207:: a saponin similar to the structure of sarsasapogenin found in beth root. In March 1944, the company made the first kilo of progesterone, which was sold at $ 50/gram. After a dispute in the company in 1945, Marker severed ties with Syntex SA. Because Marker was the only person in the company who knew how to do the synthesis of progesterone, they could no longer produce the drug. Marker however went to work with Botanica-mex, a company based in Texcoco. The company later was sold to Gedeon Richter Ltd. where they started using both cabeza de negro and barbasco (yam) to make progesterone.
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where the side chain was chemically reactive due to the two oxygen atoms connected to the same carbon. The newly found reactivity of the side chain can be used to remove most of the atoms in the side chain. After most of the atoms are removed from the side chain, a steroid ring is left. After a few
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The
University of Maryland Department of Chemistry and Biochemistry presents the Russell E. Marker Outstanding Freshman Award to a single freshman student each year for outstanding academic and laboratory
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Lecture series in astronomy, astrophysics, chemistry, evolutionary biology, genetics, math, and physical sciences are held annually at Penn State in
Russell Marker's honor.
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Mexican
Chemical Society at the VI International Symposium on the Chemistry of Natural Products in Mexico City (1969)
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Marker, Russell E.; Kamm, Oliver; Fleming, George H.; Popkin, Alexander H.; Wittle, Eugene L. (April 1, 1937).
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In 1937 he coauthored the article, "Sterols. X. Cholesterol
Derivatives," with Oliver Kamm, George H. Fleming,
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Lehmann P, Bolivar A, Quintero R (1973). "Russell E. Marker – Pioneer of the
Mexican steroid industry".
153:. This was the first practical synthesis of progesterone. It was also a precursor in the preparation of
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Emeric Somlo, Federico
Lehmann and Russell Marker came together to make a new company in Mexico named
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When Marker found that there was a similar structure to sarsasapogenin in Beth Roots, a member of the
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Today, progesterone can be used to make cortisone and oral contraceptives.
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257:"Marker Degradation: Creation of the Mexican Steroid Hormone Industry"
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chemical modifications, a steroid ring can lead to the creation of
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In 1926, he married
Mildred Collins (1899–1985) and worked as an
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Loriaux, D Lynn (2008). "Russell Earl Marker (1902–1995)".
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22:(March 12, 1902 – March 3, 1995) was an American
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The New York Times OBITUARIES, Thursday, March 9, 1995
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SA. This company used
Mexican plant, Cabeza de Negro (
144:In 1938, he proposed a new molecular structure for
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197:), to create progesterone. Species of the genus
34:. Later in his career, he went on to found a
449:Businesspeople in the pharmaceutical industry
61:. This eventually led to the development at
49:from chemical constituents found in Mexican
454:University of Maryland, College Park alumni
175:. He left the company in May 1945 to found
222:Chemical Congress of North America (1975)
124:where he came up with the concept of the
361:Journal of the American Chemical Society
138:Journal of the American Chemical Society
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356:"Sterols. X. Cholesterol Derivatives"
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105:in 1924 from the same institution.
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85:He was born on March 12, 1902, in
30:system when he was working at the
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459:People from Hagerstown, Maryland
73:– and to the development of the
67:combined oral contraceptive pill
164:, he began his work to develop
464:20th-century American chemists
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375:– via ACS Publications.
285:Journal of Chemical Education
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340:10.1097/TEN.0b013e31817d4077
120:. He then began work at the
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16:American chemist (1902–1995)
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42:when he successfully made
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264:American Chemical Society
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171:In March 1944 he formed
166:the Marker degradation
95:University of Maryland
75:Mexican barbasco trade
387:"Russell Earl Marker"
118:Indian Head, Maryland
114:Naval Powder Factory
87:Hagerstown, Maryland
373:10.1021/ja01283a007
328:The Endocrinologist
297:1973JChEd..50..195L
133:Alexander H. Popkin
20:Russell Earl Marker
194:Dioscorea mexicana
183:Marker degradation
110:analytical chemist
103:physical chemistry
89:. He received his
59:Marker degradation
305:10.1021/ed050p195
291:(3). ACS: 195–9.
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38:industry in
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162:lily family
423:Categories
269:2017-11-04
234:References
205:diosgenin
200:Dioscorea
155:cortisone
81:Biography
71:cortisone
57:known as
398:21 March
203:contain
313:4569922
293:Bibcode
112:at the
97:and an
65:of the
55:process
36:steroid
24:chemist
439:Syntex
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214:Honors
189:Syntex
173:Syntex
63:Syntex
40:Mexico
260:(PDF)
53:in a
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309:PMID
99:M.S.
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51:yams
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