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Sewall Wright

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726:. From 1915 to 1925 Wright was employed by the Animal Husbandry Division of the U.S. Bureau of Animal Husbandry. His main project was to investigate the inbreeding that had occurred in the artificial selection that resulted in the leading breeds of livestock used in American beef production. He also performed experiments with 80,000 guinea pigs in the study of physiological genetics. Furthermore he analyzed characters of some 40,000 guinea pigs in 23 strains of brother-sister matings against a random-bred stock. (Wright 1922a-c). The concentrated study of these two groups of mammals eventually led to the Shifting Balance Theory and the concept of "surfaces of selective value" in 1932. 564: 1656: 737:. An anecdote about Wright, disclaimed by Wright himself, describes a lecture during which Wright tucked an unruly guinea pig under his armpit, where he usually held a chalkboard eraser: according to the anecdote, at the conclusion of the lecture, Wright absent-mindedly began to erase the blackboard using the guinea pig. 1631: : accessed January 7, 2018), Sewall Wright, Chicago (Districts 0001-0250), Cook, Illinois, United States; citing enumeration district (ED) ED 208, sheet 11A, line 50, family 226, NARA microfilm publication T626 (Washington D.C.: National Archives and Records Administration, 2002), roll 423; FHL microfilm 2,340,158. 409:
Have you ever examined the gizzard of a fowl? The gizzard of a fowl is a deep red colar with blu at the top. First on the outside is a very thick muscle. Under this is a white and fleecy layer. Holding very tight to the other. I expect you know that chickens eat sand. The next two layers are rough
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Visualization of a fitness landscape. The X and Y axes represent continuous phenotypic traits, and the height at each point represents the corresponding organism's fitness. The arrows represent various mutational paths that the population could follow while evolving on the fitness
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would cause random wandering. He did not accept Fisher's genetic theory of dominance, but instead considered it to arise from biochemical considerations. Although set aside for many years, his interpretation is at the basis of modern ideas of dominance.
405:, and he published his last paper in 1988: he can be claimed, therefore, to be the scientist with the longest career of science writing. Wright's astonishing maturity at the age of seven may be judged from the following excerpt quoted in the obituary: 784:. He believed that the birth of the consciousness was not due to a mysterious property of increasing complexity, but rather an inherent property, therefore implying these properties were in the most elementary particles. 677:
of evolution. There has been much skepticism among evolutionary biologists as to whether these rather delicate conditions hold often in natural populations. Wright had a long-standing and bitter debate about this with
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and rumply. These layers hold the sand. They grind the food. One night when we had company we had chicken-pie. Our Aunt Polly cut open the gizzard, and in it we found a lot of grain, and some corn.
2513: 832:(2018) describes the contribution of Wright's work on path analysis and delays in its acceptance by several technical disciplines (specifically statistics and formal causal analysis). 6692: 44: 6727: 6722: 665:. In order to evolve to another, higher peak, the species would first have to pass through a valley of maladaptive intermediate stages. This could happen by 2609: 927: 1336:"The Wilhemine E. Key 2003 Invitational Lecture: Genetics: Alive and Well. The First Hundred Years as Viewed Through the Pages of the Journal of Heredity" 2892: 733:, and many of his students became influential in the development of mammalian genetics. He appreciated as early as 1917 that genes acted by controlling 1616:
They were married in Granville on September 10, 1921... The Wrights had two boys, Richard and Robert, during the remaining four years in Washington.
1575: : December 8, 2014), Sewall Wright and Louise Lane Williams, September 10, 1921; citing Licking, Ohio, reference 508B; FHL microfilm 384,312. 966: 2498: 624:
and the other evolutionary forces was important in the process of adaptation. He described the relationship between genotype or phenotype and
6672: 2566: 6702: 1672: 6667: 698:, is still widely used in social science. He was a hugely influential reviewer of manuscripts, as one of the most frequent reviewers for 524:
selected him as the Josiah Willards Gibbs lecturer for 1941. For his work on genetics of evolutionary processes, Wright was awarded the
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if the population is small enough. If a species was divided into small populations, some could find higher peaks. If there was some
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that arise from random births, deaths, and Mendelian segregations in reproduction. In this work he also introduced the concept of
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and Elizabeth Quincy Sewall Wright. His parents were first cousins, an interesting fact in light of Wright's later research on
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Steffes, David M (2007). "Panpsychic Organicism: Sewall Wright's Philosophy for Understanding Complex Genetic Systems".
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has been attributed to Sewall Wright and was first published in 1921. This metric is commonly employed to evaluate
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Wright married Louise Lane Williams (1895–1975) in 1921. They had three children: Richard, Robert, and Elizabeth.
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As a child, Wright helped his father and brother print and publish an early book of poems by his father's student
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Wright, Sewall (1960). "The Treatment of Reciprocal Interaction, with or without Lag, in Path Analysis".
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between the populations, these adaptations could spread to the rest of the species. This was Wright's
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that brought genetics and evolution together. Their work was essential to the contributions of
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Wright, Sewall (1926). "Effects of Age of Parents on Characteristics of the Guinea Pig".
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Evolution and the Genetics of Populations: Genetics and Biometric Foundations New Edition
813: 780:, who became a lifelong friend and philosophical collaborator. Wright endorsed a form of 753: 612:, which is sometimes known as the Sewall Wright effect, cumulative stochastic changes in 585: 422: 379: 307: 299: 128: 5478: 2448: 2153: 2094: 1093: 1038: 816:. The modern synthesis was the most important development in evolutionary biology after 6480: 6298: 6205: 6052: 5978: 5334: 5170: 5103: 5052: 4820: 4743: 4588: 4467: 4446: 4383: 4181: 4016: 3892: 3867: 3849: 3799: 3573: 3558: 3545: 3540: 3517: 3337: 3239: 3048: 2826: 2822: 2682: 2346: 2247: 2212: 2172: 2137: 2054: 2029: 2010: 1975: 1940: 1847: 1830: 1801: 1776: 1757: 1485: 1269: 1198: 1173: 1149: 1124: 777: 532: 461: 106: 86: 1913:
Fisher, R. A. (1929). "The Evolution of Dominance; Reply to Professor Sewall Wright".
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Wright, Sewall (1940). "Breeding Structure of Populations in Relation to Speciation".
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Wright, Sewall (1934). "Physiological and Evolutionary Theories of Dominance".
1792: 1140: 817: 723: 613: 449: 351: 350:, and along with Fisher he pioneered methods for computing the distribution of 335: 272: 148: 140: 2334: 1459: 6631: 6472: 6290: 6256: 6246: 6106: 6072: 5991: 5935: 5930: 5922: 5870: 5842: 5837: 5791: 5708: 5621: 5547: 5523: 5431: 5241: 5233: 5015: 5007: 4877: 4690: 4656: 4638: 4554: 4509: 4504: 4414: 4258: 4199: 4194: 4168: 4076: 4071: 3977: 3972: 3954: 3946: 3897: 3830: 3825: 3765: 3739: 3419: 3401: 3373: 3305: 3285: 3142: 3099: 3032: 2963: 2771: 2727: 2433:"The roles of mutation, inbreeding, crossbreeding and selection in evolution" 2265:
Wright, Sewall (1960). "The genetics of vital characters of the guinea pig".
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Wright and Fisher, along with J.B.S. Haldane, were the key figures in the
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or neo-Darwinian synthesis. Wright was the inventor/discoverer of the
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Wright, Sewall (1930). "The Genetical Theory of Natural Selection".
401:. At the age of seven, in 1897, he wrote his first "book", entitled 2904: 2243: 2006: 1971: 1926: 1753: 1265: 711: 359: 323: 294:(December 21, 1889 – March 3, 1988) was an American 228: 43: 1627:"United States Census, 1930," database with images, FamilySearch ( 772:
Wright was one of the few geneticists of his time to venture into
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Allendorf, Fred W.; Luikart, Gordon H.; Aitken, Sally N. (2012).
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He was the oldest of three gifted brothers—the others being the
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Monad to Man: The Concept of Progress in Evolutionary Biology
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Wright, Sewall (January 1921). "Correlation and causation".
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Wright, S. (1988). "Surfaces of selective value revisited".
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Crow, J. F. (1988). "Sewall Wright (1889-1988) — Obituary".
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would lead to a population climbing the nearest peak, while
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until 1925, when he joined the Department of Zoology at the
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vol. 4, Variability within and Among Natural Populations.
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vol. 3, Experimental Results and Evolutionary Deductions.
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Members of the United States National Academy of Sciences
925:(1990). "Sewall Wright. 21 December 1889-3 March 1988". 2499:
Sewall Wright: Darwin's Successor—Evolutionary Theorist
1777:"Isolation by distance under diverse systems of mating" 1220: 553: 2138:"The Distribution of Gene Frequencies in Populations" 1958:
Wright, Sewall (1929). "The Evolution of Dominance".
