524:
another that they do not all affect all of the GPCR linked proteins; however, the similarities between the steroid hormones and between the receptors make plausible the argument that each receptor may respond to multiple steroid hormones or that each hormone could affect multiple receptors. This is contrary to the traditional model of having a unique receptor for each unique ligand.
599:(SHBG) is thought to mainly function as a transporter and reservoir for the estradiol and testosterone sex hormones. However it has also been demonstrated that SHBG can bind to a cell surface receptor (SHBG-R). The SHBG-R has not been completely characterized. A subset of steroids are able to bind to the SHBG/SHBG-R complex resulting in an activation of
528:
Trace Amine
Associated Receptor 1 (TAAR1) binds Thyroid hormone (though not technically steroid hormones, thyroid hormones can be grouped here because their receptors belong to the nuclear receptor superfamily). As an example of the effects of these GPCR-linked proteins consider GPR30. GPR30 binds estrogen, and upon binding estrogen this pathway activates
488:: Upon ligand binding, steroid hormone receptors translocate to the nucleus, where they bind to specific DNA sequences called hormone response elements (HREs) within the regulatory regions of target genes. This binding either activates or suppresses gene transcription, leading to changes in mRNA levels and ultimately protein synthesis.
514:
A new class of steroid hormone receptors has recently been elucidated and these new receptors are found on the cell membrane. New studies suggest that along with the well documented intracellular receptors that cell membrane receptors are present for several steroid hormones and that their cellular
426:
Type II receptors are located in the nucleus. Thus, their ligands pass through the cell membrane and cytoplasm and enter the nucleus where they activate the receptor without release of HSP. The activated receptor interacts with the hormone response element and the transcription process is initiated
527:
At least four different GPCR-linked proteins are known to respond to steroid hormones. G Protein-Coupled
Receptor 30 (GPR30) binds estrogen, Membrane Progestin Receptor (mPR) binds progesterone, G Protein-Coupled Receptor Family C Group 6 Member A (GPRC6A) binds androgens, and Thyroid Hormone and
523:
GPCR linked proteins most likely interact with steroid hormones through an amino acid consensus sequence traditionally thought of as a cholesterol recognition and interaction site. About a third of Class A GPCRs contain this sequence. The steroid hormones themselves are different enough from one
506:
4. Non-Genomic
Signaling: In addition to classical genomic actions, steroid hormone receptors can initiate rapid, non-genomic signaling pathways in the cytoplasm or at the cell membrane. These pathways involve activation of various protein kinases and other signaling molecules, leading to rapid
503:: Steroid hormone receptors can also induce changes in chromatin structure through the recruitment of chromatin remodeling complexes. This allows for accessibility of the transcriptional machinery to specific gene regulatory regions, facilitating or inhibiting gene transcription.
510:
5. Cross-Talk with Other
Signaling Pathways: Steroid hormone receptors can also interact with and modulate the activity of other signaling pathways, such as growth factor signaling pathways, thereby integrating hormonal and growth factor signals to regulate cellular processes.
491:
2. Transcriptional
Coactivators and Corepressors: Steroid hormone receptors recruit coactivator or corepressor proteins to the gene promoter regions, which modulate the activity of RNA polymerase and other transcriptional machinery, thereby influencing
158:(HSPs) which bind the receptor until the hormone is present. Upon binding by the hormone the receptor undergoes a conformational change releasing the HSP, and the receptor together with the bound hormone enter the nucleus to act upon transcription.
399:
Free (that is, unbound) steroids enter the cell cytoplasm and interact with their receptor. In this process heat shock protein is dissociated, and the activated receptor-ligand complex is translocated into the nucleus. It is also related to EAATs.
383:
Depending on their mechanism of action and subcellular distribution, nuclear receptors may be classified into at least two classes. Nuclear receptors that bind steroid hormones are all classified as type I receptors. Only type I receptors have a
1041:
Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schütz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, Evans RM. The nuclear receptor superfamily: the second decade. Cell. 1995 Dec 15;83(6):835-9. doi: 10.1016/0092-8674(95)90199-x. PMID
110:(AR): These receptors bind to androgens such as testosterone and dihydrotestosterone (DHT). They play key roles in the development and function of male reproductive organs, as well as in secondary sexual characteristics and muscle growth.
81:, leading to the activation or suppression of gene expression and subsequent cellular responses. This interaction is crucial for mediating the physiological effects of steroid hormones in various tissues and organs of the body.
96:(ER): There are two subtypes, ERα and ERβ, which bind to the hormone estrogen. They regulate gene expression in response to estrogen, playing essential roles in reproductive tissues, bone metabolism, and cardiovascular health.
103:(PR): PRs bind to the hormone progesterone and regulate gene expression in response to its signaling. They are critical for various reproductive processes, including menstruation, pregnancy, and mammary gland development.
117:(GR): GRs bind to glucocorticoids like cortisol and regulate gene expression in response to stress and metabolic signals. They are involved in processes such as immune response, metabolism, and stress adaptation.
644:
Dahlman-Wright K, Cavailles V, Fuqua SA, Jordan VC, Katzenellenbogen JA, Korach KS, Maggi A, Muramatsu M, Parker MG, Gustafsson JA (Dec 2006). "International Union of
Pharmacology. LXIV. Estrogen receptors".
957:
Luconi M, Francavilla F, Porazzi I, Macerola B, Forti G, Baldi E (Aug 2004). "Human spermatozoa as a model for studying membrane receptors mediating rapid nongenomic effects of progesterone and estrogens".
1794:
124:(MR): MRs primarily bind to mineralocorticoids such as aldosterone and regulate electrolyte balance and blood pressure by controlling ion transport in epithelial cells of the kidney and other tissues.
462:
There is some evidence that certain steroid hormone receptors can extend through lipid bilayer membranes at the surface of cells and might be able to interact with hormones that remain outside cells.
773:
Schwabe JW, Chapman L, Finch JT, Rhodes D (Nov 1993). "The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements".
744:
Thornton JW, Need E, Crews D. Resurrecting the ancestral steroid receptor: ancient origin of estrogen signaling. Science. 2003 Jul 4;301(5637):1714-7. doi: 10.1126/science.1086185. PMID 12805548.
690:"International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors"
1003:"Estrogen receptor (ER)alpha and ER beta are both expressed in human ejaculated spermatozoa: evidence of their direct interaction with phosphatidylinositol-3-OH kinase/Akt pathway"
1787:
369:. At the end of this domain is the C-terminal. The terminal connects the molecule to its pair in the homodimer or heterodimer. It may affect the magnitude of the response.
2716:
1577:
Strünker T, Goodwin N, Brenker C, Kashikar ND, Weyand I, Seifert R, Kaupp UB (Mar 2011). "The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm".
7394:
7206:
1780:
73:
A steroid hormone receptor is a protein molecule located either within the cell cytoplasm or nucleus that specifically binds to steroid hormones, such as estrogen,
7716:
3215:
688:
Lu NZ, Wardell SE, Burnstein KL, Defranco D, Fuller PJ, Giguere V, Hochberg RB, McKay L, Renoir JM, Weigel NL, Wilson EM, McDonnell DP, Cidlowski JA (Dec 2006).
7311:
1534:
Maurice T, Junien JL, Privat A (Feb 1997). "Dehydroepiandrosterone sulfate attenuates dizocilpine-induced learning impairment in mice via sigma 1-receptors".
7624:
7399:
7404:
689:
7326:
7601:
5422:
1457:
Puia G, Santi MR, Vicini S, Pritchett DB, Purdy RH, Paul SM, Seeburg PH, Costa E (May 1990). "Neurosteroids act on recombinant human GABAA receptors".
