497:
138:
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32:
893:, where the medical benefit of the scan outweighs the potential risk of radiation exposure. For the same reason, the administered activity is kept low. This can potentially result in noisy images, which in turn causes inconclusive mammograms. Researchers continue to devote their time to improving the technology, changing scan parameters, and reducing dose to patients.
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746:
Two sets of images are acquired. For one set, Tc MIBI is injected while the patient is at rest and then the myocardium is imaged. In the second set, the patient is stressed either by exercising on a treadmill or pharmacologically. The drug is injected at peak stress and then imaging is performed. The
801:
as a result of homeostatic dysregulation. The parathyroid gland takes up Tc MIBI following an intravenous injection, and the patient's neck is imaged with a gamma camera to show the location of all glands. A second image is obtained after a washout time (approximately 2 hours), and mitochondria in
869:
More recently, breast radiologists administer lower doses of Tc sestamibi (approximately 150–300 MBq or 4–8 mCi) for
Molecular Breast Imaging (MBI) scans which results in a high sensitivity (91%) and high specificity (93%) for breast cancer detection. It however carries a greater risk of
881:
The last reference listed refers to a 740-megabecquerel (20-millicurie) dose, which is given with the Dilon single-head system, which requires a higher dose since only one camera is utilized (meaning the camera needs to be able to see through more tissue). A 150–300 MBq (4–8 mCi) dose,
861:
The drug is also used in the evaluation of breast nodules. Malignant breast tissues concentrate Tc MIBI to a much greater extent and more frequently than benign disease. As such, limited characterization of breast anomalies is possible. Scintimammography has a high
806:
of the abnormal glands retaining the Tc are seen with the gamma camera. This imaging method will detect 75 to 90 percent of abnormal parathyroid glands in primary hyperparathyroidism. An endocrine surgeon can then perform a focused
179:
1201:
Rhodes DJ, Hruska CB, Phillips SW, Whaley DH, O'Connor MK (January 2011). "Dedicated dual-head gamma imaging for breast cancer screening in women with mammographically dense breasts".
1425:
759:
of around 90%. Resting images are useful only for detecting tissue damage, while stress images will also provide evidence of coronary artery (ischemia) disease.
3318:
2112:
683:
204:
1158:
Liberman M, Sampalis F, Mulder DS, Sampalis JS (July 2003). "Breast cancer diagnosis by scintimammography: a meta-analysis and review of the literature".
3383:
96:
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2717:
1418:
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which is used in the other two commercially available MBI systems is essentially equivalent to a mammogram (150 MBq or 4 mCi) or a
68:
49:
607:
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2138:
587:
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2072:
1389:
75:
3187:
2232:
2459:
1281:"Comparison of radiation exposure and associated radiation-induced cancer risks from mammography and molecular imaging of the breast"
1056:
Untch BR, Barfield ME, Bason J, Olson JA (December 2007). "Minimally invasive radio-guided surgery for primary hyperparathyroidism".
3295:
1411:
82:
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988:"Effect of nitroglycerin on the coronary circulation in patients with coronary artery disease or increased left ventricular work"
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64:
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2671:
1778:
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3102:
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2751:
1795:
889:
In order to keep the radiation doses to patients as low as reasonably achievable, MBI is usually limited to women with
3408:
3393:
2681:
1790:
1338:"Development of radiation dose reduction techniques for cadmium zinc telluride detectors in molecular breast imaging"
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621:
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Underwood SR, Anagnostopoulos C, Cerqueira M, Ell PJ, Flint EJ, Harbinson M, et al. (February 2004).
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1697:
863:
835:
Several case reports have demonstrated that Tc MIBI scan may be useful to differentiate the sub-type of
790:
756:
663:
became available late
September 2008. A scan of a patient using MIBI is commonly known as a "MIBI scan".
