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320:: Since the spleen is important for protecting against encapsulated organisms, sepsis caused by encapsulated organisms is a possible complication of splenectomy. The option of partial splenectomy may be considered in the interest of preserving immune function. Research on outcomes is currently limited, but favorable.
265:
Spherocytosis can be diagnosed in
Peripheral blood film by seeing spherical red blood cells rather than biconcave. Because spherical red blood cells are more prone to lysis in water (because they lack some proteins in their cytoskeleton) there will be increased osmotic fragility on acidified glycerol
274:
Treatment may vary depending on the cause of the condition. In the case of hereditary spherocytosis, although research is ongoing, at this point there is no cure for the genetic defect that causes hereditary spherocytosis. Current management focuses on interventions that limit the severity of the
669:
Buesing, K. L.; Tracy, E. T.; Kiernan, C.; Pastor, A. C.; Cassidy, L. D.; Scott, J. P.; Ware, R. E.; Davidoff, A. M.; Rescorla, F. J.; Langer, J. C.; Rice, H. E.; Oldham, K. T. (2011). "Partial splenectomy for hereditary spherocytosis: A multi-institutional review".
625:
Bolton-Maggs, P. H. B.; Stevens, R. F.; Dodd, N. J.; Lamont, G.; Tittensor, P.; King, M. -J.; General
Haematology Task Force of the British Committee for Standards in Haematology (2004). "Guidelines for the diagnosis and management of hereditary spherocytosis".
120:). A complete blood count (CBC) may show increased reticulocytes, a sign of increased red blood cell production, and decreased hemoglobin and hematocrit. The term "non-hereditary spherocytosis" is occasionally used, albeit rarely.
226:. Because the cell skeleton has a defect, the blood cell contracts to a sphere, which is its most surface tension efficient and least flexible configuration. Though the spherocytes have a smaller surface area through which
1132:
577:
Bolton-Maggs PH, Stevens RF, Dodd NJ, Lamont G, Tittensor P, King MJ (August 2004). "Guidelines for the diagnosis and management of hereditary spherocytosis".
238:
fragility—when placed into water, they are more likely to burst than normal red blood cells. These cells are more prone to physical degradation.
116:
for old or damaged red blood cells and it thus constantly breaks them down, causing a cycle whereby the body destroys its own blood supply (auto-
740:
298:, the surgical removal of the spleen. Splenectomy is indicated for moderate to severe cases, but not mild cases. To decrease the risk of
80:) that are sphere-shaped rather than bi-concave disk shaped as normal. Spherocytes are found in all hemolytic anemias to some degree.
550:
Anthony S. Fauci; Eugene
Braunwald; Dennis L. Kasper; Stephen L. Hauser; Dan L. Longo; J. Larry Jameson; Joseph Loscalzo (2008).
314:, and prophylactic antibiotic treatment. However, the use of prophylactic antibiotics, such as penicillin, remains controversial.
410:
Thoma J, Kutter D, Casel S, et al. (2005). "HbSC hemoglobinopathy suspected by chest x-ray and red blood cell morphology".
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can be exchanged, they in themselves perform adequately to maintain healthy oxygen supplies. However, they have a high
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This article is about the presence of spheroid red blood cells. For the hereditary cause of this disorder, see
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and the latter would not. The misshapen but otherwise healthy red blood cells are mistaken by the
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Spherocytosis seen in a peripheral blood smear from a patient with hereditary spherocytosis
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Tkachuk, Douglas C.; Hirschmann, Jan V.; Wintrobe, Maxwell Myer, eds. (2007).
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556:(17th ed.). New York: McGraw-Hill Medical. pp. Chapter 106.
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Hematology in clinical practice: a guide to diagnosis and management
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disease. Treatment options for this type of spherocytosis include:
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is the presence of spherocytes in the blood, i.e. erythrocytes (
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202:. This is caused by a molecular defect in one or more of the
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Robert S. Hillman; Kenneth A. Ault; Henry M. Rinder (2005).
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In short, spherocytosis has an attribute of decreased cell
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Abnormal presence of spherical red blood cells in the blood
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282:: As in non-hereditary spherocytosis, acute symptoms of
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Mohandas, Narla; Gallagher, Patrick G. (2008-11-15).
