367:
344:
266:
241:
632:
625:
618:
373:
272:
2532:, are also infectious with the capability to cross species. Since tau has yet to be proven to be infectious it is not considered to be a true prion but instead a "prion-like" protein. Much like true prions, pathological tau aggregates have been shown to have the capacity to induce misfolding of native tau protein. Both misfolding competent and non-misfolding competent species of tau aggregates have been reported, indicating a highly specific mechanism.
2198:, H1 and H2, in which the gene appears in inverted orientations. Haplogroup H2 is common only in Europe and in people with European ancestry. Haplogroup H1 appears to be associated with increased probability of certain dementias, such as Alzheimer's disease. The presence of both haplogroups in Europe means that recombination between inverted haplotypes can result in the lack of one of the functioning copies of the gene, resulting in congenital defects.
1933:
2418:(NFTs). The stage of the disease determines NFTs' phosphorylation. In AD, at least 19 amino acids are phosphorylated; pre-NFT phosphorylation occurs at serine 199, 202 and 409, while intra-NFT phosphorylation happens at serine 396 and threonine 231. Through its isoforms and phosphorylation, tau protein interacts with tubulin to stabilize microtubule assembly. All of the six tau isoforms are present in an often hyperphosphorylated state in
2277:
tubulin, which in turn enhances fibrilization of tau. Several propagation methods have been proposed that occur by synaptic contact such as synaptic cell adhesion proteins, neuronal activity and other synaptic and non-synaptic mechanisms. The mechanism of tau aggregation is still not completely elucidated, but several factors favor this process, including tau phosphorylation and zinc ions.
2242:. When PKN is activated, it phosphorylates tau, resulting in disruption of microtubule organization. Phosphorylation of tau is also developmentally regulated. For example, fetal tau is more highly phosphorylated in the embryonic CNS than adult tau. The degree of phosphorylation in all six isoforms decreases with age due to the activation of
2425:
Tau mutations have many consequences, including microtubule dysfunction and alteration of the expression level of tau isoforms. Mutations that alter function and isoform expression of tau lead to hyperphosphorylation. The process of tau aggregation in the absence of mutations is not known but might
2276:
The accumulation of hyperphosphorylated tau in neurons is associated with neurofibrillary degeneration. The actual mechanism of how tau propagates from one cell to another is not well identified. Also, other mechanisms, including tau release and toxicity, are unclear. As tau aggregates, it replaces
1944:
technique. MAP2 is found only in dendrites and perikarya, while tau is found not only in the dendrites and perikarya but also in axons. As a result, axons appear red while the dendrites and perikarya appear yellow, due to superimposition of the red and green signals. DNA is shown in blue using the
2453:
Hyperphosphorylated forms of tau protein are the main component of PHFs of NFTs in the brain of AD patients. It has been well demonstrated that regions of tau six-residue segments, namely PHF6 (VQIVYK) and PHF6* (VQIINK), can form tau PHF aggregation in AD. Apart from the PHF6, some other residue
52:
2397:
Gender-specific tau gene expression across different regions of the human brain has recently been implicated in gender differences in the manifestations and risk for tauopathies. Some aspects of how the disease functions also suggest that it has some similarities to
2466:, a component of the pathologic lesion seen in Alzheimer disease. A recent hypothesis identifies the decrease of reelin signaling as the primary change in Alzheimer's disease that leads to the hyperphosphorylation of tau via a decrease in GSK3β inhibition.
2390:, this otherwise very soluble protein can form extremely insoluble aggregates that contribute to a number of neurodegenerative diseases. Tau protein has a direct effect on the breakdown of a living cell caused by tangles that form and block nerve
6831:
Deutsch SI, Rosse RB, Lakshman RM (December 2006). "Dysregulation of tau phosphorylation is a hypothesized point of convergence in the pathogenesis of alzheimer's disease, frontotemporal dementia and schizophrenia with therapeutic implications".
4355:
Matsuo ES, Shin RW, Billingsley ML, Van deVoorde A, O'Connor M, Trojanowski JQ, et al. (October 1994). "Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as
Alzheimer's disease paired helical filament tau".
3935:
Neve RL, Harris P, Kosik KS, Kurnit DM, Donlon TA (December 1986). "Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2".
2214:
of the protein and are positively charged (allowing it to bind to the negatively charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains. Tau is a
2853:
Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA (October 1989). "Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of
Alzheimer's disease".
4012:
Shaw-Smith C, Pittman AM, Willatt L, Martin H, Rickman L, Gribble S, et al. (September 2006). "Microdeletion encompassing MAPT at chromosome 17q21.3 is associated with developmental delay and learning disability".
2073:(a form of non-associative learning), two higher and more integrated physiological functions. Since regulation of tau is critical for memory, this could explain the linkage between tauopathies and cognitive impairment.
2504:(CTE), a condition characterized by fibrillar tangles of hyperphosphorylated tau. After severe traumatic brain injury, high levels of tau protein in extracellular fluid in the brain are linked to poor outcomes.
2454:
sites like Ser285, Ser289, Ser293, Ser305 and Tyr310, located near the C-terminal of the PHF6 sequences, play key roles in the phosphorylation of tau. Hyperphosphorylated tau differs in its sensitivity and its
380:
279:
4460:"Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau"
3745:
Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, et al. (May 2007). "Reducing endogenous tau ameliorates amyloid beta-induced deficits in an
Alzheimer's disease mouse model".
6802:
Hardy J, Pittman A, Myers A, Gwinn-Hardy K, Fung HC, de Silva R, et al. (August 2005). "Evidence suggesting that Homo neanderthalensis contributed the H2 MAPT haplotype to Homo sapiens".
4146:
Hardy J, Pittman A, Myers A, Gwinn-Hardy K, Fung HC, de Silva R, et al. (August 2005). "Evidence suggesting that Homo neanderthalensis contributed the H2 MAPT haplotype to Homo sapiens".
2948:
Shin RW, Iwaki T, Kitamoto T, Tateishi J (May 1991). "Hydrated autoclave pretreatment enhances tau immunoreactivity in formalin-fixed normal and
Alzheimer's disease brain tissues".
5208:
Augustinack JC, Schneider A, Mandelkow EM, Hyman BT (January 2002). "Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in
Alzheimer's disease".
2629:
2187:
has four repeats (R1, R2, R3 and R4) and two inserts (441 amino acids total), while the shortest isoform has three repeats (R1, R3 and R4) and no insert (352 amino acids total).
6668:
van
Swieten JC, Rosso SM, van Herpen E, Kamphorst W, Ravid R, Heutink P (2004). "Phenotypic variation in frontotemporal dementia and parkinsonism linked to chromosome 17".
4569:
3148:
Harada A, Oguchi K, Okabe S, Kuno J, Terada S, Ohshima T, et al. (June 1994). "Altered microtubule organization in small-calibre axons of mice lacking tau protein".
2796:"Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau"
3015:
Cleveland DW, Hwo SY, Kirschner MW (October 1977). "Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin".
2076:
In mice, while the reported tau knockout strains present without overt phenotype when young, when aged, they show some muscle weakness, hyperactivity, and impaired
5909:"Tau elevations in the brain extracellular space correlate with reduced amyloid-β levels and predict adverse clinical outcomes after severe traumatic brain injury"
6869:
Williams DR (October 2006). "Tauopathies: classification and clinical update on neurodegenerative diseases associated with microtubule-associated protein tau".
3050:
Cleveland DW, Hwo SY, Kirschner MW (October 1977). "Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly".
5766:
Omalu BI, DeKosky ST, Minster RL, Kamboh MI, Hamilton RL, Wecht CH (July 2005). "Chronic traumatic encephalopathy in a
National Football League player".
6306:"Interactions between the microtubule-associated tau proteins and S100b regulate tau phosphorylation by the Ca2+/calmodulin-dependent protein kinase II"
1340:
202:
6763:
Lee HG, Perry G, Moreira PI, Garrett MR, Liu Q, Zhu X, et al. (April 2005). "Tau phosphorylation in
Alzheimer's disease: pathogen or protector?".
4943:
Lee HG, Perry G, Moreira PI, Garrett MR, Liu Q, Zhu X, et al. (April 2005). "Tau phosphorylation in
Alzheimer's disease: pathogen or protector?".
2382:. All of the six tau isoforms are present in an often hyperphosphorylated state in paired helical filaments in the Alzheimer's disease brain. In other
1321:
7154:
2414:
states that excessive or abnormal phosphorylation of tau results in the transformation of normal adult tau into paired-helical-filament (PHF) tau and
1967:
Tau proteins are found more often in neurons than in non-neuronal cells in humans. One of tau's main functions is to modulate the stability of axonal
1925:. The tau proteins were identified in 1975 as heat-stable proteins essential for microtubule assembly, and since then they have been characterized as
4183:"Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration"
2227:(Thr) phosphorylation sites on the longest tau isoform. Phosphorylation has been reported on approximately 30 of these sites in normal tau proteins.
3098:"Drosophila Tau Negatively Regulates Translation and Olfactory Long-Term Memory, But Facilitates Footshock Habituation and Cytoskeletal Homeostasis"
5061:"Gender-Specific Expression of Ubiquitin-Specific Peptidase 9 Modulates Tau Expression and Phosphorylation: Possible Implications for Tauopathies"
7203:
5971:
Dujardin S, Hyman BT (2019). "Tau Prion-Like
Propagation: State of the Art and Current Challenges". In Takashima A, Wolozin B, Buee L (eds.).
3702:
Ikegami S, Harada A, Hirokawa N (February 2000). "Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice".
2714:
2696:
6565:
Blennow K, Vanmechelen E, Hampel H (2002). "CSF total tau, Abeta42 and phosphorylated tau protein as biomarkers for Alzheimer's disease".
2438:. Hyperphosphorylated tau disassembles microtubules and sequesters normal tau, MAPT 1 (microtubule associated protein tau 1), MAPT 2 and
2297:
mutations that change the extracellular level of tau. According to Asai and his colleagues, the spreading of tau protein occurs from the
9012:
6427:
Morishima-Kawashima M, Hasegawa M, Takio K, Suzuki M, Yoshida H, Watanabe A, et al. (1995). "Hyperphosphorylation of tau in PHF".
2560:
1783:
6726:
Rademakers R, Cruts M, van Broeckhoven C (October 2004). "The role of tau (MAPT) in frontotemporal dementia and related tauopathies".
1776:
9032:
2333:. The degree of toxicity is affected by different factors, such as the degree of microtubule binding. Toxicity could also happen by
2293:. On the other hand, tau release depends on neuronal activity. Many factors influence tau release, for example, type of isoforms or
2175:
with a range of 352–441 amino acids. Tau isoforms are different in having either zero, one, or two inserts of 29 amino acids at the
8964:
8949:
8944:
8939:
8934:
8924:
8845:
8554:
8534:
8504:
8499:
5441:"Alzheimer disease A68 proteins injected into rat brain induce codeposits of beta-amyloid, ubiquitin, and alpha 1-antichymotrypsin"
2210:. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the
9174:
9169:
9164:
9159:
8914:
8904:
8894:
8889:
8860:
8564:
8559:
7606:
7494:
7484:
7459:
7439:
7343:
7323:
4271:
Kanemaru K, Takio K, Miura R, Titani K, Ihara Y (May 1992). "Fetal-type phosphorylation of the tau in paired helical filaments".
2975:
Lei P, Ayton S, Finkelstein DI, Adlard PA, Masters CL, Bush AI (November 2010). "Tau protein: relevance to Parkinson's disease".
2480:
blood test for the p-tau-217 form of the protein could diagnose Alzheimer's up to decades before dementia symptoms were evident.
2001:
to stabilize microtubules and promote tubulin assembly into microtubules. Tau has two ways of controlling microtubule stability:
2285:
Tau involves in uptake and release process, which is known as seeding. Uptake of tau protein mechanism requires the presence of
7566:
6124:"alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356"
1990:
4847:"PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila"
9518:
6937:
Roder HM, Hutton ML (April 2007). "Microtubule-associated protein tau as a therapeutic target in neurodegenerative disease".
5988:
6390:
Goedert M, Crowther RA, Garner CC (May 1991). "Molecular characterization of microtubule-associated proteins tau and MAP2".
2679:
7831:
2239:
49:
2658:
173:, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU, microtubule associated protein tau, Tau proteins, tau-40
7196:
6705:
Kowalska A, Jamrozik Z, Kwieciński H (2004). "Progressive supranuclear palsy--parkinsonian disorder with tau pathology".
3202:
Wang JZ, Liu F (June 2008). "Microtubule-associated protein tau in development, degeneration and protection of neurons".
1982:
that did not show abnormalities in brain development – possibly because of compensation in tau deficiency by other MAPs.
2317:
Tau causes toxic effects through its accumulation inside cells. Many enzymes are involved in toxicity mechanism such as
366:
2321:
kinase. This enzyme stimulates phosphorylation of serine 262 and 356, which in turn leads to activate other kinases (
1926:
4655:"The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?"
2528:
are defined by their ability to induce misfolding of native proteins to perpetuate the pathology. True prions, like
2501:
343:
6208:"Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau"
5498:
Vincent IJ, Davies P (October 1990). "Phosphorylation characteristics of the A68 protein in Alzheimer's disease".
8350:
2683:
2662:
1975:
6257:"S100beta interaction with tau is promoted by zinc and inhibited by hyperphosphorylation in Alzheimer's disease"
3846:
2171:, which leads to the formation of six tau isoforms. In the human brain, tau proteins constitute a family of six
8619:
8462:
7189:
5339:"Structure Based Design and Molecular Docking Studies for Phosphorylated Tau Inhibitors in Alzheimer's Disease"
4990:"Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments"
2614:
1867:
1393:
2659:
ENSG00000276155, ENSG00000277956 GRCh38: Ensembl release 89: ENSG00000186868, ENSG00000276155, ENSG00000277956
9498:
9052:
5701:"Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders"
5059:
Köglsberger S, Cordero-Maldonado ML, Antony P, Forster JI, Garcia P, Buttini M, et al. (December 2017).
4107:"H1 tau haplotype-related genomic variation at 17q21.3 as an Asian heritage of the European Gypsy population"
2601:
2318:
2286:
265:
240:
7149:
3458:"Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis"
1374:
1370:
1366:
2092:
1890:
has the highest abundance. They are less common elsewhere but are also expressed at very low levels in CNS
182:
5294:
Mudher A, Lovestone S (January 2002). "Alzheimer's disease-do tauists and baptists finally shake hands?".
4896:"Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model"
4316:"The phosphorylation state of tau in the developing rat brain is regulated by phosphoprotein phosphatases"
7759:
6602:
Ingram EM, Spillantini MG (December 2002). "Tau gene mutations: dissecting the pathogenesis of FTDP-17".
5811:"Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model"
3096:
Papanikolopoulou K, Roussou IG, Gouzi JY, Samiotaki M, Panayotou G, Turin L, et al. (October 2019).
2541:
1997:, where it provides microtubule stabilization but also flexibility as needed. Tau proteins interact with
9230:
5616:
3398:"Decreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling"
2383:
2119:. Atypical, non-standard roles of tau are also under current investigation, such as its involvement in
379:
278:
2609:
372:
271:
6026:
2246:. Like kinases, phosphatases too play a role in regulating the phosphorylation of tau. For example,
2206:
Six tau isoforms exist in human brain tissue, and they are distinguished by their number of binding
169:
9463:
7143:
5699:
Palmqvist S, Janelidze S, Quiroz YT, Zetterberg H, Lopera F, Stomrud E, et al. (August 2020).
3884:
Sotiropoulos I, Galas MC, Silva JM, Skoulakis E, Wegmann S, Maina MB, et al. (November 2017).
3245:
Ke YD, Suchowerska AK, van der Hoven J, De Silva DM, Wu CW, van Eersel J, et al. (June 2012).
2164:
1759:
1755:
1751:
1747:
1743:
1739:
1735:
1731:
1727:
1723:
1719:
1715:
1711:
1707:
1703:
1699:
1695:
1691:
1687:
1683:
1679:
1675:
1671:
1667:
1663:
1659:
1655:
1641:
1637:
1633:
1629:
1614:
1610:
1606:
1602:
1576:
1572:
1568:
1564:
1544:
1540:
1536:
1528:
1507:
1503:
1499:
1495:
1469:
1465:
1461:
1457:
190:
4653:
Fichou Y, Al-Hilaly YK, Devred F, Smet-Nocca C, Tsvetkov PO, Verelst J, et al. (March 2019).
