306:
283:
205:
180:
29:
312:
211:
2458:
1245:
1268:
1892:
Yamada K, Ohnishi T, Hashimoto K, Ohba H, Iwayama-Shigeno Y, Toyoshima M, Okuno A, Takao H, Toyota T, Minabe Y, Nakamura K, Shimizu E, Itokawa M, Mori N, Iyo M, Yoshikawa T (Jun 2005). "Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia
1194:
Since NMDA receptors
Dysfunction has been suggested as one of the promising hypotheses for the pathophysiology of schizophrenia, it has been shown that underexpression of this enzyme is an indicator, especially for the paranoid subtype. Treatment of schizophrenia with D-serine has been shown to play
1240:
pathway is thought to serve as a bleed valve that allows local stores of L-serine to be diverted away from D-serine as a means of muting the D-serine signaling pathway. The canonical tetraglycine loop that serves as a PLP phosphate binding pocket includes the active residues being F55, K56, G185,
55:
1710:
Fujii K, Maeda K, Hikida T, Mustafa AK, Balkissoon R, Xia J, Yamada T, Ozeki Y, Kawahara R, Okawa M, Huganir RL, Ujike H, Snyder SH, Sawa A (Feb 2006). "Serine racemase binds to PICK1: potential relevance to schizophrenia".
319:
218:
1367:
Morita, Yukitaka; Ujike, Hiroshi; Tanaka, Yuji; Otani, Kyohei; Kishimoto, Makiko; Morio, Akiko; Kotaka, Tatsuya; Okahisa, Yuko; Matsushita, Masayuki; Morikawa, Akiko; Hamase, Kenji (May 2007).
1826:
Hoffman HE, Jirásková J, Ingr M, Zvelebil M, Konvalinka J (Jan 2009). "Recombinant human serine racemase: enzymologic characterization and comparison with its mouse ortholog".
1930:
Xia M, Liu Y, Figueroa DJ, Chiu CS, Wei N, Lawlor AM, Lu P, Sur C, Koblan KS, Connolly TM (Jun 2004). "Characterization and localization of a human serine racemase".
866:
847:
141:
2103:
2076:
2019:
1469:
De
Miranda J, Santoro A, Engelender S, Wolosker H (Oct 2000). "Human serine racemase: moleular cloning, genomic organization and functional analysis".
2045:
1632:
Morita Y, Ujike H, Tanaka Y, Otani K, Kishimoto M, Morio A, Kotaka T, Okahisa Y, Matsushita M, Morikawa A, Hamase K, Zaitsu K, Kuroda S (May 2007).
1855:
Sarras H, Semeralul MO, Fadel MP, Feldcamp LA, Labrie V, Wong AH (Jul 2010). "Elevated PICK1 mRNA in schizophrenia increased SRR mRNA in suicide".
1349:
1331:
1673:
Steffek AE, Haroutunian V, Meador-Woodruff JH (Jul 2006). "Serine racemase protein expression in cortex and hippocampus in schizophrenia".
1414:
Fujii, K; Maeda, K; Hikida, T; Mustafa, A K; Balkissoon, R; Xia, J; Yamada, T; Ozeki, Y; Kawahara, R; Okawa, M; Huganir, R L (2006-02-01).
2135:
1570:"Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine"
52:
1113:
1106:
2512:
2061:
1260:
complex, associated with a conformational change upon nucleotide binding that depends upon interactions with Q89. The canonical
2012:
2531:
1314:
1293:
305:
2177:
2005:
1264:
of the divalent cation interaction site includes the active residues E210 and D216 within 2.1 angstroms of the ion.
282:
1318:
1297:
1209:. Serine racemase may have evolved from L-thre-hydroxyaspartate (L-THA) eliminase and served as the precursor to
911:
2333:
2120:
204:
179:
892:
2505:
121:
2144:
2448:
318:
217:
2434:
2421:
2408:
2395:
2382:
2369:
2356:
2318:
108:
311:
210:
2546:
2328:
2282:
2225:
2125:
2036:
1970:
1169:
1089:
1085:
1081:
1073:
1048:
1022:
1018:
1014:
1006:
981:
129:
1750:"Modulation of D-serine levels via ubiquitin-dependent proteasomal degradation of serine racemase"
2498:
2230:
2115:
1368:
1077:
1052:
1010:
985:
2032:
1997:
1257:
1748:
Dumin E, Bendikov I, Foltyn VN, Misumi Y, Ikehara Y, Kartvelishvily E, Wolosker H (Jul 2006).
