Knowledge

Raymond St. Leger

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potential". For example, engineering a mosquito pathogenic fungus to carry a gene for a human anti-malarial antibody so that the fungus targets the malarial parasite in the mosquito reduces the possibility of mosquitoes evolving resistance to the fungus.
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Gao, Q; Ying, S.H; Zhang, Y; Xiao, G; Shang, Y; Duan, Z; Hu, X; Xue-Qin, X; Zhou, G; Peng, G; Luo, Z; Huang, W; Wang, B; Fang, W; Wang, S; Zhong, Y; Ma, L; St. Leger, R.J.; Zhao, G.; Pei, Y; Feng, M.G.; Xia, Y; Wang, C (2011).
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responses. These investigations have also addressed the mechanisms by which new pathogens emerge with different host ranges and genetic variation between individuals in host defenses. Other interests include fungal and insect
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Lovett, B; St. Leger, R.J (2017). Heitman, Joseph; Howlett, Barbara J; Crous, Pedro W; Stukenbrock, Eva H; James, Timothy Y; Gow, Neil A. R (eds.). "The Insect Pathogens".
291:. St. Leger has tested an array of "alternative engineering strategies to be consistent with the highly exploratory approach required for optimizing a pathogens 1927: 1573:
Lovett, B; Bilgo, E; Diabate, A; St. Leger, R.J. (2019). "A review of progress toward field application of transgenic mosquitocidal entomopathogenic fungi".
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in 2019. St. Leger gave the Founders lecture at the 2009 Society of Invertebrate Pathology Meeting honoring his friend and frequent collaborator
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Promega Biotechnology Research Award (2017) and was the inaugural recipient of the Tai Fung-Lan Award for International Cooperation from The
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Lovett, B; Bilgo, E; Millogo, S.A; Ouattarra, A.K; Sare, I; Gnambani, E.J; Dabire, R.K; Diabate, A; St.Leger, R.J. (2019).
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National Research Council (2009). "Emerging Technologies to Benefit Farmers in Sub-Saharan Africa and South Asia".
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Fang, W; St. Leger, R.J (2010). "RNA binding proteins mediate the ability of a fungus to adapt to the cold".
304: 514:(2012). "Strain improvement of fungal insecticides for controlling insect pests and vector-borne diseases". 1347:
produces indole-3-acetic acid, which promotes root growth in Arabidopsis and enhances virulence to insects"
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St. Leger is an advocate of online open education and since 2013 has co-taught with Dr. Tammatha O’Brien (
477: 312: 1484: 802:"Alternative transcription start site selection in Mr-OPY2 controls lifestyle transitions in the fungus 486: 343: 323:. St. Leger has also served on many national and international policy-making committees including the 287:
has shown that these engineered pathogens have the potential to control insect borne diseases such as
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platform called Genes and the Human Condition that has had more than 200,000 active learners.
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perilipin homolog MPL1 regulates lipid metabolism, appressorial turgor pressure and virulence"
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Fang, W; Vega-Rodriguez, J; Ghosh, A.K; Jacobs-Lorena, M; Khang, A; St. Leger, R.J. (2011).
1189:"A phylogenomic approach to reconstructing the diversification of serine proteases in fungi" 1892: 1629: 1527: 1035: 921: 817: 709: 387: 8: 359: 316: 261: 244: 157: 1633: 1531: 1039: 925: 821: 713: 494: 164:
who currently holds the rank of Distinguished University Professor in the Department of
1858: 1849: 1650: 1617: 1598: 1550: 1511: 1412: 1387: 1318: 1289: 1265: 1231:"Genome Sequencing and Comparative Transcriptomics of the Model Entomopathogenic Fungi 1230: 1164: 1133: 1109: 1082: 1058: 1024:"Trajectory and genomic determinants of fungal-pathogen speciation and host adaptation" 1023: 999: 968: 944: 905: 838: 801: 732: 697: 391: 371: 328: 112: 79: 1022:
Hu, X; Zheng, P; Shang, Y; Su, Y; Zhang, X; Zhan, X; St. Leger, R.J.; Wang, C (2014).