1406:
Hosie AM, Wilkins ME, da Silva HM, Smart TG (Nov 2006). "Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites".
317:: This centrally located highly conserved DNA binding domain (DBD) consists of two non-repetitive globular motifs where zinc is coordinated with four
7321:
7295:
150:
upon activation, or remain in the nucleus waiting for the steroid hormone to enter and activate them. This uptake into the nucleus is facilitated by
4100:
3122:
3117:
3112:
7667:
753:
Evans RM. The steroid and thyroid hormone receptor superfamily. Science. 1988 Nov 18;240(4859):889-95. doi: 10.1126/science.3283939. PMID 3283939.
7563:
2761:
388:(HSP) associated with the inactive receptor that will be released when the receptor interacts with the ligand. Type I receptors may be found in
7729:
7503:
7470:
2746:
2432:
7528:
7523:
7238:
7649:
7429:
3255:
7589:
7498:
7284:
7050:
7034:
1853:
1761:
7744:
7662:
3107:
1052:
Norman AW, Mizwicki MT, Norman DP (Jan 2004). "Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model".
304:
Intracellular steroid hormone receptors share a common structure of four units that are functionally homologous, so-called "domains":
7609:
7508:
7455:
5823:
5818:
5813:
5808:
5803:
2892:
2885:
2880:
2868:
2863:
2858:
2853:
2848:
2776:
873:
Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schütz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, Evans RM (Dec 1995).
7644:
7584:
7460:
7450:
7414:
7356:
6772:
4895:
7696:
7614:
7336:
5983:
5978:
5928:
5918:
5898:
5883:
5863:
5788:
5768:
4910:
4905:
3571:
353:, amino-acid sequences capable of binding chaperones and parts of dimerization interfaces. Such receptors are closely related to
396:
forms. Type II nuclear receptors have no HSP, and in contrast to the classical type I receptor are located in the cell nucleus.
7639:
7558:
7376:
7371:
7351:
7346:
5139:
5097:
5092:
5087:
5025:
4859:
4647:
4598:
4593:
2640:
2630:
465:
Steroid hormone receptors can also function outside the nucleus and couple to cytoplasmic signal transduction proteins such as
1704:
Rosner W, Hryb DJ, Kahn SM, Nakhla AM, Romas NA (Mar 2010). "Interactions of sex hormone-binding globulin with target cells".
7701:
7634:
7553:
7513:
7493:
7488:
7341:
7316:
7619:
7419:
7366:
6535:
2427:
1999:
7691:
7424:
6804:
5703:
3790:
1361:
Herd MB, Belelli D, Lambert JJ (Oct 2007). "Neurosteroid modulation of synaptic and extrasynaptic GABA(A) receptors".
7276:
7231:
3248:
3243:
3171:
3161:
2038:
2028:
1863:
1653:
Lishko PV, Botchkina IL, Kirichok Y (Mar 2011). "Progesterone activates the principal Ca2+ channel of human sperm".
7765:
7475:
7303:
3166:
3080:
532:
and epidermal growth factor receptor. It results in vasodilation, renoprotection, mammary gland development, etc.
7711:
7533:
6102:
3378:
3368:
1969:
1848:
584:
Ca channels. Since eggs release progesterone, sperm may use progesterone as a homing signal to swim toward eggs (
728:
507:
cellular responses such as ion fluxes, cytoskeletal rearrangements, and activation of second messenger systems.
7361:
3733:
3373:
3068:
604:
89:
Steroid hormone receptors can be categorized into several types based on their specific ligands and functions:
46:
which lead to changes in gene expression over a time period of hours to days. The best studied steroid hormone
7734:
7015:
7010:
6161:
3073:
7224:
7110:
5446:
3596:
3149:
3139:
596:
5615:
5610:
5161:
3238:
3156:
3144:
2220:
350:
151:
3351:
2349:
1765:
436:
234:
121:
59:
6767:
3648:
3633:
3616:
3611:
3606:
3601:
3512:
3487:
3363:
3275:
3265:
2422:
1895:
620:
581:
466:
1772:
7545:
6509:
6144:
5660:
5233:
5072:
4007:
4002:
3987:
3462:
3437:
3270:
3063:
2454:
1920:
1753:
577:
452:
416:
330:
1501:
7247:
6874:
4915:
4232:
3346:
3334:
1151:"Sensory coding mechanisms revealed by optical tagging of physiologically defined neuronal types"
217:
186:
114:
47:
7005:
5052:
5047:
3442:
3339:
3134:
3095:
2158:
1807:
199:
35:
311:: It begins at the N-terminal and is the most variable domain between the different receptors.
239:
222:
154:(NLS) found in the hinge region of the receptor. This region of the receptor is covered up by
7381:
6997:
6557:
3356:
3292:
3287:
3100:
2176:
1749:
1100:"G protein-coupled receptors: extranuclear mediators for the non-genomic actions of steroids"
540:
251:
204:
191:
100:
67:
1502:"Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor"
256:
6578:
6570:
4408:
3890:
3415:
3410:
3405:
3085:
2968:
1803:
1662:
1586:
1415:
1278:
1162:
829:
500:
412:
277:
139:
1001:
Aquila S, Sisci D, Gentile M, Middea E, Catalano S, Carpino A, Rago V, Andò S (Mar 2004).
8:
6892:
6596:
6292:
4495:
3700:
3282:
3260:
3233:
3195:
3129:
551:
354:
58:(group NR3A) and 3-ketosteroids (group NR3C). In addition to nuclear receptors, several
39:
1666:
1590:
1419:
1282:
1166:
833:
7254:
6430:
1729:
1686:
1610:
1559:
1482:
1439:
1370:
1299:
1266:
1242:
1215:
1196:
1183:
1150:
1126:
1099:
1077:
983:
899:
874:
850:
817:
798:
720:
670:
385:
155:
1547:
7573:
6012:
6003:
5640:
4588:
3329:
3324:
1721:
1678:
1602:
1551:
1516:
1474:
1470:
1431:
1388:
1384:
1343:
1304:
1247:
1216:"Integrated action of pheromone signals in promoting courtship behavior in male mice"
1200:
1188:
1131:
1069:
1024:
975:
939:
904:
890:
855:
790:
786:
763:
712:
662:
608:
481:
Steroid hormone receptors exert their effects through several mechanisms, including:
366:
272:
171:
107:
93:
1733:
1486:
1081:
987:
802:
724:
674:
4539:
4521:
3090:
3037:
2811:
1713:
1690:
1670:
1631:
1614:
1594:
1563:
1543:
1466:
1443:
1423:
1380:
1335:
1294:
1286:
1237:
1227:
1178:
1170:
1121:
1111:
1061:
1014:
971:
967:
931:
894:
886:
845:
837:
782:
704:
654:
625:
611:
steroid receptor that is capable of transmitting signals to the interior of cells.
600:
529:
162:
133:
51:
1324:"Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor"
329:. This region controls which gene will be activated. On DNA it interacts with the
325:
residues. Their secondary and tertiary structure is distinct from that of classic
6680:
5903:
5773:
4937:
922:
Novac N, Heinzel T (Dec 2004). "Nuclear receptors: overview and classification".
493:
485:
43:
31:
7216:
1267:"Physiology-forward identification of bile acid-sensitive vomeronasal receptors"
7251:
6777:
5057:
5040:
3183:
2838:
1835:
1265:
Wong WM, Cao J, Zhang X, Doyle WI, Mercado LL, Gautron L, Meeks JP (May 2020).
