5751: 5747: 5744: 5742: 5738: 5733: 5729: 5722: 5717: 5715: 5710: 5708: 5703: 5702: 5699: 5693: 5692: 5688: 5686: 5684: 5680: 5678: 5676: 5672: 5671: 5659: 5655: 5650: 5645: 5641: 5637: 5633: 5629: 5625: 5618: 5610: 5606: 5601: 5596: 5592: 5588: 5584: 5580: 5576: 5569: 5561: 5557: 5552: 5547: 5543: 5539: 5535: 5531: 5527: 5520: 5512: 5508: 5503: 5498: 5493: 5488: 5484: 5480: 5476: 5469: 5461: 5457: 5452: 5447: 5443: 5439: 5435: 5431: 5427: 5420: 5412: 5408: 5404: 5400: 5396: 5392: 5385: 5377: 5373: 5369: 5365: 5361: 5357: 5354:(2): 414–21. 5353: 5349: 5342: 5334: 5328: 5325:. Routledge. 5324: 5317: 5309: 5305: 5300: 5295: 5291: 5287: 5283: 5279: 5275: 5268: 5260: 5256: 5251: 5246: 5241: 5236: 5232: 5228: 5224: 5217: 5209: 5205: 5200: 5195: 5191: 5187: 5184:(6): 1250–6. 5183: 5179: 5175: 5168: 5160: 5156: 5151: 5146: 5142: 5138: 5134: 5130: 5126: 5119: 5111: 5107: 5103: 5099: 5094: 5089: 5085: 5081: 5077: 5070: 5062: 5058: 5053: 5048: 5045:(5): 1080–9. 5044: 5040: 5036: 5029: 5021: 5017: 5013: 5009: 5005: 5001: 4993: 4985: 4981: 4977: 4971: 4967: 4963: 4959: 4955: 4948: 4940: 4936: 4932: 4928: 4924: 4920: 4913: 4911: 4902: 4898: 4894: 4890: 4885: 4880: 4877:(2): 215–23. 4876: 4872: 4868: 4861: 4853: 4849: 4844: 4839: 4835: 4831: 4828:(9): 1295–7. 4827: 4823: 4819: 4812: 4804: 4800: 4796: 4792: 4788: 4784: 4780: 4776: 4769: 4761: 4757: 4753: 4749: 4745: 4741: 4734: 4732: 4723: 4719: 4715: 4711: 4707: 4703: 4696: 4694: 4685: 4681: 4676: 4671: 4668:(6): 837–46. 4667: 4663: 4659: 4652: 4644: 4640: 4635: 4630: 4627:(6): 354–77. 4626: 4622: 4618: 4611: 4603: 4599: 4595: 4591: 4587: 4583: 4576: 4568: 4564: 4559: 4554: 4550: 4546: 4542: 4538: 4534: 4527: 4519: 4515: 4510: 4505: 4500: 4495: 4491: 4487: 4483: 4476: 4468: 4464: 4459: 4454: 4450: 4446: 4442: 4438: 4434: 4427: 4419: 4415: 4410: 4405: 4400: 4395: 4391: 4387: 4383: 4379: 4375: 4371: 4367: 4360: 4352: 4348: 4343: 4338: 4334: 4330: 4327:(19): 10887. 4326: 4322: 4318: 4311: 4303: 4299: 4294: 4289: 4285: 4281: 4277: 4273: 4269: 4262: 4254: 4250: 4245: 4240: 4236: 4232: 4228: 4224: 4220: 4213: 4205: 4201: 4196: 4191: 4187: 4183: 4179: 4175: 4171: 4164: 4156: 4152: 4147: 4142: 4138: 4134: 4130: 4126: 4122: 4115: 4113: 4104: 4100: 4095: 4090: 4086: 4082: 4079:(8): 4130–6. 4078: 4074: 4070: 4063: 4055: 4051: 4047: 4043: 4039: 4035: 4028: 4020: 4016: 4012: 4008: 4004: 4000: 3993: 3985: 3981: 3976: 3971: 3967: 3963: 3959: 3955: 3951: 3947: 3940: 3932: 3928: 3923: 3918: 3913: 3908: 3904: 3900: 3897:(3): e58021. 3896: 3892: 3888: 3881: 3873: 3869: 3864: 3859: 3855: 3851: 3847: 3843: 3839: 3832: 3824: 3820: 3816: 3812: 3807: 3802: 3799:(8): 770–82. 