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technologies, including altering insect pathogens so that they carry genes encoding
1825: 1779:"UMD-led Study Named Most Impactful Paper Published in the Journal Science in 2019" 1678: 1645: 1637: 1582: 1545: 1535: 1407: 1399: 1358: 1313: 1305: 1260: 1250: 1200: 1159: 1149: 1104: 1094: 1053: 1043: 994: 984: 939: 929: 878: 833: 825: 772: 727: 717: 670: 625: 529: 490: 379: 200:, he has since then published more than 150 scientific papers and book chapters on 123: 1618:"Development of transgenic fungi that kill human malaria parasites in mosquitoes" 1388:"Construction of a hypervirulent and specific mycoinsecticide for locust control" 1255: 1154: 989: 161: 1821: 829: 197: 1829: 1309: 882: 533: 1886: 1837: 541: 502: 300: 185: 102: 1641: 1540: 1099: 1048: 934: 800:
Guo, N; Zhang, Q; Chen, X; Zhang, X; Xu, C; St. Leger, R.J; Fang, W (2017).
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associations between microbes and plants that can be exploited to benefit
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Zhang, Q; Chen, X; Quo, N; Meng, Y; St. Leger, R.J; Fang, Weiguo (2019).
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Wang, C; Hu, G.; St. Leger, R.J (2005). "Differential gene expression by
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St. Leger has received several awards for his research, he was elected a
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rapidly kills mosquitoes in a malaria-endemic region of Burkina Faso"
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funded National Academies Committee to study technologies to benefit
257: 240: 220: 204: 1615: 1586: 1682: 1437:"GM fungus rapidly kills 99% of malaria mosquitoes, study suggests" 1134:"The genetic basis for variation in resistance to infection in the 525: 347: 280: 253: 232: 99: 475:(1994). "Interactions Between Fungal Pathogens and Insect Hosts". 61: 1485:"Genetically-altered fungus murders mosquitoes with spider venom" 395: 367: 288: 236: 216: 212: 65: 49: 1708:"Genes and the Human Condition (from behavior to Biotechnology)" 969:"Insertion of an esterase gene into a specific locust pathogen ( 1462: 695: 407: 339: 276: 248: 208: 201: 45: 169: 247:, initiate host invasion, colonize tissues, and counter host 228: 1287: 696:
Wang, S; O’Brien, T; Pava-Ripoll, M; St. Leger, R.J (2011).
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Liao, X; Lovett, B; Fang, W; St. Leger, R.J. (2017).
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Liao, X; O'Brien, T; Fang, W; St. Leger, R.J (2014).