3456:
Meier S, Bell M, Lyons DN, Rodriguez-Rivera J, Ingram A, Fontaine SN, et al. (January 2016).
5858:
McKee AC, Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH, et al. (January 2013).
3653:
2521:
2375:
1922:
5907:
Magnoni S, Esparza TJ, Conte V, Carbonara M, Carrabba G, Holtzman DM, et al. (April 2012).
5251:
van Slegtenhorst M, Lewis J, Hutton M (July 2000). "The molecular genetics of the tauopathies".
4568:
Calafate S, Buist A, Miskiewicz K, Vijayan V, Daneels G, de Strooper B, et al. (May 2015).
1645:
1598:
1594:
1590:
1580:
1532:
1491:
1487:
1483:
1473:
4401:"O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease"
2596:
2517:
2489:
2415:
2371:
2363:
2334:
2184:
1989:
at low levels, where it is involved in postsynaptic scaffolding, it is active primarily in the
1914:
1910:
1883:
6511:"Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease"
4056:
Zody MC, Jiang Z, Fung HC, Antonacci F, Hillier LW, Cardone MF, et al. (September 2008).
3298:"Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models"
2897:
Sjölin K, Kultima K, Larsson A, Freyhult E, Zjukovskaja C, Alkass K, et al. (June 2022).
2258:
Ser396. The binding of these phosphatases to tau affects tau's association with microtubules.
7882:
7236:
5809:
Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, et al. (May 2012).
4230:
Taniguchi T, Kawamata T, Mukai H, Hasegawa H, Isagawa T, Yasuda M, et al. (March 2001).
2156:
2029:
254:
5388:
Tepper K, Biernat J, Kumar S, Wegmann S, Timm T, Hübschmann S, et al. (December 2014).
4612:
Roman AY, Devred F, Byrne D, La Rocca R, Ninkina NN, Peyrot V, et al. (February 2019).
3796:
Dawson HN, Cantillana V, Jansen M, Wang H, Vitek MP, Wilcock DM, et al. (August 2010).
2512:
The term "prion-like" is often used to describe several aspects of tau pathology in various
8151:
5452:
5001:
4471:
4412:
3754:
3157:
2807:
2748:
2591:
2470:
2459:
2351:
2168:
2054:
2043:
1856:
3615:"Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice"
210:
8:
9458:
8091:
4105:
Almos PZ, Horváth S, Czibula A, Raskó I, Sipos B, Bihari P, et al. (November 2008).
2013:
1950:
1918:
7139:
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5049:"Alzheimer's Brain Tangles." Alzheimer's Association, www.alz.org/braintour/tangles.asp.
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4796:
Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, et al. (November 2015).
4722:
4705:
4475:
4416:
3758:
3564:
Koren SA, Hamm MJ, Meier SE, Weiss BE, Nation GK, Chishti EA, et al. (April 2019).
3296:
Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J, et al. (August 2010).
3161:
2811:
2752:
2386:, the deposition of aggregates enriched in certain tau isoforms has been reported. When
2012:
In addition to its microtubule-stabilizing function, Tau has also been found to recruit
7911:
7541:
7115:
7090:
7051:
7026:
7013:
7000:
6975:
6962:
6894:
6857:
6751:
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6590:
6452:
6415:
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6272:
6256:
6232:
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6188:
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6002:
5933:
5908:
5884:
5859:
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5791:
5779:
5748:
5725:
5700:
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5649:
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5523:
5416:
5389:
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5338:
5319:
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5233:
5185:
5158:
5134:
5109:
5085:
5060:
4920:
4895:
4876:
4822:
4797:
4773:
4746:
4681:
4654:
4545:
4518:
4381:
4296:
4284:
4207:
4182:
4082:
4057:
4038:
3912:
3885:
3822:
3813:
3797:
3778:
3727:
3681:
3590:
3565:
3541:
3506:
3482:
3457:
3430:
3397:
3327:
3273:
3246:
3227:
3181:
3122:
3097:
2925:
2898:
2879:
2435:
1941:
214:
6615:
6527:
6510:
6322:
6305:
5543:"Relevance of a Novel Circuit-Level Model of Episodic Memories to Alzheimer's Disease"
5307:
5264:
4863:
4846:
4435:
4400:
4332:
4315:
3845:
Cantero JL, Hita-Yañez E, Moreno-Lopez B, Portillo F, Rubio A, Avila J (August 2010).
3715:
3373:
3346:
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949:
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919:
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743:
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723:
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678:
673:
9523:
9309:
7673:
7170:
7161:
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7077:
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7005:
6991:
6954:
6925:
6886:
6882:
6849:
6819:
6790:
6743:
6714:
6685:
6648:
6619:
6582:
6553:
6532:
6497:
6444:
6440:
6407:
6403:
6368:
6327:
6286:
6237:
6180:
6163:
Giasson BI, Lee VM, Trojanowski JQ (2003). "Interactions of amyloidogenic proteins".
6145:
6104:
6063:
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5994:
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5938:
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5840:
5795:
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4494:
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4288:
4253:
4212:
4163:
4128:
4087:
4030:
3994:
3953:
3949:
3917:
3866:
3827:
3770:
3719:
3673:
3634:
3595:
3546:
3528:
3487:
3435:
3417:
3378:
3319:
3278:
3219:
3173:
3127:
3067:
3063:
3032:
3028:
2992:
2957:
2930:
2871:
2867:
2835:
2776:
2624:
2497:
2309:
were also involved in the transport process, and their actual role is still unknown.
2298:
2235:
2140:
2077:
2050:
162:
42:
7017:
6966:
6898:
6755:
6697:
6660:
6594:
6456:
6419:
5527:
5323:
5280:
4880:
4613:
4385:
4300:
4042:
3782:
3731:
3685:
3331:
3231:
3215:
2883:
9257:
8381:
7736:
7731:
7110:
7102:
7046:
7038:
6995:
6987:
6946:
6915:
6878:
6861:
6841:
6811:
6780:
6772:
6735:
6677:
6640:
6611:
6574:
6522:
6487:
6477:
6436:
6399:
6358:
6317:
6276:
6268:
6227:
6219:
6192:
6172:
6135:
6094:
6053:
5976:
5928:
5920:
5879:
5871:
5830:
5822:
5775:
5720:
5712:
5671:
5661:
5564:
5554:
5507:
5470:
5460:
5411:
5401:
5360:
5350:
5303:
5260:
5237:
5217:
5180:
5170:
5129:
5121:
5080:
5072:
5019:
5009:
4960:
4952:
4915:
4907:
4858:
4817:
4809:
4768:
4758:
4717:
4676:
4666:
4625:
4584:
4540:
4530:
4489:
4479:
4430:
4420:
4365:
4327:
4280:
4243:
4202:
4194:
4155:
4118:
4077:
4069:
4022:
3984:
3945:
3907:
3897:
3858:
3817:
3809:
3762:
3711:
3665:
3626:
3585:
3577:
3536:
3518:
3477:
3473:
3469:
3425:
3409:
3368:
3358:
3309:
3268:
3258:
3211:
3185:
3165:
3117:
3113:
3109:
3059:
3024:
2984:
2920:
2910:
2863:
2825:
2815:
2766:
2756:
2447:
2355:
2290:
2127:, its interaction with other cytoskeletal or synaptic proteins, its involvement in
2108:
2088:
2066:
2017:
1852:
459:
390:
334:
289:
7027:"Functional MAPT haplotypes: bridging the gap between genotype and neuropathology"
5650:"Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer's disease"
4314:
Mawal-Dewan M, Henley J, Van de Voorde A, Trojanowski JQ, Lee VM (December 1994).
2899:"Distribution of five clinically important neuroglial proteins in the human brain"
194:
9399:
8013:
7863:
7746:
6776:
6206:
Klein C, Kramer EM, Cardine AM, Schraven B, Brandt R, Trotter J (February 2002).
6058:
6041:
5980:
5826:
4956:
4798:"Depletion of microglia and inhibition of exosome synthesis halt tau propagation"
4589:
3989:
3972:
3798:"Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease"
3669:
2988:
2548:
2473:
form of tau protein found in the brains of individuals with Alzheimer's disease.
2387:
2330:
2255:
2172:
2112:
2080:. However, neither spatial learning in mice, nor short-term memory (learning) in
2006:
2002:
1895:
1887:
434:
218:
6845:
6578:
6122:
Jensen PH, Hager H, Nielsen MS, Hojrup P, Gliemann J, Jakes R (September 1999).
3654:"14-3-3 proteins and protein phosphatases are not reduced in tau-deficient mice"
3614:
2719:
National Center for Biotechnology Information, U.S. National Library of Medicine
2701:
National Center for Biotechnology Information, U.S. National Library of Medicine
1021:
activation of cysteine-type endopeptidase activity involved in apoptotic process
9362:
9225:
7922:
7753:
7262:
7181:
6176:
6099:
6082:
5445:
Proceedings of the National Academy of Sciences of the United States of America
4994:
Proceedings of the National Academy of Sciences of the United States of America
4464:
Proceedings of the National Academy of Sciences of the United States of America
4405:
Proceedings of the National Academy of Sciences of the United States of America
3613:
Dawson HN, Ferreira A, Eyster MV, Ghoshal N, Binder LI, Vitek MP (March 2001).
3581:
3523:
3314:
3297:
2915:
2800:
Proceedings of the National Academy of Sciences of the United States of America
2741:
Proceedings of the National Academy of Sciences of the United States of America
2493:
2411:
2216:
2211:
2207:
2136:
2104:
1906:
535:
7042:
6950:
5951:
5076:
4747:"Extracellular Tau and Its Potential Role in the Propagation of Tau Pathology"
4671:
4630:
3902:
2366:
of paired helical filaments and straight filaments, which are involved in the
9512:
9426:
9421:
8386:
8256:
8205:
8155:
8095:
8017:
7985:
7926:
7712:
7231:
6140:
6123:
6042:"Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis"
5628:
4763:
3566:"Tau drives translational selectivity by interacting with ribosomal proteins"
3532:
3421:
3413:
2529:
2359:
2124:
1979:
1136:
negative regulation of establishment of protein localization to mitochondrion
660:
631:
624:
617:
6631:
Pickering-Brown S (2004). "The tau gene locus and frontotemporal dementia".
5716:
5465:
5406:
5175:
4425:
3886:"Atypical, non-standard functions of the microtubule associated Tau protein"
3862:
3766:
3363:
2820:
595:
473:
9270:
8325:
8080:
7624:
7216:
7106:
7091:"Tau proteins: the molecular structure and mode of binding on microtubules"
7081:
7060:
7009:
6958:
6929:
6890:
6853:
6823:
6794:
6747:
6718:
6689:
6652:
6623:
6586:
6557:
6536:
6501:
6372:
6363:
6346:
6290:
6241:
6184:
6149:
6108:
6067:
5998:
5942:
5924:
5893:
5875:
5844:
5787:
5734:
5685:
5578:
5425:
5374:
5315:
5272:
5229:
5194:
5143:
5094:
5033:
5014:
4974:
4929:
4872:
4831:
4782:
4731:
4690:
4639:
4598:
4554:
4535:
4444:
4257:
4248:
4231:
4167:
4132:
4091:
4034:
3998:
3921:
3870:
3831:
3774:
3723:
3677:
3638:
3630:
3599:
3550:
3491:
3439:
3382:
3323:
3282:
3223:
3131:
2996:
2934:
2761:
2463:
2367:
1871:
452:
231:
9242:
9220:
7124:
6482:
6448:
6411:
6331:
5519:
5484:
5221:
4503:
4484:
4377:
4341:
4292:
4216:
3957:
3263:
3177:
2961:
2875:
2839:
2780:
2476:
In 2020, researchers from two groups published studies indicating that an
1823:
1818:
9416:
9367:
9237:
8457:
7901:
7856:
7775:
7697:
7245:
6920:
6907:
5666:
5559:
5355:
5058:
4911:
4313:
3071:
3036:
2619:
2513:
2477:
2443:
2302:
2243:
2128:
2070:
1968:
1438:
1419:
4519:"Propagation of tau misfolding from the outside to the inside of a cell"
4123:
4106:
3652:
Fujio K, Sato M, Uemura T, Sato T, Sato-Harada R, Harada A (July 2007).
9468:
9387:
9377:
9265:
8376:
8355:
8121:
8058:
8053:
8048:
8028:
8003:
7991:
7977:
7972:
7967:
7962:
7957:
7952:
7947:
7942:
7937:
7799:
7681:
7670:
7656:
7272:
7068:
Delacourte A (2005). "Tauopathies: recent insights into old diseases".
6815:
6739:
5952:"High levels of tau protein linked to poor recovery after brain injury"
4159:
2431:
2195:
2180:
2176:
2120:
2034:
351:
248:
198:
6908:"Untangling the tau gene association with neurodegenerative disorders"
6785:
6681:
6644:
6426:
5617:"'Amazing, Isn't It?' Long-Sought Blood Test for Alzheimer's in Reach"
5125:
4965:
4198:
2950:
Laboratory Investigation; A Journal of Technical Methods and Pathology
1932:
139:
135:
131:
127:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
83:
79:
75:
71:
9297:
9292:
9287:
9247:
9085:
9080:
9075:
8433:
8413:
8068:
8063:
8043:
8038:
8033:
8023:
7932:
7836:
7770:
6492:
3844:
3169:
3095:
2585:
2439:
2419:
2379:
2346:
2306:
2224:
2116:
1986:
1891:
1285:
418:
405:
317:
304:
206:
4813:
4614:"Zinc Induces Temperature-Dependent Reversible Self-Assembly of Tau"
3396:
Evans HT, Benetatos J, van Roigen M, Bodea LG, Götz J (2019-07-01).
2469:
A68 is a name sometimes given (mostly in older publications) to the
2305:
region in the early stages of the disease. They also suggested that
2065:
The primary non-cellular functions of tau is to negatively regulate
9411:
9372:
9304:
9277:
9144:
9132:
9007:
9002:
8443:
8438:
8360:
7794:
7789:
7651:
6667:
4073:
4026:
2794:
Goedert M, Wischik CM, Crowther RA, Walker JE, Klug A (June 1988).
2427:
2391:
2262:
2039:
1902:
1807:
5698:
5207:
4988:
Alonso A, Zaidi T, Novak M, Grundke-Iqbal I, Iqbal K (June 2001).
4570:"Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation"
3244:
2261:
Phosphorylation of tau has also been suggested to be regulated by
1936:
Neurons were grown in tissue culture and stained with antibody to
9438:
9392:
9282:
9212:
9181:
9111:
9106:
9070:
9065:
9060:
9027:
8997:
8992:
8987:
8982:
8667:
8599:
8594:
8589:
8584:
8579:
8471:
8408:
7896:
7841:
7782:
7765:
7726:
7212:
7175:
7165:
6976:"Hereditary frontotemporal dementia caused by Tau gene mutations"
4354:
3505:
Evans HT, Taylor D, Kneynsberg A, Bodea LG, Götz J (2021-06-19).
2852:
2132:
1998:
1405:
1352:
1270:
1266:
6834:
Progress in Neuro-Psychopharmacology & Biological Psychiatry
6515:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
5390:"Oligomer formation of tau protein hyperphosphorylated in cells"
3977:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
3507:"Altered ribosomal function and protein synthesis caused by tau"
2630:
Frontotemporal dementia and parkinsonism linked to chromosome 17
1870:
tau). They have roles primarily in maintaining the stability of
186:
9357:
9339:
9334:
9329:
9324:
9314:
9149:
9042:
9037:
9022:
9017:
8929:
8875:
8840:
8815:
8810:
8805:
8800:
8790:
8785:
8775:
8760:
8755:
8637:
8632:
8627:
8539:
8529:
8509:
8494:
8489:
8484:
8479:
8345:
8116:
8111:
7868:
7534:
7529:
7519:
7297:
6465:
4652:
4399:
Liu F, Iqbal K, Grundke-Iqbal I, Hart GW, Gong CX (July 2004).
3883:
2455:
2254:
are both present in human brain tissue and have the ability to
2231:
2220:
1879:
1791:
1307:
1256:
cellular response to brain-derived neurotrophic factor stimulus
640:
6725:
4894:
Chatterjee S, Sang TK, Lawless GM, Jackson GR (January 2009).