3798: 3794: 3793: 3788: 3781: 3773: 3769: 3764: 3759: 3754: 3749: 3745: 3741: 3737: 3730: 3722: 3718: 3713: 3708: 3704: 3700: 3697:(6): 1243–9. 3696: 3692: 3688: 3680: 3665: 3661: 3654: 3646: 3642: 3637: 3632: 3627: 3622: 3618: 3614: 3610: 3603: 3595: 3591: 3586: 3581: 3576: 3571: 3567: 3563: 3559: 3552: 3544: 3540: 3536: 3532: 3528: 3524: 3520: 3516: 3508: 3500: 3496: 3491: 3486: 3481: 3476: 3472: 3468: 3464: 3457: 3449: 3445: 3441: 3437: 3433: 3429: 3422: 3414: 3410: 3406: 3402: 3398: 3394: 3390: 3386: 3378: 3362: 3356: 3354: 3345: 3341: 3336: 3331: 3327: 3323: 3319: 3315: 3311: 3304: 3296: 3292: 3287: 3282: 3278: 3274: 3270: 3266: 3262: 3255: 3247: 3243: 3239: 3232: 3224: 3218: 3210: 3206: 3201: 3196: 3192: 3188: 3184: 3180: 3176: 3169: 3161: 3157: 3152: 3147: 3142: 3137: 3133: 3129: 3125: 3118: 3110: 3106: 3101: 3096: 3092: 3088: 3085:(6): 509–15. 3084: 3080: 3076: 3069: 3067: 3065: 3056: 3052: 3047: 3042: 3038: 3034: 3030: 3026: 3022: 3015: 3007: 3003: 2998: 2993: 2989: 2985: 2981: 2977: 2973: 2966: 2958: 2954: 2949: 2944: 2940: 2936: 2933:(2): 125–35. 2932: 2928: 2924: 2917: 2909: 2905: 2900: 2895: 2890: 2885: 2881: 2877: 2873: 2869: 2865: 2858: 2850: 2846: 2841: 2836: 2833:(5): 887–97. 2832: 2828: 2824: 2817: 2809: 2805: 2801: 2797: 2793: 2789: 2786:(1): 167–76. 2785: 2781: 2773: 2765: 2761: 2756: 2751: 2746: 2741: 2737: 2733: 2729: 2725: 2721: 2714: 2706: 2702: 2697: 2692: 2687: 2682: 2678: 2674: 2670: 2666: 2662: 2655: 2647: 2643: 2639: 2635: 2631: 2627: 2623: 2619: 2612: 2604: 2600: 2595: 2594:11392/2378829 2590: 2585: 2580: 2576: 2572: 2568: 2561: 2553: 2549: 2544: 2539: 2535: 2531: 2527: 2523: 2519: 2512: 2504: 2500: 2496: 2494:9780123747716 2490: 2486: 2482: 2478: 2474: 2467: 2465: 2463: 2461: 2452: 2448: 2443: 2438: 2434: 2430: 2426: 2422: 2418: 2411: 2409: 2400: 2396: 2391: 2386: 2381: 2376: 2372: 2368: 2364: 2357: 2349: 2345: 2340: 2335: 2330: 2325: 2321: 2317: 2313: 2306: 2304: 2295: 2291: 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1576: 1574: 1570: 1565: 1562: 1558: 1554: 1553:Sarah Stewart 1550: 1549:parotid gland 1546: 1542: 1538: 1529: 1527: 1516: 1512: 1508: 1506: 1500: 1498: 1492: 1483: 1481: 1477: 1476:mesotheliomas 1473: 1469: 1465: 1464:polio vaccine 1460: 1454: 1444: 1442: 1438: 1434: 1430: 1426: 1422: 1418: 1414: 1403: 1400: 1397: 1389: 1386: 1383: 1381: 1378: 1375: 1372: 1369: 1367: 1364: 1363: 1360: 1357: 1354: 1352: 1349: 1346: 1344: 1341: 1338: 1335: 1331: 1330: 1327: 1324: 1321: 1319: 1316: 1313: 1311: 1308: 1305: 1302: 1298: 1297: 1294: 1291: 1288: 1286: 1283: 1280: 1278: 1275: 1272: 1269: 1265: 1264: 1261: 1258: 1255: 1253: 1250: 1247: 1245: 1242: 1239: 1236: 1232: 1231: 1228: 1225: 1222: 1220: 1217: 1214: 1212: 1209: 1206: 1203: 