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296:. This damage forced a channel on mitochondria to open and made them less efficient in their production of energy, causing them to swell and leak essential chemicals – eventually causing the cell to die. To perform the experiments, Gandhi and colleagues turned human skin cells into stem cells, which were converted into
475:
Gilks, William P; Abou-Sleiman, Patrick M; Gandhi, Sonia; Jain, Shushant; Singleton, Andrew; Lees, Andrew J; Shaw, Karen; Bhatia, Kailash P; Bonifati, Vincenzo; Quinn, Niall P; Lynch, John (2005). "A common LRRK2 mutation in idiopathic
Parkinson's disease".
327:. In particular, Gandhi was interested in how the virus evolved throughout the course of the pandemic, how it impacted the nervous system and how it was transmitted between people. She was also involved with the
851:
Gandhi, Sonia; Wood-Kaczmar, Alison; Yao, Zhi; Plun-Favreau, Helene; Deas, Emma; Klupsch, Kristina; Downward, Julian; Latchman, David S.; Tabrizi, Sarah J.; Wood, Nicholas W.; Duchen, Michael R. (2009-03-13).
640:"Scientists unravel molecular mechanisms of Parkinson's disease: Detailed brain cell analysis has helped researchers uncover new mechanisms thought to underlie Parkinson's disease"
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292:. Gandhi and co-workers showed that clumps of alpha-synuclein can be toxic to neural function, damaging proteins on the surface of
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273:(iPSC) models of disease, with a focus on understanding how the aggregation of alpha-synuclein, a protein encoded by the
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185:, Gandhi was involved with the epidemiological investigations and testing efforts at the Francis Crick Institute.
253:
in 2009. In 2012 she was awarded a
Wellcome Trust intermediate clinical fellowship to study the misfolding of
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690:"Researchers begin trial of drug to slow progression of neurodegenerative condition Multiple System Atrophy"
741:
854:"PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death"
194:
362:
PINK1-Associated
Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death
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that could be investigated into the laboratory. She was part of a team who investigated the use of
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and mitochondrial physiology to study the behaviour of alpha-synuclein at the molecular level.
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449:""The toxic consequences of protein aggregation in Parkinson's disease""
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177:. Her research investigates the molecular mechanisms that give rise to
301:
767:"UK unlikely to hit 100,000-a-day virus test target, warn experts"
205:(BM BCh) degree in medicine. She was a trainee neurologist at the
850:
405:
111:
555:"Grants awarded: Intermediate Clinical Fellowships | Wellcome"
312:(MRC) clinical fellowship to study the fundamental origins of
197:, and earned her bachelor's degree in 1996. She moved to the
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348:
A common LRRK2 mutation in idiopathic
Parkinson's disease
230:
166:
is a
British physician and neuroscientist who leads the
663:
Institute, UK DRI: UK Dementia
Research (2020-06-01).
794:"Mechanism of Oxidative Stress in Neurodegeneration"
590:Michael J. Fox Foundation for Parkinson's Research
355:Mechanism of Oxidative Stress in Neurodegeneration
269:in 2013. Her research group develop human-derived
765:Hughes, Laura; Hodgson, Camilla (16 April 2020).
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211:National Hospital for Neurology and Neurosurgery
288:In 2016 Gandhi was awarded a secondment at the
221:fellowship to work toward a doctoral degree in
173:laboratory. She holds a joint position at the
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265:. Gandhi established her laboratory at the
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936:21st-century British women medical doctors
792:Gandhi, Sonia; Abramov, Andrey Y. (2012).
