3496:
1199:
29:
1268:
is a type of ribonuclease that cleaves rRNA (16s rRNA and 23s rRNA) from transcribed polycistronic RNA operon in prokaryotes. It also digests double-stranded RNA (dsRNA)-Dicer family of RNAse, cutting pre-miRNA (60â70bp long) at a specific site and transforming it in miRNA (22â30bp), that is actively
1407:
is a ribonuclease of plant origin, which modulates SOS responses in bacteria, for a response to the stress of DNA damage by activation of the SOS mechanism by the RecA/LexA dependent signal transduction pathway that transcriptionally depresses a multiplicity of genes leading
1116:
Some cells also secrete copious quantities of non-specific RNases such as A and T1. RNases are, therefore, extremely common, resulting in very short lifespans for any RNA that is not in a protected environment. It is worth noting that all intracellular RNAs are protected from RNase activity by a
1108:
All organisms studied contain many RNases of two different classes, showing that RNA degradation is a very ancient and important process. As well as clearing of cellular RNA that is no longer required, RNases play key roles in the maturation of all RNA molecules, both messenger RNAs that carry
1583:
The active site looks like a rift valley where all the active site residues create the wall and bottom of the valley. The rift is very thin and the small substrate fits perfectly in the middle of the active site, which allows for perfect interaction with the residues. It actually has a little
1109:
genetic material for making proteins and non-coding RNAs that function in varied cellular processes. In addition, active RNA degradation systems are the first defense against RNA viruses and provide the underlying machinery for more advanced cellular immune strategies such as
1316:). In bacteria RNase P is also responsible for the catalytic activity of holoenzymes, which consist of an apoenzyme that forms an active enzyme system by combination with a coenzyme and determines the specificity of this system for a substrate. A form of RNase P that is a
1252:
is a ribonuclease that cleaves the RNA in a DNA/RNA duplex to produce ssDNA. RNase H is a non-specific endonuclease and catalyzes the cleavage of RNA via a hydrolytic mechanism, aided by an enzyme-bound divalent metal ion. RNase H leaves a 5'-phosphorylated
1423:
It is involved in processing the 16'-end of the 5s rRNA. It is related to chromosome separation and cell division. It is considered one of the components of cytoplasmic axial filament bundles. It is also thought that it can regulate the formation of this
1237:. It is specific for single-stranded RNAs. It cleaves the 3'-end of unpaired C and U residues, ultimately forming a 3'-phosphorylated product via a 2',3'-cyclic monophosphate intermediate. It does not require any cofactors for its activity
1605:. In addition to the cellular RNases that are released, there are several RNases that are present in the environment. RNases have evolved to have many extracellular functions in various organisms. For example, RNase 7, a member of the
1600:
in molecular biology experiments is greatly complicated by the presence of ubiquitous and hardy ribonucleases that degrade RNA samples. Certain RNases can be extremely hardy and inactivating them is difficult compared to neutralizing
1930:
Wachi M, Umitsuki G, Shimizu M, Takada A, Nagai K. Escherichia coli cafA gene encodes a novel RNase, designated as RNase G, involved in processing of the 5' end of 16S rRNA. Biochem
Biophys Res Commun. 1999;259(2):483â488.
1147:
for the RI-RNase A complex is ~20 fM under physiological conditions. RI is used in most laboratories that study RNA to protect their samples against degradation from environmental RNases.
1921:
Shamsher S. Kanwar*, Puranjan Mishra, Khem Raj Meena, Shruti Gupta and Rakesh Kumar, Ribonucleases and their
Applications, 2016, Journal of Advanced Biotechnology and Bioengineering
1629:
Noguchi S (July 2010). "Isomerization mechanism of aspartate to sexxxxxxxx implied by structures of
Ustilago sphaerogena ribonuclease U2 complexed with adenosine 3'-monophosphate".
1609:
superfamily, is secreted by human skin and serves as a potent antipathogen defence. In these secreted RNases, the enzymatic RNase activity may not even be necessary for its new,
1233:) is one of the hardiest enzymes in common laboratory usage; one method of isolating it is to boil a crude cellular extract until all enzymes other than RNase A are
2977:
1139:, which comprises a relatively large fraction of cellular protein (~0.1%) in some cell types, and which binds to certain ribonucleases with the highest affinity of any
2923:
2315:
Ahmed TAE, Udenigwe CC, Gomaa A. Editorial: Biotechnology and
Bioengineering Applications for Egg-Derived Biomaterials. Front Bioeng Biotechnol. 2021 Sep 20;9:756058
136:
1720:"Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution"
2585:
1100:, and comprise several sub-classes within the EC 2.7 (for the phosphorolytic enzymes) and 3.1 (for the hydrolytic enzymes) classes of enzymes.
2746:
2403:
1584:
curvature to the site which the substrate also has. Although usually most exo- and endoribonucleases are not sequence specific, recently
2842:
2231:"The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity"
1495:
is a close homolog of RNase II, but it can, unlike RNase II, degrade RNA with secondary structures without help of accessory factors.
2553:
2570:
2817:
1702:
1675:
1445:
84:
1984:"A type II secreted RNase of Legionella pneumophila facilitates optimal intracellular infection of Hartmannella vermiformis"
156:
2731:
2832:
2826:
2627:
2377:
1818:
2675:
1941:
Tamulaitis G, Kazlauskiene M, Manakova E, Venclovas Ä, Nwokeoji AO, Dickman MJ, Horvath P, Siksnys V (November 2014).
3215:
2786:
2575:
1883:"RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme"
1362:
is sequence specific for single-stranded RNAs. It cleaves 3'-end of all 4 residues, but preferentially 3'-end of As.
2893:
2781:
2702:
2612:
2565:
1588:/Cas system natively recognizing and cutting DNA was engineered to cleave ssRNA in a sequence-specific manner.
144:
3371:
3124:
3065:
3169:
2736:
2726:
3129:
3021:
2646:
2331:
Gerdes K, Christensen SK and Lobner-Olesen A (2005). "Prokaryotic toxin-antitoxin stress response loci".
1234:
1140:
3486:
2715:
2711:
2707:
2623:
2456:
140:
3472:
3459:
3446:
3433:
3420:
3407:
3394:
3356:
2883:
2439:
97:
3366:
3320:
3263:
2631:
2480:
2394:
1562:
1547:
1532:
1520:
1501:
1498:
1486:
1463:
1460:
1437:
1434:
1411:
1395:
1380:
1365:
1350:
1335:
1323:
1284:
1272:
1256:
1240:
1207:
1162:
that recognize and cleave specific sequences of single-stranded RNA have been recently classified.