476:
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2009:
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8:
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proportionally to the myocardial blood flow. Single photon emission computed tomography (
675:
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793:, one or more of the four parathyroid glands either develops a benign tumor called an
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2004:
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Following administration, Tc MIBI collects in overactive parathyroid glands. During
2939:
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2522:
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1489:
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1308:
1300:
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595:(C#CC(C)(C)OC)(C#CC(C)(C)OC)(C#CC(C)(C)OC)(C#CC(C)(C)OC)(C#CC(C)(C)OC)C#CC(C)(C)OC
3148:
2600:
2566:
2539:
2534:
2468:
1941:
1861:
1514:
1393:
1101:"99mTc MIBI Scintigraphy for Classification of Amiodarone-induced Thyrotoxicosis"
827:
sensitive to gamma rays to locate the overactive parathyroid before removing it.
385:
287:
267:
911:
3290:
2409:
2295:
1890:
1763:
1720:
1658:
1631:
1567:
1522:
1456:
1279:
O'Connor MK, Li H, Rhodes DJ, Hruska CB, Clancy CB, Vetter RJ (December 2010).
670:
and negative plasma membrane potentials. Sestamibi is mainly used to image the
648:
1171:
1069:
954:
137:
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2922:
2891:
2879:
2874:
2632:
2527:
2107:
2030:
1957:
1117:
883:
771:, a brand name of which is Persantine, a MIBI scan is often referred to as a
723:
cation which, when injected intravenously into a patient, distributes in the
687:
1214:
1004:
987:
3305:
3158:
3153:
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1136:
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1013:
972:
923:
768:
732:
667:
660:
645:
212:
719:
is now a common method of cardiac imaging. Technetium (Tc) sestamibi is a
3228:
2783:
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resulting two sets of images are compared with each other to distinguish
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2014:
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1802:
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811:(less invasive than traditional surgery) to remove the abnormal gland.
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2019:
1963:
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31:
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1937:
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The
Journal of Clinical Endocrinology & Metabolism Case Reports
748:
445:
2437:
839:. Lack of MIBI uptake in the thyroid is compatible with a form of
572:
3243:
2646:
2086:
1969:
1590:
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O'Connor MK, Hruska CB, Weinmann A, Manduca A, Rhodes DJ (2010).
1335:
844:
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794:
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1602:
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1399:
The
Sestamibi Scan for Hyperparathyroidism on: Parathyroid.com
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Medical-surgical
Nursing: Patient-centered Collaborative Care
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1984:
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European
Journal of Nuclear Medicine and Molecular Imaging
814:
674:(heart muscle). It is also used in the work-up of primary
1433:
1340:. In Doty FP, Barber HB, Roehrig H, Schirato RC (eds.).
1244:
Moadel RM (May 2011). "Breast cancer imaging devices".
1055:
666:
Sestamibi is taken up by tissues with large numbers of
1099:
Itzkovich D, Ben-Haim S, Godefroy J, Stokar J (2023).
755:
areas of the myocardium. This imaging technique has a
986:
Gorlin R, Brachfeld N, Macleod C, Bopp P (May 1959).
698:"MIBI scan" redirects here. For the MIBG scan, see
56:. Unsourced material may be challenged and removed.
686:of the parathyroid and in the work-up of possible
651:bound to six (sesta=6) methoxyisobutylisonitrile (
1342:Penetrating Radiation Systems and Applications XI
939:"Myocardial perfusion scintigraphy: the evidence"
843:(type-2 AIT) which may respond to treatment with
3375:
384:
918:. Treasure Island (FL): StatPearls Publishing.
359:
874:cancer, making it not appropriate for general
693:
174:
2453:
1419:
1344:. Vol. 7806. Proc SPIE. pp. 7–21.
1026:
731:) imaging of the heart is performed using a
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340:Hexakis(2-methoxy-2-methylpropylisonitrile)
19:"MIBI" redirects here. For other uses, see
2460:
2446:
1426:
1412:
632:: technetium Tc 99m sestamibi; trade name
495:
404:
136:
1312:
1126:
1116:
1035:. Elsevier Health Sciences. p. 646.
1031:. In Ignatavicius DD, Workman ML (eds.).
1029:"Assessment of the Cardiovascular System"
1003:
962:
424:
116:Learn how and when to remove this message
3296:Orthogonal polarization spectral imaging
763:With dipyridamole (Persantine MIBI scan)
3384:Drugs developed by Bristol Myers Squibb
866:for breast cancer, both more than 85%.