1511:"Human Serine Racemase: Key Residues/Active Site Motifs and Their Relation to Enzyme Function"
2251:
2170:
1783:
StrĂsovskĂ˝ K, Jirásková J, Barinka C, Majer P, Rojas C, Slusher BS, Konvalinka J (Jan 2003).
193:
28:
2323:
2093:
1966:
1581:
1509:
Graham, Danielle L.; Beio, Matthew L.; Nelson, David L.; Berkowitz, David B. (2019-03-13).
8:
2486:
2287:
2057:
1261:
1237:
1236:
through the β-elimination of L-serine. This makes serine a known bifurcating enzyme. The
1217:
149:
1585:
1172:
2220:
2088:
2080:
1918:
1880:
1814:
1736:
1698:
1686:
1661:
1545:
1510:
1451:
1396:
1210:
153:
1943:
1801:
1784:
1604:
1569:
1482:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
700:
695:
690:
685:
680:
664:
659:
654:
649:
644:
639:
629:
624:
619:
614:
609:
604:
599:
594:
589:
2541:
2536:
1986:
1977:
1947:
1910:
1872:
1843:
1806:
1771:
1728:
1690:
1653:
1609:
1550:
1532:
1486:
1443:
1435:
1388:
101:
45:
1922:
1884:
1818:
1785:"Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate"
1740:
1702:
1455:
133:
2266:
2261:
2235:
2163:
1939:
1906:
1902:
1864:
1835:
1796:
1761:
1720:
1682:
1665:
1649:
1645:
1599:
1589:
1540:
1522:
1478:
1427:
1400:
1384:
1380:
398:
329:
273:
228:
2313:
2297:
2210:
1868:
373:
157:
1634:"A genetic variant of the serine racemase gene is associated with schizophrenia"
1369:"A Genetic Variant of the Serine Racemase Gene Is Associated with Schizophrenia"
1354:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1336:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2482:
2462:
2351:
2292:
1574:
Proceedings of the
National Academy of Sciences of the United States of America
474:
1839:
2525:
2256:
2215:
1536:
1527:
1439:
1188:
1187:
form, D-serine. D-serine acts as a neuronal signaling molecule by activating
576:
534:
412:
2205:
2107:
1951:
1914:
1876:
1847:
1810:
1775:
1766:
1749:
1732:
1694:
1657:
1613:
1594:
1554:
1490:
1447:
1392:
1229:
1221:
391:
170:
1724:
1431:
1415:
1153:
1148:
2429:
2364:
2200:
1633:
956:
937:
1228:
to D-serine and also the elimination of water from L-serine, generating
634:
2049:
1184:
290:
187:
137:
1416:"Serine racemase binds to PICK1: potential relevance to schizophrenia"
78:
74:
2478:
2403:
2377:
2028:
1253:
811:
357:
344:
256:
243:
145:
1252:
The enzyme is physiologically stimulated by divalent cations (e.g.,
2457:
1468:
1176:
1137:
1567:
1244:
1991:
1981:
1672:
1267:
1233:
1199:
1179:
enzyme in human biology to be identified. This enzyme converts L-
923:
878:
796:
792:
2027:
125:
2416:
2186:
1782:
1225:
1180:
1121:
833:
1568:
De
Miranda J, Panizzutti R, Foltyn VN, Wolosker H (Oct 2002).
2390:
1976:
Overview of all the structural information available in the
1854:
1825:
1206:
2155:
1891:
1747:
1508:
381:
1709:
1413:
1631:
1366:
2446:
546:
1256:) and is allosterically activated by the magnesium/
493:
dentate gyrus of hippocampal formation granule cell
1929:
1310:
1308:
1306:
1289:
1287:
1285:
328:
227:
2523:
1303:
1282:
16:Protein-coding gene in the species Homo sapiens
1315:GRCm38: Ensembl release 89: ENSMUSG00000001323
2506:
2171:
2013:
1561:
1462:
1294:GRCh38: Ensembl release 89: ENSG00000167720
2513:
2499:
2178:
2164:
2020:
2006:
722:serine family amino acid metabolic process
1969:at the U.S. National Library of Medicine
1800:
1765:
1603:
1593:
1544:
1526:
1220:dependent enzyme that catalyzes both the
1195:some role in ameliorating some symptoms.
