1428:
1414:
12785:
5701:
3501:
1072:
608:
331:
2491:(IL-12) and tumor necrosis factor α (TNF-α). The innate immune system generates inflammation and antiviral responses, which cause the release pattern recognition receptors (PRRs). These receptors help in labeling which pathogens are viruses, fungi, or bacteria. Moreover, the importance of siRNA and the innate immune system is to include more PRRs to help recognize different RNA structures. This makes it more likely for the siRNA to cause an immunostimulant response in the event of the pathogen.
2857:
916:
1537:(HAO1) mRNA for breakdown. Lowering HAO1 enzyme levels reduces the oxidation of glycolate to glyoxylate (which is a substrate for oxalate). Lumasiran is administered subcutaneously by a healthcare professional with dosing based on body weight. Data from randomized controlled clinical trials indicate that the most common adverse reaction that was reported was injection site reactions. These reactions were mild and were present in 38 percent of patients treated with lumasiran.
1134:. This phenomenon has since been recognized as a feature of the plant immune system which allows the entire plant to respond to a virus after an initial localized encounter. In response, many plant viruses have evolved elaborate mechanisms to suppress the RNAi response. These include viral proteins that bind short double-stranded RNA fragments with single-stranded overhang ends, such as those produced by Dicer. Some plant genomes also express endogenous
22:
2931:
viral RNA sequences would show similar levels of protection. Researchers believed that viral RNA produced by transgenes could also inhibit viral replication. The reverse experiment, in which short sequences of plant genes were introduced into viruses, showed that the targeted gene was suppressed in an infected plant. This phenomenon was labeled "virus-induced gene silencing" (VIGS), and the set of such phenomena were collectively called
3059:
771:
187:
112:), are central to components to the RNAi pathway. Once mRNA is degraded, post-transcriptional silencing occurs as protein translation is prevented. Transcription can be inhibited via the pre-transcriptional silencing mechanism of RNAi, through which an enzyme complex catalyzes DNA methylation at genomic positions complementary to complexed siRNA or miRNA. RNAi has an important role in defending cells against parasitic
580:
2910:
decreased or became suppressed in a context-specific manner. This would later be explained as the result of the transgene being inserted adjacent to promoters in the opposite direction in various positions throughout the genomes of some transformants, thus leading to expression of antisense transcripts and gene silencing when these promoters are active. Another early observation of RNAi came from a study of the
3073:
166:, because synthetic dsRNA introduced into cells can selectively and robustly induce suppression of specific genes of interest. RNAi may be used for large-scale screens that systematically shut down each gene (and the subsequent proteins it codes for) in the cell, which can help to identify the components necessary for a particular cellular process or an event such as
2843:
large data sets is a fundamental challenge, requiring suitable statistics/bioinformatics methods. The basic process of cell-based RNAi screening includes the choice of an RNAi library, robust and stable cell types, transfection with RNAi agents, treatment/incubation, signal detection, analysis and identification of important genes or therapeutical targets.
155:(RISC). The RISC assembly then binds and degrades the target mRNA. Specifically, this is accomplished when the guide strand pairs with a complementary sequence in a mRNA molecule and induces cleavage by Ago2, a catalytic component of the RISC. In some organisms, this process spreads systemically, despite the initially limited molar concentrations of siRNA.
2596:, employing multiple approaches, including genetic engineering and topical application. Cells in the midgut of some insects take up the dsRNA molecules in the process referred to as environmental RNAi. In some insects the effect is systemic as the signal spreads throughout the insect's body (referred to as systemic RNAi).
280:, a miRNA-loaded RISC complex scans cytoplasmic mRNAs for potential complementarity. Instead of destructive cleavage (by Ago2), miRNAs rather target the 3′ untranslated region (UTR) regions of mRNAs where they typically bind with imperfect complementarity, thus blocking the access of ribosomes for translation.
904:(ADAR). It was originally proposed in 2000 that the RNAi and A→I RNA editing pathways might compete for a common dsRNA substrate. Some pre-miRNAs do undergo A→I RNA editing and this mechanism may regulate the processing and expression of mature miRNAs. Furthermore, at least one mammalian ADAR can sequester
2312:. These two vaccines use lipid nanoparticles to deliver antigen mRNA. Encapsulating the mRNA molecule in lipid nanoparticles was a critical breakthrough for producing viable mRNA vaccines, solving a number of key technical barriers in delivering the mRNA molecule into the host cell as distributed through
2909:
into petunia plants of normally pink or violet flower color. The overexpressed gene was expected to result in darker flowers, but instead caused some flowers to have less visible purple pigment, sometimes in variegated patterns, indicating that the activity of chalcone synthase had been substantially
2490:
siRNA is controlled by the innate immune system, which can be divided into the acute inflammatory responses and antiviral responses. The inflammatory response is created with signals from small signaling molecules, or cytokines. These include interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-12
1321:
enzyme starts to process siRNA. The end result of the process leads to degradation of mRNA and destroys any instructions needed to build certain proteins. Using this method, researchers are able to decrease (but not completely eliminate) the expression of a targeted gene. Studying the effects of this
2486:
The challenge between old pathogens and new has helped create a system of guarded cells and particles that are called safe framework. This framework has given humans an army of systems that search out and destroy invader particles, such as pathogens, microscopic organisms, parasites, and infections.
2441:
Compared with chemotherapy or other anti-cancer drugs, there are a lot of advantages of siRNA drug. SiRNA acts on the post-transcriptional stage of gene expression, so it does not modify or change DNA in a deleterious effect. SiRNA can also be used to produce a specific response in a certain type of
2229:
Currently, both miRNA and SiRNA are currently chemically synthesized and so, are legally categorized inside EU and in USA as "simple" medicinal products. But as bioengineered siRNA (BERAs) are in development, these would be classified as biological medicinal products, at least in EU. The development
1459:
While all of the current regulatory body approved RNAi therapeutics focus on diseases that originate in the liver, additional medications under investigation target a host of disease areas including cardiovascular diseases, bleeding disorders, alcohol use disorders, cystic fibrosis, gout, carcinoma,
1049:
Gene expression in prokaryotes is influenced by an RNA-based system similar in some respects to RNAi. Here, RNA-encoding genes control mRNA abundance or translation by producing a complementary RNA that anneals to an mRNA. However these regulatory RNAs are not generally considered to be analogous to
750:
to its mRNA target. Analysis of the inhibitory effect of mismatches in either the 5’ or 3’ end of the guide strand has demonstrated that the 5’ end of the guide strand is likely responsible for matching and binding the target mRNA, while the 3’ end is responsible for physically arranging target mRNA
2930:
working on improving plant resistance to viral diseases observed a similar unexpected phenomenon. While it was known that plants expressing virus-specific proteins showed enhanced tolerance or resistance to viral infection, it was not expected that plants carrying only short, non-coding regions of
2842:
discovery platforms. One major advantage of genome-scale RNAi screening is its ability to simultaneously interrogate thousands of genes. With the ability to generate a large amount of data per experiment, genome-scale RNAi screening has led to an explosion of data generation rates. Exploiting such
2425:
can effectively kill cancer cells, lack of specificity for discriminating normal cells and cancer cells in these treatments usually cause severe side effects. Numerous studies have demonstrated that RNAi can provide a more specific approach to inhibit tumor growth by targeting cancer-related genes
875:
that target subsequent transcripts. Heterochromatin maintenance has been suggested to function as a self-reinforcing feedback loop, as new siRNAs are formed from the occasional nascent transcripts by RdRP for incorporation into local RITS complexes. The relevance of observations from fission yeast
2445:
RNAi drugs treat cancer by silencing certain cancer promoting genes. This is done by complementing the cancer genes with the RNAi, such as keeping the mRNA sequences in accordance with the RNAi drug. Ideally, RNAi is should be injected and/or chemically modified so the RNAi can reach cancer cells
1316:
is a method used to reduce the expression of an organism’s specific genes. This is accomplished by using the naturally occurring process of RNAi. This gene knockdown technique uses a double-stranded siRNA molecule that is synthesized with a sequence complementary to the gene of interest. The RNAi
1164:
The role of RNAi in mammalian innate immunity is poorly understood, and relatively little data is available. However, the existence of viruses that encode genes able to suppress the RNAi response in mammalian cells may be evidence in favour of an RNAi-dependent mammalian immune response, although
964:
of promoters targeted by RNAi; the new methylation pattern is copied in each new generation of the cell. A broad general distinction between plants and animals lies in the targeting of endogenously produced miRNAs; in plants, miRNAs are usually perfectly or nearly perfectly complementary to their
2482:
The human immune system is divided into two separate branches: the innate immune system and the adaptive immune system. The innate immune system is the first defense against infection and responds to pathogens in a generic fashion. On the other hand, the adaptive immune system, a system that was
484:
as well as for regulatory proteins. By binding to specific sites within the 3′-UTR, miRNAs can decrease gene expression of various mRNAs by either inhibiting translation or directly causing degradation of the transcript. The 3′-UTR also may have silencer regions that bind repressor proteins that
2261:
Lipid nanoparticles (LNPs) are based on liposome-like structures that are typically made of an aqueous center surrounded by a lipid shell. A subset of liposomal structures used for delivery drugs to tissues rest in large unilamellar vesicles (LUVs) which may be 100 nm in size. LNP delivery
2243:
is susceptible to several obstacles that reduce its therapeutic efficacy. Additionally, once siRNA has entered the bloodstream, naked RNA can be degraded by serum nucleases and can stimulate the innate immune system. Due to its size and highly polyanionic (containing negative charges at several
1435:
The technique of knocking down genes using RNAi therapeutics has demonstrated success in randomized controlled clinical studies. These medications are a growing class of siRNA-based drugs that decrease the expression of proteins encoded by certain genes. To date, five RNAi medications have been
259:
are then separated into single strands and integrated into an active RISC, by RISC-Loading
Complex (RLC). RLC includes Dicer-2 and R2D2, and is crucial to unite Ago2 and RISC. TATA-binding protein-associated factor 11 (TAF11) assembles the RLC by facilitating Dcr-2-R2D2 tetramerization, which
264:
duplexes, whereas Dicer-2 the other less stable extremity. Loading is asymmetric: the MID domain of Ago2 recognizes the thermodynamically stable end of the siRNA. Therefore, the "passenger" (sense) strand whose 5′ end is discarded by MID is ejected, while the saved "guide" (antisense) strand
1334:
have been directed toward the design of successful dsRNA reagents that maximize gene knockdown but minimize "off-target" effects. Off-target effects arise when an introduced RNA has a base sequence that can pair with and thus reduce the expression of multiple genes. Such problems occur more
2955:
caused degradation of the par-1 message. It was thought that this degradation was triggered by single-stranded RNA (ssRNA), but two years later, in 1998, Fire and Mello discovered that this ability to silence the par-1 gene expression was actually triggered by double-stranded RNA (dsRNA).
1478:
membrane that facilitates crossover into the cytoplasm. Once inside the cell, the siRNA begins processing by the enzyme Dicer. Patisiran is administered by a healthcare professional through an intravenous infusion with dosing based on body weight. Warnings and precautions include risk of
1125:
that are specialized to react differently when the plant is exposed to different viruses. Even before the RNAi pathway was fully understood, it was known that induced gene silencing in plants could spread throughout the plant in a systemic effect and could be transferred from stock to
510:(affecting expression of several hundred genes). Friedman et al. estimate that >45,000 miRNA target sites within human mRNA 3′UTRs are conserved above background levels, and >60% of human protein-coding genes have been under selective pressure to maintain pairing to miRNAs.
2380:
Antiviral treatment is one of the earliest proposed RNAi-based medical applications, and two different types have been developed. The first type is to target viral RNAs. Many studies have shown that targeting viral RNAs can suppress the replication of numerous viruses, including
2996:(siRNA), it was possible to target the silencing of specific sequences in a gene, rather than silencing the entire gene. Only a year later, McCaffrey and colleagues demonstrated that this sequence-specific silencing had therapeutic applications by targeting a sequence from the
2831:(HTS) technology. RNAi HTS technology allows genome-wide loss-of-function screening and is broadly used in the identification of genes associated with specific phenotypes. This technology has been hailed as a potential second genomics wave, following the first genomics wave of
693:
is less stably paired to its complement, but strand selection is unaffected by the direction in which Dicer cleaves the dsRNA before RISC incorporation. Instead, the R2D2 protein may serve as the differentiating factor by binding the more-stable 5′ end of the passenger strand.
1380:
lack this reaction to exogenous dsRNA and are therefore a common model system for studying mammalian gene-knockdown effects. Specialized laboratory techniques have also been developed to improve the utility of RNAi in mammalian systems by avoiding the direct introduction of
2339:
In addition to LNPs, RNAi therapeutics have targeted delivery through siRNA conjugates (e.g., GalNAc, carbohydrates, peptides, aptamers, antibodies). Therapeutics using siRNA conjugates have been developed for rare or genetic diseases such as acute hepatic porphyria (AHP),
2919:, although it was not immediately recognized as related. Further investigation of the phenomenon in plants indicated that the downregulation was due to post-transcriptional inhibition of gene expression via an increased rate of mRNA degradation. This phenomenon was called
2253:). Even after entering the cells, repeated dosing is required since their effects are diluted at each cell division. In response to these potential issues and barriers, two approaches help facilitate siRNA delivery to target cells: lipid nanoparticles and conjugates.
2442:
way, such as by downgrading suppression of gene expression. In a single cancer cell, siRNA can cause dramatic suppression of gene expression with just several copies. This happens by silencing cancer-promoting genes with RNAi, as well as targeting an mRNA sequence.
1522:
and enters into liver cells. The medication is administered subcutaneously by a healthcare professional with dosing based on body weight. Warnings and precautions include risk of anaphylactic reactions, hepatic toxicity, renal toxicity and injection site reactions.
513:
Direct experiments show that a single miRNA can reduce the stability of hundreds of unique mRNAs. Other experiments show that a single miRNA may repress the production of hundreds of proteins, but that this repression often is relatively mild (less than 2-fold).
762:(also cytoplasmic bodies or GW bodies), which are regions with high rates of mRNA decay; miRNA activity is also clustered in P-bodies. Disruption of P-bodies decreases the efficiency of RNAi, suggesting that they are a critical site in the RNAi process.
2790:
system and poison insects feeding on them. Another approach involves spraying dsRNA like a conventional pesticide. This would allow faster adaptation to resistance. Such approaches would require low cost sources of dsRNAs that do not currently exist.
11274:
Gilbert MK, Majumdar R, Rajasekaran K, Chen ZY, Wei Q, Sickler CM, et al. (June 2018). "RNA interference-based silencing of the alpha-amylase (amy1) gene in
Aspergillus flavus decreases fungal growth and aflatoxin production in maize kernels".
260:
increases the binding affinity to siRNA by 10-fold. Association with TAF11 would convert the R2-D2-Initiator (RDI) complex into the RLC. R2D2 carries tandem double-stranded RNA-binding domains to recognize the thermodynamically stable terminus of
1269:
most likely already possessed an early RNAi pathway; the absence of the pathway in certain eukaryotes is thought to be a derived characteristic. This ancestral RNAi system probably contained at least one Dicer-like protein, one
Argonaute, one
524:
The effects of miRNA dysregulation of gene expression also seem to be important in neuropsychiatric disorders, such as schizophrenia, bipolar disorder, major depression, Parkinson's disease, Alzheimer's disease and autism spectrum disorders.
85:, which they published in 1998. Since the discovery of RNAi and its regulatory potentials, it has become evident that RNAi has immense potential in suppression of desired genes. RNAi is now known as precise, efficient, stable and better than
965:
target genes and induce direct mRNA cleavage by RISC, while animals' miRNAs tend to be more divergent in sequence and induce translational repression. This translational effect may be produced by inhibiting the interactions of translation
758:, translation of the mRNA target is not essential for RNAi-mediated degradation. Indeed, RNAi may be more effective against mRNA targets that are not translated. Argonaute proteins are localized to specific regions in the cytoplasm called
440:
derived from long dsRNA precursors differ from miRNAs in that miRNAs, especially those in animals, typically have incomplete base pairing to a target and inhibit the translation of many different mRNAs with similar sequences. In contrast,
11415:
Downie RC, Lin M, Corsi B, Ficke A, Lillemo M, Oliver RP, et al. (27 July 2021). "Septoria
Nodorum Blotch of Wheat: Disease Management and Resistance Breeding in the Face of Shifting Disease Dynamics and a Changing Environment".
598:
further trims it to a ~20nt miRNA duplex (pre-siRNAs also enter the pathway at this step). This duplex is then loaded into Ago to form the “pre-RISC(RNA induced silencing complex)” and the passenger strand is released to form active
2876:
The process of RNAi was referred to as "co-suppression" and "quelling" when observed prior to the knowledge of an RNA-related mechanism. The discovery of RNAi was preceded first by observations of transcriptional inhibition by
830:
protein Chp1, and a protein called Tas3 of unknown function. As a consequence, the induction and spread of heterochromatic regions requires the
Argonaute and RdRP proteins. Indeed, deletion of these genes in the fission yeast
2248:
must be used. If siRNA is transferred across the cell membrane, unintended toxicities can occur if therapeutic doses are not optimized, and siRNAs can exhibit off-target effects (e.g. unintended downregulation of genes with
2238:
To achieve the clinical potential of RNAi, siRNA must be efficiently transported to the cells of target tissues. However, there are various barriers that must be fixed before it can be used clinically. For example, "naked"
688:
kinetic analysis of RNAi in the presence and absence of ATP showed that ATP may be required to unwind and remove the cleaved mRNA strand from the RISC complex after catalysis. The guide strand tends to be the one whose
10403:
Rajput R, Khanna M, Kumar P, Kumar B, Sharma S, Gupta N, et al. (December 2012). "Small interfering RNA targeting the nonstructural gene 1 transcript inhibits influenza A virus replication in experimental mice".
431:(EBV). Thereafter, an increasing number of microRNAs have been described in viruses. VIRmiRNA is a comprehensive catalogue covering viral microRNA, their targets and anti-viral miRNAs (see also VIRmiRNA resource:
6956:"A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action"
492:. MREs are sequences to which miRNAs bind. These are prevalent motifs within 3′-UTRs. Among all regulatory motifs within the 3′-UTRs (e.g. including silencer regions), MREs make up about half of the motifs.
2230:
of the BERAs technology raises the question of the categorization of drugs having the same mechanism of action but being produced chemically or biologically. This lack of consistency should be addressed.
545:, that stimulates Dicer activity. This protein only binds long dsRNAs, but the mechanism producing this length specificity is unknown. This RNA-binding protein then facilitates the transfer of cleaved
379:. The phenomenon of RNAi, broadly defined, includes the endogenously induced gene silencing effects of miRNAs as well as silencing triggered by foreign dsRNA. Mature miRNAs are structurally similar to
6636:
DaRocha WD, Otsu K, Teixeira SM, Donelson JE (February 2004). "Tests of cytoplasmic RNA interference (RNAi) and construction of a tetracycline-inducible T7 promoter system in
Trypanosoma cruzi".
2372:, nicotine-free tobacco, decaffeinated coffee, nutrient fortified vegetation and hypoallergenic crops. The emerging use of RNAi has the potential to develop many other products for future use.
506:
and annotations, listed 28,645 entries in 271 biologic species. Of these, 1,917 miRNAs were in annotated human miRNA loci. miRNAs were predicted to have an average of about four hundred target
2499:
RNAi has been used to genetically engineer plants to produce lower levels of natural plant toxins. Such techniques take advantage of the stable and heritable RNAi phenotype in plant stocks.
10781:
Singer O, Marr RA, Rockenstein E, Crews L, Coufal NG, Gage FH, et al. (October 2005). "Targeting BACE1 with siRNAs ameliorates
Alzheimer disease neuropathology in a transgenic model".
4602:
Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, et al. (February 2005). "Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs".
147:
siRNAs. Each siRNA is unwound into two single-stranded RNAs (ssRNAs), the passenger (sense) strand and the guide (antisense) strand. The passenger strand is then cleaved by the protein
9805:
2770:
have been made to express dsRNA, carefully chosen to silence crucial genes in target pests. These dsRNAs are designed to affect only insects that express specific gene sequences. As a
2519:, a key enzyme in gossypol production, without affecting the enzyme's production in other parts of the plant, where gossypol is itself important in preventing damage from plant pests.
251:
studies on the genomes of multiple organisms suggest this length maximizes target-gene specificity and minimizes non-specific effects. These short double-stranded fragments are called
12981:
860:
in fission yeast, which may not be representative of activities in other genomic regions/organisms. In maintenance of existing heterochromatin regions, RITS forms a complex with
2487:
The mammalian safe framework has developed to incorporate siRNA as a tool to indicate viral contamination, which has allowed siRNA is create an intense innate immune response.
10325:
Li YC, Kong LH, Cheng BZ, Li KS (December 2005). "Construction of influenza virus siRNA expression vectors and their inhibitory effects on multiplication of influenza virus".
2368:
RNAi has been used for a variety of other applications including food, crops and insecticides. The use of the RNAi pathway has developed numerous products such as foods like
3004:
mice. Since then, multiple researchers have been attempting to expand the therapeutic applications of RNAi, specifically looking to target genes that cause various types of
871:. The formation of such a heterochromatin region, though not its maintenance, is Dicer-dependent, presumably because Dicer is required to generate the initial complement of
5814:
Irvine DV, Zaratiegui M, Tolia NH, Goto DB, Chitwood DH, Vaughn MW, et al. (August 2006). "Argonaute slicing is required for heterochromatic silencing and spreading".
5014:
Liu Q, Rand TA, Kalidas S, Du F, Kim HE, Smith DP, et al. (September 2003). "R2D2, a bridge between the initiation and effector steps of the
Drosophila RNAi pathway".
2599:
Animals exposed to RNAi at doses millions of times higher than anticipated human exposure levels show no adverse effects. RNAi has varying effects in different species of
11833:
Huesken D, Lange J, Mickanin C, Weiler J, Asselbergs F, Warner J, et al. (August 2005). "Design of a genome-wide siRNA library using an artificial neural network".
5922:
Volpe T, Schramke V, Hamilton GL, White SA, Teng G, Martienssen RA, et al. (2003). "RNA interference is required for normal centromere function in fission yeast".
1470:. Patisiran uses the RNAi cascade to suppress the gene that codes for TTR (transthryetin). Mutations in this gene may cause the misfolding of a protein responsible for
423:. The dsRNA portion of this pre-miRNA is bound and cleaved by Dicer to produce the mature miRNA molecule that can be integrated into the RISC complex; thus, miRNA and
1165:
this hypothesis has been challenged as poorly substantiated. Evidence for the existence of a functional antiviral RNAi pathway in mammalian cells has been presented.
6671:
Robinson KA, Beverley SM (May 2003). "Improvements in transfection efficiency and tests of RNA interference (RNAi) approaches in the protozoan parasite
Leishmania".
1007:
517:
The effects of miRNA dysregulation of gene expression seem to be important in cancer. For instance, in gastrointestinal cancers, nine miRNAs have been identified as
1145:
Although animals generally express fewer variants of the Dicer enzyme than plants, RNAi in some animals produces an antiviral response. In both juvenile and adult
1506:
designation for the treatment of acute hepatic porphyria (AHP) in
November 2019. By 2020, givosiran received EMA approval. Givosiran is an siRNA that breaks down
754:
It is not understood how the activated RISC complex locates complementary mRNAs within the cell. Although the cleavage process has been proposed to be linked to
4155:
2976:
injections had an effect on protein production, but double-stranded RNA successfully silenced the targeted gene. As a result of this work, they coined the term
2483:
evolved later than the innate, is composed mainly of highly specialized B and T cells that are trained to react to specific portions of pathogenic molecules.
1360:
Depending on the organism and experimental system, the exogenous RNA may be a long strand designed to be cleaved by Dicer, or short RNAs designed to serve as
1290:. This study also suggests that the RNA-binding Argonaute protein family, which is shared among eukaryotes, most archaea, and at least some bacteria (such as
944:
Organisms vary in their ability to take up foreign dsRNA and use it in the RNAi pathway. The effects of RNAi can be both systemic and heritable in plants and
867:
to the local genes and stably binds local methylated histones, acting co-transcriptionally to degrade any nascent pre-mRNA transcripts that are initiated by
12228:
Romano N, Macino G (November 1992). "Quelling: transient inactivation of gene expression in Neurospora crassa by transformation with homologous sequences".
11369:
Katoch R, Thakur N (March 2013). "Advances in RNA interference technology and its impact on nutritional improvement, disease and insect control in plants".
7550:
Wilkins C, Dishongh R, Moore SC, Whitt MA, Chow M, Machaca K (August 2005). "RNA interference is an antiviral defence mechanism in Caenorhabditis elegans".