4567:
4458:
Alonso AD, Grundke-Iqbal I, Barra HS, Iqbal K (January 1997).
4229:
4011:
3455:
2734:
2588:, a class of diseases associated with accumulated tau proteins
2500:, and the concussive force of military blasts. It can lead to
9382:
9154:
9137:
8974:
8969:
8959:
8954:
8919:
8909:
8899:
8884:
8865:
8855:
8850:
8835:
8830:
8825:
8820:
8795:
8780:
8770:
8765:
8750:
8745:
8725:
8720:
8715:
8710:
8705:
8700:
8695:
8690:
8685:
8680:
8675:
8647:
8642:
8609:
8604:
8574:
8569:
8549:
8544:
8524:
8514:
8429:
8307:
8302:
8297:
8292:
8287:
8282:
8277:
8272:
8267:
8262:
8246:
8241:
8236:
8231:
8226:
8221:
8216:
8211:
8186:
8181:
8176:
8171:
8166:
8161:
8141:
8136:
8131:
8126:
8106:
8101:
7811:
7741:
7690:
7687:
7684:
7676:
7665:
7662:
7659:
7644:
7639:
7634:
7629:
7601:
7591:
7576:
7509:
7499:
7479:
7454:
7449:
7434:
7424:
7419:
7414:
7409:
7404:
7399:
7384:
7338:
7333:
7328:
7318:
7313:
7308:
7287:
7282:
7277:
7267:
7254:
5860:"The spectrum of disease in chronic traumatic encephalopathy"
4987:
4457:
4058:"Evolutionary toggling of the MAPT 17q21.31 inversion region"
3744:
3395:
2735:
Weingarten MD, Lockwood AH, Hwo SY, Kirschner MW (May 1975).
2634:
2571:
2565:
2525:
2399:
2322:
2042:, which results in impaired ribosomal function, reduction of
1994:
1875:
7160:
Overview of all the structural information available in the
6801:
5906:
5648:
Barthélemy NR, Horie K, Sato C, Bateman RJ (November 2020).
4893:
4145:
2977:
The International Journal of Biochemistry & Cell Biology
2896:
2793:
1186:
regulation of microtubule polymerization or depolymerization
9483:
9478:
9473:
9433:
9404:
9319:
9196:
9191:
9186:
9090:
8740:
8735:
8730:
8657:
8652:
8519:
8401:
8396:
8391:
7851:
7846:
7804:
7717:
7707:
7702:
7596:
7586:
7581:
7571:
7561:
7556:
7551:
7546:
7469:
7394:
7389:
7379:
7374:
7369:
7364:
7359:
7354:
5439:
Shin RW, Bramblett GT, Lee VM, Trojanowski JQ (July 1993).
5438:
5250:
3612:
2326:
2251:
2247:
2160:
1946:
1937:
1860:
6704:
6347:"14-3-3zeta is an effector of tau protein phosphorylation"
6205:
5647:
3795:
3504:
1978:(MAPs) may perform similar functions, as suggested by tau
5975:. Vol. 1184. Singapore: Springer. pp. 305–325.
5808:
5765:
5387:
5156:
4398:
2974:
2947:
2554:
2337:(NFTs), which leads to cell death and cognitive decline.
16:
Group of six protein isoforms produced from the MAPT gene
6564:
6543:
6121:
4703:
4611:
4270:
4104:
3973:"Tau protein as a differential biomarker of tauopathies"
3347:"The MAP2/Tau family of microtubule-associated proteins"
2405:
2179:(exons 2 and 3) and three or four repeat-regions at the
442:
7150:
GeneReviews/NCBI/NIH/UW entry on MAPT-Related Disorders
5857:
4795:
2442:
into tangles of PHFs. This insoluble structure damages
1096:
plus-end-directed organelle transport along microtubule
1036:
negative regulation of mitochondrial membrane potential
6973:
6762:
6546:
Seikagaku. The Journal of Japanese Biochemical Society
4942:
4055:
3970:
1126:
positive regulation of protein localization to synapse
7088:
6389:
6344:
6162:
4706:"Propagation of Tau Aggregates and Neurodegeneration"
3934:
3701:
3147:
3049:
3014:
2737:"A protein factor essential for microtubule assembly"
1141:
positive regulation of diacylglycerol kinase activity
607:
6830:
6544:
Morishima-Kawashima M, Ihara Y (November 2001). "".
5157:
Mohandas E, Rajmohan V, Raghunath B (January 2009).
2507:
7024:
6905:
3651:
3563:
2091:, with increased wakefulness periods and decreased
1221:
regulation of microtubule cytoskeleton organization
6508:
4704:Goedert M, Eisenberg DS, Crowther RA (July 2017).
4180:
2675:
2673:
2671:
2654:
2652:
2650:
2038:, mouse, and human brains, through its binding to
1949:stain which highlights the nuclei. Image courtesy
1917:are associated with tau proteins that have become
1056:positive regulation of superoxide anion generation
6601:
5336:
4516:
3971:Sergeant N, Delacourte A, Buée L (January 2005).
3295:
3010:
3008:
3006:
2230:Phosphorylation of tau is regulated by a host of
2183:part (exon 10). Thus, the longest isoform in the
2053:, including the crucial regulator of translation
1251:cellular response to nerve growth factor stimulus
1001:positive regulation of microtubule polymerization
389:
288:
9510:
7211:
7089:Hirokawa N, Shiomura Y, Okabe S (October 1988).
6906:Pittman AM, Fung HC, de Silva R (October 2006).
6345:Hashiguchi M, Sobue K, Paudel HK (August 2000).
6080:
739:minor groove of adenine-thymine-rich DNA binding
6630:
6083:"[Prion-like Propagation Model of Tau]"
5293:
5110:"Is tau ready for admission to the prion club?"
4844:
3091:
3089:
3087:
3085:
3083:
3081:
2668:
2647:
6974:van Swieten J, Spillantini MG (January 2007).
6914:. 15. 15 Spec No 2 (Review Issue 2): R188-95.
3344:
3197:
3195:
3003:
2680:GRCm38: Ensembl release 89: ENSMUSG00000018411
2268:modification at various Ser and Thr residues.
2163:. The major tau protein in the human brain is
1940:protein in green and MAP tau in red using the
7197:
5970:
5497:
5052:
2730:
2728:
2123:stability, its interaction with the cellular
2087:In addition, tau knockout mice have abnormal
1146:regulation of response to DNA damage stimulus
7174:(Microtubule-associated protein tau) at the
6338:
6248:
6199:
6156:
6115:
5900:
5381:
5101:
4981:
4232:"Phosphorylation of tau is regulated by PKN"
4223:
4139:
4098:
4049:
4005:
3251:International Journal of Alzheimer's Disease
3078:
2968:
2155:gene for encoding tau protein is located on
2084:seems to be affected by the absence of tau.
1962:
1241:negative regulation of tubulin deacetylation
1201:cellular response to reactive oxygen species
1106:negative regulation of mitochondrial fission
6936:
6303:
6297:
5547:International Journal of Molecular Sciences
4348:
4307:
4264:
4174:
3192:
1236:positive regulation of protein localization
1231:regulation of long-term synaptic depression
7204:
7190:
7067:
6670:Dementia and Geriatric Cognitive Disorders
6633:Dementia and Geriatric Cognitive Disorders
5107:
4517:Frost B, Jacks RL, Diamond MI (May 2009).
2941:
2846:
2787:
2725:
2561:Proto-oncogene tyrosine-protein kinase Src
1076:intracellular distribution of mitochondria
7142:at the U.S. National Library of Medicine
7114:
7050:
6999:
6919:
6784:
6526:
6491:
6481:
6362:
6321:
6280:
6231:
6139:
6098:
6057:
5932:
5883:
5834:
5724:
5675:
5665:
5568:
5558:
5474:
5464:
5415:
5405:
5364:
5354:
5184:
5174:
5133:
5084:
5023:
5013:
4964:
4919:
4862:
4821:
4772:
4762:
4721:
4680:
4670:
4629:
4588:
4544:
4534:
4493:
4483:
4434:
4424:
4331:
4247:
4206:
4122:
4081:
3988:
3911:
3901:
3821:
3589:
3540:
3522:
3481:
3429:
3372:
3362:
3313:
3272:
3262:
3121:
2924:
2914:
2829:
2819:
2770:
2760:
2483:
1181:central nervous system neuron development
1166:regulation of signaling receptor activity
804:phosphatidylinositol bisphosphate binding
7025:Caffrey TM, Wade-Martins R (July 2007).
6868:
6254:
5337:Pradeepkiran JA, Reddy PH (March 2019).
4845:Nishimura I, Yang Y, Lu B (March 2004).
2340:
2049:Tau interacts specifically with several
1931:
1851:nit) form a group of six highly soluble
1086:regulation of calcium-mediated signaling
996:regulation of microtubule polymerization
6509:Goedert M, Spillantini MG (July 2000).
6463:
5614:
4181:Billingsley ML, Kincaid RL (May 1997).
3201:
2426:result from increased phosphorylation,
2135:signaling, its role in the exposure to
2103:Other typical functions of tau include
1151:internal protein amino acid acetylation
1116:regulation of cellular response to heat
9511:
5949:
5540:
4744:
3847:"Tau protein role in sleep-wake cycle"
1171:negative regulation of gene expression
1061:negative regulation of kinase activity
764:protein-macromolecule adaptor activity
7185:
6939:Expert Opinion on Therapeutic Targets
6081:Hosokawa M, Hasegawa M (2019-07-01).
6039:
5159:"Neurobiology of Alzheimer's disease"
5045:
5043:
3697:
3695:
3451:
3449:
3143:
3141:
2406:Tau hypothesis of Alzheimer's disease
2289:at the cell surface, which happen by
2018:microtubule-mediated axonal transport
1191:regulation of chromosome organization
1011:microtubule cytoskeleton organization
1006:positive regulation of axon extension
865:cytoplasmic ribonucleoprotein granule
394:
355:
350:
293:
252:
247:
5654:The Journal of Experimental Medicine
4659:Acta Neuropathologica Communications
3890:Acta Neuropathologica Communications
3511:Acta Neuropathologica Communications
2093:non-rapid eye movements (NREM) sleep
2028:Tau is a negative regulator of mRNA
1046:cytoplasmic microtubule organization
6351:The Journal of Biological Chemistry
6310:The Journal of Biological Chemistry
6128:The Journal of Biological Chemistry
5394:The Journal of Biological Chemistry
4723:10.1146/annurev-neuro-072116-031153
4523:The Journal of Biological Chemistry
4320:The Journal of Biological Chemistry
4236:The Journal of Biological Chemistry
2167:by 11 exons. Exons 2, 3 and 10 are
2023:
1121:positive regulation of neuron death
1101:regulation of mitochondrial fission
13:
6382:
6273:10.1523/JNEUROSCI.21-07-02240.2001
6224:10.1523/JNEUROSCI.22-03-00698.2002
5956:Washington University in St. Louis
5780:10.1227/01.NEU.0000163407.92769.ED
5040:
4285:10.1111/j.1471-4159.1992.tb10039.x
3814:10.1016/j.neuroscience.2010.04.037
3692:
3446:
3138:
2098:
930:intracellular anatomical structure
554:central gray substance of midbrain
14:
9535:
7133:
6466:"Untangling tau-related dementia"
6304:Baudier J, Cole RD (April 1988).
3247:"Lessons from tau-deficient mice"
2508:Prion-like propagation hypothesis
1927:intrinsically disordered proteins
1226:supramolecular fiber organization
1211:regulation of synaptic plasticity
1041:axonal transport of mitochondrion
779:protein homodimerization activity
7832:Wiskott–Aldrich syndrome protein
6992:10.1111/j.1750-3639.2007.00052.x
6883:10.1111/j.1445-5994.2006.01153.x
6804:Biochemical Society Transactions
6435:(3): 365–71, discussion 371–80.
5774:(1): 128–34, discussion 128–34.
5108:Hall GF, Patuto BA (July 2012).
4148:Biochemical Society Transactions
2606:Aging-related tau astrogliopathy
2502:chronic traumatic encephalopathy
2492:(TBI) is a central component of
2450:, which can lead to cell death.
2329:) that cause disease-associated
630:
623:
616:
378:
371:
365:
342:
277:
270:
264:
239:
9053:Microtubule organising proteins
6255:Yu WH, Fraser PE (April 2001).
6074:
6033:
5964:
5950:Strait JS (December 13, 2011).
5851:
5802:
5759:
5741:
5692:
5641:
5608:
5585:
5534:
5491:
5432:
5330:
5287:
5244:
5201:
5150:
4936:
4887:
4838:
4789:
4738:
4697:
4646:
4605:
4561:
4510:
4451:
4392:
3964:
3928:
3877:
3838:
3789:
3738:
3645:
3606:
3557:
3498:
3389:
3338:
3289:
3238:
3216:10.1016/j.pneurobio.2008.03.002
3043:
2535:
1976:microtubule-associated proteins
1131:neurofibrillary tangle assembly
1091:protein complex oligomerization
5815:Science Translational Medicine
3851:Journal of Alzheimer's Disease
3474:10.1523/JNEUROSCI.3029-15.2016
3114:10.1523/JNEUROSCI.0391-19.2019
2890:
2707:
2689:
2615:Progressive supranuclear palsy
2540:Tau protein has been shown to
2446:functions and interferes with
2046:and altered synaptic function.
1868:microtubule-associated protein
890:microtubule associated complex
729:protein phosphatase 2A binding
641:More reference expression data
596:More reference expression data
496:right hemisphere of cerebellum
1:
9100:Microtubule severing proteins
6616:10.1016/S1471-4914(02)02440-1
6528:10.1016/S0925-4439(00)00037-5
6323:10.1016/S0021-9258(18)60647-7
5308:10.1016/s0166-2236(00)02031-2
5265:10.1016/S0531-5565(00)00114-5
4864:10.1016/S0092-8674(04)00170-9
4710:Annual Review of Neuroscience
4333:10.1016/S0021-9258(18)47378-4
3716:10.1016/s0304-3940(99)00964-7
3345:Dehmelt L, Halpain S (2004).
2641:
2602:Primary age-related tauopathy
2287:heparan sulfate proteoglycans
1051:neuron projection development
794:histone-dependent DNA binding
784:sequence-specific DNA binding
363:
262:
9519:Genes on human chromosome 17
7760:actin depolymerizing factors
6777:10.1016/j.molmed.2005.02.008
6765:Trends in Molecular Medicine
6604:Trends in Molecular Medicine
6441:10.1016/0197-4580(95)00027-C
6404:10.1016/0166-2236(91)90105-4
6059:10.1001/jamaneurol.2013.5847
5981:10.1007/978-981-32-9358-8_23
5827:10.1126/scitranslmed.3003716
5512:10.1016/0006-8993(90)90765-4
5163:Indian Journal of Psychiatry
4957:10.1016/j.molmed.2005.02.008
4945:Trends in Molecular Medicine
4618:Journal of Molecular Biology
4590:10.1016/j.celrep.2015.04.043
4370:10.1016/0896-6273(94)90264-X
3990:10.1016/j.bbadis.2004.06.020
3950:10.1016/0169-328x(86)90033-1
3670:10.1097/WNR.0b013e32818b2a0b
3064:10.1016/0022-2836(77)90214-5
3052:Journal of Molecular Biology
3029:10.1016/0022-2836(77)90213-3
3017:Journal of Molecular Biology
2989:10.1016/j.biocel.2010.07.016
2868:10.1016/0896-6273(89)90210-9
2462:activity and is, along with
2271:
2201:
1921:insoluble aggregates called
769:phosphatidylinositol binding
694:lipoprotein particle binding
7:
9238:Plakoglobin (gamma catenin)
7095:The Journal of Cell Biology
6846:10.1016/j.pnpbp.2006.04.007
6261:The Journal of Neuroscience
6212:The Journal of Neuroscience
5541:Kovács KA (December 2021).