2062:Phenylalanine racemase (ATP-hydrolysing)
1932:Brain Research. Molecular Brain Research
1266:
1243:
1271:Divalent cation (Mn) in serine racemase
2524:
2159:
2001:
732:cellular amino acid metabolic process
333:
294:
289:
232:
191:
186:
2472:
1504:
1502:
1500:
1828:Protein Expression and Purification
1754:The Journal of Biological Chemistry
717:response to organic cyclic compound
13:
1687:10.1097/01.wnr.0000230512.01339.72
1624:
1515:Frontiers in Molecular Biosciences
14:
2558:
1960:
1944:10.1016/j.molbrainres.2004.03.007
1497:
610:protein homodimerization activity
2456:
317:
310:
304:
281:
216:
209:
203:
178:
27:
1216:Mammalian serine racemase is a
1198:In humans, the serine racemase
660:D-serine ammonia-lyase activity
615:L-serine ammonia-lyase activity
1907:10.1016/j.biopsych.2005.03.018
1650:10.1016/j.biopsych.2006.07.025
1407:
1385:10.1016/j.biopsych.2006.07.025
1360:
1342:
1324:
757:response to lipopolysaccharide
535:More reference expression data
485:Region I of hippocampus proper
1:
2121:N-acetylneuraminate epimerase
1802:10.1016/s0014-5793(02)03855-3
1483:10.1016/S0378-1119(00)00356-5
1275:
782:L-serine biosynthetic process
762:D-serine biosynthetic process
747:pyruvate biosynthetic process
302:
201:
112:, ILV1, ISO1, serine racemase
2532:Genes on human chromosome 17
2485:. You can help Knowledge by
1869:10.1016/j.schres.2010.03.002
1241:G186, G187, G188, and S313.
7:
2185:
2145:Methylmalonyl CoA epimerase
772:protein homotetramerization
645:pyridoxal phosphate binding
590:threonine racemase activity
455:stromal cell of endometrium
10:
2563:
2471:
737:D-serine metabolic process
727:L-serine metabolic process
2342:
2334:Michaelis–Menten kinetics
2306:
2275:
2244:
2193:
2134:
2102:
2075:
2044:
1990:(Serine racemase) at the
1840:10.1016/j.pep.2008.09.003
1350:"Mouse PubMed Reference:"
1332:"Human PubMed Reference:"
1152:
1147:
1143:
1136:
1120:
1101:
1070:
1066:
1045:
1041:
1034:
1003:
999:
978:
974:
967:
954:
950:
935:
931:
922:
909:
905:
890:
886:
877:
864:
860:
845:
841:
832:
817:
810:
806:
790:
575:
571:
559:
554:
545:
532:
481:
472:
419:
410:
380:
372:
368:
351:
338:
301:
280:
271:
267:
250:
237:
200:
177:
168:
164:
119:
116:
106:
99:
94:
71:
66:
49:
44:
39:
35:
26:
21:
2226:Diffusion-limited enzyme
2126:Phosphopentose epimerase
1971:Medical Subject Headings
1528:10.3389/fmolb.2019.00008
665:serine racemase activity
2116:UDP-glucose 4-epimerase
2033:Epimerase and racemases
1114:Chr 11: 74.8 – 74.82 Mb
1893:and D-serine levels".