566:
555:
444:
1717:
7759:
5635:
4975:
3400:
3188:
2516:
935:
562:
448:
408:
365:), which are required to maintain their inactive (but receptive) cytoplasmic
1339:
1214:
Haga-Yamanaka S, Ma L, He J, Qiu Q, Lavis LD, Looger LL, Yu CR (July 2014).
1174:
841:
7185:
6497:
6380:
6372:
5743:
5699:
4702:
4550:
1725:
1682:
1606:
1435:
1392:
1308:
1290:
1251:
1192:
1135:
1073:
1028:
1019:
1002:
979:
943:
716:
666:
573:
286:
265:
147:
78:
74:
23:
1636:
1623:
1555:
1520:
1478:
1347:
1116:
908:
859:
794:
6869:
6472:
4952:
4667:
4632:
3021:
2826:
2821:
2264:
2068:
2063:
1959:
1839:
440:
393:
326:
282:
261:
244:
175:
63:
1674:
1598:
1427:
1232:
554:
bind to and modulate the activity of several ion channels including the
7262:
7181:
7132:
6604:
6208:
6117:
6097:
6070:
5417:
5166:
5015:
5003:
4998:
3997:
3992:
2756:
2751:
2729:
2595:
2413:
2117:
2058:
2053:
2033:
585:
536:
1322:
Majewska MD, Harrison NL, Schwartz RD, Barker JL, Paul SM (May 1986).
767:
708:
658:
142:. Depending upon the type of receptor, they are either located in the
7055:
7045:
7028:
6502:
6275:
5521:
3226:
2655:
2313:
1802:
607:
second messenger. Hence the SHBG/SHBG-R complex appears to act as a
389:
322:
1323:
1065:
6522:
4662:
3221:
3178:
2230:
1375:
318:
227:
179:
55:
7546:
6300:
643:
6922:
6902:
6897:
6609:
4583:
4367:
2279:
2274:
2269:
2257:
2252:
456:
339:: This area controls the movement of the receptor to the nucleus.
143:
27:
956:
7103:
7098:
7093:
7083:
7078:
6797:
6352:
6347:
6342:
6337:
5603:
5598:
5475:
5470:
5465:
5450:
5441:
5436:
5431:
5410:
5324:
5319:
5107:
5102:
5082:
5077:
5067:
5062:
4900:
4852:
4847:
4842:
4837:
4807:
4802:
4797:
4792:
4762:
4712:
4707:
4470:
4390:
4362:
4357:
4352:
4347:
4342:
4337:
4332:
4327:
4322:
4317:
4312:
4307:
4302:
4297:
4292:
4287:
4282:
4277:
4267:
4262:
4257:
4252:
4247:
4242:
4237:
4227:
4222:
4217:
4177:
4130:
4125:
4120:
4115:
4110:
4105:
4095:
4083:
4078:
3844:
3839:
3834:
3716:
3711:
3683:
3678:
3663:
3658:
3653:
3643:
3638:
3626:
3621:
2993:
2988:
2983:
2978:
2973:
2948:
2875:
2843:
2786:
2781:
2568:
2563:
2558:
2442:
2247:
2137:
2132:
2105:
2100:
2095:
2021:
872:
404:
346:
7602:
1576:
1321:
459:(as well as in the large bowel and possibly in sweat glands).
7439:
7382:
7147:
7125:
7120:
7088:
6977:
6972:
6917:
6912:
6907:
6851:
6760:
6755:
6750:
6745:
6740:
6735:
6730:
6725:
6673:
6668:
6656:
6651:
6646:
6641:
6629:
6624:
6619:
6614:
6583:
6550:
6545:
6540:
6487:
6482:
6477:
6452:
6410:
6405:
6400:
6395:
6390:
6385:
6357:
6310:
6305:
6251:
6246:
6241:
6236:
6213:
5988:
5973:
5968:
5963:
5958:
5953:
5948:
5943:
5938:
5933:
5923:
5913:
5908:
5893:
5888:
5878:
5873:
5868:
5858:
5853:
5848:
5843:
5838:
5833:
5828:
5798:
5793:
5783:
5778:
5763:
5758:
5753:
5748:
5682:
5677:
5672:
5645:
5620:
5588:
5581:
5576:
5482:
5460:
5455:
5427:
5405:
5400:
5395:
5390:
5285:
5280:
5225:
5218:
5213:
5198:
5171:
4832:
4827:
4822:
4817:
4812:
4787:
4782:
4777:
4772:
4767:
4757:
4752:
4747:
4742:
4737:
4732:
4727:
4722:
4717:
4697:
4692:
4687:
4682:
4677:
4672:
4657:
4652:
4477:
4465:
4460:
4455:
4450:
4418:
4413:
4212:
4202:
4197:
4192:
4187:
4182:
4172:
4167:
4162:
4157:
4073:
4063:
4056:
4051:
4046:
4041:
4031:
3975:
3970:
3965:
3960:
3955:
3950:
3945:
3866:
3861:
3856:
3800:
3795:
3694:
3673:
3668:
3542:
3537:
3532:
3527:
3522:
3517:
2724:
2489:
2484:
2479:
2469:
2464:
2459:
2449:
2437:
2387:
2367:
2308:
2296:
2291:
2215:
2208:
2203:
2193:
2186:
2181:
2112:
2043:
2016:
2011:
1994:
1989:
1984:
1979:
1974:
1964:
1952:
1947:
1925:
1915:
1910:
1900:
515:
responses are much quicker than the intracellular receptors.
