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Regenerative medicine

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200:) had the potential to develop into a new kind of regenerative therapy. Explaining the new class of therapies that such cells could enable, he used the term "regenerative medicine" in the way that it is used today: "an approach to therapy that ... employs human genes, proteins and cells to re-grow, restore or provide mechanical replacements for tissues that have been injured by trauma, damaged by disease or worn by time" and "offers the prospect of curing diseases that cannot be treated effectively today, including those related to aging". 204:
stem cell therapies, gene therapy, tissue engineering, genomic medicine, personalized medicine, biomechanical prosthetics, recombinant proteins, and antibody treatments. It also includes more familiar chemical pharmacopeia—in short, any intervention that restores a person to normal health. In addition to functioning as shorthand for a wide range of technologies and treatments, the term "regenerative medicine" is also patient friendly. It solves the problem that confusing or intimidating language discourages patients.
261:, using an adaptive method originally devised for treating osteoarthritis. The team then seeded the newly grown chondrocytes, as well as epithelial cells, into a decellularised (free of donor cells) tracheal segment that was donated from a 51-year-old transplant donor who had died of cerebral hemorrhage. After four days of seeding, the graft was used to replace the patient's left main bronchus. After one month, a biopsy elicited local bleeding, indicating that the blood vessels had already grown back successfully. 350: 3497: 3527: 172:(usually lambs or calves) into his patients in an attempt to rejuvenate them. In 1956, a more sophisticated process was created to treat leukemia by inserting bone marrow from a healthy person into a patient with leukemia. This process worked mostly due to both the donor and receiver in this case being identical twins. Nowadays, bone marrow can be taken from people who are similar enough to the patient who needs the cells to prevent rejection. 3537: 3957: 103: 3517: 31: 3507: 242:. The peer-reviewed journal facilitated discourse around regenerative medicine by publishing innovative research on stem cell therapies, gene therapies, tissue engineering, and biomechanical prosthetics. The Society for Regenerative Medicine, later renamed the Regenerative Medicine and Stem Cell Biology Society, served a similar purpose, creating a community of like-minded experts from around the world. 168:
century further pushed the theory that body parts could regenerate and grow new cells. These advances led to tissue engineering, and from this field, the study of regenerative medicine expanded and began to take hold. This began with cellular therapy, which led to the stem cell research that is widely being conducted today.
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A person's baby teeth are known to contain stem cells that can be used for regeneration of the dental pulp after a root canal treatment or injury. These cells can also be used to repair damage from periodontitis, an advanced form of gum disease that causes bone loss and severe gum recession. Research
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Animal studies conducted on mice in Japan in 2007 show great possibilities in regenerating an entire tooth. Some mice had a tooth extracted and the cells from bioengineered tooth germs were implanted into them and allowed to grow. The result were perfectly functioning and healthy teeth, complete with
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Widespread interest and funding for research on regenerative medicine has prompted institutions in the United States and around the world to establish departments and research institutes that specialize in regenerative medicine including: The Department of Rehabilitation and Regenerative Medicine at
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The term was brought into the popular culture in 1999 by William A. Haseltine when he coined the term during a conference on Lake Como, to describe interventions that restore to normal function that which is damaged by disease, injured by trauma, or worn by time. Haseltine was briefed on the project
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The term "regenerative medicine" was first used in a 1992 article on hospital administration by Leland Kaiser. Kaiser's paper closes with a series of short paragraphs on future technologies that will impact hospitals. One paragraph had "Regenerative Medicine" as a bold print title and stated, "A new
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The ancient Greeks postulated whether parts of the body could be regenerated in the 700s BC. Skin grafting, invented in the late 19th century, can be thought of as the earliest major attempt to recreate bodily tissue to restore structure and function. Advances in transplanting body parts in the 20th
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Later, Haseltine would go on to explain that regenerative medicine acknowledges the reality that most people, regardless of which illness they have or which treatment they require, simply want to be restored to normal health. Designed to be applied broadly, the original definition includes cell and
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deals with the "process of replacing, engineering or regenerating human or animal cells, tissues or organs to restore or establish normal function". This field holds the promise of engineering damaged tissues and organs by stimulating the body's own repair mechanisms to functionally heal previously
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The first cell therapies were intended to slow the aging process. This began in the 1930s with Paul Niehans, a Swiss doctor who was known to have treated famous historical figures such as Pope Pius XII, Charlie Chaplin, and king Ibn Saud of Saudi Arabia. Niehans would inject cells of young animals
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Regenerative medicine has been studied by dentists to find ways that damaged teeth can be repaired and restored to obtain natural structure and function. Dental tissues are often damaged due to tooth decay, and are often deemed to be irreplaceable except by synthetic or metal dental fillings or
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is still being done to see if these stem cells are viable enough to grow into completely new teeth. Some parents even opt to keep their children's baby teeth in special storage with the thought that, when older, the children could use the stem cells within them to treat a condition.
455:, which can differentiate into any type of tissue). Cord blood has been studied as a treatment for diabetes. However, apart from blood disorders, the use of cord blood for other diseases is not a routine clinical modality and remains a major challenge for the stem cell community. 45:
Regenerative medicine also includes the possibility of growing tissues and organs in the laboratory and implanting them when the body cannot heal itself. When the cell source for a regenerated organ is derived from the patient's own tissue or cells, the challenge of organ
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all three layers, as well as roots. These teeth also had the necessary ligaments to stay rooted in its socket and allow for natural shifting. They contrast with traditional dental implants, which are restricted to one spot as they are drilled into the jawbone.
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Dr. Paul Niehans was a former physician of Pope Paul XII, among others. A surgeon who performed more than 50,000 operations in 40 years, he developed his own rejuvenation treatment by injecting humans with the foetus of unborn lambs and other
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The term regenerative medicine is increasingly conflated with research on stem cell therapies. Some academic programs and departments retain the original broader definition while others use it to describe work on stem cell research.
