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559:. As Director of the Molecular Diagnostic lab at Cincinnati Children's Hospital Medical Center, Huang is currently interested in identifying disease-causing genes and their molecular mechanisms. His group has identified many novel genes that are linked with human diseases, and has used
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Abrams, Alexander J.; Hufnagel, Robert B.; Rebelo, Adriana; Zanna, Claudia; Patel, Neville; Gonzalez, Michael A.; Campeanu, Ion J.; Griffin, Laurie B.; Groenewald, Saskia (August 2015).
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Huang’s group has identified and published seven novel genes in the past 5 years that are associated with human diseases. The relevant genes and their associated disorders include
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Kang, Eunju; Wang, Xinjian; Tippner-Hedges, Rebecca; Ma, Hong; Folmes, Clifford D. L.; Gutierrez, Nuria Marti; Lee, Yeonmi; Van Dyken, Crystal; Ahmed, Riffat (May 5, 2016).
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Simon, Mariella; Richard, Elodie M.; Wang, Xinjian; Shahzad, Mohsin; Huang, Vincent H.; Qaiser, Tanveer A.; Potluri, Prasanth; Mahl, Sarah E.; Davila, Antonio (March 2015).
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Abbott, Alison; Butler, Declan; Castelvecchi, Davide; Cressey, Daniel; Gibney, Elizabeth; Ledford, Heidi; Lee, Jane J.; Morello, Lauren; Reardon, Sara (December 22, 2016).
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Esmailpour, Taraneh; Riazifar, Hamidreza; Liu, Linan; Donkervoort, Sandra; Huang, Vincent H.; Madaan, Shreshtha; Shoucri, Bassem M.; Busch, Anke; Wu, Jie (March 2014).
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Huang, Taosheng; Atwal, Paldeep S.; Wong, Lee-Jun; Fan, Pi-Chuan; Hwu, Wuh-Liang; Chien, Yin-Hsiu; Chen, Stella Maris; Brown, Jenice; Dell, Sarah (December 18, 2018).
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Peng, Yanyan; Shinde, Deepali N.; Valencia, C. Alexander; Mo, Jun-Song; Rosenfeld, Jill; Truitt Cho, Megan; Chamberlin, Adam; Li, Zhuo; Liu, Jie (December 15, 2017).
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Sherrill, Joseph D.; Kc, Kiran; Wang, Xinjian; Wen, Ting; Chamberlin, Adam; Stucke, Emily M.; Collins, Margaret H.; Abonia, J. Pablo; Peng, Yanyan (April 19, 2018).
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648:(Sherrill et al, 2018, JCI Insight). For these novel disease-causing genes, his group has also established and characterized disease-causing genes with both an
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Li, Zhuo; Peng, Yanyan; Hufnagel, Robert B.; Hu, Yueh-Chiang; Zhao, Chuntao; Queme, Luis F.; Khuchua, Zaza; Driver, Ashley M.; Dong, Fei (October 1, 2017).
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815:"TBX3 and Its Isoform TBX3+2a Are Functionally Distinctive in Inhibition of Senescence and Are Overexpressed in a Subset of Breast Cancer Cell Lines"
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group, Huang’s group demonstrated that mutations of the mitochondrial genome accumulate rapidly with age in somatic tissues, leading to defects in
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Zhang, John; Liu, Hui; Luo, Shiyu; Lu, Zhuo; Chávez-Badiola, Alejandro; Liu, Zitao; Yang, Mingxue; Merhi, Zaher; Silber, Sherman J. (April 2017).
684:(RGCs) (Riazifar et al 2014, Stem cells translational medicine; Chen et al Stem Cell Res Ther, 2016). His studies showed that a single chemical
1167:"A splice donor mutation in NAA10 results in the dysregulation of the retinoic acid signalling pathway and causes Lenz microphthalmia syndrome"
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mode (Luo et al, PNAS, 2018). His results challenge the central dogma of maternal inheritance of mtDNA and strongly support the possibility of
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1224:"Whole-exome sequencing uncovers oxidoreductases DHTKD1 and OGDHL as linkers between mitochondrial dysfunction and eosinophilic esophagitis"
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1108:"Mutations of human NARS2, encoding the mitochondrial asparaginyl-tRNA synthetase, cause nonsyndromic deafness and Leigh syndrome"
757:. Huang’s group is in the process of testing his hypothesis that the mitochondrial dysfunction caused by age-related mutations in
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1338:"Modeling autosomal dominant optic atrophy using induced pluripotent stem cells and identifying potential therapeutic targets"
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Huang has contributed towards basic science and clinical research in human genetics and genetic syndromes, particularly in
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1281:"Loss of SLC25A46 causes neurodegeneration by affecting mitochondrial dynamics and energy production in mice"
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1051:"Biallelic mutations in the ferredoxin reductase gene cause novel mitochondriopathy with optic atrophy"
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Recently, Huang has identified multiple unrelated multi-generation families with a high level of mtDNA
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551:(CLIA)-certified MitoMed Molecular Diagnostics Laboratory, which focused on the molecular basis of
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994:"Mutations in SLC25A46, encoding a UGO1-like protein, cause an optic atrophy spectrum disorder"
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Huang’s laboratory was the very first to develop a novel stepwise, chemical protocol for the
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model to develop a therapy for genetic disease and became the very first group to link
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Chen, Jing; Riazifar, Hamidreza; Guan, Min-Xin; Huang, Taosheng (January 7, 2016).