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species correlate with their association with roots"
1385: 303:to many private and public concerns, including the 1386:Fang, W; Lu, H; King, G.F; St. Leger, R.J (2015). 967:Wang, S; Fang, W; Wang, C; St. Leger, R.J (2011). 799: 1884: 1705: 1227: 1080: 571: 569: 567: 1131: 1087:Proceedings of the National Academy of Sciences 1028:Proceedings of the National Academy of Sciences 914:Proceedings of the National Academy of Sciences 860: 702:Proceedings of the National Academy of Sciences 615: 260:, molecular biology and genomics of fungi, and 148:(born 1957, in London, England) is an American 1021: 467: 1796: 1750: 1132:Wang, J.B.; Lu, H.L.; St. Leger, R.J (2017). 903: 754: 660: 564: 1928:University of Maryland, College Park faculty 1609: 1503: 1281: 1186: 1566: 450:for the most impactful paper published in 1802: 1649: 1549: 1539: 1434: 1411: 1362: 1317: 1264: 1254: 1204: 1163: 1153: 1108: 1098: 1074: 1057: 1047: 998: 988: 943: 933: 837: 776: 731: 721: 689: 609: 1379: 1334: 1125: 960: 461: 1666: 1221: 906:"A collagenous protective coat enables 897: 854: 748: 654: 438:(2016). St. Leger received an honorary 271:St. Leger is also known for developing 243:in general respond to stress, changing 1908:British emigrants to the United States 1885: 1776: 1753:"Professor Raymond J. St. Leger (DSc)" 1731:"Dr. Raymond J. St. Leger, ESA fellow" 1482: 1298:Applied Microbiology and Biotechnology 1180: 1015: 793: 428:Fellow of the Royal Society of Biology 179: 420:Royal Entomological Society of London 973:) enables it to infect caterpillars" 401: 174:University of Maryland, College Park 510:Fang, Weiguo; Azimzadeh, Philippe; 495:10.1146/annurev.en.39.010194.001453 299:St. Leger has been a consultant on 239:), as models for understanding how 219:, and on the reactions of hosts to 13: 1948:Society for Invertebrate Pathology 1913:Alumni of the University of Exeter 1818:Society for Invertebrate Pathology 865:growing in root exudate and host ( 582:Society for Invertebrate Pathology 14: 1959: 1871: 1809:Journal of Invertebrate Pathology 1290:"The plant beneficial effects of 910:to evade insect immune responses" 432:American Society for Microbiology 223:. St. Leger has principally used 1918:Alumni of the University of Bath 1903:21st-century American biologists 1460: 1435:Gallagher, James (31 May 2019). 1206:10.1111/j.1420-9101.2004.00786.x 904:Wang, C; St. Leger, R.J (2006). 755:Wang, C; St. Leger, R.J (2007). 675:10.1111/j.1462-2920.2009.02127.x 424:Entomological Society of America 416:American Academy of Microbiology 60: 1770: 1744: 1728: 1722: 1699: 1476: 1454: 1428: 1193:Journal of Evolutionary Biology 1187:Hu, G.; St. Leger, R.J (2004). 765:Journal of Biological Chemistry 517:Current Opinion in Microbiology 321:Organization of American States 1: 1777:Cutlip, Kimbra (2020-01-24). 557: 1706:St. Leger, R.J; O'Brien, T. 1675:The National Academies Press 1256:10.1371/journal.pgen.1001264 1155:10.1371/journal.ppat.1006260 990:10.1371/journal.ppat.1002097 436:Mycological Society of China 353: 340:https://tammatha.weebly.com/ 7: 1483:Bonner, Walt (2019-06-10). 