1857:Schizophrenia Research
1767:10.1074/jbc.M601971200
1595:10.1073/pnas.222421299
1272:
1249:
1248:PLP in serine racemase
1218:pyridoxal 5'-phosphate
505:superior frontal gyrus
2319:Eadie–Hofstee diagram
2252:Allosteric regulation
1895:Biological Psychiatry
1725:10.1038/sj.mp.4001776
1638:Biological Psychiatry
1432:10.1038/sj.mp.4001776
1373:Biological Psychiatry
1270:
1247:
1107:Chr 17: 2.3 – 2.33 Mb
655:magnesium ion binding
501:primary visual cortex
296:Chromosome 11 (mouse)
194:Chromosome 17 (human)
2329:Lineweaver–Burk plot
2094:Isocitrate epimerase
1713:Molecular Psychiatry
1420:Molecular Psychiatry
752:response to morphine
447:gastrocnemius muscle
67:List of PDB id codes
40:Available structures
2058:Amino-acid racemase
1586:2002PNAS...9914542D
1262:coordination sphere
691:apical part of cell
600:calcium ion binding
451:islet of Langerhans
423:ganglionic eminence
2288:Enzyme superfamily
2221:Enzyme promiscuity
2089:Mandelate racemase
1273:
1250:
1211:aspartate racemase
1202:is encoded by the
912:ENSMUSG00000001323
710:Biological process
696:neuronal cell body
674:Cellular component
635:catalytic activity
620:isomerase activity
605:PDZ domain binding
595:nucleotide binding
583:Molecular function
509:left lobe of liver
497:intercostal muscle
2494:
2493:
2444:
2443:
2153:
2152:
1760:(29): 20291–302.
1379:(10): 1200–1203.
1163:
1162:
1159:
1158:
1132:
1131:
1097:
1096:
1060:
1059:
1030:
1029:
993:
992:
963:
962:
944:
943:
918:
917:
899:
898:
873:
872:
854:
853:
802:
801:
777:brain development
630:metal ion binding
567:
566:
563:
562:
541:
540:
528:
527:
466:
465:
364:
363:
263:
262:
90:
89:
86:
85:
50:Ortholog search:
2554:
2515:
2508:
2501:
2473:
2461:
2460:
2452:
2324:Hanes–Woolf plot
2267:Enzyme activator
2262:Enzyme inhibitor
2236:Enzyme catalysis
2180:
2173:
2166:
2157:
2156:
2022:
2015:
2008:
1999:
1998:
1955:
1926:
1901:(12): 1493–503.
1888:
1851:
1822:
1804:
1779:
1769:
1744:
1706:
1669:
1618:
1617:
1607:
1597:
1565:
1559:
1558:
1548:
1530:
1506:
1495:
1494:
1466:
1460:
1459:
1411:
1405:
1404:
1364:
1358:
1357:
1346:
1340:
1339:
1328:
1322:
1312:
1301:
1291:
1145:
1144:
1116:
1109:
1092:
1064:
1063:
1055:
1039:
1038:
1035:RefSeq (protein)
1025:
997:
996:
988:
972:
971:
948:
947:
929:
928:
903:
902:
884:
883:
858:
857:
839:
838:
808:
807:
573:
572:
552:
551:
537:
477:
475:Top expressed in
470:
469:
427:ventricular zone
415:
413:Top expressed in
408:
407:
387:
386:
370:
369:
360:
347:
336:
321:
314:
308:
297:
285:
269:
268:
259:
246:
235:
220:
213:
207:
196:
182:
166:
165:
160:
111:
104:
81:
64:
63:
58:
37:
36:
31:
19:
18:
2562:
2561:
2557:
2556:
2555:
2553:
2552:
2551:
2547:Isomerase stubs
2522:
2521:
2520:
2519:
2469:
2467:
2455:
2447:
2445:
2440:
2352:Oxidoreductases
2338:
2314:Enzyme kinetics
2302:
2298:List of enzymes
2271:
2240:
2211:Catalytic triad
2189:
2184:
2154:
2149:
2130:
2098:
2071:
2067:Serine racemase
2040:
2026:
1967:Serine+racemase
1963:
1958:
1938:(1–2): 96–104.
1627:
1625:Further reading
1622:
1621:
1580:(22): 14542–7.