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was launched, with its stated aim as "the application of regenerative medicine – defined to include the repair of living cells and extracellular material in situ – to the diseases and disabilities of ageing". In 2012, Professor
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On September 12, 2014, surgeons at the Institute of Biomedical Research and Innovation Hospital in Kobe, Japan, transplanted a 1.3 by 3.0 millimeter sheet of retinal pigment epithelium cells, which were differentiated from
257:, performed the first tissue engineered trachea (wind pipe) transplantation. Adult stem cells were extracted from the patient's bone marrow, grown into a large population, and matured into cartilage cells, or 443:
beyond blood and immunological disorders is speculative, some research has been done in other areas. Any such potential beyond blood and immunological uses is limited by the fact that cord cells are
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Walther, Mary Margaret (2009). "Chapter 39. Cord Blood Hematopoietic Cell Transplantation". In Appelbaum, Frederick R.; Forman, Stephen J.; Negrin, Robert S.; Blume, Karl G. (eds.).
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that claims to have the ability to regrow dentin, the second layer of the tooth beneath the enamel which encases and protects the pulp (often referred to as the nerve).
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branch of medicine will develop that attempts to change the course of chronic disease and in many instances will regenerate tired and failing organ systems."
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Li, T; Xia, M; Gao, Y; Chen, Y; Xu, Y (2015). "Human umbilical cord mesenchymal stem cells: an overview of their potential in cell-based therapy".
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Haseltine, William A (2011-07-01). "Interview: Commercial translation of cell-based therapies and regenerative medicine: learning by experience".
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via immunological mismatch is circumvented. This approach could alleviate the problem of the shortage of organs available for donation.
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crowns, which requires further damage to be done to the teeth by drilling into them to prevent the loss of an entire tooth.
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and his team improved upon the 2008 implant by transplanting a laboratory-made trachea seeded with the patient's own cells.
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by biologically active molecules administered alone or as a secretion by infused cells (immunomodulation therapy); and
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Hsueh, Ming-Feng; Ă–nnerfjord, Patrik; Bolognesi, Michael P.; Easley, Mark E.; Kraus, Virginia B. (October 2019).
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Muneoka K; Allan CH; Yang X; Lee J; Han M (December 2008). "Mammalian regeneration and regenerative medicine".
220: 3961: 3927: 2389: 495: 2047: 697: 3372: 2002: 1904: 3993: 3016: 2574: 1558:
Cyranoski, David (12 September 2014). "Japanese woman is first recipient of next-generation stem cells".
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Haseltine, WA (6 July 2004). "The Emergence of Regenerative Medicine: A New Field and a New Society".
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that led to the first isolation of human embryonic stem and human embryonic germ cells, respectively.
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Some of the biomedical approaches within the field of regenerative medicine may involve the use of
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Lan, Xiaoyan; Sun, Zhengwu; Chu, Chengyan; Boltze, Johannes; Li, Shen (2 August 2019).
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Steindorff, Marina M.; Lehl, Helena; Winkel, Andreas; Stiesch, Meike (February 2014).
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Riazi AM; Kwon SY; Stanford WL (2009). "Stem Cell Sources for Regenerative Medicine".
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Mason, Chris; Dunnill, Peter (2008). "A brief definition of regenerative medicine".
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in Sweden due to falsified test results and lies. The TV-show Experimenten aired on
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Mason C; Dunnill P (January 2008). "A brief definition of regenerative medicine".
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Cogle CR; Guthrie SM; Sanders RC; Allen WL; Scott EW; Petersen BE (August 2003).
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for the treatment of chronic wounds and burns. In 2021 the FDA gave approval for
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Sampogna, Gianluca; Guraya, Salman Yousuf; Forgione, Atonello (September 2015).
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Saldin, LT; Cramer, MC; Velankar, SS; White, LJ; Badylak, SF (February 2017).
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Sampogna, Gianluca; Guraya, Salman Yousuf; Forgione, Antonello (2015-09-01).
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A diagram of a human tooth. Stem cells are located in the pulp in the center.
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Liberation Biology: The Scientific and Moral Case for the Biotech Revolution
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Placzek, Mark R; Chung, I-Ming; Macedo, Hugo M; et al. (March 2009).
2403: 2123:"Extracellular matrix bioscaffolds in tissue remodeling and morphogenesis" 1122: 3841: 3836: 3769: 3309: 3254: 3151: 3006: 2981: 2799: 1203: 1170: 641:"Stem cells application in regenerative medicine and disease threpeutics" 485: 463: 448: 349: 329:. In China, institutes dedicated to regenerative medicine are run by the 258: 3551: 1694: 850: 833: 3801: 3703: 3397: 3282: 3249: 3021: 2971: 2956: 2951: 2944: 2929: 2919: 2138: 886: 440: 362: 1599:"'Superstar doctor' fired from Swedish institute over research 'lies'" 1463:"Tissue-Engineered Trachea Transplant Is Adult Stem Cell Breakthrough" 1432: 769: 238:, M.D., Michael D. West, Ph.D., and other leading researchers founded 3831: 3470: 3212: 3207: 3071: 3049: 2924: 2888: 2590: 278: 58: 54: 2572: 2332:
Caseiro, AR; Pereira, T; Ivanova, G; LuĂ­s, AL; MaurĂ­cio, AC (2016).
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Thomas' hematopoietic cell transplantation stem cell transplantation
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stem cells (which can differentiate only into blood cells), and not
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Metallo CM; Azarin SM; Ji L; de Pablo JJ; Palecek SP (June 2008).
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Researchers from King's College London have created a drug called
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to isolate human embryonic stem cells and embryonic germ cells at
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to be used in surgical applications including plastic surgery.
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Roura S, Pujal JM, Gálvez-Montón C, Bayes-Genis A (2015).