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798:Oxidative Medicine and Cellular Longevity
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308:. In February 2020 Gandhi was awarded a
203:Bachelor of Medicine, Bachelor of Surgery
956:Academics of the Francis Crick Institute
715:"Dr Sonia Gandhi awarded new fellowship"
611:"Dr Sonia Gandhi awarded new fellowship"
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118:The role of PINK1 in Parkinson's disease
267:UCL Queen Square Institute of Neurology
227:UCL Queen Square Institute of Neurology
175:UCL Queen Square Institute of Neurology
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304:as a means to slow the progression of
243:National Institute for Health Research
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323:, Gandhi studied the epidemiology of
951:Alumni of Trinity College, Cambridge
931:21st-century British medical doctors
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16:British physician and neuroscientist
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946:Alumni of the University of Oxford
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742:"Coronavirus (COVID-19) research"
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453:Oxford Parkinson's Disease Centre
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261:, and how this misfolding causes
961:British people of Indian descent
671:. UK Dementia Research Institute
941:Parkinson's disease researchers
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665:"UK DRI: UK Dementia Research…"
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343:Gandhi's publications include:
193:Gandhi studied neuroscience at
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520:
441:
1:
926:British women neuroscientists
490:10.1016/S0140-6736(05)17830-1
367:
271:induced pluripotent stem cell
870:10.1016/j.molcel.2009.02.013
404:publications indexed by the
217:. In 2004 she was awarded a
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10:
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195:Trinity College, Cambridge
18:
132:
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93:University College London
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68:
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53:University College London
35:
28:
408:bibliographic database.
310:Medical Research Council
189:Early life and education
19:For the politician, see
921:British neuroscientists
410:(subscription required)
333:Francis Crick Institute
331:that took place at the
306:multiple system atrophy
290:Francis Crick Institute
251:Imperial College London
168:Francis Crick Institute
102:Imperial College London
97:Francis Crick Institute
43:University of Cambridge
388:Europe PubMed Central
339:Selected publications
283:single-molecule FRET
229:, and completed her
215:Whittington Hospital
207:Hammersmith Hospital
199:University of Oxford
48:University of Oxford
811:10.1155/2012/428010
582:"Sonia Gandhi, PhD"
325:coronavirus disease
314:Parkinson's disease
281:. She makes use of
259:Parkinson's disease
237:Research and career
179:Parkinson's disease
81:Parkinson's disease
713:UCL (2020-02-21).
609:UCL (2020-02-21).
386:publications from
241:She was awarded a
148:/find-a-researcher
73:Protein misfolding
484:(9457): 415–416.
425:"Dr Sonia Gandhi"
321:COVID-19 pandemic
183:COVID-19 pandemic
171:neurodegeneration
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77:Neurodegeneration
63:Scientific career
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559:wellcome.ac.uk
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644:ScienceDaily
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384:Sonia Gandhi
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294:mitochondria
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223:neuroscience
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87:Institutions
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30:Sonia Gandhi
21:Sonia Gandhi
746:crick.ac.uk
694:uclh.nhs.uk
669:ukdri.ac.uk
532:crick.ac.uk
319:During the
298:brain cells
247:lectureship
910:Categories
804:: 428010.
778:2020-06-01
751:2020-06-01
724:2020-06-01
699:2020-06-01
675:2020-06-01
649:2020-06-01
620:2020-06-01
595:2020-06-01
564:2020-06-01
537:2020-06-01
478:The Lancet
458:2020-06-01
434:2020-06-01
368:References
277:, impacts
233:in 2009.
878:1097-2765
820:1942-0900
615:ucl.ac.uk
498:0140-6736
302:exenatide
275:SNCA gene
146:/research
896:19285945
838:22685618
514:36186136
506:15680457
887:2724101
829:3362933
245:(NIHR)
225:at the
133:Website
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406:Scopus
140:.crick
123:(2009)
121:
112:Thesis
69:Fields
510:S2CID
892:PMID
874:ISSN
834:PMID
816:ISSN
802:2012
502:PMID
494:ISSN
213:and
882:PMC
866:doi
824:PMC
806:doi
486:doi
482:365
429:UCL
257:in
249:at
231:PhD
144:.uk
142:.ac
138:www
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