1161:, as Argonaute proteins are upregulated in response to viruses and worms that overexpress components of the RNAi pathway are resistant to viral infection.
586:
Biogenesis: primary miRNAs (pri-miRNAs) are transcribed in the nucleus and fold back onto themselves as hairpins that are then trimmed in the nucleus by a
13053:
4653:
Selbach M, Schwanhäusser B, Thierfelder N, Fang Z, Khanin R, Rajewsky N (September 2008). "Widespread changes in protein synthesis induced by microRNAs".
2316:(apoE) in the low-density lipoprotein receptor (LDLR). In December 2020, Novartis announced that positive results from phase III efficacy studies deemed
1533:(PH1) in pediatric and adult populations. The drug is designed to reduce hepatic oxalate production and urinary oxalate levels through RNAi by targeting
1142:. These effects may be part of a generalized response to pathogens that downregulates any metabolic process in the host that aids the infection process.
13050:
RNA interference (RNAi) experiments and bioinformatics in C. elegans for education. From the Dolan DNA Learning Center of Cold Spring Harbor Laboratory.
1529:
was approved as a siRNA-based medication in 2020 for use in both the European Union and the United States. This medication is used for the treatment of
13119:
7105:"Systemic acquired silencing: transgene-specific post-transcriptional silencing is transmitted by grafting from silenced stocks to non-silenced scions"
220:. When the dsRNA is exogenous (coming from infection by a virus with an RNA genome or laboratory manipulations), the RNA is imported directly into the
9053:
8998:"Efficacy and safety of vutrisiran for patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: a randomized clinical trial"
856:
The mechanism by which the RITS complex induces heterochromatin formation and organization is not well understood. Most studies have focused on the
6126:"The assembly and maintenance of heterochromatin initiated by transgene repeats are independent of the RNA interference pathway in mammalian cells"
3314:
Macrae IJ, Zhou K, Li F, Repic A, Brooks AN, Cande WZ, et al. (January 2006). "Structural basis for double-stranded RNA processing by Dicer".
224:
and cleaved to short fragments by Dicer. The initiating dsRNA can also be endogenous (originating in the cell), as in pre-microRNAs expressed from
13087:
13054:
RNAi screens in C. elegans in a 96-well liquid format and their application to the systematic identification of genetic interactions (a protocol)
3373:
243:
protein Dicer, which binds and cleaves dsRNAs in plants, or short hairpin RNAs (shRNAs) in humans, to produce double-stranded fragments of 20–25
12685:
Elbashir S, Harborth J, Lendeckel W, et al. (2001). "Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells".
1286:
already possessed these components, which may then have had closer functional associations with generalized RNA degradation systems such as the
4095:
Sijen T, Steiner FA, Thijssen KL, Plasterk RH (January 2007). "Secondary siRNAs result from unprimed RNA synthesis and form a distinct class".
1218:
was shown to be involved in the regulation of several genes that control plant shape. In plants, the majority of genes regulated by miRNAs are
12472:"par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed"
10497:
Hu L, Wang Z, Hu C, Liu X, Yao L, Li W, et al. (2005). "Inhibition of Measles virus multiplication in cell culture by RNA interference".
10188:"Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference"
2405:. The other strategy is to block the initial viral entries by targeting the host cell genes. For example, suppression of chemokine receptors (
3456:
Bernstein E, Caudy AA, Hammond SM, Hannon GJ (January 2001). "Role for a bidentate ribonuclease in the initiation step of RNA interference".
13058:
684:
separated these two strands, the process proved to be ATP-independent and performed directly by the protein components of RISC. However, an
63:. The detailed study of each of these seemingly different processes elucidated that the identity of these phenomena were all actually RNAi.
6522:"RNA-directed transcriptional gene silencing in plants can be inherited independently of the RNA trigger and requires Met1 for maintenance"
2434:, providing a combinatorial therapeutic approach with chemotherapy. Another potential RNAi-based treatment is to inhibit cell invasion and
489:
5607:
Jakymiw A, Lian S, Eystathioy T, Li S, Satoh M, Hamel J, et al. (2005). "Disruption of P bodies impairs mammalian RNA interference".
2281:
as a drug delivery mechanism began in 2018 with the siRNA drug patisiran, developed by Alnylam Pharmaceuticals. Dicerna Pharmaceuticals,
10368:
Khanna M, Saxena L, Rajput R, Kumar B, Prasad R (2015). "Gene silencing: a therapeutic approach to combat influenza virus infections".
6067:"RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production"
4275:
Gregory RI, Chendrimada TP, Shiekhattar R (2006). "MicroRNA biogenesis: isolation and characterization of the microprocessor complex".
2462:-producing genes (e.g. BACE1 and APP) by RNAi can significantly reduced the amount of Aβ peptide which is correlated with the cause of
2980:. This discovery represented the first identification of the causative agent for the phenomenon. Fire and Mello were awarded the 2006
1510:
1 (ALAS1) mRNA in the liver. Breaking down ALAS1 mRNA prevents toxins (responsible for neurovisceral attacks and AHP disease) such as
295:, that stimulates Dicer activity. The mechanism producing this length specificity is unknown and this protein only binds long dsRNAs.
1534:
216:
and is initiated by short double-stranded RNA molecules in a cell's cytoplasm, where they interact with the catalytic RISC component
2811:
libraries and to predict their likely efficiency at gene knockdown. Mass genomic screening is widely seen as a promising method for
13330:
9195:"Patient Perspective on Acute Intermittent Porphyria with Frequent Attacks: A Disease with Intermittent and Chronic Manifestations"
2872:
that induce suppression of both transgene and endogenous gene expression, giving rise to the unpigmented white areas of the flower.
12181:"Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans"
4316:
Pfeffer S, Zavolan M, Grässer FA, Chien M, Russo JJ, Ju J, et al. (April 2004). "Identification of virus-encoded microRNAs".
2515:, making them unsuitable for human consumption. RNAi has been used to produce cotton stocks whose seeds contain reduced levels of
853:. In some cases, similar processes associated with histone modification have been observed to transcriptionally upregulate genes.
6823:
5714:
Holmquist GP, Ashley T (2006). "Chromosome organization and chromatin modification: influence on genome function and evolution".
10575:"Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication, by Martínez et al"
9396:
9342:
6897:"Translational repression is sufficient for gene silencing by bacterial small noncoding RNAs in the absence of mRNA destruction"
2937:
After these initial observations in plants, laboratories searched for this phenomenon in other organisms. The first instance of
2566:, while virus-induced gene silencing (VIGS, a subtype of RNAi) was used by Scofield et al. 2005 to investigate the mechanism of
13170:
13112:
2715:
2709:
2697:
2687:
2328:
11638:"RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design"
11231:
Niggeweg R, Michael AJ, Martin C (June 2004). "Engineering plants with increased levels of the antioxidant chlorogenic acid".
738:(a process that allows more than one atom to share an electron by passing it back and forth) between the 5′ nucleotide in the
12317:
12053:
12026:
11928:
9770:
5122:
4292:
3912:
2981:
2554:
to improve photosynthesis. SBEIIa and SBEIIb genes in wheat have been targeted in wheat in order to produce higher levels of
2244:
sites) nature, unmodified siRNA molecules cannot readily enter the cells through the cell membrane. Therefore, artificial or
819:
480:
often contain regulatory sequences that post-transcriptionally cause RNAi. Such 3′-UTRs often contain both binding sites for
72:
11694:
9509:"RNA-based drugs and regulation: Toward a necessary evolution of the definitions issued from the European union legislation"
5431:
Sen G, Wehrman T, Blau H (2005). "mRNA translation is not a prerequisite for small interfering RNA-mediated mRNA cleavage".
11096:
Whitehead KA, Dahlman JE, Langer RS, Anderson DG (2011). "Silencing or stimulation? siRNA delivery and the immune system".
8324:"Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments"
2301:
1364:
substrates. In most mammalian cells, shorter RNAs are used because long double-stranded RNA molecules induce the mammalian
1255:
1037:, possibly due to the evolution of a novel pathway with similar function, or to the lack of selective advantage in certain
1033:
are missing RNAi pathways indicates that proteins required for RNA silencing have been lost independently from many fungal
880:
is not clear, as heterochromatin maintenance in mammalian cells may be independent of the components of the RNAi pathway.
12982:"Novartis receives EU approval for Leqvio(inclisiran), a first-in-class siRNA to lower cholesterol with two doses a year"
10122:"Application of food and feed safety assessment principles to evaluate transgenic approaches to gene modulation in crops"
2250:
2245:
1192:
miRNAs, are most important in translational repression and in the regulation of development, especially on the timing of
864:
802:
Components of the RNAi pathway are used in many eukaryotes in the maintenance of the organization and structure of their
653:
11876:
Ge G, Wong GW, Luo B (October 2005). "Prediction of siRNA knockdown efficiency using artificial neural network models".
11427:
9464:
13002:
12435:
Ratcliff F, Harrison BD, Baulcombe DC (June 1997). "A similarity between viral defense and gene silencing in plants".
6579:"MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function"
13105:
11326:
Katoch R, Thakur N (March 2013). "RNA interference: a promising technique for the improvement of traditional crops".
4416:
Pillai RS, Bhattacharyya SN, Filipowicz W (2007). "Repression of protein synthesis by miRNAs: how many mechanisms?".
384:
12513:"Cosuppression in Drosophila: gene silencing of Alcohol dehydrogenase by white-Adh transgenes is Polycomb dependent"
1335:
frequently when the dsRNA contains repetitive sequences. It has been estimated from studying the genomes of humans,
1226:
during development by modulating the expression of key regulatory genes, including transcription factors as well as
4041:
Pak J, Fire A (January 2007). "Distinct populations of primary and secondary effectors during RNAi in C. elegans".
2799:
Approaches to the design of genome-wide RNAi libraries can require more sophistication than the design of a single
2774:, in 2009 a study showed RNAs that could kill any one of four fruit fly species while not harming the other three.
13081:: a database of phenotypes from RNA interference screening experiments in Drosophila melanogaster and Homo sapiens
11597:"Corn rootworm-active RNA DvSnf7: Repeat dose oral toxicology assessment in support of human and mammalian safety"
12045:
Optimal High-Throughput Screening: Practical Experimental Design and Data Analysis for Genome-scale RNAi Research
11636:
Terenius O, Papanicolaou A, Garbutt JS, Eleftherianos I, Huvenne H, Kanginakudru S, et al. (February 2011).
11192:"Design of tomato fruits with reduced allergenicity by dsRNAi-mediated inhibition of ns-LTP (Lyc e 3) expression"
10614:
Fuchs U, Damm-Welk C, Borkhardt A (August 2004). "Silencing of disease-related genes by small interfering RNAs".
9360:
9071:
2431:
1545:
473:
468:
12660:
10042:"Targeted gene suppression by RNA interference: an efficient method for production of high-amylose potato lines"
4863:"Micro spies from the brain to the periphery: new clues from studies on microRNAs in neuropsychiatric disorders"
2885:
plants, and more directly by reports of unexpected outcomes in experiments performed by plant scientists in the
236:, then exported to the cytoplasm. Thus, the two dsRNA pathways, exogenous and endogenous, converge at the RISC.
93:
produced intracellularly by an expression vector may be developed and find utility as novel therapeutic agents.
5523:
Sen G, Blau H (2005). "Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies".
2992:
Just after Fire and Mello's ground-breaking discovery, Elbashir et al. discovered, by using synthetically made
2839:
13043:
5323:
Tomari Y, Matranga C, Haley B, Martinez N, Zamore PD (November 2004). "A protein sensor for siRNA asymmetry".
5276:"Short interfering RNA strand selection is independent of dsRNA processing polarity during RNAi in Drosophila"
3047:
received EMA approval in 2020 for the treatment of high cholesterol and is currently under review by the FDA.
51:, through translational or transcriptional repression. Historically, RNAi was known by other names, including
13259:
7914:
3086:
2324:
1054:
systems in prokaryotes are analogous to eukaryotic RNAi systems, although none of the protein components are
787:
600:
213:
152:
8618:"Absence of non-specific effects of RNA interference triggered by long double-stranded RNA in mouse oocytes"
13387:
10965:"RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model"
9089:
Gonzalez-Aseguinolaza G (11 June 2020). "Givosiran — Running RNA Interference to Fight Porphyria Attacks".
1507:
1275:
966:
573:
319:
11595:
Petrick JS, Friedrich GE, Carleton SM, Kessenich CR, Silvanovich A, Zhang Y, et al. (November 2016).
10651:"RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines"
6026:"RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing"
912:
strains indicating that A→I RNA editing may counteract RNAi silencing of endogenous genes and transgenes.
13444:
13198:
13034:
11768:
9824:
3017:
1262:
660:. As the fragments produced by Dicer are double-stranded, they could each in theory produce a functional
10873:
Piedrahita D, Hernández I, López-Tobón A, Fedorov D, Obara B, Manjunath BS, et al. (October 2010).
9569:
Kanasty R, Dorkin JR, Vegas A, Anderson D (November 2013). "Delivery materials for siRNA therapeutics".
8373:"dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference"
3945:"RDE-4 preferentially binds long dsRNA and its dimerization is necessary for cleavage of dsRNA to siRNA"
204:
domains are colored green, the PAZ domain yellow, the platform domain red, and the connector helix blue.
13396:
13084:
11777:
11711:
8661:, Agami R (April 2002). "A system for stable expression of short interfering RNAs in mammalian cells".
3560:"RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals"
13013:
7189:"Suppression of post-transcriptional gene silencing by a plant viral protein localized in the nucleus"
3381:
228:
in the genome. The primary transcripts from such genes are first processed to form the characteristic
13429:
13029:
11702:
7970:"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14"
7285:
Katiyar-Agarwal S, Morgan R, Dahlbeck D, Borsani O, Villegas A, Zhu JK, et al. (November 2006).
5654:(2000). "An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells".
4761:
Palmero EI, de Campos SG, Campos M, de Souza NC, Guerreiro ID, Carvalho AL, et al. (July 2011).
2828:
2804:
1556:
1471:
1341:
1115:, especially in plants where it may also prevent the self-propagation of transposons. Plants such as
833:
12784:
10826:"Allele-specific RNAi mitigates phenotypic progression in a transgenic model of Alzheimer's disease"
7054:
Blevins T, Rajeswaran R, Shivaprasad PV, Beknazariants D, Si-Ammour A, Park HS, et al. (2006).
5700:
3500:
3417:
3219:"Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes"
2972:. In investigating the regulation of muscle protein production, they observed that neither mRNA nor
1555:
Other investigational drugs using RNAi that are being developed by pharmaceutical companies such as
1349:
have substantial off-target effects. A multitude of software tools have been developed implementing
13439:
13128:
11911:
Janitz M, Vanhecke D, Lehrach H (2006). "High-Throughput RNA Interference in Functional Genomics".
11418:
9414:
Garrelfs SF, Frishberg Y, Hulton SA, Koren MJ, O'Riordan WD, Cochat P, et al. (1 April 2021).
8949:
Garrelfs SF, Frishberg Y, Hulton SA, Koren MJ, O'Riordan WD, Cochat P, et al. (1 April 2021).
7699:
Cullen BR (June 2006). "Is RNA interference involved in intrinsic antiviral immunity in mammals?".
2567:
2278:
1475:
1001:
815:
11141:"Engineering cottonseed for use in human nutrition by tissue-specific reduction of toxic gossypol"
8996:
Adams D, Tournev IL, Taylor MS, Coelho T, Planté-Bordeneuve V, Berk JL, et al. (March 2023).
8843:
Adams D, Gonzalez-Duarte A, O'Riordan WD, Yang CC, Ueda M, Kristen AV, et al. (5 July 2018).
8471:"siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference"
8322:
Munkácsy G, Sztupinszki Z, Herman P, Bán B, Pénzváltó Z, Szarvas N, et al. (September 2016).
7344:
Fritz JH, Girardin SE, Philpott DJ (June 2006). "Innate immune defense through RNA interference".
6315:
Yang W, Chendrimada TP, Wang Q, Higuchi M, Seeburg PH, Shiekhattar R, et al. (January 2006).
919:
Illustration of the major differences between plant and animal gene silencing. Natively expressed
13251:
13186:
7238:"Double-stranded RNA binding may be a general plant RNA viral strategy to suppress RNA silencing"
2941:
silencing in animals was documented in 1996, when Guo and Kemphues observed that, by introducing
2748:
2516:
1560:
1467:
1419:
447:
383:
produced from exogenous dsRNA, but before reaching maturity, miRNAs must first undergo extensive
10526:"VIRmiRNA: a comprehensive resource for experimentally validated viral miRNAs and their targets"
8105:
Jones-Rhoades MW, Bartel DP, Bartel B (2006). "MicroRNAS and their regulatory roles in plants".
4369:"VIRmiRNA: a comprehensive resource for experimentally validated viral miRNAs and their targets"
2782:
Alternatively dsRNA can be supplied without genetic engineering. One approach is to add them to
1427:
1322:
decrease in expression may show the physiological role or impact of the targeted gene products.
13405:
13355:
11483:
Ivashuta S, Zhang Y, Wiggins BE, Ramaseshadri P, Segers GC, Johnson S, et al. (May 2015).
8567:
Reynolds A, Anderson EM, Vermeulen A, Fedorov Y, Robinson K, Leake D, et al. (June 2006).
8009:
Palatnik JF, Allen E, Wu X, Schommer C, Schwab R, Carrington JC, et al. (September 2003).
5376:"Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein"
3592:
Vermeulen A, Behlen L, Reynolds A, Wolfson A, Marshall WS, Karpilow J, et al. (May 2005).
3412:
3021:
2951:
2756:
2467:
2463:
1297:
795:
755:
677:
587:
535:
428:
408:
285:
273:
81:
13242:
12018:
12011:
9753:
Leung AK, Tam YY, Cullis PR (2014). "Lipid Nanoparticles for Short Interfering RNA Delivery".
8781:
Ventura A, Meissner A, Dillon CP, McManus M, Sharp PA, Van Parijs L, et al. (July 2004).
6765:
Drinnenberg IA, Weinberg DE, Xie KT, Mower JP, Wolfe KH, Fink GR, et al. (October 2009).
2466:. In addition, this silencing-based approaches also provide promising results in treatment of
2296:
Other recent applications include two FDA approved COVID-19 vaccines: mRNA-1273, developed by
960:(channels in the cell walls that enable communication and transport). Heritability comes from
12333:
Covey S, Al-Kaff N, Lángara A, Turner D (1997). "Plants combat infection by gene silencing".
11109:
9482:
9132:
8118:
6190:
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2808:
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2563:
2471:
2345:
2240:
1530:
1394:
1382:
1361:
1354:
1346:
1331:
1135:
953:
924:
908:
from RNAi pathway components. Further support for this model comes from studies on ADAR-null
905:
872:
861:
779:
747:
739:
698:
661:
657:
569:
565:
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typically base-pair perfectly and induce mRNA cleavage only in a single, specific target. In
442:
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380:
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315:
311:
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303:
277:
269:
261:
256:
252:
109:
105:
12926:"Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles"
12839:
Wall NR, Shi Y (October 2003). "Small RNA: can RNA interference be exploited for therapy?".
1401:
vector systems allowing the inducible activation or deactivation of transcription, known as
13311:
13303:
13268:
13007:
12937:
12749:
12694:
12617:
12606:"Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans"
12389:
12342:
12133:
11719:
11649:
11549:
11284:
10976:
9661:
De-Souza EA, Camara H, Salgueiro WG, Moro RP, Knittel TL, Tonon G, et al. (May 2019).
9578:
9378:
8794:
8735:
8670:
8022:
7926:
7869:
7812:
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7614:
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3013:
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2504:
1495:
1279:
1219:
1214:
1197:
1169:
1117:
735:
556:
this initiation response is amplified through the synthesis of a population of 'secondary'
302:
this initiation response is amplified through the synthesis of a population of 'secondary'
11978:
7495:"Animal virus replication and RNAi-mediated antiviral silencing in Caenorhabditis elegans"
2542:
fungal growth in maize which would have otherwise contaminated the kernels with dangerous
1168:
Other functions for RNAi in mammalian viruses also exist, such as miRNAs expressed by the
427:
share the same downstream cellular machinery. First, viral encoded miRNA was described in
8:
13346:
13322:
13069:
10278:"A retrovirus-based system to stably silence hepatitis B virus genes by RNA interference"
9991:
Balwani M, Sardh E, Ventura P, Peiró PA, Rees DC, Stölzel U, et al. (11 June 2020).
9891:
Fitzgerald K, White S, Borodovsky A, Bettencourt BR, Strahs A, Clausen V (January 2017).
8902:
Balwani M, Sardh E, Ventura P, Peiró PA, Rees DC, Stölzel U, et al. (11 June 2020).
8569:"Induction of the interferon response by siRNA is cell type- and duplex length-dependent"
8520:"siVirus: web-based antiviral siRNA design software for highly divergent viral sequences"
6317:"Modulation of microRNA processing and expression through RNA editing by ADAR deaminases"
4502:"Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways"
2703:
2631:
2559:
1511:
1051:
1034:
901:
838:
641:
624:
338:
272:
base-pair to their target mRNA and cleave it, thereby preventing it from being used as a
136:
48:
13024:
12941:
12753:
12698:
12621:
12393:
12346:
12137:
11653:
11553:
11288:
10980:
10924:"Viral-based modelling and correction of neurodegenerative diseases by RNA interference"
9582:
8798:
8739:
8674:
8026:
7930:
7873:
7816:
7759:
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7563:
7510:
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5882:
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5391:
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5291:
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4615:
4329:
4108:
4054:
3857:
3651:
3527:
3469:
3403:
Bagasra O, Prilliman KR (August 2004). "RNA interference: the molecular immune system".
3327:
3282:
3183:
3158:
3125:
3043:
later won FDA approval for the treatment of AHP and PH1 in 2019 and 2020, respectively.
1085:
Please help update this article to reflect recent events or newly available information.
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Le LQ, Lorenz Y, Scheurer S, Fötisch K, Enrique E, Bartra J, et al. (March 2006).
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Berkhout B (April 2004). "RNA interference as an antiviral approach: targeting HIV-1".
10022:
9968:
9941:
9917:
9892:
9868:
9843:
9806:"Big Pharma's Turn On RNAi Shows That New Technologies Don't Guarantee R&D Success"
9781:
9762:
9735:
9710:
Li W, Szoka FC (24 March 2007). "Lipid-based nanoparticles for nucleic acid delivery".
9687:
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7602:
7583:
7527:
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7418:
7389:"RNAi is an antiviral immune response against a dsRNA virus in Drosophila melanogaster"
7369:
7321:
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7262:
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7129:
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7055:
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4635:
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4393:
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4128:
4074:
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3969:
3944:
3877:
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3695:
3668:
3635:
3618:
3593:
3547:
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3438:
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3196:
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paper reported a potent gene silencing effect after injecting double stranded RNA into
2771:
2671:
2637:
2539:
2290:
1413:
1154:
1122:
1055:
992:
lack the RNAi pathway entirely. Most or all of the components are also missing in some
857:
710:
503:
388:
151:(Ago2). The passenger strand is degraded and the guide strand is incorporated into the
12882:
Sah D (2006). "Therapeutic potential of RNA interference for neurological disorders".
12852:
12529:
12512:
12205:
12180:
12156:
12121:
12097:
12070:
11969:
10999:
10964:
10448:"Advancements in Nucleic Acid Based Therapeutics against Respiratory Viral Infections"
9163:
8817:
8782:
8758:
8723:
8495:
8470:
8446:
8421:
8300:
8264:
8239:
7213:
7188:
7165:
7056:"Four plant Dicers mediate viral small RNA biogenesis and DNA virus induced silencing"
6870:
6684:
6546:
6521:
6240:
6223:
6101:
6066:
5757:
Verdel A, Jia S, Gerber S, Sugiyama T, Gygi S, Grewal SI, et al. (January 2004).
5251:
5234:
4518:
4501:
4477:
4452:
3576:
3559:
3514:
Siomi H, Siomi MC (January 2009). "On the road to reading the RNA-interference code".
2430:). It has also been proposed that RNAi can enhance the sensitivity of cancer cells to
2262:
mechanisms have become an increasing source of encasing nucleic acids and may include
1466:
is the first double stranded siRNA-based medication approved in 2018 and developed by
13140:
12963:
12921:
12899:
12856:
12821:
12765:
12710:
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12578:
12534:
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12452:
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11113:
11053:
11004:
10963:
Harper SQ, Staber PD, He X, Eliason SL, Martins IH, Mao Q, et al. (April 2005).
10945:
10904:
10855:
10798:
10713:
10672:
10631:
10596:
10591:
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10555:
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7895:
7838:
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7742:
Maillard PV, Ciaudo C, Marchais A, Li Y, Jay F, Ding SW, et al. (October 2013).