3268:
2500:
2370:
3516:
3056:
2695:
1480:
1454:
1178:
1134:
1943:"Programmable RNA shredding by the type III-A CRISPR-Cas system of Streptococcus thermophilus"
1692:
1665:
1332:
is sequence specific for single-stranded RNAs. It cleaves 3'-end of unpaired A and U residues.
1308:. One of its functions is to cleave off a leader sequence from the 5' end of one stranded pre-
3289:
3208:
2991:
2888:
2680:
2641:
2505:
2427:
2229:
Huang YC, Lin YM, Chang TW, Wu SJ, Lee YS, Chang MD, Chen C, Wu SH, Liao YD (February 2007).
1144:
2350:
3361:
3174:
3009:
3004:
2937:
2597:
2422:
2183:
1170:
123:
1613:
function. For example, immune RNases act by destabilizing the cell membranes of bacteria.
8:
3325:
3029:
2999:
2803:
2798:
2722:
2658:
2444:
1312:. RNase P is one of two known multiple turnover ribozymes in nature (the other being the
1281:
is an interferon-induced nuclease that, upon activation, destroys all RNA within the cell
2187:
1377:
is sequence specific for single-stranded RNAs. It cleaves 3'-end of unpaired A residues.
1347:
is sequence specific for single-stranded RNAs. It cleaves 3'-end of unpaired G residues.
3531:
3526:
3258:
3162:
3014:
2495:
2485:
2363:
2296:
2271:
2206:
2171:
2111:
2059:
2034:
2010:
1983:
1858:
1833:
1795:
1771:"Bovine pancreatic ribonuclease: fifty years of the first enzymatic reaction mechanism"
1770:
1746:
1719:
1570:
1182:
1151:
2963:
2908:
2876:
2751:
2470:
2301:
2252:
2211:
2152:
2103:
2064:
2015:
1964:
1904:
1863:
1800:
1751:
1698:
1671:
1646:
1555:
1540:
1225:
1126:
163:
131:
89:
2131:"RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin"
2115:
65:
3304:
3299:
3273:
3201:
3039:
2619:
2524:
2519:
2475:
2291:
2283:
2242:
2201:
2191:
2142:
2095:
2054:
2046:
2005:
1995:
1954:
1894:
1881:
Holzmann J, Frank P, Löffler E, Bennett KL, Gerner C, Rossmanith W (October 2008).
1853:
1845:
1790:
1782:
1741:
1731:
1638:
1408:
to transit arrest of cell division as well as initiation of DNA repair.
1159:
1093:
119:
3521:
3351:
3335:
3248:
3141:
2955:
2871:
2866:
2861:
2774:
2769:
2529:
2407:
2345:
2196:
1959:
1942:
1736:
1174:
1122:
1097:
77:
2355:
3500:
3389:
3330:
3114:
3109:
3104:
2490:
2465:
2461:
2434:
2417:
2050:
1899:
1882:
1597:
1215:
2170:
Köten B, Simanski M, GlÀser R, Podschun R, Schröder JM, Harder J (July 2009).
2099:
1642:
3510:
3294:
3253:
2855:
2764:
2514:
1125:, formation of an RNA·RNA duplex, and folding within an RNA protein complex (
38:
3243:
2982:
2636:
2557:
2305:
2256:
2247:
2230:
2215:
2172:"RNase 7 contributes to the cutaneous defense against Enterococcus faecium"
2156:
2147:
2130:
2107:
2068:
2019:
2000:
1968:
1908:
1867:
1849:
1804:
1755:
1650:
1514:
1166:
2084:"The RNase a superfamily: generation of diversity and innate host defense"
93:
3467:
3402:
3238:
3157:
2928:
2822:
2685:
2651:
2589:
1529:
is the major contributor for the 3'-to-5' maturation of many stable RNAs.
1476:
1450:
1398:
2287:
1565:
1550:
1535:
1504:
1466:
1414:
1383:
1368:
1353:
1338:
1287:
1259:
1243:
1210:
3134:
1940:
1610:
1440:
1328:
1786:
1559:
degrades single-stranded RNA from 5'-to-3', exists only in eukaryotes.
1229:
3441:
3415:
3047:
2846:
2759:
2386:
1264:
1118:
1085:
2083:
1165:
RNases play a critical role in many biological processes, including
1059:
1053:
1046:
1040:
1034:
1028:
1022:
1016:
1010:
1004:
998:
992:
986:
980:
974:
968:
962:
956:
950:
944:
938:
932:
926:
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914:
908:
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896:
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860:
854:
848:
842:
836:
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824:
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806:
800:
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788:
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764:
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746:
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734:
728:
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608:
602:
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584:
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572:
566:
560:
554:
548:
542:
536:
530:
524:
518:
512:
506:
500:
494:
488:
482:
476:
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458:
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428:
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410:
404:
398:
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386:
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368:
362:
356:
350:
344:
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332:
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320:
314:
308:
302:
296:
290:
284:
278:
272:
266:
260:
254:
248:
242:
236:
230:
224:
218:
212:
206:
200:
194:
188:
181:
175:
169:
3495:
3092:
3087:
3082:
2903:
2538:
2390:
1471:
1373:
1358:
1343:
1313:
1297:
1081:
72:
3099:
3077:
3072:
2690:
1606:
1525:
1509:
1491:
1419:
1403:
1388:
1317:
1292:
1277:
1248:
3454:
3224:
3119:
3052:
2945:
2543:
2451:
1585:
1305:
1269:
involved in the regulation of transcription and mRNA life-time.
151:
1834:"Retroviral integrase superfamily: the structural perspective"
3428:
3061:
2812:
2808:
2035:"T2 Family ribonucleases: ancient enzymes with diverse roles"
1602:
1591:
1154:, which cleave highly specific sequences of double-stranded
1092:
into smaller components. Ribonucleases can be divided into
2793:
2670:
2663:
2607:
2602:
2272:"RNase A ribonucleases and host defense: an evolving story"
2169:
1880:
1309:
1177:(angiosperms). Many stress-response toxins of prokaryotic
1110:
113:
60:
3193:
1934:
1198:
1301:
1296:
is a type of ribonuclease that is unique in that it is a
1155:
1089:
1219:
is an RNase that is commonly used in research. RNase A (
28:
1697:. Springer Science & Business Media. p. 237.
