988:
601:"Genetic organization of the chromosome region surrounding mecA in clinical staphylococcal strains: role of IS431-mediated mecI deletion in expression of resistance in mecA-carrying, low-level methicillin-resistant Staphylococcus haemolyticus"
650:"Detection of staphylococcal cassette chromosome mec type XI carrying highly divergent mecA, mecI, mecR1, blaZ, and ccr genes in human clinical isolates of clonal complex 130 methicillin-resistant Staphylococcus aureus"
793:
Liu J, Chen D, Peters BM, Li L, Li B, Xu Z, Shirliff ME (December 2016). "Staphylococcal chromosomal cassettes mec (SCCmec): A mobile genetic element in methicillin-resistant
Staphylococcus aureus".
240:
are connected by joining (J) regions, considered non-essential but capable of carrying extra antimicrobial resistance determinants. These are categorized as J1, J2, and J3, based on their SCC
928:"Methicillin-resistant coagulase-negative staphylococci on pig farms as a reservoir of heterogeneous staphylococcal cassette chromosome mec elements"
70:
is a 21 to 60 kb long genetic element that confers broad-spectrum β-lactam resistance to MRSA. Moreover, additional genetic elements like Tn
271:
256:
gene complexes. J3 (formerly the I-R region) is found downstream of the mec gene complex, extending to the left chromosomal junction.
422:"Acquisition of methicillin resistance and progression of multiantibiotic resistance in methicillin-resistant Staphylococcus aureus"
561:
Hiramatsu K, Cui L, Kuroda M, Ito T (October 2001). "The emergence and evolution of methicillin-resistant
Staphylococcus aureus".
1029:
373:"A new class of genetic element, staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus"
121:
complex is divided further into five types (I through V) based on the arrangement of regulatory genetic features such as
1053:
746:"Classification of staphylococcal cassette chromosome mec (SCCmec): guidelines for reporting novel SCCmec elements"
698:"Classification of staphylococcal cassette chromosome mec (SCCmec): guidelines for reporting novel SCCmec elements"
244:
positions. J1, also known as the L-C region, lies between the right chromosomal junction and upstream of the
1022:
1048:
830:"Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology"
63:
1058:
303:
290:
Staphylococcal strains isolated from pig farms were found to carry several different types of SCC
1015:
33:
879:"Origin and molecular evolution of the determinant of methicillin resistance in staphylococci"
648:
Shore AC, Deasy EC, Slickers P, Brennan G, O'Connell B, Monecke S, et al. (August 2011).
282:
149:), and insertion sequences (IS), is categorized into five classes (A to E). Class A includes
939:
8:
943:
960:
927:
903:
878:
854:
829:
770:
745:
722:
697:
674:
649:
538:
503:
353:
574:
965:
926:
Tulinski P, Fluit AC, Wagenaar JA, Mevius D, van de Vijver L, Duim B (January 2012).
908:
859:
810:
775:
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630:
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600:
578:
543:
484:
479:
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443:
402:
397:
372:
345:
340:
323:
98:
elements have been classified into fourteen types (I through XIV). One region is the
616:
388:
357:
955:
947:
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841:
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523:
474:
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38:
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which have the capability to render resistance to various non-β-lactam drugs.
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111:
55:
46:
876:
877:
Tsubakishita S, Kuwahara-Arai K, Sasaki T, Hiramatsu K (October 2010).
52:
278:
995:
294:, suggesting that they may serve as a reservoir of these elements.
42:
987:
126:
248:
gene. J2, previously the C-M region, is situated between the
925:
90:
elements are identical (in fact, SCC elements without the
647:
504:"Current Status of Staphylococcal Cassette Chromosome
560:
460:
321:
281:-negative staphylococcal species and was acquired by
598:
370:
1040:
181:. Class C, with two versions (C1, C2), contains
792:
461:Hanssen AM, Ericson Sollid JU (February 2006).
322:Hanssen AM, Ericson Sollid JU (February 2006).
1023:
827:
599:Katayama Y, Ito T, Hiramatsu K (July 2001).
463:"SCCmec in staphylococci: genes on the move"
419:
371:Katayama Y, Ito T, Hiramatsu K (June 2000).
324:"SCCmec in staphylococci: genes on the move"
45:species. This genetic sequence includes the
1030:
1016:
62:strains to spread the gene in the wild by
959:
902:
853:
769:
721:
673:
624:
537:
527:
478:
437:
396:
339:
467:FEMS Immunology and Medical Microbiology
454:
328:FEMS Immunology and Medical Microbiology
110:gene complex including genes coding for
74:, pT181, and pUB110 can be found in SCC
1041:
932:Applied and Environmental Microbiology
501:
883:Antimicrobial Agents and Chemotherapy
750:Antimicrobial Agents and Chemotherapy
702:Antimicrobial Agents and Chemotherapy
654:Antimicrobial Agents and Chemotherapy
605:Antimicrobial Agents and Chemotherapy
377:Antimicrobial Agents and Chemotherapy
94:gene do exist.) As of December 2021,
16:Staphylococcus mobile genetic element
982:
828:Lakhundi S, Zhang K (October 2018).