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7640:
7575:
7532:
7475:
7410:
7405:
7388:
7361:
7326:
7267:
7218:
7169:
7134:
7085:
7036:
6987:
6936:
6854:
6804:
6747:
6742:
6707:
6688:
6653:
6649:
6618:
6551:
6502:
6446:
6397:
6346:
6294:
6245:
6204:
6155:
6106:
6047:
6006:
5965:
Li LC, Okino ST, Zhao H, Pookot D, Place RF, Urakami S, et al. (November 2006).
5939:
5896:
5867:"Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi"
5839:
5796:
5731:
5681:
5624:
5589:
5540:
5505:
5448:
5444:
5413:
5348:
5305:
5256:
5207:
5169:
5118:
5111:
5088:
5039:
4996:
4945:
4894:
4843:
4792:
4743:
4678:
4627:
4584:
4523:
4482:
4433:
4398:
4341:
4298:
4288:
4257:
4221:
4147:
4120:
4066:
4012:
3974:
3918:
3908:
3869:
3826:
3777:
3725:
3673:
3623:
3581:
3551:
3539:
3481:
3430:
3339:
3296:
3240:
3188:
3139:
2915:
2902:
2812:
2455:
1487:
1189:
988:
702:
347:
86:
13097:
12868:
12590:
12376:
Kumagai MH, Donson J, della-Cioppa G, Harvey D, Hanley K, Grill LK (February 1995).
12362:
12257:
11862:
11743:
11695:"Bugs Are Not to Be Silenced: Small RNA Pathways and Antiviral Responses in Insects"
11398:
11355:
11260:
11125:
10824:
Rodríguez-Lebrón E, Gouvion CM, Moore SA, Davidson BL, Paulson HL (September 2009).
10354:
10311:
8708:
8134:
7954:
7728:
7422:
7373:
6866:
6563:
5951:
5851:
5743:
5636:
5460:
5360:
5219:
5109:
Lodish H, Berk A, Matsudaira P, Kaiser CA, Krieger M, Scott MP, et al. (2004).
5051:
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4353:
4233:
4078:
4024:
3881:
3844:
Ahlquist P (May 2002). "RNA-dependent RNA polymerases, viruses, and RNA silencing".
3351:
3099:
1567:, and Sylentis. These medications cover a variety of targets via RNAi and diseases.
28:
delivery of designed shRNAs and the mechanism of RNA interference in mammalian cells
13374:
13018:
12953:
12945:
12891:
12848:
12811:
12777:
12757:
12702:
12645:
12625:
12568:
12524:
12483:
12444:
12407:
12397:
12350:
12288:
12237:
12200:
12192:
12151:
12141:
12092:
12082:
11995:
11973:
11965:
11916:
11885:
11842:
11797:
11781:
11715:
11665:
11661:
11657:
11608:
11567:
11557:
11504:
11496:
11439:
11431:
11378:
11335:
11312:
11292:
11240:
11203:
11162:
11152:
11139:
Sunilkumar G, Campbell LM, Puckhaber L, Stipanovic RD, Rathore KS (November 2006).
11105:
11043:
11035:
10994:
10984:
10935:
10894:
10890:
10886:
10845:
10837:
10810:
10790:
10761:
10703:
10662:
10623:
10586:
10545:
10537:
10469:
10459:
10413:
10377:
10334:
10289:
10248:
10240:
10199:
10133:
10092:
10053:
10004:
9963:
9953:
9912:
9904:
9863:
9855:
9776:
9758:
9739:
9719:
9682:
9674:
9633:
9625:
9586:
9538:
9520:
9427:
9314:
9306:
9265:
9255:
9214:
9206:
9159:
9098:
9017:
9009:
8962:
8915:
8866:
8856:
8812:
8802:
8753:
8743:
8686:
8678:
8629:
8588:
8580:
8539:
8531:
8490:
8482:
8441:
8433:
8392:
8384:
8343:
8335:
8296:
8259:
8251:
8210:
8202:
8161:
8114:
8077:
8030:
7981:
7934:
7885:
7877:
7828:
7820:
7771:
7763:
7708:
7671:
7630:
7622:
7603:"The interplay between virus infection and the cellular RNA interference machinery"
7587:
7567:
7522:
7514:
7465:
7457:
7400:
7353:
7316:
7306:
7257:
7249:
7208:
7200:
7161:
7152:
Voinnet O (August 2001). "RNA silencing as a plant immune system against viruses".
7124:
7116:
7075:
7067:
7026:
7018:
6977:
6967:
6926:
6916:
6846:
6794:
6786:
6737:
6727:
6680:
6645:
6608:
6598:
6541:
6492:
6482:
6436:
6428:
6387:
6377:
6364:
Yang W, Wang Q, Howell KL, Lee JT, Cho DS, Murray JM, et al. (February 2005).
6336:
6328:
6284:
6276:
6235:
6194:
6186:
6145:
6137:
6096:
6086:
6037:
6024:
Noma K, Sugiyama T, Cam H, Verdel A, Zofall M, Jia S, et al. (November 2004).
5996:
5986:
5931:
5908:
5886:
5831:
5786:
5778:
5723:
5693:
5673:
5656:
5616:
5579:
5552:
5532:
5495:
5487:
5440:
5403:
5395:
5340:
5295:
5246:
5199:
5159:
5151:
5078:
5031:
4986:
4981:
4976:
4964:
4935:
4925:
4884:
4874:
4833:
4823:
4782:
4774:
4733:
4725:
4690:
4670:
4639:
4619:
4574:
4566:
4513:
4472:
4464:
4453:"Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways"
4425:
4388:
4380:
4333:
4280:
4249:
4211:
4203:
4139:
4132:
4112:
4058:
4004:
3964:
3956:
3900:
3861:
3816:
3808:
3795:
Liang C, Wang Y, Murota Y, Liu X, Smith D, Siomi MC, et al. (September 2015).
3767:
3759:
3715:
3707:
3663:
3655:
3613:
3605:
3571:
3531:
3493:
3473:
3442:
3422:
3331:
3286:
3230:
3200:
3178:
3170:
3129:
3112:
2767:
2313:
1292:
1243:
1127:
1038:
1013:
982:
97:
12722:
12448:
10875:"Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice"
10057:
9013:
8658:
8050:
7881:
7626:
7493:
Lu R, Maduro M, Li F, Li HW, Broitman-Maduro G, Li WX, et al. (August 2005).
3020:. Four years later the first-in-human Phase I clinical trial was started, using a
13277:
13091:
13047:
12605:
12087:
11562:
11435:
11339:
9310:
9022:
6708:"Lineage-specific loss and divergence of functionally linked genes in eukaryotes"
5865:
Volpe TA, Kidner C, Hall IM, Teng G, Grewal SI, Martienssen RA (September 2002).
3812:
3291:
3266:
2832:
2725:
2681:
2659:
2581:
2577:
2401:, respiratory syncytial virus (RSV), SARS coronavirus (SARS-CoV), adenovirus and
2398:
2357:
1515:
1499:
1369:
1287:
1205:
1173:
1150:
1108:
970:
961:
811:
706:
697:
The structural basis for binding of RNA to the Argonaute protein was examined by
372:
163:
44:
11613:
11596:
10692:"CXCR4 knockdown by small interfering RNA abrogates breast tumor growth in vivo"
10041:
9958:
9663:"RNA interference may result in unexpected phenotypes in Caenorhabditis elegans"
8903:
8634:
8617:
8166:
8149:
8082:
8065:
7676:
7659:
4240:
Zhao Y, Srivastava D (April 2007). "A developmental view of microRNA function".
3904:
3899:. Advances in Experimental Medicine and Biology. Vol. 887. pp. 15–30.
3748:"Anatomy of RISC: how do small RNAs and chaperones activate Argonaute proteins?"
2815:
and has triggered the development of high-throughput screening methods based on
2653:
are models that have been widely used to learn how RNAi works within particular
1518:(PBG) from accumulating. To facilitate entry into the cytoplasm, givosiran uses
822:(RITS), and is carried out by a complex of proteins called the RITS complex. In
607:
533:
Exogenous dsRNA is detected and bound by an effector protein, known as RDE-4 in
283:
Exogenous dsRNA is detected and bound by an effector protein, known as RDE-4 in
13222:
12737:
12382:
Proceedings of the National Academy of Sciences of the United States of America
12126:
Proceedings of the National Academy of Sciences of the United States of America
11889:
11145:
Proceedings of the National Academy of Sciences of the United States of America
10969:
Proceedings of the National Academy of Sciences of the United States of America
10766:
10749:
8787:
Proceedings of the National Academy of Sciences of the United States of America
8728:
Proceedings of the National Academy of Sciences of the United States of America
7291:
Proceedings of the National Academy of Sciences of the United States of America
7120:
6901:
Proceedings of the National Academy of Sciences of the United States of America
6712:
Proceedings of the National Academy of Sciences of the United States of America
6583:
Proceedings of the National Academy of Sciences of the United States of America
6071:
Proceedings of the National Academy of Sciences of the United States of America
5971:
Proceedings of the National Academy of Sciences of the United States of America
5651:
5190:
Haley B, Zamore PD (July 2004). "Kinetic analysis of the RNAi enzyme complex".
5083:
5067:"Human RISC couples microRNA biogenesis and posttranscriptional gene silencing"
5066:
4914:"The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders"
4284:
4253:
3235:
3218:
3078:
3064:
3009:
2957:
2864:
plants in which genes for pigmentation are silenced by RNAi. The left plant is
2752:
2649:
2558:
in order to improve bowel function, and Travella et al. 2006 employed RNAi for
2435:
1313:
997:
868:
746:
residue. This site is thought to form a nucleation site for the binding of the
368:
330:
248:
225:
209:
68:
12895:
11637:
11444:
11382:
11296:
10541:
10294:
10277:
10137:
10120:
Parrott W, Chassy B, Ligon J, Meyer L, Patrick J, Zhou J, et al. (2010).
9993:"Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria"
9723:
9525:
9210:
8904:"Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria"
8206:
7438:"RNA interference directs innate immunity against viruses in adult Drosophila"
7436:
Wang XH, Aliyari R, Li WX, Li HW, Kim K, Carthew R, et al. (April 2006).
7204:
7022:
6850:
6366:"ADAR1 RNA deaminase limits short interfering RNA efficacy in mammalian cells"
5935:
5300:
5275:
4812:"Epigenetic reduction of DNA repair in progression to gastrointestinal cancer"
4763:"Mechanisms and role of microRNA deregulation in cancer onset and progression"
4429:
4384:
3426:
3134:
3107:
2856:
2675:
three, as found by Lewis et al. 2016 and Hain et al. 2010. In the case of the
590:
to form a ~60-70nt hairpin pre-RNA. This pre-miRNA is transported through the
13423:
13194:
13162:
12917:
12604:
Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC (February 1998).
12122:"Inhibition of gene expression in plant cells by expression of antisense RNA"
11793:
11727:
11453:
10627:
9534:
9193:
Simon A, Pompilus F, Querbes W, Wei A, Strzok S, Penz C, et al. (2018).
9031:
8974:
8927:
8191:"On the origin and functions of RNA-mediated silencing: from protists to man"
7357:
5155:
4930:
4879:
4860:
3159:"Antisense RNA gene therapy for studying and modulating biological processes"
2973:
2946:
2886:
2535:
2402:
2369:
2271:
1549:
1230:. In many organisms, including humans, miRNAs are linked to the formation of
1227:
1193:
1030:
957:
915:
850:
823:
791:
507:
477:
167:
90:
12146:
11920:
11157:
10989:
10338:
10121:
10040:
Andersson M, Melander M, Pojmark P, Larsson H, Bülow L, Hofvander P (2006).
8997:
8950:
8807:
8748:
8682:
8371:
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S (July 2005).
8255:
7938:
7824:
7767:
7461:
7311:
6921:
6790:
6603:
6124:
Wang F, Koyama N, Nishida H, Haraguchi T, Reith W, Tsukamoto T (June 2006).
6091:
5991:
5891:
5866:
5835:
5782:
5344:
5140:"Cleavage of the siRNA passenger strand during RISC assembly in human cells"
5035:
4337:
4143:
4116:
4062:
4008:
3865:
3335:
1998:
Choroidal neovascularization, diabetic retinopathy, diabetic macular oedema
1050:
miRNAs because the Dicer enzyme is not involved. It has been suggested that
13434:
12967:
12903:
12860:
12825:
12816:
12799:
12769:
12714:
12582:
12456:
12402:
12214:
12165:
12106:
11987:
11938:
11897:
11854:
11811:
11735:
11679:
11670:
11622:
11581:
11518:
11500:
11461:
11390:
11347:
11304:
11252:
11217:
11176:
11117:
11057:
11008:
10949:
10908:
10859:
10802:
10717:
10708:
10691:
10676:
10667:
10650:
10635:
10600:
10559:
10510:
10483:
10425:
10389:
10346:
10303:
10262:
10213:
10204:
10187:
10172:
10145:
10106:
10065:
10018:
9977:
9926:
9877:
9790:
9731:
9696:
9647:
9598:
9552:
9441:
9328:
9279:
9228:
9171:
9110:
9039:
8982:
8935:
8880:
8826:
8767:
8724:"CRE recombinase-inducible RNA interference mediated by lentiviral vectors"
8700:
8643:
8602:
8553:
8504:
8455:
8406:
8357:
8308:
8273:
8240:"Comparative genomics and evolution of proteins involved in RNA metabolism"
8224:
8175:
8126:
8091:
8042:
7946:
7899:
7842:
7785:
7720:
7685:
7644:
7579:
7536:
7479:
7414:
7365:
7330:
7271:
7222:
7173:
7089:
7040:
6991:
6940:
6858:
6808:
6751:
6732:
6692:
6657:
6622:
6555:
6506:
6450:
6417:"Editor meets silencer: crosstalk between RNA editing and RNA interference"
6401:
6382:
6350:
6298:
6249:
6208:
6159:
6110:
6051:
6010:
5943:
5900:
5843:
5800:
5735:
5685:
5628:
5593:
5544:
5509:
5452:
5417:
5352:
5309:
5260:
5211:
5173:
5092:
5043:
5000:
4991:
4949:
4898:
4847:
4796:
4747:
4704:
Baek D, Villén J, Shin C, Camargo FD, Gygi SP, Bartel DP (September 2008).
4682:
4631:
4588:
4527:
4486:
4437:
4402:
4345:
4302:
4261:
4225:
4151:
4124:
4070:
4016:
3978:
3922:
3873:
3830:
3781:
3729:
3677:
3627:
3585:
3543:
3485:
3434:
3343:
3300:
3244:
3192:
3143:
3001:
2942:
2906:
2459:
2446:
more efficiently. RNAi uptake and regulation is controlled by the kidneys.
2422:
2353:
2321:
1548:
stage 1 or 2. Vutrisiran is designed to break down the mRNA that codes for
1386:
1271:
1258:
1223:
1212:
in 1993. In plants this function was discovered when the "JAW microRNA" of
827:
717:
676:
is degraded during RISC activation. Although it was first believed that an
649:
591:
396:
240:
233:
175:
159:
12637:
12573:
12556:
12538:
12497:
12421:
12378:"Cytoplasmic inhibition of carotenoid biosynthesis with virus-derived RNA"
12249:
10940:
10923:
10446:
Asha K, Kumar P, Sanicas M, Meseko CA, Khanna M, Kumar B (December 2018).
10417:
10009:
9992:
9908:
9859:
9755:
Nonviral Vectors for Gene Therapy - Lipid- and Polymer-based Gene Transfer
9432:
9415:
8966:
8919:
8861:
8845:"Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis"
8844:
7995:
7801:"RNA interference functions as an antiviral immunity mechanism in mammals"
7236:
Mérai Z, Kerényi Z, Kertész S, Magna M, Lakatos L, Silhavy D (June 2006).
7138:
6972:
6487:
4828:
4570:
4500:
Lee Y, Nakahara K, Pham J, Kim K, He Z, Sontheimer E, et al. (2004).
4161:. If this is an intentional citation to a retracted paper, please replace
3594:"The contributions of dsRNA structure to Dicer specificity and efficiency"
3174:
13294:
13214:
12043:
11915:. Handbook of Experimental Pharmacology. Vol. 173. pp. 97–104.
11039:
10244:
9678:
9102:
8535:
8486:
8437:
8388:
8339:
7253:
7071:
7053:
6141:
5233:
Schwarz DS, Hutvágner G, Du T, Xu Z, Aronin N, Zamore PD (October 2003).
3711:
2997:
2961:
2890:
2613:
2600:
2593:
2531:
2394:
2390:
2349:
2341:
2224:
1503:
1283:
889:
732:
633:
518:
432:
64:
12949:
12196:
11635:
10841:
9260:
8584:
8034:
7571:
7518:
6954:
Makarova KS, Grishin NV, Shabalina SA, Wolf YI, Koonin EV (March 2006).
6280:
5584:
5567:
5491:
5399:
4729:
4674:
4623:
4468:
3960:
3659:
3609:
3535:
1222:; thus miRNA activity is particularly wide-ranging and regulates entire
13366:
13363:
13078:
10464:
8871:
3995:
Baulcombe DC (January 2007). "Molecular biology. Amplified silencing".
3044:
2927:
2882:
2835:
2816:
2783:
2625:
2607:
2458:. Studies in cells and in mouse have shown that specifically targeting
2317:
1541:
1453:
1449:
1398:
1365:
1235:
1026:
952:
or mammals. In plants, RNAi is thought to propagate by the transfer of
842:
541:
291:
144:
128:
121:
113:
25:
12013:
Applying genomic and proteomic microarray technology in drug discovery
10381:
9295:"Role of delta-aminolevulinic acid in the symptoms of acute porphyria"
8691:
8422:"DEQOR: a web-based tool for the design and quality control of siRNAs"
5727:
3763:
13383:
13233:
13178:
13075:, a collection of free articles about RNAi as a therapeutic strategy.
12706:
12354:
11764:"Mechanisms, Applications, and Challenges of Insect RNA Interference"
11138:
10872:
10227:
Kusov Y, Kanda T, Palmenberg A, Sgro JY, Gauss-Müller V (June 2006).
9590:
8842:
6332:
5677:
5566:
Lian S, Jakymiw A, Eystathioy T, Hamel J, Fritzler M, Chan E (2006).
3797:"TAF11 Assembles the RISC Loading Complex to Enhance RNAi Efficiency"
3477:
3040:
3036:
3032:
2878:
2869:
2865:
2550:
have produced tearless onions and RNAi has been used in BP1 genes in
2543:
2508:
2282:
1526:
1491:
1483:
1463:
1445:
1441:
1437:
1350:
1266:
1201:
893:
728:
690:
648:
The active components of an RNA-induced silencing complex (RISC) are
637:
615:
583:
412:
400:
335:
244:
229:
221:
217:
148:
140:
12761:
11846:
10823:
10229:"Silencing of hepatitis A virus infection by small interfering RNAs"
9890:
9629:
7660:"Interaction of viruses with the mammalian RNA interference pathway"
7284:
6432:
5620:
5536:
5203:
5065:
Gregory RI, Chendrimada TP, Cooch N, Shiekhattar R (November 2005).
4861:
Maffioletti E, Tardito D, Gennarelli M, Bocchio-Chiavetto L (2014).
3217:
Matranga C, Tomari Y, Shin C, Bartel DP, Zamore PD (November 2005).
1017:, further demonstrates that inducing two RNAi-related proteins from
13342:
13285:
13040:
12310:
Antisense nucleic acids and proteins: fundamentals and applications
12273:"Transgene-mediated suppression of chalcone synthase expression in
11244:
10794:
10690:
Lapteva N, Yang AG, Sanders DE, Strube RW, Chen SY (January 2005).
9942:"Aptamer-siRNA Chimeras: Discovery, Progress, and Future Prospects"
7712:
6042:
6025:
5374:
Ma JB, Yuan YR, Meister G, Pei Y, Tuschl T, Patel DJ (March 2005).
4652:
3058:
3025:
2787:
2551:
2523:
2512:
2427:
2309:
1239:
1139:
1131:
977:
920:
846:
783:
759:
743:
721:
713:
681:
500:
481:
360:
355:
342:
171:
101:
76:
21:
12629:
12270:
9244:"An update of clinical management of acute intermittent porphyria"
6824:"Evolution and diversification of RNA silencing proteins in fungi"
5064:
4367:
Qureshi A, Thakur N, Monga I, Thakur A, Kumar M (1 January 2014).
3636:"The promises and pitfalls of RNA-interference-based therapeutics"
1296:), is homologous to and originally evolved from components of the
770:
11594:
9416:"Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1"
8951:"Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1"
6065:
Sugiyama T, Cam H, Verdel A, Moazed D, Grewal SI (January 2005).
4207:
3696:"A computational study of off-target effects of RNA interference"
2898:
2861:
2619:
2555:
2530:
plants and fortification of plants such as tomatoes with dietary
2297:
2263:
1923:
Optic atrophy, non-arteritic anterior ischaemic optic neuropathy
1479:
infusion-related reactions and reduced vitamin A levels (serum).
1390:
897:
807:
619:
496:
462:
196:
186:
11482:
11021:
9614:"Knocking down disease: a progress report on siRNA therapeutics"
8783:"Cre-lox-regulated conditional RNA interference from transgenes"
8566:
5759:"RNAi-mediated targeting of heterochromatin by the RITS complex"
579:
459:
are processed by distinct Argonaute proteins and Dicer enzymes.
127:
The RNAi pathway is a naturally occurring process found in many
12375:
10750:"Delivery systems for siRNA drug development in cancer therapy"
10039:
8518:
Naito Y, Ui-Tei K, Nishikawa T, Takebe Y, Saigo K (July 2006).
8469:
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K (July 2004).
7103:
Palauqui JC, Elmayan T, Pollien JM, Vaucheret H (August 1997).
7102:
6577:
Humphreys DT, Westman BJ, Martin DI, Preiss T (November 2005).
5967:"Small dsRNAs induce transcriptional activation in human cells"
5476:"Uncoupling of RNAi from active translation in mammalian cells"
4279:. Methods in Molecular Biology. Vol. 342. pp. 33–47.
3005:
2911:
2894:
2527:
2500:
2305:
2286:
2267:
1897:
Age-related macular degeneration, choroidal neovascularization
1519:
1377:
1373:
1372:
that reacts nonspecifically to foreign genetic material. Mouse
1185:
877:
803:
724:
652:
called Argonaute proteins, which cleave the target mRNA strand
416:
387:. A miRNA is expressed from a much longer RNA-coding gene as a
364:
143:
into short double-stranded fragments of approximately 21 to 23
13073:
web focus: "The development of RNAi as a therapeutic strategy"
11534:"Dissecting systemic RNA interference in the red flour beetle
11273:
11095:
8721:
4965:"MicroRNA and Posttranscriptional Dysregulation in Psychiatry"
4760:
3591:
2901:, researchers introduced additional copies of a gene encoding
1357:
that are automatically checked for possible cross-reactivity.
1353:
for the design of general mammal-specific, and virus-specific
1278:
that may also have played other cellular roles. A large-scale
1005:. The presence of RNAi in other budding yeast species such as
664:. However, only one of the two strands, which is known as the
8287:
Voorhoeve PM, Agami R (January 2003). "Knockdown stands up".
8066:"Plant microRNA: a small regulatory molecule with big impact"
4415:
4274:
2730:
2676:
2654:
2547:
2406:
1564:
1474:. To achieve therapeutic response, patisiran is encased by a
1431:
Timeline of the use of RNAi in medicine between 1996 and 2017
1318:
1231:
1204:. The role of endogenously expressed miRNA in downregulating
1112:
993:
928:
775:
595:
521:
altered and effective in down regulating DNA repair enzymes.
420:
201:
191:
132:
117:
11954:"Functional genomics using high-throughput RNA interference"
11953:
9413:
8948:
8780:
8321:
6953:
6706:
Aravind L, Watanabe H, Lipman DJ, Koonin EV (October 2000).
6576:
5137:
4094:
3072:
2522:
Development efforts have successfully reduced the levels of
12271:
Van Blokland R, Van der Geest N, Mol JN, Kooter JM (1994).
11022:
Boudreau RL, Rodríguez-Lebrón E, Davidson BL (April 2011).
9660:
8010:
6764:
6705:
6635:
5649:
5322:
5138:
Leuschner PJ, Ameres SL, Kueng S, Martinez J (March 2006).
4601:
3990:
3988:
3455:
2743:
2665:
2572:
2410:
1972:
Delayed graft function, complications of kidney transplant
1452:(2020 in Europe with anticipated US approval in 2021), and
932:
43:
molecules are involved in sequence-specific suppression of
12916:
11832:
10780:
9568:
8722:
Tiscornia G, Tergaonkar V, Galimi F, Verma IM (May 2004).