1670:. Springer Science & Business Media. p. 556.
1320:
and does not contain RNA has recently been discovered.
3484:
16:
Class of enzyme that catalyzes the degradation of RNA
1981:
1769:
Cuchillo CM, Nogués MV, Raines RT (September 2011).
1768:
1544:
degrades short oligonucleotides to mononucleotides.
1193:
1711:
1428:
2681:Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
2385:
1717:
3508:
1718:Ramage HR, Connolly LE, Cox JS (December 2009).
1392:is specific for polyadenine and polyuridine RNA.
2228:
1657:
2128:
1982:Rossier O, Dao J, Cianciotto NP (March 2009).
1513:is involved in the 3'-to-5' processing of pre-
1304:that acts as a catalyst in the same way as an
3209:
2371:
2081:
2032:
1667:Peptide Growth Factors and Their Receptors II
1663:
1684:
1181:have been shown to have RNase activity and
3216:
3202:
2378:
2364:
1825:
1622:
27:
2295:
2269:
2246:
2205:
2195:
2146:
2058:
2009:
1999:
1958:
1898:
1857:
1794:
1745:
1735:
1694:Developmental Biology of Flowering Plants
1592:RNase contamination during RNA extraction
2324:D'Alessio G and Riordan JF, eds. (1997)
1690:
1664:Sporn MB, Roberts AB (6 December 2012).
1574:is a close homolog of Exoribonuclease I.
1197:
2571:Ubiquitin carboxy-terminal hydrolase L1
2326:Ribonucleases: Structures and Functions
2129:Harder J, Schroder JM (November 2002).
2082:Dyer KD, Rosenberg HF (November 2006).
1831:
1628:
3509:
3197:
3151:either deoxy- or ribo-
2359:
2351:Integrated Enzyme Database for EC 3.1
1446:Polynucleotide Phosphorylase (PNPase)
2732:Protein serine/threonine phosphatase
1578:
1223:, bovine pancreatic ribonuclease A:
2833:Cyclic nucleotide phosphodiesterase
2827:Clostridium perfringens alpha toxin
2628:Tartrate-resistant acid phosphatase
2235:The Journal of Biological Chemistry
2135:The Journal of Biological Chemistry
1132:Another mechanism of protection is
36:Ribonuclease U2 with AMP PDB entry
13:
2676:Pyruvate dehydrogenase phosphatase
14:
3543:
2576:4-hydroxybenzoyl-CoA thioesterase
2339:
1188:
3494:
2346:IUBMB Enzyme Database for EC 3.1
2033:Luhtala N, Parker R (May 2010).
1194:Major types of endoribonucleases
2894:N-acetylglucosamine-6-sulfatase
2782:Sphingomyelin phosphodiesterase
2263:
2222:
2163:
2122:
2075:
2026:
1975:
1924:
1429:Major types of exoribonucleases
1117:number of strategies including
2703:Inositol-phosphate phosphatase
2566:Palmitoyl protein thioesterase
2039:Trends in Biochemical Sciences
1915:
1874:
1811:
1762:
1691:Raghavan V (6 December 2012).
1:
3066:RNA-induced silencing complex
1616:
108:Available protein structures:
3170:Serratia marcescens nuclease
2737:Dual-specificity phosphatase
2727:Protein tyrosine phosphatase
2276:Journal of Leukocyte Biology
2197:10.1371/journal.pone.0006424
1960:10.1016/j.molcel.2014.09.027
1737:10.1371/journal.pgen.1000767
7:
3223:
2647:Fructose 1,6-bisphosphatase
1832:Nowotny M (February 2009).
1141:protein-protein interaction
1103:
10:
3548:
2318:
2051:10.1016/j.tibs.2010.02.002
1931:doi:10.1006/bbrc.1999.0806
1900:10.1016/j.cell.2008.09.013
1819:"Library Preparation Kits"
3380:
3372:MichaelisâMenten kinetics
3344:
3313:
3282:
3231:
3150:
3038:
2990:
2976:
2954:
2936:
2922:
2902:
2884:Galactosamine-6 sulfatase
2841:
2745:
2584:
2552:
2440:6-phosphogluconolactonase
2402:
2270:Rosenberg HF (May 2008).
2100:10.1007/s11030-006-9028-2
1643:10.1107/S0907444910019621
162:
150:
130:
112:
107:
103:
83:
71:
59:
51:
46:
26:
21:
3264:Diffusion-limited enzyme
2632:Purple acid phosphatases
1631:Acta Crystallographica D
1179:toxin-antitoxin systems
3057:Microprocessor complex
2696:Beta-propeller phytase
2248:10.1074/jbc.M607321200
2148:10.1074/jbc.M207587200
2001:10.1099/mic.0.023218-0
1850:10.1038/embor.2008.256
1481:nucleotidyltransferase
1455:nucleotidyltransferase
1203:
1135:ribonuclease inhibitor
1076:(commonly abbreviated
3357:EadieâHofstee diagram
3290:Allosteric regulation
2992:Endodeoxyribonuclease
2889:Iduronate-2-sulfatase
2642:Glucose 6-phosphatase
2428:Butyrylcholinesterase
1201:
1145:dissociation constant
3367:LineweaverâBurk plot
3175:Micrococcal nuclease
3010:Deoxyribonuclease IV
3005:Deoxyribonuclease II
2938:Exodeoxyribonuclease
2598:Alkaline phosphatase
2423:Acetylcholinesterase
2333:Nat. Rev. Microbiol.
1202:Structure of RNase A
1171:self-incompatibility
34:Ustilago sphaerogena
3030:UvrABC endonuclease
3000:Deoxyribonuclease I
2723:Protein phosphatase
2659:Protein phosphatase
2457:Bile salt-dependent
2445:PAF acetylhydrolase
2288:10.1189/jlb.1107725
2188:2009PLoSO...4.6424K
2088:Molecular Diversity
1152:restriction enzymes
1088:the degradation of
3326:Enzyme superfamily
3259:Enzyme promiscuity
3163:Mung bean nuclease
3022:Restriction enzyme
3015:Restriction enzyme
1571:Exoribonuclease II
1204:
1129:particle or RNP).
3482:
3481:
3191:
3190:
3187:
3186:
3183:
3182:
2972:
2971:
2964:Oligonucleotidase
2909:deoxyribonuclease
2877:Steroid sulfatase
2752:Phosphodiesterase
2481:Hormone-sensitive
2328:, Academic Press.
