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Concentration-response curves illustrating the concept of potency. For a response of 0.25a.u., Drug B is more potent, as it generates this response at a lower concentration. For a response of 0.75a.u., Drug A is more potent. a.u. refers to "arbitrary
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MILES AA, PERRY EL. Biological potency and its relation to therapeutic efficacy. Bull World Health Organ. 1953;9(1):1-14. PMID: 13082386; PMCID: PMC2542104.
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290:(IUPHAR) has stated that "potency is an imprecise term that should always be further defined", and lists of types of potency as follows:
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It is the minimum dose or concentration of a drug that produces a biological response in 50% of a population being studied.
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expressed in terms of the dose required to produce a pharmacological effect of given intensity. A highly potent drug (e.g.,
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which induces a biological response halfway between the baseline and maximum after a specified exposure time.
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It is a measure of the potency of a substance in inhibiting a specific biological or biochemical function.
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In other words, it can be defined as the concentration required to obtain a 50% effect.
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https://www.addictioncenter.com/news/2019/08/15-most-dangerous-drugs/
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https://nida.nih.gov/research-topics/commonly-used-drugs-charts#top
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Neubig RR, Spedding M, Kenakin T, Christopoulos A (December 2003).
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It is the minimum dose at which toxicity occurs in 50% of cases.
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534:{\displaystyle {\ce {IC_{50}}}}
477:{\displaystyle {\ce {EC_{50}}}}
434:{\displaystyle {\ce {TD_{50}}}}
379:{\displaystyle {\ce {LD_{50}}}}
336:{\displaystyle {\ce {ED_{50}}}}
49:or discuss these issues on the
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1163:Distribution
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665:. Retrieved
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43:Please help
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1515:Bactericide
1191:Compartment
1002:Patch clamp
978:Schild plot
398:lethal dose
302:Definition
264:haloperidol
260:ziprasidone
240:risperidone
99:introducing
1395:Physiology
1327:Toxicology
1219:psychology
1168:Metabolism
1158:Absorption
1152:Liberation
994:Organ bath
922:Functional
801:Antagonist
794:Inhibitory
749:Excitatory
667:2013-11-13
562:References
394:toxic unit
392:, it is a
268:furosemide
256:alprazolam
248:bumetanide
244:benperidol
236:clonazepam
165:March 2016
107:March 2016
82:references
46:improve it
1177:Clearance
1173:Excretion
992:Methods (
274:nor more
146:citations
52:talk page
1534:Category
1295:genetics
1267:Pharmacy
1254:Medicine
1064:Affinity
1023:Efficacy
961:Analysis
943:Toxicity
613:14657418
550:See also
496:toxicant
492:antibody
252:morphine
232:fentanyl
1205:Related
1148:(L)ADME
1102:Initial
1086:Metrics
1033:Potency
1016:Metrics
918:Binding
888:Binding
756:Agonist
621:1729572
299:Symbol
220:potency
210:units".
95:improve
1207:fields
683:
619:
611:
390:toxins
84:, but
1404:Other
1141:LADME
617:S2CID
1293:and
1217:and
1053:TD50
1049:LD50
1045:ED50
1041:IC50
1037:EC50
839:Drug
681:ISBN
609:PMID
488:drug
286:The
1150:: (
601:doi
494:or
222:or
214:In
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579:^
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519:IC
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462:EC
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364:LD
325:50
321:ED
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