8517:
8468:
8370:
6314:
6123:
5921:
5565:
5108:
4315:
3108:"RNA interference: concept to reality in crop improvement"
13153:
12735:
12684:
12434:
12332:
11531:
11091:
11089:
11087:
9844:"Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine"
8419:
8237:
8104:
7549:
7287:"A pathogen-inducible endogenous siRNA in plant immunity"
6821:
6471:"Anti-viral RNA silencing: do we look like plants ?"
6263:
Luciano DJ, Mirsky H, Vendetti NJ, Maas S (August 2004).
6262:
5813:
4555:"Most mammalian mRNAs are conserved targets of microRNAs"
4450:
2938:
2386:
2382:
1436:
approved by regulatory authorities in the US and Europe:
170:. The pathway is also used as a practical tool for food,
40:
12740:, Kay MA (July 2002). "RNA interference in adult mice".
12510:
11085:
11083:
11081:
11079:
11077:
11075:
11073:
11071:
11069:
11067:
11024:"RNAi medicine for the brain: progresses and challenges"
10689:
10524:
Qureshi A, Thakur N, Monga I, Thakur A, Kumar M (2014).
10523:
10226:
10081:"Tapping RNA silencing pathways for plant biotechnology"
9990:
8995:
8901:
8656:
7741:
7235:
4366:
3985:
3216:
668:, binds Argonaute and directs gene silencing. The other
560:
during which the Dicer-produced initiating or 'primary'
306:
during which the Dicer-produced initiating or 'primary'
11189:
10613:
10367:
10119:
9757:. Advances in Genetics. Vol. 88. pp. 71–110.
9192:
8008:
6064:
5756:
5606:
5274:
Preall JB, He Z, Gorra JM, Sontheimer EJ (March 2006).
5273:
4552:
3558:
Zamore PD, Tuschl T, Sharp PA, Bartel DP (March 2000).
3557:
1325:
200:, which catalyzes the cleavage of dsRNA to siRNAs. The
12603:
12178:
11098:
Annual Review of Chemical and Biomolecular Engineering
10445:
10402:
9893:"A Highly Durable RNAi Therapeutic Inhibitor of PCSK9"
9343:"LABEL:GIVLAARI- givosiran sodium injection, solution"
9292:
9072:"Drug Approval Package: GIVLAARI (givosiran)Injection"
8148:
Zhang B, Pan X, Cobb GP, Anderson TA (February 2007).
6519:
6224:"Double-stranded RNA as a template for gene silencing"
5235:"Asymmetry in the assembly of the RNAi enzyme complex"
3105:
2225:
Legal categorization and legal issues in a near future
1546:
transthyretin mediated amyloidosis with polyneuropathy
13127:
11910:
11410:
11408:
11230:
11064:
10962:
9088:
8064:
Zhang B, Pan X, Cobb GP, Anderson TA (January 2006).
7343:
6175:"RNA editing by adenosine deaminases that act on RNA"
6023:
5185:
5183:
4703:
1423:
fly, a common model organism used in RNAi experiments
892:
that is most prevalent in higher eukaryotes converts
11686:
11328:
International Journal of Food Sciences and Nutrition
10921:
9564:
9562:
9054:"LABEL:ONPATTRO- patisiran injection, lipid complex"
8188:
8147:
8063:
5232:
3054:
12557:"A brief history of RNAi: the silence of the genes"
12511:Pal-Bhadra M, Bhadra U, Birchler JA (August 1997).
11878:
Biochemical and Biophysical Research Communications
11414:
8616:Stein P, Zeng F, Pan H, Schultz RM (October 2005).
8615:
8238:Anantharaman V, Koonin EV, Aravind L (April 2002).
7915:"Role of microRNAs in plant and animal development"
6894:
5864:
2786:water. The molecules are absorbed into the plants'
12264:
12010:
11757:
11755:
11753:
11532:Miller SC, Miyata K, Brown SJ, Tomoyasu Y (2012).
11405:
10126:British Industrial Biological Research Association
7799:Li Y, Lu J, Han Y, Fan X, Ding SW (October 2013).
5180:
5110:
4809:
4553:Friedman RC, Farh KK, Burge CB, Bartel DP (2009).
4499:
3794:
3156:
2352:as well as other cardiometabolic diseases such as
1570:Investigational RNAi therapeutics in development:
1308:
1200:or incompletely differentiated cell types such as
10648:
9559:
9293:Bissell DM, Lai JC, Meister RK, Blanc PD (2015).
9150:Puy H, Gouya L, Deybach JC (2010). "Porphyrias".
8420:Henschel A, Buchholz F, Habermann B (July 2004).
7967:
6822:Nakayashiki H, Kadotani N, Mayama S (July 2006).
6363:
5964:
3313:
2747:s each. This has led to identification of future
2477:
2454:RNAi strategies also show potential for treating
786:. These processed RNAs are incorporated into the
239:Exogenous dsRNA initiates RNAi by activating the
13421:
12920:, Zuckerman JE, Choi CH, Seligson D, Tolcher A,
12661:"The Nobel Prize in Physiology or Medicine 2006"
12048:. Cambridge University Press. pp. ix–xiii.
9939:
9611:
9241:
7912:
7600:
7386:
6670:
5373:
5013:
4451:Okamura K, Ishizuka A, Siomi H, Siomi M (2004).
3942:
3402:
3106:Saurabh S, Vidyarthi AS, Prasad D (March 2014).
2923:, but the molecular mechanism remained unknown.
1176:organization triggers to mediate viral latency.
528:
131:and animal cells. It is initiated by the enzyme
124:) and also influences development of organisms.
13059:2 American ‘Worm People’ Win Nobel for RNA Work
12307:
12179:Napoli C, Lemieux C, Jorgensen R (April 1990).
11750:
9149:
7968:Lee RC, Feinbaum RL, Ambros V (December 1993).
7744:"Antiviral RNA interference in mammalian cells"
7435:
7278:
6468:
5713:
4309:
3633:
2293:also worked to bring RNAi therapies to market.
13094:Pre-designed and custom RNA Interference tools
12428:
11951:
11538:: parameters affecting the efficiency of RNAi"
10922:Raoul C, Barker SD, Aebischer P (March 2006).
10649:Cioca DP, Aoki Y, Kiyosawa K (February 2003).
9803:
9752:
9506:
9397:"LABEL: OXLUMO- lumasiran injection, solution"
8286:
8150:"microRNAs as oncogenes and tumor suppressors"
7187:Lucy AP, Guo HS, Li WX, Ding SW (April 2000).
7004:
6520:Jones L, Ratcliff F, Baulcombe DC (May 2001).
6408:
5707:
5430:
4360:
4239:
3378:The Nobel Prize in Physiology or Medicine 2006
3367:
3365:
3363:
3361:
2803:for a defined set of experimental conditions.
2050:Diabetic macular oedema, macular degeneration
1184:Endogenously expressed miRNAs, including both
1138:in response to infection by specific types of
1044:
568:are structurally distinct from Dicer-produced
463:Three prime untranslated regions and microRNAs
314:are structurally distinct from Dicer-produced
13113:
12369:
11692:
10324:
8838:
8836:
8609:
8280:
8231:
8098:
8002:
7186:
6664:
4962:
3895:Roberts TC (2015). "The microRNA Machinery".
3264:
3031:The FDA approved the first siRNA-based drug (
2413:) on host cells can prevent HIV viral entry.
1393:encoding the appropriate sequence from which
1282:study likewise indicates that the eukaryotic
883:
12736:McCaffrey AP, Meuse L, Pham TT, Conklin DS,
12227:
12172:
12068:
11368:
11325:
8650:
8511:
8141:
8011:"Control of leaf morphogenesis by microRNAs"
7657:
7492:
6895:Morita T, Mochizuki Y, Aiba H (March 2006).
6629:
6256:
4956:
4905:
4854:
4803:
4754:
4595:
3741:
3739:
3693:
3157:Weiss B, Davidkova G, Zhou LW (March 1999).
2546:. Silencing lachrymatory factor synthase in
1544:for the treatment of adults with hereditary
1157:. A similar role in immunity may operate in
939:
765:
727:(an atom with two positive charges) such as
247:with a 2-nucleotide overhang at the 3′ end.
13008:Cambridge University's The Naked Scientists
12504:
12469:
12326:
12113:
11485:"Environmental RNAi in herbivorous insects"
11132:
10743:
10741:
10739:
10737:
10735:
10733:
10731:
10729:
10727:
10496:
10275:
10185:
10078:
9822:
9605:
8189:Cerutti H, Casas-Mollano JA (August 2006).
8057:
7007:"Inhibition of viruses by RNA interference"
6888:
6815:
6310:
6308:
5643:
5189:
4706:"The impact of microRNAs on protein output"
4548:
4546:
4409:
4183:
3396:
3358:
3008:. By 2006, the first applications to reach
2893:in the early 1990s. In an attempt to alter
814:formation serves to downregulate genes pre-
13120:
13106:
12800:"siRNA-based approaches in cancer therapy"
12119:
11693:Mongelli V, Saleh MC (29 September 2016).
11183:
8833:
8715:
7906:
7798:
7387:Zambon RA, Vakharia VN, Wu LP (May 2006).
6998:
5915:
5858:
5117:(5th ed.). WH Freeman: New York, NY.
4911:
4816:World Journal of Gastrointestinal Oncology
4175:|...|intentional=yes}}
3513:
3212:
3210:
1179:
158:RNAi is a valuable research tool, both in
12957:
12815:
12572:
12528:
12487:
12411:
12401:
12292:
12277:results from an increase in RNA turnover"
12204:
12155:
12145:
12096:
12086:
12041:
12035:
12008:
11977:
11945:
11875:
11801:
11669:
11612:
11571:
11561:
11508:
11443:
11224:
11207:
11166:
11156:
11047:
10998:
10988:
10939:
10898:
10849:
10765:
10707:
10666:
10590:
10549:
10473:
10463:
10293:
10252:
10203:
10161:Current Opinion in Molecular Therapeutics
10096:
10008:
9967:
9957:
9916:
9867:
9780:
9686:
9637:
9612:Wittrup A, Lieberman J (September 2015).
9542:
9524:
9431:
9318:
9269:
9259:
9218:
9021:
8870:
8860:
8816:
8806:
8757:
8747:
8690:
8633:
8592:
8560:
8543:
8494:
8462:
8445:
8413:
8396:
8364:
8347:
8263:
8214:
8165:
8081:
7985:
7889:
7832:
7775:
7675:
7634:
7526:
7469:
7404:
7320:
7310:
7261:
7212:
7128:
7079:
7030:
6981:
6971:
6930:
6920:
6798:
6741:
6731:
6612:
6602:
6570:
6545:
6496:
6486:
6464:
6462:
6460:
6440:
6414:
6391:
6381:
6357:
6340:
6321:Nature Structural & Molecular Biology
6288:
6239:
6215:
6198:
6166:
6149:
6117:
6100:
6090:
6041:
6000:
5990:
5890:
5790:
5583:
5568:"GW bodies, microRNAs and the cell cycle"
5499:
5407:
5299:
5250:
5192:Nature Structural & Molecular Biology
5163:
5131:
5104:
5102:
5082:
4990:
4980:
4939:
4929:
4888:
4878:
4837:
4827:
4786:
4737:
4578:
4517:
4476:
4392:
4215:
3994:
3968:
3938:
3936:
3934:
3932:
3820:
3771:
3745:
3736:
3719:
3667:
3617:
3575:
3416:
3290:
3234:
3182:
3133:
2822:
2102:Ocular hypertension, open-angle glaucoma
1397:can be transcribed, or by more elaborate
564:are used as templates. These 'secondary'
310:are used as templates. These 'secondary'
12658:
11826:
11761:
11110:10.1146/annurev-chembioeng-061010-114133
10754:Asian Journal of Pharmaceutical Sciences
10724:
10276:Jia F, Zhang YZ, Liu CM (October 2006).
10158:
9462:
8774:
8182:
8119:10.1146/annurev.arplant.57.032905.105218
7961:
7594:
7096:
6947:
6305:
6191:10.1146/annurev.biochem.71.110601.135501
6058:
4543:
4090:
4088:
3843:
3449:
3374:"Advanced Information: RNA interference"
2855:
2449:
1426:
1412:
1153:and is active against pathogens such as
914:
769:
606:
578:
433:http://crdd.osdd.net/servers/virmirna/).
329:
185:
20:
12838:
12554:
12550:
12548:
12221:
12062:
12002:
11904:
9709:
7543:
7151:
7145:
7047:
6699:
5600:
5522:
5516:
5473:
5058:
5007:
4444:
4040:
3894:
3634:Castanotto D, Rossi JJ (January 2009).
3260:
3258:
3256:
3254:
3207:
2304:, developed by a collaboration between
1741:Respiratory syncytial virus infections
1061:
935:complex, which mediates gene silencing.
876:mating-type regions and centromeres to
751:into a cleavage-favorable RISC region.
13422:
12071:"Planting the Seeds of a New Paradigm"
11952:Vanhecke D, Janitz M (February 2005).
11720:10.1146/annurev-virology-110615-042447
11601:Regulatory Toxicology and Pharmacology
11371:Applied Biochemistry and Biotechnology
10747:
10441:
10439:
10437:
10435:
9483:"Amvuttra | European Medicines Agency"
7855:
7698:
7692:
7651:
7380:
6673:Molecular and Biochemical Parasitology
6638:Molecular and Biochemical Parasitology
6457:
5807:
5750:
5316:
5267:
5099:
4192:"The functions of microRNAs in plants"
4189:
4036:
4034:
3929:
3689:
3687:
2794:
2329:atherosclerotic cardiovascular disease
2256:
2233:
265:cooperates with AGO to form the RISC.
13101:
12881:
12597:
10572:
9841:
7913:Carrington JC, Ambros V (July 2003).
7337:
7229:
6421:Nature Reviews Molecular Cell Biology
4810:Bernstein C, Bernstein H (May 2015).
4268:
4085:
3307:
2982:Nobel Prize in Physiology or Medicine
2827:Genome-scale RNAi research relies on
1709:VP24, VP35, Zaire Ebola L-polymerase
820:RNA-induced transcriptional silencing
705:of an RNA-bound Argonaute. Here, the
181:
73:Nobel Prize in Physiology or Medicine
16:Biological process of gene regulation
12797:
12545:
12463:
10186:Jiang M, Milner J (September 2002).
7429:
7180:
6221:
6172:
6017:
5559:
4963:Geaghan M, Cairns MJ (August 2015).
3752:Wiley Interdisciplinary Reviews: RNA
3371:
3251:
3163:Cellular and Molecular Life Sciences
2987:
2933:post transcriptional gene silencing.
2762:
1326:Off-Target Effects of Gene Knockdown
1238:. Here, miRNAs can function as both
1065:
11869:
11762:Zhu KY, Palli SR (7 January 2020).
10432:
8955:The New England Journal of Medicine
7849:
7658:Schütz S, Sarnow P (January 2006).
7601:Berkhout B, Haasnoot J (May 2006).
6370:The Journal of Biological Chemistry
4493:
4031:
3943:Parker G, Eckert D, Bass B (2006).
3684:
2180:Transthyretin-mediated amyloidosis
1949:Kidney injury, acute renal failure
1819:Transthyretin-mediated amyloidosis
845:formation, causing slow or stalled
826:this complex contains Argonaute, a
778:trims double stranded RNA, to form
57:post-transcriptional gene silencing
39:) is a biological process in which
13:
12294:10.1046/j.1365-313X.1994.6060861.x
12242:10.1111/j.1365-2958.1992.tb02202.x
12120:Ecker JR, Davis RW (August 1986).
11786:10.1146/annurev-ento-011019-025224
11428:American Phytopathological Society
9763:10.1016/B978-0-12-800148-6.00004-3
7486:
7005:Stram Y, Kuzntzova L (June 2006).
6265:"RNA editing of a miRNA precursor"
5958:
5467:
5367:
4867:Frontiers in Cellular Neuroscience
2375:
1540:In 2022, the FDA and EMA approved
1482:In 2019, the FDA and EMA approved
709:5′ end of the RNA strand enters a
485:inhibit the expression of a mRNA.
14:
13456:
13027: – A 15-minute video of the
12996:
10748:Xu CF, Wang J (1 February 2015).
5650:Hammond S, Bernstein E, Beach D,
2921:co-suppression of gene expression
2851:
1486:for the treatment of adults with
1149:, RNAi is important in antiviral
818:; this process is referred to as
490:microRNA response elements (MREs)
385:post-transcriptional modification
268:After integration into the RISC,
12974:
12910:
12875:
12832:
12791:
12783:
12729:
12678:
12652:
12308:Mol JN, van der Krol AR (1991).
12301:
11629:
11588:
11525:
11476:
11362:
11319:
11267:
11209:10.1111/j.1467-7652.2005.00175.x
11015:
10956:
10915:
10866:
10817:
10774:
10683:
10642:
10607:
10592:10.1097/00002030-200317004-00014
10566:
10517:
10490:
10396:
10361:
10318:
10269:
10220:
10179:
10152:
10113:
10098:10.1111/j.1467-7652.2010.00505.x
10072:
10033:
9984:
9933:
9884:
9835:
9823:Eric Bender (1 September 2014).
9816:
9804:John LaMattina (15 April 2014).
9797:
9746:
9703:
9654:
9500:
9475:
9465:"Drug Trial Snapshots: AMVUTTRA"
9463:Research Cf (27 November 2023).
9456:
9407:
9389:
9371:
9353:
9335:
9299:The American Journal of Medicine
9286:
9248:Application of Clinical Genetics
9235:
9186:
9143:
9125:
9082:
9064:
9046:
8989:
8942:
8895:
8328:Molecular Therapy: Nucleic Acids
8315:
7858:"Antiviral silencing in animals"
7406:10.1111/j.1462-5822.2006.00688.x
6650:10.1016/j.molbiopara.2003.10.005
5699:
5445:10.1111/j.1432-0436.2005.00029.x
3694:Qiu S, Adema CM, Lane T (2005).
3499:
3071:
3057:
2592:RNAi is under development as an
2538:have also been used to decrease
2507:but naturally contain the toxic
2363:
2251:partial sequence complementarity
2125:Escherichia coli-carrying shRNA
1070:
594:(NPC) into the cytoplasm, where
572:and appear to be produced by an
474:Three prime untranslated regions
318:and appear to be produced by an
12470:Guo S, Kemphues KJ (May 1995).
9997:New England Journal of Medicine
9940:Kruspe S, Giangrande P (2017).
9897:New England Journal of Medicine
9848:New England Journal of Medicine
9420:New England Journal of Medicine
9361:"Drug Approval Package: OXLUMO"
9242:Pischik E, Kauppinen R (2015).
9091:New England Journal of Medicine
8908:New England Journal of Medicine
8849:New England Journal of Medicine
7856:Li HW, Ding SW (October 2005).
7792:
7735:
6758:
6513:
6469:Saumet A, Lecellier CH (2006).
5716:Cytogenetic and Genome Research
5424:
5226:
4779:10.1590/S1415-47572011000300001
4697:
4646:
4534:
3888:
3837:
3788:
3265:Kupferschmidt K (August 2013).
2587:
2246:nanoparticle encapsulated siRNA
2128:Familial adenomatous polyposis
1880:Pachyonychia Congenita Project
1309:RNAi pathway for gene knockdown
1303:
469:Three prime untranslated region
12312:. M. Dekker. pp. 4, 136.
11979:11858/00-001M-0000-0010-86E7-8
11662:10.1016/j.jinsphys.2010.11.006
10891:10.1523/jneurosci.3637-10.2010
8107:Annual Review of Plant Biology
6831:Journal of Molecular Evolution
6130:Molecular and Cellular Biology
4982:10.1016/j.biopsych.2014.12.009
4767:Genetics and Molecular Biology
4242:Trends in Biochemical Sciences
3746:Nakanishi K (September 2016).
3507:
3405:Journal of Molecular Histology
3150:
2840:single nucleotide polymorphism
2807:are frequently used to design
2478:Stimulation of immune response
2151:Self-delivering RNAi compound
2076:Ocular pain, dry-eye syndrome
1408:
411:. This complex consists of an
232:structure of pre-miRNA in the
212:process that is controlled by
75:for their work on RNAi in the
1:
13025:NOVA scienceNOW explains RNAi
13014:Animation of the RNAi process
12853:10.1016/s0140-6736(03)14637-5
12659:Daneholt B (2 October 2006).
12555:Sen GL, Blau HM (July 2006).
12530:10.1016/S0092-8674(00)80508-5
12449:10.1126/science.276.5318.1558
12069:Matzke MA, Matzke AJ (2004).
11970:10.1016/S1359-6446(04)03352-5
10058:10.1016/j.jbiotec.2005.11.001
9507:Guerriaud M, Kohli E (2022).
9164:10.1016/S0140-6736(09)61925-5
9014:10.1080/13506129.2022.2091985
8530:(Web Server issue): W448–50.
8432:(Web Server issue): W113–20.
8383:(Web Server issue): W589–91.
8301:10.1016/S0167-7799(02)00002-1
7882:10.1016/j.febslet.2005.08.034
7627:10.1016/j.febslet.2006.02.070
7166:10.1016/S0168-9525(01)02367-8
6685:10.1016/S0166-6851(03)00079-3
6547:10.1016/S0960-9822(01)00226-3
6415:Nishikura K (December 2006).
6241:10.1016/S0092-8674(02)71133-1
6179:Annual Review of Biochemistry
5252:10.1016/S0092-8674(03)00759-1
4519:10.1016/S0092-8674(04)00261-2
3577:10.1016/S0092-8674(00)80620-0
3092:
3087:DNA-directed RNA interference
2334:
2325:familial hypercholesterolemia
1111:to viruses and other foreign
788:RNA-induced silencing complex
720:and makes contacts through a
529:RISC activation and catalysis
153:RNA-induced silencing complex
13323:CRISPR genome-editing method
13003:Overview of the RNAi process
12924:, et al. (April 2010).
12489:10.1016/0092-8674(95)90082-9
12088:10.1371/journal.pbio.0020133
11642:Journal of Insect Physiology
11563:10.1371/journal.pone.0047431
11436:10.1094/phyto-07-20-0280-rvw
11340:10.3109/09637486.2012.713918
10452:Journal of Clinical Medicine
9311:10.1016/j.amjmed.2014.10.026
8481:(Web Server issue): W124–9.
7987:10.1016/0092-8674(93)90529-Y
3813:10.1016/j.molcel.2015.07.006
3292:10.1126/science.341.6147.732
3022:nanoparticle delivery system
1992:RTP801 (Proprietary target)
1531:primary hyperoxaluria type 1
1508:aminolevulinic acid synthase
1490:(AHP). The FDA also granted
1276:RNA-dependent RNA polymerase
1249:
1107:RNAi is a vital part of the
810:and associated induction of
574:RNA-dependent RNA polymerase
419:and a dsRNA-binding protein
320:RNA-dependent RNA polymerase
7:
11769:Annual Review of Entomology
11614:10.1016/j.yrtph.2016.07.009
11196:Plant Biotechnology Journal
10879:The Journal of Neuroscience
10085:Plant Biotechnology Journal
9959:10.3390/biomedicines5030045
9825:"The Second Coming of RNAi"
8635:10.1016/j.ydbio.2005.08.015
8167:10.1016/j.ydbio.2006.08.028
8083:10.1016/j.ydbio.2005.10.036
7677:10.1016/j.virol.2005.09.034
4190:Wang QL, Li ZH (May 2007).
3905:10.1007/978-3-319-22380-3_2
3050:
3018:respiratory syncytial virus
2868:; the right plants contain
1472:hereditary ATTR amyloidosis
1376:and cells from early mouse
1345:that about 10% of possible
1263:most recent common ancestor
1102:
1045:Related prokaryotic systems
395:which is processed, in the
325:
276:template. Differently from
10:
13461:
13397:James Webb Space Telescope
12798:Devi GR (September 2006).
11890:10.1016/j.bbrc.2005.08.147
10767:10.1016/j.ajps.2014.08.011
10616:Current Molecular Medicine
10079:Frizzi A, Huang S (2010).