1787:10.1021/bi201075b
1704:978-1-4612-1234-8
1677:978-3-642-74781-6
1598:extraction of RNA
1579:RNase specificity
1556:Exoribonuclease I
1541:Oligoribonuclease
1160:endoribonucleases
1127:ribonucleoprotein
1094:endoribonucleases
1071:
1070:
1067:
1066:
157:structure summary
3539:
3499:
3498:
3490:
3362:HanesâWoolf plot
3305:Enzyme activator
3300:Enzyme inhibitor
3274:Enzyme catalysis
3218:
3211:
3204:
3195:
3194:
3040:Endoribonuclease
3026:
3020:
2988:
2987:
2934:
2933:
2920:
2919:
2620:Acid phosphatase
2501:Monoacylglycerol
2411:ester hydrolases
2380:
2373:
2366:
2357:
2356:
2310:
2309:
2299:
2267:
2261:
2260:
2250:
2226:
2220:
2219:
2209:
2199:
2167:
2161:
2160:
2150:
2141:(48): 46779â84.
2126:
2120:
2119:
2079:
2073:
2072:
2062:
2030:
2024:
2023:
2013:
2003:
1994:(Pt 3): 882â90.
1979:
1973:
1972:
1962:
1938:
1932:
1928:
1922:
1919:
1913:
1912:
1902:
1878:
1872:
1871:
1861:
1829:
1823:
1822:
1815:
1809:
1808:
1798:
1766:
1760:
1759:
1749:
1739:
1730:(12): e1000767.
1715:
1709:
1708:
1688:
1682:
1681:
1661:
1655:
1654:
1626:
1475:functions as an
1449:functions as an
1302:ribonucleic acid
1232:
1175:flowering plants
1098:exoribonucleases
1062:
1056:
1049:
1043:
1037:
1031:
1025:
1019:
1013:
1007:
1001:
995:
989:
983:
977:
971:
965:
959:
953:
947:
941:
935:
929:
923:
917:
911:
905:
899:
893:
887:
881:
875:
869:
863:
857:
851:
845:
839:
833:
827:
821:
815:
809:
803:
797:
791:
785:
779:
773:
767:
761:
755:
749:
743:
737:
731:
725:
719:
713:
707:
701:
695:
689:
683:
677:
671:
665:
659:
653:
647:
641:
635:
629:
623:
617:
611:
605:
599:
593:
587:
581:
575:
569:
563:
557:
551:
545:
539:
533:
527:
521:
515:
509:
503:
497:
491:
485:
479:
473:
467:
461:
455:
449:
443:
437:
431:
425:
419:
413:
407:
401:
395:
389:
383:
377:
371:
365:
359:
353:
347:
341:
335:
329:
323:
317:
311:
305:
299:
293:
287:
281:
275:
269:
263:
257:
251:
245:
239:
233:
227:
221:
215:
209:
203:
197:
191:
184:
178:
172:
105:
104:
41:
31:
19:
18:
3547:
3546:
3542:
3541:
3540:
3538:
3537:
3536:
3507:
3506:
3505:
3493:
3485:
3483:
3478:
3390:Oxidoreductases
3376:
3352:Enzyme kinetics
3340:
3336:List of enzymes
3309:
3278:
3249:Catalytic triad
3227:
3222:
3192:
3179:
3146:
3034:
3024:
3018:
2981:
2968:
2956:Exoribonuclease
2950:
2927:
2911:
2907:
2898:
2872:Arylsulfatase L
2867:Arylsulfatase B
2862:Arylsulfatase A
2837:
2750:
2741:
2580:
2548:
2410:
2398:
2384:
2342:
2321:
2313:
2268:
2264:
2227:
2223:
2168:
2164:
2127:
2123:
2080:
2076:
2031:
2027:
1980:
1976:
1939:
1935:
1929:
1925:
1920:
1916:
1879:
1875:
1830:
1826:
1817:
1816:
1812:
1781:(37): 7835â41.
1767:
1763:
1716:
1712:
1705:
1689:
1685:
1678:
1662:
1658:
1637:(Pt 7): 843â9.
1627:
1623:
1619:
1594:
1581:
1431:
1224:
1196:
1191:
1158:, a variety of
1123:polyadenylation
1106:
1080:) is a type of
1058:
1052:
1045:
1039:
1033:
1027:
1021:
1015:
1009:
1003:
997:
991:
985:
979:
973:
967:
961:
955:
949:
943:
937:
931:
925:
919:
913:
907:
901:
895:
889:
883:
877:
871:
865:
859:
853:
847:
841:
835:
829:
823:
817:
811:
805:
799:
793:
787:
781:
775:
769:
763:
757:
751:
745:
739:
733:
727:
721:
715:
709:
703:
697:
691:
685:
679:
673:
667:
661:
655:
649:
643:
637:
631:
625:
619:
613:
607:
601:
595:
589:
583:
577:
571:
565:
559:
553:
547:
541:
535:
529:
523:
517:
511:
505:
499:
493:
487:
481:
475:
469:
463:
457:
451:
445:
439:
433:
427:
421:
415:
409:
403:
397:
391:
385:
379:
373:
367:
361:
355:
349:
343:
337:
331:
325:
319:
313:
307:
301:
295:
289:
283:
277:
271:
265:
259:
253:
247:
241:
235:
229:
223:
217:
211:
205:
199:
193:
187:
180:
174:
168:
42:
37:
17:
12:
11:
5:
3545:
3535:
3534:
3529:
3524:
3519:
3504:
3503:
3480:
3479:
3477:
3476:
3463:
3450:
3437:
3424:
3411:
3398:
3384:
3382:
3378:
3377:
3375:
3374:
3369:
3364:
3359:
3354:
3348:
3346:
3342:
3341:
3339:
3338:
3333:
3328:
3323:
3317:
3315:
3314:Classification
3311:
3310:
3308:
3307:
3302:
3297:
3292:
3286:
3284:
3280:
3279:
3277:
3276:
3271:
3266:
3261:
3256:
3251:
3246:
3241:
3235:
3233:
3229:
3228:
3221:
3220:
3213:
3206:
3198:
3189:
3188:
3185:
3184:
3181:
3180:
3178:
3177:
3172:
3167:
3166:
3165:
3154:
3152:
3148:
3147:
3145:
3144:
3139:
3138:
3137:
3132:
3127:
3122:
3112:
3107:
3102:
3097:
3096:
3095:
3090:
3085:
3080:
3070:
3069:
3068:
3059:
3044:
3042:
3036:
3035:
3033:
3032:
3027:
3012:
3007:
3002:
2996:
2994:
2985:
2974:
2973:
2970:
2969:
2967:
2966:
2960:
2958:
2952:
2951:
2949:
2948:
2942:
2940:
2931:
2917:
2900:
2899:
2897:
2896:
2891:
2886:
2881:
2880:
2879:
2874:
2869:
2864:
2851:
2849:
2839:
2838:
2836:
2835:
2830:
2820:
2815:
2806:
2801:
2796:
2791:
2790:
2789:
2779:
2778:
2777:
2772:
2762:
2756:
2754:
2743:
2742:
2740:
2739:
2734:
2729:
2720:
2719:
2718:
2700:
2699:
2698:
2688:
2683:
2678:
2673:
2668:
2667:
2666:
2656:
2655:
2654:
2644:
2639:
2634:
2617:
2616:
2615:
2610:
2605:
2594:
2592:
2582:
2581:
2579:
2578:
2573:
2568:
2562:
2560:
2550:
2549:
2547:
2546:
2541:
2535:
2534:
2533:
2532:
2527:
2522:
2511:
2510:
2509:
2508:
2506:Diacylglycerol
2503:
2498:
2493:
2488:
2483:
2478:
2473:
2468:
2459:
2448:
2447:
2442:
2437:
2435:Pectinesterase
2432:
2431:
2430:
2425:
2418:Cholinesterase
2414:
2412:
2400:
2399:
2383:
2382:
2375:
2368:
2360:
2354:
2353:
2348:
2341:
2340:External links
2338:
2337:
2336:
2329:
2320:
2317:
2312:
2311:
2282:(5): 1079â87.