871:Fungal Genetics and Biology 478:Annual Review of Entomology 188:to begin his career at the 170:https://entomology.umd.edu/ 10: 1964: 830:10.1038/s41467-017-01756-1 663:Environmental Microbiology 1830:10.1016/j.jip.2010.09.021 1310:10.1007/s00253-014-5788-2 883:10.1016/j.fgb.2005.04.006 534:10.1016/j.mib.2011.12.012 283:toxins. A field trial in 139: 122: 108: 92: 85: 71: 56: 28: 21: 1138:genetic reference panel" 430:(FRSB). He received the 190:Boyce Thompson Institute 1642:10.1126/science.1199115 1575:Pest Management Science 1541:10.1126/science.aaw8737 1136:Drosophila melanogaster 1100:10.1073/pnas.1816430116 1049:10.1073/pnas.1412662111 935:10.1073/pnas.0601951103 723:10.1073/pnas.1113824108 448:Newcomb Cleveland Prize 442:from his alma mater of 358:St. Leger received his 225:entomopathogenic fungus 1938:American entomologists 1923:Scientists from London 1233:Metarhizium anisopliae 908:Metarhizium anisopliae 863:Metarhizium anisopliae 778:10.1074/jbc.M609592200 759:Metarhizium anisopliae 597:Cite journal requires 184:St. Leger went to the 117:University of Maryland 1804:St. Leger, Raymond J. 1345:Metarhizium robertsii 1034:(2014): 16796–16801. 810:Nature Communications 804:Metarhizium robertsii 771:(2007): 21110–21115. 708:(2011): 20449–20454. 630:10.1128/9781555819583 512:St. Leger, Raymond J. 473:St. Leger, Raymond J. 462:Selected bibliography 192:at the invitation of 1933:American mycologists 1364:10.1099/mic.0.000494 388:Doctor of Philosophy 146:Raymond J. St. Leger 16:British entomologist 1783:umdrightnow.umd.edu 1751:Exeter University. 1634:2011Sci...331.1074F 1628:(2011): 1074–1077. 1532:2019Sci...364..894L 1304:(2014): 7089–7096. 1199:(2004): 1204–1214. 1093:(2019): 7982–7989. 1040:2014PNAS..11116796H 971:Metarhizium acridum 926:2006PNAS..103.6647W 920:(2006): 2647–6652. 822:2017NatCo...8.1565G 714:2011PNAS..10820449W 452:the journal Science 422:(FRES) (2011), the 360:Bachelor of Science 317:US State Department 180:Research and career 158:molecular biologist 1392:Scientific Reports 1249:(2011): e1001264. 1148:(2017): e1006260. 983:(2011): e1002097. 618:The Fungal Kingdom 576:"SIP Newsletter". 392:University of Bath 329:Sub Saharan Africa 113:Cornell University 80:University of Bath 1878:The St. Leger Lab 1692:978-0-309-12494-2 1526:(2019): 894–897. 1404:10.1038/srep07345 1357:(2017): 980–991. 877:(2005): 704–718. 669:(2010): 810–820. 456:Donald W. Roberts 446:in 2018 and the 444:Exeter University 402:Awards and honors 390:in 1985 from the 384:London University 372:Master of Science 364:Exeter University 194:Donald W. Roberts 143: 142: 87:Scientific career 76:Exeter University 23:Raymond St. Leger 1955: 1865: 1857: 1800: 1794: 1793: 1791: 1789: 1774: 1768: 1767: 1765: 1763: 1748: 1742: 1741: 1739: 1737: 1726: 1720: 1719: 1717: 1715: 1703: 1697: 1696: 1670: 1664: 1663: 1653: 1613: 1607: 1606: 1581:(9): 2316–2324. 