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Institute for Tissue Engineering and Regenerative Medicine
1365:"Bloomberg Longevity Economy Conference 2013 Panelist Bio" 790: 2575:"An overview of stem cell research and regulatory issues" 2331: 2071: 1948: 1719:"Wake Forest Institute for Regenerative Medicine (WFIRM)" 1109:
Kaiser LR (1992). "The future of multihospital systems".
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Institute for Stem Cell Biologyand Regenerative Medicine
1080:"1956: The First Successful Bone Marrow Transplantation" 1175:
The Emergence of Tissue Engineering as a Research Field
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The use of fish skin with its natural constituent of
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materials are commercially available and are used in
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Stoick-Cooper CL; Moon RT; Weidinger G (June 2007).
285:, into an eye of an elderly woman, who suffers from 192:. He recognized that these cells' unique ability to 2569:, gives more details about Regenerative Stem Cells. 2472: 1177:. Arlington, VA: National Science Foundation, 2003. 2045: 1976:"Japanese scientists grow teeth from single cells" 1135: 321:, the Center for Regenerative and Nanomedicine at 215:, PhD, organized and managed the research between 27:Field of medicine involved in regenerating tissues 1247: 304:and detailed all the lies and falsified results. 3975: 2560: 2120: 1383:"E-Biomed: The Journal of Regenerative Medicine" 720: 117:, potentially preventing the article from being 3692:Strategies for engineered negligible senescence 2618:, vol. 320, no. 4 (April 2019), pp. 56–61. 1843: 2250: 2248: 2022:"Could Baby Teeth Stem Cells Save Your Child?" 1223:E-biomed: The Journal of Regenerative Medicine 240:E-Biomed: The Journal of Regenerative Medicine 3567: 2738: 2278: 2276: 1551: 1214: 1136:Lysaght MJ; Crager J (July 2009). "Origins". 2622: 2435: 2376: 2189: 2187: 1655:: CS1 maint: multiple names: authors list ( 875:Birth Defects Research. Part C, Embryo Today 581: 2245: 1630:Sweden, Sveriges Television AB, Stockholm. 196:into all the cell types of the human body ( 3956: 3574: 3560: 3027:Reproductive endocrinology and infertility 2745: 2731: 2635:Journal of Cellular and Molecular Medicine 2282: 2273: 137:reliable, independent, third-party sources 3581: 3368:Bachelor of Medicine, Bachelor of Surgery 2705: 2654: 2520: 2412: 2402: 2359: 2349: 2308: 2259:(4th ed.). Oxford: Wiley-Blackwell. 2184: 2146: 2121:Swinehart, IT; Badylak, SF (March 2016). 2097: 1871: 1861: 1818: 1596: 1557: 1418: 1340: 1283: 1273: 1220: 1201: 1108: 1000: 849: 666: 656: 184:in collaboration with researchers at the 155:Learn how and when to remove this message 1949:King's College London (March 10, 2020). 1532: 1313:Journal of Microscopy and Ultrastructure 981:Journal of Microscopy and Ultrastructure 543:, Canadian regenerative medicine company 348: 131:by replacing them with more appropriate 29: 2254: 2000: 691:"Regenerative Medicine. NIH Fact sheet" 400:to try to repair damaged heart tissue. 376: 114:too closely associated with the subject 14: 3976: 3812:Differential technological development 2678:Journal of the Royal Society Interface 2169: 2019: 1186: 1171:https://www.nsf.gov/pubs/2004/nsf0450/ 1053: 34:A colony of human embryonic stem cells 3555: 2726: 2046:Ratan-NM, M. Pharm (April 30, 2020). 1025:"Dr. Paul Niehans, Swiss Surgeon, 89" 936: 916:University of Nebraska Medical Center 906: 904: 645:International Journal of Cell Biology 638: 3618:Aldehyde-stabilized cryopreservation 3506: 3267:Physical medicine and rehabilitation 2438:Expert Opinion on Biological Therapy 2003:"Researchers Grow New Teeth in Mice" 96: 57:. Examples include the injection of 3901:Future-oriented technology analysis 3516: 2170:Hannan, Daniel (October 25, 2020). 793:Stem Cells in Regenerative Medicine 24: 3403:Medical Scientist Training Program 2555: 2048:"Repairing Teeth using Stem Cells" 2001:Normile, Dennis (August 3, 2009). 1743:"Centres of Regenerative Medicine" 1629: 1056:Tramp: The Life of Charlie Chaplin 901: 756:"Regenerative medicine glossary". 