815:Radioguided surgery of the parathyroids
491:
3376:
2428:Therapeutic radiopharmaceuticals (V10)
1243:
778:
2441:
1407:
464:
243:
169:
1160:Breast Cancer Research and Treatment
739:emitted by the technetium-99m as it
636:) is a pharmaceutical agent used in
216:
54:adding citations to reliable sources
25:
2467:
886:exam (300 MBq or 8 mCi).
444:
375:
13:
3103:Sestamibi parathyroid scintigraphy
910:Rizk TH, Nagalli S (5 July 2020).
830:
542:
14:
3435:
1375:
850:
837:amiodarone-induced thyrotoxicosis
659:. The anion is not defined. The
3358:
3357:
1258:10.1053/j.semnuclmed.2010.12.005
530:
524:
30:
2860:Cholangiopancreatography (MRCP)
1329:
1272:
180:TECHNETIUM_TC-99M_SESTAMIBI_KIT
41:needs additional citations for
3108:Radioactive iodine uptake test
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1020:
979:
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912:"Technetium (99mTc) Sestamibi"
903:
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65:"Technetium (99mTc) sestamibi"
1:
3088:Radionuclide ventriculography
2562:Lower gastrointestinal series
2554:Upper gastrointestinal series
896:
3279:Optical coherence tomography
3201:Myocardial perfusion imaging
2789:Dental panoramic radiography
1246:Seminars in Nuclear Medicine
767:When combined with the drug
707:Myocardial perfusion imaging
7:
1058:Annals of Surgical Oncology
864:sensitivity and specificity
791:primary hyperparathyroidism
694:Cardiac imaging (MIBI scan)
10:
3440:
3399:Diagnostic medical imaging
3083:Ventilation/perfusion scan
2558:Small-bowel follow-through
854:
785:Sestamibi parathyroid scan
782:
704:
697:
508:Chemical and physical data
18:
3353:
3332:
3324:Dynamic angiothermography
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3068:
3058:
3049:
2992:Abdominal ultrasonography
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1070:10.1245/s10434-007-9519-0
955:10.1007/s00259-003-1344-5
618:Technetium (Tc) sestamibi
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130:Technetium (Tc) sestamibi
3409:Organometallic compounds
3394:Diagnostic endocrinology
3314:Non-contact thermography
3093:Radionuclide angiography
2945:Doppler echocardiography
1387:Molecular Breast Imaging
1382:Cardiolite official page
1027:Ignatavicius DD (2015).
823:, the surgeon can use a
3098:Radioisotope renography
2154:Gallium (Ga) gozetotide
1698:Iodinated human albumin
1215:10.1148/radiol.10100625
1172:10.1023/A:1024417331304
1005:10.1161/01.CIR.19.5.705
876:breast cancer screening
640:imaging. The drug is a
3133:Gastric emptying study
1449:Central nervous system
1118:10.1210/jcemcr/luac011
2794:X-ray motion analysis
2677:X-ray microtomography
2596:Hysterosalpingography
2503:Pneumoencephalography
2083:Fludeoxyglucose (18F)
2010:Pittsburgh compound B
1651:Cardiovascular system
3424:Technetium compounds
3414:Radiopharmaceuticals
3319:Contact thermography
3029:Emergency ultrasound
2967:Transcranial Doppler
2718:Abdominal and pelvis
2129:Fluorothymidine F-18
2124:Fluoroestradiol F-18
2043:Desmethoxyfallypride
1550:Sodium iodohippurate
1436:radiopharmaceuticals
773:Persantine MIBI scan
642:coordination complex
50:improve this article
3286:Confocal microscopy
3164:Indium-111 WBC scan
2987:Echoencephalography
2723:Virtual colonoscopy
2113:Fluorodeoxysorbitol
1857:Fluoroethyltyrosine
1796:Satumomab pendetide
1297:2010MedPh..37.6187O
891:dense breast tissue
779:Parathyroid imaging
684:radioguided surgery
676:hyperparathyroidism
132:
16:Pharmaceutical drug
3274:Optical tomography
3123:Dacryoscintigraphy
3118:Immunoscintigraphy
2757:Whole body imaging
2508:Dental radiography
2199:Piflufolastat F-18
2068:Flotufolastat F-18
2063:Flortaucipir (18F)
1881:Piflufolastat F-18