2262:
2241:(7): 4626â33.
2221:
2162:
2121:
2074:
2025:
1974:
1947:Molecular Cell
1933:
1923:
1914:
1873:
1824:
1810:
1761:
1710:
1703:
1683:
1676:
1656:
1620:
1618:
1615:
1593:
1590:
1580:
1577:
1576:
1575:
1560:
1545:
1530:
1518:
1496:
1484:
1458:
1430:
1427:
1426:
1425:
1409:
1393:
1378:
1363:
1348:
1333:
1321:
1282:
1270:
1254:
1238:
1195:
1192:
1190:
1189:Classification
1187:
1119:5' end capping
1105:
1102:
1069:
1068:
1065:
1064:
166:
160:
159:
154:
148:
147:
134:
128:
127:
117:
110:
109:
101:
100:
87:
81:
80:
75:
69:
68:
63:
57:
56:
53:
49:
48:
44:
43:
32:
24:
23:
15:
9:
6:
4:
3:
2:
3544:
3533:
3530:
3528:
3525:
3523:
3520:
3518:
3517:Ribonucleases
3515:
3514:
3512:
3502:
3497:
3492:
3491:
3488:
3474:
3470:
3469:
3464:
3461:
3457:
3456:
3451:
3448:
3444:
3443:
3438:
3435:
3431:
3430:
3425:
3422:
3418:
3417:
3412:
3409:
3405:
3404:
3399:
3396:
3392:
3391:
3386:
3385:
3383:
3379:
3373:
3370:
3368:
3365:
3363:
3360:
3358:
3355:
3353:
3350:
3349:
3347:
3343:
3337:
3334:
3332:
3331:Enzyme family
3329:
3327:
3324:
3322:
3319:
3318:
3316:
3312:
3306:
3303:
3301:
3298:
3296:
3295:Cooperativity
3293:
3291:
3288:
3287:
3285:
3281:
3275:
3272:
3270:
3267:
3265:
3262:
3260:
3257:
3255:
3254:Oxyanion hole
3252:
3250:
3247:
3245:
3242:
3240:
3237:
3236:
3234:
3230:
3226:
3219:
3214:
3212:
3207:
3205:
3200:
3199:
3196:
3176:
3173:
3171:
3168:
3164:
3161:
3160:
3159:
3156:
3155:
3153:
3149:
3143:
3140:
3136:
3133:
3131:
3128:
3126:
3123:
3121:
3118:
3117:
3116:
3113:
3111:
3108:
3106:
3103:
3101:
3098:
3094:
3091:
3089:
3086:
3084:
3081:
3079:
3076:
3075:
3074:
3071:
3067:
3063:
3060:
3058:
3054:
3051:
3050:
3049:
3046:
3045:
3043:
3041:
3037:
3031:
3028:
3023:
3016:
3013:
3011:
3008:
3006:
3003:
3001:
2998:
2997:
2995:
2993:
2989:
2986:
2984:
2979:
2975:
2965:
2962:
2961:
2959:
2957:
2953:
2947:
2944:
2943:
2941:
2939:
2935:
2932:
2930:
2925:
2921:
2918:
2915:
2910:
2905:
2901:
2895:
2892:
2890:
2887:
2885:
2882:
2878:
2875:
2873:
2870:
2868:
2865:
2863:
2860:
2859:
2858:
2857:
2856:arylsulfatase
2853:
2852:
2850:
2848:
2844:
2840:
2834:
2831:
2828:
2824:
2821:
2819:
2816:
2814:
2810:
2807:
2805:
2802:
2800:
2797:
2795:
2792:
2788:
2785:
2784:
2783:
2780:
2776:
2773:
2771:
2768:
2767:
2766:
2765:Phospholipase
2763:
2761:
2758:
2757:
2755:
2753:
2748:
2744:
2738:
2735:
2733:
2730:
2728:
2724:
2721:
2717:
2713:
2709:
2706:
2705:
2704:
2701:
2697:
2694:
2693:
2692:
2689:
2687:
2684:
2682:
2679:
2677:
2674:
2672:
2669:
2665:
2662:
2661:
2660:
2657:
2653:
2650:
2649:
2648:
2645:
2643:
2640:
2638:
2635:
2633:
2629:
2625:
2621:
2618:
2614:
2611:
2609:
2606:
2604:
2601:
2600:
2599:
2596:
2595:
2593:
2591:
2587:
2583:
2577:
2574:
2572:
2569:
2567:
2564:
2563:
2561:
2559:
2555:
2551:
2545:
2542:
2540:
2537:
2536:
2531:
2528:
2526:
2523:
2521:
2518:
2517:
2516:
2515:Phospholipase
2513:
2512:
2507:
2504:
2502:
2499:
2497:
2494:
2492:
2489:
2487:
2484:
2482:
2479:
2477:
2474:
2472:
2469:
2467:
2463:
2460:
2458:
2455:
2454:
2453:
2450:
2449:
2446:
2443:
2441:
2438:
2436:
2433:
2429:
2426:
2424:
2421:
2420:
2419:
2416:
2415:
2413:
2409:
2405:
2401:
2396:
2392:
2388:
2381:
2376:
2374:
2369:
2367:
2362:
2361:
2358:
2352:
2349:
2347:
2344:
2343:
2335:(3) 371â382.