1199: 1198: 1195: 1192: 1189: 1187: 1184: 1181: 1179: 1176: 1173: 1170: 1166: 1165: 1162: 1160: 1157: 1154: 1152: 1149: 1146: 1144: 1141: 1138: 1135: 1131: 1130: 1127: 1125: 1121: 1117: 1114: 1112: 1109: 1106: 1104: 1101: 1098: 1095: 1091: 1090: 1087: 1084: 1081: 1079: 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468: 464: 460: 456: 452: 448: 444: 440: 436: 432: 423: 419: 414: 410: 406: 402: 393: 391: 387: 383: 379: 375: 371: 367: 363: 362:translational 359: 355: 351: 347: 343: 335: 330: 326: 324: 320: 316: 312: 308: 304: 300: 296: 292: 289: 288:non-enveloped 280: 276: 271: 268: 263: 254: 252: 248: 244: 240: 236: 232: 228: 224: 220: 219: 208: 207: 203: 201: 200: 196: 194: 193: 189: 187: 186: 182: 180: 179: 175: 173: 172: 168: 167: 165: 160: 157: 156: 152: 149: 148: 145: 144: 143:Sepolyvirales 140: 137: 136: 133: 132: 128: 125: 124: 121: 120: 119:Cossaviricota 116: 113: 112: 109: 108: 104: 101: 100: 97: 96: 92: 89: 86: 85: 82: 79: 76: 75: 70: 65: 61: 57: 53: 49: 45: 40: 37: 33: 30: 19: 9535: 9480: 9472:Ortervirales 9470: 9458: 9448: 9437: 9426: 9417:Pararnavirae 9415: 9404: 9352:Retroviridae 9350: 9343: 9336: 9329: 9321:Ortervirales 9319: 9308: 9297: 9288:Pararnavirae 9286: 9275: 9208: 9198: 9187: 9173:Xinmoviridae 9171: 9164: 9157: 9150: 9143: 9138:Nyamiviridae 9136: 9129: 9124:Lispiviridae 9122: 9115: 9110:Bornaviridae 9108: 9101: 9091: 9079: 9074:Myriaviridae 9072: 9065: 9058: 9053:Aliusviridae 9051: 9041: 9030: 9014: 9004: 8993: 8977: 8970: 8960: 8949: 8933: 8928:Tospoviridae 8926: 8919: 8912: 8905: 8900:Nairoviridae 8898: 8891: 8884: 8879:Hantaviridae 8877: 8870: 8865:Arenaviridae 8863: 8858:Cruliviridae 8856: 8848:Bunyavirales 8846: 8835: 8819: 8809: 8798: 8787: 8776: 8765: 8719: 8712: 8708: 8684:Astroviridae 8682: 8672: 8660: 8650: 8639: 8623: 8618:Barnaviridae 8616: 8609: 8599: 8587: 8580: 8573: 8566: 8559: 8552: 8547:Marnaviridae 8545: 8538: 8528: 8516: 8509: 8504:Olifoviridae 8502: 8495: 8488: 8481: 8474: 8467: 8460: 8453: 8446: 8439: 8432: 8425: 8415: 8404: 8395:Pisuviricota 8393: 8373: 8365:Ourlivirales 8363: 8354:Miaviricetes 8352: 8336: 8326: 8315: 8301:Narnaviridae 8299: 8289: 8278: 8262: 8257:Blumeviridae 8255: 8247:Timlovirales 8245: 8233: 8228:Fiersviridae 8226: 8219: 8212: 8204:Norzivirales 8202: 8191: 8180: 8160: 8155:Luteoviridae 8153: 8146: 8136: 8125: 8109: 8102: 8092: 8081: 8067:Flaviviridae 8065: 8055: 8044: 8028: 8021: 8014: 8007: 8000: 7990: 7980:Virgaviridae 7978: 7971: 7964: 7957: 7950: 7943: 7938:Bromoviridae 7936: 7926: 7914: 7907: 7900: 7893: 7883: 7872: 7861: 7850: 7839: 7793: 7789: 7782: 7777:Birnaviridae 7775: 7771: 7745: 7738: 7731: 7724: 7717: 7709:Durnavirales 7707: 7696: 7687:Pisuviricota 