1570: 1564: 1563: 1553: 1543: 1507: 1501: 1500: 1498: 1496: 1480: 1474: 1473: 1471: 1469: 1458: 1452: 1451: 1449: 1447: 1432: 1426: 1425: 1415: 1383: 1377: 1376: 1366: 1338: 1332: 1331: 1321: 1285: 1279: 1278: 1268: 1258: 1225: 1219: 1218: 1208: 1184: 1178: 1177: 1167: 1157: 1129: 1123: 1122: 1112: 1102: 1078: 1072: 1071: 1061: 1051: 1019: 1013: 1012: 1002: 992: 964: 958: 957: 947: 937: 901: 895: 894: 858: 852: 851: 841: 797: 791: 790: 780: 752: 746: 745: 735: 725: 693: 687: 686: 658: 652: 651: 613: 607: 606: 600: 595: 593: 585: 573: 553: 506: 426:(2019) and is a 380:Birkbeck College 362:in biology from 124:Doctoral advisor 64: 42: 38: 36: 19: 18: 1963: 1962: 1958: 1957: 1956: 1954: 1953: 1952: 1943:St Leger family 1883: 1882: 1874: 1869: 1868: 1801: 1797: 1787: 1785: 1775: 1771: 1761: 1759: 1749: 1745: 1735: 1733: 1727: 1723: 1713: 1711: 1704: 1700: 1693: 1671: 1667: 1614: 1610: 1587:10.1002/ps.5385 1571: 1567: 1508: 1504: 1494: 1492: 1481: 1477: 1467: 1465: 1459: 1455: 1445: 1443: 1433: 1429: 1384: 1380: 1339: 1335: 1286: 1282: 1226: 1222: 1185: 1181: 1130: 1126: 1079: 1075: 1020: 1016: 965: 961: 902: 898: 859: 855: 798: 794: 753: 749: 694: 690: 659: 655: 640: 614: 610: 598: 596: 587: 586: 575: 574: 565: 560: 464: 404: 356: 196:. According to 182: 162:biotechnologist 115: 78: 72:Alma mater 52: 43: 40: 34: 32: 24: 17: 12: 11: 5: 1961: 1951: 1950: 1945: 1940: 1935: 1930: 1925: 1920: 1915: 1910: 1905: 1900: 1895: 1881: 1880: 1873: 1872:External links 1870: 1867: 1866: 1822:Academic Press 1795: 1769: 1743: 1721: 1698: 1691: 1683:10.17226/12455 1665: 1608: 1565: 1502: 1475: 1453: 1427: 1398:(2014): 7345. 1378: 1333: 1280: 1220: 1179: 1142:PLOS Pathogens 1124: 1073: 1014: 977:PLOS Pathogens 959: 896: 853: 792: 747: 688: 653: 638: 608: 599:|journal= 562: 561: 559: 556: 555: 554: 507: 487:Annual Reviews 463: 460: 403: 400: 355: 352: 198:Google Scholar 181: 178: 141: 140: 137: 136: 134:Richard Cooper 130:Keith Charnley 126: 120: 119: 110: 106: 105: 94: 90: 89: 83: 82: 73: 69: 68: 58: 54: 53: 44: 30: 26: 25: 22: 15: 9: 6: 4: 3: 2: 1960: 1949: 1946: 1944: 1941: 1939: 1936: 1934: 1931: 1929: 1926: 1924: 1921: 1919: 1916: 1914: 1911: 1909: 1906: 1904: 1901: 1899: 1898:Living people 1896: 1894: 1891: 1890: 1888: 1879: 1876: 1875: 1864: 1860: 1855: 1851: 1847: 1843: 1839: 1835: 1831: 1827: 1823: 1819: 1815: 1811: 1810: 1805: 1799: 1784: 1780: 1773: 1758: 1754: 1747: 1732: 1725: 1709: 1702: 1694: 1688: 1684: 1680: 1676: 1669: 1661: 1657: 1652: 1647: 1643: 1639: 1635: 1631: 1627: 1623: 1619: 1612: 1604: 1600: 1596: 1592: 1588: 1584: 1580: 1576: 1569: 1561: 1557: 1552: 1547: 1542: 1537: 1533: 1529: 1525: 1521: 1517: 1515: 1506: 1490: 1486: 1479: 1464: 1457: 1442: 1438: 1431: 1423: 1419: 1414: 1409: 1405: 1401: 1397: 1393: 1389: 1382: 1374: 1370: 1365: 1360: 1356: 1352: 1348: 1346: 1337: 1329: 1325: 1320: 1315: 1311: 1307: 1303: 1299: 1295: 1293: 1284: 1276: 1272: 1267: 1262: 1257: 1252: 1248: 1244: 1243:PLOS Genetics 1240: 1238: 1234: 1224: 1216: 1212: 1207: 1202: 1198: 1194: 1190: 1183: 1175: 1171: 1166: 1161: 1156: 1151: 1147: 1143: 1139: 1137: 1128: 1120: 1116: 1111: 1106: 1101: 1096: 1092: 1088: 1084: 1077: 1069: 1065: 1060: 