1852:Fluorodeoxyglucose
1791:Capromab pendetide
1614:Respiratory system
1504:Flutemetamol (18F)
1392:2012-08-12 at the
644:consisting of the
128:
3404:Methoxy compounds
3371:
3370:
3333:Target conditions
3256:
3255:
3252:
3251:
3172:
3171:
3113:Bone scintigraphy
3078:Scintimammography
3073:Cholescintigraphy
2918:contrast-enhanced
2812:
2811:
2772:
2771:
2762:Full-body CT scan
2662:General operation
2641:
2640:
2611:Angiocardiography
2435:
2434:
2314:
2313:
2208:Rubidium chloride
2174:N-Methylspiperone
2134:Flurpiridaz (18F)
2058:Florbetapir (18F)
2053:Florbetaben (18F)
2005:N-Methylspiperone
1836:Iobenguane (131I)
1823:Iobenguane (123I)
1688:Rubidium chloride
1500:Florbetapir (18F)
1480:Iofetamine (123I)
1350:10.1117/12.864649
1305:10.1118/1.3512759
1291:(12): 6187–6198.
1064:(12): 3401–3402.
857:Scintimammography
809:parathyroidectomy
615:
614:
574:Interactive image
477:CompTox Dashboard
247:
172:
126:
125:
118:
100:
3431:
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2940:Echocardiography
2799:Hounsfield scale
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2571:Cholecystography
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2455:
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2438:
1934:
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1833:
1820:
1807:
1779:Hynic-octreotide
1587:Gastrointestinal
1485:Iolopride (123I)
1475:Ioflupane (123I)
1428:
1421:
1414:
1405:
1404:
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1007:
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638:nuclear medicine
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315:Fecal (33%) and
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3234:PET mammography
3205:
3168:
3154:Gallium-67 scan
3149:Octreotide scan
3137:
3045:
2896:
2808:
2768:
2691:
2672:High-resolution
2637:
2601:Skeletal survey
2567:Cholangiography
2480:
2471:
2469:Medical imaging
2466:
2436:
2431:
2430:
2424:
2320:Isotopes used:
2310:
2219:
1925:
1917:
1912:Iodocholesterol
1885:
1862:Sodium fluoride
1831:
1818:
1805:
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1703:
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1608:
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1532:
1515:Skeletal system
1509:
1443:
1432:
1394:Wayback Machine
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1373:
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1334:
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1285:Medical Physics
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831:Thyroid imaging
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342:technetium (Tc)
341:
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278:Protein binding
268:Bioavailability
260:Pharmacokinetic
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39:This article
37:
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22:
3340:Acute stroke
3306:Thermography
3061:scintigraphy
3051:Radionuclide
3039:pre-hospital
2885:Tractography
2804:Radiodensity
2706:calcium scan
2667:Quantitative
2415:thallium-201
2400:samarium-153
2237:scintigraphy
2144:Flutemetamol
2078:Fluciclovine
1847:Fluciclovine
1810:Minretumomab
1709:Inflammation
1662:
1361:. Retrieved
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788:
772:
769:dipyridamole
766:
745:
733:gamma camera
716:
712:
710:
678:to identify
668:mitochondria
665:
661:generic drug
652:
646:radioisotope
633:
625:
624:) (commonly
617:
616:
605:
298:Elimination
235:Legal status
229:Legal status
161:License data
112:
103:
93:
86:
79:
72:
60:
48:Please help
43:verification
40:
3389:Isocyanides
3229:Cardiac PET
3002:renal tract
2977:Gynecologic
2909:Techniques
2880:restriction
2855:Angiography