5084:10.1016/j.cell.2005.10.022
4254:10.1016/j.tibs.2007.02.006
3236:10.1016/j.cell.2005.08.044
2905:, a key enzyme for flower
2846:
2805:Artificial neural networks
2777:
2456:neurodegenerative diseases
2277:The first approved use of
1646:MD Anderson Cancer Center
884:Crosstalk with RNA editing
488:The 3′-UTR often contains
466:
353:
13377:developed at record speed
13138:
13132:Breakthroughs of the Year
12896:10.1016/j.lfs.2006.06.011
11703:Annual Review of Virology
11383:10.1007/s12010-012-0046-5
11297:10.1007/s00425-018-2875-0
10406:Nucleic Acid Therapeutics
10295:10.1007/s10529-006-9138-z
10138:10.1016/j.fct.2010.04.017
9724:10.1007/s11095-006-9180-5
9526:10.3389/fmed.2022.1012497
9383:European Medicines Agency
9211:10.1007/s40271-018-0319-3
9137:European Medicines Agency
8207:10.1007/s00294-006-0078-x
7023:10.1007/s11262-005-6914-0
6851:10.1007/s00239-005-0257-2
5301:10.1016/j.cub.2006.01.061
4912:Mellios N, Sur M (2012).
4430:10.1016/j.tcb.2006.12.007
3427:10.1007/s10735-004-2192-8
3135:10.1007/s00425-013-2019-5
3012:were in the treatment of
2829:high-throughput screening
2603:(butterflies and moths).
2416:
2348:(PH) and hereditary ATTR
2200:Conserved regions of HBV
2154:Cicatrix scar prevention
1557:Arrowhead Pharmaceuticals
1385:, for example, by stable
1234:and dysregulation of the
1079:This section needs to be
940:Variation among organisms
900:in dsRNAs via the enzyme
766:Transcriptional silencing
208:RNAi is an RNA-dependent
13033:broadcast that aired on
11028:Human Molecular Genetics
10628:10.2174/1566524043360492
10046:Journal of Biotechnology
7358:10.1126/stke.3392006pe27
7121:10.1093/emboj/16.15.4738
5156:10.1038/sj.embor.7400637
4931:10.3389/fpsyt.2012.00039
4880:10.3389/fncel.2014.00075
4285:10.1385/1-59745-123-1:33
2189:Alnylam Pharmaceuticals
1854:Calando Pharmaceuticals
1828:Alnylam Pharmaceuticals
1802:Alnylam Pharmaceuticals
1750:Alnylam Pharmaceuticals
1620:Alnylam Pharmaceuticals
1317:cascade begins once the
1002:Saccharomyces cerevisiae
931:and integrated into the
640:protein in complex with
499:web site, an archive of
13252:Human genetic variation
13187:Whole genome sequencing
12147:10.1073/pnas.83.15.5372
11921:10.1007/3-540-27262-3_5
11158:10.1073/pnas.0605389103
10990:10.1073/pnas.0501507102
10542:10.1093/database/bau103
10339:10.1637/7365-041205R2.1
9618:Nature Reviews Genetics
8808:10.1073/pnas.0403954101
8749:10.1073/pnas.0402107101
8683:10.1126/science.1068999
8289:Trends in Biotechnology
7939:10.1126/science.1085242
7825:10.1126/science.1241911
7768:10.1126/science.1241930
7462:10.1126/science.1125694
7312:10.1073/pnas.0608258103
7205:10.1093/emboj/19.7.1672
6922:10.1073/pnas.0509638103
6791:10.1126/science.1176945
6767:"RNAi in budding yeast"
6604:10.1073/pnas.0506482102
6092:10.1073/pnas.0407641102
5992:10.1073/pnas.0607015103
5936:10.1023/A:1022815931524
5892:10.1126/science.1074973
5836:10.1126/science.1128813
5783:10.1126/science.1093686
5345:10.1126/science.1102755
5036:10.1126/science.1088710
4918:Frontiers in Psychiatry
4385:10.1093/database/bau103
4338:10.1126/science.1096781
4196:Frontiers in Bioscience
4144:10.1126/science.abf4837
4117:10.1126/science.1136699
4063:10.1126/science.1132839
4009:10.1126/science.1138030
3897:MicroRNA: Basic Science
3866:10.1126/science.1069132
3336:10.1126/science.1121638
2759:of other insecticides.
2749:insecticide development
2517:delta-cadinene synthase
2494:
2432:chemotherapeutic agents
2177:siRNA–GalNAc conjugate
1871:Pachyonychia congenita
1776:Tekmira Pharmaceutical
1724:Tekmira Pharmaceutical
1698:Tekmira Pharmaceutical
1561:Alnylam Pharmaceuticals
1488:acute hepatic porphyria
1468:Alnylam Pharmaceuticals
1208:was first described in
1196:and the maintenance of
1180:Downregulation of genes
1121:express multiple Dicer
1008:Saccharomyces castellii
13356:Single-cell sequencing
13260:Cellular reprogramming
13046:10 August 2019 at the
12817:10.1038/sj.cgt.7700931
12403:10.1073/pnas.92.5.1679
12230:Molecular Microbiology
11501:10.1261/rna.048116.114
10709:10.1038/sj.cgt.7700770
10668:10.1038/sj.cgt.7700544
10205:10.1038/sj.onc.1205878
9667:Nucleic Acids Research
9097:(28–4793): 2366–2367.
8524:Nucleic Acids Research
8475:Nucleic Acids Research
8426:Nucleic Acids Research
8377:Nucleic Acids Research
8244:Nucleic Acids Research
7060:Nucleic Acids Research
6733:10.1073/pnas.200346997
6383:10.1074/jbc.M407876200
6222:Bass BL (April 2000).
5474:Gu S, Rossi J (2005).
5113:Molecular Cell Biology
3700:Nucleic Acids Research
3267:"A lethal dose of RNA"
2952:Caenorhabditis elegans
2926:Not long after, plant
2873:
2823:Genome-scale screening
2757:insecticide resistance
2007:Quark Pharmaceuticals
1981:Quark Pharmaceuticals
1958:Quark Pharmaceuticals
1932:Quark Pharmaceuticals
1793:Hypercholesterolaemia
1767:Hypercholesterolaemia
1715:Ebola-virus infection
1432:
1424:
1298:translation initiation
956:between cells through
936:
799:
790:(RISC), which targets
645:
604:
588:microprocessor complex
409:microprocessor complex
375:, particularly during
351:
205:
89:for gene suppression.
82:Caenorhabditis elegans
29:
13171:Accelerating universe
12574:10.1096/fj.06-6014rev
12017:. CRC Press. p.
10941:10.1038/sj.gt.3302690
10418:10.1089/nat.2012.0359
10282:Biotechnology Letters
10010:10.1056/NEJMoa1913147
9909:10.1056/NEJMoa1609243
9860:10.1056/NEJMoa2035389
9513:Frontiers in Medicine
9433:10.1056/NEJMoa2021712
9023:1959.4/unsworks_80922
8967:10.1056/NEJMoa2021712
8920:10.1056/NEJMoa1913147
8862:10.1056/NEJMoa1716153
8622:Developmental Biology
8256:10.1093/nar/30.7.1427
8154:Developmental Biology
8070:Developmental Biology
7393:Cellular Microbiology
6973:10.1186/1745-6150-1-7
6488:10.1186/1742-4690-3-3
4969:Biological Psychiatry
4829:10.4251/wjgo.v7.i5.30
4571:10.1101/gr.082701.108
4167:|...}}
4138:(Retracted, see
3175:10.1007/s000180050296
2994:small interfering RNA
2859:
2564:hexaploid bread races
2472:Polyglutamine disease
2450:Neurological diseases
2346:primary hyperoxaluria
1989:PF-655 (PF-04523655)
1865:K6a (N171K mutation)
1672:Silence Therapeutics
1535:hydroxyacid oxidase 1
1430:
1416:
1332:computational biology
1330:Extensive efforts in
1220:transcription factors
925:small interfering RNA
918:
780:small interfering RNA
773:
699:X-ray crystallography
610:
582:
549:to the RISC complex.
399:, to a 70-nucleotide
333:
189:
135:, which cleaves long
106:small interfering RNA
24:
13304:Cancer immunotherapy
13269:Ardipithecus ramidus
13090:19 June 2018 at the
11958:Drug Discovery Today
11913:RNA Towards Medicine
11835:Nature Biotechnology
11233:Nature Biotechnology
10245:10.1128/jvi.01773-05
9103:10.1056/NEJMe2010986
8340:10.1038/mtna.2016.66
7254:10.1128/JVI.01963-05
6142:10.1128/MCB.02189-05
3014:macular degeneration
2644:Helicoverpa armigera
2562:an investigation of
2534:. RNAi silencing of
2320:was a treatment for
2163:RXi Pharmaceuticals
1496:breakthrough therapy
1368:response, a form of
1280:comparative genomics
1118:Arabidopsis thaliana
1062:Biological functions
1021:facilitates RNAi in
592:nuclear pore complex
13347:neutron star merger
13335:gravitational waves
13243:Poincaré conjecture
12988:. 11 December 2020.
12950:10.1038/nature08956
12942:2010Natur.464.1067D
12804:Cancer Gene Therapy
12754:2002Natur.418...38M
12699:2001Natur.411..494E
12622:1998Natur.391..806F
12394:1995PNAS...92.1679K
12347:1997Natur.385..781C
12197:10.1105/tpc.2.4.279
12138:1986PNAS...83.5372E
11654:2011JInsP..57..231T
11554:2012PLoSO...747431M
11536:Tribolium castaneum
11430:: PHYTO–07–20–028.
11289:2018Plant.247.1465G
10981:2005PNAS..102.5820H
10842:10.1038/mt.2009.123
10783:Nature Neuroscience
10696:Cancer Gene Therapy
10655:Cancer Gene Therapy
10585:(Suppl 4): S103–5.
10370:Future Microbiology
10233:Journal of Virology
9583:2013NatMa..12..967K
9261:10.2147/TACG.S48605
8799:2004PNAS..10110380V
8740:2004PNAS..101.7347T
8675:2002Sci...296..550B
8585:10.1261/rna.2340906
8035:10.1038/nature01958
8027:2003Natur.425..257P
7931:2003Sci...301..336C
7874:2005FEBSL.579.5965L
7817:2013Sci...342..231L
7760:2013Sci...342..235M
7619:2006FEBSL.580.2896B
7572:10.1038/nature03957
7564:2005Natur.436.1044W
7519:10.1038/nature03870
7511:2005Natur.436.1040L
7505:(7053): 1040–1043.
7454:2006Sci...312..452W
7303:2006PNAS..10318002K
7242:Journal of Virology
6913:2006PNAS..103.4858M
6843:2006JMolE..63..127N
6783:2009Sci...326..544D
6724:2000PNAS...9711319A
6595:2005PNAS..10216961H
6538:2001CBio...11..747J
6281:10.1261/rna.7350304
6083:2005PNAS..102..152S
5983:2006PNAS..10317337L
5924:Chromosome Research
5883:2002Sci...297.1833V
5828:2006Sci...313.1134I
5775:2004Sci...303..672V
5670:2000Natur.404..293H
5585:10.4161/cc.5.3.2410
5492:10.1261/rna.7158605
5400:10.1038/nature03514
5392:2005Natur.434..666M
5337:2004Sci...306.1377T
5292:2006CBio...16..530P
5028:2003Sci...301.1921L
4730:10.1038/nature07242
4722:2008Natur.455...64B
4675:10.1038/nature07228
4667:2008Natur.455...58S
4624:10.1038/nature03315
4616:2005Natur.433..769L
4469:10.1101/gad.1210204
4330:2004Sci...304..734P
4109:2007Sci...315..244S
4055:2007Sci...315..241P
3961:10.1261/rna.2338706
3858:2002Sci...296.1270A
3660:10.1038/nature07758
3652:2009Natur.457..426C
3610:10.1261/rna.7272305
3536:10.1038/nature07754
3528:2009Natur.457..396S
3470:2001Natur.409..363B
3328:2006Sci...311..195M
3283:2013Sci...341..732K
3126:2014Plant.239..543S
2795:Functional genomics
2704:Acyrthosiphon pisum
2632:Tribolium castaneum
2560:functional genomics
2468:Parkinson's disease
2464:Alzheimer's disease
2279:lipid nanoparticles
2257:Lipid nanoparticles
2234:Delivery mechanisms
2215:Arrowhead Research
1512:aminolevulinic acid
1460:and eye disorders.
1052:CRISPR interference
996:, most notably the
902:adenosine deaminase
839:histone methylation
642:double-stranded RNA
625:Pyrococcus furiosus
403:structure called a
371:that help regulate
339:secondary structure
137:double-stranded RNA
96:Two types of small
49:double-stranded RNA
13445:Molecular genetics
13388:protein structures
12042:Zhang XHD (2011).
12009:Matson RS (2005).
11445:20.500.11937/83208
11040:10.1093/hmg/ddr137
10465:10.3390/jcm8010006
9679:10.1093/nar/gkz154
9403:. 2 December 2021.
8536:10.1093/nar/gkl214
8487:10.1093/nar/gkh442
8438:10.1093/nar/gkh408
8389:10.1093/nar/gki419
7154:Trends in Genetics
7072:10.1093/nar/gkl886
4277:MicroRNA Protocols
3712:10.1093/nar/gki324
3384:on 20 January 2007
2874:
2772:proof of principle
2741:have two or three
2672:Glossina morsitans
2638:Nilaparvata lugens
2540:Aspergillus flavus
2503:seeds are rich in
2421:While traditional
2356:and non-alcoholic
2291:Sirna Therapeutics
2024:Pancreatic cancer
1476:lipid nanoparticle
1433:
1425:
1155:Drosophila X virus
967:initiation factors
948:, although not in
937:
858:mating-type region
806:. Modification of
800:
646:
605:
429:Epstein–Barr virus
389:primary transcript
352:
206:
182:Cellular mechanism
30:
13415:
13414:
13375:COVID-19 vaccines
13331:First observation
13199:Molecular circuit
13071:Molecular Therapy
13041:Silencing Genomes
12936:(7291): 1067–70.
12693:(6836): 494–498.
12443:(5318): 1558–60.
12319:978-0-8247-8516-1
12055:978-0-521-73444-8
12028:978-0-8493-1469-8
11930:978-3-540-27261-8
10830:Molecular Therapy
10382:10.2217/fmb.14.94
10003:(24): 2289–2301.
9842:Baden LR (2021).
9772:978-0-12-800148-6
9487:www.ema.europa.eu
9426:(13): 1216–1226.
9158:(9718): 924–937.
8961:(13): 1216–1226.
8914:(24): 2289–2301.
7701:Nature Immunology
6777:(5952): 544–550.
5728:10.1159/000093326
5331:(5700): 1377–80.
5124:978-0-7167-4366-8
4294:978-1-59745-123-9
4003:(5809): 199–200.
3914:978-3-319-22379-7
3764:10.1002/wrna.1356
3522:(7228): 396–404.
2988:RNAi therapeutics
2949:to par-1 mRNA in
2916:Neurospora crassa
2903:chalcone synthase
2881:RNA expressed in
2813:genome annotation
2763:Transgenic plants
2751:targets, and the
2222:
2221:
1735:RSV nucleocapsid
1637:Advanced cancers
1628:siRNA–EphA2–DOPC
1502:designation, and
1244:tumor suppressors
1100:
1099:
989:Trypanosoma cruzi
896:nucleotides into
816:transcriptionally
670:anti-guide strand
618:protein from the
348:Brassica oleracea
116:sequences (e.g.,
100:(RNA) molecules,
87:antisense therapy
13452:
13430:RNA interference
13408:
13400:
13391:
13378:
13369:
13358:
13350:
13337:
13325:
13317:
13306:
13298:
13289:
13280:
13272:
13262:
13254:
13246:
13237:
13228:
13217:
13209:
13207:RNA interference
13201:
13189:
13181:
13173:
13165:
13157:
13122:
13115:
13108:
13099:
13098:
12990:
12989:
12978:
12972:
12971:
12961:
12914:
12908:
12907:
12879:
12873:
12872:
12847:(9393): 1401–3.
12836:
12830:
12829:
12819:
12795:
12789:
12788:
12787:
12781:
12733:
12727:
12726:
12707:10.1038/35078107
12682:
12676:
12675:
12673:
12671:
12656:
12650:
12649:
12616:(6669): 806–11.
12601:
12595:
12594:
12576:
12552:
12543:
12542:
12532:
12508:
12502:
12501:
12491:
12467:
12461:
12460:
12432:
12426:
12425:
12415:
12405:
12373:
12367:
12366:
12355:10.1038/385781a0
12330:
12324:
12323:
12305:
12299:
12298:
12296:
12268:
12262:
12261:
12225:
12219:
12218:
12208:
12176:
12170:
12169:
12159:
12149:
12117:
12111:
12110:
12100:
12090:
12066:
12060:
12059:
12039:
12033:
12032:
12016:
12006:
12000:
11999:
11981:
11949:
11943:
11942:
11908:
11902:
11901:
11873:
11867:
11866:
11830:
11824:
11823:
11805:
11759:
11748:
11747:
11699:
11690:
11684:
11683:
11673:
11633:
11627:
11626:
11616:
11592:
11586:
11585:
11575:
11565:
11529:
11523:
11522:
11512:
11480:
11474:
11473:
11447:
11412:
11403:
11402:
11366:
11360:
11359:
11323:
11317:
11316:
11283:(6): 1465–1473.
11271:
11265:
11264:
11228:
11222:
11221:
11211:
11187:
11181:
11180:
11170:
11160:
11136:
11130:
11129:
11093:
11062:
11061:
11051:
11019:
11013:
11012:
11002:
10992:
10960:
10954:
10953:
10943:
10919:
10913:
10912:
10902:
10885:(42): 13966–76.
10870:
10864:
10863:
10853:
10821:
10815:
10814:
10778:
10772:
10771:
10769:
10745:
10722:
10721:
10711:
10687:
10681:
10680:
10670:
10646:
10640:
10639:
10611:
10605:
10604:
10594:
10573:Crowe S (2003).
10570:
10564:
10563:
10553:
10521:
10515:
10514:
10494:
10488:
10487:
10477:
10467:
10443:
10430:
10429:
10400:
10394:
10393:
10365:
10359:
10358:
10322:
10316:
10315:
10297:
10273:
10267:
10266:
10256:
10239:(11): 5599–610.
10224:
10218:
10217:
10207:
10183:
10177:
10176:
10156:
10150:
10149:
10132:(7): 1773–1790.
10117:
10111:
10110:
10100:
10076:
10070:
10069:
10037:
10031:
10030:
10012:
9988:
9982:
9981:
9971:
9961:
9937:
9931:
9930:
9920:
9888:
9882:
9881:
9871:
9839:
9833:
9832:
9820:
9814:
9813:
9801:
9795:
9794:
9784:
9750:
9744:
9743:
9707:
9701:
9700:
9690:
9673:(8): 3957–3969.
9658:
9652:
9651:
9641:
9609:
9603:
9602:
9591:10.1038/nmat3765
9571:Nature Materials
9566:
9557:
9556:
9546:
9528:
9504:
9498:
9497:
9495:
9493:
9479:
9473:
9472:
9460:
9454:
9453:
9435:
9411:
9405:
9404:
9393:
9387:
9386:
9375:
9369:
9368:
9357:
9351:
9350:
9339:
9333:
9332:
9322:
9290:
9284:
9283:
9273:
9263:
9239:
9233:
9232:
9222:
9190:
9184:
9183:
9147:
9141:
9140:
9129:
9123:
9122:
9086:
9080:
9079:
9068:
9062:
9061:
9050:
9044:
9043:
9025:
8993:
8987:
8986:
8946:
8940:
8939:
8899:
8893:
8892:
8874:
8864:
8840:
8831:
8830:
8820:
8810:
8778:
8772:
8771:
8761:
8751:
8719:
8713:
8712:
8694:
8657:Brummelkamp TR,
8654:
8648:
8647:
8637:
8613:
8607:
8606:
8596:
8564:
8558:
8557:
8547:
8515:
8509:
8508:
8498:
8466:
8460:
8459:
8449:
8417:
8411:
8410:
8400:
8368:
8362:
8361:
8351:
8319:
8313:
8312:
8284:
8278:
8277:
8267:
8235:
8229:
8228:
8218:
8195:Current Genetics
8186:
8180:
8179:
8169:
8145:
8139:
8138:
8102:
8096:
8095:
8085:
8061:
8055:
8054:
8021:(6955): 257–63.
8006:
8000:
7999:
7989:
7965:
7959:
7958:
7910:
7904:
7903:
7893:
7853:
7847:
7846:
7836:
7796:
7790:
7789:
7779:
7739:
7733:
7732:
7696:
7690:
7689:
7679:
7655:
7649:
7648:
7638:
7613:(12): 2896–902.
7598:
7592:
7591:
7558:(7053): 1044–7.
7547:
7541:
7540:
7530:
7490:
7484:
7483:
7473:
7433:
7427:
7426:
7408:
7384:
7378:
7377:
7341:
7335:
7334:
7324:
7314:
7282:
7276:
7275:
7265:
7233:
7227:
7226:
7216:
7193:The EMBO Journal
7184:
7178:
7177:
7149:
7143:
7142:
7132:
7109:The EMBO Journal
7100:
7094:
7093:
7083:
7051:
7045:
7044:
7034:
7002:
6996:
6995:
6985:
6975:
6951:
6945:
6944:
6934:
6924:
6892:
6886:
6885:
6883:
6881:
6876:on 6 August 2020
6875:
6869:. Archived from
6828:
6819:
6813:
6812:
6802:
6762:
6756:
6755:
6745:
6735:
6718:(21): 11319–24.
6703:
6697:
6696:
6668:
6662:
6661:
6633:
6627:
6626:
6616:
6606:
6574:
6568:
6567:
6549:
6517:
6511:
6510:
6500:
6490:
6466:
6455:
6454:
6444:
6412:
6406:
6405:
6395:
6385:
6361:
6355:
6354:
6344:
6333:10.1038/nsmb1041
6312:
6303:
6302:
6292:
6260:
6254:
6253:
6243:
6219:
6213:
6212:
6202:
6173:Bass BL (2002).
6170:
6164:
6163:
6153:
6121:
6115:
6114:
6104:
6094:
6062:
6056:
6055:
6045:
6021:
6015:
6014:
6004:
5994:
5977:(46): 17337–42.
5962:
5956:
5955:
5919:
5913:
5912:
5894:
5877:(5588): 1833–7.
5862:
5856:
5855:
5822:(5790): 1134–7.
5811:
5805:
5804:
5794:
5754:
5748:
5747:
5711:
5705:
5704:
5703:
5697:
5678:10.1038/35005107
5647:
5641:
5640:
5604:
5598:
5597:
5587:
5563:
5557:
5556:
5520:
5514:
5513:
5503:
5471:
5465:
5464:
5428:
5422:
5421:
5411:
5386:(7033): 666–70.
5371:
5365:
5364:
5320:
5314:
5313:
5303:
5271:
5265:
5264:
5254:
5230:
5224:
5223:
5187:
5178:
5177:
5167:
5135:
5129:
5128:
5116:
5106:
5097:
5096:
5086:
5062:
5056:
5055:
5022:(5641): 1921–5.
5011:
5005:
5004:
4994:
4984:
4960:
4954:
4953:
4943:
4933:
4909:
4903:
4902:
4892:
4882:
4858:
4852:
4851:
4841:
4831:
4807:
4801:
4800:
4790:
4758:
4752:
4751:
4741:
4701:
4695:
4694:
4650:
4644:
4643:
4610:(7027): 769–73.
4599:
4593:
4592:
4582:
4550:
4541:
4538:
4532:
4531:
4521:
4497:
4491:
4490:
4480:
4448:
4442:
4441:
4418:Trends Cell Biol
4413:
4407:
4406:
4396:
4364:
4358:
4357:
4313:
4307:
4306:
4272:
4266:
4265:
4237:
4219:
4187:
4181:
4180:
4178:
4176:
4168:
4157:Retraction Watch
4136:
4092:
4083:
4082:
4038:
4029:
4028:
3992:
3983:
3982:
3972:
3940:
3927:
3926:
3892:
3886:
3885:
3852:(5571): 1270–3.
3841:
3835:
3834:
3824:
3792:
3786:
3785:
3775:
3743:
3734:
3733:
3723:
3691:
3682:
3681:
3671:
3646:(7228): 426–33.