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has as its icon a representation of Wright's Piebald
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between members of populations as a result of random
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Biographical Memoirs of Fellows of the Royal Society
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among populations as a result of the interaction of
2487:"Path Analysis in Genetic Epidemiology: A Critique" 318:, which was a major step in the development of the 2460: 2409: 1698: 1586: 6728:Presidents of the American Society of Naturalists 2916: 2522: 6629: 5201:Mathematical, statistical, and computer sciences 2404: 1629:https://familysearch.org/ark:/61903/1:1:XSTH-NZW 1573:https://familysearch.org/ark:/61903/1:1:XD4D-1CD 960: 958: 472:investigating the inheritance of coat colors in 2142:Proceedings of the National Academy of Sciences 2083:Proceedings of the National Academy of Sciences 620:. Wright was convinced that the interaction of 528:from the National Academy of Sciences in 1945. 2458: 2267:Journal of Cellular and Comparative Physiology 1509: 1239:. So were Darwin and his wife Emma (Wedgwood). 851: 596:. Their theoretical work is the origin of the 6723:Members of the American Philosophical Society 2886: 2560: 1903:, Chapter 7, section "Synthesis as Hardening" 955: 860:vol. 1, Genetic & Biometric Foundations. 640:or the average phenotypes of the population. 1224:Conservation and the Genetics of Populations 705: 2027: 440:and graduated in 1906. He then enrolled in 2893: 2879: 2567: 2553: 1125:"Sewall Wright and physiological genetics" 1075: 1073: 1071: 42: 2171: 2161: 2112: 2102: 2053: 1934: 1846: 1800: 1661:. Harvard University Press. p. 376. 1527: 1351: 1197: 1148: 1016: 1014: 1012: 468:with the pioneering mammalian geneticist 448:. He was influenced greatly by Professor 4610: 2079:"A test of Fisher's theory of dominance" 1824: 1822: 1820: 1705:. University of Chicago Press. pp.  1122: 767: 562: 3180: 2902:United States National Medal of Science 2574: 2534:MacTutor History of Mathematics Archive 2318: 1696: 1593:. University of Chicago Press. p.  1584: 1464:American Academy of Arts & Sciences 1382: 1068: 1021:Russell, Elizabeth S. (December 1989). 1020: 14: 6630: 2860:Index of evolutionary biology articles 2501:by Edric Lescouflair and James F. Crow 2430: 2412:Sewall Wright and Evolutionary Biology 2299: 2264: 2229: 2194: 2135: 1992: 1957: 1912: 1869: 1828: 1774: 1739: 1701:Sewall Wright and Evolutionary Biology 1544: 1286: 1251: 1247: 1245: 1009: 964: 652: 558: 452:, one of the first women to receive a 5730: 5729: 5199: 4609: 4123: 3179: 2915: 2874: 2548: 2398:Metaphysics and the Origin of Species 2363: 1884:10.1093/oxfordjournals.jhered.a103361 1817: 1305:10.1093/oxfordjournals.jhered.a107413 1174:"Sewall Wright's 'Systems of Mating'" 992:"Sewall Wright - American geneticist" 917: 915: 913: 729:He did major work on the genetics of 514:American Academy of Arts and Sciences 6673:Foreign members of the Royal Society 2368:. New York: Basic Books. p. 6. 1897:The Structure of Evolutionary Theory 1654: 1512:"Statistical genetics and evolution" 1333: 1287:Wright, Sewall (September 1, 1965). 1171: 1079: 921: 870:vol. 2, Theory of Gene Frequencies. 6703:National Medal of Science laureates 2076: 1242: 1039:10.1146/annurev.ge.23.120189.000245 554:Scientific achievements and credits 518:Foreign Member of the Royal Society 211:Foreign Member of the Royal Society 24: 6668:Fellows of the Econometric Society 2386: 2030:"The molecular-basis of dominance" 1848:10.1111/j.1558-5646.1948.tb02746.x 910: 661:was that organisms come to occupy 444:where his father taught, to study 298:known for his influential work on 25: 6744: 2492: 2453:Annals of Mathematical Statistics 2449:"The Method of Path Coefficients" 2322:Journal of the History of Biology 1334:Crow, J. F. (September 1, 2004). 1123:Crow, J. F.; Dove, W. F. (1987). 776:. He found a union of concept in 460:. Wright received his Ph.D. from 2302:Journal of Agricultural Research 1685:Wright worshipped as a Unitarian 685: 584:make him a principal founder of 394:college in Galesburg, Illinois. 6698:Modern synthesis (20th century) 2514:Works by or about Sewall Wright 2467:. University of Chicago Press. 2416:. University of Chicago Press. 2357: 2312: 2293: 2258: 2223: 2188: 2129: 2070: 2028:Kacser, H; Burns, J.A. (1981). 2021: 1986: 1951: 1906: 1890: 1863: 1768: 1733: 1690: 1655:Ruse, Michael (June 30, 2009). 1648: 1634: 1621: 1589:Wright and Evolutionary Biology 1578: 1565: 1529:10.1090/S0002-9904-1942-07641-5 1503: 1486:"American Mathematical Society" 1478: 1452: 1427: 1402: 1376: 1327: 1280: 965:Fowler, Glenn (March 4, 1988). 845: 690:Wright's statistical method of 586:theoretical population genetics 504:(1980). He was a member of the 486:University of Wisconsin–Madison 334:and methods of computing it in 27:American geneticist (1889–1988) 2660:Constructive neutral evolution 2509:American Philosophical Society 1214: 1165: 1116: 984: 856:. University of Chicago Press. 546:Sewall Wright worshipped as a 510:American Philosophical Society 478:U.S. Department of Agriculture 13: 1: 4124: 2917:Behavioral and social science 903: 740: 598:modern evolutionary synthesis 522:American Mathematical Society 2610:Fisher's fundamental theorem 1697:Provine, William B. (1989). 1585:Provine, William B. (1989). 1552:"Daniel Giraud Elliot Medal" 750:coefficient of determination 506:National Academy of Sciences 369: 269:Other academic advisors 125:Coefficient of determination 7: 2635:Coefficient of relationship 2046:10.1093/genetics/97.3-4.639 1385:"The Life of Sewall Wright" 1227:. John Wiley. p. 548. 1190:10.1093/genetics/143.4.1499 710:Wright strongly influenced 338:. He extended this work to 10: 6749: 5805:Subrahmanyan Chandrasekhar 2463:Evolution: Selected papers 2437:Proc. 6th Int. Cong. Genet 526:Daniel Giraud Elliot Medal 374:Sewall Wright was born in 366:and biochemical genetics. 342:, computing the amount of 180:Daniel Giraud Elliot Medal 6678:Bussey Institution alumni 6567: 6416: 6265: 6086: 5892: 5740: 5736: 5725: 5659: 5561: 5450: 5361: 5282: 5210: 5206: 5195: 5152: 5061: 4953: 4844: 4780:William Hayward Pickering 4725: 4620: 4616: 4605: 4531: 4423: 4277: 4153: 4134: 4130: 4119: 4030: 3839: 3653: 3471: 3327: 3190: 3186: 3175: 3132: 3073: 2985: 2945: 2926: 2922: 2911: 2855: 2790: 2764: 2726: 2701: 2668: 2630:Coefficient of inbreeding 2582: 2364:Pearl, Judea (May 2018). 