2334:
2330:
2327:
2323:
2322:
2316:
2307:
2303:
2298:
2293:
2289:
2285:
2281:
2277:
2273:
2266:
2258:
2254:
2249:
2244:
2240:
2236:
2232:
2225:
2217:
2213:
2208:
2203:
2198:
2193:
2189:
2185:
2181:
2177:
2173:
2166:
2158:
2154:
2149:
2144:
2140:
2136:
2132:
2125:
2117:
2113:
2109:
2105:
2101:
2097:
2094:(4): 585â97.
2093:
2089:
2085:
2078:
2070:
2066:
2061:
2056:
2052:
2048:
2044:
2040:
2036:
2029:
2021:
2017:
2012:
2007:
2002:
1997:
1993:
1989:
1985:
1978:
1970:
1966:
1961:
1956:
1953:(4): 506â17.
1952:
1948:
1944:
1937:
1927:
1918:
1910:
1906:
1901:
1896:
1893:(3): 462â74.
1892:
1888:
1884:
1877:
1869:
1865:
1860:
1855:
1851:
1847:
1844:(2): 144â51.
1843:
1839:
1835:
1828:
1820:
1814:
1806:
1802:
1797:
1792:
1788:
1784:
1780:
1776:
1772:
1765:
1757:
1753:
1748:
1743:
1738:
1733:
1729:
1725:
1724:PLOS Genetics
1721:
1714:
1706:
1700:
1696:
1695:
1687:
1679:
1673:
1669:
1668:
1660:
1652:
1648:
1644:
1640:
1636:
1632:
1625:
1621:
1614:
1612:
1608:
1604:
1599:
1589:
1587:
1573:
1572:
1567:
1564:
1561:
1558:
1557:
1552:
1549:
1546:
1543:
1542:
1537:
1534:
1531:
1528:
1527:
1522:
1519:
1516:
1512:
1511:
1506:
1503:
1500:
1497:
1494:
1493:
1488:
1485:
1482:
1479:as well as a
1478:
1474:
1473:
1468:
1465:
1462:
1459:
1456:
1453:as well as a
1452:
1448:
1447:
1442:
1439:
1436:
1433:
1432:
1422:
1421:
1416:
1413:
1410:
1406:
1405:
1400:
1397:
1394:
1391:
1390:
1385:
1382:
1379:
1376:
1375:
1370:
1367:
1364:
1361:
1360:
1355:
1352:
1349:
1346:
1345:
1340:
1337:
1334:
1331:
1330:
1325:
1322:
1319:
1315:
1311:
1307:
1303:
1299:
1295:
1294:
1289:
1286:
1283:
1280:
1279:
1275:3.1.26.-??:
1274:
1271:
1267:
1266:
1261:
1258:
1255:
1251:
1250:
1245:
1242:
1239:
1236:
1231:
1227:
1222:
1218:
1217:
1212:
1209:
1206:
1205:
1200:
1186:
1184:
1180:
1176:
1172:
1168:
1163:
1161:
1157:
1153:
1148:
1146:
1142:
1138:
1136:
1130:
1128:
1124:
1120:
1114:
1112:
1101:
1099:
1095:
1091:
1087:
1083:
1079:
1075:
1061:
1055:
1051:
1048:
1042:
1036:
1030:
1024:
1018:
1012:
1006:
1000:
994:
988:
982:
976:
970:
964:
958:
952:
946:
940:
934:
928:
922:
916:
910:
904:
898:
892:
886:
880:
874:
868:
862:
856:
850:
844:
838:
832:
826:
820:
814:
808:
802:
796:
790:
784:
778:
772:
766:
760:
754:
748:
742:
736:
730:
724:
718:
712:
706:
700:
694:
688:
682:
676:
670:
664:
658:
652:
646:
640:
634:
628:
622:
616:
610:
604:
598:
592:
586:
580:
574:
568:
562:
556:
550:
544:
538:
532:
526:
520:
514:
508:
502:
496:
490:
484:
478:
472:
466:
460:
454:
448:
442:
436:
430:
424:
418:
412:
406:
400:
394:
388:
382:
376:
370:
364:
358:
352:
346:
340:
334:
328:
322:
316:
310:
304:
298:
292:
286:
280:
274:
268:
262:
256:
250:
244:
238:
232:
226:
220:
214:
208:
202:
196:
190:
183:
177:
171:
167:
165:
161:
158:
155:
153:
149:
146:
142:
138:
135:
133:
129:
125:
121:
118:
115:
111:
106:
102:
99:
95:
91:
88:
86:
82:
79:
76:
74:
70:
67:
64:
62:
58:
54:
50:
45:
40:
35:
30:
25:
20:
3468:Translocases
3465:
3452:
3439:
3426:
3413:
3403:Transferases
3400:
3387:
3244:Binding site
3025:}}
3019:{{
2983:Endonuclease
2914:ribonuclease
2913:
2854:
2637:Nucleotidase
2558:Thioesterase
2332:
2325:
2314:
2279:
2275:
2265:
2238:
2234:
2224:
2182:(7): e6424.
2179:
2175:
2165:
2138:
2134:
2124:
2091:
2087:
2077:
2045:(5): 253â9.