7685: 7667:Cystoviridae 7665: 7657:Mindivirales 7655: 7644: 7628: 7618: 7607: 7591: 7584: 7577: 7570: 7560: 7549: 7538: 7527: 7516: 7467:Spiraviridae 7465: 7458: 7451: 7447: 7413: 7403: 7392: 7383:Saleviricota 7381: 7370: 7346: 7339: 7329: 7318: 7302: 7294:Recrevirales 7292: 7280: 7273: 7265:Mulpavirales 7263: 7253:Smacoviridae 7251: 7243:Cremevirales 7241: 7231:Circoviridae 7229: 7221:Cirlivirales 7219: 7207: 7199:Baphyvirales 7197: 7186: 7175: 7157:Parvoviridae 7155: 7147:Piccovirales 7145: 7134: 7120:Bidnaviridae 7118: 7108: 7099:Mouviricetes 7097: 7086: 7077:Shotokuvirae 7075: 7053:Microviridae 7051: 7043:Petitvirales 7041: 7030: 7021:Phixviricota 7019: 7008: 6984: 6977: 6970: 6960: 6949: 6938: 6927: 6918:Monodnaviria 6916: 6874: 6869:Dinodnavirus 6867: 6863: 6856: 6849: 6842: 6835: 6830:Ovaliviridae 6828: 6821: 6816:Guttaviridae 6814: 6807: 6800: 6795:Clavaviridae 6793: 6786: 6779: 6775: 6753: 6735: 6728: 6721: 6711: 6700: 6665: 6658: 6651: 6641: 6630: 6619: 6608: 6584: 6574: 6564:Adenoviridae 6562: 6552: 6542:Tectiviridae 6540: 6530: 6520:Turriviridae 6518: 6508: 6497: 6481: 6471: 6460: 6444: 6434: 6423: 6412: 6392: 6387:Iridoviridae 6385: 6378: 6368: 6356: 6346: 6334: 6324: 6313: 6297: 6289:Chitovirales 6287: 6277:Asfarviridae 6275: 6265: 6254: 6243: 6234:Bamfordvirae 6232: 6223:Varidnaviria 6221: 6193: 6183: 6172: 6171: 6161: 6150: 6139: 6130:Shotokuvirae 6128: 6119:Monodnaviria 6117: 6089: 6084:Siphoviridae 6082: 6075: 6068: 6061: 6054: 6047: 6040: 6033: 6026: 6019: 6014:Chaseviridae 6012: 6005: 5998: 5990:Caudovirales 5988: 5977: 5966: 5946: 5939: 5932: 5922: 5911: 5900: 5889: 5878: 5850: 5842:Primavirales 5840: 5828: 5821: 5811: 5800: 5789: 5778: 5767: 5690: 5682: 5674: 5631: 5627: 5617: 5582: 5578: 5568: 5533: 5529: 5519: 5482: 5478: 5468: 5433: 5429: 5419: 5394: 5390: 5384: 5351: 5347: 5341: 5322: 5316: 5281: 5277: 5267: 5230: 5226: 5216: 5181: 5177: 5167: 5132: 5128: 5118: 5086:(4): 485–8. 5083: 5079: 5069: 5042: 5038: 5028: 5006:(1): 23–36. 5003: 4999: 4992: 4957: 4947: 4922: 4918: 4874: 4870: 4860: 4825: 4821: 4811: 4778: 4774: 4768: 4743: 4739: 4705: 4701: 4665: 4661: 4651: 4624: 4620: 4610: 4588:(2): 63–72. 4585: 4581: 4575: 4540: 4536: 4526: 4489: 4485: 4475: 4440: 4436: 4426: 4381: 4377: 4366:Greninger AL 4359: 4324: 4320: 4310: 4275: 4271: 4261: 4226: 4222: 4212: 4177: 4173: 4163: 4128: 4124: 4076: 4072: 4062: 4037: 4033: 4027: 4002: 3998: 3992: 3957: 3953: 3939: 3894: 3890: 3880: 3845: 3841: 3831: 3796: 3790: 3780: 3743: 3739: 3729: 3694: 3690: 3679: 3667:. Retrieved 3663: 3653: 3616: 3612: 3602: 3565: 3561: 3551: 3518: 3514: 3507: 3470: 3466: 3456: 3431: 3427: 3421: 3388: 3384: 3377: 3365:. Retrieved 3317: 3313: 3303: 3268: 3264: 3254: 3245: 3241: 3231: 3217: 3182: 3178: 3168: 3131: 3127: 3117: 3082: 3078: 3028: 3024: 3014: 2979: 2975: 2965: 2930: 2926: 2916: 2871: 2867: 2857: 2830: 2826: 2816: 2783: 2779: 2772: 2727: 2723: 2713: 2668: 2664: 2654: 2624:(1): 69–85. 