2335:10.1007/s10739-006-9105-5 1027:Annual Review of Genetics 787: 706:Plant and animal breeding 657:Wright's explanation for 618:effective population size 538: 490:National Medal of Science 464:, where he worked at the 302:and also for his work on 278: 268: 256: 234: 224: 217: 191:National Medal of Science 174: 120: 94: 75: 53: 41: 34: 6229:Norman Foster Ramsey Jr. 5675:S. R. Srinivasa Varadhan 3306:Burrhus Frederic Skinner 2808:Evolutionary game theory 2590:Hardy–Weinberg principle 2539:University of St Andrews 2104:10.1073/pnas.88.24.11413 1793:10.1093/genetics/31.1.39 1141:10.1093/genetics/115.1.1 758:computational statistics 201:Thomas Hunt Morgan Medal 6718:20th-century biologists 6663:Evolutionary biologists 5540:Cathleen Synge Morawetz 3458:George Ledyard Stebbins 3379:James Augustine Shannon 2620:Shifting balance theory 2459:Wright, Sewall (1986). 2431:Wright, Sewall (1932). 2232:The American Naturalist 1995:The American Naturalist 1960:The American Naturalist 1915:The American Naturalist 1829:Wright, Sewall (1948). 1742:The American Naturalist 1642:"Sewall Wright Profile" 1510:Wright, Sewall (1942). 852:Wright, Sewall (1984). 675:shifting balance theory 634:evolutionary landscapes 247:University of Wisconsin 165:Shifting balance theory 6733:Theistic evolutionists 6713:Population geneticists 6688:Lombard College alumni 6653:American statisticians 5997:Joseph O. Hirschfelder 5984:Kenneth Sanborn Pitzer 4940:Harry George Drickamer 4886:Hans Wolfgang Liepmann 4560:M. Frederick Hawthorne 4434:John D. Baldeschwieler 3674:Daniel E. Koshland Jr. 3356:Earl W. Sutherland Jr. 2605:Linkage disequilibrium 2279:10.1002/jcp.1030560413 1389:Harvard Square Library 941:10.1098/rsbm.1990.0044 602:inbreeding coefficient 569: 412: 376:Melrose, Massachusetts 332:inbreeding coefficient 306:. He was a founder of 157:Inbreeding coefficient 103:University of Illinois 68:Melrose, Massachusetts 6588:Sylvester James Gates 5974:William Alfred Fowler 5956:Robert Rathbun Wilson 5769:Robert Burns Woodward 4581:Geraldine L. Richmond 4329:Howard E. Simmons Jr. 3612:Rosalyn Sussman Yalow 3541:Vernon B. Mountcastle 3397:Sterling B. Hendricks 3214:Marshall W. Nirenberg 3209:Theodosius Dobzhansky 3057:William Julius Wilson 2847:Quantitative genetics 2756:Balding–Nichols model 2741:Population bottleneck 2736:Small population size 2640:Selection coefficient 2163:10.1073/pnas.23.6.307 1516:Bull. Amer. Math. Soc 1353:10.1093/jhered/esh061 826:and Dana Mackenzie's 768:Wright and philosophy 716:quantitative genetics 566: 482:University of Chicago 470:William Ernest Castle 438:Galesburg High School 416:aeronautical engineer 407: 263:William Ernest Castle 239:University of Chicago 186:Weldon Memorial Prize 6559:Warren M. Washington 6523:Fay Ajzenberg-Selove 6432:Jeremiah P. Ostriker 6377:Martin Schwarzschild 6158:Solomon J. Buchsbaum 6150:J. Robert Schrieffer 6120:E. Margaret Burbidge 5964:Nicolaas Bloembergen 5941:Arie Jan Haagen-Smit 5820:Vladimir K. Zworykin 5572:John Griggs Thompson 5495:Martin David Kruskal 5335:Kurt Otto Friedrichs 4808:Erwin Wilhelm MĂĽller 4762:Ralph Brazelton Peck 4717:Jack St. Clair Kilby 4644:John Robinson Pierce 4611:Engineering sciences 4542:Jacqueline K. Barton 4397:George M. Whitesides 4316:Dudley R. Herschbach 4254:Richard B. Bernstein 4223:Walter H. Stockmayer 3771:Elizabeth F. Neufeld 3702:G. Evelyn Hutchinson 3592:Stanley Norman Cohen 3579:Rita Levi-Montalcini 3415:Keith Roberts Porter 3278:Alfred H. Sturtevant 3273:Michael Heidelberger 3245:Fritz Albert Lipmann 2718:Background selection 2705:on genomic variation 2703:Effects of selection 2655:Population structure 2525:Robertson, Edmund F. 2505:Sewall Wright Papers 2393:Ghiselin, Michael T. 1439:search.amphilsoc.org 1435:"APS Member History" 1383:Lescouflair, Edric. 1289:"Dr. Wilhelmine Key" 1172:Hill, W. G. (1996). 745:The creation of the 535:, on March 3, 1988. 476:. He worked for the 419:Theodore Paul Wright 330:. He discovered the 6683:History of genetics 6658:American Unitarians 6648:American biologists 6609:Shirley Ann Jackson 6528:Charles P. Slichter 6372:Marshall Rosenbluth 6364:Wallace S. Broecker 6317:Eugene M. Shoemaker 6078:Victor F. Weisskopf 6025:Herbert S. Gutowsky 6007:Edgar Bright Wilson 5848:George Kistiakowsky 5466:Stephen Cole Kleene 4977:George H. Heilmeier 4964:Mildred Dresselhaus 4855:Edward H. Heinemann 4785:Frederick E. Terman 4749:Richard T. Whitcomb 4670:Clarence L. Johnson 4631:Theodore von Kármán 4518:Stephen J. Benkovic 4497:Mostafa A. El-Sayed 4484:Marvin H. Caruthers 4439:Ralph F. Hirschmann 4379:Darleane C. Hoffman 4269:Harden M. McConnell 4210:Frank H. Westheimer 4022:Stanley B. Prusiner 3986:Robert J. Lefkowitz 3745:Howard Martin Temin 3602:Maurice R. Hilleman 3597:Joseph L. Goldstein 3536:Donald A. Henderson 3453:Earl Reece Stadtman 3438:Elizabeth C. Crosby 3402:Orville Alvin Vogel 3232:Donald D. Van Slyke 3181:Biological sciences 2837:Population genomics 2713:Genetic hitchhiking 2600:Identity by descent 2576:Population genetics 2523:O'Connor, John J.; 2154:1937PNAS...23..307W 2136:Wright, S. (1937). 2095:1991PNAS...8811413O 2089:(24): 11413–11415. 2077:Orr, H. A. (1991). 1872:Journal of Heredity 1340:Journal of Heredity 1293:Journal of Heredity 1094:1988Natur.332..492S 754:regression analyses 653:Evolutionary theory 559:Population genetics 423:political scientist 380:Philip Green Wright 308:population genetics 300:evolutionary theory 285:Sewall Green Wright 129:Population genetics 6481:G. Brent Dalrymple 6299:Arthur L. Schawlow 6206:James A. Van Allen 6097:Philip W. Anderson 6053:Richard P. Feynman 5979:Linus Carl Pauling 5614:Dennis P. Sullivan 5171:John B. Goodenough 5104:Edwin N. Lightfoot 5072:Yuan-Cheng B. Fung 5053:Kenneth N. Stevens 4821:Raymond D. Mindlin 4744:Harold E. Edgerton 4589:A. Paul Alivisatos 4468:Stephen J. Lippard 4447:Ernest R. Davidson 4384:Harold S. Johnston 4218:William S. Johnson 4182:George C. Pimentel 4017:Susan L. Lindquist 3999:Francis S. Collins 3893:Victor A. McKusick 3868:Francisco J. Ayala 3850:Nancy C. Andreasen 3800:Robert A. Weinberg 3574:Har Gobind Khorana 3559:Michael E. DeBakey 3546:George Emil Palade 3518:Wendell L. Roelofs 3508:Howard L. Bachrach 3338:Barbara McClintock 3240:Edward F. Knipling 2823:Landscape genetics 1775:Wright, S (1946). 