1566:
1562:
1507:
1498:
1467:
1463:
1412:
1408:
1365:
1361:
1348:
1347:
1343:
1330:
1329:
1325:
1313:
1304:
1292:
1283:
1278:
1175:) is the first
1166:Serine racemase
1154:View/Edit Mouse
1149:View/Edit Human
1112:
1105:
1102:Location (UCSC)
1088:
1084:
1080:
1076:
1072:
1051:
1047:
1021:
1017:
1013:
1009:
1005:
984:
980:
893:ENSG00000167720
786:
705:
686:plasma membrane
669:
625:glycine binding
533:
524:
519:
515:
513:proximal tubule
511:
507:
503:
499:
495:
491:
487:
473:
462:
457:
453:
449:
445:
443:muscle of thigh
441:
437:
433:
429:
425:
411:
355:
342:
334:
324:
323:
322:
315:
295:
272:Gene location (
254:
241:
233:
223:
222:
221:
214:
192:
169:Gene location (
158:SRR - orthologs
120:
107:
100:
73:
51:
17:
12:
11:
5:
2560:
2550:
2549:
2544:
2539:
2534:
2518:
2517:
2510:
2503:
2495:
2492:
2491:
2466:
2465:
2442:
2441:
2439:
2438:
2425:
2412:
2399:
2386:
2373:
2360:
2346:
2344:
2340:
2339:
2337:
2336:
2331:
2326:
2321:
2316:
2310:
2308:
2304:
2303:
2301:
2300:
2295:
2290:
2285:
2279:
2277:
2276:Classification
2273:
2272:
2270:
2269:
2264:
2259:
2254:
2248:
2246:
2242:
2241:
2239:
2238:
2233:
2228:
2223:
2218:
2213:
2208:
2203:
2197:
2195:
2191:
2190:
2183:
2182:
2175:
2168:
2160:
2151:
2150:
2148:
2147:
2141:
2139:
2132:
2131:
2129:
2128:
2123:
2118:
2112:
2110:
2100:
2099:
2097:
2096:
2091:
2085:
2083:
2073:
2072:
2070:
2069:
2064:
2054:
2052:
2042:
2041:
2025:
2024:
2017:
2010:
2002:
1996:
1995:
1974:
1962:
1961:External links
1959:
1957:
1956:
1927:
1889:
1863:(1–3): 236–7.
1852:
1823:
1780:
1745:
1707:
1681:(11): 1181–5.
1670:
1644:(10): 1200–3.
1628:
1626:
1623:
1620:
1619:
1560:
1496:
1477:(1–2): 183–8.
1461:
1426:(2): 150–157.
1406:
1359:
1341:
1323:
1302:
1280:
1279:
1277:
1274:
1191:in the brain.
1189:NMDA receptors
1161:
1160:
1157:
1156:
1151:
1141:
1140:
1134:
1133:
1130:
1129:
1127:
1125:
1118:
1117:
1110:
1103:
1099:
1098:
1095:
1094:
1068:
1067:
1061:
1058:
1057:
1043:
1042:
1036:
1032:
1031:
1028:
1027:
1001:
1000:
994:
991:
990:
976:
975:
969:
965:
964:
961:
960:
952:
951:
945:
942:
941:
933:
932:
926:
920:
919:
916:
915:
907:
906:
900:
897:
896:
888:
887:
881:
875:
874:
871:
870:
862:
861:
855:
852:
851:
843:
842:
836:
830:
829:
824:
819:
815:
814:
804:
803:
800:
799:
788:
787:
785:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
713:
711:
707:
706:
704:
703:
698:
693:
688:
683:
677:
675:
671:
670:
668:
667:
662:
657:
652:
647:
642:
640:lyase activity
637:
632:
627:
622:
617:
612:
607:
602:
597:
592:
586:
584:
580:
579:
569:
568:
565:
564:
561:
560:
557:
556:
549:
543:
542:
539:
538:
530:
529:
526:
525:
523:
522:
518:
514:
510:
506:
502:
498:
494:
490:
486:
482:
479:
478:
467:
464:
463:
461:
460:
456:
452:
448:
444:
440:
439:gastric mucosa
436:
432:
428:
424:
420:
417:
416:
404:
403:
395:
384:
378:
377:
374:RNA expression
366:
365:
362:
361:
353:
349:
348:
340:
337:
332:
326:
325:
316:
309:
303:
299:
298:
293:
287:
286:
278:
277:
265:
264:
261:
260:
252:
248:
247:
239:
236:
231:
225:
224:
215:
208:
202:
198:
197:
190:
184:
183:
175:
174:
162:
161:
118:
114:
113:
105:
97:
96:
92:
91:
88:
87:
84:
83:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
9:
6:
4:
3:
2:
2559:
2548:
2545:
2543:
2540:
2538:
2535:
2533:
2530:
2529:
2527:
2516:
2511:
2509:
2504:
2502:
2497:
2496:
2490:
2488:
2484:
2481:article is a
2480:
2475:
2474:
2470:
2464:
2459:
2454:
2453:
2450:
2436:
2432:
2431:
2426:
2423:
2419:
2418:
2413:
2410:
2406:
2405:
2400:
2397:
2393:
2392:
2387:
2384:
2380:
2379:
2374:
2371:
2367:
2366:
2361:
2358:
2354:
2353:
2348:
2347:
2345:
2341:
2335:
2332:
2330:
2327:
2325:
2322:
2320:
2317:
2315:
2312:
2311:
2309:
2305:
2299:
2296:
2294:
2293:Enzyme family
2291:
2289:
2286:
2284:
2281:
2280:
2278:
2274:
2268:
2265:
2263:
2260:
2258:
2257:Cooperativity
2255:
2253:
2250:
2249:
2247:
2243:
2237:
2234:
2232:
2229:
2227:
2224:
2222:
2219:
2217:
2216:Oxyanion hole
2214:
2212:
2209:
2207:
2204:
2202:
2199:
2198:
2196:
2192:
2188:
2181:
2176:
2174:
2169:
2167:
2162:
2161:
2158:
2146:
2143:
2142:
2140:
2137:
2133:
2127:
2124:
2122:
2119:
2117:
2114:
2113:
2111:
2109:
2108:Carbohydrates
2105:
2101:
2095:
2092:
2090:
2087:
2086:
2084:
2082:
2081:Hydroxy acids
2078:
2074:
2068:
2065:
2063:
2059:
2056:
2055:
2053:
2051:
2047:
2043:
2038:
2034:
2030:
2023:
2018:
2016:
2011:
2009:
2004:
2003:
2000:
1993:
1989:
1988:
1983:
1979:
1975:
1972:
1968:
1965:
1964:
1953:
1949:
1945:
1941:
1937:
1933:
1928:
1924:
1920:
1916:
1912:
1908:
1904:
1900:
1896:
1890:
1886:
1882:
1878:
1874:
1870:
1866:
1862:
1858:
1853:
1849:
1845:
1841:
1837:
1833:
1829:
1824:
1820:
1816:
1812:
1808:
1803:
1798:
1795:(1–3): 44–8.
1794:
1790:
1786:
1781:
1777:
1773:
1768:
1763:
1759:
1755:
1751:
1746:
1742:
1738:
1734:
1730:
1726:
1722:
1718:
1714:
1708:
1704:
1700:
1696:
1692:
1688:
1684:
1680:
1676:
1671:
1667:
1663:
1659:
1655:
1651:
1647:
1643:
1639:
1635:
1630:
1629:
1615:
1611:
1606:
1601:
1596:
1591:
1587:
1583:
1579:
1575:
1571:
1564:
1556:
1552:
1547:
1542:
1538:
1534:
1529:
1524:
1520:
1516:
1512:
1505:
1503:
1501:
1492:
1488:
1484:
1480:
1476:
1472:
1465:
1457:
1453:
1449:
1445:
1441:
1437:
1433:
1429:
1425:
1421:
1417:
1410:
1402:
1398:
1394:
1390:
1386:
1382:
1378:
1374:
1370:
1363:
1355:
1351:
1345:
1337:
1333:
1327:
1320:
1316:
1311:
1309:
1307:
1299:
1295:
1290:
1288:
1286:
1281:
1269:
1265:
1263:
1259:
1255:
1246:
1242:
1239:
1238:β-elimination
1235:
1231:
1227:
1223:
1219:
1214:
1212:
1208:
1205:
1201:
1196:
1192:
1190:
1186:
1182:
1178:
1174:
1171:
1167:
1155:
1150:
1146:
1142:
1139:
1135:
1128:
1126:
1123:
1119:
1115:
1111:
1108:
1104:
1100:
1093:
1091:
1087:
1083:
1079:
1075:
1069:
1065:
1062:
1056:
1054:
1050:
1044:
1040:
1037:
1033:
1026:
1024:
1020:
1016:
1012:
1008:
1002:
998:
995:
989:
987:
983:
977:
973:
970:
968:RefSeq (mRNA)
966:
959:
958:
953:
949:
946:
940:
939:
934:
930:
927:
925:
921:
914:
913:
908:
904:
901:
895:
894:
889:
885:
882:
880:
876:
869:
868:
863:
859:
856:
850:
849:
844:
840:
837:
835:
831:
828:
825:
823:
820:
816:
813:
809:
805:
798:
794:
789:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
743:
740:
738:
735:
733:
730:
728:
725:
723:
720:
718:
715:
714:
712:
709:
708:
702:
699:
697:
694:
692:
689:
687:
684:
682:
679:
678:
676:
673:
672:
666:
663:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
636:
633:
631:
628:
626:
623:
621:
618:
616:
613:
611:
608:
606:
603:
601:
598:
596:
593:
591:
588:
587:
585:
582:
581:
578:
577:Gene ontology
574:
570:
558:
553:
550:
548:
544:
536:
531:
520:
516:
512:
508:
504:
500:
496:
492:
488:
484:
483:
480:
476:
471:
468:
459:hair follicle
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
421:
418:
414:
409:
406:
405:
402:
400:
396:
394:
393:
389:
388:
385:
383:
379:
375:
371:
367:
359:
354:
350:
346:
341:
335:11|11 B5
331:
327:
320:
313:
307:
300:
292:
288:
284:
279:
275:
270:
266:
258:
253:
249:
245:
240:
230:
226:
219:
212:
206:
199:
195:
189:
185:
181:
176:
172:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
123:
115:
110:
103:
98:
93:
82:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
2487:expanding it
2476:
2468:
2430:Translocases
2427:
2414:
2401:
2388:
2375:
2365:Transferases
2362:
2349:
2206:Binding site
2066:
1985:
1935:
1931:
1898:
1894:
1860:
1856:
1831:
1827:
1792:
1789:FEBS Letters
1788:
1757:
1753:
1719:(2): 150–7.
1716:
1712:
1678:
1674:
1641:
1637:
1577:
1573:
1563:
1518:
1514:
1474:
1470:
1464:
1423:
1419:
1409:
1376:
1372:
1362:
1353:
1344:
1335:
1326:
1251:
1222:racemization
1215:
1203:
1197:
1193:
1165:
1164:
1090:NP_001349673
1086:NP_001349672
1082:NP_001349671
1074:NP_001156783
1071:
1049:NP_001291732
1046:
1023:NM_001362744
1019:NM_001362743
1015:NM_001362742
1007:NM_001163311
1004:
982:NM_001304803
979:
955:
936:
910:
891:
865:
846:
826:
821:
742:human ageing
521:ciliary body
517:human kidney
489:right kidney
397:
390:
117:External IDs
72:
2201:Active site
2050:Amino acids
1834:(1): 62–7.
1675:NeuroReport
650:ATP binding
356:74,816,774
343:74,797,185
95:Identifiers
2526:Categories
2404:Isomerases
2378:Hydrolases
2245:Regulation
2029:Isomerases
1321:, May 2017
1300:, May 2017
1276:References
1185:enantiomer
767:metabolism
401:(ortholog)
255:2,325,260
242:2,303,383
138:HomoloGene
2479:isomerase
2283:EC number
1537:2296-889X
1440:1359-4184
1254:magnesium
1078:NP_038789
1053:NP_068766
1011:NM_013761
986:NM_021947
812:Orthologs
681:cytoplasm
146:GeneCards
2542:EC 4.3.1
2537:EC 5.1.1
2307:Kinetics
2231:Cofactor
2194:Activity
1952:15193426
1923:22811942
1915:15953485
1885:21820692
1877:20385472
1848:18812225
1819:43772379
1811:12560076
1776:16714286
1741:23387084
1733:16314870
1703:35663584
1695:16837850
1658:17067558
1614:12393813
1555:30918891
1491:11054547
1456:23387084
1448:16314870
1393:17067558
1317:–
1296:–
1230:pyruvate
1226:L-serine
1177:racemase
1173:5.1.1.18
1138:Wikidata
791:Sources:
431:testicle
2463:Biology
2417:Ligases
2187:Enzymes
2138:: Other
1992:PDBe-KB
1982:UniProt
1666:8142062
1582:Bibcode
1546:6424897
1401:8142062
1319:Ensembl
1298:Ensembl
1234:ammonia
1200:protein
1183:to its
924:UniProt
879:Ensembl
818:Species
797:QuickGO
701:cytosol
376:pattern
234:17p13.3
134:1351636
102:Aliases
2449:Portal
2391:Lyases
2136:5.1.99
1987:Q9GZT4
1973:(MeSH)
1950:
1921:
1913:
1883:
1875:
1846:
1817:
1809:
1774:
1739:
1731:
1701:
1693:
1664:
1656:
1612:
1605:137919
1602:
1553:
1543:
1535:
1489:
1454:
1446:
1438:
1399:
1391:
1181:serine
1124:search
1122:PubMed
957:Q9QZX7
938:Q9GZT4
834:Entrez
547:BioGPS
126:606477
2477:This
2343:Types
2104:5.1.3
2077:5.1.2
2046:5.1.1
1919:S2CID
1881:S2CID
1815:S2CID
1737:S2CID
1699:S2CID
1662:S2CID
1521:: 8.