466:have been explored as sources for 25: 4005: 1921:10.1016/j.archoralbio.2013.11.005 1202:Alexander, Brian (January 2000). 1173:Viola, J., Lal, B., and Grad, O. 1086:. 7 December 2014. Archived from 3984:Vertebrate developmental biology 3955: 3535: 3525: 3515: 3505: 3496: 3495: 2647:10.1111/j.1582-4934.2008.00228.x 2283:Haller M J; et al. (2008). 1597:Oltermann, Philip (2016-03-24). 912:"What is Regenerative Medicine?" 696:. September 2006. Archived from 287:age-related macular degeneration 190:Johns Hopkins School of Medicine 112:may rely excessively on sources 101: 3536: 2547:. Duke Health. October 8, 2019. 2537: 2429: 2325: 2227: 2207: 2163: 2114: 2065: 2039: 2013: 1994: 1968: 1942: 1896: 1837: 1812: 1783: 1759: 1735: 1711: 1687: 1663: 1623: 1590: 1526: 1505: 1490:. Mirm.pitt.edu. Archived from 1480: 1455: 1412: 1375: 1357: 1300: 1241: 1195: 1180: 1164: 1129: 1111:Topics in Health Care Financing 1102: 1072: 1047: 1017: 968: 930: 344: 339:Chinese University of Hong Kong 225:University of Wisconsin–Madison 219:and its academic collaborators 186:University of Wisconsin–Madison 42:irreparable tissues or organs. 3393:Doctor of Osteopathic Medicine 2827:Oral and maxillofacial surgery 2020:Childs, Dan (April 13, 2009). 1723:Wake Forest School of Medicine 1533:Fountain, Henry (2012-01-12). 1248:Mao AS, Mooney DJ (Nov 2015). 866: 825: 784: 749: 714: 683: 632: 618: 575: 13: 1: 3928:Technology in science fiction 2561:Non-technical further reading 2450:10.1517/14712598.2015.1051528 2390:BioMed Research International 764:(4 Suppl): S1–88. July 2009. 568: 496:Induced pluripotent stem cell 434: 3373:Bachelor of Medical Sciences 3140:Neurosurgical anesthesiology 2752: 2301:10.1016/j.exphem.2008.01.009 2090:10.1016/j.actbio.2016.11.068 943:Dansk Medicinhistorisk Arbog 7: 937:Rahlf, Sidsel Hald (2009). 801:10.1007/978-1-59745-060-7_5 473: 407:, has been developed by an 331:Chinese Academy of Sciences 307: 10: 4010: 3933:Technology readiness level 3869:Technological unemployment 2052:News Medical Life Sciences 1325:10.1016/j.jmau.2015.05.002 1235:10.1089/152489001753309652 1210:. Vol. 8, no. 1. 1138:Tissue Engineering. Part A 993:10.1016/j.jmau.2015.05.002 234:In March 2000, Haseltine, 92: 85:grown organs and tissues ( 3951: 3916:Technological singularity 3876:Technological convergence 3794: 3596: 3589: 3491: 3413: 3351: 3112: 3040: 2995: 2904: 2775: 2760: 2623:Technical further reading 1568:10.1038/nature.2014.15915 1150:10.1089/ten.tea.2007.0412 3989:Regenerative biomedicine 3611:Microgravity bioprinting 3327:Transplantation medicine 3218:Clinical neurophysiology 3135:Obstetric anesthesiology 3055:Interventional radiology 2815:Digestive system surgery 2338:Stem Cells International 1909:Archives of Oral Biology 1863:10.3389/fneur.2019.00824 1254:Proc Natl Acad Sci U S A 918:. University of Nebraska 531:Regenerative endodontics 283:directed differentiation 249:de Barcelona, Professor 229:Johns Hopkins University 67:directed differentiation 3881:Technological evolution 3854:Exploratory engineering 3782:Whole genome sequencing 3198:Intensive care medicine 3172:Mass gathering medicine 3017:Maternal–fetal medicine 2579:Mayo Clinic Proceedings 1795:www.sps.tsinghua.edu.cn 1275:10.1073/pnas.1508520112 838:Genes & Development 516:Osteoarthritis#Research 458:Along with cord blood, 415:. Omega 3 is a natural 323:Northwestern University 255:University of Barcelona 3891:Technology forecasting 3886:Technological paradigm 3859:Proactionary principle 3743:Robot-assisted surgery 2790:Cardiothoracic surgery 2690:10.1098/rsif.2008.0442 2505:10.1126/sciadv.aax3203 2200:Bloomberg Businessweek 2127:Developmental Dynamics 1850:Frontiers in Neurology 1515:. sens.org. 2009-01-03 1054:Milton, Joyce (1998). 735:10.2217/17460751.3.1.1 596:10.2217/17460751.3.1.1 526:Regeneration in humans 468:mesenchymal stem cells 386:reconstructive surgery 354: 35: 3817:Disruptive innovation 3726:Regenerative medicine 3721:Personalized medicine 3583:Emerging technologies 3441:Personalized medicine 3300:Reproductive medicine 3225:Occupational medicine 3179:Evolutionary medicine 2567:Regenerative Medicine 1421:Regenerative Medicine 758:Regenerative Medicine 723:Regenerative Medicine 584:Regenerative Medicine 352: 298:Karolinska University 253:and his team, of the 245:In June 2008, at the 227:and John Gearhart of 39:Regenerative medicine 33: 18:Regenerative Medicine 3864:Technological change 3807:Collingridge dilemma 3461:Traditional medicine 3421:Alternative medicine 3288:Addiction psychiatry 3102:Transfusion medicine 3097:Medical microbiology 3012:Gynecologic oncology 2864:Reproductive surgery 2351:10.1155/2016/9756973 2220:Anchorage Daily News 1699:crn.northwestern.edu 1187:Bailey, Ron (2005). 