1675:on January 7, 2018 1466:. February 9, 2023 971:The New York Times 778:Charles Hartshorne 638:allele frequencies 570: 533:Madison, Wisconsin 462:Harvard University 436:. Wright attended 107:Harvard University 87:Madison, Wisconsin 6625: 6624: 6621: 6620: 6617: 6616: 6554:Esther M. Conwell 6494:Robert N. Clayton 6486:Riccardo Giacconi 6450:Raymond Davis Jr. 6338:Albert Overhauser 6281:Edwin M. McMillan 6242:Arnold O. Beckman 6219:Paul Ching-Wu Chu 6196:Paul C. Lauterbur 6173:Robert Hofstadter 6125:Maurice Goldhaber 6112:Charles H. Townes 6063:Edward M. Purcell 6030:Frederick Rossini 5884:Wolfgang Panofsky 5815:John H. Van Vleck 5731:Physical sciences 5721: 5720: 5717: 5716: 5683:Solomon W. Golomb 5643:Andrew J. Viterbi 5638:Leonard Kleinrock 5585:Calyampudi R. Rao 5553:Ronald R. Coifman 5461:George F. Carrier 5442:Donald C. Spencer 5437:Saunders Mac Lane 5372:Marshall H. Stone 5322:Shiing-Shen Chern 5229:Solomon Lefschetz 5191: 5190: 5187: 5186: 5128:David J. Wineland 5096:John M. Prausnitz 5037:C. Kumar N. Patel 5032:James L. Flanagan 5000:John Roy Whinnery 4987:H. Guyford Stever 4969:Nick Holonyak Jr. 4932:George W. Housner 4927:Willis M. Hawkins 4922:Daniel C. Drucker 4904:Robert Byron Bird 4896:Bernard M. Oliver 4803:Peter C. Goldmark 4790:Wernher von Braun 4736:George E. Mueller 4709:Nathan M. Newmark 4704:J. Presper Eckert 4683:Claude E. Shannon 4652:Charles S. Draper 4601: 4600: 4597: 4596: 4568:Judith P. Klinman 4452:Gábor A. Somorjai 4363:Isabella L. Karle 4350:George S. Hammond 4311:Gertrude B. Elion 4264:Rudolph A. Marcus 4115: 4114: 4111: 4110: 4041:Ralph L. Brinster 3960:Torsten N. Wiesel 3937:Norman E. Borlaug 3924:Solomon H. Snyder 3919:J. Michael Bishop 3878:Mario R. Capecchi 3758:Salome G. Waelsch 3689:E. Donnall Thomas 3564:Theodor O. Diener 3463:Paul Alfred Weiss 3291:Bernard B. Brodie 3227:George G. Simpson 3171: 3170: 3167: 3166: 3116:Michael I. Posner 3017:Eleanor J. Gibson 2969:George J. Stigler 2937:Neal Elgar Miller 2868: 2867: 2818:Genetic genealogy 2813:Fitness landscape 2474:978-0-226-91053-6 2423:978-0-226-68473-4 2401:. NY: SUNY Press. 2375:978-0-465-09760-9 1901:Stephen Jay Gould 1414:www.nasonline.org 1234:978-1-118-40857-5 642:Natural selection 403:Wonders of Nature 356:natural selection 282: 281: 252: 244: 219:Scientific career 145:Fitness landscape 64:December 21, 1889 16:(Redirected from 6740: 6437:Gilbert F. White 6382:George Wetherill 6276:Allan M. Cormack 6234:Jack Steinberger 6214:D. Allan Bromley 6163:H. Richard Crane 6140:Frederick Reines 6130:Helmut Landsberg 6045:George Uhlenbeck 5946:Vladimir Haensel 5908:Allan R. Sandage 5879:Herbert C. Brown 5861:Herbert Friedman 5787:Leon M. Lederman 5759:Julian Schwinger 5738: 5737: 5727: 5726: 5696:Alexandre Chorin 5670:Richard A. Tapia 5651:David B. Mumford 5479:Alberto CalderĂłn 5424:Joseph B. Keller 5411:Michael Freedman 5380:Herman Goldstine 5234:H. Marston Morse 5208: 5207: 5197: 5196: 5136:Rudolf E. Kálmán 5120:Robert S. Langer 5112:Jan D. Achenbach 4945:Herbert E. Grier 4696:Igor I. Sikorsky 4657:Othmar H. Ammann 4618: 4617: 4607: 4606: 4573:Jerrold Meinwald 4342:Norman Hackerman 4321:Glenn T. Seaborg 4236:William O. Baker 4164:F. Albert Cotton 4132: 4131: 4121: 4120: 4098:Mary-Claire King 3991:Bert W. O'Malley 3947:Thomas E. Starzl 3942:Phillip A. Sharp 3929:Charles Yanofsky 3911:Evelyn M. Witkin 3906:James E. Darnell 3732:Paul C. Zamecnik 3697:Mary Ellen Avery 3669:Herbert W. Boyer 3664:Baruj Benacerraf 3635:Joshua Lederberg 3625:Viktor Hamburger 3587:Michael S. Brown 3433:Robert H. Burris 3188: 3187: 3177: 3176: 3124:Mortimer Mishkin 3049:William K. Estes 3033:Roger N. Shepard 3025:Robert K. Merton 3009:George A. Miller 2956:Herbert A. Simon 2924: 2923: 2913: 2912: 2895: 2888: 2881: 2872: 2871: 2777:J. B. S. Haldane 2569: 2562: 2555: 2546: 2545: 2541: 2518:Internet Archive 2482: 2479:Internet Archive 2466: 2444: 2427: 2415: 2406:Provine, William 2380: 2379: 2361: 2355: 2354: 2316: 2310: 2309: 2297: 2291: 2290: 2262: 2256: 2255: 2238:(671): 552–559. 2227: 2221: 2220: 2192: 2186: 2185: 2175: 2165: 2133: 2127: 2126: 2116: 2106: 2074: 2068: 2067: 2057: 2040:(3–4): 639–666. 2025: 2019: 2018: 1990: 1984: 1983: 1966:(689): 556–561. 1955: 1949: 1948: 1938: 1921:(689): 553–556. 1910: 1904: 1894: 1888: 1887: 1867: 1861: 1860: 1850: 1826: 1815: 1814: 1804: 1772: 1766: 1765: 1748:(752): 232–248. 1737: 1731: 1730: 1725: 1723: 1704: 1694: 1688: 1687: 1682: 1680: 1671:. Archived from 1652: 1646: 1645: 1638: 1632: 1625: 1619: 1618: 1613: 1611: 1592: 1582: 1576: 1569: 1563: 1562: 1560: 1558: 1548: 1542: 1541: 1531: 1507: 1501: 1500: 1498: 1496: 1482: 1476: 1475: 1473: 1471: 1456: 1450: 1449: 1447: 1445: 1431: 1425: 1424: 1422: 1420: 1406: 1400: 1399: 1397: 1395: 1380: 1374: 1373: 1355: 1331: 1325: 1324: 1284: 1278: 1277: 1249: 1240: 1238: 1218: 1212: 1211: 1201: 1184:(4): 1499–1506. 1169: 1163: 1162: 1152: 1120: 1114: 1113: 1102:10.1038/332492a0 1077: 1066: 1065: 1063: 1061: 1018: 1007: 1006: 1004: 1002: 988: 982: 981: 979: 977: 962: 953: 952: 919: 857: 794:modern synthesis 762:machine learning 630:fitness surfaces 614:gene frequencies 594:J. B. S. Haldane 496:(1984), and the 466:Bussey Institute 352:gene frequencies 336:pedigree animals 320:modern synthesis 316:J. B. S. Haldane 258:Doctoral advisor 250: 242: 183: 116: 82: 63: 61: 46: 32: 31: 21: 18:Sewall G. Wright 6748: 6747: 6743: 6742: 6741: 6739: 6738: 6737: 6628: 6627: 6626: 6613: 6601:Sean C. Solomon 6563: 6515:Daniel Kleppner 6507:Lonnie Thompson 6502:Ralph A. Alpher 6468:W. Jason Morgan 6455:Charles Keeling 6445:Marvin L. Cohen 6412: 6395:John N. Bahcall 6390:Don L. Anderson 6356:Peter Goldreich 6309:Steven Weinberg 6261: 6191:Walter Elsasser 6168:Herman Feshbach 6082: 6020:Samuel Goudsmit 6012:Chien-Shiung Wu 5951:Frederick Seitz 5918:John A. Wheeler 5903:Robert H. Dicke 5888: 5751:Luis W. Alvarez 5732: 5713: 5701:David Blackwell 5655: 5606:Carl R. de Boor 5577:Karen Uhlenbeck 5557: 5511:Louis Nirenberg 5446: 5419:Ralph E. Gomory 5357: 5353:Donald E. Knuth 5340:Hassler Whitney 5278: 5202: 5183: 5148: 5080:Andreas Acrivos 5057: 5045:Eli Ruckenstein 5024:Hermann A. Haus 4995:Calvin F. Quate 4982:Luna B. Leopold 4949: 4840: 4826:Robert N. Noyce 4816:Emmett N. Leith 4775:Manson Benedict 4757:Rudolf Kompfner 4721: 4675:Warren K. Lewis 4612: 4593: 4527: 4489:Peter B. Dervan 4460:John I. Brauman 4419: 4371:Norman Davidson 4298:John D. Roberts 4273: 4241:Konrad E. Bloch 4187:Richard N. Zare 4149: 4126: 4107: 4064:Sallie Chisholm 4046:Rudolf Jaenisch 4026: 4009:J. Craig Venter 3968:Rita R. Colwell 3835: 3821:David Baltimore 3712:Robert W. Kates 3684:David G. Nathan 3679:Edward B. Lewis 3649: 3645:Harland G. Wood 3640:Roger W. Sperry 3495:Glenn W. Burton 3467: 3443:Arthur Kornberg 3410:Roger Guillemin 3387:Hallowell Davis 3351:Daniel I. Arnon 3343:Albert B. Sabin 3323: 3296:Detlev W. Bronk 3268:Harry F. Harlow 3263:Kenneth S. Cole 3250:William C. Rose 3222:Francis P. Rous 3182: 3163: 3128: 3108:Gordon H. Bower 3069: 3065:Robert M. Solow 2981: 2977:Milton Friedman 2941: 2918: 2907: 2899: 2869: 2864: 2851: 2786: 2760: 2722: 2706: 2704: 2697: 2664: 2595:Genetic linkage 2578: 2573: 