3631:
3621:
3589:
3579:
3555:
3511:
3505:
3504:
3503:
3497:
3478:10.1038/35053110
3453:
3447:
3446:
3420:
3400:
3394:
3393:
3391:
3389:
3380:. Archived from
3369:
3356:
3355:
3311:
3305:
3304:
3294:
3262:
3249:
3248:
3238:
3214:
3205:
3204:
3186:
3154:
3148:
3147:
3137:
3103:
3081:
3076:
3075:
3067:
3062:
3061:
2768:Transgenic crops
2755:and reasons for
2314:apolipoprotein E
1842:Cyclodextrin NP
1582:Delivery System
1573:
1572:
1403:conditional RNAi
1293:Aquifex aeolicus
1198:undifferentiated
1172:that may act as
1113:genetic material
1095:
1092:
1086:
1074:
1073:
1066:
1014:Candida albicans
983:Leishmania major
976:Some eukaryotic
971:polyadenine tail
969:with the mRNA's
927:is processed by
742:and a conserved
674:passenger strand
495:As of 2023, the
226:RNA-coding genes
164:living organisms
98:ribonucleic acid
71:shared the 2006
33:RNA interference
13460:
13459:
13455:
13454:
13453:
13451:
13450:
13449:
13440:Gene expression
13420:
13419:
13416:
13411:
13403:
13394:
13381:
13372:
13361:
13353:
13340:
13328:
13320:
13309:
13301:
13292:
13283:
13278:quantum machine
13275:
13265:
13257:
13249:
13240:
13231:
13220:
13212:
13204:
13192:
13184:
13176:
13168:
13163:Dolly the sheep
13160:
13151:
13144:
13134:
13126:
13092:Wayback Machine
13048:Wayback Machine
12999:
12994:
12993:
12980:
12979:
12975:
12915:
12911:
12890:(19): 1773–80.
12880:
12876:
12837:
12833:
12796:
12792:
12782:
12762:10.1038/418038a
12734:
12730:
12683:
12679:
12669:
12667:
12657:
12653:
12602:
12598:
12553:
12546:
12509:
12505:
12468:
12464:
12433:
12429:
12374:
12370:
12341:(6619): 781–2.
12331:
12327:
12320:
12306:
12302:
12275:Petunia hybrida
12269:
12265:
12236:(22): 3343–53.
12226:
12222:
12177:
12173:
12118:
12114:
12067:
12063:
12056:
12040:
12036:
12029:
12007:
12003:
11950:
11946:
11931:
11909:
11905:
11874:
11870:
11847:10.1038/nbt1118
11841:(8): 995–1001.
11831:
11827:
11760:
11751:
11697:
11691:
11687:
11671:1854/LU-1101411
11634:
11630:
11593:
11589:
11530:
11526:
11481:
11477:
11413:
11406:
11377:(5): 1579–605.
11367:
11363:
11324:
11320:
11272:
11268:
11229:
11225:
11188:
11184:
11151:(48): 18054–9.
11137:
11133:
11094:
11065:
11020:
11016:
10961:
10957:
10920:
10916:
10871:
10867:
10822:
10818:
10779:
10775:
10746:
10725:
10688:
10684:
10647:
10643:
10612:
10608:
10571:
10567:
10522:
10518:
10499:Acta Virologica
10495:
10491:
10444:
10433:
10401:
10397:
10366:
10362:
10323:
10319:
10288:(20): 1679–85.
10274:
10270:
10225:
10221:
10184:
10180:
10157:
10153:
10118:
10114:
10077:
10073:
10038:
10034:
9989:
9985:
9938:
9934:
9889:
9885:
9840:
9836:
9821:
9817:
9802:
9798:
9773:
9751:
9747:
9708:
9704:
9659:
9655:
9630:10.1038/nrg3978
9610:
9606:
9567:
9560:
9505:
9501:
9491:
9489:
9481:
9480:
9476:
9461:
9457:
9412:
9408:
9395:
9394:
9390:
9377:
9376:
9372:
9359:
9358:
9354:
9349:. 5 April 2022.
9341:
9340:
9336:
9291:
9287:
9240:
9236:
9191:
9187:
9148:
9144:
9131:
9130:
9126:
9087:
9083:
9070:
9069:
9065:
9052:
9051:
9047:
8994:
8990:
8947:
8943:
8900:
8896:
8841:
8834:
8793:(28): 10380–5.
8779:
8775:
8734:(19): 7347–51.
8720:
8716:
8669:(5567): 550–3.
8655:
8651:
8614:
8610:
8565:
8561:
8516:
8512:
8467:
8463:
8418:
8414:
8369:
8365:
8320:
8316:
8285:
8281:
8236:
8232:
8187:
8183:
8146:
8142:
8103:
8099:
8062:
8058:
8007:
8003:
7966:
7962:
7925:(5631): 336–8.
7911:
7907:
7868:(26): 5965–73.
7854:
7850:
7811:(6155): 231–4.
7797:
7793:
7754:(6155): 235–8.
7740:
7736:
7697:
7693:
7656:
7652:
7599:
7595:
7548:
7544:
7491:
7487:
7448:(5772): 452–4.
7434:
7430:
7385:
7381:
7342:
7338:
7297:(47): 18002–7.
7283:
7279:
7248:(12): 5747–56.
7234:
7230:
7185:
7181:
7150:
7146:
7115:(15): 4738–45.
7101:
7097:
7066:(21): 6233–46.
7052:
7048:
7003:
6999:
6952:
6948:
6907:(13): 4858–63.
6893:
6889:
6879:
6877:
6873:
6826:
6820:
6816:
6763:
6759:
6704:
6700:
6669:
6665:
6634:
6630:
6589:(47): 16961–6.
6575:
6571:
6526:Current Biology
6518:
6514:
6467:
6458:
6433:10.1038/nrm2061
6413:
6409:
6362:
6358:
6313:
6306:
6261:
6257:
6220:
6216:
6171:
6167:
6136:(11): 4028–40.
6122:
6118:
6063:
6059:
6036:(11): 1174–80.
6030:Nature Genetics
6022:
6018:
5963:
5959:
5920:
5916:
5863:
5859:
5812:
5808:
5769:(5658): 672–6.
5755:
5751:
5712:
5708:
5698:
5664:(6775): 293–6.
5648:
5644:
5621:10.1038/ncb1334
5615:(12): 1267–74.
5605:
5601:
5564:
5560:
5537:10.1038/ncb1265
5521:
5517:
5472:
5468:
5433:Differentiation
5429:
5425:
5372:
5368:
5321:
5317:
5280:Current Biology
5272:
5268:
5231:
5227:
5204:10.1038/nsmb780
5188:
5181:
5136:
5132:
5125:
5107:
5100:
5063:
5059:
5012:
5008:
4992:1959.13/1335073
4961:
4957:
4910:
4906:
4859:
4855:
4808:
4804:
4759:
4755:
4716:(7209): 64–71.
4702:
4698:
4661:(7209): 58–63.
4651:
4647:
4600:
4596:
4551:
4544:
4539:
4535:
4498:
4494:
4463:(14): 1655–66.
4449:
4445:
4414:
4410:
4365:
4361:
4324:(5671): 734–6.
4314:
4310:
4295:
4273:
4269:
4238:
4188:
4184:
4170:
4162:
4160:
4137:
4103:(5809): 244–7.
4093:
4086:
4049:(5809): 241–4.
4039:
4032:
3993:
3986:
3941:
3930:
3915:
3893:
3889:
3842:
3838:
3793:
3789:
3744:
3737:
3692:
3685:
3632:
3590:
3556:
3512:
3508:
3498:
3464:(6818): 363–6.
3454:
3450:
3418:10.1.1.456.1701
3401:
3397:
3387:
3385:
3370:
3359:
3322:(5758): 195–8.
3312:
3308:
3277:(6147): 732–3.
3263:
3252:
3215:
3208:
3155:
3151:
3104:
3100:
3095:
3077:
3070:
3063:
3056:
3053:
3010:clinical trials
2990:
2854:
2849:
2833:gene expression
2825:
2797:
2780:
2765:
2753:modes of action
2729:. While in the
2682:Diuraphis noxia
2660:Musca domestica
2590:
2582:hexaploid wheat
2578:wheat leaf rust
2505:dietary protein
2497:
2480:
2452:
2419:
2399:influenza virus
2378:
2376:Viral infection
2366:
2358:steatohepatitis
2337:
2259:
2236:
2227:
2137:Marina Biotech
1516:porphobilinogen
1500:priority review
1417:A normal adult
1411:
1370:innate immunity
1328:
1311:
1306:
1256:parsimony-based
1252:
1206:gene expression
1182:
1174:heterochromatin
1151:innate immunity
1109:immune response
1105:
1096:
1090:
1087:
1084:
1075:
1071:
1064:
1047:
1025:. That certain
942:
886:
812:heterochromatin
768:
701:of the binding
656:to their bound
531:
471:
465:
373:gene expression
369:non-coding RNAs
358:
328:
184:
45:gene expression
17:
12:
11:
5:
13458:
13448:
13447:
13442:
13437:
13432:
13413:
13412:
13410:
13409:
13401:
13392:
13379:
13370:
13359:
13351:
13338:
13326:
13318:
13307:
13299:
13290:
13288:clinical trial
13281:
13273:
13263:
13255:
13247:
13238:
13229:
13218:
13210:
13202:
13190:
13182:
13174:
13166:
13158:
13148:
13146:
13136:
13135:
13125:
13124:
13117:
13110:
13102:
13096:
13095:
13082:
13076:
13067:
13056:
13051:
13038:
13037:, 26 July 2005
13022:
13011:
12998:
12997:External links
12995:
12992:
12991:
12973:
12909:
12874:
12831:
12790:
12748:(6893): 38–9.
12728:
12677:
12665:nobelprize.org
12651:
12596:
12544:
12503:
12462:
12427:
12388:(5): 1679–83.
12368:
12325:
12318:
12300:
12263:
12220:
12191:(4): 279–289.
12185:The Plant Cell
12171:
12132:(15): 5372–6.
12112:
12061:
12054:
12034:
12027:
12001:
11944:
11929:
11903:
11868:
11825:
11778:Annual Reviews
11749:
11712:Annual Reviews
11685:
11628:
11587:
11548:(10): e47431.
11524:
11475:
11419:Phytopathology
11404:
11361:
11318:
11266:
11245:10.1038/nbt966
11223:
11182:
11131:
11063:
11014:
10975:(16): 5820–5.
10955:
10914:
10865:
10836:(9): 1563–73.
10816:
10795:10.1038/nn1531
10789:(10): 1343–9.
10773:
10723:
10682:
10641:
10606:
10565:
10516:
10489:
10431:
10395:
10360:
10327:Avian Diseases
10317:
10268:
10219:
10198:(39): 6041–8.
10178:
10151:
10112:
10091:(6): 655–677.
10071:
10052:(2): 137–148.
10032:
9983:
9932:
9883:
9854:(5): 403–416.
9834:
9815:
9796:
9771:
9745:
9718:(3): 438–449.
9702:
9653:
9604:
9577:(11): 967–77.
9558:
9499:
9474:
9455:
9406:
9388:
9370:
9352:
9334:
9305:(3): 313–317.
9285:
9234:
9205:(5): 527–537.
9185:
9142:
9124:
9081:
9063:
9060:. 10 May 2021.
9045:
8988:
8941:
8894:
8832:
8773:
8714:
8649:
8608:
8559:
8510:
8461:
8412:
8363:
8314:
8279:
8250:(7): 1427–64.
8230:
8181:
8140:
8097:
8056:
8001:
7960:
7905:
7848:
7791:
7734:
7713:10.1038/ni1352
7691:
7650:
7593:
7542:
7485:
7428:
7379:
7346:Science's STKE
7336:
7277:
7228:
7199:(7): 1672–80.
7179:
7144:
7095:
7046:
7017:(3): 299–306.
6997:
6960:Biology Direct
6946:
6887:
6814:
6757:
6698:
6663:
6628:
6569:
6532:(10): 747–57.
6512:
6456:
6427:(12): 919–31.
6407:
6376:(5): 3946–53.
6356:
6304:
6255:
6214:
6165:
6116:
6057:
6043:10.1038/ng1452
6016:
5957:
5914:
5857:
5806:
5749:
5706:
5642:
5599:
5558:
5515:
5466:
5423:
5366:
5315:
5266:
5245:(2): 199–208.
5225:
5198:(7): 599–606.
5179:
5130:
5123:
5098:
5057:
5006:
4955:
4904:
4853:
4802:
4753:
4696:
4645:
4594:
4542:
4533:
4492:
4443:
4408:
4359:
4308:
4293:
4267:
4182:
4084:
4030:
3984:
3928:
3913:
3887:
3836:
3801:Molecular Cell
3787:
3735:
3706:(6): 1834–47.
3683:
3506:
3448:
3395:
3357:
3306:
3250:
3206:
3149:
3097:
3096:
3094:
3091:
3090:
3089:
3083:
3082:
3079:Viruses portal
3068:
3065:Biology portal
3052:
3049:
2989:
2986:
2958:Craig C. Mello
2853:
2852:RNAi discovery
2850:
2848:
2845:
2824:
2821:
2796:
2793:
2779:
2776:
2764:
2761:
2650:Apis mellifera
2589:
2586:
2496:
2493:
2479:
2476:
2451:
2448:
2418:
2415:
2377:
2374:
2365:
2362:
2336:
2333:
2258:
2255:
2235:
2232:
2226:
2223:
2220:
2219:
2216:
2213:
2210:
2207:
2204:
2201:
2198:
2194:
2193:
2190:
2187:
2184:
2181:
2178:
2175:
2172:
2168:
2167:
2164:
2161:
2158:
2155:
2152:
2149:
2146:
2142:
2141:
2138:
2135:
2132:
2129:
2126:
2123:
2120:
2116:
2115:
2112:
2109:
2106:
2103:
2100:
2097:
2094:
2090:
2089:
2086:
2083:
2080:
2077:
2074:
2071:
2068:
2064:
2063:
2060:
2057:
2054:
2051:
2048:
2045:
2042:
2038:
2037:
2034:
2031:
2028:
2025:
2022:
2021:LODER polymer
2019:
2016:
2012:
2011:
2008:
2005:
2002:
1999:
1996:
1993:
1990:
1986:
1985:
1982:
1979:
1976:
1973:
1970:
1968:
1966:
1963:
1962:
1959:
1956:
1953:
1950:
1947:
1944:
1941:
1937:
1936:
1933:
1930:
1927:
1924:
1921:
1918:
1915:
1911:
1910:
1907:
1904:
1901:
1898:
1895:
1892:
1889:
1885:
1884:
1881:
1878:
1875:
1872:
1869:
1866:
1863:
1859:
1858:
1855:
1852:
1849:
1846:
1845:Solid tumours
1843:
1840:
1837:
1833:
1832:
1829:
1826:
1823:
1820:
1817:
1814:
1811:
1807:
1806:
1803:
1800:
1797:
1794:
1791:
1788:
1785:
1781:
1780:
1777:
1774:
1771:
1768:
1765:
1762:
1759:
1755:
1754:
1751:
1748:
1745:
1742:
1739:
1736:
1733:
1729:
1728:
1725:
1722:
1719:
1716:
1713:
1710:
1707:
1703:
1702:
1699:
1696:
1693:
1690:
1687:
1684:
1681:
1677:
1676:
1673:
1670:
1667:
1664:
1663:Solid tumours
1661:
1658:
1655:
1651:
1650:
1647:
1644:
1641:
1638:
1635:
1632:
1629:
1625:
1624:
1621:
1618:
1615:
1612:
1611:Solid tumours
1609:
1606:
1603:
1599:
1598:
1595:
1592:
1589:
1586:
1583:
1580:
1577:
1520:GalNAc ligands
1410:
1407:
1327:
1324:
1314:Gene knockdown
1310:
1307:
1305:
1302:
1261:analysis, the
1251:
1248:
1228:F-box proteins
1181:
1178:
1104:
1101:
1098:
1097:
1078:
1076:
1069:
1063:
1060:
1046:
1043:
1031:basidiomycetes
998:model organism
941:
938:
885:
882:
869:RNA polymerase
767:
764:
707:phosphorylated
614:A full-length
530:
527:
519:epigenetically
467:Main article:
464:
461:
415:enzyme called
354:Main article:
327:
324:
249:Bioinformatics
210:gene silencing
183:
180:
69:Craig C. Mello
53:co-suppression
15:
9:
6:
4:
3:
2:
13457:
13446:
13443:
13441:
13438:
13436:
13433:
13431:
13428:
13427:
13425:
13418:
13407:
13402:
13398:
13393:
13389:
13385:
13380:
13376:
13371:
13368:
13365:
13360:
13357:
13352:
13348:
13344:
13339:
13336:
13332:
13327:
13324:
13319:
13316:
13315:comet mission
13314:
13308:
13305:
13300:
13296:
13291:
13287:
13282:
13279:
13274:
13271:
13270:
13264:
13261:
13256:
13253:
13248:
13244:
13239:
13235:
13230:
13227:
13225:
13219:
13216:
13211:
13208:
13203:
13200:
13196:
13191:
13188:
13183:
13180:
13175:
13172:
13167:
13164:
13159:
13156:understanding
13155:
13150:
13149:
13147:
13143:
13142:
13137:
13133:
13131:
13123:
13118:
13116:
13111:
13109:
13104:
13103:
13100:
13093:
13089:
13086:
13083:
13080:
13077:
13074:
13072:
13068:
13066:
13065:
13060:
13057:
13055:
13052:
13049:
13045:
13042:
13039:
13036:
13032:
13031:
13026:
13023:
13021:
13020:
13015:
13012:
13010:
13009:
13004:
13001:
13000:
12987:
12983:
12977:
12969:
12965:
12960:
12955:
12951:
12947:
12943:
12939:
12935:
12931:
12927:
12923:
12919:
12913:
12905:
12901:
12897:
12893:
12889:
12885:
12878:
12870:
12866:
12862:
12858:
12854:
12850:
12846:
12842:
12835:
12827:
12823:
12818:
12813:
12810:(9): 819–29.
12809:
12805:
12801:
12794:
12786:
12779:
12775:
12771:
12767:
12763:
12759:
12755:
12751:
12747:
12743:
12739:
12732:
12724:
12720:
12716:
12712:
12708:
12704:
12700:
12696:
12692:
12688:
12681:
12666:
12662:
12655:
12647:
12643:
12639:
12635:
12631:
12630:10.1038/35888
12627:
12623:
12619:
12615:
12611:
12607:
12600:
12592:
12588:
12584:
12580:
12575:
12570:
12567:(9): 1293–9.
12566:
12562:
12561:FASEB Journal
12558:
12551:
12549:
12540:
12536:
12531:
12526:
12523:(3): 479–90.
12522:
12518:
12514:
12507:
12499:
12495:
12490:
12485:
12482:(4): 611–20.
12481:
12477:
12473:
12466:
12458:
12454:
12450:
12446:
12442:
12438:
12431:
12423:
12419:
12414:
12409:
12404:
12399:
12395:
12391:
12387:
12383:
12379:
12372:
12364:
12360:
12356:
12352:
12348:
12344:
12340:
12336:
12329:
12321:
12315:
12311:
12304:
12295:
12290:
12287:(6): 861–77.
12286:
12282:
12278:
12276:
12267:
12259:
12255:
12251:
12247:
12243:
12239:
12235:
12231:
12224:
12216:
12212:
12207:
12202:
12198:
12194:
12190:
12186:
12182:
12175:
12167:
12163:
12158:
12153:
12148:
12143:
12139:
12135:
12131:
12127:
12123:
12116:
12108:
12104:
12099:
12094:
12089:
12084:
12080:
12076:
12072:
12065:
12057:
12051:
12047:
12046:
12038:
12030:
12024:
12020:
12015:
12014:
12005:
11997:
11993:
11989:
11985:
11980:
11975:
11971:
11967:
11964:(3): 205–12.
11963:
11959:
11955:
11948:
11940:
11936:
11932:
11926:
11922:
11918:
11914:
11907:
11899:
11895:
11891:
11887:
11883:
11879:
11872:
11864:
11860:
11856:
11852:
11848:
11844:
11840:
11836:
11829:
11821:
11817:
11813:
11809:
11804:
11799:
11795:
11791:
11787:
11783:
11779:
11775:
11771:
11770:
11765:
11758:
11756:
11754:
11745:
11741:
11737:
11733:
11729:
11725:
11721:
11717:
11713:
11709:
11705:
11704:
11696:
11689:
11681:
11677:
11672:
11667:
11663:
11659:
11655:
11651:
11648:(2): 231–45.
11647:
11643:
11639:
11632:
11624:
11620:
11615:
11610:
11606:
11602:
11598:
11591:
11583:
11579:
11574:
11569:
11564:
11559:
11555:
11551:
11547:
11543:
11539:
11537:
11528:
11520:
11516:
11511:
11506:
11502:
11498:
11495:(5): 840–50.
11494:
11490:
11486:
11479:
11471:
11467:
11463:
11459:
11455:
11451:
11446:
11441:
11437:
11433:
11429:
11425:
11421:
11420:
11411:
11409:
11400:
11396:
11392:
11388:
11384:
11380:
11376:
11372:
11365:
11357:
11353:
11349:
11345:
11341:
11337:
11334:(2): 248–59.
11333:
11329:
11322:
11314:
11310:
11306:
11302:
11298:
11294:
11290:
11286:
11282:
11278:
11270:
11262:
11258:
11254:
11250:
11246:
11242:
11239:(6): 746–54.
11238:
11234:
11227:
11219:
11215:
11210:
11205:
11202:(2): 231–42.
11201:
11197:
11193:
11186:
11178:
11174:
11169:
11164:
11159:
11154:
11150:
11146:
11142:
11135:
11127:
11123:
11119:
11115:
11111:
11107:
11103:
11099:
11092:
11090:
11088:
11086:
11084:
11082:
11080:
11078:
11076:
11074:
11072:
11070:
11068:
11059:
11055:
11050:
11045:
11041:
11037:
11034:(R1): R21–7.
11033:
11029:
11025:
11018:
11010:
11006:
11001:
10996:
10991:
10986:
10982:
10978:
10974:
10970:
10966:
10959:
10951:
10947:
10942:
10937:
10934:(6): 487–95.
10933:
10929:
10925:
10918:
10910:
10906:
10901:
10896:
10892:
10888:
10884:
10880:
10876:
10869:
10861:
10857:
10852:
10847:
10843:
10839:
10835:
10831:
10827:
10820:
10812:
10808:
10804:
10800:
10796:
10792:
10788:
10784:
10777:
10768:
10763:
10759:
10755:
10751:
10744:
10742:
10740:
10738:
10736:
10734:
10732:
10730:
10728:
10719:
10715:
10710:
10705:
10701:
10697:
10693:
10686:
10678:
10674:
10669:
10664:
10661:(2): 125–33.
10660:
10656:
10652:
10645:
10637:
10633:
10629:
10625:
10622:(5): 507–17.
10621:
10617:
10610:
10602:
10598:
10593:
10588:
10584:
10580:
10576:
10569:
10561:
10557:
10552:
10547:
10543:
10539:
10535:
10531:
10527:
10520:
10512:
10508:
10505:(4): 227–34.
10504:
10500:
10493:
10485:
10481:
10476:
10471:
10466:
10461:
10457:
10453:
10449:
10442:
10440:
10438:
10436:
10427:
10423:
10419:
10415:
10412:(6): 414–22.
10411:
10407:
10399:
10391:
10387:
10383:
10379:
10376:(1): 131–40.
10375:
10371:
10364:
10356:
10352:
10348:
10344:
10340:
10336:
10333:(4): 562–73.
10332:
10328:
10321:
10313:
10309:
10305:
10301:
10296:
10291:
10287:
10283:
10279:
10272:
10264:
10260:
10255:
10250:
10246:
10242:
10238:
10234:
10230:
10223:
10215:
10211:
10206:
10201:
10197:
10193:
10189:
10182:
10174:
10170:
10166:
10162:
10155:
10147:
10143:
10139:
10135:
10131:
10127:
10123:
10116:
10108:
10104:
10099:
10094:
10090:
10086:
10082:
10075:
10067:
10063:
10059:
10055:
10051:
10047:
10043:
10036:
10028:
10024:
10020:
10016:
10011:
10006:
10002:
9998:
9994:
9987:
9979:
9975:
9970:
9965:
9960:
9955:
9951:
9947:
9943:
9936:
9928:
9924:
9919:
9914:
9910:
9906:
9902:
9898:
9894:
9887:
9879:
9875:
9870:
9865:
9861:
9857:
9853:
9849:
9845:
9838:
9830:
9829:The Scientist
9826:
9819:
9811:
9807:
9800:
9792:
9788:
9783:
9778:
9774:
9768:
9764:
9760:
9756:
9749:
9741:
9737:
9733:
9729:
9725:
9721:
9717:
9713:
9706:
9698:
9694:
9689:
9684:
9680:
9676:
9672:
9668:
9664:
9657:
9649:
9645:
9640:
9635:
9631:
9627:
9624:(9): 543–52.