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Intravenous water infusion or drowning (fresh water)
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294:indicate dietary supplementation of folic acid and
290:or exchanges and chronic symptoms of anemia and an
1133:Abnormal clinical and laboratory findings for RBCs
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100:Spherocytes are found in immunologically-mediated
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286:and hyperbilirubinemia indicate treatment with
490:"Red cell membrane: past, present, and future"
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382:. McGraw-Hill Professional. pp. 146–.
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553:Harrison's principles of internal medicine
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456:Wintrobe's atlas of clinical hematology
108:, but the former would have a positive
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714:Hereditary Spherocytosis from Medscape
257:Spherocyte compared to other forms of
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709:A picture of spherocytes from Medline
306:virus, encapsulated bacteria such as
324:Surgical removal of the gallbladder
198:Spherocytosis most often refers to
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25:
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702:
640:10.1111/j.1365-2141.2004.05052.x
591:10.1111/j.1365-2141.2004.05052.x
133:Cold autoimmune hemolytic anemia
128:Warm autoimmune hemolytic anemia
157:Rh hemolytic disease of newborn
684:10.1016/j.jpedsurg.2010.09.090
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628:British Journal of Haematology
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137:paroxysmal cold hemoglobinuria
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153:hemolytic diseases of newborn
672:Journal of Pediatric Surgery
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88:are characterized by having
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86:autoimmune hemolytic anemia
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1128:Red blood cell disorders
1072:Critical green inclusion
863:Sickle cell/drepanocyte
835:Hereditary spherocytosis
308:Streptococcus pneumoniae
200:hereditary spherocytosis
162:Hereditary spherocytosis
106:hereditary spherocytosis
82:Hereditary spherocytosis
32:Hereditary spherocytosis
804:Membrane abnormalities
974:Red cell agglutination
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206:of the red blood cell
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1077:Alder–Reilly anomaly
931:Basophilic stippling
424:10.1179/acb.2005.057
1052:Pelger–Huët anomaly
1010:Reactive lymphocyte
936:Pappenheimer bodies
867:Sickle cell disease
357:Hereditary diseases
318:Partial splenectomy
900:Hypochromic anemia
288:blood transfusions
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141:Acute and delayed
110:direct Coombs test
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1067:Toxic vacuolation
1062:Toxic granulation
993:White blood cells
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500:(10): 3939–3948.
466:978-0-7817-7023-1
389:978-0-07-144035-6
326:may be necessary.
189:Rh-null phenotype
123:Lists of causes:
102:hemolytic anemias
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37:Medical condition
16:(Redirected from
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43:Spherocytosis
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1057:Döhle bodies
1045:Arneth count
1032:Granulocytes
895:Anisochromia
873:Stomatocyte
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784:Microcytosis
779:Macrocytosis
774:Anisocytosis
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393:. Retrieved
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208:cytoskeleton
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185:Hyposplenism
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1015:Smudge cell
1002:Lymphocytes
941:Cabot rings
854:Schistocyte
818:Elliptocyte
808:Acanthocyte
395:15 November
296:splenectomy
280:Splenectomy
224:Protein 4.2
180:Snake bites
146:transfusion
1122:Categories
1087:Left shift
969:Haemoconia
951:Heinz body
849:Echinocyte
830:Spherocyte
750:Blood film
363:References
67:Hematology
18:Spherocyte
859:Degmacyte
844:Dacrocyte
514:0006-4971
304:influenza
270:Treatment
249:Diagnosis
148:reactions
143:hemolytic
118:hemolysis
63:Specialty
1103:Auer rod
979:Rouleaux
813:Codocyte
752:findings
692:21238662
648:15287938
599:15287938
532:18988878
475:70866931
440:43340793
432:16502600
331:See also
212:spectrin
204:proteins
1138:Anemias
656:5870305
607:5870305
523:2582001
236:osmotic
216:ankyrin
104:and in
888:Colour
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337:Anemia
300:sepsis
284:anemia
228:oxygen
220:Band 3
114:spleen
96:Causes
1096:Other
962:Other
793:Shape
652:S2CID
603:S2CID
494:Blood
436:S2CID
342:Blood
222:, or
767:Size
688:PMID
644:PMID
595:PMID
558:ISBN
528:PMID
510:ISSN
471:OCLC
461:ISBN
428:PMID
397:2010
384:ISBN
310:and
230:and
151:ABO
90:only
84:and
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518:PMC
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