2529:"Sewall Wright" 2495: 2475: 2424: 2389: 2387:Further reading 2384: 2383: 2376: 2366:The Book of Why 2362: 2358: 2317: 2313: 2298: 2294: 2263: 2259: 2228: 2224: 2209:10.2307/2527693 2193: 2189: 2134: 2130: 2075: 2071: 2026: 2022: 1991: 1987: 1956: 1952: 1911: 1907: 1895: 1891: 1868: 1864: 1827: 1818: 1773: 1769: 1738: 1734: 1721: 1719: 1717: 1695: 1691: 1678: 1676: 1669: 1653: 1649: 1640: 1639: 1635: 1626: 1622: 1609: 1607: 1605: 1583: 1579: 1570: 1566: 1556: 1554: 1550: 1549: 1545: 1508: 1504: 1494: 1492: 1484: 1483: 1479: 1469: 1467: 1460:"Sewall Wright" 1458: 1457: 1453: 1443: 1441: 1433: 1432: 1428: 1418: 1416: 1410:"Sewall Wright" 1408: 1407: 1403: 1393: 1391: 1381: 1377: 1332: 1328: 1285: 1281: 1250: 1243: 1235: 1219: 1215: 1170: 1166: 1121: 1117: 1078: 1069: 1059: 1057: 1019: 1010: 1000: 998: 990: 989: 985: 975: 973: 963: 956: 920: 911: 906: 848: 829:The Book of Why 790: 770: 743: 708: 696:graphical model 688: 655: 561: 556: 541: 442:Lombard College 388:Lombard College 372: 249: 245: 241: 209: 204: 199: 194: 189: 184: 178: 169:Threshold model 167: 163: 159: 155: 151: 147: 143: 139: 135: 131: 127: 110: 109: 105: 101: 99:Lombard College 95:Alma mater 90: 84: 80: 71: 65: 59: 57: 49: 37: 28: 23: 22: 15: 12: 11: 5: 6746: 6736: 6735: 6730: 6725: 6720: 6715: 6710: 6705: 6700: 6695: 6690: 6685: 6680: 6675: 6670: 6665: 6660: 6655: 6650: 6645: 6640: 6623: 6622: 6619: 6618: 6615: 6614: 6612: 6611: 6606: 6603: 6598: 6596:Burton Richter 6593: 6590: 6585: 6580: 6575: 6571: 6569: 6565: 6564: 6562: 6561: 6556: 6551: 6549:Yakir Aharonov 6546: 6543: 6538: 6533: 6530: 6525: 6520: 6517: 6512: 6509: 6504: 6499: 6496: 6491: 6488: 6483: 6478: 6475: 6470: 6465: 6463:Richard Garwin 6460: 6457: 6452: 6447: 6442: 6439: 6434: 6429: 6427:Willis E. Lamb 6424: 6420: 6418: 6414: 6413: 6411: 6410: 6405: 6400: 6397: 6392: 6387: 6384: 6379: 6374: 6369: 6366: 6361: 6358: 6353: 6348: 6345: 6340: 6335: 6332: 6327: 6322: 6319: 6314: 6311: 6306: 6301: 6296: 6293: 6288: 6283: 6278: 6273: 6269: 6267: 6263: 6262: 6260: 6259: 6254: 6249: 6244: 6239: 6236: 6231: 6226: 6221: 6216: 6211: 6208: 6203: 6198: 6193: 6188: 6186:Philip Abelson 6183: 6180: 6178:Chen-Ning Yang 6175: 6170: 6165: 6160: 6155: 6152: 6147: 6145:Bruno B. Rossi 6142: 6137: 6132: 6127: 6122: 6117: 6114: 6109: 6104: 6102:Yoichiro Nambu 6099: 6094: 6090: 6088: 6084: 6083: 6081: 6080: 6075: 6070: 6065: 6060: 6055: 6050: 6047: 6042: 6037: 6032: 6027: 6022: 6017: 6014: 6009: 6004: 5999: 5994: 5989: 5986: 5981: 5976: 5971: 5966: 5961: 5958: 5953: 5948: 5943: 5938: 5933: 5928: 5925: 5920: 5915: 5913:John C. Slater 5910: 5905: 5900: 5896: 5894: 5890: 5889: 5887: 5886: 5881: 5876: 5873: 5868: 5863: 5858: 5853: 5850: 5845: 5840: 5835: 5830: 5825: 5822: 5817: 5812: 5807: 5802: 5800:Jacob Bjerknes 5797: 5794: 5789: 5784: 5779: 5774: 5771: 5766: 5761: 5756: 5753: 5748: 5744: 5742: 5734: 5733: 5723: 5722: 5719: 5718: 5715: 5714: 5712: 5711: 5706: 5703: 5698: 5693: 5690: 5685: 5680: 5677: 5672: 5667: 5663: 5661: 5657: 5656: 5654: 5653: 5648: 5645: 5640: 5635: 5632: 5627: 5624: 5619: 5616: 5611: 5608: 5603: 5600: 5598:James G. Glimm 5595: 5592: 5590:Elias M. Stein 5587: 5582: 5579: 5574: 5569: 5565: 5563: 5559: 5558: 5556: 5555: 5550: 5545: 5542: 5537: 5534: 5532:Shing-Tung Yau 5529: 5526: 5521: 5516: 5513: 5508: 5505: 5500: 5497: 5492: 5489: 5484: 5481: 5476: 5473: 5468: 5463: 5458: 5454: 5452: 5448: 5447: 5445: 5444: 5439: 5434: 5429: 5426: 5421: 5416: 5413: 5408: 5403: 5400: 5398:Antoni Zygmund 5395: 5390: 5387: 5385:Isadore Singer 5382: 5377: 5374: 5369: 5365: 5363: 5359: 5358: 5356: 5355: 5350: 5348:Joseph L. Doob 5345: 5342: 5337: 5332: 5329: 5327:George Dantzig 5324: 5319: 5317:John W. Backus 5314: 5311: 5306: 5303: 5298: 5295: 5293:Richard Brauer 5290: 5286: 5284: 5280: 5279: 5277: 5276: 5274:William Feller 5271: 5268: 5263: 5260: 5255: 5252: 5247: 5244: 5239: 5236: 5231: 5226: 5223: 5221:Norbert Wiener 5218: 5214: 5212: 5204: 5203: 5193: 5192: 5189: 5188: 5185: 5184: 5182: 5181: 5179:Thomas Kailath 5176: 5173: 5168: 5165: 5160: 5156: 5154: 5150: 5149: 5147: 5146: 5141: 5138: 5133: 5130: 5125: 5122: 5117: 5114: 5109: 5106: 5101: 5098: 5093: 5090: 5085: 5082: 5077: 5074: 5069: 5065: 5063: 5059: 5058: 5056: 5055: 5050: 5047: 5042: 5039: 5034: 5029: 5026: 5021: 5018: 5013: 5010: 5005: 5002: 4997: 4992: 4989: 4984: 4979: 4974: 4971: 4966: 4961: 4957: 4955: 4951: 4950: 4948: 4947: 4942: 4937: 4934: 4929: 4924: 4919: 4916: 4911: 4909:H. Bolton Seed 4906: 4901: 4898: 4893: 4888: 4883: 4880: 4875: 4870: 4865: 4862: 4860:Donald L. Katz 4857: 4852: 4848: 4846: 4842: 4841: 4839: 4838: 4833: 4831:Earl R. Parker 4828: 4823: 4818: 4813: 4810: 4805: 4800: 4795: 4792: 4787: 4782: 4777: 4772: 4769: 4764: 4759: 4754: 4751: 4746: 4741: 4738: 4733: 4729: 4727: 4723: 4722: 4720: 4719: 4714: 4711: 4706: 4701: 4698: 4693: 4688: 4685: 4680: 4677: 4672: 4667: 4665:Hugh L. Dryden 4662: 4659: 4654: 4649: 4646: 4641: 4636: 4633: 4628: 4624: 4622: 4614: 4613: 4603: 4602: 4599: 4598: 4595: 4594: 4592: 4591: 4586: 4583: 4578: 4575: 4570: 4565: 4562: 4557: 4552: 4549: 4547:Peter J. Stang 4544: 4539: 4535: 4533: 4529: 4528: 4526: 4525: 4523:Marye Anne Fox 4520: 4515: 4512: 4507: 4502: 4499: 4494: 4491: 4486: 4481: 4478: 4476:Tobin J. Marks 4473: 4470: 4465: 4462: 4457: 4454: 4449: 4444: 4441: 4436: 4431: 4427: 4425: 4421: 4420: 4418: 4417: 4412: 4407: 4405:Stuart A. Rice 4402: 4399: 4394: 4389: 4386: 4381: 4376: 4373: 4368: 4365: 4360: 4355: 4352: 4347: 4344: 4339: 4337:Donald J. Cram 4334: 4331: 4326: 4323: 4318: 4313: 4308: 4306:Ronald Breslow 4303: 4300: 4295: 4290: 4285: 4281: 4279: 4275: 4274: 4272: 4271: 4266: 4261: 4256: 4251: 4248: 4246:Elias J. Corey 4243: 4238: 4233: 4230: 4225: 4220: 4215: 4212: 4207: 4205:Carl S. Marvel 4202: 4197: 4192: 4189: 4184: 4179: 4177:Roald Hoffmann 4174: 4171: 4166: 4161: 4157: 4155: 4151: 4150: 4148: 4147: 4142: 4138: 4136: 4128: 4127: 4117: 4116: 4113: 4112: 4109: 4108: 4106: 4105: 4100: 4095: 4093:Stanley Falkow 4090: 4087: 4085:Rakesh K. Jain 4082: 4079: 4074: 4069: 4066: 4061: 4056: 4051: 4048: 4043: 4038: 4034: 4032: 4028: 4027: 4025: 4024: 4019: 4014: 4011: 4006: 4001: 3996: 3993: 3988: 3983: 3980: 3975: 3970: 3965: 3962: 3957: 3952: 3949: 3944: 3939: 3934: 3931: 3926: 3921: 3916: 3913: 3908: 3903: 3900: 3895: 3890: 3888:Gene E. Likens 3885: 3880: 3875: 3873:George F. Bass 3870: 3865: 3862: 3857: 3855:Peter H. Raven 3852: 3847: 3843: 3841: 3837: 3836: 3834: 3833: 3828: 3823: 3818: 3815: 3810: 3805: 3802: 3797: 3792: 3789: 3784: 3781: 3779:Alexander Rich 3776: 3773: 3768: 3763: 3760: 3755: 3753:Daniel Nathans 3750: 3747: 3742: 3737: 3734: 3729: 3727:Folke K. Skoog 3724: 3719: 3717:Salvador