594:
592:
420:Ito T, Hiramatsu K (December 1998).
27:staphylococcal cassette chromosome
13:
51:gene coding for resistance to the
14:
1070:
589:
81:
986:
756:(12): 4961–4967. December 2009.
708:(12): 4961–4967. December 2009.
480:10.1111/j.1574-695X.2005.00009.x
341:10.1111/j.1574-695X.2005.00009.x
197:orientation. Class D includes IS
919:
870:
821:
786:
738:
617:10.1128/AAC.45.7.1955-1963.2001
389:10.1128/AAC.44.6.1549-1555.2000
261:
690:
641:
554:
495:
413:
364:
315:
58:and is the only known way for
1:
834:Clinical Microbiology Reviews
807:10.1016/j.micpath.2016.10.028
575:10.1016/s0966-842x(01)02175-8
309:
1002:. You can help Knowledge by
7:
529:10.3390/antibiotics11010086
297:
10:
1075:
981:
502:Uehara Y (January 2022).
439:10.3349/ymj.1998.39.6.526
106:gene. The other is the
64:horizontal gene transfer
1054:Mobile genetic elements
304:Mobile genetic elements
795:Microbial Pathogenesis
563:Trends in Microbiology
426:Yonsei Medical Journal
272:methicillin-resistant
209:; Class E consists of
141:gene, its regulators (
102:complex including the
34:mobile genetic element
277:likely originated in
274:Staphylococcus aureus
236:gene complexes in SCC
952:10.1128/AEM.05594-11
895:10.1128/AAC.00356-10
846:10.1128/CMR.00020-18
762:10.1128/AAC.00579-09
714:10.1128/aac.00579-09
666:10.1128/AAC.00187-11
944:2012ApEnM..78..299T
133:gene complex in SCC
1049:Molecular biology
1011:
1010:
889:(10): 4352–4359.
193:, differing in IS
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660:(8): 3765–3773.
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611:(7): 1955–1963.
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383:(6): 1549–1555.
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165:. Class B has IS
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569:(10): 486–493.
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1059:Genetics stubs
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938:(2): 299–304.
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432:(6): 526–533.
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82:Classification
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60:Staphylococcus
39:Staphylococcus
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1004:expanding it
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262:Distribution
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112:recombinases
107:
103:
99:
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91:
87:
85:
75:
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67:
59:
47:
37:
28:
26:
21:
19:
18:
516:Antibiotics
473:(1): 8–20.
334:(1): 8–20.
86:Not all SCC
56:methicillin
1043:Categories
310:References
205:, partial
185:, partial
173:, partial
53:antibiotic
801:: 56–67.
522:(1): 86.
284:S. aureus
279:coagulase
270:found in
43:bacterial
996:genetics
970:22081567
913:20679504
864:30209034
815:27836760
780:19721075
732:19721075
684:21636525
635:11408208
583:11597450
548:35052963
489:16420592
448:10097679
407:10817707
358:37999833
350:16420592
298:See also
177:, and IS
161:, and IS
961:3255757
940:Bibcode
904:2944575
855:6148192
771:2786320
723:2786320
675:3147645
539:8772726
266:The SCC
153:, full
127:inducer
32:, is a
968:
958:
911:
901:
862:
852:
813:
778:
768:
730:
720:
682:
672:
633:
623:
581:
546:
536:
487:
446:
405:
395:
356:
348:
129:. The
96:SCCmec
994:This
840:(4).
626:90585
398:89911
354:S2CID
219:mecR1
207:mecR1
187:mecR1
175:mecR1
155:mecR1
143:mecR1
125:, an
123:mecR1
66:. SCC
25:, or
1000:stub
966:PMID
909:PMID
860:PMID
811:PMID
776:PMID
728:PMID
680:PMID
631:PMID
579:PMID
544:PMID
508:(SCC
485:PMID
444:PMID
403:PMID
346:PMID
252:and
232:and
228:The
223:mecI
215:mecC
211:blaZ
203:mecA
189:, IS
183:mecA
171:mecA
167:1272
159:mecI
151:mecA
147:mecI
117:The
104:mecA
92:mecA
76:mec,
48:mecA
956:PMC
948:doi
899:PMC
891:doi
850:PMC
842:doi
803:doi
799:101
766:PMC
758:doi
718:PMC
710:doi
670:PMC
662:doi
621:PMC
613:doi
571:doi
534:PMC
524:doi
510:mec
506:mec
475:doi
434:doi
393:PMC
385:doi
336:doi
292:mec
268:mec
254:mec
250:ccr
246:ccr
242:mec
238:mec
234:mec
230:ccr
199:431
195:431
191:431
179:431
163:431
139:mec
135:mec
131:mec
119:mec
108:ccr
100:mec
88:mec
72:554
68:mec
36:of
29:mec
22:mec
20:SCC
1045::
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954:.
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930:.
907:.
897:.
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885:.
881:.
858:.
848:.
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832:.
809:.
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774:.
764:.
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716:.
706:53
704:.
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678:.
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656:.
652:.
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607:.
603:.
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805::
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760::
734:.
712::
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637:.
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