658:10.1155/2016/6940283 552:Stem cell treatments 536:Rejuvenation (aging) 453:embryonic stem cells 451:stem cells (such as 423:was approved by the 394:orthopedic surgeries 382:Extracellular matrix 377:Extracellular matrix 327:University of Oxford 73:); the induction of 48:transplant rejection 3921:Technology scouting 3896:Accelerating change 3665:Genetic engineering 3483:History of medicine 3466:Veterinary medicine 3273:Preventive medicine 3125:Adolescent medicine 2967:Infectious diseases 2615:Scientific American 2497:2019SciA....5R3203H 2404:10.1155/2015/975302 2177:The Daily Telegraph 1982:. February 20, 2007 1771:english.gibh.cas.cn 1266:2015PNAS..11214452M 1191:. Prometheus Books. 1084:Home.cancerresearch 1031:. September 4, 1971 851:10.1101/gad.1540507 335:Tsinghua University 319:Stanford University 315:Columbia University 3994:Tissue engineering 3938:Technology roadmap 3758:Synthetic genomics 3748:Relational biology 3736:Tissue engineering 3660:Generative biology 3431:Molecular oncology 3388:Doctor of Medicine 3378:Master of Medicine 3295:Radiation oncology 3167:Emergency medicine 3120:Addiction medicine 3087:Clinical chemistry 3082:Clinical pathology 2874:Transplant surgery 2832:Orthopedic surgery 2810:Colorectal surgery 2139:10.1002/dvdy.24379 2078:Acta Biomaterialia 1539:The New York Times 1090:on 2 February 2020 1029:The New York Times 887:10.1002/bdrc.20137 562:Tooth regeneration 355: 302:Swedish Television 211:From 1995 to 1998 87:tissue engineering 36: 3971: 3970: 3790: 3789: 3753:Synthetic biology 3731:Stem-cell therapy 3714:engineered uterus 3628:Artificial organs 3549: 3548: 3383:Master of Surgery 3347: 3346: 3332:Tropical medicine 3278:Prison healthcare 3193:Hospital medicine 3157:Disaster medicine 3147:Aviation medicine 2962:Hospital medicine 2869:Surgical oncology 2854:Pediatric surgery 2848: 2795:Endocrine surgery 1513:"Sens Foundation" 1433:10.2217/rme.11.40 1058:. HarperCollins. 810:978-1-58829-797-6 770:10.2217/rme.09.s1 639:Mahla RS (2016). 511:Neuroregeneration 417:anti-inflammatory 294:Paolo Macchiarini 271:Paolo Macchiarini 251:Paolo Macchiarini 217:Geron Corporation 182:Geron Corporation 165: 164: 157: 65:obtained through 16:(Redirected from 4001: 3959: 3958: 3906:Horizon scanning 3822:Ephemeralization 3650:Brain transplant 3594: 3593: 3576: 3569: 3562: 3553: 3552: 3539: 3538: 3529: 3519: 3518: 3509: 3508: 3499: 3498: 3203:Medical genetics 3188:General practice 3065:Nuclear medicine 2940:Gastroenterology 2896:Vascular surgery 2846: 2773: 2772: 2747: 2740: 2733: 2724: 2723: 2719: 2709: 2668: 2658: 2602: 2591:10.4065/78.8.993 2549: 2548: 2541: 2535: 2534: 2524: 2491:(10): eaax3203. 2485:Science Advances 2476: 2470: 2469: 2433: 2427: 2426: 2416: 2406: 2380: 2374: 2373: 2363: 2353: 2329: 2323: 2322: 2312: 2280: 2271: 2270: 2252: 2243: 2242: 2231: 2225: 2224: 2211: 2205: 2204: 2191: 2182: 2181: 2167: 2161: 2160: 2150: 2118: 2112: 2111: 2101: 2069: 2063: 2062: 2060: 2058: 2043: 2037: 2036: 2034: 2032: 2017: 2011: 2010: 1998: 1992: 1991: 1989: 1987: 1972: 1966: 1965: 1963: 1961: 1946: 1940: 1939: 1937: 1935: 1900: 1894: 1893: 1875: 1865: 1841: 1835: 1834: 1832: 1831: 1816: 1810: 1809: 1807: 1806: 1797:. Archived from 1787: 1781: 1780: 1778: 1777: 1763: 1757: 1756: 1754: 1753: 1739: 1733: 1732: 1730: 1729: 1715: 1709: 1708: 1706: 1705: 1691: 1685: 1684: 1682: 1681: 1667: 1661: 1660: 1654: 1646: 1644: 1643: 1627: 1621: 1620: 1618: 1617: 1594: 1588: 1587: 1555: 1549: 1548: 1546: 1545: 1530: 1524: 1523: 1521: 1520: 1509: 1503: 1502: 1500: 1499: 1484: 1478: 1477: 1475: 1474: 1459: 1453: 1452: 1416: 1410: 1409: 1407: 1406: 1397:. Archived from 1379: 1373: 1372: 1367:. Archived from 1361: 1355: 1354: 1344: 1304: 1298: 1297: 1287: 1277: 1245: 1239: 1238: 1218: 1212: 1211: 1199: 1193: 1192: 1184: 1178: 1168: 1162: 1161: 1133: 1127: 1126: 1106: 1100: 1099: 1097: 1095: 1076: 1070: 1069: 1051: 1045: 1044: 1038: 1036: 1021: 1015: 1014: 1004: 972: 966: 965: 963: 961: 934: 928: 927: 925: 923: 908: 899: 898: 870: 864: 863: 853: 844:(11): 1292–315. 