2838:Neurography
2784:Fluoroscopy
2730:Angiography
2711:angiography
2655:Techniques:
2616:Aortography
2606:Angiography
2586:Cystography
2576:Mammography
2518:Myelography
2513:Sialography
2482:radiography
2405:selenium-75
2395:rubidium-82
2385:nitrogen-13
2380:krypton-81m
2345:fluorine-18
2330:chromium-51
1980:Carfentanil
1926:(including
1769:Arcitumomab
1735:Tilmanocept
1725:Exametazime
1668:Tetrofosmin
1461:Exametazime
1434:Diagnostic
1363:10 December
992:Circulation
916:StatPearls
841:thyroiditis
799:hyperplasia
757:sensitivity
680:parathyroid
557: g·mol
361:109581-73-9
324:Identifiers
198:Intravenous
151:Trade names
3378:Categories
3142:Full body:
2928:endoscopic
2902:Ultrasound
2831:functional
2628:Lymphogram
2623:Venography
2591:Arthrogram
2426:See also:
2375:iodine-131
2370:iodine-125
2365:iodine-123
2360:indium-111
2355:gallium-68
2350:gallium-67
2214:Setoperone
2139:Fluspidine
2119:Fluorodopa
2102:Altanserin
2093:Flumazenil
2048:Fallypride
2015:Raclopride
2000:Methionine
1995:Flumazenil
1966:(Cimbi-36)
1572:Mertiatide
897:References
737:gamma rays
725:myocardium
721:lipophilic
700:Iobenguane
672:myocardium
634:Cardiolite
562:3D model (
550:Molar mass
466:CHEBI:9423
426:971Z4W1S09
397:ChemSpider
352:CAS Number
333:IUPAC name
288:Metabolism
155:Cardiolite
76:newspapers
3345:Pregnancy
3224:Brain PET
3192:gamma ray
3128:DMSA scan
2982:Obstetric
2875:diffusion
2870:Sequences
2848:perfusion
2740:Pulmonary
2687:Cone beam
2581:Pyelogram
2420:xenon-133
2390:oxygen-15
2340:copper-64
2335:cobalt-57
2325:carbon-11
2225:gamma ray
2073:Flubatine
2020:Verapamil
1964:25B-NBOMe
1958:ME@HAPTHI
1774:Votumumab
1730:Sulesomab
1713:infection
1678:Imciromab
1663:Sestamibi
1490:Iomazenil
1358:121649895
1203:Radiology
1145:254358222
753:infarcted
713:MIBI scan
626:sestamibi
311:Excretion
300:half-life
191:Routes of
106:June 2011
3363:Category
3215:positron
2735:Coronary
2089:analogue
1938:positron
1874:Dotatate
1390:Archived
1323:21302775
1266:21440698
1231:34145938
1223:21045179
1188:10769269
1180:12889605
1137:37908259
1128:10578384
1086:11371876
1078:17899291
1014:13652363
973:15129710
924:31985941
845:steroids
749:ischemic
608:(verify)
305:Variable
205:ATC code
3262:Optical
3244:PET-MRI
3024:Carotid
3019:Scrotal
2913:doppler
2843:Cardiac
2752:Thyroid
2696:Targets
2647:CT scan
2087:glucose
2031:Ammonia
1975:Choline
1970:Acetate
1928:tracers
1591:Hepatic
1314:2997811
1293:Bibcode
964:2562441
872:causing
821:surgery
795:adenoma
657:ligands
514:Formula
372:PubChem
221:)
215: (
213:V09GA01
178::
90:scholar
3239:PET-CT
3014:Breast
3009:Rectal
2933:duplex
2865:Breast
2702:Heart
2229:photon
2179:Nifene
2164:Mefway
2085:(FDG)-
1832:
1819:
1806:
1636:Tc-MAA
1603:SeHCAT
1356:
1321:
1311:
1264:
1229:
1221:
1186:
1178:
1143:
1135:
1125:
1084:
1076:
1039:
1012:
971:
961:
922:
741:decays
588:SMILES
446:D01060
406:396214
250:℞-only
248:
173:
92:
85:
78:
71:
63:
3266:Laser
3188:SPECT
2997:renal
2826:Brain
2777:Other
2477:X-ray
2233:SPECT
2193:Water
2149:FMISO
2115:(FDS)
1756:Tumor
1538:Renal
1354:S2CID
1227:S2CID
1184:S2CID
1141:S2CID
1082:S2CID
825:probe
751:from
729:SPECT
564:JSmol
457:ChEBI
319:(27%)
317:renal
97:JSTOR
83:books
3034:FAST
2747:Head
2169:MPPF
1990:DTBZ
1985:DASB
1945:list
1561:ETS2
1365:2013
1319:PMID
1262:PMID
1219:PMID
1176:PMID
1133:PMID
1074:PMID
1037:ISBN
1010:PMID
969:PMID
920:PMID
802:the
653:MIBI
437:KEGG
417:UNII
386:5384
262:data
69:news
21:Mibi
3211:PET
3179:ECT
3177:3D/
3059:2D/
2960:ICE
2955:TEE
2950:TTE
2818:MRI
2549:DXR
2545:DXA
2540:KUB
2535:AXR
2523:CXR
2184:FET
1942:PET
1440:V09
1346:doi
1309:PMC
1301:doi
1254:doi
1211:doi
1207:258
1168:doi
1123:PMC
1113:doi
1066:doi
1000:doi
959:PMC
951:doi
789:In
743:.