1452:S2CID
1397:S2CID
1168:(SR,
867:27364
848:63826
827:Mouse
822:Human
793:Amigo
435:gonad
399:Mouse
392:Human
339:Start
274:Mouse
238:Start
171:Human
142:22775
2483:stub
2435:list
2428:EC7
2422:list
2415:EC6
2409:list
2402:EC5
2396:list
2389:EC4
2383:list
2376:EC3
2370:list
2363:EC2
2357:list
2350:EC1
2039:5.1)
1980:for
1948:PMID
1911:PMID
1873:PMID
1844:PMID
1807:PMID
1772:PMID
1729:PMID
1691:PMID
1654:PMID
1610:PMID
1551:PMID
1533:ISSN
1487:PMID
1471:Gene
1444:PMID
1436:ISSN
1389:PMID
1232:and
1207:gene
382:Bgee
330:Band
291:Chr.
229:Band
188:Chr.
122:OMIM
79:3L6R
75:3L6B
56:RCSB
53:PDBe
1978:PDB
1940:doi
1936:125
1903:doi
1865:doi
1861:120
1836:doi
1797:doi
1793:535
1762:doi
1758:281
1721:doi
1683:doi
1646:doi
1600:PMC
1590:doi
1541:PMC
1523:doi
1479:doi
1475:256
1428:doi
1381:doi
1258:ATP
1224:of
1204:SRR
555:n/a
352:End
251:End
154:OMA
150:SRR
130:MGI
109:SRR
46:PDB
22:SRR
2528::
2106::
2079::
2060::
2048::
2037:EC
2031::
1984::
1946:.
1934:.
1917:.
1909:.
1899:57
1897:.
1879:.
1871:.
1859:.
1842:.
1832:63
1830:.
1813:.
1805:.
1791:.
1787:.
1770:.
1756:.
1752:.
1735:.
1727:.
1717:11
1715:.
1697:.
1689:.
1679:17
1677:.
1660:.
1652:.
1642:61
1640:.
1636:.
1608:.
1598:.
1588:.
1578:99
1576:.
1572:.
1549:.
1539:.
1531:.
1517:.
1513:.
1499:^
1485:.
1473:.
1450:.
1442:.
1434:.
1424:11
1422:.
1418:.
1395:.
1387:.
1377:61
1375:.
1371:.
1352:.
1334:.
1305:^
1284:^
1213:.
1170:EC
795:/
358:bp
345:bp
257:bp
244:bp
152:;
148::
144:;
140::
136:;
132::
128:;
124::
77:,
2514:e
2507:t
2500:v
2489:.
2451::
2437:)
2433:(
2424:)
2420:(
2411:)
2407:(
2398:)
2394:(
2385:)
2381:(
2372:)
2368:(
2359:)
2355:(
2179:e
2172:t
2165:v
2035:(
2021:e
2014:t
2007:v
1994:.
1954:.
1942::
1925:.
1905::
1887:.
1867::
1850:.
1838::
1821:.
1799::
1778:.
1764::
1743:.
1723::
1705:.
1685::
1668:.
1648::
1616:.
1592::
1584::
1557:.
1525::
1519:6
1493:.
1481::
1458:.
1430::
1403:.
1383::
1356:.
1338:.
276:)
173:)
156::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