829: 823: 822: 788: 782: 781: 753: 747: 746: 718: 712: 711: 709: 708: 702: 695: 687: 681: 680: 670: 660: 636: 630: 629: 622: 616: 615: 579: 481:Artificial organ 429:Omega3 Surgibind 341:, among others. 160: 153: 149: 146: 140: 105: 97: 63:progenitor cells 21: 4009: 4008: 4004: 4003: 4002: 4000: 3999: 3998: 3974: 3973: 3972: 3967: 3947: 3786: 3775:Oncolytic virus 3677:Head transplant 3585: 3580: 3550: 3545: 3487: 3476:Chief physician 3409: 3354: 3343: 3337:Travel medicine 3322:Sports medicine 3305:Sexual medicine 3245:Palliative care 3240:Pain management 3184:Family medicine 3162:Diving medicine 3108: 3036: 2998: 2991: 2907: 2900: 2859:Plastic surgery 2805:General surgery 2785:Cardiac surgery 2766: 2764: 2756: 2751: 2684:(32): 209–232. 2625: 2585:(8): 993–1003. 2563: 2558: 2556:Further reading 2553: 2552: 2543: 2542: 2538: 2477: 2473: 2444:(9): 1293–306. 2434: 2430: 2381: 2377: 2330: 2326: 2281: 2274: 2267: 2253: 2246: 2239:Iceland Monitor 2233: 2232: 2228: 2213: 2212: 2208: 2203:. 27 June 2017. 2193: 2192: 2185: 2168: 2164: 2119: 2115: 2070: 2066: 2056: 2054: 2044: 2040: 2030: 2028: 2018: 2014: 1999: 1995: 1985: 1983: 1974: 1973: 1969: 1959: 1957: 1947: 1943: 1933: 1931: 1901: 1897: 1842: 1838: 1829: 1827: 1819:administrator. 1817: 1813: 1804: 1802: 1789: 1788: 1784: 1775: 1773: 1765: 1764: 1760: 1751: 1749: 1741: 1740: 1736: 1727: 1725: 1717: 1716: 1712: 1703: 1701: 1693: 1692: 1688: 1679: 1677: 1669: 1668: 1664: 1648: 1647: 1641: 1639: 1628: 1624: 1615: 1613: 1595: 1591: 1556: 1552: 1543: 1541: 1531: 1527: 1518: 1516: 1511: 1510: 1506: 1497: 1495: 1486: 1485: 1481: 1472: 1470: 1461: 1460: 1456: 1417: 1413: 1404: 1402: 1381: 1380: 1376: 1363: 1362: 1358: 1305: 1301: 1260:(47): 14452–9. 1246: 1242: 1219: 1215: 1200: 1196: 1185: 1181: 1169: 1165: 1134: 1130: 1107: 1103: 1093: 1091: 1078: 1077: 1073: 1066: 1052: 1048: 1034: 1032: 1023: 1022: 1018: 973: 969: 959: 957: 935: 931: 921: 919: 910: 909: 902: 871: 867: 830: 826: 811: 789: 785: 755: 754: 750: 719: 715: 706: 704: 700: 693: 689: 688: 684: 637: 633: 624: 623: 619: 580: 576: 571: 566: 476: 460:Wharton's jelly 439:Though uses of 437: 388:, treatment of 379: 347: 310: 296:was fired from 266:SENS Foundation 247:Hospital ClĂ­nic 213:Michael D. West 161: 150: 144: 141: 126: 106: 95: 79:transplantation 28: 23: 22: 15: 12: 11: 5: 4007: 3997: 3996: 3991: 3986: 3969: 3968: 3966: 3965: 3952: 3949: 3948: 3946: 3945: 3940: 3935: 3930: 3925: 3924: 3923: 3918: 3913: 3908: 3903: 3898: 3888: 3883: 3878: 3873: 3872: 3871: 3861: 3856: 3851: 3850: 3849: 3844: 3839: 3834: 3824: 3819: 3814: 3809: 3804: 3798: 3796: 3792: 3791: 3788: 3787: 3785: 3784: 3779: 3778: 3777: 3767: 3762: 3761: 3760: 3750: 3745: 3740: 3739: 3738: 3733: 3723: 3718: 3717: 3716: 3706: 3701: 3696: 3695: 3694: 3687:Life extension 3684: 3682:Isolated brain 3679: 3674: 3673: 3672: 3662: 3657: 3652: 3647: 3645:Biofabrication 3642: 3641: 3640: 3635: 3633:Organ printing 3625: 3620: 3615: 3614: 3613: 3606:3D bioprinting 3602: 3600: 3591: 3587: 3586: 3579: 3578: 3571: 3564: 3556: 3547: 3546: 3544: 3543: 3533: 3523: 3513: 3503: 3492: 3489: 3488: 3486: 3485: 3480: 3479: 3478: 3468: 3463: 3458: 3453: 3448: 3443: 3438: 3433: 3428: 3423: 3417: 3415: 3414:Related topics 3411: 3410: 3408: 3407: 3406: 3405: 3395: 3390: 3385: 3380: 3375: 3370: 3365: 3363:Medical school 3359: 3357: 3349: 3348: 3345: 3344: 3342: 3341: 3340: 3339: 3329: 3324: 3319: 3317:Sleep medicine 3314: 3313: 3312: 3302: 3297: 3292: 3291: 3290: 3280: 3275: 3270: 3264: 3259: 3258: 3257: 3247: 3242: 3237: 3232: 3227: 3222: 3221: 3220: 3210: 3205: 3200: 3195: 3190: 3181: 3176: 3175: 3174: 3164: 3159: 3154: 3149: 3144: 3143: 3142: 3137: 3130:Anesthesiology 3127: 3122: 3116: 3114: 3110: 3109: 3107: 3106: 3105: 3104: 3099: 3094: 3089: 3084: 3079: 3069: 3068: 3067: 3062: 3060:Neuroradiology 3057: 3046: 3044: 3038: 3037: 3035: 3034: 3029: 3024: 3019: 3014: 3009: 3003: 3001: 2997:Obstetrics and 2993: 2992: 2990: 2989: 2984: 2979: 2974: 2969: 