Luria 3714: 3709: 3707:Elvin A. Kabat 3704: 3699: 3694: 3691: 3686: 3681: 3676: 3671: 3666: 3661: 3657: 3655: 3651: 3650: 3648: 3647: 3642: 3637: 3632: 3627: 3622: 3620:Katherine Esau 3617: 3614: 3609: 3607:Eric R. Kandel 3604: 3599: 3594: 3589: 3584: 3581: 3576: 3571: 3566: 3561: 3556: 3553: 3551:Joan A. Steitz 3548: 3543: 3538: 3533: 3528: 3525: 3523:Berta Scharrer 3520: 3515: 3510: 3505: 3502: 3497: 3492: 3490:Seymour Benzer 3487: 3484: 3482:Philip Handler 3479: 3475: 3473: 3469: 3468: 3466: 3465: 3460: 3455: 3450: 3445: 3440: 3435: 3430: 3427: 3422: 3417: 3412: 3407: 3404: 3399: 3394: 3389: 3384: 3381: 3376: 3371: 3369:Erwin Chargaff 3366: 3364:Britton Chance 3361: 3358: 3353: 3348: 3345: 3340: 3335: 3331: 3329: 3325: 3324: 3322: 3321: 3316: 3314:Robert Huebner 3311: 3308: 3303: 3298: 3293: 3288: 3283: 3280: 3275: 3270: 3265: 3260: 3257: 3252: 3247: 3242: 3237: 3234: 3229: 3224: 3219: 3216: 3211: 3206: 3203: 3201:C. B. van Niel 3198: 3194: 3192: 3184: 3183: 3173: 3172: 3169: 3168: 3165: 3164: 3162: 3161: 3159:Albert Bandura 3156: 3153: 3151:Robert Axelrod 3148: 3145: 3140: 3136: 3134: 3130: 3129: 3127: 3126: 3121: 3118: 3113: 3110: 3105: 3102: 3097: 3094: 3092:R. Duncan Luce 3089: 3086: 3081: 3077: 3075: 3071: 3070: 3068: 3067: 3062: 3059: 3054: 3051: 3046: 3043: 3041:Paul Samuelson 3038: 3035: 3030: 3027: 3022: 3019: 3014: 3011: 3006: 3003: 3001:Patrick Suppes 2998: 2996:Leonid Hurwicz 2993: 2989: 2987: 2983: 2982: 2980: 2979: 2974: 2971: 2966: 2961: 2958: 2953: 2949: 2947: 2943: 2942: 2940: 2939: 2934: 2930: 2928: 2920: 2919: 2909: 2908: 2898: 2897: 2890: 2883: 2875: 2866: 2865: 2863: 2862: 2856: 2853: 2852: 2850: 2849: 2844: 2842:Phylogeography 2839: 2834: 2832:Microevolution 2829: 2820: 2815: 2810: 2805: 2800: 2794: 2792: 2791:Related topics 2788: 2787: 2785: 2784: 2779: 2774: 2768: 2766: 2762: 2761: 2759: 2758: 2753: 2748: 2746:Founder effect 2743: 2738: 2732: 2730: 2724: 2723: 2721: 2720: 2715: 2709: 2707: 2702: 2699: 2698: 2696: 2695: 2690: 2685: 2680: 2674: 2672: 2666: 2665: 2663: 2662: 2657: 2652: 2647: 2642: 2637: 2632: 2627: 2625:Price equation 2622: 2617: 2615:Neutral theory 2612: 2607: 2602: 2597: 2592: 2586: 2584: 2580: 2579: 2572: 2571: 2564: 2557: 2549: 2543: 2542: 2520: 2511: 2502: 2494: 2493:External links 2491: 2490: 2489: 2483: 2473: 2456: 2445: 2428: 2422: 2402: 2388: 2385: 2382: 2381: 2374: 2356: 2329:(2): 327–361. 2311: 2292: 2257: 2244:10.1086/280125 2222: 2203:(3): 423–445. 2187: 2148:(6): 307–320. 2128: 2069: 2020: 2007:10.1086/280521 2001:(714): 24–53. 1985: 1972:10.1086/280290 1950: 1927:10.1086/280289 1905: 1889: 1878:(8): 349–356. 1862: 1841:(4): 279–294. 1816: 1767: 1754:10.1086/280891 1732: 1715: 1689: 1667: 1647: 1633: 1620: 1603: 1577: 1564: 1543: 1522:(4): 223–246. 1502: 1477: 1451: 1426: 1401: 1375: 1346:(5): 365–374. 1326: 1299:(5): 195–196. 1279: 1266:10.1086/284777 1241: 1233: 1213: 1164: 1115: 1067: 1008: 996:britannica.com 983: 954: 908: 907: 905: 902: 901: 900: 899: 898: 888: 878: 868: 847: 844: 789: 786: 769: 766: 742: 739: 724:plant breeding 707: 704: 687: 684: 663:adaptive peaks 654: 651: 578:mating systems 572:His papers on 560: 557: 555: 552: 540: 537: 450:Wilhelmine Key 371: 368: 280: 279: 276: 275: 273:Wilhelmine Key 270: 266: 265: 260: 254: 253: 236: 232: 231: 226: 222: 221: 215: 214: 176: 172: 171: 149:Genetic rescue 141:Fixation index 122: 121:Known for 118: 117: 96: 92: 91: 85: 83:(aged 98) 77: 73: 72: 66: 55: 51: 50: 48:Wright in 1954 47: 39: 38: 35: 26: 9: 6: 4: 3: 2: 6745: 6734: 6731: 6729: 6726: 6724: 6721: 6719: 6716: 6714: 6711: 6709: 6706: 6704: 6701: 6699: 6696: 6694: 6691: 6689: 6686: 6684: 6681: 6679: 6676: 6674: 6671: 6669: 6666: 6664: 6661: 6659: 6656: 6654: 6651: 6649: 6646: 6644: 6641: 6639: 6636: 6635: 6633: 6610: 6607: 6604: 6602: 6599: 6597: 6594: 6591: 6589: 6586: 6584: 6581: 6579: 6576: 6573: 6572: 6570: 6566: 6560: 6557: 6555: 6552: 6550: 6547: 6544: 6542: 6541:James E. Gunn 6539: 6537: 6534: 6531: 6529: 6526: 6524: 6521: 6518: 6516: 6513: 6510: 6508: 6505: 6503: 6500: 6497: 6495: 6492: 6489: 6487: 6484: 6482: 6479: 6476: 6474: 6473:Edward Witten 6471: 6469: 6466: 6464: 6461: 6458: 6456: 6453: 6451: 6448: 6446: 6443: 6440: 6438: 6435: 6433: 6430: 6428: 6425: 6422: 6421: 6419: 6415: 6409: 6406: 6404: 6401: 6398: 6396: 6393: 6391: 6388: 6385: 6383: 6380: 6378: 6375: 6373: 6370: 6367: 6365: 6362: 6359: 6357: 6354: 6352: 6349: 6346: 6344: 6341: 6339: 6336: 6333: 6331: 6328: 6326: 6323: 6320: 6318: 6315: 6312: 6310: 6307: 6305: 6302: 6300: 6297: 6294: 6292: 6291:Roger Revelle 6289: 6287: 6284: 6282: 6279: 6277: 6274: 6271: 6270: 6268: 6264: 6258: 6257:Henry Stommel 6255: 6253: 6250: 6248: 6247:Eugene Parker 6245: 6243: 6240: 6237: 6235: 6232: 6230: 6227: 6225: 6222: 6220: 6217: 6215: 6212: 6209: 6207: 6204: 6202: 6199: 6197: 6194: 6192: 6189: 6187: 6184: 6181: 6179: 6176: 6174: 6171: 6169: 6166: 6164: 6161: 6159: 6156: 6153: 6151: 6148: 6146: 6143: 6141: 6138: 6136: 6133: 6131: 6128: 6126: 6123: 6121: 6118: 6115: 6113: 6110: 6108: 6107:Edward Teller 6105: 6103: 6100: 6098: 6095: 6092: 6091: 6089: 6085: 6079: 6076: 6074: 6073:Lyman Spitzer 6071: 6069: 6066: 6064: 6061: 6059: 6056: 6054: 6051: 6048: 6046: 6043: 6041: 6038: 6036: 6033: 6031: 6028: 6026: 6023: 6021: 6018: 6015: 6013: 6010: 6008: 6005: 6003: 6000: 5998: 5995: 5993: 5992:Hans A. Bethe 5990: 5987: 5985: 5982: 5980: 5977: 5975: 5972: 5970: 5967: 5965: 5962: 5959: 5957: 5954: 5952: 5949: 5947: 5944: 5942: 5939: 5937: 5936:Maurice Ewing 5934: 5932: 5931:Carl Djerassi 5929: 5926: 5924: 5923:Saul Winstein 5921: 5919: 5916: 5914: 5911: 5909: 5906: 5904: 5901: 5898: 5897: 5895: 5891: 5885: 5882: 5880: 5877: 5874: 5872: 5871:Eugene Wigner 5869: 5867: 5864: 5862: 5859: 5857: 5856:Paul Bartlett 5854: 5851: 5849: 5846: 5844: 5843:Louis Hammett 5841: 5839: 5838:Gregory Breit 5836: 5834: 5833:Francis Birch 5831: 5829: 5826: 5823: 5821: 5818: 5816: 5813: 5811: 5808: 5806: 5803: 5801: 5798: 5795: 5793: 5792:William Rubey 5790: 5788: 5785: 5783: 5780: 5778: 5775: 5772: 5770: 5767: 5765: 5762: 5760: 5757: 5754: 5752: 5749: 5746: 5745: 5743: 5739: 5735: 5728: 5724: 5710: 5709:Michael Artin 5707: 5704: 5702: 5699: 5697: 5694: 5691: 5689: 5686: 5684: 5681: 5678: 5676: 5673: 5671: 5668: 5665: 5664: 5662: 5658: 5652: 5649: 5646: 5644: 5641: 5639: 5636: 5633: 5631: 5628: 5625: 5623: 5622:Bradley Efron 5620: 5617: 5615: 5612: 5609: 5607: 5604: 5601: 5599: 5596: 5593: 5591: 5588: 5586: 5583: 5580: 5578: 5575: 5573: 5570: 5567: 5566: 5564: 5560: 5554: 5551: 5549: 5548:Felix Browder 5546: 5543: 5541: 5538: 5535: 5533: 5530: 5527: 5525: 5524:Stephen Smale 5522: 5520: 5517: 5514: 5512: 5509: 5506: 5504: 