3462:The Journal of Neuroscience
3102:The Journal of Neuroscience
2578:
2312:
2146:
2060:
1985:Although tau is present in
1957:
910:somatodendritic compartment
799:microtubule lateral binding
749:single-stranded DNA binding
744:double-stranded DNA binding
582:nucleus of stria terminalis
10:
9540:
6100:10.1248/yakushi.18-00165-6
3582:10.1007/s00401-019-01970-9
3524:10.1186/s40478-021-01208-4
3315:10.1016/j.cell.2010.06.036
2916:10.1186/s13041-022-00935-6
2384:neurodegenerative diseases
2358:, pTau) can result in the
2344:
2280:
1784:Chr 11: 104.23 – 104.33 Mb
1206:microtubule polymerization
1016:microglial cell activation
9494:
9451:
9350:
9256:
9211:
9120:
9099:
9051:
8874:
8666:
8618:
8470:
8456:
8422:
8369:
8338:
8318:
8197:
8079:
7910:
7892:
7881:
7824:
7617:
7296:
7253:
7244:
7230:
7223:
7043:10.1016/j.nbd.2007.04.006
6951:10.1517/14728222.11.4.435
6871:Internal Medicine Journal
5077:10.1007/s12035-016-0299-z
4751:Frontiers in Neuroscience
4672:10.1186/s40478-019-0682-x
4631:10.1016/j.jmb.2018.12.008
4273:Journal of Neurochemistry
3903:10.1186/s40478-017-0489-6
2715:"Mouse PubMed Reference:"
2697:"Human PubMed Reference:"
2610:Corticobasal degeneration
1963:Microtubule stabilization
1822:
1817:
1813:
1806:
1790:
1771:
1652:
1628:
1587:
1563:
1556:
1525:
1521:
1480:
1456:
1449:
1436:
1432:
1417:
1413:
1404:
1391:
1387:
1364:
1360:
1351:
1338:
1334:
1319:
1315:
1306:
1291:
1284:
1280:
1264:
1066:cellular response to heat
774:identical protein binding
659:
655:
638:
615:
606:
593:
542:
533:
508:anterior cingulate cortex
480:
471:
441:
433:
429:
412:
399:
362:
341:
332:
328:
311:
298:
261:
238:
229:
225:
180:
177:
167:
160:
155:
68:
63:
46:
41:
36:
32:
28:
23:
9464:Prokaryotic cytoskeleton
7144:Medical Subject Headings
6912:Human Molecular Genetics
6470:Human Molecular Genetics
6464:Heutink P (April 2000).
6141:10.1074/jbc.274.36.25481
5615:Belluck P (2020-07-28).
5253:Experimental Gerontology
4900:Human Molecular Genetics
4764:10.3389/fnins.2017.00667
3414:10.15252/embj.2018101174
3204:Progress in Neurobiology
2422:(PHFs) in the AD brain.
2420:paired helical filaments
2354:of the tau protein (tau
1878:and are abundant in the
1777:Chr 17: 45.89 – 46.03 Mb
1246:amyloid fibril formation
940:microtubule cytoskeleton
724:receptor ligand activity
7155:MR scans of variant CJD
7031:Neurobiology of Disease
6392:Trends in Neurosciences
6165:Neuromolecular Medicine
6040:Bloom GS (April 2014).
5717:10.1001/jama.2020.12134
5466:10.1073/pnas.90.14.6825
5407:10.1074/jbc.M114.611368
5296:Trends in Neurosciences
5176:10.4103/0019-5545.44908
4426:10.1073/pnas.0400348101
4187:The Biochemical Journal
3863:10.3233/JAD-2010-100285
3767:10.1126/science.1141736
3619:Journal of Cell Science
3364:10.1186/gb-2004-6-1-204
2821:10.1073/pnas.85.11.4051
2522:frontotemporal dementia
2416:neurofibrillary tangles
2376:frontotemporal dementia
2335:neurofibrillary tangles
2240:serine/threonine kinase
1951:EnCor Biotechnology Inc
1923:neurofibrillary tangles
1196:stress granule assembly
991:regulation of autophagy
7107:10.1083/jcb.107.4.1449
7070:Folia Neuropathologica
6707:Folia Neuropathologica
6567:Molecular Neurobiology
6364:10.1074/jbc.M003738200
5065:Molecular Neurobiology
5015:10.1073/pnas.121119298
4536:10.1074/jbc.M808759200
4249:10.1074/jbc.M007427200
3631:10.1242/jcs.114.6.1179
2762:10.1073/pnas.72.5.1858
2490:traumatic brain injury
2484:Traumatic brain injury
2430:action or exposure to
1954:
1884:central nervous system
1176:rRNA metabolic process
845:neurofibrillary tangle
759:protein kinase binding
674:apolipoprotein binding
550:lateral septal nucleus
484:superior frontal gyrus
396:11 67.79 cM|11 E1
8084:(hard alpha-keratins)
7915:(soft alpha-keratins)
6579:10.1385/MN:24:1-3:087
6429:Neurobiology of Aging
5755:. PBS Online by WGBH.
5222:10.1007/s004010100423
5210:Acta Neuropathologica
4485:10.1073/pnas.94.1.298
3570:Acta Neuropathologica
2345:Further information:
2341:Clinical significance
2169:alternatively spliced
1974:Other nervous system
1935:
986:generation of neurons
970:glial cell projection
734:Hsp90 protein binding
504:primary visual cortex
357:Chromosome 11 (mouse)
255:Chromosome 17 (human)
9499:cytoskeletal defects
9459:Major sperm proteins
7157:CSF tau-positive man
6177:10.1385/NMM:4:1-2:49
5925:10.1093/brain/awr286
5876:10.1093/brain/aws307
5667:10.1084/jem.20200861
5560:10.3390/ijms23010462
5356:10.3390/cells8030260
3704:Neuroscience Letters
2592:Dementia pugilistica
2460:alkaline phosphatase
2352:Hyperphosphorylation
2109:neuronal development
1857:alternative splicing
1161:response to lead ion
1081:synapse organization
1071:astrocyte activation
925:extracellular region
570:lateral hypothalamus
546:ventromedial nucleus
64:List of PDB id codes
37:Available structures
7912:Epithelial keratins
6483:10.1093/hmg/9.6.979
5597:The Free Dictionary
5457:1993PNAS...90.6825S
5006:2001PNAS...98.6923A
4802:Nature Neuroscience
4476:1997PNAS...94..298A
4417:2004PNAS..10110804L
4411:(29): 10804–10809.
4124:10.1038/hdy.2008.70
3759:2007Sci...316..750R
3264:10.1155/2012/873270
3162:1994Natur.369..488H
2812:1988PNAS...85.4051G
2753:1975PNAS...72.1858W
2597:Alzheimer's disease
2518:Alzheimer's disease
2471:hyperphosphorylated
2372:Alzheimer's disease
2105:cellular signalling
1919:hyperphosphorylated
1915:Parkinson's disease
1911:Alzheimer's disease
1156:cell-cell signaling
1026:signal transduction
714:microtubule binding
6921:10.1093/hmg/ddl190
6816:10.1042/BST0330582
6740:10.1002/humu.20086
5621:The New York Times
4912:10.1093/hmg/ddn326
4160:10.1042/BST0330582
3257:(873270): 873270.
2436:glycosaminoglycans
2219:with 79 potential
2159:21, containing 16
2069:and to facilitate
2051:ribosomal proteins
2014:signaling proteins
1955:
1942:immunofluorescence
1839:(abbreviated from
1394:ENSMUSG00000018411
979:Biological process
915:neuronal cell body
813:Cellular component
679:SH3 domain binding
667:Molecular function
516:hippocampus proper
492:right frontal lobe
9506:
9505:
9447:
9446:
9207:
9206:
8452:
8451:
8334:
8333:
7877:
7876:
7820:
7819:
6682:10.1159/000077150
6645:10.1159/000077149
5990:978-981-329-357-1
5919:(Pt 4): 1268–80.
5400:(49): 34389–407.
5126:10.4161/pri.19912
5071:(10): 7979–7993.
4745:Yamada K (2017).
4199:10.1042/bj3230577
3625:(Pt 6): 1179–87.
3108:(42): 8315–8329.
2498:American football
2299:entorhinal cortex
2078:fear conditioning
2044:protein synthesis
1886:(CNS), where the
1833:
1832:
1829:
1828:
1802:
1801:
1767:
1766:
1622:
1621:
1552:
1551:
1515:
1514:
1445:
1444:
1426:
1425:
1400:
1399:
1381:
1380:
1347:
1346:
1328:
1327:
1276:
1275:
950:neuron projection
835:nuclear periphery
789:chaperone binding
651:
650:
647:
646:
602:
601:
589:
588:
578:entorhinal cortex
558:perirhinal cortex
527:
526:
488:prefrontal cortex
425:
424:
324:
323:
151:
150:
147:
146:
47:Ortholog search:
9531:
8468:
8467:
7908:
7907:
7890:
7889:
7251:
7250:
7242:
7241:
7228:
7227:
7206:
7199:
7192:
7183:
7182:
7128:
7118:
7085:
7064:
7054:
7021:
7003:
6970:
6933:
6923:
6902:
6865:
6827:
6798:
6788:
6759:
6722:
6701:
6664:
6627:
6598:
6561:
6552:(11): 1297–307.
6540:
6530:
6505:
6495:
6485:
6460:
6423:
6377:
6376:
6366:
6357:(33): 25247–54.
6342:
6336:
6335:
6325:
6301:
6295:
6294:
6284:
6252:
6246:
6245:
6235:
6203:
6197:
6196:
6160:
6154:
6153:
6143:
6119:
6113:
6112:
6102:
6093:(7): 1021–1025.
6078:
6072:
6071:
6061:
6037:
6031:
6030:
6024:
6020:
6018:
6010:
5968:
5962:
5959:
5946:
5936:
5904:
5898:
5897:
5887:
5855:
5849:
5848:
5838:
5821:(134): 134ra60.
5806:
5800:
5799:
5763:
5757:
5756:
5745:
5739:
5738:
5728:
5696:
5690:
5689:
5679:
5669:
5645:
5639:
5638:
5636:
5635:
5612:
5606:
5605:
5604:
5603:
5589:
5583:
5582:
5572:
5562:
5538:
5532:
5531:
5495:
5489:
5488:
5478:
5468:
5436:
5430:
5429:
5419:
5409:
5385:
5379:
5378:
5368:
5358:
5334:
5328:
5327:
5291:
5285:
5284:
5248:
5242:
5241:
5205:
5199:
5198:
5188:
5178:
5154:
5148:
5147:
5137:
5105:
5099:
5098:
5088:
5056:
5050:
5047:
5038:
5037:
5027:
5017:
4985:
4979:
4978:
4968:
4940:
4934:
4933:
4923:
4891:
4885:
4884:
4866:
4842:
4836:
4835:
4825:
4793:
4787:
4786:
4776:
4766:
4742:
4736:
4735:
4725:
4701:
4695:
4694:
4684:
4674:
4650:
4644:
4643:
4633:
4609:
4603:
4602:
4592:
4574:
4565:
4559:
4558:
4548:
4538:
4529:(19): 12845–52.
4514:
4508:
4507:
4497:
4487:
4455:
4449:
4448:
4438:
4428:
4396:
4390:
4389:
4352:
4346:
4345:
4335:
4311:
4305:
4304:
4268:
4262:
4261:
4251:
4242:(13): 10025–31.
4227:
4221:
4220:
4210:
4178:
4172:
4171:
4143:
4137:
4136:
4126:
4102:
4096:
4095:
4085:
4053:
4047:
4046:
4009:
4003:
4002:
3992:
3968:
3962:
3961:
3932:
3926:
3925:
3915:
3905:
3881:
3875:
3874:
3842:
3836:
3835:
3825:
3793:
3787:
3786:
3742:
3736:
3735:
3699:
3690:
3689:
3649:
3643:
3642:
3610:
3604:
3603:
3593:
3561:
3555:
3554:
3544:
3526:
3502:
3496:
3495:
3485:
3453:
3444:
3443:
3433:
3402:The EMBO Journal
3393:
3387:
3386:
3376:
3366:
3342:
3336:
3335:
3317:
3293:
3287:
3286:
3276:
3266:
3242:
3236:
3235:
3199:
3190:
3189:
3170:10.1038/369488a0
3156:(6480): 488–91.
3145:
3136:
3135:
3125:
3093:
3076:
3075:
3047:
3041:
3040:
3012:
3001:
3000:
2972:
2966:
2965:
2945:
2939:
2938:
2928:
2918:
2894:
2888:
2887:
2850:
2844:
2843:
2833:
2823:
2791:
2785:
2784:
2774:
2764:
2732:
2723:
2722:
2711:
2705:
2704:
2693:
2687:
2677:
2666:
2656:
2488:Repetitive mild
2448:axonal transport
2291:macropinocytosis
2212:carboxy-terminus
2089:sleep-wake cycle
2067:long-term memory
2024:mRNA translation
2016:and to regulate
1901:Pathologies and
1896:oligodendrocytes
1853:protein isoforms
1815:
1814:
1786:
1779:
1762:
1626:
1625:
1617:
1561:
1560:
1557:RefSeq (protein)
1547:
1519:
1518:
1510:
1454:
1453:
1430:
1429:
1411:
1410:
1385:
1384:
1358:
1357:
1332:
1331:
1313:
1312:
1282:
1281:
1216:axon development
1111:axonal transport
719:dynactin binding
657:
656:
643:
634:
627:
620:
613:
612:
598:
538:
536:Top expressed in
531:
530:
476:
474:Top expressed in
469:
468:
448:
447:
431:
430:
421:
408:
397:
382:
375:
369:
358:
346:
330:
329:
320:
307:
296:
281:
274:
268:
257:
243:
227:
226:
221:
219:MAPT - orthologs
172:
165:
142:
61:
60:
55:
34:
33:
21:
20:
9539:
9538:
9534:
9533:
9532:
9530:
9529:
9528:
9509:
9508:
9507:
9502:
9490:
9443:
9346:
9252:
9203:
9116:
9095:
9047:
8870:
8662:
8614:
8460:
8448:
8418:
8365:
8330:
8314:
8198:Ungrouped alpha
8193:
8083:
8075:
7914:
7900:
7894:
7884:
7873:
7816:
7613:
7292:
7234:
7219:
7210:
7136:
7131:
6980:Brain Pathology
6810:(Pt 4): 582–5.
6385:
6383:Further reading
6380:
6343:
6339:
6316:(12): 5876–83.
6302:
6298:
6253:
6249:
6204:
6200:
6161:
6157:
6134:(36): 25481–9.
6120:
6116:
6087:Yakugaku Zasshi
6079:
6075:
6038:
6034:
6022:
6021:
6012:
6011:
5991:
5969:
5965:
5905:
5901:
5870:(Pt 1): 43–64.
5856:
5852:
5807:
5803:
5764:
5760:
5747:
5746:
5742:
5697:
5693:
5646:
5642:
5633:
5631:
5613:
5609:
5601:
5599:
5591:
5590:
5586:
5539:
5535:
5506:(1–2): 127–35.
5496:
5492:
5437:
5433:
5386:
5382:
5335:
5331:
5292:
5288:
5249:
5245:
5206:
5202:
5155:
5151:
5106:
5102:
5057:
5053:
5048:
5041:
4986:
4982:
4941:
4937:
4892:
4888:
4843:
4839:
4814:10.1038/nn.4132
4808:(11): 1584–93.
4794:
4790:
4743:
4739:
4702:
4698:
4651:
4647:
4610:
4606:
4572:
4566:
4562:
4515:
4511:
4456:
4452:
4397:
4393:
4364:(4): 989–1002.
4353:
4349:
4326:(49): 30981–7.
4312:
4308:
4269:
4265:
4228:
4224:
4179:
4175:
4154:(Pt 4): 582–5.
4144:
4140:
4103:
4099:
4062:Nature Genetics
4054:
4050:
4015:Nature Genetics
4010:
4006:
3983:(2–3): 179–97.
3969:
3965:
3933:
3929:
3882:
3878:
3843:
3839:
3794:
3790:
3753:(5825): 750–4.
3743:
3739:
3700:
3693:
3664:(10): 1049–52.
3650:
3646:
3611:
3607:
3562:
3558:
3503:
3499:
3454:
3447:
3408:(13): e101174.