2964: 2959: 2954: 2949: 2948: 2947: 2937: 2932: 2927: 2922: 2912: 2910: 2902: 2901: 2899: 2898: 2893: 2892: 2891: 2881: 2879:Trauma surgery 2876: 2871: 2866: 2861: 2856: 2851: 2850: 2849: 2842:Otolaryngology 2839: 2834: 2829: 2824: 2819: 2818: 2817: 2812: 2802: 2797: 2792: 2787: 2781: 2779: 2770: 2768:subspecialties 2758: 2757: 2750: 2749: 2742: 2735: 2727: 2721: 2720: 2669: 2624: 2621: 2620: 2619: 2603: 2570: 2562: 2559: 2557: 2554: 2551: 2550: 2536: 2471: 2428: 2375: 2324: 2272: 2265: 2244: 2226: 2206: 2183: 2162: 2113: 2064: 2038: 2012: 1993: 1967: 1941: 1895: 1836: 1811: 1782: 1758: 1747:www.bhf.org.uk 1734: 1710: 1686: 1662: 1632:"Experimenten" 1622: 1589: 1550: 1525: 1504: 1479: 1454: 1427:(4): 431–435. 1411: 1374: 1371:on 2013-08-03. 1356: 1319:(3): 101–107. 1299: 1240: 1213: 1194: 1179: 1163: 1144:(7): 1449–50. 1128: 1101: 1071: 1064: 1046: 1016: 987:(3): 101–107. 967: 929: 900: 865: 824: 809: 783: 748: 713: 682: 631: 617: 573: 572: 570: 567: 565: 564: 559: 554: 549: 544: 538: 533: 528: 523: 518: 513: 508: 503: 501:Life extension 498: 493: 488: 483: 477: 475: 472: 436: 433: 390:chronic wounds 378: 375: 346: 343: 309: 306: 163: 162: 109: 107: 100: 94: 91: 71:cell therapies 26: 9: 6: 4: 3: 2: 4006: 3995: 3992: 3990: 3987: 3985: 3982: 3981: 3979: 3964: 3963: 3954: 3953: 3950: 3944: 3943:Transhumanism 3941: 3939: 3936: 3934: 3931: 3929: 3926: 3922: 3919: 3917: 3914: 3912: 3909: 3907: 3904: 3902: 3899: 3897: 3894: 3893: 3892: 3889: 3887: 3884: 3882: 3879: 3877: 3874: 3870: 3867: 3866: 3865: 3862: 3860: 3857: 3855: 3852: 3848: 3845: 3843: 3840: 3838: 3835: 3833: 3830: 3829: 3828: 3825: 3823: 3820: 3818: 3815: 3813: 3810: 3808: 3805: 3803: 3800: 3799: 3797: 3793: 3783: 3780: 3776: 3773: 3772: 3771: 3768: 3766: 3763: 3759: 3756: 3755: 3754: 3751: 3749: 3746: 3744: 3741: 3737: 3734: 3732: 3729: 3728: 3727: 3724: 3722: 3719: 3715: 3712: 3711: 3710: 3709:Organ culture 3707: 3705: 3702: 3700: 3697: 3693: 3690: 3689: 3688: 3685: 3683: 3680: 3678: 3675: 3671: 3668: 3667: 3666: 3663: 3661: 3658: 3656: 3655:De-extinction 3653: 3651: 3648: 3646: 3643: 3639: 3636: 3634: 3631: 3630: 3629: 3626: 3624: 3621: 3619: 3616: 3612: 3609: 3608: 3607: 3604: 3603: 3601: 3599: 3595: 3592: 3588: 3584: 3577: 3572: 3570: 3565: 3563: 3558: 3557: 3554: 3542: 3534: 3532: 3528: 3524: 3522: 3514: 3512: 3504: 3502: 3494: 3493: 3490: 3484: 3481: 3477: 3474: 3473: 3472: 3469: 3467: 3464: 3462: 3459: 3457: 3454: 3452: 3449: 3447: 3446:Public health 3444: 3442: 3439: 3437: 3434: 3432: 3429: 3427: 3426:Allied health 3424: 3422: 3419: 3418: 3416: 3412: 3404: 3401: 3400: 3399: 3396: 3394: 3391: 3389: 3386: 3384: 3381: 3379: 3376: 3374: 3371: 3369: 3366: 3364: 3361: 3360: 3358: 3356: 3350: 3338: 3335: 3334: 3333: 3330: 3328: 3325: 3323: 3320: 3318: 3315: 3311: 3308: 3307: 3306: 3303: 3301: 3298: 3296: 3293: 3289: 3286: 3285: 3284: 3281: 3279: 3276: 3274: 3271: 3268: 3265: 3263: 3260: 3256: 3253: 3252: 3251: 3248: 3246: 3243: 3241: 3238: 3236: 3235:Oral medicine 3233: 3231: 3230:Ophthalmology 3228: 3226: 3223: 3219: 3216: 3215: 3214: 3211: 3209: 3206: 3204: 3201: 3199: 3196: 3194: 3191: 3189: 3185: 3182: 3180: 3177: 3173: 3170: 3169: 3168: 3165: 3163: 3160: 3158: 3155: 3153: 3150: 3148: 3145: 3141: 3138: 3136: 3133: 3132: 3131: 3128: 3126: 3123: 3121: 3118: 3117: 3115: 3111: 3103: 3100: 3098: 3095: 3093: 3092:Cytopathology 3090: 3088: 3085: 3083: 3080: 3078: 3075: 3074: 3073: 3070: 3066: 3063: 3061: 3058: 3056: 3053: 3052: 3051: 3048: 3047: 3045: 3043: 3039: 3033: 3032:Urogynecology 3030: 3028: 3025: 3023: 3020: 3018: 3015: 3013: 3010: 3008: 3005: 3004: 3002: 3000: 2994: 2988: 2985: 2983: 2980: 2978: 2975: 2973: 2970: 2968: 2965: 2963: 2960: 2958: 2955: 2953: 2950: 2946: 2943: 2942: 2941: 2938: 2936: 2935:Endocrinology 2933: 2931: 2928: 2926: 2923: 2921: 2917: 2914: 2913: 2911: 2909: 2903: 2897: 2894: 2890: 2887: 2886: 2885: 2882: 2880: 2877: 2875: 2872: 2870: 2867: 2865: 2862: 2860: 2857: 2855: 2852: 2845: 2844: 2843: 2840: 2838: 2835: 2833: 2830: 2828: 2825: 2823: 2820: 2816: 2813: 2811: 2808: 2807: 2806: 2803: 2801: 2798: 2796: 2793: 2791: 2788: 2786: 2783: 2782: 2780: 2778: 2774: 2771: 2769: 2763: 2759: 2755: 2748: 2743: 2741: 2736: 2734: 2729: 2728: 2725: 2717: 2713: 2708: 2703: 2699: 2695: 2691: 2687: 2683: 2679: 2675: 2670: 2666: 2662: 2657: 2652: 2648: 2644: 2641:(3): 709–29. 