362:
358:
7174:
7169:
7164:
7154:
7142:
7137:
6984:
6967:
6831:
6826:
6821:
6792:
6787:
6720:
6715:
6710:
6705:
6700:
6695:
6690:
6685:
6636:
6530:
6492:
6467:
6462:
6457:
6440:
6332:
6325:
6320:
6201:
6196:
6191:
6186:
6181:
6176:
6171:
6166:
6156:
6149:
6139:
6134:
6122:
6112:
6107:
6090:
6085:
6080:
6063:
6058:
6053:
6028:
6023:
6018:
5736:
5731:
5726:
5721:
5716:
5655:
5630:
5625:
5566:
5561:
5556:
5551:
5546:
5541:
5536:
5531:
5526:
5497:
5492:
5385:
5380:
5375:
5370:
5356:
5351:
5346:
5341:
5336:
5307:
5302:
5297:
5263:
5258:
5253:
5248:
5243:
5238:
5203:
5191:
5186:
5181:
5134:
5129:
5124:
5119:
5114:
5035:
5020:
5010:
4986:
4981:
4967:
4962:
4957:
4947:
4942:
4930:
4925:
4869:
4864:
4642:
4627:
4622:
4610:
4605:
4438:
4433:
4428:
4272:
4207:
4152:
4147:
4142:
4026:
4021:
4016:
3940:
3935:
3930:
3925:
3920:
3915:
3910:
3905:
3900:
3883:
3878:
3822:
3817:
3785:
3780:
3775:
3765:
3760:
3753:
3748:
3743:
3738:
3728:
3723:
3706:
3564:
3559:
3554:
3482:
2943:
2938:
2933:
2928:
2923:
2918:
2831:
2816:
2793:
2766:
2739:
2734:
2699:
2677:
2672:
2667:
2650:
2645:
2635:
2625:
2575:
2533:
2528:
2511:
2506:
2501:
2399:
2394:
2382:
2340:
2335:
2325:
2240:
2235:
2225:
2144:
2127:
2090:
2078:
2073:
2048:
2006:
1935:
1930:
1905:
1888:
1883:
1878:
1873:
1868:
1858:
420:
687:
443:, ENaC sodium channels and ROMK potassium channels of the
6816:
6445:
6435:
6315:
5711:
5268:
4617:
4068:
3805:
3299:
2771:
2600:
2590:
2585:
2377:
2372:
1405:
772:
470:
138:
Steroid receptors of the nuclear receptor family are all
1456:
1000:
7668:
3017:
1652:
818:"The steroid and thyroid hormone receptor superfamily"
439:
has shown to increase the activity of the basolateral
875:"The nuclear receptor superfamily: the second decade"
7717:
7594:
1703:
1213:
1051:
1007:
The
Journal of Clinical Endocrinology and Metabolism
6946:
1624:"Female hormone could be key to male contraceptive"
1533:
7476:
1360:
7395:Acetylcholine metabolism and transport modulators
7246:
1264:
7757:
4517:
407:(steroid hormone), steroid receptors often form
38:(typically cytoplasmic or nuclear) and initiate
866:
924:Current Drug Targets. Inflammation and Allergy
518:
7650:
7312:Glutamate metabolism and transport modulators
7304:
7285:
7232:
7207:transcription factor/coregulator deficiencies
6278:β-Scaffold factors with minor groove contacts
1788:
1621:
54:subfamily 3 (NR3) that include receptors for
7625:Oxytocin and vasopressin receptor modulators
7534:
7400:Muscarinic acetylcholine receptor modulators
1697:
1646:
1570:
1399:
1354:
1258:
1207:
1142:
1093:
1091:
1045:
994:
921:
7405:Nicotinic acetylcholine receptor modulators
7296:
7277:
1527:
1499:
1493:
1450:
1315:
1148:
1104:International Journal of Molecular Sciences
950:
681:
637:
576:has been found to modulate the activity of
7327:Metabotropic glutamate receptor modulators
7239:
7225:
1795:
1781:
1764:. The University of Toledo. Archived from
1097:
809:
756:
1762:"MBC 3320 Steroid hormones and receptors"
1752:at the U.S. National Library of Medicine
1635:
1374:
1298:
1241:
1231:
1182:
1125:
1115:
1088:
1018:
915:
898:
849:
7538:
7322:Ionotropic glutamate receptor modulators
1149:Lee D, Kume M, Holy TE (December 2019).
411:. In the nucleus, the complex acts as a
7758:
7590:
7564:Xenobiotic-sensing receptor modulators
1759:
591:
373:
7730:Sodium-glucose transporter modulators
7504:Mineralocorticoid receptor modulators
7471:Lysophospholipid signaling modulators
7220:
6945:
6274:
4516:
3016:
1819:
1818:
1776:
1500:Wu FS, Gibbs TT, Farb DH (Sep 1991).
815:
7605:and gonadotropin receptor modulators
7529:Estrogen-related receptor modulators
7524:Aryl hydrocarbon receptor modulators
1706:Molecular and Cellular Endocrinology
349:-binding domain (LBD) can include a
167:Subfamily 3: Estrogen Receptor-like
127:
34:of target cells. They are generally
7430:Thyroid hormone receptor modulators
7299:metabolism and transport modulators
2961:(1.6) Basic helix-span-helix (bHSH)
13:
7499:Glucocorticoid receptor modulators
14:
7777:
7745:Nitric oxide signaling modulators
7663:Growth factor receptor modulators
1743:
213:Group C: 3-Ketosteroid receptors
7610:Melanocortin receptor modulators
7509:Progesterone receptor modulators
7456:Leukotriene signaling modulators
1385:10.1016/j.pharmthera.2007.03.007
7671:receptor superfamily modulators
7653:receptor superfamily modulators
7645:Interleukin receptor modulators
7585:Angiotensin receptor modulators
7461:Prostanoid signaling modulators
7451:Cannabinoid receptor modulators
7415:Imidazoline receptor modulators
7357:Monoamine metabolism modulators
6948:(0) Other transcription factors
6232:transcriptional enhancer factor
1849:Activating transcription factor
1622:Ewen Callaway (16 March 2011).
1363:Pharmacology & Therapeutics
1035:
546:
233:2: Mineralocorticoid receptor (
7697:Histone deacetylase inhibitors
7615:Neurokinin receptor modulators
7337:Adrenergic receptor modulators
1098:Wang C, Liu Y, Cao JM (2014).
1054:Nature Reviews. Drug Discovery
972:10.1016/j.steroids.2004.05.013
747:
738:
543:, specifically the V1 family.
430:
70:for certain steroid hormones.
1:
7640:Chemokine receptor modulators
7559:Vitamin D receptor modulators
7514:Steroid metabolism modulators
7377:Serotonin receptor modulators
7372:Monoamine reuptake inhibitors
7352:Melatonin receptor modulators
7347:Histamine receptor modulators
6162:Interferon regulatory factors
4401:(2.5) Alternating composition
3597:General transcription factors
1548:10.1016/S0166-4328(97)86061-5
631:
7702:Phosphodiesterase inhibitors
7635:Cytokine receptor modulators
7554:Retinoid receptor modulators
7494:Estrogen receptor modulators
7489:Androgen receptor modulators
7342:Dopamine receptor modulators
7291:receptor positive modulators
5447:Octamer transcription factor
2155:(1.2) Basic helix-loop-helix
1471:10.1016/0896-6273(90)90202-Q
891:10.1016/0092-8674(95)90199-X
787:10.1016/0092-8674(93)90390-C
597:Sex hormone-binding globulin
415:, augmenting or suppressing
357:(namely heat shock proteins
299:
216:1: Glucocorticoid receptor (
7:
7317:Glycine receptor modulators
2221:Myogenic regulatory factors
614:
580:(cation channels of sperm)
519:G protein-coupled receptors
351:nuclear localization signal
345:: The moderately conserved
152:nuclear localization signal
122:Mineralocorticoid Receptors
60:G protein-coupled receptors
10:
7782:
7692:Cytochrome P450 modulators
7620:Opioid receptor modulators
7420:Purine receptor modulators
7367:Monoamine releasing agents
1760:Messer WS (3 April 2000).
1536:Behavioural Brain Research
427:as with type I receptors.
378:
250:3: Progesterone receptor (
131:
7679:
7597:axis signaling modulators
7572:
7438:
7425:Sigma receptor modulators
7261:
7202:
7064:
7024:
6993:
6958:
6954:
6941:
6883:
6860:
6842:
6592:
6566:
6518:
6421:
6368:
6288:
6284:
6270:
6222:
6041:(3.5) Tryptophan clusters
6039:
5999:
5695:
5512:
5152:
4878:
4566:
4547:
4535:
4531:
4512:
4486:
4399:
4378:
3580:
3500:
3471:
3451:
3426:
3389:
3308:
3204:
3052:
3033:
3029:
3012:
2959:
2904:
2802:
2712:
2688:
2611:
2544:
2408:
2358:
2167:
2153:
1831:
1827:
1814:
1718:10.1016/j.mce.2009.08.009
621:Membrane steroid receptor
20:Steroid hormone receptors
16:Group of protein families
7521:Other nuclear receptors:
7274:Amino acids and related:
6862:(4.10) Cold-shock domain
1754:Medical Subject Headings
936:10.2174/1568010042634541
476:
453:cortical collecting duct
331:hormone response element
198:2: Estrogen receptor-β (
185:1: Estrogen receptor-α (
115:Glucocorticoid Receptors
84:
7766:Intracellular receptors
1808:intracellular receptors
1340:10.1126/science.2422758
1175:10.1126/science.aax8055
842:10.1126/science.3283939
697:Pharmacological Reviews
647:Pharmacological Reviews
36:intracellular receptors
7712:Ion channel modulators
1509:Molecular Pharmacology
1291:10.1126/sciadv.aaz6868
1020:10.1210/jc.2003-031681
535:Sulfated steroids and
423:by its action on DNA.