3394:
3390:
3343:
3339:
3294:
3290:
3243:
3239:
3200:
3193:
3146:
3139:
3094:
3079:
3048:
3044:
3013:
3004:
2973:
2969:
2946:
2942:
2903:Molecular Brain
2895:
2891:
2851:
2847:
2792:
2788:
2733:
2726:
2713:
2712:
2708:
2695:
2694:
2690:
2678:
2669:
2657:
2648:
2644:
2639:
2581:
2549:Alpha-synuclein
2538:
2510:
2486:
2408:
2349:
2343:
2331:phosphoepitopes
2315:
2283:
2274:
2256:dephosphorylate
2204:
2177:N-terminal part
2151:In humans, the
2149:
2113:neuroprotection
2101:
2099:Other functions
2063:
2026:
2007:phosphorylation
1965:
1960:
1888:cerebral cortex
1824:View/Edit Mouse
1819:View/Edit Human
1782:
1775:
1772:Location (UCSC)
1758:
1754:
1750:
1746:
1742:
1738:
1734:
1730:
1726:
1722:
1718:
1714:
1710:
1706:
1702:
1698:
1694:
1690:
1686:
1682:
1678:
1674:
1670:
1666:
1662:
1658:
1654:
1648:
1644:
1640:
1636:
1632:
1613:
1609:
1605:
1601:
1597:
1593:
1589:
1583:
1579:
1575:
1571:
1567:
1543:
1539:
1535:
1531:
1527:
1506:
1502:
1498:
1494:
1490:
1486:
1482:
1476:
1472:
1468:
1464:
1460:
1375:ENSG00000277956
1373:
1371:ENSG00000276155
1369:
1367:ENSG00000186868
1260:
974:
955:dendritic spine
855:tubulin complex
850:plasma membrane
830:cell projection
808:
689:protein binding
684:tubulin binding
639:
629:
628:
622:
621:
594:
585:
580:
576:
572:
568:
564:
562:mammillary body
560:
556:
552:
548:
534:
523:
518:
514:
510:
506:
502:
500:Brodmann area 9
498:
494:
490:
486:
472:
416:
403:
395:
385:
384:
383:
376:
356:
333:Gene location (
315:
302:
294:
284:
283:
282:
275:
253:
230:Gene location (
181:
168:
161:
70:
48:
17:
12:
11:
5:
9537:
9527:
9526:
9521:
9504:
9503:
9495:
9492:
9491:
9489:
9488:
9487:
9486:
9481:
9476:
9471:
9461:
9455:
9453:
9449:
9448:
9445:
9444:
9442:
9441:
9436:
9431:
9430:
9429:
9424:
9414:
9409:
9408:
9407:
9397:
9396:
9395:
9390:
9385:
9380:
9375:
9370:
9365:
9363:Corneodesmosin
9354:
9352:
9348:
9347:
9345:
9344:
9343:
9342:
9337:
9332:
9327:
9322:
9317:
9312:
9302:
9301:
9300:
9295:
9290:
9280:
9275:
9274:
9273:
9262:
9260:
9254:
9253:
9251:
9250:
9245:
9240:
9235:
9234:
9233:
9223:
9217:
9215:
9209:
9208:
9205:
9204:
9202:
9201:
9200:
9199:
9194:
9189:
9179:
9178:
9177:
9172:
9167:
9162:
9157:
9147:
9142:
9141:
9140:
9130:
9124:
9122:
9118:
9117:
9115:
9114:
9109:
9103:
9101:
9097:
9096:
9094:
9093:
9088:
9083:
9078:
9073:
9068:
9063:
9057:
9055:
9049:
9048:
9046:
9045:
9040:
9035:
9030:
9025:
9020:
9015:
9010:
9005:
9000:
8995:
8990:
8985:
8978:
8977:
8972:
8967:
8962:
8957:
8952:
8947:
8942:
8937:
8932:
8927:
8922:
8917:
8912:
8907:
8902:
8897:
8892:
8887:
8880:
8878:
8872:
8871:
8869:
8868:
8863:
8858:
8853:
8848:
8843:
8838:
8833:
8828:
8823:
8818:
8813:
8808:
8803:
8798:
8793:
8788:
8783:
8778:
8773:
8768:
8763:
8758:
8753:
8748:
8743:
8738:
8733:
8728:
8723:
8718:
8713:
8708:
8703:
8698:
8693:
8688:
8683:
8678:
8672:
8670:
8664:
8663:
8661:
8660:
8655:
8650:
8645:
8640:
8635:
8630:
8624:
8622:
8616:
8615:
8613:
8612:
8607:
8602:
8597:
8592:
8587:
8582:
8577:
8572:
8567:
8562:
8557:
8552:
8547:
8542:
8537:
8532:
8527:
8522:
8517:
8512:
8507:
8502:
8497:
8492:
8487:
8482:
8476:
8474:
8465:
8454:
8453:
8450:
8449:
8447:
8446:
8441:
8436:
8430:Nuclear lamins
8426:
8424:
8420:
8419:
8417:
8416:
8411:
8406:
8405:
8404:
8399:
8394:
8384:
8379:
8373:
8371:
8367:
8366:
8364:
8363:
8358:
8353:
8348:
8342:
8340:
8336:
8335:
8332:
8331:
8329:
8328:
8322:
8320:
8316:
8315:
8313:
8312:
8311:
8310:
8305:
8300:
8295:
8290:
8285:
8280:
8275:
8270:
8265:
8252:
8251:
8250:
8249:
8244:
8239:
8234:
8229:
8224:
8219:
8214:
8201:
8199:
8195:
8194:
8192:
8191:
8190:
8189:
8184:
8179:
8174:
8169:
8164:
8147:
8146:
8145:
8144:
8139:
8134:
8129:
8124:
8119:
8114:
8109:
8104:
8087:
8085:
8077:
8076:
8074:
8073:
8072:
8071:
8066:
8061:
8056:
8051:
8046:
8041:
8036:
8031:
8026:
8009:
8008:
8007:
8006:
7996:
7995:
7994:
7982:
7981:
7980:
7975:
7970:
7965:
7960:
7955:
7950:
7945:
7940:
7935:
7918:
7916:
7905:
7887:
7879:
7878:
7875:
7874:
7872:
7871:
7866:
7861:
7860:
7859:
7854:
7849:
7839:
7834:
7828:
7826:
7822:
7821:
7818:
7817:
7815:
7814:
7809:
7808:
7807:
7802:
7792:
7787:
7786:
7785:
7780:
7779:
7778:
7773:
7756:
7754:Arp2/3 complex
7751:
7750:
7749:
7744:
7739:
7734:
7723:
7722:
7721:
7720:
7715:
7710:
7705:
7695:
7694:
7693:
7679:
7668:
7649:
7648:
7647:
7642:
7637:
7632:
7621:
7619:
7615:
7614:
7612:
7611:
7610:
7609:
7604:
7599:
7594:
7589:
7584:
7579:
7574:
7569:
7564:
7559:
7554:
7549:
7539:
7538:
7537:
7532:
7524:
7523:
7522:
7514:
7513:
7512:
7504:
7503:
7502:
7497:
7489:
7488:
7487:
7482:
7474:
7473:
7472:
7464:
7463:
7462:
7457:
7452:
7444:
7443:
7442:
7437:
7429:
7428:
7427:
7422:
7417:
7412:
7407:
7402:
7397:
7392:
7387:
7382:
7377:
7372:
7367:
7362:
7357:
7349:
7348:
7347:
7341:
7336:
7331:
7326:
7321:
7316:
7311:
7302:
7300:
7294:
7293:
7291:
7290:
7285:
7280:
7275:
7270:
7265:
7259:
7257:
7248:
7239:
7232:Microfilaments
7225:
7221:
7220:
7209:
7208:
7201:
7194:
7186:
7180:
7179:
7158:
7152:
7147:
7135:
7134:External links
7132:
7130:
7129:
7101:(4): 1449–59.
7086:
7065:
7022:
6971:
6934:
6903:
6877:(10): 652–60.
6866:
6840:(8): 1369–80.
6828:
6799:
6760:
6728:Human Mutation
6723:
6702:
6665:
6628:
6610:(12): 555–62.
6599:
6573:(1–3): 87–97.
6562:
6541:
6506:
6461:
6424:
6386:
6384:
6381:
6379:
6378:
6337:
6296:
6247:
6218:(3): 698–707.
6198:
6171:(1–2): 49–58.
6155:
6114:
6073:
6052:(4): 505–508.
6046:JAMA Neurology
6032:
6023:|journal=
5989:
5963:
5961:
5960:
5899:
5850:
5801:
5758:
5749:"Brain Trauma"
5740:
5711:(8): 772–781.
5691:
5640:
5607:
5584:
5533:
5500:Brain Research
5490:
5451:(14): 6825–8.
5431:
5380:
5329:
5286:
5243:
5200:
5149:
5100:
5051:
5039:
5000:(12): 6923–8.
4980:
4935:
4886:
4837:
4788:
4737:
4716:(1): 189–210.
4696:
4645:
4624:(4): 687–695.
4604:
4583:(8): 1176–83.
4560:
4509:
4470:(1): 298–303.
4450:
4391:
4347:
4306:
4279:(5): 1667–75.
4263:
4222:
4173:
4138:
4097:
4074:10.1038/ng.193
4068:(9): 1076–83.
4048:
4027:10.1038/ng1858
4004:
3963:
3938:Brain Research
3927:
3876:
3837:
3788:
3737:
3691:
3644:
3605:
3576:(4): 571–583.
3556:
3497:
3445:
3388:
3351:Genome Biology
3337:
3288:
3237:
3191:
3137:
3077:
3042:
3002:
2983:(11): 1775–8.
2967:
2956:(5): 693–702.
2940:
2889:
2845:
2806:(11): 4051–5.
2786:
2747:(5): 1858–62.
2724:
2706:
2688:
2667:
2645:
2643:
2640:
2638:
2637:
2632:
2627:
2625:Pick's disease
2622:
2617:
2612:
2607:
2604:
2599:
2594:
2589:
2582:
2580:
2577:
2576:
2575:
2569:
2563:
2558:
2552:
2537:
2534:
2509:
2506:
2494:contact sports
2485:
2482:
2412:tau hypothesis
2407:
2404:
2342:
2339:
2314:
2311:
2282:
2279:
2273:
2270:
2217:phosphoprotein
2203:
2200:
2157:chromosome 17q
2148:
2145:
2137:chronic stress
2100:
2097:
2062:
2059:
2025:
2022:
1964:
1961:
1959:
1956:
1907:nervous system
1831:
1830:
1827:
1826:
1821:
1811:
1810:
1804:
1803:
1800:
1799:
1797:
1795:
1788:
1787:
1780:
1773:
1769:
1768:
1765:
1764:
1650:
1649:
1623:
1620:
1619:
1585:
1584:
1558:
1554:
1553:
1550:
1549:
1523:
1522:
1516:
1513:
1512:
1478:
1477:
1451:
1447:
1446:
1443:
1442:
1434:
1433:
1427:
1424:
1423:
1415:
1414:
1408:
1402:
1401:
1398:
1397:
1389:
1388:
1382:
1379:
1378:
1362:
1361:
1355:
1349:
1348:
1345:
1344:
1336:
1335:
1329:
1326:
1325:
1317:
1316:
1310:
1304:
1303:
1298:
1293:
1289:
1288:
1278:
1277:
1274:
1273:
1262:
1261:
1259:
1258:
1253:
1248:
1243:
1238:
1233:
1228:
1223:
1218:
1213:
1208:
1203:
1198:
1193:
1188:
1183:
1178:
1173:
1168:
1163:
1158:
1153:
1148:
1143:
1138:
1133:
1128:
1123:
1118:
1113:
1108:
1103:
1098:
1093:
1088:
1083:
1078:
1073:
1068:
1063:
1058:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1018:
1013:
1008:
1003:
998:
993:
988:
982:
980:
976:
975:
973:
972:
967:
962:
957:
952:
947:
942:
937:
932:
927:
922:
920:axon cytoplasm
917:
912:
907:
902:
897:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
816:
814:
810:
809:
807:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
699:enzyme binding
696:
691:
686:
681:
676:
670:
668:
664:
663:
653:
652:
649:
648:
645:
644:
636:
635:
610:
604:
603:
600:
599:
591:
590:
587:
586:
584:
583:
579:
575:
571:
567:
563:
559:
555:
551:
547:
543:
540:
539:
528:
525:
524:
522:
521:
517:
513:
509:
505:
501:
497:
493:
489:
485:
481:
478:
477:
465:
464:
456:
445:
439:
438:
435:RNA expression
427:
426:
423:
422:
414:
410:
409:
401:
398:
393:
387:
386:
377:
370:
364:
360:
359:
354:
348:
347:
339:
338:
326:
325:
322:
321:
313:
309:
308:
300:
297:
292:
286:
285:
276:
269:
263:
259:
258:
251:
245:
244:
236:
235:
223:
222:
179:
175:
174:
166:
158:
157:
153:
152:
149:
148:
145:
144:
66:
65:
57:
56:
45:
39:
38:
30:
29:
26:
25:
15:
9:
6:
4:
3:
2:
9536:
9525:
9522:
9520:
9517:
9516:
9514:
9501:
9500:
9493:
9485:
9482:
9480:
9477:
9475:
9472:
9470:
9467:
9466:
9465:
9462:
9460:
9457:
9456:
9454:
9450:
9440:
9437:
9435:
9432:
9428:
9425:
9423:
9420:
9419:
9418:
9415:
9413:
9410:
9406:
9403:
9402:
9401:
9398:
9394:
9391:
9389:
9386:
9384:
9381:
9379:
9376:
9374:
9371:
9369:
9366:
9364:
9361:
9360:
9359:
9356:
9355:
9353:
9349:
9341:
9338:
9336:
9333:
9331:
9328:
9326:
9323:
9321:
9318:
9316:
9313:
9311:
9308:
9307:
9306:
9303:
9299:
9296:
9294:
9291:
9289:
9286:
9285:
9284:
9281:
9279:
9276:
9272:
9269:
9268:
9267:
9264:
9263:
9261:
9259:
9255:
9249:
9246:
9244:
9243:Delta catenin
9241:
9239:
9236:
9232:
9229:
9228:
9227:
9224:
9222:
9221:Alpha catenin
9219:
9218:
9216:
9214:
9210:
9198:
9195:
9193:
9190:
9188:
9185:
9184:
9183:
9180:
9176:
9173:
9171:
9168:
9166:
9163:
9161:
9158:
9156:
9153:
9152:
9151:
9148:
9146:
9143:
9139:
9136:
9135:
9134:
9131:
9129:
9126:
9125:
9123:
9119:
9113:
9110:
9108:
9105:
9104:
9102:
9098:
9092:
9089:
9087:
9084:
9082:
9079:
9077:
9074:
9072:
9069:
9067:
9064:
9062:
9059:
9058:
9056:
9054:
9050:
9044:
9041:
9039:
9036:
9034:
9031:
9029:
9026:
9024:
9021:
9019:
9016:
9014:
9011:
9009:
9006:
9004:
9001:
8999:
8996:
8994:
8991:
8989:
8986:
8984:
8981:cytoplasmic:
8980:
8979:
8976:
8973:
8971:
8968:
8966:
8963:
8961:
8958:
8956:
8953:
8951:
8948:
8946:
8943:
8941:
8938:
8936:
8933:
8931:
8928:
8926:
8923:
8921:
8918:
8916:
8913:
8911:
8908:
8906:
8903:
8901:
8898:
8896:
8893:
8891:
8888:
8886:
8882:
8881:
8879:
8877:
8873:
8867:
8864:
8862:
8859:
8857:
8854:
8852:
8849:
8847:
8844:
8842:
8839:
8837:
8834:
8832:
8829:
8827:
8824:
8822:
8819:
8817:
8814:
8812:
8809:
8807:
8804:
8802:
8799:
8797:
8794:
8792:
8789:
8787:
8784:
8782:
8779:
8777:
8774:
8772:
8769:
8767:
8764:
8762:
8759:
8757:
8754:
8752:
8749:
8747:
8744:
8742:
8739:
8737:
8734:
8732:
8729:
8727:
8724:
8722:
8719:
8717:
8714:
8712:
8709:
8707:
8704:
8702:
8699:
8697:
8694:
8692:
8689:
8687:
8684:
8682:
8679:
8677:
8674:
8673:
8671:
8669:
8665:
8659:
8656:
8654:
8651:
8649:
8646:
8644:
8641:
8639:
8636:
8634:
8631:
8629:
8626:
8625:
8623:
8621:
8617:
8611:
8608:
8606:
8603:
8601:
8598:
8596:
8593:
8591:
8588:
8586:
8583:
8581:
8578:
8576:
8573:
8571:
8568:
8566:
8563:
8561:
8558:
8556:
8553:
8551:
8548:
8546:
8543:
8541:
8538:
8536:
8533:
8531:
8528:
8526:
8523:
8521:
8518:
8516:
8513:
8511:
8508:
8506:
8503:
8501:
8498:
8496:
8493:
8491:
8488:
8486:
8483:
8481:
8478:
8477:
8475:
8473:
8469:
8466:
8464:
8459:
8455:
8445:
8442:
8440:
8437:
8435:
8431:
8428:
8427:
8425:
8421:
8415:
8412:
8410:
8407:
8403:
8400:
8398:
8395:
8393:
8390:
8389:
8388:
8387:Neurofilament
8385:
8383:
8380:
8378:
8375:
8374:
8372:
8368:
8362:
8359:
8357:
8354:
8352:
8349:
8347:
8344:
8343:
8341:
8337:
8327:
8324:
8323:
8321:
8317:
8309:
8306:
8304:
8301:
8299:
8296:
8294:
8291:
8289:
8286:
8284:
8281:
8279:
8276:
8274:
8271:
8269:
8266:
8264:
8261:
8260:
8259:
8258:
8257:chromosome 12
8254:
8253:
8248:
8245:
8243:
8240:
8238:
8235:
8233:
8230:
8228:
8225:
8223:
8220:
8218:
8215:
8213:
8210:
8209:
8208:
8207:
8206:chromosome 17
8203:
8202:
8200:
8196:
8188:
8185:
8183:
8180:
8178:
8175:
8173:
8170:
8168:
8165:
8163:
8160:
8159:
8158:
8157:
8156:chromosome 12
8153:
8149:
8148:
8143:
8140:
8138:
8135:
8133:
8130:
8128:
8125:
8123:
8120:
8118:
8115:
8113:
8110:
8108:
8105:
8103:
8100:
8099:
8098:
8097:
8096:chromosome 17
8093:
8089:
8088:
8086:
8082:
8081:Hair keratins
8078:
8070:
8067:
8065:
8062:
8060:
8057:
8055:
8052:
8050:
8047:
8045:
8042:
8040:
8037:
8035:
8032:
8030:
8027:
8025:
8022:
8021:
8020:
8019:
8018:chromosome 12
8015:
8011:
8010:
8005:
8002:
8001:
8000:
7997:
7993:
7990:
7989:
7988:
7987:
7986:chromosome 12
7983:
7979:
7976:
7974:
7971:
7969:
7966:
7964:
7961:
7959:
7956:
7954:
7951:
7949:
7946:
7944:
7941:
7939:
7936:
7934:
7931:
7930:
7929:
7928:
7927:chromosome 17
7924:
7920:
7919:
7917:
7913:
7909:
7906:
7903:
7898:
7891:
7888:
7886:
7883:Intermediate
7880:
7870:
7867:
7865:
7862:
7858:
7855:
7853:
7850:
7848:
7845:
7844:
7843:
7840:
7838:
7835:
7833:
7830:
7829:
7827:
7823:
7813:
7810:
7806:
7803:
7801:
7798:
7797:
7796:
7793:
7791:
7788:
7784:
7781:
7777:
7774:
7772:
7769:
7768:
7767:
7764:
7763:
7762:
7761:
7757:
7755:
7752:
7748:
7745:
7743:
7740:
7738:
7735:
7733:
7730:
7729:
7728:
7725:
7724:
7719:
7716:
7714:
7711:
7709:
7706:
7704:
7701:
7700:
7699:
7696:
7692:
7689:
7686:
7683:
7680:
7678:
7675:
7672:
7669:
7667:
7664:
7661:
7658:
7655:
7654:
7653:
7650:
7646:
7643:
7641:
7638:
7636:
7633:
7631:
7628:
7627:
7626:
7623:
7622:
7620:
7616:
7608:
7605:
7603:
7600:
7598:
7595:
7593:
7590:
7588:
7585:
7583:
7580:
7578:
7575:
7573:
7570:
7568:
7565:
7563:
7560:
7558:
7555:
7553:
7550:
7548:
7545:
7544:
7543:
7540:
7536:
7533:
7531:
7528:
7527:
7525:
7521:
7518:
7517:
7515:
7511:
7508:
7507:
7505:
7501:
7498:
7496:
7493:
7492:
7490:
7486:
7483:
7481:
7478:
7477:
7475:
7471:
7468:
7467:
7465:
7461:
7458:
7456:
7453:
7451:
7448:
7447:
7445:
7441:
7438:
7436:
7433:
7432:
7430:
7426:
7423:
7421:
7418:
7416:
7413:
7411:
7408:
7406:
7403:
7401:
7398:
7396:
7393:
7391:
7388:
7386:
7383:
7381:
7378:
7376:
7373:
7371:
7368:
7366:
7363:
7361:
7358:
7356:
7353:
7352:
7350:
7345:
7342:
7340:
7337:
7335:
7332:
7330:
7327:
7325:
7322:
7320:
7317:
7315:
7312:
7310:
7307:
7306:
7304:
7303:
7301:
7299:
7295:
7289:
7286:
7284:
7281:
7279:
7276:
7274:
7271:
7269:
7266:
7264:
7261:
7260:
7258:
7256:
7252:
7249:
7247:
7243:
7240:
7238:
7233:
7229:
7226:
7222:
7218:
7214:
7207:
7202:
7200:
7195:
7193:
7188:
7187:
7184:
7177:
7173:
7172:
7167:
7163:
7159:
7156:
7153:
7151:
7148:
7145:
7141:
7138:
7137:
7126:
7122:
7117:
7112:
7108:
7104:
7100:
7096:
7092:
7087:
7083:
7079:
7076:(4): 244–57.
7075:
7071:
7066:
7062:
7058:
7053:
7048:
7044:
7040:
7036:
7032:
7028:
7023:
7019:
7015:
7011:
7007:
7002:
6997:
6993:
6989:
6985:
6981:
6977:
6972:
6968:
6964:
6960:
6956:
6952:
6948:
6945:(4): 435–42.
6944:
6940:
6935:
6931:
6927:
6922:
6917:
6913:
6909:
6904:
6900:
6896:
6892:
6888:
6884:
6880:
6876:
6872:
6867:
6863:
6859:
6855:
6851:
6847:
6843:
6839:
6835:
6829:
6825:
6821:
6817:
6813:
6809:
6805:
6800:
6796:
6792:
6787:
6782:
6778:
6774:
6770:
6766:
6761:
6757:
6753:
6749:
6745:
6741:
6737:
6734:(4): 277–95.
6733:
6729:
6724:
6720:
6716:
6713:(2): 119–23.
6712:
6708:
6703:
6699:
6695:
6691:
6687:
6683:
6679:
6675:
6671:
6666:
6662:
6658:
6654:
6650:
6646:
6642:
6639:(4): 258–60.
6638:
6634:
6629:
6625:
6621:
6617:
6613:
6609:
6605:
6600:
6596:
6592:
6588:
6584:
6580:
6576:
6572:
6568:
6563:
6559:
6555:
6551:
6547:
6542:
6538:
6534:
6529:
6524:
6521:(1): 110–21.
6520:
6516:
6512:
6507:
6503:
6499:
6494:
6489:
6484:
6479:
6476:(6): 979–86.
6475:
6471:
6467:
6462:
6458:
6454:
6450:
6446:
6442:
6438:
6434:
6430:
6425:
6421:
6417:
6413:
6409:
6405:
6401:
6397:
6393:
6388:
6387:
6374:
6370:
6365:
6360:
6356:
6352:
6348:
6341:
6333:
6329:
6324:
6319:
6315:
6311:
6307:
6300:
6292:
6288:
6283:
6278:
6274:
6270:
6267:(7): 2240–6.
6266:
6262:
6258:
6251:
6243:
6239:
6234:
6229:
6225:
6221:
6217:
6213:
6209:
6202:
6194:
6190:
6186:
6182:
6178:
6174:
6170:
6166:
6159:
6151:
6147:
6142:
6137:
6133:
6129:
6125:
6118:
6110:
6106:
6101:
6096:
6092:
6088:
6084:
6077:
6069:
6065:
6060:
6055:
6051:
6047:
6043:
6036:
6028:
6016:
6008:
6004:
6000:
5996:
5992:
5986:
5982:
5978:
5974:
5967:
5957:
5953:
5948:
5947:
5944:
5940:
5935:
5930:
5926:
5922:
5918:
5914:
5910:
5903:
5895:
5891:
5886:
5881:
5877:
5873:
5869:
5865:
5861:
5854:
5846:
5842:
5837:
5832:
5828:
5824:
5820:
5816:
5812:
5805:
5797:
5793:
5789:
5785:
5781:
5777:
5773:
5769:
5762:
5754:
5750:
5744:
5736:
5732:
5727:
5722:
5718:
5714:
5710:
5706:
5702:
5695:
5687:
5683:
5678:
5673:
5668:
5663:
5659:
5655:
5651:
5644:
5630:
5626:
5622:
5618:
5611:
5598:
5594:
5588:
5580:
5576:
5571:
5566:
5561:
5556:
5552:
5548:
5544:
5537:
5529:
5525:
5521:
5517:
5513:
5509:
5505:
5501:
5494:
5486:
5482:
5477:
5472:
5467:
5462:
5458:
5454:
5450:
5446:
5442:
5435:
5427:
5423:
5418:
5413:
5408:
5403:
5399:
5395:
5391:
5384:
5376:
5372:
5367:
5362:
5357:
5352:
5348:
5344:
5340:
5333:
5325:
5321:
5317:
5313:
5309:
5305:
5301:
5297:
5290:
5282:
5278:
5274:
5270:
5266:
5262:
5259:(4): 461–71.
5258:
5254:
5247:
5239:
5235:
5231:
5227:
5223:
5219:
5215:
5211:
5204:
5196:
5192:
5187:
5182:
5177:
5172:
5168:
5164:
5160:
5153:
5145:
5141:
5136:
5131:
5127:
5123:
5120:(3): 223–33.
5119:
5115:
5111:
5104:
5096:
5092:
5087:
5082:
5078:
5074:
5070:
5066:
5062:
5055:
5046:
5044:
5035:
5031:
5026:
5021:
5016:
5011:
5007:
5003:
4999:
4995:
4991:
4984:
4976:
4972:
4967:
4962:
4958:
4954:
4950:
4946:
4939:
4931:
4927:
4922:
4917:
4913:
4909:
4906:(1): 164–77.
4905:
4901:
4897:
4890:
4882:
4878:
4874:
4870:
4865:
4860:
4857:(5): 671–82.
4856:
4852:
4848:
4841:
4833:
4829:
4824:
4819:
4815:
4811:
4807:
4803:
4799:
4792:
4784:
4780:
4775:
4770:
4765:
4760:
4756:
4752:
4748:
4741:
4733:
4729:
4724:
4719:
4715:
4711:
4707:
4700:
4692:
4688:
4683:
4678:
4673:
4668:
4664:
4660:
4656:
4649:
4641:
4637:
4632:
4627:
4623:
4619:
4615:
4608:
4600:
4596:
4591:
4586:
4582:
4578:
4571:
4564:
4556:
4552:
4547:
4542:
4537:
4532:
4528:
4524:
4520:
4513:
4505:
4501:
4496:
4491:
4486:
4481:
4477:
4473:
4469:
4465:
4461:
4454:
4446:
4442:
4437:
4432:
4427:
4422:
4418:
4414:
4410:
4406:
4402:
4395:
4387:
4383:
4379:
4375:
4371:
4367:
4363:
4359:
4351:
4343:
4339:
4334:
4329:
4325:
4321:
4317:
4310:
4302:
4298:
4294:
4290:
4286:
4282:
4278:
4274:
4267:
4259:
4255:
4250:
4245:
4241:
4237:
4233:
4226:
4218:
4214:
4209:
4204:
4200:
4196:
4193:(3): 577–91.
4192:
4188:
4184:
4177:
4169:
4165:
4161:
4157:
4153:
4149:
4142:
4134:
4130:
4125:
4120:
4116:
4112:
4108:
4101:
4093:
4089:
4084:
4079:
4075:
4071:
4067:
4063:
4059:
4052:
4044:
4040:
4036:
4032:
4028:
4024:
4021:(9): 1032–7.
4020:
4016:
4008:
4000:
3996:
3991:
3986:
3982:
3978:
3974:
3967:
3959:
3955:
3951:
3947:
3944:(3): 271–80.
3943:
3939:
3931:
3923:
3919:
3914:
3909:
3904:
3899:
3895:
3891:
3887:
3880:
3872:
3868:
3864:
3860:
3857:(2): 411–21.
3856:
3852:
3848:
3841:
3833:
3829:
3824:
3819:
3815:
3811:
3808:(1): 516–31.
3807:
3803:
3799:
3792:
3784:
3780:
3776:
3772:
3768:
3764:
3760:
3756:
3752:
3748:
3741:
3733:
3729:
3725:
3721:
3717:
3713:
3710:(3): 129–32.
3709:
3705:
3698:
3696:
3687:
3683:
3679:
3675:
3671:
3667:
3663:
3659:
3655:
3648:
3640:
3636:
3632:
3628:
3624:
3620:
3616:
3609:
3601:
3597:
3592:
3587:
3583:
3579:
3575:
3571:
3567:
3560:
3552:
3548:
3543:
3538:
3534:
3530:
3525:
3520:
3516:
3512:
3508:
3501:
3493:
3489:
3484:
3479:
3475:
3471:
3468:(3): 1001–7.
3467:
3463:
3459:
3452:
3450:
3441:
3437:
3432:
3427:
3423:
3419:
3415:
3411:
3407:
3403:
3399:
3392:
3384:
3380:
3375:
3370:
3365:
3360:
3356:
3352:
3348:
3341:
3333:
3329:
3325:
3321:
3316:
3311:
3308:(3): 387–97.
3307:
3303:
3299:
3292:
3284:
3280:
3275:
3270:
3265:
3260:
3256:
3252:
3248:
3241:
3233:
3229:
3225:
3221:
3217:
3213:
3210:(2): 148–75.
3209:
3205:
3198:
3196:
3187:
3183:
3179:
3175:
3171:
3167:
3163:
3159:
3155:
3151:
3144:
3142:
3133:
3129:
3124:
3119:
3115:
3111:
3107:
3103:
3099:
3092:
3090:
3088:
3086:
3084:
3082:
3073:
3069:
3065:
3061:
3058:(2): 227–47.
3057:
3053:
3046:
3038:
3034:
3030:
3026:
3023:(2): 207–25.
3022:
3018:
3011:
3009:
3007:
2998:
2994:
2990:
2986:
2982:
2978:
2971:
2963:
2959:
2955:
2951:
2944:
2936:
2932:
2927:
2922:
2917:
2912:
2908:
2904:
2900:
2893:
2885:
2881:
2877:
2873:
2869:
2865:
2862:(4): 519–26.