2640: 2636: 2632: 2627: 2626: 2617: 2616: 2611: 2607: 2606:Kevin Strange 2604: 2600: 2596: 2592: 2588: 2584: 2580: 2576: 2571: 2568: 2565: 2564: 2546: 2540: 2532: 2528: 2523: 2518: 2514: 2510: 2506: 2502: 2498: 2494: 2490: 2486: 2482: 2475: 2467: 2463: 2459: 2455: 2451: 2447: 2443: 2439: 2432: 2424: 2420: 2415: 2410: 2405: 2400: 2396: 2392: 2391: 2386: 2379: 2371: 2367: 2362: 2357: 2352: 2347: 2343: 2339: 2335: 2328: 2320: 2316: 2311: 2306: 2302: 2298: 2295:(6): 710–15. 2294: 2290: 2286: 2279: 2277: 2268: 2266:9781444303537 2262: 2258: 2251: 2249: 2240: 2236: 2230: 2222: 2221: 2216: 2210: 2202: 2201: 2196: 2190: 2188: 2179: 2178: 2173: 2166: 2158: 2154: 2149: 2144: 2140: 2136: 2133:(3): 351–60. 2132: 2128: 2124: 2117: 2109: 2105: 2100: 2095: 2091: 2087: 2083: 2079: 2075: 2068: 2053: 2049: 2042: 2027: 2023: 2016: 2008: 2004: 1997: 1981: 1977: 1971: 1956: 1955:SciTech Daily 1952: 1945: 1930: 1926: 1922: 1918: 1915:(2): 158–66. 1914: 1910: 1906: 1899: 1891: 1887: 1883: 1879: 1874: 1869: 1864: 1859: 1855: 1851: 1847: 1840: 1826: 1822: 1815: 1801:on 2016-10-04 1800: 1796: 1792: 1786: 1772: 1768: 1762: 1748: 1744: 1738: 1724: 1720: 1714: 1700: 1696: 1690: 1676: 1672: 1666: 1658: 1652: 1637: 1633: 1626: 1612: 1608: 1604: 1600: 1593: 1585: 1581: 1577: 1573: 1569: 1565: 1561: 1554: 1540: 1536: 1529: 1514: 1508: 1494:on 2010-06-12 1493: 1489: 1483: 1468: 1464: 1458: 1450: 1446: 1442: 1438: 1434: 1430: 1426: 1422: 1415: 1401:on 2009-03-01 1400: 1396: 1392: 1388: 1384: 1378: 1370: 1366: 1360: 1352: 1348: 1343: 1338: 1334: 1330: 1326: 1322: 1318: 1314: 1310: 1303: 1295: 1291: 1286: 1281: 1276: 1271: 1267: 1263: 1259: 1255: 1251: 1244: 1236: 1232: 1228: 1224: 1217: 1209: 1205: 1198: 1190: 1183: 1176: 1172: 1167: 1159: 1155: 1151: 1147: 1143: 1139: 1132: 1124: 1120: 1116: 1112: 1105: 1089: 1085: 1081: 1075: 1067: 1061: 1057: 1050: 1043: 1030: 1026: 1020: 1012: 1008: 1003: 998: 994: 990: 986: 982: 978: 971: 956: 952: 948: 944: 940: 933: 917: 913: 907: 905: 896: 892: 888: 884: 881:(4): 265–80. 880: 876: 869: 861: 857: 852: 847: 843: 839: 835: 828: 820: 816: 812: 806: 802: 798: 794: 787: 779: 775: 771: 767: 763: 759: 752: 744: 740: 736: 732: 728: 724: 717: 703:on 2011-10-26 699: 692: 686: 678: 674: 669: 664: 659: 654: 650: 646: 642: 635: 628:. 8 May 2014. 627: 621: 613: 609: 605: 601: 597: 593: 589: 585: 578: 574: 563: 560: 558: 555: 553: 550: 548: 545: 542: 539: 537: 534: 532: 529: 527: 524: 522: 519: 517: 514: 512: 509: 507: 504: 502: 499: 497: 494: 492: 489: 487: 484: 482: 479: 478: 471: 469: 465: 461: 456: 454: 450: 446: 445:hematopoietic 442: 432: 430: 426: 422: 418: 414: 410: 406: 401: 399: 398:heart surgery 395: 391: 387: 383: 374: 370: 366: 364: 359: 351: 342: 340: 336: 332: 328: 324: 320: 316: 305: 303: 299: 295: 290: 288: 284: 280: 274: 272: 267: 264:In 2009, the 262: 260: 256: 252: 248: 243: 241: 237: 232: 230: 226: 222: 221:James Thomson 218: 214: 209: 205: 201: 199: 195: 194:differentiate 191: 187: 183: 177: 173: 169: 159: 156: 148: 138: 134: 130: 124: 120: 116: 115: 110:This section 108: 104: 99: 98: 90: 88: 84: 80: 76: 72: 68: 64: 60: 56: 51: 49: 43: 40: 32: 19: 3960: 3847:Robot ethics 3725: 3699:Nanomedicine 3670:Gene therapy 3451:Rural health 3436:Nanomedicine 2987:Rheumatology 2918: / 2837:Hand surgery 2822:Neurosurgery 2681: 2677: 2638: 2634: 2613: 2610:Viravuth Yin 2582: 2578: 2539: 2488: 2484: 2474: 2441: 2437: 2431: 2394: 2388: 2378: 2341: 2337: 2327: 2292: 2289:Exp. 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Index

Regenerative Medicine

transplant rejection
stem cells
stem cells
progenitor cells
directed differentiation
cell therapies
regeneration
transplantation
tissue engineering

too closely associated with the subject
verifiable
neutral
improve it
citations
reliable, independent, third-party sources
Learn how and when to remove this message
Geron Corporation
University of Wisconsin–Madison
Johns Hopkins School of Medicine
differentiate
pluripotency
Michael D. West
Geron Corporation
James Thomson
University of Wisconsin–Madison
Johns Hopkins University
Antony Atala

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