5501: 5498: 5496: 5493: 5490: 5488: 5485: 5482: 5480: 5477: 5474: 5472: 5471:John McCarthy 5469: 5467: 5464: 5462: 5459: 5456: 5455: 5453: 5449: 5443: 5440: 5438: 5435: 5433: 5432:Samuel Karlin 5430: 5427: 5425: 5422: 5420: 5417: 5414: 5412: 5409: 5407: 5404: 5401: 5399: 5396: 5394: 5391: 5388: 5386: 5383: 5381: 5378: 5375: 5373: 5370: 5367: 5366: 5364: 5360: 5354: 5351: 5349: 5346: 5343: 5341: 5338: 5336: 5333: 5330: 5328: 5325: 5323: 5320: 5318: 5315: 5312: 5310: 5307: 5304: 5302: 5299: 5296: 5294: 5291: 5288: 5287: 5285: 5281: 5275: 5272: 5269: 5267: 5264: 5261: 5259: 5256: 5253: 5251: 5248: 5245: 5243: 5242:Oscar Zariski 5240: 5237: 5235: 5232: 5230: 5227: 5224: 5222: 5219: 5216: 5215: 5213: 5209: 5205: 5198: 5194: 5180: 5177: 5174: 5172: 5169: 5166: 5164: 5161: 5158: 5157: 5155: 5151: 5145: 5142: 5139: 5137: 5134: 5131: 5129: 5126: 5123: 5121: 5118: 5115: 5113: 5110: 5107: 5105: 5102: 5099: 5097: 5094: 5091: 5089: 5086: 5083: 5081: 5078: 5075: 5073: 5070: 5067: 5066: 5064: 5060: 5054: 5051: 5048: 5046: 5043: 5040: 5038: 5035: 5033: 5030: 5027: 5025: 5022: 5019: 5017: 5016:Ray W. Clough 5014: 5011: 5009: 5008:Alfred Y. Cho 5006: 5003: 5001: 4998: 4996: 4993: 4990: 4988: 4985: 4983: 4980: 4978: 4975: 4972: 4970: 4967: 4965: 4962: 4959: 4958: 4956: 4952: 4946: 4943: 4941: 4938: 4935: 4933: 4930: 4928: 4925: 4923: 4920: 4917: 4915: 4912: 4910: 4907: 4905: 4902: 4899: 4897: 4894: 4892: 4889: 4887: 4884: 4881: 4879: 4878:John G. Trump 4876: 4874: 4871: 4869: 4866: 4863: 4861: 4858: 4856: 4853: 4850: 4849: 4847: 4843: 4837: 4834: 4832: 4829: 4827: 4824: 4822: 4819: 4817: 4814: 4811: 4809: 4806: 4804: 4801: 4799: 4796: 4793: 4791: 4788: 4786: 4783: 4781: 4778: 4776: 4773: 4770: 4768: 4765: 4763: 4760: 4758: 4755: 4752: 4750: 4747: 4745: 4742: 4739: 4737: 4734: 4731: 4730: 4728: 4724: 4718: 4715: 4712: 4710: 4707: 4705: 4702: 4699: 4697: 4694: 4692: 4691:Edwin H. Land 4689: 4686: 4684: 4681: 4678: 4676: 4673: 4671: 4668: 4666: 4663: 4660: 4658: 4655: 4653: 4650: 4647: 4645: 4642: 4640: 4639:Vannevar Bush 4637: 4634: 4632: 4629: 4626: 4625: 4623: 4619: 4615: 4608: 4604: 4590: 4587: 4584: 4582: 4579: 4576: 4574: 4571: 4569: 4566: 4563: 4561: 4558: 4556: 4555:Allen J. Bard 4553: 4550: 4548: 4545: 4543: 4540: 4537: 4536: 4534: 4530: 4524: 4521: 4519: 4516: 4513: 4511: 4510:JoAnne Stubbe 4508: 4506: 4505:Joanna Fowler 4503: 4500: 4498: 4495: 4492: 4490: 4487: 4485: 4482: 4479: 4477: 4474: 4471: 4469: 4466: 4463: 4461: 4458: 4455: 4453: 4450: 4448: 4445: 4442: 4440: 4437: 4435: 4432: 4429: 4428: 4426: 4422: 4416: 4415:Susan Solomon 4413: 4411: 4408: 4406: 4403: 4400: 4398: 4395: 4393: 4390: 4387: 4385: 4382: 4380: 4377: 4374: 4372: 4369: 4366: 4364: 4361: 4359: 4356: 4353: 4351: 4348: 4345: 4343: 4340: 4338: 4335: 4332: 4330: 4327: 4324: 4322: 4319: 4317: 4314: 4312: 4309: 4307: 4304: 4301: 4299: 4296: 4294: 4291: 4289: 4286: 4283: 4282: 4280: 4276: 4270: 4267: 4265: 4262: 4260: 4259:Melvin Calvin 4257: 4255: 4252: 4249: 4247: 4244: 4242: 4239: 4237: 4234: 4231: 4229: 4226: 4224: 4221: 4219: 4216: 4213: 4211: 4208: 4206: 4203: 4201: 4200:Yuan Tseh Lee 4198: 4196: 4195:Harry B. Gray 4193: 4190: 4188: 4185: 4183: 4180: 4178: 4175: 4172: 4170: 4169:Gilbert Stork 4167: 4165: 4162: 4159: 4158: 4156: 4152: 4146: 4143: 4140: 4139: 4137: 4133: 4129: 4122: 4118: 4104: 4101: 4099: 4096: 4094: 4091: 4088: 4086: 4083: 4080: 4078: 4077:Bruce Alberts 4075: 4073: 4072:May Berenbaum 4070: 4067: 4065: 4062: 4060: 4057: 4055: 4052: 4049: 4047: 4044: 4042: 4039: 4036: 4035: 4033: 4029: 4023: 4020: 4018: 4015: 4012: 4010: 4007: 4005: 4002: 4000: 3997: 3994: 3992: 3989: 3987: 3984: 3981: 3979: 3978:Lubert Stryer 3976: 3974: 3973:Nina Fedoroff 3971: 3969: 3966: 3963: 3961: 3958: 3956: 3955:Anthony Fauci 3953: 3950: 3948: 3945: 3943: 3940: 3938: 3935: 3932: 3930: 3927: 3925: 3922: 3920: 3917: 3914: 3912: 3909: 3907: 3904: 3901: 3899: 3898:Harold Varmus 3896: 3894: 3891: 3889: 3886: 3884: 3881: 3879: 3876: 3874: 3871: 3869: 3866: 3863: 3861: 3858: 3856: 3853: 3851: 3848: 3845: 3844: 3842: 3838: 3832: 3831:Lynn Margulis 3829: 3827: 3826:Jared Diamond 3824: 3822: 3819: 3816: 3814: 3811: 3809: 3806: 3803: 3801: 3798: 3796: 3793: 3790: 3788: 3785: 3782: 3780: 3777: 3774: 3772: 3769: 3767: 3766:Thomas Eisner 3764: 3761: 3759: 3756: 3754: 3751: 3748: 3746: 3743: 3741: 3740:Maxine Singer 3738: 3735: 3733: 3730: 3728: 3725: 3723: 3722:Paul A. Marks 3720: 3718: 3715: 3713: 3710: 3708: 3705: 3703: 3700: 3698: 3695: 3692: 3690: 3687: 3685: 3682: 3680: 3677: 3675: 3672: 3670: 3667: 3665: 3662: 3659: 3658: 3656: 3652: 3646: 3643: 3641: 3638: 3636: 3633: 3631: 3628: 3626: 3623: 3621: 3618: 3615: 3613: 3610: 3608: 3605: 3603: 3600: 3598: 3595: 3593: 3590: 3588: 3585: 3582: 3580: 3577: 3575: 3572: 3570: 3567: 3565: 3562: 3560: 3557: 3554: 3552: 3549: 3547: 3544: 3542: 3539: 3537: 3534: 3532: 3531:Stanley Cohen 3529: 3526: 3524: 3521: 3519: 3516: 3514: 3511: 3509: 3506: 3503: 3501: 3498: 3496: 3493: 3491: 3488: 3485: 3483: 3480: 3477: 3476: 3474: 3470: 3464: 3461: 3459: 3456: 3454: 3451: 3449: 3446: 3444: 3441: 3439: 3436: 3434: 3431: 3428: 3426: 3423: 3421: 3420:Efraim Racker 3418: 3416: 3413: 3411: 3408: 3405: 3403: 3400: 3398: 3395: 3393: 3390: 3388: 3385: 3382: 3380: 3377: 3375: 3374:James V. Neel 3372: 3370: 3367: 3365: 3362: 3359: 3357: 3354: 3352: 3349: 3346: 3344: 3341: 3339: 3336: 3333: 3332: 3330: 3326: 3320: 3317: 3315: 3312: 3309: 3307: 3304: 3302: 3299: 3297: 3294: 3292: 3289: 3287: 3286:Horace Barker 3284: 3281: 3279: 3276: 3274: 3271: 3269: 3266: 3264: 3261: 3258: 3256: 3255:Sewall Wright 3253: 3251: 3248: 3246: 3243: 3241: 3238: 3235: 3233: 3230: 3228: 3225: 3223: 3220: 3217: 3215: 3212: 3210: 3207: 3204: 3202: 3199: 3196: 3195: 3193: 3189: 3185: 3178: 3174: 3160: 3157: 3154: 3152: 3149: 3146: 3144: 3143:Anne Treisman 3141: 3138: 3137: 3135: 3131: 3125: 3122: 3119: 3117: 3114: 3111: 3109: 3106: 3103: 3101: 3100:Kenneth Arrow 3098: 3095: 3093: 3090: 3087: 3085: 3082: 3079: 3078: 3076: 3072: 3066: 3063: 3060: 3058: 3055: 3052: 3050: 3047: 3044: 3042: 3039: 3036: 3034: 3031: 3028: 3026: 3023: 3020: 3018: 3015: 3012: 3010: 3007: 3004: 3002: 2999: 2997: 2994: 2991: 2990: 2988: 2984: 2978: 2975: 2972: 2970: 2967: 2965: 2964:Anne Anastasi 2962: 2959: 2957: 2954: 2951: 2950: 2948: 2944: 2938: 2935: 2932: 2931: 2929: 2925: 2921: 2914: 2910: 2906: 2903: 2896: 2891: 2889: 2884: 2882: 2877: 2876: 2873: 2861: 2858: 2857: 2854: 2848: 2845: 2843: 2840: 2838: 2835: 2833: 2830: 2828: 2824: 2821: 2819: 2816: 2814: 2811: 2809: 2806: 2804: 2801: 2799: 2796: 2795: 2793: 2789: 2783: 2782:Sewall Wright 2780: 2778: 2775: 2773: 2770: 2769: 2767: 2763: 2757: 2754: 2752: 2749: 