715:or
630:USP
622:INN
555:777
482:EPA
376:CID
292:Nil
218:WHO
176:FDA
52:by
3380::
3217:):
3194:):
2923:3D
2491:2D
2306:Xe
2301:Tl
2296:Tc
2291:Se
2286:Sm
2281:Kr
2261:In
2256:Ga
2251:Co
2246:Cr
2204:Rb
2159:Ga
2038:Cu
1906:/
1869:Cu
1786:In
1764:Tc
1746:Ga
1741:In
1721:Tc
1684:Rb
1674:In
1659:Tc
1638:,
1632:Tc
1627:Kr
1622:Xe
1599:Se
1574:,
1568:Tc
1556:Cu
1523:Tc
1502:,
1463:,
1457:Tc
1352:.
1317:.
1307:.
1299:.
1289:37
1287:.
1283:.
1260:.
1250:41
1248:.
1225:.
1217:.
1205:.
1182:.
1174:.
1164:80
1162:.
1139:.
1131:.
1121:.
1107:.
1103:.
1080:.
1072:.
1062:14
1060:.
1008:.
996:19
994:.
990:.
967:.
957:.
947:31
945:.
941:.
914:.
847:.
775:.
711:A
690:.
655:)
628:;
543:Tc
528:66
522:36
282:1%
272:NA
244:US
170:US
3264:/
3213:(
3190:(
2569:/
2560:/
2556:/
2547:/
2479:/
2461:e
2454:t
2447:v
2276:I
2271:I
2266:I
2239:)
2235:/
2231:(
2227:/
2216:)
2210:)
2206:(
2195:)
2191:(
2189:O
2104:)
2100:(
2098:F
2026:N
2022:)
1960:)
1956:(
1954:C
1947:)
1940:(
1930:)
1914:)
1910:(
1908:I
1904:I
1899:I
1842:F
1838:)
1834:(
1829:I
1825:)
1821:(
1816:I
1812:)
1808:(
1803:I
1737:)
1723:(
1711:/
1700:)
1696:(
1694:I
1690:)
1686:(
1680:)
1676:(
1670:)
1661:(
1642:)
1634:(
1605:)
1601:(
1589:/
1578:)
1570:(
1552:)
1548:(
1546:I
1529:)
1525:(
1506:)
1498:(
1496:F
1492:)
1473:(
1471:I
1467:)
1459:(
1442:)
1438:(
1427:e
1420:t
1413:v
1367:.
1348::
1325:.
1303::
1295::
1268:.
1256::
1233:.
1213::
1190:.
1170::
1147:.
1115::
1109:1
1088:.
1068::
1045:.
1016:.
1002::
975:.
953::
926:.
702:.
620:(
566:)
540:6
537:O
534:6
531:N
525:H
519:C
484:)
480:(
246::
119:)
113:(
108:)
104:(
94:·
87:·
80:·
73:·
46:.
23:.
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