9623:
9619:
9615:
9608:
9600:
9596:
9592:
9588:
9584:
9580:
9576:
9572:
9565:
9563:
9554:
9550:
9545:
9540:
9536:
9532:
9527:
9522:
9518:
9514:
9510:
9503:
9488:
9484:
9478:
9470:
9466:
9459:
9451:
9447:
9443:
9439:
9434:
9429:
9425:
9421:
9417:
9410:
9402:
9398:
9392:
9384:
9380:
9374:
9366:
9362:
9356:
9348:
9344:
9338:
9330:
9326:
9321:
9316:
9312:
9308:
9304:
9300:
9296:
9289:
9281:
9277:
9272:
9267:
9262:
9257:
9253:
9249:
9245:
9238:
9230:
9226:
9221:
9216:
9212:
9208:
9204:
9200:
9196:
9189:
9181:
9177:
9173:
9169:
9165:
9161:
9157:
9153:
9146:
9138:
9134:
9128:
9120:
9116:
9112:
9108:
9104:
9100:
9096:
9092:
9085:
9077:
9073:
9067:
9059:
9055:
9049:
9041:
9037:
9033:
9029:
9024:
9019:
9015:
9011:
9007:
9003:
8999:
8992:
8984:
8980:
8976:
8972:
8968:
8964:
8960:
8956:
8952:
8945:
8937:
8933:
8929:
8925:
8921:
8917:
8913:
8909:
8905:
8898:
8890:
8886:
8882:
8878:
8873:
8868:
8863:
8858:
8854:
8850:
8846:
8839:
8837:
8828:
8824:
8819:
8814:
8809:
8804:
8800:
8796:
8792:
8788:
8784:
8777:
8769:
8765:
8760:
8755:
8750:
8745:
8741:
8737:
8733:
8729:
8725:
8718:
8710:
8706:
8702:
8698:
8693:
8688:
8684:
8680:
8676:
8672:
8668:
8664:
8660:
8653:
8645:
8641:
8636:
8631:
8628:(2): 464–71.
8627:
8623:
8619:
8612:
8604:
8600:
8595:
8590:
8586:
8582:
8579:(6): 988–93.
8578:
8574:
8570:
8563:
8555:
8551:
8546:
8541:
8537:
8533:
8529:
8525:
8521:
8514:
8506:
8502:
8497:
8492:
8488:
8484:
8480:
8476:
8472:
8465:
8457:
8453:
8448:
8443:
8439:
8435:
8431:
8427:
8423:
8416:
8408:
8404:
8399:
8394:
8390:
8386:
8382:
8378:
8374:
8367:
8359:
8355:
8350:
8345:
8341:
8337:
8333:
8329:
8325:
8318:
8310:
8306:
8302:
8298:
8294:
8290:
8283:
8275:
8271:
8266:
8261:
8257:
8253:
8249:
8245:
8241:
8234:
8226:
8222:
8217:
8212:
8208:
8204:
8200:
8196:
8192:
8185:
8177:
8173:
8168:
8163:
8159:
8155:
8151:
8144:
8136:
8132:
8128:
8124:
8120:
8116:
8112:
8108:
8101:
8093:
8089:
8084:
8079:
8075:
8071:
8067:
8060:
8052:
8048:
8044:
8040:
8036:
8032:
8028:
8024:
8020:
8016:
8012:
8005:
7997:
7993:
7988:
7983:
7980:(5): 843–54.
7979:
7975:
7971:
7964:
7956:
7952:
7948:
7944:
7940:
7936:
7932:
7928:
7924:
7920:
7916:
7909:
7901:
7897:
7892:
7887:
7883:
7879:
7875:
7871:
7867:
7863:
7859:
7852:
7844:
7840:
7835:
7830:
7826:
7822:
7818:
7814:
7810:
7806:
7802:
7795:
7787:
7783:
7778:
7773:
7769:
7765:
7761:
7757:
7753:
7749:
7745:
7738:
7730:
7726:
7722:
7718:
7714:
7710:
7706:
7702:
7695:
7687:
7683:
7678:
7673:
7669:
7665:
7661:
7654:
7646:
7642:
7637:
7632:
7628:
7624:
7620:
7616:
7612:
7608:
7604:
7597:
7589:
7585:
7581:
7577:
7573:
7569:
7565:
7561:
7557:
7553:
7546:
7538:
7534:
7529:
7524:
7520:
7516:
7512:
7508:
7504:
7500:
7496:
7489:
7481:
7477:
7472:
7467:
7463:
7459:
7455:
7451:
7447:
7443:
7439:
7432:
7424:
7420:
7416:
7412:
7407:
7402:
7398:
7394:
7390:
7383:
7375:
7371:
7367:
7363:
7359:
7355:
7352:(339): pe27.
7351:
7347:
7340:
7332:
7328:
7323:
7318:
7313:
7308:
7304:
7300:
7296:
7292:
7288:
7281:
7273:
7269:
7264:
7259:
7255:
7251:
7247:
7243:
7239:
7232:
7224:
7220:
7215:
7210:
7206:
7202:
7198:
7194:
7190:
7183:
7175:
7171:
7167:
7163:
7160:(8): 449–59.
7159:
7155:
7148:
7140:
7136:
7131:
7126:
7122:
7118:
7114:
7110:
7106:
7099:
7091:
7087:
7082:
7077:
7073:
7069:
7065:
7061:
7057:
7050:
7042:
7038:
7033:
7028:
7024:
7020:
7016:
7012:
7008:
7001:
6993:
6989:
6984:
6979:
6974:
6969:
6965:
6961:
6957:
6950:
6942:
6938:
6933:
6928:
6923:
6918:
6914:
6910:
6906:
6902:
6898:
6891:
6872:
6868:
6864:
6860:
6856:
6852:
6848:
6844:
6840:
6837:(1): 127–35.
6836:
6832:
6825:
6818:
6810:
6806:
6801:
6796:
6792:
6788:
6784:
6780:
6776:
6772:
6768:
6761:
6753:
6749:
6744:
6739:
6734:
6729:
6725:
6721:
6717:
6713:
6709:
6702:
6694:
6690:
6686:
6682:
6679:(2): 217–28.
6678:
6674:
6667:
6659:
6655:
6651:
6647:
6644:(2): 175–86.
6643:
6639:
6632:
6624:
6620:
6615:
6610:
6605:
6600:
6596:
6592:
6588:
6584:
6580:
6573:
6565:
6561:
6557:
6553:
6548:
6543:
6539:
6535:
6531:
6527:
6523:
6516:
6508:
6504:
6499:
6494:
6489:
6484:
6480:
6476:
6475:Retrovirology
6472:
6465:
6463:
6461:
6452:
6448:
6443:
6438:
6434:
6430:
6426:
6422:
6418:
6411:
6403:
6399:
6394:
6389:
6384:
6379:
6375:
6371:
6367:
6360:
6352:
6348:
6343:
6338:
6334:
6330:
6326:
6322:
6318:
6311:
6309:
6300:
6296:
6291:
6286:
6282:
6278:
6275:(8): 1174–7.
6274:
6270:
6266:
6259:
6251:
6247:
6242:
6237:
6233:
6229:
6225:
6218:
6210:
6206:
6201:
6196:
6192:
6188:
6184:
6180:
6176:
6169:
6161:
6157:
6152:
6147:
6143:
6139:
6135:
6131:
6127:
6120:
6112:
6108:
6103:
6098:
6093:
6088:
6084:
6080:
6076:
6072:
6068:
6061:
6053:
6049:
6044:
6039:
6035:
6031:
6027:
6020:
6012:
6008:
6003:
5998:
5993:
5988:
5984:
5980:
5976:
5972:
5968:
5961:
5953:
5949:
5945:
5941:
5937:
5933:
5930:(2): 137–46.
5929:
5925:
5918:
5910:
5906:
5902:
5898:
5893:
5888:
5884:
5880:
5876:
5872:
5868:
5861:
5853:
5849:
5845:
5841:
5837:
5833:
5829:
5825:
5821:
5817:
5810:
5802:
5798:
5793:
5788:
5784:
5780:
5776:
5772:
5768:
5764:
5760:
5753:
5745:
5741:
5737:
5733:
5729:
5725:
5722:(2): 96–125.
5721:
5717:
5710:
5702:
5695:
5691:
5687:
5683:
5679:
5675:
5671:
5667:
5663:
5659:
5658:
5653:
5646:
5638:
5634:
5630:
5626:
5622:
5618:
5614:
5610:
5609:Nat Cell Biol
5603:
5595:
5591:
5586:
5581:
5577:
5573:
5569:
5562:
5554:
5550:
5546:
5542:
5538:
5534:
5530:
5526:
5525:Nat Cell Biol
5519:
5511:
5507:
5502:
5497:
5493:
5489:
5485:
5481:
5477:
5470:
5462:
5458:
5454:
5450:
5446:
5442:
5439:(6): 287–93.
5438:
5434:
5427:
5419:
5415:
5410:
5405:
5401:
5397:
5393:
5389:
5385:
5381:
5377:
5370:
5362:
5358:
5354:
5350:
5346:
5342:
5338:
5334:
5330:
5326:
5319:
5311:
5307:
5302:
5297:
5293:
5289:
5285:
5281:
5277:
5270:
5262:
5258:
5253:
5248:
5244:
5240:
5236:
5229:
5221:
5217:
5213:
5209:
5205:
5201:
5197:
5193:
5186:
5184:
5175:
5171:
5166:
5161:
5157:
5153:
5150:(3): 314–20.
5149:
5145:
5141:
5134:
5126:
5120:
5115:
5114:
5105:
5103:
5094:
5090:
5085:
5080:
5077:(4): 631–40.
5076:
5072:
5068:
5061:
5053:
5049:
5045:
5041:
5037:
5033:
5029:
5025:
5021:
5017:
5010:
5002:
4998:
4993:
4988:
4983:
4978:
4974:
4970:
4966:
4959:
4951:
4947:
4942:
4937:
4932:
4927:
4923:
4919:
4915:
4908:
4900:
4896:
4891:
4886:
4881:
4876:
4872:
4868:
4864:
4857:
4849:
4845:
4840:
4835:
4830:
4825:
4821:
4817:
4813:
4806:
4798:
4794:
4789:
4784:
4780:
4776:
4773:(3): 363–70.
4772:
4768:
4764:
4757:
4749:
4745:
4740:
4735:
4731:
4727:
4723:
4719:
4715:
4711:
4707:
4700:
4692:
4688:
4684:
4680:
4676:
4672:
4668:
4664:
4660:
4656:
4649:
4641:
4637:
4633:
4629:
4625:
4621:
4617:
4613:
4609:
4605:
4598:
4590:
4586:
4581:
4576:
4572:
4568:
4565:(1): 92–105.
4564:
4560:
4556:
4549:
4547:
4537:
4529:
4525:
4520:
4515:
4511:
4507:
4503:
4496:
4488:
4484:
4479:
4474:
4470:
4466:
4462:
4458:
4454:
4447:
4439:
4435:
4431:
4427:
4424:(3): 118–26.
4423:
4419:
4412:
4404:
4400:
4395:
4390:
4386:
4382:
4378:
4374:
4370:
4363:
4355:
4351:
4347:
4343:
4339:
4335:
4331:
4327:
4323:
4319:
4312:
4304:
4300:
4296:
4290:
4286:
4282:
4278:
4271:
4263:
4259:
4255:
4251:
4248:(4): 189–97.
4247:
4243:
4235:
4231:
4227:
4223:
4218:
4213:
4209:
4205:
4201:
4197:
4193:
4186:
4174:
4166:
4159:
4158:
4153:
4149:
4145:
4141:
4134:
4130:
4126:
4122:
4118:
4114:
4110:
4106:
4102:
4098:
4091:
4089:
4080:
4076:
4072:
4068:
4064:
4060:
4056:
4052:
4048:
4044:
4037:
4035:
4026:
4022:
4018:
4014:
4010:
4006:
4002:
3998:
3991:
3989:
3980:
3976:
3971:
3966:
3962:
3958:
3955:(5): 807–18.
3954:
3950:
3946:
3939:
3937:
3935:
3933:
3924:
3920:
3916:
3910:
3906:
3902:
3898:
3891:
3883:
3879:
3875:
3871:
3867:
3863:
3859:
3855:
3851:
3847:
3840:
3832:
3828:
3823:
3818:
3814:
3810:
3807:(5): 807–18.
3806:
3802:
3798:
3791:
3783:
3779:
3774:
3769:
3765:
3761:
3758:(5): 637–60.
3757:
3753:
3749:
3742:
3740:
3731:
3727:
3722:
3717:
3713:
3709:
3705:
3701:
3697:
3690:
3688:
3679:
3675:
3670:
3665:
3661:
3657:
3653:
3649:
3645:
3641:
3637:
3629:
3625:
3620:
3615:
3611:
3607:
3604:(5): 674–82.
3603:
3599:
3595:
3587:
3583:
3578:
3573:
3569:
3565:
3561:
3553:
3549:
3545:
3541:
3537:
3533:
3529:
3525:
3521:
3517:
3510:
3502:
3495:
3491:
3487:
3483:
3479:
3475:
3471:
3467:
3463:
3459:
3452:
3444:
3440:
3436:
3432:
3428:
3424:
3419:
3414:
3411:(6): 545–53.
3410:
3406:
3399:
3383:
3379:
3375:
3368:
3366:
3364:
3362:
3353:
3349:
3345:
3341:
3337:
3333:
3329:
3325:
3321:
3317:
3310:
3302:
3298:
3293:
3288:
3284:
3280:
3276:
3272:
3268:
3261:
3259:
3257:
3255:
3246:
3242:
3237:
3232:
3229:(4): 607–20.
3228:
3224:
3220:
3213:
3211:
3202:
3198:
3194:
3190:
3185:
3180:
3176:
3172:
3169:(3): 334–58.
3168:
3164:
3160:
3153:
3145:
3141:
3136:
3131:
3127:
3123:
3120:(3): 543–64.
3119:
3115:
3114:
3109:
3102:
3098:
3088:
3085:
3084:
3080:
3074:
3069:
3066:
3060:
3055:
3048:
3046:
3042:
3038:
3034:
3029:
3027:
3023:
3019:
3015:
3011:
3007:
3003:
2999:
2995:
2985:
2983:
2979:
2975:
2974:antisense RNA
2971:
2967:
2963:
2959:
2954:
2953:
2948:
2947:antisense RNA
2944:
2940:
2935:
2934:
2929:
2924:
2922:
2918:
2917:
2913:
2908:
2904:
2900:
2896:
2892:
2888:
2887:United States
2884:
2880:
2871:
2867:
2863:
2858:
2844:
2841:
2837:
2834:
2830:
2820:
2818:
2814:
2810:
2806:
2802:
2792:
2789:
2785:
2775:
2773:
2769:
2760:
2758:
2754:
2750:
2746:
2745:
2740:
2736:
2732:
2728:
2727:
2722:
2718:
2717:
2712:
2711:
2706:
2705:
2700:
2699:
2694:
2690:
2689:
2684:
2683:
2678:
2674:
2673:
2668:
2667:
2662:
2661:
2656:
2652:
2651:
2646:
2645:
2640:
2639:
2634:
2633:
2628:
2627:
2622:
2621:
2616:
2615:
2610:
2609:
2604:
2602:
2597:
2595:
2585:
2583:
2579:
2575:
2574:
2569:
2565:
2561:
2557:
2553:
2549:
2545:
2541:
2537:
2536:alpha-amylase
2533:
2529:
2525:
2520:
2518:
2514:
2510:
2506:
2502:
2492:
2488:
2484:
2475:
2473:
2469:
2465:
2461:
2457:
2447:
2443:
2439:
2437:
2433:
2429:
2424:
2414:
2412:
2408:
2404:
2403:measles virus
2400:
2396:
2392:
2388:
2384:
2373:
2371:
2370:Arctic apples
2364:Biotechnology
2361:
2359:
2355:
2351:
2347:
2343:
2332:
2330:
2326:
2323:
2319:
2315:
2311:
2307:
2303:
2299:
2294:
2292:
2288:
2284:
2280:
2275:
2273:
2269:
2265:
2254:
2252:
2247:
2242:
2231:
2217:
2214:
2211:
2208:
2205:
2202:
2199:
2196:
2195:
2191:
2188:
2185:
2182:
2179:
2176:
2173:
2170:
2169:
2165:
2162:
2159:
2156:
2153:
2150:
2147:
2144:
2143:
2139:
2136:
2133:
2130:
2127:
2124:
2121:
2118:
2117:
2113:
2110:
2107:
2104:
2101:
2098:
2095:
2092:
2091:
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2017:
2015:siG12D LODER
2014:
2013:
2009:
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1605:KSP and VEGF
1604:
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1581:
1578:
1575:
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1550:transthyretin
1547:
1543:
1538:
1536:
1532:
1528:
1524:
1521:
1517:
1513:
1509:
1505:
1501:
1498:designation,
1497:
1493:
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1477:
1473:
1469:
1465:
1461:
1457:
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1451:
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1268:
1264:
1260:
1257:
1247:
1245:
1241:
1237:
1233:
1229:
1225:
1224:gene networks
1221:
1217:
1216:
1211:
1207:
1203:
1199:
1195:
1194:morphogenesis
1191:
1187:
1177:
1175:
1171:
1166:
1162:
1160:
1156:
1152:
1148:
1143:
1141:
1137:
1133:
1129:
1124:
1120:
1119:
1114:
1110:
1094:
1082:
1077:
1068:
1067:
1059:
1057:
1053:
1042:
1040:
1036:
1032:
1028:
1024:
1023:S. cerevisiae
1020:
1016:
1015:
1010:
1009:
1004:
1003:
999:
995:
991:
990:
985:
984:
979:
974:
972:
968:
963:
959:
958:plasmodesmata
955:
951:
947:
934:
930:
926:
923:or exogenous
922:
917:
913:
911:
907:
903:
899:
895:
891:
881:
879:
874:
870:
866:
865:complementary
863:
859:
854:
852:
851:cell division
848:
844:
840:
836:
835:
829:
825:
824:fission yeast
821:
817:
813:
809:
805:
797:
793:
792:messenger RNA
789:
785:
781:
777:
772:
763:
761:
757:
752:
749:
745:
741:
737:
734:
730:
726:
723:
719:
715:
712:
708:
704:
700:
695:
692:
687:
683:
679:
675:
671:
667:
663:
659:
655:
654:complementary
651:
650:endonucleases
643:
639:
635:
631:
627:
626:
621:
617:
613:
609:
602:
597:
593:
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585:
581:
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522:
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498:
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450:
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435:
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426:
422:
418:
414:
410:
406:
402:
398:
394:
390:
386:
382:
378:
374:
370:
366:
363:(miRNAs) are
362:
357:
350:
349:
344:
340:
337:
332:
323:
321:
317:
313:
309:
305:
301:
296:
294:
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288:
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281:
279:
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271:
266:
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258:
254:
250:
246:
242:
237:
235:
231:
227:
223:
219:
215:
211:
203:
199:
198:
194:protein from
193:
188:
179:
177:
173:
169:
168:cell division
165:
161:
156:
154:
150:
146:
142:
138:
134:
130:
125:
123:
119:
115:
111:
107:
103:
99:
94:
92:
91:Antisense RNA
88:
84:
83:
78:
74:
70:
66:
62:
58:
54:
50:
46:
42:
38:
34:
27:
23:
19:
13417:
13367:made visible
13312:
13276:2010: First
13267:
13223:
13206:
13195:Nanocircuits
13139:
13129:
13070:
13062:
13028:
13017:
13006:
12985:
12976:
12933:
12929:
12912:
12887:
12883:
12877:
12844:
12840:
12834:
12807:
12803:
12793:
12745:
12741:
12731:
12690:
12686:
12680:
12668:. Retrieved
12664:
12654:
12613:
12609:
12599:
12564:
12560:
12520:
12516:
12506:
12479:
12475:
12465:
12440:
12436:
12430:
12385:
12381:
12371:
12338:
12334:
12328:
12309:
12303:
12284:
12280:
12274:
12266:
12233:
12229:
12223:
12188:
12184:
12174:
12129:
12125:
12115:
12078:
12074:
12064:
12044:
12037:
12012:
12004:
11961:
11957:
11947:
11912:
11906:
11884:(2): 723–8.
11881:
11877:
11871:
11838:
11834:
11828:
11773:
11767:
11707:
11701:
11688:
11645:
11641:
11631:
11604:
11600:
11590:
11545:
11541:
11535:
11527:
11492:
11488:
11478:
11423:
11417:
11374:
11370:
11364:
11331:
11327:
11321:
11280:
11276:
11269:
11236:
11232:
11226:
11199:
11195:
11185:
11148:
11144:
11134:
11101:
11097:
11031:
11027:
11017:
10972:
10968:
10958:
10931:
10928:Gene Therapy
10927:
10917:
10882:
10878:
10868:
10833:
10829:
10819:
10786:
10782:
10776:
10757:
10753:
10699:
10695:
10685:
10658:
10654:
10644:
10619:
10615:
10609:
10582:
10578:
10568:
10533:
10529:
10519:
10502:
10498:
10492:
10455:
10451:
10409:
10405:
10398:
10373:
10369:
10363:
10330:
10326:
10320:
10285:
10281:
10271:
10236:
10232:
10222:
10195:
10191:
10181:
10167:(2): 141–5.
10164:
10160:
10154:
10129:
10125:
10115:
10088:
10084:
10074:
10049:
10045:
10035:
10000:
9996:
9986:
9949:
9946:Biomedicines
9945:
9935:
9903:(1): 41–51.
9900:
9896:
9886:
9851:
9847:
9837:
9828:
9818:
9809:
9799:
9754:
9748:
9715:
9711:
9705:
9670:
9666:
9656:
9621:
9617:
9607:
9574:
9570:
9516:
9512:
9502:
9490:. Retrieved
9486:
9477:
9468:
9458:
9423:
9419:
9409:
9400:
9391:
9382:
9373:
9364:
9355:
9346:
9337:
9302:
9298:
9288:
9251:
9247:
9237:
9202:
9198:
9188:
9155:
9151:
9145:
9136:
9127:
9094:
9090:
9084:
9075:
9066:
9057:
9048:
9008:(1): 18–26.
9005:
9001:
8991:
8958:
8954:
8944:
8911:
8907:
8897:
8855:(1): 11–21.
8852:
8848:
8790:
8786:
8776:
8731:
8727:
8717:
8666:
8662:
8652:
8625:
8621:
8611:
8576:
8572:
8562:
8527:
8523:
8513:
8478:
8474:
8464:
8429:
8425:
8415:
8380:
8376:
8366:
8331:
8327:
8317:
8292:
8288:
8282:
8247:
8243:
8233:
8201:(2): 81–99.
8198:
8194:
8184:
8157:
8153:
8143:
8110:
8106:
8100:
8073:
8069:
8059:
8018:
8014:
8004:
7977:
7973:
7963:
7922:
7918:
7908:
7865:
7862:FEBS Letters
7861:
7851:
7808:
7804:
7794:
7751:
7747:
7737:
7707:(6): 563–7.
7704:
7700:
7694:
7670:(1): 151–7.
7667:
7663:
7653:
7610:
7607:FEBS Letters
7606:
7596:
7555:
7551:
7545:
7502:
7498:
7488:
7445:
7441:
7431:
7399:(5): 880–9.
7396:
7392:
7382:
7349:
7345:
7339:
7294:
7290:
7280:
7245:
7241:
7231:
7196:
7192:
7182:
7157:
7153:
7147:
7112:
7108:
7098:
7063:
7059:
7049:
7014:
7010:
7000:
6963:
6959:
6949:
6904:
6900:
6890:
6878:. Retrieved
6871:the original
6834:
6830:
6817:
6774:
6770:
6760:
6715:
6711:
6701:
6676:
6672:
6666:
6641:
6637:
6631:
6586:
6582:
6572:
6529:
6525:
6515:
6478:
6474:
6424:
6420:
6410:
6373:
6369:
6359:
6327:(1): 13–21.
6324:
6320:
6272:
6268:
6258:
6234:(3): 235–8.
6231:
6227:
6217:
6182:
6178:
6168:
6133:
6129:
6119:
6077:(1): 152–7.
6074:
6070:
6060:
6033:
6029:
6019:
5974:
5970:
5960:
5927:
5923:
5917:
5874:
5870:
5860:
5819:
5815:
5809:
5766:
5762:
5752:
5719:
5715:
5709:
5661:
5655:
5645:
5612:
5608:
5602:
5578:(3): 242–5.
5575:
5571:
5561:
5531:(6): 633–6.
5528:
5524:
5518:
5486:(1): 38–44.
5483:
5479:
5469:
5436:
5432:
5426:
5383:
5379:
5369:
5328:
5324:
5318:
5286:(5): 530–5.
5283:
5279:
5269:
5242:
5238:
5228:
5195:
5191:
5147:
5144:EMBO Reports
5143:
5133:
5112:
5074:
5070:
5060:
5019:
5015:
5009:
4975:(4): 231–9.
4972:
4968:
4958:
4921:
4917:
4907:
4870:
4866:
4856:
4822:(5): 30–46.