2747: 2744: 2742: 2739: 2737: 2734: 2733: 2731: 2729: 2728:Genetic drift 2725: 2719: 2716: 2714: 2711: 2710: 2708: 2700: 2694: 2691: 2689: 2686: 2684: 2681: 2679: 2676: 2675: 2673: 2671: 2667: 2661: 2658: 2656: 2653: 2651: 2648: 2646: 2643: 2641: 2638: 2636: 2633: 2631: 2628: 2626: 2623: 2621: 2618: 2616: 2613: 2611: 2608: 2606: 2603: 2601: 2598: 2596: 2593: 2591: 2588: 2587: 2585: 2581: 2577: 2570: 2565: 2563: 2558: 2556: 2551: 2550: 2547: 2540: 2536: 2535: 2530: 2526: 2521: 2519: 2515: 2512: 2510: 2506: 2503: 2500: 2497: 2496: 2488: 2485:Wright 1983, 2484: 2480: 2476: 2470: 2465: 2464: 2457: 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1668:9780674042995 1664: 1660: 1659: 1651: 1643: 1637: 1630: 1624: 1617: 1606: 1604:9780226684734 1600: 1596: 1591: 1590: 1581: 1574: 1568: 1553: 1547: 1539: 1535: 1530: 1525: 1521: 1517: 1513: 1506: 1491: 1487: 1481: 1465: 1461: 1455: 1440: 1436: 1430: 1415: 1411: 1405: 1394:September 20, 1390: 1386: 1379: 1371: 1367: 1363: 1359: 1354: 1349: 1345: 1341: 1337: 1330: 1322: 1318: 1314: 1310: 1306: 1302: 1298: 1294: 1290: 1283: 1275: 1271: 1267: 1263: 1259: 1255: 1248: 1246: 1236: 1230: 1226: 1225: 1217: 1209: 1205: 1200: 1195: 1191: 1187: 1183: 1179: 1175: 1168: 1160: 1156: 1151: 1146: 1142: 1138: 1134: 1130: 1126: 1119: 1111: 1107: 1103: 1099: 1095: 1091: 1088:(6164): 492. 1087: 1083: 1076: 1074: 1072: 1056: 1052: 1048: 1044: 1040: 1036: 1032: 1028: 1024: 1017: 1015: 1013: 997: 993: 987: 972: 968: 961: 959: 950: 946: 942: 938: 934: 930: 929: 924: 918: 916: 914: 909: 897: 896:0-226-91041-5 893: 889: 887: 886:0-226-91040-7 883: 879: 877: 876:0-226-91039-3 873: 869: 867: 866:0-226-91038-5 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Cahn 4293:Karl Folkers 4054:Lucy Shapiro 4004:Elaine Fuchs 3883:Ann Graybiel 3813:Janet Rowley 3795:James Watson 3787:Ruth Patrick 3630:Philip Leder 3500:Mildred Cohn 3448:Severo Ochoa 3425:E. O. Wilson 3254: 2798:Biogeography 2781: 2772:R. A. Fisher 2650:Heritability 2583:Key concepts 2532: 2477:– via 2462: 2455:, 5: 161-215 2452: 2440: 2436: 2411: 2397: 2365: 2359: 2326: 2320: 2314: 2305: 2301: 2295: 2270: 2266: 2260: 2235: 2231: 2225: 2200: 2196: 2190: 2145: 2141: 2131: 2086: 2082: 2072: 2037: 2033: 2023: 1998: 1994: 1988: 1963: 1959: 1953: 1918: 1914: 1908: 1892: 1875: 1871: 1865: 1838: 1834: 1787:(1): 39–59. 1784: 1780: 1770: 1745: 1741: 1735: 1727: 1720:. Retrieved 1700: 1692: 1684: 1677:. Retrieved 1673:the original 1657: 1650: 1636: 1623: 1615: 1608:. Retrieved 1588: 1580: 1567: 1555:. Retrieved 1546: 1519: 1515: 1505: 1493:. Retrieved 1489: 1480: 1468:. Retrieved 1463: 1454: 1442:. Retrieved 1438: 1429: 1417:. Retrieved 1413: 1404: 1392:. 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Fisher 571: 545: 542: 530: 498:Darwin Medal 494:Balzan Prize 492:(1966), the 413: 408: 402: 396: 392:Universalist 373: 284: 283: 235:Institutions 218: 206:Balzan Prize 196:Darwin Medal 137:F-statistics 133:Causal graph 81:(1988-03-03) 29: 6708:Panpsychism 6643:1988 deaths 6638:1889 births 6536:Berni Alder 6343:Frank Press 6224:Walter Kohn 6201:George Pake 6135:Walter Munk 6058:Herman Mark 6040:Henry Taube 5828:Jesse Beams 5782:Peter Debye 5764:Harold Urey 5688:Barry Mazur 5250:John Milnor 5144:Amnon Yariv 5088:Leo Beranek 4914:Ernst Weber 4767:Abel Wolman 4358:Thomas Cech 4288:Elkan Blout 4228:Max Tishler 4145:Roger Adams 4103:Simon Levin 3569:Harry Eagle 3392:Paul Gyorgy 3084:Gary Becker 2751:Coalescence 2273:: 123–151. 1490:www.ams.org 1260:: 115–123. 1033:(1): 1–20. 935:: 568–579. 923:Hill, W. G. 824:Judea Pearl 782:panpsychism 747:statistical 731:guinea pigs 531:He died in 446:mathematics 430:mathematics 340:populations 251:(1955–1960) 243:(1926–1954) 6632:Categories 6330:Vera Rubin 5969:Paul Flory 5630:Hyman Bass 5503:John Cocke 5406:Raoul Bott 5309:Kurt Gödel 5301:John Tukey 5258:Paul Cohen 4873:George Low 4836:Simon Ramo 4059:Leroy Hood 3860:Carl Woese 3808:Bruce Ames 3319:Ernst Mayr 2693:Ecological 2683:Artificial 2443:: 356–366. 2308:: 557–585. 2197:Biometrics 1936:2440/15105 1899:(2002) by 1728:Unitarian. 1722:January 7, 1679:January 7, 1610:January 7, 1557:January 7, 1135:(1): 1–2. 904:References 840:Guinea Pig 798:Dobzhansky 774:philosophy 741:Statistics 574:inbreeding 568:landscape. 384:inbreeding 344:inbreeding 322:combining 310:alongside 296:geneticist 60:1889-12-21 6325:Val Fitch 5393:Peter Lax 5163:Shu Chien 4410:John Ross 4125:Chemistry 3513:Paul Berg 2905:laureates 2803:Evolution 2670:Selection 1835:Evolution 1495:March 21, 1362:0022-1503 1313:1465-7333 1047:0066-4197 1001:March 21, 671:gene flow 548:Unitarian 370:Biography 364:mammalian 328:evolution 290:Honorary 288:FRS (For) 6304:Ed Stone 3301:Jay Lush 2827:genomics 2765:Founders 2408:(1986). 2343:18175605 2287:13786823 2252:84805740 2182:16577780 2034:Genetics 2015:84400871 1980:85301374 1945:84667207 1857:18104586 1811:21009706 1781:Genetics 1762:84048953 1470:June 26, 1444:June 26, 1419:June 26, 1370:15388764 1274:85397524 1178:Genetics 1129:Genetics 1060:March 1, 949:11616179 814:Stebbins 712:Jay Lush 700:Genetics 516:, and a 421:and the 360:mutation 324:genetics 229:Genetics 2678:Natural 2645:Fitness 2516:at the 2507:at the 2395:(1997) 2351:3255830 2217:2527693 2173:1076930 2150:Bibcode 2123:1763055 2091:Bibcode 2064:7297851 2055:1214416 1802:1209315 1709:, 497. 1538:0006700 1321:5323812 1254:Am. Nat 1208:8844140 1199:1207415 1159:3549442 1150:1203043 1110:3282168 1090:Bibcode 1055:2694927 976:May 18, 806:Simpson 735:enzymes 626:fitness 500:of the 474:mammals 458:biology 434:biology 208:(1984) 115:, 1915) 2688:Sexual 2471:  2420:  2372:  2349:  2341:  2285:  2250:  2215:  2180:  2170:  2121:  2111:  2062:  2052:  2013:  1978:  1943:  1855:  1809:  1799:  1760:  1713:  1665:  1601:  1536:  1368:  1360:  1319:  1311:  1272:  1231:  1206:  1196:  1157:  1147:  1108:  1082:Nature 1053:  1045:  947:  894:  884:  874:  864:  836:OpenMx 818:Darwin 812:, and 788:Legacy 720:animal 659:stasis 580:, and 539:Family 520:. 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Index

Sewall G. Wright

Melrose, Massachusetts
Madison, Wisconsin
Lombard College
University of Illinois
Harvard University
Sc.D.
Coefficient of determination
Population genetics
Causal graph
F-statistics
Fixation index
Fitness landscape
Genetic rescue
Genetic drift
Inbreeding coefficient
Path analysis
Shifting balance theory
Threshold model
Daniel Giraud Elliot Medal
Weldon Memorial Prize
National Medal of Science
Darwin Medal
Thomas Hunt Morgan Medal
Balzan Prize
Foreign Member of the Royal Society
Genetics
University of Chicago
University of Wisconsin

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