2042:
2038:
2028:
1991:
1988:Microbiology
1987:
1977:
1950:
1946:
1936:
1926:
1917:
1890:
1886:
1876:
1841:
1838:EMBO Reports
1837:
1827:
1813:
1778:
1775:Biochemistry
1774:
1764:
1727:
1723:
1713:
1693:
1686:
1666:
1659:
1634:
1630:
1624:
1595:
1582:
1569:
1554:
1539:
1524:
1508:
1490:
1470:
1444:
1418:
1402:
1387:
1372:
1357:
1342:
1327:
1291:
1276:
1263:
1247:
1220:
1214:
1167:angiogenesis
1164:
1149:
1133:
1131:
1115:
1107:
1077:
1074:Ribonuclease
1073:
1072:
1057:A:83-175
1050:A:82-174
1044:A:82-174
1038:B:82-174
1032:A:82-174
972:A:46-129
942:A:46-129
930:A:46-129
918:A:46-129
912:A:46-129
900:B:46-129
894:A:46-129
888:A:46-129
882:A:46-129
876:A:46-129
870:A:46-129
864:A:46-129
858:C:46-129
834:A:46-129
828:A:46-129
810:D:46-129
792:B:46-129
786:B:46-129
756:A:46-129
750:A:46-129
744:A:46-129
738:A:46-129
732:A:46-129
726:A:46-129
720:A:46-129
708:D:46-129
696:A:46-129
690:A:46-129
684:A:46-129
672:A:46-129
666:B:46-129
660:A:46-129
654:A:46-129
630:D:46-129
624:A:46-129
618:B:46-129
612:A:46-129
600:A:46-129
594:A:46-129
588:M:67-156
582:B:67-156
576:C:67-156
570:A:67-156
564:A:67-156
558:B:67-156
552:A:67-156
546:C:67-156
540:A:67-156
534:C:67-156
528:C:67-156
516:C:67-156
504:B:67-156
498:C:67-156
492:C:67-156
486:C:67-156
480:B:67-156
474:B:67-156
468:C:67-156
462:A:67-156
456:B:67-156
450:B:67-156
444:B:67-156
438:B:67-156
432:C:67-156
426:B:67-156
420:B:67-156
414:B:67-156
408:B:67-156
402:A:67-156
396:C:67-156
390:C:67-156
384:A:67-156
378:B:67-156
372:A:67-156
366:B:67-156
360:A:72-161
354:A:72-161
348:B:72-161
342:A:72-161
336:B:72-161
330:A:79-159
324:B:79-159
318:X:11-92
312:B:11-92
306:B:11-92
300:B:11-92
294:B:11-92
288:A:11-92
282:A:11-92
276:B:11-92
270:A:11-92
264:A:11-92
258:B:11-92
252:A:11-92
246:A:11-92
240:B:11-92
234:A:11-92
228:A:11-92
222:B:11-92
216:A:11-92
210:B:11-92
204:B:11-92
198:A:11-92
192:A:11-92
186:
185:B:11-92
179:A:56-137
173:A:56-137
55:Ribonuclease
33:
22:ribonuclease
3239:Active site
3158:Nuclease S1
2929:Exonuclease
2823:Lecithinase
2652:Calcineurin
2590:Phosphatase
2496:Lipoprotein
2486:Endothelial
1477:exonuclease
1451:exonuclease
1150:Similar to
1026::23-113
1020::45-127
1014::45-127
1008::45-127
1002::45-127
996::21-102
990::21-102
984::46-129
978::46-129
966::46-129
960::46-129
954::46-129
948::46-129
936::46-129
924::46-129
906::46-129
852::46-129
846::46-129
840::46-129
822::46-129
816::46-129
804::46-129
798::46-129
780::46-129
774::46-129
768::46-129
762::46-129
714::46-129
702::46-129
678::46-129
648::46-129
642::46-129
636::46-129
606::46-129
522::67-156
510::67-156
47:Identifiers
3511:Categories
3442:Isomerases
3416:Hydrolases
3283:Regulation
2471:Pancreatic
2408:Carboxylic
1617:References
1424:structure.
1329:RNase PhyM
120:structures
3532:EC 3.1.27
3527:EC 3.1.26
3321:EC number
3048:RNase III
2906:(includes
2847:Sulfatase
2760:Autotaxin
2624:Prostatic
2476:Lysosomal
2391:esterases
2387:Hydrolase
1521:EC number
1499:EC number
1487:EC number
1461:EC number
1435:EC number
1399:3.1.26.12
1326:3.1.??:
1324:EC number
1273:EC number
1265:RNase III
1235:denatured
1121:, 3' end
1086:catalyzes
78:IPR000026
3345:Kinetics
3269:Cofactor
3232:Activity
3142:RNase T1
2904:Nuclease
2539:Cutinase
2306:18211964
2257:17150966
2216:19641608
2176:PLOS ONE
2157:12244054
2116:20922592
2108:16969722
2069:20189811
2020:19246759
1969:25458845
1909:18984158
1868:19165139
1805:21838247
1756:20011113
1651:20606265
1566:3.1.13.1
1551:3.1.11.1
1536:3.1.13.3
1523:3.1.??:
1505:3.1.13.5
1489:3.1.??:
1472:RNase PH
1467:2.7.7.56
1420:RNase G
1415:3.1.26.-
1404:RNase E
1384:3.1.27.8
1374:RNase U2
1369:3.1.27.4
1359:RNase T2
1354:3.1.27.1
1344:RNase T1
1339:3.1.27.3
1314:ribosome
1298:ribozyme
1288:3.1.26.5
1260:3.1.26.3
1253:product.
1244:3.1.26.4
1211:3.1.27.5
1183:homology
1104:Function
1082:nuclease
1063:A:83-175
137:RCSB PDB
73:InterPro
3501:Biology
3455:Ligases
3225:Enzymes
3115:RNase E
3110:RNase Z
3105:RNase A
3100:RNase P
3073:RNase H
2691:Phytase
2491:Hepatic
2466:Lingual
2462:Gastric
2319:Sources
2297:2692241
2207:2712763
2184:Bibcode
2060:2888479
2011:2662391
1859:2637324
1796:3172371
1747:2781298
1611:exapted
1607:RNase A
1526:RNase T
1510:RNase D
1492:RNase R
1441:2.7.7.8
1389:RNase V
1318:protein
1293:RNase P
1278:RNase L
1249:RNase H
1216:RNase A
66:PF00545
3522:EC 3.1
3487:Portal
3429:Lyases
3053:Drosha
2978:3.1.21
2946:RecBCD
2924:3.1.11
2544:PETase
2452:Lipase
2304:
2294:
2255:
2214:
2204:
2155:
2114:
2106:
2067:
2057:
2018:
2008:
1967:
1907:
1866:
1856:
1803:
1793:
1754:
1744:
1701:
1674:
1649:
1603:DNases
1586:CRISPR
1306:enzyme
1143:; the
152:PDBsum
126:
116:
98:SUPFAM
52:Symbol
3381:Types
3062:Dicer
3017:;see
2843:3.1.6
2813:PDE4B
2809:PDE4A
2747:3.1.4
2716:IMPA3
2712:IMPA2
2708:IMPA1
2586:3.1.3
2554:3.1.2
2404:3.1.1
2112:S2CID
1515:tRNAs
1084:that
1078:RNase
94:SCOPe
85:SCOP2
3473:list
3466:EC7
3460:list
3453:EC6
3447:list
3440:EC5
3434:list
3427:EC4
3421:list
3414:EC3
3408:list
3401:EC2
3395:list
3388:EC1
2980:-31:
2926:-16:
2912:and
2818:PDE5
2804:PDE3
2799:PDE2
2794:PDE1
2686:PTEN
2671:OCRL
2664:PP2A
2613:ALPP
2608:ALPL
2603:ALPI
2397:3.1)
2302:PMID
2253:PMID
2212:PMID
2153:PMID
2104:PMID
2065:PMID
2016:PMID
1965:PMID
1905:PMID
1887:Cell
1864:PMID
1801:PMID
1752:PMID
1699:ISBN
1672:ISBN
1647:PMID
1596:The
1310:tRNA
1300:â a
1230:2AAS
1221:e.g.
