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1307:...41% of the studies did not describe the age of their animal model... A general observation in our risk of bias assessment was that the majority of the included studies did not provide sufficient information to assess the risk of bias. The studies did not adequately describe details regarding allocation of animals to the experimental groups, adjustments for baseline differences, concealment of allocation, randomization, blinding and addressing incomplete outcome data.
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comparable to human diseases' but the paper cited for this claim actually states: 'Much animal research into potential treatments for humans is wasted because it is poorly conducted and not evaluated through systematic reviews'). Every SR and MS I could find is critical of animal testing, so the proposed article is titled '
1178:'. I believe this would contribute to a more informed and robust account of animal testing. If there are objections based on the negative accounts of the SR's and MS's, then if anyone can supply links to publicly verifiable material that is supportive, then those can be included too (I could not find any).
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accurately (hence just listing quotes to avoid accusations of bias). Again, if there are MS's and SR's out there that are supportive, then I would love to know about them. Otherwise, it would also be helpful to accurately reflect the papers that are referenced, such as the one I already mentioned, above.
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Systematic review and meta-analysis have provided empirical evidence that too many preclinical experiments lack methodological rigor, and this leads to inflated treatment effects. There is of course no guarantee that improvements in the validity of preclinical animal studies and reduced publication
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The unreliability of animal experimentation across a wide range of areas undermines scientific arguments in favor of the practice… animal experimentation often significantly harms humans through misleading safety studies, potential abandonment of effective therapeutics, and direction of resources
1173:
I'd like to supplement this article with a list of
Systematic Reviews (SR's) and Meta-Studies (MS's). Unfortunately the few that are mentioned do not seem to be accurately represented (e.g. this article states: 'such studies can be difficult to interpret, and it is argued that they are not always
1321:
These deficiencies in the reporting of animal study design, which are clearly widespread, raise the concern that the reviewers of these studies could not adequately identify potential limitations in the experimental design and/or data analysis, limiting the benefit of the findings...Numerous
1215:
The problem is "best" studies according to whom? That could result in accusations of cherry picking and synthesising and such. All SR's and MS's I have found are very critical of animal testing, so I simply believe it would make for a more rounded and robust article to acknowledge them, and
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publications have called attention to the lack of transparency in reporting, yet studies in the life sciences in general, and in animals in particular, still often lack adequate reporting on the design, conduct and analysis of the experiments.
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Systemic reviews have pointed out that animal testing often fails to accurately mirror outcomes in humans. For instance, a 2013 review noted that some 100 vaccines have been shown to prevent HIV in animals, yet none of them have worked on
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Systematic reviews are generally regarded by professionals in the field of evidence-based medicine as the highest level of medical evidence…However, they are not yet widely used nor undertaken in the field of animal
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1196:, Can you link 3-5 of the best studies, and the conclusion you'd like to draw from them? As I understand it, you'd like to note that animal testing is flawed as a research practice?
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A gold standard publication checklist to improve the quality of animal studies, to fully integrate the Three Rs, and to make systematic reviews more feasible (2010)
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away from more effective testing methods… of every 5,000–10,000 potential drugs investigated , only about 5 proceed to Phase 1 clinical trials .
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Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically (2014)
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A call for transparent reporting to optimize the predictive value of preclinical research (2012)
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I think I see where you are going. OK, I believe the "best" (general) articles are:
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bias will improve the translational hit of interventions from bench to bedside.
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when adding content and consider tagging or removing unsourced information.
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511845
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690347
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013765
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594046
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