2621: 2617: 2611: 2574: 2570: 2560: 2525: 2521: 2511: 2476: 2472: 2424: 2420: 2370: 2366: 2356: 2319: 2315: 2293: 2289: 2224: 2220: 2174: 2170: 2164: 2152:. Retrieved 2148:"Viral Zone" 2088: 2084: 2032: 2028: 1983:(2): 310–8. 1980: 1976: 1936: 1932: 1882: 1878: 1830: 1826: 1816: 1781: 1777: 1711: 1707: 1676:. Retrieved 1672: 1662: 1600: 1596: 1586: 1566: 1557:Bernice Eddy 1541:Ludwik Gross 1535: 1522: 1513: 1509: 1505:renal biopsy 1501: 1493: 1489: 1468:brain tumors 1456: 1409: 1401: 1395: 1394: 1365: 1333: 1300: 1267: 1234: 1201: 1168: 1133: 1093: 1060: 1027: 994: 959: 924: 903:Abbreviation 883: 875: 863: 854: 847: 840: 833: 826: 819: 814: 807: 800: 793: 786: 779: 772: 765: 762: 752: 741: 730: 715:Polyomavirus 714: 710: 706: 705:. (The name 700: 693: 669: 656:viral capsid 638: 607: 581: 569: 483: 443:gangliosides 437:residues of 428: 352:as a single 339: 303:viral capsid 285: 217: 216: 215: 204: 197: 190: 183: 176: 169: 154: 153: 142: 141: 130: 118: 107:Shotokuvirae 106: 95:Monodnaviria 94: 87: 77:(unranked): 56:polyomavirus 55: 35: 29: 18:Polyomavirus 9560:Wikispecies 9338:Metaviridae 9117:Filoviridae 9103:Artoviridae 9016:Aspiviridae 8893:Mypoviridae 8872:Fimoviridae 8662:Potyviridae 8575:Secoviridae 8568:Iflaviridae 8511:Roniviridae 8417:Nidovirales 8338:Mitoviridae 8221:Duinviridae 8138:Tolivirales 8104:Nodaviridae 8030:Tymoviridae 7992:Tymovirales 7973:Togaviridae 7966:Mayoviridae 7959:Kitaviridae 7909:Hepeviridae 7902:Benyviridae 7733:Hypoviridae 7593:Totiviridae 7282:Nanoviridae 7110:Polivirales 7010:Sangervirae 6755:Nimaviridae 6737:Nudiviridae 6713:Lefavirales 6576:Vinavirales 6554:Rowavirales 6380:Ascoviridae 6358:Mimiviridae 6326:Algavirales 6267:Asfuvirales 6056:Podoviridae 5968:Uroviricota 5830:Rudiviridae 5780:Zilligvirae 5675:ICTV Report 4370:Parsonnet J 4223:JCI Insight 1833:(1): 61–9. 1731:10037/13151 1472:bone tumors 1439:(MCV) with 1421:nephropathy 1387:None known 1380:NC_034253.1 1120:nephropathy 918:References 672:agnoprotein 666:Agnoprotein 653:icosahedral 612:is used in 547:agnoprotein 471:endocytosed 441:, commonly 435:sialic acid 378:agnoprotein 311:icosahedral 235:nephropathy 9675:Categories 9210:Yueviridae 9166:Sunviridae 9060:Chuviridae 8821:Qinviridae 8702:Unassigned 7765:Unassigned 7630:Reoviridae 7620:Reovirales 7441:Unassigned 7372:Trapavirae 6972:Inoviridae 6769:Unassigned 6747:Unassigned 6693:Unassigned 6299:Poxviridae 6049:Myoviridae 4746:(5): 687. 