1169:and
1137:(RI)
1111:RNAi
1096:and
1060:1r4y
1054:1de3
1047:1jbs
1041:1jbt
1035:1jbr
1029:1aqz
1023:1rtu
1017:1rck
1011:1fus
1005:1rcl
999:1fut
993:1rds
987:1rms
981:1rgk
975:4rnt
969:1i2f
963:5rnt
957:8rnt
951:2aae
945:7rnt
939:1iyy
933:3gsp
927:1hyf
921:2gsp
915:2bu4
909:1i3i
903:1lra
897:2aad
891:1tto
885:2bir
879:1loy
873:1g02
867:5bir
861:1i3f
855:1q9e
849:3bir
843:9rnt
837:5gsp
831:1lov
825:1fzu
819:1rn4
813:1rgl
807:3hoh
801:2rnt
795:4bir
789:1rgc
783:1ch0
777:6rnt
771:1bu4
765:1gsp
759:1ygw
753:7gsp
747:5hoh
741:1trp
735:1hz1
729:5bu4
723:1rhl
717:4bu4
711:1rga
705:4hoh
699:1rnt
693:1rn1
687:3bu4
681:1i2g
675:1det
669:1trq
663:1bir
657:1i0x
651:1low
645:4gsp
639:6gsp
633:3rnt
627:2hoh
621:1i2e
615:1bvi
609:1fys
603:1rls
597:1i0v
591:1b2m
585:1brn
579:1x1x
573:1b21
567:1rnb
561:1fw7
555:1x1u
549:1a2p
543:1bng
537:1bne
531:1brj
525:1brs
519:1yvs
513:1b2s
507:1bnr
501:1b20
495:1b27
489:1b2u
483:1bri
477:1x1y
471:1bse
465:1bsc
459:1b2z
453:1b2x
447:1bni
441:1x1w
435:1b3s
429:1bsb
423:1bsa
417:1bnj
411:1bgs
405:1bnf
399:1bns
393:1brk
387:1brg
381:1brh
375:1ban
369:1bsd
363:1bao
357:1buj
351:1gov
345:1gou
339:1goy
333:2rbi
327:1pyl
321:1py3
315:1ynv
309:1gmr
303:1i8v
297:1rgh
291:1rgg
285:1rgf
279:1gmp
273:1sar
267:1uci
261:1gmq
255:1rsn
249:1c54
243:1t2i
237:1rge
231:1ucl
225:1box
219:1t2h
213:1ay7
207:1lni
201:1ucj
195:2sar
189:1i70
182:1uck
176:1mgr
170:1mgw
145:PDBj
141:PDBe
124:ECOD
114:Pfam
90:1brn
61:Pfam
39:3agn
3135:4/5
2292:PMC
2284:doi
2243:doi
2239:282
2202:PMC
2192:doi
2143:doi
2139:277
2096:doi
2055:PMC
2047:doi
2006:PMC
1996:doi
1992:155
1955:doi
1895:doi
1891:135
1854:PMC
1846:doi
1791:PMC
1783:doi
1742:PMC
1732:doi
1639:doi
1443::
1226:PDB
1173:in
1156:DNA
1090:RNA
164:PDB
132:PDB
3513::
3093:2C
3088:2B
3083:2A
3064::
3055::
2845::
2725::
2714:,
2710:,
2626:)/
2588::
2556::
2525:A2
2520:A1
2406::
2395:EC
2389::
2300:.
2290:.
2280:83
2278:.
2274:.
2251:.
2237:.
2233:.
2210:.
2200:.
2190:.
2178:.
2174:.
2151:.
2137:.
2133:.
2110:.
2102:.
2092:10
2090:.
2086:.
2063:.
2053:.
2043:35
2041:.
2037:.
2014:.
2004:.
1990:.
1986:.
1963:.
1951:56
1949:.
1945:.
1903:.
1889:.
1885:.
1862:.
1852:.
1842:10
1840:.
1836:.
1799:.
1789:.
1779:50
1777:.
1773:.
1750:.
1740:.
1726:.
1722:.
1645:.
1635:66
1633:.
1568::
1563:EC
1553::
1548:EC
1538::
1533:EC
1507::
1502:EC
1469::
1464:EC
1438:EC
1417::
1412:EC
1401::
1396:EC
1386::
1381:EC
1371::
1366:EC
1356::
1351:EC
1341::
1336:EC
1290::
1285:EC
1262::
1257:EC
1246::
1241:EC
1228::
1213::
1208:EC
1185:.
1113:.
143:;
139:;
122:/
96:/
92:/
3489::
3475:)
3471:(
3462:)
3458:(
3449:)
3445:(
3436:)
3432:(
3423:)
3419:(
3410:)
3406:(
3397:)
3393:(
3217:e
3210:t
3203:v
3130:3
3125:2
3120:1
3078:1
2916:)
2829:)
2825:(
2811:/
2787:1
2775:D
2770:C
2749::
2630:/
2622:(
2530:B
2464:/
2393:(
2379:e
2372:t
2365:v
2308:.
2286::
2259:.
2245::
2218:.
2194::
2186::
2180:4
2159:.
2145::
2118:.
2098::
2071:.
2049::
2022:.
1998::
1971:.
1957::
1911:.
1897::
1870:.
1848::
1821:.
1807:.
1785::
1758:.
1734::
1728:5
1707:.
1680:.
1653:.
1641::
1517:.
1483:.
1457:.
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