343:Hormone binding domain
271:4: Androgen receptor (
101:Progesterone Receptors
68:cell surface receptors
7362:Monoamine neurotoxins
6571:TATA-binding proteins
1804:Transcription factors
1637:10.1038/news.2011.163
1117:10.3390/ijms150915412
816:Evans RM (May 1988).
603:and synthesis of the
541:vomeronasal receptors
539:are also detected by
403:After binding to the
140:transcription factors
7735:Symporter inhibitors
552:Neuroactive steroids
501:Chromatin Remodeling
437:aldosterone receptor
413:transcription factor
7479:receptor modulators
7307:receptor modulators
7280:receptor modulators
7066:(0.6) Miscellaneous
6597:High-mobility group
6293:Rel homology region
3283:Testicular receptor
3024:DNA-binding domains
1675:10.1038/nature09767
1667:2011Natur.471..387L
1599:10.1038/nature09769
1591:2011Natur.471..382S
1428:10.1038/nature05324
1420:2006Natur.444..486H
1283:2020SciA....6.6868W
1233:10.7554/eLife.03025
1167:2019Sci...366.1384L
1161:(6471): 1384–1389.
834:1988Sci...240..889E
592:SHBG/SHBG-R complex
374:Mechanism of action
156:heat shock proteins
50:are members of the
40:signal transduction
7720:channel modulators
6431:p53 p63 p73 family
6004:Heat shock factors
435:The cell membrane
386:heat shock protein
315:DNA binding domain
108:Androgen Receptors
94:Estrogen Receptors
30:, and also on the
7753:
7752:
7574:Peptides/proteins
7214:
7213:
7198:
7197:
7194:
7193:
6937:
6936:
6933:
6932:
6266:
6265:
6262:
6261:
5508:
5507:
5148:
5147:
4508:
4507:
4504:
4503:
3496:
3495:
3352:Mineralocorticoid
3008:
3007:
3004:
3003:
2708:
2707:
1821:(1) Basic domains
1768:on 17 April 2008.
1750:Steroid+Receptors
709:10.1124/pr.58.4.9
659:10.1124/pr.58.4.8
172:Estrogen receptor
163:Nuclear receptors
128:Nuclear receptors
22:are found in the
7773:
7719:
7670:
7652:
7604:
7596:
7592:
7548:
7540:
7536:
7478:
7384:
7306:
7298:
7290:
7279:
7241:
7234:
7227:
7218:
7217:
7038:-related factors
6956:
6955:
6943:
6942:
6844:(4.9) Grainyhead
6286:
6285:
6272:
6271:
6224:(3.6) TEA domain
5514:(3.2) Paired box
5155:
4889:
4883:
4577:
4571:
4564:
4563:
4560:
4554:
4545:
4544:
4533:
4532:
4522:Helix-turn-helix
4514:
4513:
3476:
3456:
3431:
3394:
3364:Estrogen related
3313:
3209:
3057:
3050:
3049:
3038:Nuclear receptor
3031:
3030:
3014:
3013:
2693:
2614:
2547:
2416:
2361:
2170:
2165:
2164:
1829:
1828:
1816:
1815:
1797:
1790:
1783:
1774:
1773:
1769:
1738:
1737:
1701:
1695:
1694:
1661:(7338): 387–91.
1650:
1644:
1641:
1639:
1618:
1574:
1568:
1567:
1531:
1525:
1524:
1506:
1497:
1491:
1490:
1454:
1448:
1447:
1403:
1397:
1396:
1378:
1358:
1352:
1351:
1334:(4753): 1004–7.
1319:
1313:
1312:
1302:
1277:(22): eaaz6868.
1262:
1256:
1255:
1245:
1235:
1211:
1205:
1204:
1186:
1146:
1140:
1139:
1129:
1119:
1095:
1086:
1085:
1049:
1043:
1039:
1033:
1032:
1022:
998:
992:
991:
954:
948:
947:
919:
913:
912:
902:
870:
864:
863:
853:
828:(4854): 889–95.
813:
807:
806:
770:
760:
754:
751:
745:
742:
736:
735:
733:
727:. Archived from
694:
685:
679:
678:
641:
626:Nuclear receptor
601:adenylyl cyclase
530:adenylyl cyclase
146:and move to the
134:nuclear receptor
52:nuclear receptor
44:steroid hormones
7781:
7780:
7776:
7775:
7774:
7772:
7771:
7770:
7756:
7755:
7754:
7749:
7681:
7675:
7660:Growth factors:
7568:
7434:
7289:
7267:similar/related
7266:
7257:
7245:
7215:
7210:
7190:
7060:
7020:
6989:
6950:
6929:
6879:
6856:
6838:
6588:
6562:
6514:
6417:
6364:
6280:
6258:
6218:
6035:
5995:
5691:
5504:
5153:
5144:
4885:
4884:
4879:
4874:
4573:
4572:
4567:
4556:
4555:
4548:
4527:
4500:
4482:
4395:
4383:
4374:
3589:
3585:
3576:
3505:
3502:(2.2) Other Cys
3492:
3472:
3467:
3452:
3447:
3427:
3422:
3390:
3385:
3320:Steroid hormone
3309:
3304:
3205:
3200:
3064:Thyroid hormone
3053:
3044:
3025:
3000:
2955:
2900:
2798:
2704:
2691:
2689:
2684:
2612:
2607:
2545:
2540:
2411:
2409:
2404:
2359:
2354:
2168:
2149:
1823:
1810:
1801:
1746:
1741:
1702:
1698:
1651:
1647:
1585:(7338): 382–6.
1575:
1571:
1542:(1–2): 159–64.
1532:
1528:
1504:
1498:
1494:
1455:
1451:
1414:(7118): 486–9.
1404:
1400:
1359:
1355:
1320:
1316:
1263:
1259:
1212:
1208:
1147:
1143:
1110:(9): 15412–25.