2861:
2857:
2849:
2841:
2837:
2832:
2827:
2822:
2817:
2813:
2809:
2805:
2801:
2797:
2790:
2782:
2778:
2773:
2768:
2763:
2758:
2754:
2750:
2746:
2742:
2738:
2731:
2729:
2720:
2716:
2710:
2702:
2698:
2692:
2685:
2681:
2676:
2674:
2672:
2664:
2660:
2655:
2653:
2651:
2646:
2636:
2633:
2631:
2628:
2626:
2623:
2621:
2618:
2616:
2613:
2611:
2608:
2605:
2603:
2600:
2598:
2595:
2593:
2590:
2587:
2584:
2583:
2573:
2570:
2567:
2564:
2562:
2559:
2556:
2553:
2550:
2547:
2546:
2545:
2543:
2533:
2531:
2527:
2523:
2519:
2515:
2505:
2503:
2499:
2496:, especially
2495:
2491:
2481:
2479:
2474:
2472:
2467:
2465:
2461:
2457:
2451:
2449:
2445:
2441:
2437:
2433:
2429:
2423:
2421:
2417:
2413:
2403:
2401:
2395:
2393:
2389:
2385:
2381:
2377:
2373:
2369:
2365:
2361:
2360:self-assembly
2357:
2353:
2348:
2338:
2336:
2332:
2328:
2324:
2320:
2310:
2308:
2304:
2300:
2296:
2292:
2288:
2278:
2269:
2267:
2265:
2259:
2257:
2253:
2249:
2245:
2241:
2237:
2233:
2228:
2226:
2222:
2218:
2213:
2209:
2199:
2197:
2194:gene has two
2193:
2188:
2186:
2182:
2178:
2174:
2170:
2166:
2162:
2158:
2154:
2144:
2142:
2138:
2134:
2130:
2126:
2125:transcriptome
2122:
2118:
2114:
2110:
2106:
2096:
2094:
2090:
2085:
2083:
2079:
2074:
2072:
2068:
2058:
2056:
2052:
2048:
2045:
2041:
2037:
2036:
2031:
2021:
2019:
2015:
2010:
2008:
2004:
2000:
1996:
1992:
1988:
1983:
1981:
1980:knockout mice
1977:
1973:
1970:
1952:
1948:
1943:
1939:
1934:
1930:
1928:
1924:
1920:
1916:
1912:
1908:
1904:
1899:
1897:
1893:
1889:
1885:
1881:
1877:
1873:
1869:
1865:
1862:
1858:
1854:
1850:
1846:
1842:
1838:
1825:
1820:
1816:
1812:
1809:
1805:
1798:
1796:
1793:
1789:
1785:
1781:
1778:
1774:
1770:
1763:
1761:
1757:
1753:
1749:
1745:
1741:
1737:
1733:
1729:
1725:
1721:
1717:
1713:
1709:
1705:
1701:
1697:
1693:
1689:
1685:
1681:
1677:
1673:
1669:
1665:
1661:
1657:
1651:
1647:
1643:
1639:
1635:
1631:
1627:
1624:
1618:
1616:
1612:
1608:
1604:
1600:
1596:
1592:
1586:
1582:
1578:
1574:
1570:
1566:
1562:
1559:
1555:
1548:
1546:
1542:
1538:
1534:
1530:
1524:
1520:
1517:
1511:
1509:
1505:
1501:
1497:
1493:
1489:
1485:
1479:
1475:
1471:
1467:
1463:
1459:
1455:
1452:
1450:RefSeq (mRNA)
1448:
1441:
1440:
1435:
1431:
1428:
1422:
1421:
1416:
1412:
1409:
1407:
1403:
1396:
1395:
1390:
1386:
1383:
1377:
1376:
1372:
1368:
1363:
1359:
1356:
1354:
1350:
1343:
1342:
1337:
1333:
1330:
1324:
1323:
1318:
1314:
1311:
1309:
1305:
1302:
1299:
1297:
1294:
1290:
1287:
1283:
1279:
1272:
1268:
1263:
1257:
1254:
1252:
1249:
1247:
1244:
1242:
1239:
1237:
1234:
1232:
1229:
1227:
1224:
1222:
1219:
1217:
1214:
1212:
1209:
1207:
1204:
1202:
1199:
1197:
1194:
1192:
1189:
1187:
1184:
1182:
1179:
1177:
1174:
1172:
1169:
1167:
1164:
1162:
1159:
1157:
1154:
1152:
1149:
1147:
1144:
1142:
1139:
1137:
1134:
1132:
1129:
1127:
1124:
1122:
1119:
1117:
1114:
1112:
1109:
1107:
1104:
1102:
1099:
1097:
1094:
1092:
1089:
1087:
1084:
1082:
1079:
1077:
1074:
1072:
1069:
1067:
1064:
1062:
1059:
1057:
1054:
1052:
1049:
1047:
1044:
1042:
1039:
1037:
1034:
1032:
1029:
1027:
1024:
1022:
1019:
1017:
1014:
1012:
1009:
1007:
1004:
1002:
999:
997:
994:
992:
989:
987:
984:
983:
981:
978:
977:
971:
968:
966:
965:membrane raft
963:
961:
958:
956:
953:
951:
948:
946:
943:
941:
938:
936:
935:mitochondrion
933:
931:
928:
926:
923:
921:
918:
916:
913:
911:
908:
906:
903:
901:
900:nuclear speck
898:
896:
893:
891:
888:
886:
883:
881:
878:
876:
873:
871:
868:
866:
863:
861:
858:
856:
853:
851:
848:
846:
843:
841:
838:
836:
833:
831:
828:
826:
823:
821:
818:
817:
815:
812:
811:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
709:actin binding
707:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
671:
669:
666:
665:
662:
661:Gene ontology
658:
654:
642:
637:
633:
626:
619:
614:
611:
609:
605:
597:
592:
581:
577:
574:temporal lobe
573:
569:
565:
561:
557:
553:
549:
545:
544:
541:
537:
532:
529:
520:temporal lobe
519:
515:
511:
507:
503:
499:
495:
491:
487:
483:
482:
479:
475:
470:
467:
466:
463:
461:
457:
455:
454:
450:
449:
446:
444:
440:
436:
432:
428:
420:
415:
411:
407:
402:
392:
388:
381:
374:
368:
361:
353:
349:
345:
340:
336:
331:
327:
319:
314:
310:
306:
301:
291:
287:
280:
273:
267:
260:
256:
250:
246:
242:
237:
233:
228:
224:
220:
216:
212:
208:
204:
200:
196:
192:
188:
184:
176:
171:
164:
159:
154:
143:
141:
137:
133:
129:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
85:
81:
77:
73:
67:
62:
59:
58:
54:
51:
44:
40:
35:
31:
27:
22:
19:
9496:
9271:Dystroglycan
9226:Beta catenin
9127:
8458:Microtubules
8326:Beta-keratin
8255:
8204:
8150:
8090:
8012:
7998:
7984:
7921:
7758:
7625:Tropomodulin
7217:cytoskeleton
7169:
7140:tau+Proteins
7098:
7094:
7073:
7069:
7034:
7030:
6986:(1): 63–73.
6983:
6979:
6942:
6938:
6911:
6874:
6870:
6837:
6833:
6807:
6803:
6771:(4): 164–9.
6768:
6764:
6731:
6727:
6710:
6706:
6676:(4): 261–4.
6673:
6669:
6636:
6632:
6607:
6603:
6570:
6566:
6549:
6545:
6518:
6514:
6473:
6469:
6432:
6428:
6398:(5): 193–9.
6395:
6391:
6354:
6350:
6340:
6313:
6309:
6299:
6264:
6260:
6250:
6215:
6211:
6201:
6168:
6164:
6158:
6131:
6127:
6117:
6090:
6086:
6076:
6049:
6045:
6035:
5972:
5966:
5955:
5916:
5912:
5902:
5867:
5863:
5853:
5818:
5814:
5804:
5771:
5768:Neurosurgery
5767:
5761:
5752:
5743:
5708:
5704:
5694:
5657:
5653:
5643:
5632:. Retrieved
5620:
5610:
5600:, retrieved
5596:
5587:
5550:
5546:
5536:
5503:
5499:
5493:
5448:
5444:
5434:
5397:
5393:
5383:
5346:
5342:
5332:
5299:
5295:
5289:
5256:
5252:
5246:
5216:(1): 26–35.
5213:
5209:
5203:
5169:(1): 55–61.
5166:
5162:
5152:
5117:
5113:
5103:
5068:
5064:
5054:
4997:
4993:
4983:
4951:(4): 164–9.
4948:
4944:
4938:
4903:
4899:
4889:
4854:
4850:
4840:
4805:
4801:
4791:
4754:
4750:
4740:
4713:
4709:
4699:
4662:
4658:
4648:
4621:
4617:
4607:
4580:
4577:Cell Reports
4576:
4563:
4526:
4522:
4512:
4467:
4463:
4453:
4408:
4404:
4394:
4361:
4357:
4350:
4323:
4319:
4309:
4276:
4272:
4266:
4239:
4235:
4225:
4190:
4186:
4176:
4151:
4147:
4141:
4117:(5): 416–9.
4114:
4110:
4100:
4065:
4061:
4051:
4018:
4014:
4007:
3980:
3976:
3966:
3941:
3937:
3930:
3893:
3889:
3879:
3854:
3850:
3840:
3805:
3802:Neuroscience
3801:
3791:
3750:
3746:
3740:
3707:
3703:
3661:
3657:
3647:
3622:
3618:
3608:
3573:
3569:
3559:
3514:
3510:
3500:
3465:
3461:
3405:
3401:
3391:
3354:
3350:
3340:
3305:
3301:
3291:
3254:
3250:
3240:
3207:
3203:
3153:
3149:
3105:
3101:
3055:
3051:
3045:
3020:
3016:
2980:
2976:
2970:
2953:
2949:
2943:
2906:
2902:
2892:
2859:
2855:
2848:
2803:
2799:
2789:
2744:
2740:
2718:
2709:
2700:
2691:
2539:
2536:Interactions
2511:
2487:
2475:
2468:
2464:beta-amyloid
2452:
2424:
2409:
2396:
2368:pathogenesis
2350:
2316:
2294:
2284:
2275:
2263:
2260:
2244:phosphatases
2234:, including
2229:
2205:
2191:
2189:
2152:
2150:
2131:or in brain
2102:
2086:
2081:
2075:
2064:
2047:
2033:
2027:
2011:
1993:portions of
1984:
1972:
1969:microtubules
1966:
1900:
1872:microtubules
1863:
1855:produced by
1848:
1844:
1840:
1837:tau proteins
1836:
1834:
1760:NP_001390945
1756:NP_001390944
1752:NP_001390943
1748:NP_001390941
1744:NP_001390940
1740:NP_001390939
1736:NP_001390935
1732:NP_001390934
1728:NP_001390933
1724:NP_001390931
1720:NP_001390928
1716:NP_001390927
1712:NP_001390925
1708:NP_001390923
1704:NP_001390921
1700:NP_001390919
1696:NP_001390916
1692:NP_001390913
1688:NP_001390912
1684:NP_001390911
1680:NP_001390910
1676:NP_001390909
1672:NP_001390908
1668:NP_001390907
1664:NP_001390906
1660:NP_001390905
1656:NP_001390904
1653:
1642:NP_001272385
1638:NP_001272384
1634:NP_001272383
1630:NP_001033698
1615:NP_001364197
1611:NP_001364196
1607:NP_001364195
1603:NP_001364194
1588:
1577:NP_001190181
1573:NP_001190180
1569:NP_001116539
1565:NP_001116538
1545:NM_001285456
1541:NM_001285455
1537:NM_001285454
1529:NM_001038609
1526:
1508:NM_001377268
1504:NM_001377267
1500:NM_001377266
1496:NM_001377265
1481:
1470:NM_001203252
1466:NM_001203251
1462:NM_001123067
1458:NM_001123066
1437:
1418:
1392:
1365:
1339:
1320:
1300:
1295:
870:cytoskeleton
512:hypothalamus
458:
451:
417:104,332,090
404:104,231,390
178:External IDs
69:
18:
9417:Plakophilin
9368:Desmoplakin
9128:Tau protein
7902:Cytokeratin
7698:Tropomyosin
7246:Myofilament
7037:(1): 1–10.
5973:Tau Biology
5302:(1): 22–6.
3658:NeuroReport
2620:Proteopathy
2514:tauopathies
2478:immunoassay
2458:as well as
2444:cytoplasmic
2380:tauopathies
2303:hippocampal
2196:haplogroups
2129:myelination
2071:habituation
2030:translation
885:microtubule
840:growth cone
754:RNA binding
704:DNA binding
316:46,028,334
303:45,894,527
156:Identifiers
9513:Categories
9497:See also:
9469:Crescentin
9388:Periplakin
9378:Envoplakin
9266:Dystrophin
8883:axonemal:
8377:Internexin
8356:Peripherin
6786:10316/4769
5634:2020-07-29
5602:2020-01-27
5553:(1): 462.
5349:(3): 260.
4966:10316/4769
3517:(1): 110.
3357:(1): 204.
2686:, May 2017
2665:, May 2017
2642:References
2434:, such as
2432:polyanions
2402:proteins.
2378:and other
2356:inclusions
2223:(Ser) and
2181:C-terminal
2141:depression
2121:chromosome
2082:Drosophila
2035:Drosophila
1892:astrocytes
1847:ssociated
462:(ortholog)
199:HomoloGene
9086:Centrin 3
9081:Centrin 2
9076:Centrin 1
8414:Syncoilin
8319:Not alpha
7885:filaments
7837:Fibrillin
6493:1765/9318
6025:ignored (
6015:cite book
6007:211475911
5796:196391183
5629:0362-4331
4665:(1): 31.
3896:(1): 91.
3533:2051-5960
3422:0261-4189
2909:(1): 52.
2586:Tauopathy
2440:ubiquitin
2388:misfolded
2347:Tauopathy
2307:microglia
2272:Mechanism
2225:threonine
2202:Structure
2117:apoptosis
2040:ribosomes
1987:dendrites
1903:dementias
1859:from the
1646:NP_034968
1599:NP_058525
1595:NP_058519
1591:NP_058518
1581:NP_005901
1533:NM_010838
1492:NM_016841
1488:NM_016835
1484:NM_016834
1474:NM_005910
1286:Orthologs
960:main axon
825:cell body
820:cytoplasm
566:CA3 field
207:GeneCards
9524:Proteins
9452:Nonhuman
9412:Vinculin
9373:Dystonin
9305:Spectrin
9278:Utrophin
9258:Membrane
9213:Catenins
9145:Stathmin
9133:Dynactin
9013:DYNC2LI1
9008:DYNC1LI2
9003:DYNC1LI1
8668:Kinesins
8472:Tubulins
8361:Vimentin
7893:Type 1/2
7795:Profilin
7790:Gelsolin
7652:Troponin
7213:Proteins
7082:16416389
7061:17555970
7018:40879765
7010:17493040
6967:36430988
6959:17373874
6930:16987883
6899:19357113
6891:16958643
6854:16793187
6824:16042549
6795:15823754
6756:28578030
6748:15365985
6719:15266787
6698:36197015
6690:15178932
6661:27693523
6653:15178931
6624:12470988
6595:24891421
6587:11831556
6558:11831025
6537:10899436
6502:10767321
6457:22471158
6420:44928661
6373:10840038
6291:11264299
6242:11826099
6185:14528052
6150:10464279
6109:31257249
6068:24493463
5999:32096046
5943:22116192
5894:23208308
5845:22593173
5788:15987548
5735:32722745
5686:32725127
5579:35008886
5528:23900723
5426:25339173
5375:30893872
5324:37380445
5316:11801334
5281:38730940
5273:10959034
5230:11837744
5195:19742193
5144:22561167
5095:27878758
5034:11381127
4975:15823754
4930:18930955
4881:18896805
4873:15006350
4832:26436904
4783:29238289
4732:28772101
4691:30823892
4640:30580037
4599:25981034
4555:19282288
4445:15249677
4386:40592137
4301:94265621
4258:11104762
4168:16042549
4133:18648385
4111:Heredity
4092:19165922
4043:38047848
4035:16906163
3999:15615637
3922:29187252
3871:20555133
3832:20434528
3783:32771613
3775:17478722
3732:31204860
3724:10688046
3686:25235996
3678:17558294
3639:11228161
3600:30759285
3551:34147135
3492:26791227
3440:31268600
3383:15642108
3332:18776289
3324:20655099
3283:22720190
3232:32708424
3224:18448228
3132:31488613
2997:20678581
2935:35765081
2884:19627629
2682:–
2661:–
2579:See also
2542:interact
2428:protease
2392:synapses
2313:Toxicity
2173:isoforms
2147:Genetics
2061:Behavior
2003:isoforms
1958:Function
1909:such as
1808:Wikidata
1265:Sources:
945:axolemma
895:membrane
860:dendrite
295:17q21.31
9439:PLEKHA7
9393:Plectin
9358:Plakins
9283:Ankyrin
9182:Dynamin
9112:Spastin
9107:Katanin
9071:CAMSAP3
9066:CAMSAP2
9061:CAMSAP1
9033:DYNLRB2
9028:DYNLRB1
8998:DYNC1I2
8993:DYNC1I1
8988:DYNC2H1
8983:DYNC1H1
8876:Dyneins
8600:TUBGCP6
8595:TUBGCP5
8590:TUBGCP4
8585:TUBGCP3
8580:TUBGCP2
8409:Synemin
8152:type II
8014:type II
7897:Keratin
7842:Filamin
7783:Destrin
7766:Cofilin
7727:Actinin
7298:Myosins
7215:of the
7176:PDBe-KB
7166:UniProt
7125:3139677
7116:2115262
7052:2801069
7001:8095608
6862:6848053
6449:7566346
6412:1713721
6332:2833519
6282:6762409
6233:6758498
6193:9086733
5934:3326246
5885:3624697
5836:3739428
5726:7388060
5677:7596823
5570:8745479
5520:2126970
5485:8393578
5453:Bibcode
5417:4256367
5366:6468864
5238:6799990
5186:2738403
5135:3399531
5086:5684262
5002:Bibcode
4921:2644648
4823:4694577
4774:5712583
4757:: 667.