4819:
4815:
4805:
4770:
4766:
4756:
4713:
4709:
4699:
4658:
4654:
4648:
4607:
4603:
4597:
4562:
4558:
4536:
4512:(1): 69–81.
4509:
4505:
4495:
4460:
4456:
4446:
4421:
4417:
4411:
4376:
4372:
4362:
4321:
4317:
4311:
4276:
4270:
4245:
4241:
4208:10.2741/2364
4199:
4195:
4185:
4171:{{
4163:{{
4156:
4154:,
4100:
4096:
4046:
4042:
4000:
3996:
3952:
3948:
3896:
3890:
3849:
3845:
3839:
3804:
3800:
3790:
3755:
3751:
3703:
3699:
3643:
3639:
3601:
3597:
3570:(1): 25–33.
3567:
3563:
3519:
3515:
3509:
3461:
3457:
3451:
3408:
3404:
3398:
3386:. Retrieved
3382:the original
3377:
3372:Daneholt B.
3319:
3315:
3309:
3274:
3270:
3226:
3222:
3166:
3162:
3152:
3117:
3111:
3101:
3030:
3026:solid tumors
2991:
2977:
2969:
2965:
2950:
2936:
2932:
2925:
2920:
2914:
2907:pigmentation
2875:
2826:
2798:
2781:
2766:
2742:
2738:
2735:G. morsitans
2734:
2724:
2723:and four of
2720:
2714:
2708:
2707:two each of
2702:
2696:
2693:M. domestica
2692:
2686:
2680:
2670:
2664:
2658:
2657:of insects.
2648:
2642:
2636:
2630:
2624:
2618:
2612:
2606:
2605:
2598:
2591:
2588:Insecticides
2571:
2570:provided by
2532:antioxidants
2521:
2498:
2489:
2485:
2481:
2460:Amyloid beta
2453:
2444:
2440:
2423:chemotherapy
2420:
2379:
2367:
2354:hypertension
2338:
2322:heterozygous
2295:
2276:
2260:
2237:
2228:
2218:NCT01872065
2192:NCT01814839
2166:NCT01780077
2114:NCT01739244
2099:Naked siRNA
2088:NCT01776658
2073:Naked siRNA
2062:NCT00306904
2059:Opko Health
2047:Naked siRNA
2041:Bevasiranib
2036:NCT01676259
2010:NCT01445899
1995:Naked siRNA
1984:NCT00802347
1961:NCT00554359
1946:Naked siRNA
1935:NCT01064505
1920:Naked siRNA
1909:NCT00395057
1894:Naked siRNA
1883:NCT00716014
1868:Naked siRNA
1857:NCT00689065
1831:NCT01617967
1805:NCT01437059
1779:NCT00927459
1753:NCT00658086
1738:Naked siRNA
1727:NCT01518881
1701:NCT01262235
1675:NCT00938574
1649:NCT01591356
1623:NCT01158079
1569:
1554:
1539:
1525:
1481:
1462:
1458:
1434:
1418:
1402:
1387:transfection
1359:
1340:
1336:
1329:
1312:
1304:Applications
1291:
1272:PIWI protein
1259:phylogenetic
1253:
1213:
1209:
1183:
1170:herpes virus
1167:
1163:
1158:
1146:
1144:
1116:
1106:
1088:
1080:
1048:
1022:
1019:S. castellii
1018:
1012:
1006:
1000:
987:
981:
975:
949:
945:
943:
909:
888:The type of
887:
855:
832:
828:chromodomain
801:
753:
696:
685:
673:
669:
666:guide strand
665:
647:
629:
623:
611:
553:
551:
540:
539:and R2D2 in
534:
532:
523:
516:
512:
494:
487:
476:(3′UTRs) of
472:
455:, miRNA and
452:
446:
436:
404:
397:cell nucleus
392:
359:
346:
299:
297:
290:
289:and R2D2 in
284:
282:
267:
241:ribonuclease
238:
207:
195:
176:insecticides
160:cell culture
157:
126:
104:(miRNA) and
95:
80:
60:
59:(PTGS), and
56:
52:
36:
32:
31:
18:
13406:GLP-1 Drugs
13295:Higgs boson
13215:Dark energy
12081:(5): e133.
11780:: 293–311.
11714:: 573–589.
10760:(1): 1–12.
10702:(1): 84–9.
9254:: 201–214.
8872:2445/138257
8334:(9): e366.
8160:(1): 1–12.
8076:(1): 3–16.
7011:Virus Genes
4540:miRBase.org
4202:: 3975–82.
3035:) in 2018.
2998:Hepatitis C
2962:Andrew Fire
2928:virologists
2891:Netherlands
2817:microarrays
2614:Bombyx mori
2601:Lepidoptera
2594:insecticide
2395:hepatitis B
2391:hepatitis A
2350:amyloidosis
2327:(HeFH) and
2212:Recruiting
2186:Recruiting
2160:Recruiting
2134:Recruiting
2108:Recruiting
2082:Recruiting
2030:Recruiting
1978:Recruiting
1903:Terminated
1825:Recruiting
1773:Terminated
1758:PRO-040201
1721:Recruiting
1706:TKM–100201
1695:Recruiting
1680:TKM–080301
1643:Recruiting
1597:Identifier
1559:, Dicerna,
1504:orphan drug
1409:Medications
1284:crown group
1215:Arabidopsis
1130:plants via
1056:orthologous
1027:ascomycetes
962:methylation
890:RNA editing
796:translation
794:to prevent
774:The enzyme
756:translation
680:-dependent
634:PIWI domain
391:known as a
377:development
365:genomically
274:translation
149:Argonaute 2
122:transposons
65:Andrew Fire
13424:Categories
13364:black hole
13085:RNAi tools
13079:GenomeRNAi
12670:30 October
9492:11 January
9133:"Givlaari"
8692:1874/15573
8659:Bernards R
8295:(1): 2–4.
6880:4 December
6185:: 817–46.
5572:Cell Cycle
4559:Genome Res
4379:: bau103.
3388:25 January
3093:References
3045:Inclisiran
3024:to target
3002:transgenic
2970:C. elegans
2897:colors in
2883:transgenic
2870:transgenes
2836:microarray
2784:irrigation
2669:genes and
2626:Spodoptera
2608:Drosophila
2568:resistance
2544:aflatoxins
2342:hemophilia
2335:Conjugates
2318:inclisiran
2171:ALN–TTRsc
2093:SYL040012
2056:Completed
2033:Silenseed
1955:Completed
1929:Completed
1888:AGN211745
1877:Completed
1810:ALN–TTR02
1799:Completed
1784:ALN–PCS02
1747:Completed
1732:ALN–RSV01
1669:Completed
1617:Completed
1602:ALN–VSP02
1542:vutrisiran
1514:(ALA) and
1454:vutrisiran
1450:inclisiran
1420:Drosophila
1399:lentiviral
1366:interferon
1351:algorithms
1337:C. elegans
1267:eukaryotes
1236:cell cycle
1210:C. elegans
1202:stem cells
1190:intergenic
1159:C. elegans
1147:Drosophila
950:Drosophila
946:C. elegans
910:C. elegans
843:centromere
554:C. elegans
542:Drosophila
536:C. elegans
453:C. elegans
448:Drosophila
300:C. elegans
292:Drosophila
286:C. elegans
245:base pairs
145:nucleotide
129:eukaryotes
114:nucleotide
26:Lentiviral
13297:discovery
13236:in action
13234:Evolution
13179:Stem cell
12738:Hannon GJ
12075:PLOS Biol
11820:204702574
11794:0066-4170
11728:2327-056X
11607:: 57–68.
11470:227181536
11454:0031-949X
11104:: 77–96.
10027:219586624
9952:(4): 45.
9712:Pharm Res
9535:2296-858X
9450:232482623
9401:Daily Med
9347:Daily Med
9180:208791867
9119:219592948
9058:Daily Med
9032:1744-2818
8975:1533-4406
8928:0028-4793
8889:205102839
8113:: 19–53.
4457:Genes Dev
4173:retracted
4165:retracted
3552:205215974
3413:CiteSeerX
3041:lumasiran
3037:Givosiran
3033:patisiran
3000:virus in
2879:antisense
2866:wild-type
2552:rapeseeds
2524:allergens
2509:terpenoid
2436:migration
2331:(ASCVD).
2283:Persomics
2111:Sylentis
2085:Sylentis
1914:QPI-1007
1906:Allergan
1836:CALAA-01
1527:Lumasiran
1492:givosiran
1484:givosiran
1464:Patisiran
1446:lumasiran
1442:givosiran
1438:patisiran
1274:, and an
1254:Based on
1250:Evolution
1240:oncogenes
894:adenosine
837:disrupts
729:magnesium
711:conserved
638:Argonaute
616:Argonaute
584:small RNA
504:sequences
413:RNase III
405:pre-miRNA
401:stem-loop
393:pri-miRNA
361:MicroRNAs
341:of a pre-
336:stem-loop
230:stem-loop
222:cytoplasm
218:Argonaute
141:molecules
13362:2019: A
13343:GW170817
13286:HPTN 052
13088:Archived
13064:NY Times
13044:Archived
12986:Novartis
12968:20305636
12922:Alabi CA
12918:Davis ME
12904:16815477
12884:Life Sci
12869:25034627
12861:14585643
12826:16424918
12770:12097900
12715:11373684
12591:12917676
12583:16816104
12457:18610513
12363:43229760
12258:31234985
12215:12354959
12166:16593734
12107:15138502
11988:15708535
11939:16594612
11898:16153609
11863:11030533
11855:16025102
11812:31610134
11744:38499958
11736:27741406
11680:21078327
11623:27436086
11582:23133513
11542:PLOS ONE
11519:25802407
11462:33245254
11399:23733295
11391:23322250
11356:45212581
11348:22861122
11305:29541880
11261:21588259
11253:15107863
11218:17177799
11177:17110445
11126:28803811
11118:22432611
11058:21459775
11009:15811941
10950:16319945
10909:20962218
10860:19532137
10803:16136043
10718:15472715
10677:12536201
10636:15267222
10601:15080188
10560:25380780
10530:Database
10511:16402679
10484:30577479
10458:(1): 6.
10426:23062009
10390:25598342
10355:86214047
10347:16405000
10312:34511611
10304:16900331
10263:16699041
10214:12203116
10192:Oncogene
10173:15195925
10146:20399824
10107:20331529
10066:16466822
10019:32521132
9978:28792479
9927:27959715
9878:33378609
9791:25409604
9732:17252188
9697:30838421
9648:26281785
9599:24150415
9553:36325384
9442:33789010
9379:"Oxlumo"
9329:25446301
9280:26366103
9229:29915990
9172:20226990
9111:32521139
9040:35875890
8983:33789010
8936:32521132
8881:29972753
8827:15240889
8768:15123829
8709:18460980
8701:11910072
8644:16154556
8603:16611941
8554:16845046
8505:15215364
8456:15215362
8407:15980542
8358:27673562
8309:12480342
8274:11917006
8225:16691418
8176:16989803
8135:13010154
8127:16669754
8092:16325172
8043:12931144
7955:43395657
7947:12869753
7900:16154568
7843:24115437
7786:24115438
7729:23467688
7721:16715068
7686:16364746
7664:Virology
7645:16563388
7580:16107852
7537:16107851
7480:16556799
7423:32439482
7415:16611236
7374:33972766
7366:16772641
7331:17071740
7272:16731914
7223:10747034
7174:11485817
7090:17090584
7041:16732482
6992:16545108
6941:16549791
6867:22639035
6859:16786437
6809:19745116
6752:11016957
6693:12742588
6658:14698430
6623:16287976
6564:16789197
6556:11378384
6507:16409629
6481:(1): 3.
6451:17139332
6402:15556947
6351:16369484
6299:15272117
6250:10847677
6209:12045112
6160:16705157
6111:15615848
6052:15475954
6011:17085592
5952:23813417
5944:12733640
5901:12193640
5852:42997104
5844:16931764
5801:14704433
5744:29910065
5736:16825762
5686:10749213
5652:Hannon G
5637:36630239
5629:16284622
5594:16418578
5545:15908945
5510:15574516
5461:41117614
5453:16138829
5418:15800629
5361:31558409
5353:15550672
5310:16527750
5261:14567917
5220:12400060
5212:15170178
5174:16439995
5093:16271387
5052:41436233
5044:14512631
5001:25636176
4950:22539927
4899:24653674
4848:25987950
4797:21931505
4748:18668037
4683:18668040
4632:15685193
4589:18955434
4528:15066283
4487:15231716
4438:17197185
4403:25380780
4373:Database
4354:25287167
4346:15118162
4303:16957365
4262:17350266
4234:23014413
4226:17485351
4152:33214285
4125:17158288
4079:46620298
4071:17124291
4025:46285020
4017:17218517
3979:16603715
3923:26662984
3882:42526536
3874:12016304
3831:26257286
3782:27184117
3730:15800213
3678:19158789
3628:15811921
3586:10778853
3544:19158785
3486:11201747
3435:15614608
3352:23785494
3344:16410517
3301:23950525
3245:16271386
3193:10228554
3184:11146801
3144:24402564
3051:See also
2964:'s 1998
2899:petunias
2889:and the
2860:Example
2788:vascular
2739:A. pisum
2685:has two
2679:pathway
2663:has two
2576:against
2513:gossypol
2511:product
2428:oncogene
2360:(NASH).
2310:BioNtech
2264:plasmids
2197:ARC-520
2145:RXi-109
2140:Unknown
2067:SYL1001
1594:Company
1585:Disease
1456:(2022).
1448:(2020),
1444:(2019),
1440:(2018),
1342:S. pombe
1300:system.
1186:intronic
1140:bacteria
1132:grafting
1123:homologs
1103:Immunity
1091:May 2020
1035:lineages
980:such as
978:protozoa
921:microRNA
847:anaphase
834:S. pombe
808:histones
784:microRNA
760:P-bodies
744:tyrosine
736:stacking
733:aromatic
722:divalent
716:surface
686:in vitro
682:helicase
622:species
576:(RdRP).
367:encoded
356:MicroRNA
343:microRNA
326:MicroRNA
322:(RdRP).
255:. These
172:medicine
139:(dsRNA)
102:microRNA
77:nematode
61:quelling
13386:brings
13313:Rosetta
13145:journal
13141:Science
13130:Science
13061:, from
13016:, from
13005:, from
12959:2855406
12938:Bibcode
12778:4361399
12750:Bibcode
12695:Bibcode
12646:4355692
12638:9486653
12618:Bibcode
12539:9267028
12498:7758115
12437:Science
12422:7878039
12390:Bibcode
12343:Bibcode
12281:Plant J
12250:1484489
12134:Bibcode
11996:9934291
11803:9939233
11650:Bibcode
11573:3484993
11550:Bibcode
11510:4408792
11313:3918937
11285:Bibcode
11168:1838705
11049:3095054
10977:Bibcode
10900:3003593
10851:2835271
10811:6978101
10551:4224276
10475:6351902
10254:1472172
9969:5618303
9918:5778873
9869:7787219
9782:7149983
9740:9995555
9688:6486631
9639:4756474
9579:Bibcode
9544:9618588
9320:4339446
9271:4562648
9220:6132435
9199:Patient
9002:Amyloid
8795:Bibcode
8736:Bibcode
8671:Bibcode
8663:Science
8594:1464853
8545:1538817
8398:1160180
8349:5056990
8216:2583075
8023:Bibcode
7996:8252621
7927:Bibcode
7919:Science
7891:1350842
7870:Bibcode
7834:3875315
7813:Bibcode
7805:Science
7777:3853215
7756:Bibcode
7748:Science
7636:7094296
7615:Bibcode
7588:4431035
7560:Bibcode
7528:1388260
7507:Bibcode
7471:1509097
7450:Bibcode
7442:Science
7322:1693862
7299:Bibcode
7263:1472586
7139:9303318
7130:1170100
7081:1669714
7032:7088519
6983:1462988
6932:1458760
6909:Bibcode
6839:Bibcode
6800:3786161
6779:Bibcode
6771:Science
6720:Bibcode
6614:1287990
6591:Bibcode
6534:Bibcode
6498:1363733
6442:2953463
6393:2947832
6342:2950615
6290:1370607
6200:1823043
6151:1489094
6079:Bibcode
6002:1859931
5979:Bibcode
5909:2613813
5879:Bibcode
5871:Science
5824:Bibcode
5816:Science
5792:3244756
5771:Bibcode
5763:Science
5694:9091863
5666:Bibcode
5553:6085169
5501:1370689
5409:4694588
5388:Bibcode
5333:Bibcode
5325:Science
5288:Bibcode
5165:1456892
5024:Bibcode
5016:Science
4941:3336189
4890:3949217
4839:4434036
4788:3168173
4739:2745094
4718:Bibcode
4691:4429008
4663:Bibcode
4640:4430576
4612:Bibcode
4580:2612969
4394:4224276
4326:Bibcode
4318:Science
4217:2851543
4133:9483460
4105:Bibcode
4097:Science
4051:Bibcode
4043:Science
3997:Science
3970:1440910
3854:Bibcode
3846:Science
3822:4560963
3773:5084781
3721:1072799
3669:2702667
3648:Bibcode
3619:1370754
3524:Bibcode
3494:4371481
3466:Bibcode
3443:2966105
3324:Bibcode
3316:Science
3279:Bibcode
3271:Science
3201:9448271
3122:Bibcode
2862:petunia
2847:History
2778:Topical
2620:Locusta
2556:amylose
2426:(i.e.,
2302:BNT162b
2298:Moderna
2122:CTNNB1
2119:CEQ508
2004:Active
1891:VEGFR1
1851:Active
1689:Cancer
1654:Atu027
1591:Status
1579:Target
1391:plasmid
1389:with a
1378:embryos
1374:oocytes
1288:exosome
1265:of all
1081:updated
898:inosine
878:mammals
849:during
804:genomes
731:and by
620:archaea
497:miRBase
407:by the
234:nucleus
197:Giardia
162:and in
118:viruses
13404:2023:
13395:2022:
13390:to all
13382:2021:
13373:2020:
13354:2018:
13341:2017:
13329:2016:
13321:2015:
13310:2014:
13302:2013:
13293:2012:
13284:2011:
13266:2009:
13258:2008:
13250:2007:
13241:2006:
13232:2005:
13224:Spirit
13221:2004:
13213:2003:
13205:2002:
13193:2001:
13185:2000:
13177:1999:
13169:1998:
13161:1997:
13152:1996:
13019:Nature
12966:
12956:
12930:Nature
12902:
12867:
12859:
12841:Lancet
12824:
12776:
12768:
12742:Nature
12723:710341
12721:
12713:
12687:Nature
12644:
12636:
12610:Nature
12589:
12581:
12537:
12496:
12455:
12420:
12410:
12361:
12335:Nature
12316:
12256:
12248:
12213:
12206:159885
12203:
12164:
12157:386288
12154:
12105:
12098:406394
12095:
12052:
12025:
11994:
11986:
11937:
11927:
11896:
11861:
11853:
11818:
11810:
11800:
11792:
11742:
11734:
11726:
11678:
11621:
11580:
11570:
11517:
11507:
11468:
11460:
11452:
11397:
11389:
11354:
11346:
11311:
11303:
11277:Planta
11259:
11251:
11216:
11175:
11165:
11124:
11116:
11056:
11046:
11007:
11000:556303
10997:
10948:
10907:
10897:
10858:
10848:
10809:
10801:
10716:
10675:
10634:
10599:
10558:
10548:
10509:
10482:
10472:
10424:
10388:
10353:
10345:
10310:
10302:
10261:
10251:
10212:
10171:
10144:
10105:
10064:
10025:
10017:
9976:
9966:
9925:
9915:
9876:
9866:
9810:Forbes
9789:
9779:
9769:
9738:
9730:
9695:
9685:
9646:
9636:
9597:
9551:
9541:
9533:
9448:
9440:
9327:
9317:
9278:
9268:
9227:
9217:
9178:
9170:
9152:Lancet
9117:
9109:
9038:
9030:
8981:
8973:
8934:
8926:
8887:
8879:
8825:
8818:478580
8815:
8766:
8759:409921
8756:
8707:
8699:
8642:
8601:
8591:
8552:
8542:
8503:
8496:441580
8493:
8454:
8447:441546
8444:
8405:
8395:
8356:
8346:
8307:
8272:
8265:101826
8262:
8223:
8213:
8174:
8133:
8125:
8090:
8051:992057
8049:
8041:
8015:Nature
7994:
7953:
7945:
7898:
7888:
7841:
7831:
7784:
7774:
7727:
7719:
7684:
7643:
7633:
7586:
7578:
7552:Nature
7535:
7525:
7499:Nature
7478:
7468:
7421:
7413:
7372:
7364:
7329:
7319:
7270:
7260:
7221:
7214:310235
7211:
7172:
7137:
7127:
7088:
7078:
7039:
7029:
6990:
6980:
6939:
6929:
6865:
6857:
6807:
6797:
6750:
6740:
6691:
6656:
6621:
6611:
6562:
6554:
6505:
6495:
6449:
6439:
6400:
6390:
6349:
6339:
6297:
6287:
6248:
6207:
6197:
6158:
6148:
6109:
6102:544066
6099:
6050:
6009:
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5950:
5942:
5907:
5899:
5850:
5842:
5799:
5789:
5742:
5734:
5692:
5684:
5657:Nature
5635:
5627:
5592:
5551:
5543:
5508:
5498:
5459:
5451:
5416:
5406:
5380:Nature
5359:
5351:
5308:
5259:
5218:
5210:
5172:
5162:
5121:
5091:
5050:
5042:
4999:
4948:
4938:
4924:: 39.
4897:
4887:
4873:: 75.
4846:
4836:
4795:
4785:
4746:
4736:
4710:Nature
4689:
4681:
4655:Nature
4638:
4630:
4604:Nature
4587:
4577:
4526:
4485:
4478:478188
4475:
4436:
4401:
4391:
4352:
4344:
4301:
4291:
4260:
4232:
4224:
4214:
4150:
4146:,
4131:
4123:
4077:
4069:
4023:
4015:
3977:
3967:
3921:
3911:
3880:
3872:
3829:
3819:
3780:
3770:
3728:
3718:
3676:
3666:
3640:Nature
3626:
3616:
3584:
3550:
3542:
3516:Nature
3492:
3484:
3458:Nature
3441:
3433:
3415:
3350:
3342:
3299:
3243:
3199:
3191:
3181:
3142:
3113:Planta
3006:cancer
2966:Nature
2912:fungus
2895:flower
2647:, and
2629:spp.,
2623:spp.,
2611:spp.,
2548:onions
2528:tomato
2501:Cotton
2417:Cancer
2306:Pfizer
2300:. and
2287:Sanofi
2268:CRISPR
2131:I, II
2096:ADRB2
2079:I, II
2070:TRPV1
1975:I, II
1917:CASP2
1862:TD101
1787:PCSK9
1631:EphA2
1588:Phase
1395:siRNAs
1355:siRNAs
1347:siRNAs
1232:tumors
1136:siRNAs
1039:niches
954:siRNAs
906:siRNAs
873:siRNAs
862:siRNAs
725:cation
718:pocket
703:domain
691:5′ end
636:of an
630:Right:
570:siRNAs
566:siRNAs
562:siRNAs
558:siRNAs
547:siRNAs
482:miRNAs
443:siRNAs
438:siRNAs
417:Drosha
381:siRNAs
316:siRNAs
312:siRNAs
308:siRNAs
304:siRNAs
270:siRNAs
257:siRNAs
253:siRNAs
13399:debut
13245:proof
13226:rover
12865:S2CID
12774:S2CID
12719:S2CID
12642:S2CID
12587:S2CID
12413:42583
12359:S2CID
12254:S2CID
11992:S2CID
11859:S2CID
11816:S2CID
11776:(1).
11740:S2CID
11710:(1).
11698:(PDF)
11466:S2CID
11426:(6).
11395:S2CID
11352:S2CID
11309:S2CID
11257:S2CID
11122:S2CID
10807:S2CID
10351:S2CID
10308:S2CID
10023:S2CID
9736:S2CID
9446:S2CID
9176:S2CID
9115:S2CID
8885:S2CID
8705:S2CID
8131:S2CID
8047:S2CID
7951:S2CID
7725:S2CID
7584:S2CID
7419:S2CID
7370:S2CID
6966:: 7.
6874:(PDF)
6863:S2CID
6827:(PDF)
6743:17198
6560:S2CID
5948:S2CID
5905:S2CID
5848:S2CID
5740:S2CID
5690:S2CID
5633:S2CID
5549:S2CID
5457:S2CID
5357:S2CID
5216:S2CID
5048:S2CID
4687:S2CID
4636:S2CID
4350:S2CID
4230:S2CID
4169:with
4129:S2CID
4075:S2CID
4021:S2CID
3878:S2CID
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