1096:
1089:
1066:10.1038/nrd1283
1050:
1046:
1040:
1036:
999:
995:
955:
951:
920:
916:
871:
867:
814:
810:
762:
761:
757:
752:
748:
743:
739:
731:
692:
686:
682:
642:
638:
634:
617:
594:
567:sigma receptors
559:
549:
521:
494:gene expression
486:Gene Regulation
479:
433:
381:
376:
309:Variable domain
302:
136:
130:
87:
32:plasma membrane
17:
12:
11:
5:
7779:
7769:
7768:
7751:
7750:
7748:
7747:
7738:
7737:
7732:
7723:
7722:
7714:
7705:
7704:
7699:
7694:
7685:
7683:
7677:
7676:
7674:
7673:
7665:
7656:
7655:
7647:
7642:
7637:
7628:
7627:
7622:
7617:
7612:
7607:
7599:
7587:
7578:
7576:
7570:
7569:
7567:
7566:
7561:
7556:
7551:
7543:
7531:
7526:
7517:
7516:
7511:
7506:
7501:
7496:
7491:
7482:
7481:
7473:
7468:Phospholipids:
7464:
7463:
7458:
7453:
7444:
7442:
7436:
7435:
7433:
7432:
7427:
7422:
7417:
7408:
7407:
7402:
7397:
7392:Acetylcholine:
7388:
7387:
7379:
7374:
7369:
7364:
7359:
7354:
7349:
7344:
7339:
7330:
7329:
7324:
7319:
7314:
7309:
7301:
7293:
7287:
7282:
7270:
7268:
7259:
7258:
7244:
7243:
7236:
7229:
7221:
7212:
7211:
7203:
7200:
7199:
7196:
7195:
7192:
7191:
7189:
7188:
7179:
7178:
7177:
7172:
7167:
7157:
7152:
7151:
7150:
7145:
7140:
7130:
7129:
7128:
7123:
7113:
7108:
7107:
7106:
7101:
7096:
7091:
7086:
7081:
7070:
7068:
7062:
7061:
7059:
7058:
7053:
7048:
7042:
7040:
7022:
7021:
7019:
7018:
7013:
7008:
7002:
7000:
6991:
6990:
6988:
6987:
6982:
6981:
6980:
6975:
6964:
6962:
6952:
6951:
6939:
6938:
6935:
6934:
6931:
6930:
6928:
6927:
6926:
6925:
6920:
6915:
6910:
6905:
6900:
6889:
6887:
6881:
6880:
6878:
6877:
6872:
6866:
6864:
6858:
6857:
6855:
6854:
6848:
6846:
6840:
6839:
6837:
6836:
6835:
6834:
6829:
6824:
6819:
6809:
6808:
6807:
6802:
6801:
6800:
6795:
6790:
6775:
6770:
6765:
6764:
6763:
6758:
6753:
6748:
6743:
6738:
6733:
6728:
6723:
6718:
6713:
6708:
6703:
6698:
6693:
6688:
6678:
6677:
6676:
6671:
6661:
6660:
6659:
6654:
6649:
6644:
6634:
6633:
6632:
6627:
6622:
6617:
6607:
6601:
6599:
6590:
6589:
6587:
6586:
6581:
6575:
6573:
6564:
6563:
6561:
6560:
6555:
6554:
6553:
6548:
6543:
6538:
6527:
6525:
6516:
6515:
6513:
6512:
6507:
6506:
6505:
6500:
6495:
6490:
6485:
6480:
6475:
6470:
6465:
6460:
6450:
6449:
6448:
6443:
6438:
6427:
6425:
6423:(4.3) p53-like
6419:
6418:
6416:
6415:
6414:
6413:
6408:
6403:
6398:
6393:
6388:
6377:
6375:
6366:
6365:
6363:
6362:
6361:
6360:
6355:
6350:
6345:
6340:
6330:
6329:
6328:
6323:
6318:
6313:
6308:
6297:
6295:
6282:
6281:
6268:
6267:
6264:
6263:
6260:
6259:
6257:
6256:
6255:
6254:
6249:
6244:
6239:
6228:
6226:
6220:
6219:
6217:
6216:
6211:
6206:
6205:
6204:
6199:
6194:
6189:
6184:
6179:
6174:
6169:
6159:
6154:
6153:
6152:
6147:
6142:
6137:
6127:
6126:
6125:
6120:
6115:
6110:
6100:
6095:
6094:
6093:
6088:
6083:
6073:
6068:
6067:
6066:
6061:
6056:
6045:
6043:
6037:
6036:
6034:
6033:
6032:
6031:
6026:
6021:
6008:
6006:
5997:
5996:
5994:
5993:
5992:
5991:
5986:
5981:
5976:
5971:
5966:
5961:
5956:
5951:
5946:
5941:
5936:
5931:
5926:
5921:
5916:
5911:
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1836:leucine zipper
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1744:External links
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1013:(3): 1443–51.
993:
966:(8–9): 553–9.
949:
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755:
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734:on 2019-02-28.
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1779:
1778:
1775:
1767:
1763:
1758:
1755:
1751:
1748:
1747:
1735:
1731:
1727:
1723:
1719:
1715:
1711:
1707:
1700:
1692:
1688:
1684:
1680:
1676:
1672:
1668:
1664:
1660:
1656:
1649:
1638:
1633:
1629:
1625:
1620:
1619:
1616:
1612:
1608:
1604:
1600:
1596:
1592:
1588:
1584:
1580:
1573:
1565:
1561:
1557:
1553:
1549:
1545:
1541:
1537:
1530:
1522:
1518:
1514:
1510:
1503:
1496:
1488:
1484:
1480:
1476:
1472:
1468:
1465:(5): 759–65.
1464:
1460:
1453:
1445:
1441:
1437:
1433:
1429:
1425:
1421:
1417:
1413:
1409:
1402:
1394:
1390:
1386:
1382:
1377:
1372:
1368:
1364:
1357:
1349:
1345:
1341:
1337:
1333:
1329:
1325:
1318:
1310:
1306:
1301:
1296:
1292:
1288:
1284:
1280:
1276:
1272:
1268:
1261:
1253:
1249:
1244:
1239:
1234:
1229:
1225:
1221:
1217:
1210:
1202:
1198:
1194:
1190:
1185:
1180:
1176:
1172:
1168:
1164:
1160:
1156:
1152:
1145:
1137:
1133:
1128:
1123:
1118:
1113:
1109:
1105:
1101:
1094:
1092:
1083:
1079:
1075:
1071:
1067:
1063:
1059:
1055:
1048:
1038:
1030:
1026:
1021:
1016:
1012:
1008:
1004:
997:
989:
985:
981:
977:
973:
969:
965:
961:
953:
945:
941:
937:
933:
930:(4): 335–46.
929:
925:
918:
910:
906:
901:
896:
892:
888:
884:
880:
876:
869:
861:
857:
852:
847:
843:
839:
835:
831:
827:
823:
819:
812:
804:
800:
796:
792:
788:
784:
781:(3): 567–78.
780:
776:
769:
765:
759:
750:
741:
730:
726:
722:
718:
714:
710:
706:
703:(4): 782–97.
702:
698:
691:
684:
676:
672:
668:
664:
660:
656:
653:(4): 773–81.
652:
648:
640:
636:
627:
624:
622:
619:
618:
612:
610:
609:transmembrane
606:
602:
598:
589:
587:
583:
582:voltage-gated
579:
575:
570:
568:
564:
560:
553:
544:
542:
538:
533:
531:
525:
516:
512:
508:
504:
502:
497:
495:
489:
487:
482:
474:
472:
468:
463:
460:
458:
454:
450:
449:distal tubule
446:
442:
438:
428:
424:
422:
418:
417:transcription
414:
410:
406:
401:
397:
395:
391:
387:
368:
364:
360:
356:
352:
348:
344:
341:
338:
335:
332:
328:
324:
320:
316:
313:
310:
307:
306:
305:
288:
284:
280:
279:
274:
270:
267:
263:
259:
258:
253:
249:
246:
242:
241:
236:
232:
229:
225:
224:
219:
215:
214:
212:
207:
206:
201:
197:
194:
193:
188:
184:
183:
181:
177:
173:
169:
168:
166:
165:
164:
161:
160:
159:
157:
153:
149:
145:
141:
135:
125:
123:
118:
116:
111:
109:
104:
102:
97:
95:
90:
82:
80:
76:
71:
69:
65:
61:
57:
53:
49:
45:
41:
37:
33:
29:
25:
21:
7741:
7726:
7708:
7688:
7682:non-receptor
7659:
7631:
7581:
7520:
7485:
7467:
7448:Eicosanoids:
7447:
7411:
7391:
7333:
7273:
7204:
7159:
7115:
7073:
7065:
7037:
7031:
7025:
6994:
6959:
6947:
6884:
6861:
6843:
6811:
6782:
6663:
6593:
6567:
6519:
6422:
6369:
6289:
6277:
6231:
6223:
6129:
6075:
6048:
6040:
6011:
6000:
5744:FOX proteins
5704:winged helix
5696:
5667:
5650:
5593:
5513:
5487:
5365:
5331:
5314:
5292:
5275:
5208:
5176:
5030:
4993:
4974:
4920:
4886:
4880:
4574:
4568:
4557:
4551:Antennapedia
4549:
4536:
4524:
4518:
4487:
4445:
4423:
4400:
4379:
4137:
4090:
4036:
3982:
3895:
3873:
3851:
3829:
3812:
3770:
3699:
3581:
3549:
3501:
3473:
3453:
3428:
3391:
3357:Progesterone
3319:
3310:
3206:
3054:
3040:
3034:
3018:
2960:
2913:
2905:
2803:
2713:
2662:
2620:
2580:
2553:
2523:
2496:
2330:
2320:
2303:
2286:
2198:
2154:
2122:
2085:
1942:
1832:
1820:
1766:the original
1712:(1): 79–85.