3669:18 January 3473:(1): 207. 2296:: 121–131. 2227:(5): e64. 1933:Nephrology 1667:taxonomy. 1579:References 1358:None known 1325:None known 1226:None known 1193:None known 1085:None known 1052:None known 1019:None known 900:Virus name 510:cell cycle 382:non-coding 323:VP2 or VP3 315:capsomeres 307:nanometers 299:base pairs 54:showing a 52:Micrograph 9551:Q18670504 9406:Riboviria 9277:Riboviria 8811:Muvirales 8767:Riboviria 7841:Riboviria 7518:Riboviria 6929:Loebvirae 5769:Adnaviria 5728:Baltimore 5683:Viralzone 4492:: 45–54. 3619:: 45–54. 3568:(1): 35. 3434:: 49–55. 1561:morphemes 1545:leukemias 1486:Diagnosis 1351:NC_020106 1318:NC_018102 1285:NC_014407 1252:NC_014406 1219:NC_009539 1186:NC_009238 1151:NC_001699 1111:NC_001538 1078:NC_024118 1045:NC_020890 1012:NC_015150 977:NC_014361 942:NC_010277 713:, Po for 649:pentamers 618:MMTV-PyMT 603:E3 ligase 497:(ST) and 481:enzymes. 431:host cell 386:promoters 102:Kingdom: 9545:Wikidata 8709:Families 7772:Families 7448:Families 6776:Families 5658:27440877 5609:25635011 5560:11381103 5511:21829355 5460:13819251 5411:13549981 5376:34223353 5368:13064287 5308:19776382 5259:19750217 5208:19499548 5159:19609205 5110:30574884 5102:12352906 5061:10232695 5020:10644084 4984:16626028 4939:16311117 4901:20679358 4893:17131333 4852:11720463 4795:12459734 4760:14566815 4722:16963733 4684:19434930 4643:22461085 4602:23357733 4582:Virology 4567:30328951 4518:28342387 4486:Virology 4467:23276405 4437:Virology 4418:23166671 4378:PLOS ONE 4351:22966183 4302:22740408 4253:27034991 4204:25231015 4155:28040372 4103:17287263 3984:24795478 3946:Pipas JM 3931:23516426 3891:PLOS ONE 3872:21307194 3823:13734654 3815:23593936 3772:20686659 3721:19499546 3645:28342387 3613:Virology 3594:30885224 3543:49351836 3535:29931397 3499:29078783 3448:28284622 3413:46740584 3405:28192039 3344:21562881 3295:16731904 3209:26831433 3160:21609431 3109:20542254 3006:21841310 2957:23954152 2705:25291363 2665:PLOS ONE 2646:20990837 2638:15982744 2603:28174236 2552:21835797 2503:20399955 2479:: 1–51. 2451:23284050 2399:21829355 2348:26474293 2253:17480120 2199:25800023 2150:. 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Index

Polyomavirus

Micrograph
Virus classification
Edit this classification
Virus
Monodnaviria
Shotokuvirae
Cossaviricota
Papovaviricetes
Sepolyvirales
Alphapolyomavirus
Betapolyomavirus
Deltapolyomavirus
Epsilonpolyomavirus
Gammapolyomavirus
Zetapolyomavirus
viruses
hosts
Simian Virus 40
nephropathy
renal transplant
progressive multifocal leukoencephalopathy
Merkel cell virus
Merkel cell cancer

murine polyomavirus
VP1
PDB
1SIE

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