4682:6397507
4546:2676015
4504:8990203
4472:Bibcode
4413:Bibcode
4378:7946342
4342:7983034
4293:1560225
4217:9169588
4208:1218358
4083:2684794
3958:3103857
3913:5707803
3823:2900546
3755:Bibcode
3747:Science
3591:6426815
3542:8214309
3483:4719006
3431:6600635
3274:3375147
3186:4322543
3178:8202139
3158:Bibcode
3123:6794924
2962:1903170
2926:9241296
2876:2484340
2840:3131773
2808:Bibcode
2781:1057175
2749:Bibcode
2684:Ensembl
2663:Ensembl
2524:. True
2516:, like
2364:tangles
2301:to the
2281:Release
2266:-GlcNAc
2232:kinases
2208:domains
2165:encoded
2143:, etc.
2139:and in
2133:insulin
1999:tubulin
1905:of the
1882:of the
1880:neurons
1843:ubulin
1406:UniProt
1353:Ensembl
1292:Species
1271:QuickGO
880:cytosol
875:nucleus
437:pattern
163:Aliases
9340:SPTBN5
9335:SPTBN4
9330:SPTBN2
9325:SPTBN1
9315:SPTAN1
9150:Tektin
9043:DYNLT3
9038:DYNLT1
9023:DYNLL2
9018:DYNLL1
8965:DNALI1
8950:DNAH17
8945:DNAH14
8940:DNAH13
8935:DNAH12
8930:DNAH11
8925:DNAH10
8846:KIF26B
8841:KIF26A
8816:KIF21B
8811:KIF21A
8806:KIF20B
8801:KIF20A
8791:KIF18B
8786:KIF18A
8776:KIF16B
8761:KIF13B
8756:KIF13A
8555:TUBB4Q
8540:TUBB2C
8535:TUBB2B
8530:TUBB2A
8510:TUBA4A
8505:TUBA3E
8500:TUBA3D
8495:TUBA3C
8490:TUBA1C
8485:TUBA1B
8480:TUBA1A
8423:Type 5
8382:Nestin
8370:Type 4
8346:Desmin
8339:Type 3
8092:type I
7923:type I
7869:TRIOBP
7535:MYO18B
7530:MYO18A
7526:XVIII
7520:MYO15A
7255:Actins
7171:P10636
7146:(MeSH)
7123:
7113:
7080:
7059:
7049:
7016:
7008:
6998:
6965:
6957:
6928:
6897:
6889:
6860:
6852:
6822:
6793:
6754:
6746:
6717:
6696:
6688:
6659:
6651:
6622:
6593:
6585:
6556:
6535:
6500:
6455:
6447:
6418:
6410:
6371:
6330:
6289:
6279:
6240:
6230:
6191:
6183:
6148:
6107:
6066:
6005:
5997:
5987:
5941:
5931:
5892:
5882:
5843:
5833:
5794:
5786:
5733:
5723:
5684:
5674:
5660:(11).
5627:
5577:
5567:
5526:
5518:
5483:
5473:
5424:
5414:
5373:
5363:
5322:
5314:
5279:
5271:
5236:
5228:
5193:
5183:
5142:
5132:
5093:
5083:
5032:
5022:
4973:
4928:
4918:
4879:
4871:
4830:
4820:
4781:
4771:
4730:
4689:
4679:
4638:
4597:
4553:
4543:
4502:
4492:
4443:
4436:490015
4433:
4384:
4376:
4358:Neuron
4340:
4299:
4291:
4256:
4215:
4205:
4166:
4131:
4090:
4080:
4041:
4033:
3997:
3956:
3920:
3910:
3869:
3830:
3820:
3781:
3773:
3730:
3722:
3684:
3676:
3637:
3598:
3588:
3549:
3539:
3531:
3490:
3480:
3438:
3428:
3420:
3381:
3374:549057
3371:
3330:
3322:
3281:
3271:
3230:
3222:
3184:
3176:
3150:Nature
3130:
3120:
3072:146092
3070:
3037:599557
3035:
2995:
2960:
2933:
2923:
2882:
2874:
2856:Neuron
2838:
2831:280359
2828:
2779:
2772:432646
2769:
2544:with:
2526:prions
2456:kinase
2221:serine
2095:time.
1991:distal
1794:search
1792:PubMed
1439:P10637
1420:P10636
1308:Entrez
1031:memory
608:BioGPS
187:157140
9400:Talin
9383:MACF1
9351:Other
9310:SPTA1
9175:TEKT5
9170:TEKT4
9165:TEKT3
9160:TEKT2
9155:TEKT1
9138:DCTN1
9121:Other
8975:DNAL4
8970:DNAL1
8960:DNAI2
8955:DNAI1
8920:DNAH9
8915:DNAH8
8910:DNAH7
8905:DNAH6
8900:DNAH5
8895:DNAH3
8890:DNAH2
8885:DNAH1
8866:KIFC3
8861:KIFC2
8856:KIFC1
8851:KIF27
8836:KIF25
8831:KIF24
8826:KIF23
8821:KIF22
8796:KIF19
8781:KIF17
8771:KIF15
8766:KIF14
8751:KIF12
8746:KIF11
8726:KIF5C
8721:KIF5B
8716:KIF5A
8711:KIF4B
8706:KIF4A
8701:KIF3C
8696:KIF3B
8691:KIF2C
8686:KIF2A
8681:KIF1B
8676:KIF1A
8648:MAP1B
8643:MAP1A
8610:TUBE1
8605:TUBD1
8575:TUBG2
8570:TUBG1
8565:TUBB8
8560:TUBB6
8550:TUBB4
8545:TUBB3
8525:TUBB1
8515:TUBA8
7864:Espin
7825:Other
7812:Titin
7618:Other
7607:MYLL1
7602:MYLK2
7592:MYLIP
7577:MYL6B
7510:MYO10
7500:MYO9B
7495:MYO9A
7485:MYO7B
7480:MYO7A
7460:MYO5C
7455:MYO5B
7450:MYO5A
7440:MYO3B
7435:MYO3A
7425:MYH16
7420:MYH15
7415:MYH14
7410:MYH13
7405:MYH11
7400:MYH10
7385:MYH7B
7344:MYO1H
7339:MYO1G
7334:MYO1F
7329:MYO1E
7324:MYO1D
7319:MYO1C
7314:MYO1B
7309:MYO1A
7224:Human
7014:S2CID
6963:S2CID
6895:S2CID
6858:S2CID
6752:S2CID
6694:S2CID
6657:S2CID
6591:S2CID
6453:S2CID
6416:S2CID
6189:S2CID
6003:S2CID
5913:Brain
5864:Brain
5792:S2CID
5593:"A68"
5524:S2CID
5476:47025
5343:Cells
5320:S2CID
5277:S2CID
5234:S2CID
5114:Prion
5025:34454
4877:S2CID
4573:(PDF)
4495:19321
4382:S2CID
4297:S2CID
4039:S2CID
3779:S2CID
3728:S2CID
3682:S2CID
3328:S2CID
3228:S2CID
3182:S2CID
2880:S2CID
2635:Prion
2572:YWHAZ
2568:, and
2566:S100B
2400:prion
2323:GSK-3
2319:PAR-1
2161:exons
1995:axons
1876:axons
1341:17762
1301:Mouse
1296:Human
1267:Amigo
460:Mouse
453:Human
400:Start
335:Mouse
299:Start
232:Human
203:74962
195:97180
9484:ParM
9479:MreB
9474:FtsZ
9434:ACF7
9427:PKP2
9422:PKP1
9405:TLN1
9320:SPTB
9298:ANK3
9293:ANK2
9288:ANK1
9197:DNM3
9192:DNM2
9187:DNM1
9091:PCM1
8741:KIF9
8736:KIF7
8731:KIF6
8658:MAP4
8653:MAP2
8620:MAPs
8520:TUBB
8463:MAPs
8461:and
8402:NEFH
8397:NEFM
8392:NEFL
8351:GFAP
7999:none
7857:FLNC
7852:FLNB
7847:FLNA
7597:MYLK
7587:MYL9
7582:MYL7
7572:MYL6
7567:MYL5
7562:MYL4
7557:MYL3
7552:MYL2
7547:MYL1
7476:VII
7470:MYO6
7431:III
7395:MYH9
7390:MYH8
7380:MYH7
7375:MYH6
7370:MYH4
7365:MYH3
7360:MYH2
7355:MYH1
7237:ABPs
7235:and
7164:for
7121:PMID
7078:PMID
7057:PMID
7006:PMID
6955:PMID
6926:PMID
6887:PMID
6850:PMID
6820:PMID
6791:PMID
6744:PMID
6715:PMID
6686:PMID
6649:PMID
6620:PMID
6583:PMID
6554:PMID
6533:PMID
6519:1502
6498:PMID
6445:PMID
6408:PMID
6369:PMID
6328:PMID
6287:PMID
6238:PMID
6181:PMID
6146:PMID
6105:PMID
6064:PMID
6027:help
5995:PMID
5985:ISBN
5939:PMID
5890:PMID
5841:PMID
5784:PMID
5753:NOVA
5731:PMID
5705:JAMA
5682:PMID
5625:ISSN
5575:PMID
5516:PMID
5481:PMID
5422:PMID
5371:PMID
5312:PMID
5269:PMID
5226:PMID
5191:PMID
5140:PMID
5091:PMID
5030:PMID
4971:PMID
4926:PMID
4869:PMID
4851:Cell
4828:PMID
4779:PMID
4728:PMID
4687:PMID
4636:PMID
4595:PMID
4551:PMID
4500:PMID
4441:PMID
4374:PMID
4338:PMID
4289:PMID
4254:PMID
4213:PMID
4164:PMID
4129:PMID
4088:PMID
4031:PMID
3995:PMID
3981:1739
3954:PMID
3918:PMID
3867:PMID
3828:PMID
3771:PMID
3720:PMID
3674:PMID
3635:PMID
3596:PMID
3547:PMID
3529:ISSN
3488:PMID
3436:PMID
3418:ISSN
3379:PMID
3320:PMID
3302:Cell
3279:PMID
3255:2012
3220:PMID
3174:PMID
3128:PMID
3068:PMID
3033:PMID
2993:PMID
2958:PMID
2931:PMID
2872:PMID
2836:PMID
2777:PMID
2530:PRNP
2520:and
2410:The
2327:CDK5
2325:and
2295:MAPT
2252:PP2B
2250:and
2248:PP2A
2238:, a
2192:MAPT
2190:The
2153:MAPT
2115:and
2055:rpS6
2005:and
1947:DAPI
1938:MAP2
1913:and
1894:and
1864:MAPT
1861:gene
1835:The
1322:4137
905:axon
443:Bgee
391:Band
352:Chr.
290:Band
249:Chr.
211:MAPT
183:OMIM
170:MAPT
140:5E2V
136:5E2W
132:5HF3
128:4Y3B
124:5DMG
120:4Y32
116:4Y5I
112:4TQE
108:2MZ7
104:4NP8
100:4FL5
96:4E0O
92:4E0N
88:4E0M
84:3OVL
80:2ON9
76:4GLR
72:1I8H
53:RCSB
50:PDBe
24:MAPT
9248:GAN
9231:APC
8638:EB3
8633:EB2
8628:EB1
8434:A/C
8117:33B
8112:33A
7516:XV
7491:IX
7466:VI
7351:II
7162:PDB
7111:PMC
7103:doi
7099:107
7047:PMC
7039:doi
6996:PMC
6988:doi
6947:doi
6916:doi
6879:doi
6842:doi
6812:doi
6781:hdl
6773:doi
6736:doi
6678:doi
6641:doi
6612:doi
6575:doi
6523:doi
6488:hdl
6478:doi
6437:doi
6400:doi
6359:doi
6355:275
6318:doi
6314:263
6277:PMC
6269:doi
6228:PMC
6220:doi
6173:doi
6136:doi
6132:274
6095:doi
6091:139
6054:doi
5977:doi
5929:PMC
5921:doi
5917:135
5880:PMC
5872:doi
5868:136
5831:PMC
5823:doi
5776:doi
5721:PMC
5713:doi
5709:324
5672:PMC
5662:doi
5658:217
5565:PMC
5555:doi
5508:doi
5504:531
5471:PMC
5461:doi
5412:PMC
5402:doi
5398:289
5361:PMC
5351:doi
5304:doi
5261:doi
5218:doi
5214:103
5181:PMC
5171:doi
5130:PMC
5122:doi
5081:PMC
5073:doi
5020:PMC
5010:doi
4961:hdl
4953:doi
4916:PMC
4908:doi
4859:doi
4855:116
4818:PMC
4810:doi
4769:PMC
4759:doi
4718:doi
4677:PMC
4667:doi
4626:doi
4622:431
4585:doi
4541:PMC
4531:doi
4527:284
4490:PMC
4480:doi
4431:PMC
4421:doi
4409:101
4366:doi
4328:doi
4324:269
4281:doi
4244:doi
4240:276
4203:PMC
4195:doi
4191:323
4156:doi
4119:doi
4115:101
4078:PMC
4070:doi
4023:doi
3985:doi
3946:doi
3942:387
3908:PMC
3898:doi
3859:doi
3818:PMC
3810:doi
3806:169
3763:doi
3751:316
3712:doi
3708:279
3666:doi
3627:doi
3623:114
3586:PMC
3578:doi
3574:137
3537:PMC
3519:doi
3478:PMC
3470:doi
3426:PMC
3410:doi
3369:PMC
3359:doi
3310:doi
3306:142
3269:PMC
3259:doi
3212:doi
3166:doi
3154:369
3118:PMC
3110:doi
3060:doi
3056:116
3025:doi
3021:116
2985:doi
2921:PMC
2911:doi
2864:doi
2826:PMC
2816:doi
2767:PMC
2757:doi
2555:FYN
2370:of
2362:of
2236:PKN
2185:CNS
2032:in
1874:in
413:End
312:End
215:OMA
191:MGI
43:PDB
9515::
8444:B2
8439:B1
8432::
8308:80
8303:79
8298:78
8293:77
8288:76
8283:75
8278:74
8273:73
8268:72
8263:71
8247:40
8242:39
8237:28
8232:27
8227:26
8222:25
8217:24
8212:23
8187:86
8182:85
8177:84
8172:83
8167:82
8162:81
8142:38
8137:37
8132:36
8127:35
8122:34
8107:32
8102:31
8059:6C
8054:6B
8049:6A
8029:2A
8004:21
7992:18
7978:20
7973:19
7968:17
7963:16
7958:15
7953:14
7948:13
7943:12
7938:10
7542:LC
7506:X
7446:V
7305:I
7288:G2
7283:G1
7278:C1
7268:A2
7263:A1
7168::
7119:.
7109:.
7097:.
7093:.
7074:43
7072:.
7055:.
7045:.
7035:27
7033:.
7029:.
7012:.
7004:.
6994:.
6984:17
6982:.
6978:.
6961:.
6953:.
6943:11
6941:.
6924:.
6910:.
6893:.
6885:.
6875:36
6873:.
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6848:.
6838:30
6836:.
6818:.
6808:33
6806:.
6789:.
6779:.
6769:11
6767:.
6750:.
6742:.
6732:24
6730:.
6711:42
6709:.
6692:.
6684:.
6674:17
6672:.
6655:.
6647:.
6637:17
6635:.
6618:.
6606:.
6589:.
6581:.
6571:24
6569:.
6550:73
6548:.
6531:.
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6433:16
6431:.
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6326:.
6312:.
6308:.
6285:.
6275:.
6265:21
6263:.
6259:.
6236:.
6226:.
6216:22
6214:.
6210:.
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