1709:
1705:
1699:
1658:
1654:
1648:
1627:
1582:
1578:
1572:
1539:
1535:
1529:
1515:(3): 333–6.
1512:
1508:
1495:
1462:
1458:
1452:
1411:
1407:
1401:
1369:(1): 20–34.
1366:
1362:
1356:
1331:
1327:
1317:
1274:
1270:
1260:
1223:
1219:
1209:
1158:
1154:
1144:
1107:
1103:
1060:(1): 27–41.
1057:
1053:
1047:
1037:
1010:
1006:
996:
963:
959:
952:
927:
923:
917:
885:(6): 835–9.
882:
878:
868:
825:
821:
811:
778:
774:
758:
749:
740:
729:the original
700:
696:
683:
650:
646:
639:
595:
574:progesterone
572:The steroid
571:
550:
547:Ion channels
534:
526:
522:
513:
509:
505:
498:
490:
483:
480:
464:
461:
434:
425:
402:
398:
382:
367:conformation
342:
337:Hinge region
336:
327:zinc fingers
314:
308:
303:
287:Testosterone
283:Sex hormones
276:
266:Progesterone
262:Sex hormones
255:
238:
221:
203:
190:
176:Sex hormones
148:cell nucleus
137:
119:
112:
105:
98:
91:
88:
79:testosterone
75:progesterone
72:
64:ion channels
19:
18:
7334:Monoamines:
7263:Amino acids
6885:(4.11) Runt
4540:Homeodomain
4138:zinc finger
3474:subfamily 0
3454:subfamily 6
3429:subfamily 5
3392:subfamily 4
3311:subfamily 3
3207:subfamily 2
3055:subfamily 1
3022:Zinc finger
2265:Neurogenins
1833:(1.1) Basic
441:Na/K ATPase
431:Non-genomic
419:particular
394:heterodimer
245:Aldosterone
7680:Others and
7632:Cytokines:
7549:modulators
7541:modulators
7385:modulators
7255:modulators
5418:POU domain
4558:ANTP class
4488:(2.6) WRKY
3771:GLI family
2906:(1.5) RF-X
2804:(1.4) NF-1
1505:(abstract)
1376:1607.02870
1226:: e03025.
632:References
586:chemotaxis
537:bile acids
471:Akt kinase
355:chaperones
7582:Peptides:
7486:Steroids:
7252:signaling
7205:see also
7046:Apetala 2
5700:Fork head
4380:(2.4) Cys
3582:(2.3) Cys
2314:Scleraxis
1201:209339279
771:;
390:homodimer
323:histidine
300:Structure
275:; NR3C4,
254:; NR3C3,
202:; NR3A2,
189:; NR3A1,
170:Group A:
48:receptors
7760:Category
7689:Enzymes:
7248:Receptor
6523:MADS box
4663:Homeobox
4575:Hox-like
4569:protoHOX
3330:Estrogen
3325:Androgen
3179:Rev-ErbA
2717:bHLH-ZIP
2692:bHLH-COE
2231:Myogenin
1734:27912941
1726:19698759
1683:21412339
1607:21412338
1487:12626366
1436:17108970
1393:17531325
1309:32523992
1252:25073926
1193:31831669
1136:25257522
1082:17487277
1074:14708019
1042:8521507.
1029:15001646
988:25453428
980:15288769
960:Steroids
944:15584884
803:20795587
725:28626145
717:17132855
675:45996586
667:17132854
615:See also
457:nephrons
319:cysteine
228:Cortisol
180:Estrogen
56:estrogen
7742:Others:
7412:Others:
6923:RUNX1T1
6903:CBFA2T3
6898:CBFA2T2
6778:TCF/LEF
4887:NK-like
4881:metaHOX
4584:ParaHox
4525:domains
3216:COUP-TF
2690:Group F
2613:Group E
2546:Group D
2410:Group C
2360:Group B
2304:Paraxis
2169:Group A
1691:4340309
1663:Bibcode
1615:4431334
1587:Bibcode
1564:3979800
1556:9062676
1521:1654510
1479:2160838
1444:4382394
1416:Bibcode
1348:2422758
1328:Science
1300:7259934
1279:Bibcode
1271:Sci Adv
1243:4107909
1184:7591936
1163:Bibcode
1155:Science
1127:4200746
909:8521507
900:6159888
860:3283939
851:6159881
830:Bibcode
822:Science
795:8221895
578:CatSper
447:in the
379:Genomic
321:and no
144:cytosol
66:act as
28:cytosol
24:nucleus
7440:Lipids
5636:Bicoid
4901:BARHL2
4896:BARHL1
4478:JMJD1B
4391:HIVEP1
2876:I-SMAD
2844:R-SMAD
2762:MLXIPL
2517:Period
2443:ARNTL2
2248:NeuroD
1756:(MeSH)
1732:
1724:
1689:
1681:
1655:Nature
1628:Nature
1613:
1605:
1579:Nature
1562:
1554:
1519:
1485:
1477:
1459:Neuron
1442:
1434:
1408:Nature
1391:
1346:
1307:
1297:
1250:
1240:
1199:
1191:
1181:
1134:
1124:
1080:
1072:
1027:
986:
978:
942:
907:
897:
858:
848:
801:
793:
723:
715:
673:
665:
565:, and
409:dimers
405:ligand
347:ligand
333:(HRE).