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870:"Live birth derived from oocyte spindle transfer to prevent mitochondrial disease"
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Huang, Taosheng; Gray, Joe; Chen, Chira; Huang, Xu; Fan, Weiwei (August 1, 2004).
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472:(CCHMC). Huang has published over 100 manuscripts in many impactful journals.
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in the nuclear genome. In addition, ROS was found to influence nuclear DNA
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Differentiated
Retinal Ganglion Cell Derivation from Pluripotent Stem Cells
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Aging
Associated Mitochondrial Mutations and its Epigenetic Consequences
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into functional RGCs. Pre-clinical trials are now on-going in animals.
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with substantial academic achievements and professional experience in
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produced mouse model (Li et al HMG 2017) in order to better study
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583:" which was ranked among the top 10 science stories in 2016 by
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in 2001, he started to explore the molecular basis of genetic
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from the article and its talk page, especially if potentially
722:(Kang et al, Cell Stem Cell, 2016). Increased production of
515:. Upon becoming an independent investigator after moving to
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of mutations in those specific genes. His research on
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University of
California, Irvine School of Medicine
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726:(ROS) due to mitochondrial dysfunction can affect
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567:-produced mouse models in his lab to explore the
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1450:Proceedings of the National Academy of Sciences
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1542:Icahn School of Medicine at Mount Sinai alumni
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470:Cincinnati Children’s Hospital Medical Center
595:Recent Research Work and Notable Discoveries
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53:Learn how and when to remove these messages
16:American geneticist and physician scientist
549:Clinical laboratory improvement amendments
97:about living persons that is unsourced or
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917:Staff, Science News (December 23, 2016).
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302:Learn how and when to remove this message
230:Learn how and when to remove this message
168:Learn how and when to remove this message
600:Discovery of novel disease-causing genes
555:and the identification mutations in the
193:This article includes a list of general
414:Icahn School of Medicine at Mount Sinai
375:Icahn School of Medicine at Mount Sinai
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678:induced pluripotent stem (iPS) cells
608:(Abrams et al, Nat Genet, 2016) and
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742:. Moreover, ROS has the ability to
636:(Esmailpour et al, JMG, 2014), and
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199:it lacks sufficient corresponding
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628:(Simon et al, PLOS Genet, 2015),
575:undertaken in collaboration with
573:mitochondrial replacement therapy
34:This article has multiple issues.
1547:University of Cincinnati faculty
1342:Stem Cell Research & Therapy
699:-positive stem cells to undergo
674:human embryonic stem (hES) cells
517:University of California, Irvine
489:University of California, Irvine
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650:induced pluripotent stem cell
561:induced pluripotent stem cell
483:Upon becoming an independent
1532:American medical researchers
1125:10.1371/journal.pgen.1005097
777:Biparental mtDNA Inheritance
765:production and is linked to
634:Lenz microphthalmia syndrome
466:human mitochondrial genetics
75:biography of a living person
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1171:Journal of Medical Genetics
795:paternal mtDNA transmission
102:must be removed immediately
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1414:10.1016/j.stem.2016.02.005
887:10.1016/j.rbmo.2017.01.013
612:(Peng et al HMG, 2017) in
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670:cellular differentiation
660:and develop treatments.
646:eosinophilic esophagitis
507:Research and discoveries
1471:10.1073/pnas.1810946115
724:reactive oxygen species
513:mitochondrial disorders
261:, as no other articles
214:more precise citations.
711:In collaboration with
682:retinal ganglion cells
533:mitochondrial diseases
519:in 2001, he worked on
462:translational research
429:Harvard Medical School
346:Fujian Province, China
89:Please help by adding
761:results in increased
618:peripheral neuropathy
553:mitochondrial disease
424:Georgetown University
1527:American geneticists
746:gene expression via
557:mitochondrial genome
378:(Ph.D. Degree, 1991)
95:Contentious material
1462:2018PNAS..11513039L
1456:(51): 13039–13044.
961:2016Natur.540..496A
464:, specifically, in
458:physician-scientist
1297:10.1093/hmg/ddx262
1067:10.1093/hmg/ddx377
787:autosomal dominant
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36:Please help
33:
1517:1961 births
1228:JCI Insight
949:Nature News
791:inheritance
769:markers of
751:methylation
740:methylation
736:CpG islands
732:methylation
713:Mitalipov’s
654:CRISPR/Cas9
565:CRISPR/Cas9
563:models and
352:Nationality
212:introducing
1511:Categories
767:epigenetic
748:CpG island
720:metabolism
577:John Zhang
537:Drosophila
531:and other
336:1961-12-20
276:; try the
263:link to it
195:references
128:newspapers
39:improve it
1480:0027-8424
1423:1875-9777
1364:1757-6512
1305:0964-6906
1248:2379-3708
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