1055: 1050: 1045: 1041: 1037: 1033: 1029: 1025: 1018: 1010: 1006: 1001: 996: 991: 986: 982: 978: 974: 972: 963: 955: 951: 946: 941: 936: 931: 927: 923: 919: 915: 911: 909: 900: 892: 888: 884: 880: 876: 872: 868: 867:Manduca sexta 864: 857: 849: 845: 840: 835: 831: 827: 823: 819: 815: 811: 807: 805: 796: 788: 784: 779: 774: 770: 766: 762: 760: 751: 743: 739: 734: 729: 724: 719: 715: 711: 707: 703: 699: 692: 684: 680: 676: 672: 668: 664: 657: 649: 645: 641: 639:9781683670827 635: 631: 627: 623: 619: 612: 604: 591: 583: 579: 572: 570: 568: 563: 551: 547: 543: 539: 535: 531: 527: 523: 519: 518: 513: 508: 504: 500: 496: 492: 488: 484: 480: 479: 474: 470: 469:Hajek, Ann E. 466: 465: 459: 457: 453: 449: 445: 441: 437: 433: 429: 425: 421: 418:(2013), the 417: 413: 409: 399: 397: 393: 389: 385: 381: 378:in 1980 from 377: 373: 369: 365: 361: 351: 349: 345: 341: 336: 334: 330: 326: 322: 318: 314: 310: 306: 302: 301:biotechnology 297: 294: 290: 286: 282: 278: 274: 269: 267: 263: 259: 255: 250: 246: 242: 238: 234: 230: 226: 222: 218: 214: 210: 206: 203: 199: 195: 191: 187: 186:United States 177: 175: 171: 167: 163: 159: 155: 151: 147: 138: 135: 131: 127: 125: 121: 118: 114: 111: 107: 104: 103:Biotechnology 101: 98: 95: 91: 88: 84: 81: 77: 74: 70: 67: 63: 59: 55: 51: 47: 41:(age 67) 39:April 1, 1957 31: 27: 20: 1824:): 211–219. 1813: 1807: 1803: 1798: 1786:. Retrieved 1782: 1772: 1760:. Retrieved 1757:Exeter.ac.uk 1756: 1746: 1734:. Retrieved 1724: 1712:. Retrieved 1701: 1674: 1668: 1625: 1621: 1611: 1578: 1574: 1568: 1523: 1519: 1513: 1512:"Transgenic 1505: 1493:. Retrieved 1488: 1478: 1466:. Retrieved 1461:Saey, Tina. 1456: 1444:. Retrieved 1440: 1430: 1395: 1391: 1381: 1354: 1351:Microbiology 1350: 1344: 1336: 1301: 1297: 1291: 1283: 1246: 1242: 1236: 1232: 1223: 1196: 1192: 1182: 1145: 1141: 1135: 1127: 1090: 1086: 1076: 1031: 1027: 1017: 980: 976: 970: 962: 917: 913: 907: 899: 874: 870: 866: 862: 856: 813: 809: 803: 795: 768: 764: 758: 750: 705: 701: 691: 666: 662: 656: 621: 617: 611: 590:cite journal 584:. June 2009. 577: 521: 515: 511: 482: 476: 472: 414:(2012), the 405: 357: 337: 298: 285:Burkina Faso 270: 245:environments 231:that act as 183: 154:entomologist 145: 144: 109:Institutions 86: 1893:1957 births 1514:Metarhizium 1489:foxnews.com 1292:Metarhizium 816:(1): 1565. 528:: 232–238. 489:: 293–322. 370:in 1978, a 266:agriculture 262:mutualistic 128:Professors 57:Nationality 1887:Categories 1788:7 February 1762:7 February 1736:7 February 1714:7 February 1710:. Coursera 1491:. 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Index

London
England

England
Exeter University
University of Bath
Entomology
Mycology
Biotechnology
Cornell University
University of Maryland
Doctoral advisor
Keith Charnley
Richard Cooper
mycologist
entomologist
molecular biologist
biotechnologist
Entomology
https://entomology.umd.edu/
University of Maryland, College Park
United States
Boyce Thompson Institute
Donald W. Roberts
Google Scholar
fungal
pathogens
plants
animals
insects

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