77:, and
7595:IGF-1
7383:hTAAR
7186:Sigma
7051:EREBP
7035:EREBP
7026:(0.5)
6995:(0.3)
6918:RUNX3
6913:RUNX2
6908:RUNX1
6852:TFCP2
6773:SSRP1
6594:(4.7)
6584:TBPL1
6568:(4.6)
6520:(4.4)
6370:(4.2)
6311:NFKB2
6306:NFKB1
6301:NF-κB
6290:(4.1)
6214:MYBL2
6001:(3.4)
5697:(3.3)
5646:BICD2
5621:SHOX2
5589:PROP1
5573:PRRX
5483:SATB2
5428:BRN-3
5423:PIT-1
5315:PKNOX
5230:TALE
5226:NOBOX
5199:HESX1
5172:CUTL1
5154:other
5048:NANOG
4911:BARX2
4906:BARX1
4658:MEOX2
4653:MEOX1
4537:(3.1)
4446:JARID
4419:GRLF1
4414:DIDO1
4074:Zbtb7
4064:TSHZ3
4032:PRDM9
3830:HIVEP
3695:ATBF1
3649:TFIIH
3634:TFIIF
3617:TFIIE
3612:TFIID
3607:TFIIB
3602:TFIIA
3572:TRPS1
3438:LRH-1
3416:NURR1
3406:NGFIB
3234:Ear-2
3035:(2.1)
2777:SREBP
2714:(1.3)
2476:NPAS
2465:EPAS1
2450:CLOCK
2438:ARNTL
2412:bHLH-
2388:n-Myc
2383:l-Myc
2378:c-Myc
2368:FIGLA
2350:Twist
2309:TCF15
2216:MESP2
2194:ATOH1
2187:ASCL2
2182:ASCL1
2113:NFIL3
2044:GABPA
2039:DDIT3
1970:C/EBP
1965:BLZF1
1926:c-Jun
1916:FOSL2
1911:FOSL1
1901:c-Fos
1730:S2CID
1687:S2CID
1611:S2CID
1560:S2CID
1483:S2CID
1440:S2CID
1371:arXiv
1220:eLife
1197:S2CID
1078:S2CID
984:S2CID
799:S2CID
732:(PDF)
721:S2CID
693:(PDF)
671:S2CID
477:Other
421:genes
363:hsp56
359:hsp90
240:NR3C2
223:NR3C1
85:Types
7669:TGFβ
7603:GnRH
7547:PPAR
7537:and
7297:GABA
7286:GABA
7278:GABA
7155:MNDA
7074:ARID
7029:AP-2
7016:RBL2
7011:RBL1
6985:HBP1
6968:HMGA
6875:YBX1
6870:CSDA
6805:LEF1
6637:HMGN
6610:HMGB
6531:Mef2
6510:MYRF
6498:TBR2
6493:TBR1
6441:TP63
6381:STAT
6373:STAT
6333:NFAT
6326:RELB
6321:RELA
6276:(4)
6157:FLI1
6123:SPIB
5824:D4L6
5819:D4L5
5814:D4L4
5809:D4L3
5804:D4L1
5668:PITX
5631:VSX2
5626:VSX1
5616:SHOX
5594:PHOX
5276:MEIS
5204:HOPX
5140:VAX2
5135:VAX1
5130:TLX3
5125:TLX2
5120:TLX1
5115:NATO
5098:HMX3
5093:HMX2
5088:HMX1
5026:LBX2
5021:LBX1
5011:HHEX
4870:MNX1
4865:GBX2
4860:GBX1
4648:Evx2
4643:Evx1
4611:PDX1
4606:Xlox
4496:WRKY
4409:AIRE
4368:804A
4091:ZBTB
4037:SALL
4027:OSR1
4022:MYT1
4017:MTF1
3852:IKZF
3791:REST
3766:GFI1
3761:ERV3
3729:E4F1
3724:CTCF
3513:GATA
3483:DAX1
3463:GCNF
3411:NOR1
3239:HNF4
3108:PPAR
3041:(Cys
2969:AP-2
2839:SMAD
2794:USF1
2767:MXI1
2747:MITF
2740:MXD3
2735:MXD1
2725:AP-4
2700:EBF1
2576:Pho4
2554:BHLH
2433:ARNT
2428:AHRR
2400:TCF4
2395:MXD4
2326:LYL1
2287:OLIG
2241:MYF6
2236:MYF5
2226:MyoD
2199:HAND
2177:AS-C
2159:bHLH
2145:XBP1
2049:GCN4
2029:CREM
2007:CREB
1960:BATF
1943:BACH
1936:JunD
1931:JUNB
1921:JDP2
1906:FOSB
1896:AP-1
1854:AATF
1840:bZIP
1806:and
1722:PMID
1679:PMID
1603:PMID
1552:PMID
1517:PMID
1475:PMID
1432:PMID
1389:PMID
1344:PMID
1305:PMID
1248:PMID
1189:PMID
1132:PMID
1070:PMID
1025:PMID
976:PMID
940:PMID
905:PMID
879:Cell
856:PMID
791:PMID
775:Cell
768:1HCQ
713:PMID
663:PMID
605:cAMP
563:NMDA
556:GABA
469:and
467:PI3k
451:and
361:and
205:ESR2
192:ESR1
62:and
42:for
7718:TRP
7651:TNF
7539:LXR
7535:FXR
7477:PAF
7305:GHB
7265:and
7182:Rho
7160:NFY
7133:MLL
7116:IFI
7111:CAP
6893:CBF
6812:TOX
6783:TCF
6768:SRY
6681:SOX
6664:HNF
6605:BBX
6579:TBP
6558:SRF
6503:TFT
6453:TBX
6446:p73
6436:p53
6316:REL
6209:MYB
6130:ETV
6118:ERG
6103:ETS
6098:ERF
6076:ELK
6071:EGF
6049:ELF
6013:HSF
5712:E2F
5651:OTX
5641:GSC
5611:RAX
5522:PAX
5488:ZEB
5461:3/4
5411:21A
5366:PHF
5332:SIX
5293:PBX
5269:MKX
5234:IRX
5209:LMX
5177:FHL
5167:CRX
5162:ARX
5108:6-2
5103:6-1
5083:3-2
5078:3-1
5073:2-5
5068:2-3
5063:2-2
5058:2-1
5053:NKX
5031:MSX
5016:HLX
4976:EMX
4938:DLX
4921:DBX
4916:BSX
4853:D13
4848:D12
4843:D11
4838:D10
4808:C13
4803:C12
4798:C11
4793:C10
4763:B13
4713:A13
4708:A11
4703:A10
4618:Cdx
4589:Gsx
4519:(3)
4424:ING
4363:655
4358:649
4353:644
4348:638
4343:593
4338:471
4333:452
4328:451
4323:423
4318:384
4313:366
4308:365
4303:350
4298:346
4293:330
4288:318
4283:300
4278:281
4273:268
4268:267
4263:259
4258:239
4253:238
4248:219
4243:217
4238:202
4233:165
4228:148
4223:146
4218:143
4178:33B
4069:WT1
3896:KLF
3874:ILF
3813:HIC
3806:YY1
3734:EGR
3717:11B
3712:11A
3701:BCL
3684:3C2
3679:3C1
3586:His
3550:MTA
3488:SHP
3443:SF1
3401:NUR
3300:TLX
3261:RXR
3256:PNR
3196:VDR
3157:ROR
3135:RAR
3130:PXR
3118:β/δ
3091:LXR
3086:FXR
3081:CAR
3019:(2)
2949:ANK
2914:RFX
2812:NFI
2772:Myc
2757:MLX
2752:MNT
2730:MAX
2663:HEY
2621:HES
2524:SIM
2497:PER
2455:HIF
2423:AhR
2414:PAS
2373:Myc
2331:TAL
2321:SLC
2123:NRF
2118:NRL
2086:NFE
2059:MAF
2054:HLF
2034:DBP
1714:doi
1710:316
1671:doi
1659:471
1632:doi
1595:doi
1583:471
1544:doi
1467:doi
1424:doi
1412:444
1381:doi
1367:116
1336:doi
1332:232
1295:PMC
1287:doi
1238:PMC
1228:doi
1179:PMC
1171:doi
1159:366
1122:PMC
1112:doi
1062:doi
1015:doi
968:doi
932:doi
895:PMC
887:doi
846:PMC
838:doi
826:240
783:doi
764:PDB
705:doi
655:doi
588:).
499:3.
484:1.
455:of
392:or
281:) (
260:) (
257:PGR
243:) (
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